Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
CLSTN1	22883	broad.mit.edu	37	1	9833182	9833182	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9833182delA	uc001aqh.2	-						CLSTN1_uc001aqi.2_Intron|CLSTN1_uc010oag.1_Intron	NM_001009566	NP_001009566			calsyntenin 1 isoform 1						homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10412667	10412667	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10412667delT	uc001aqx.3	+						KIF1B_uc001aqw.3_Intron|KIF1B_uc001aqy.2_Intron|KIF1B_uc001aqz.2_Intron|KIF1B_uc001ara.2_Intron|KIF1B_uc001arb.2_Intron	NM_015074	NP_055889			kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	13197573	13197573	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13197573delT								LOC440563 (13606 upstream) : PRAMEF3 (131260 downstream)																																			---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19439932	19439932	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19439932delA	uc001bbi.2	-						UBR4_uc001bbj.1_3'UTR	NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)												OREG0013168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KIAA0090	23065	broad.mit.edu	37	1	19557064	19557065	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19557064_19557065delAA	uc001bbo.2	-						KIAA0090_uc001bbp.2_Intron|KIAA0090_uc001bbq.2_Intron|KIAA0090_uc001bbr.2_Intron	NM_015047	NP_055862			hypothetical protein LOC23065 precursor							integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)														---	---	---	---
ZBTB40	9923	broad.mit.edu	37	1	22832398	22832398	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22832398delA	uc001bft.2	+						ZBTB40_uc001bfu.2_Intron|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_Intron	NM_001083621	NP_001077090			zinc finger and BTB domain containing 40						bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)														---	---	---	---
SH3BGRL3	83442	broad.mit.edu	37	1	26607440	26607440	+	Intron	DEL	G	-	-	rs140695506	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26607440delG	uc001blu.2	+							NM_031286	NP_112576			SH3 domain binding glutamic acid-rich protein						cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity				0		all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
DNAJC8	22826	broad.mit.edu	37	1	28536713	28536713	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28536713delA	uc001bpn.2	-						DNAJC8_uc001bpo.2_Intron	NM_014280	NP_055095			DnaJ (Hsp40) homolog, subfamily C, member 8						nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
EPB41	2035	broad.mit.edu	37	1	29435711	29435713	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29435711_29435713delAAA	uc001brm.1	+						EPB41_uc001brg.1_Intron|EPB41_uc001brh.1_Intron|EPB41_uc001bri.1_Intron|EPB41_uc001brj.1_Intron|EPB41_uc001brl.1_Intron|EPB41_uc009vtl.1_Intron|EPB41_uc009vtm.1_Intron|EPB41_uc009vtn.1_Intron	NM_203342	NP_976217			erythrocyte membrane protein band 4.1						blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	31580928	31580928	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:31580928delT								PUM1 (42165 upstream) : NKAIN1 (71665 downstream)																																			---	---	---	---
ZCCHC17	51538	broad.mit.edu	37	1	31791791	31791792	+	Intron	INS	-	A	A	rs56053258		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:31791791_31791792insA	uc001bsp.1	+						ZCCHC17_uc001bsq.1_Intron|ZCCHC17_uc010ogf.1_Intron|ZCCHC17_uc009vtu.1_Intron|ZCCHC17_uc001bsr.1_Intron|ZCCHC17_uc009vtv.1_Intron	NM_016505	NP_057589			zinc finger, CCHC domain containing 17							nucleolus	RNA binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)														---	---	---	---
COL16A1	1307	broad.mit.edu	37	1	32131296	32131296	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32131296delG	uc001btk.1	-						COL16A1_uc001bti.1_Intron|COL16A1_uc001btj.1_Intron	NM_001856	NP_001847			alpha 1 type XVI collagen precursor						cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)														---	---	---	---
ZBTB8A	653121	broad.mit.edu	37	1	33060538	33060538	+	Intron	DEL	T	-	-	rs75976891		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33060538delT	uc001bvn.2	+						ZBTB8A_uc001bvk.2_Intron|ZBTB8A_uc001bvm.2_Intron	NM_001040441	NP_001035531			zinc finger and BTB domain containing 8A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
RBBP4	5928	broad.mit.edu	37	1	33133737	33133737	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33133737delA	uc001bvr.2	+						RBBP4_uc001bvs.2_Intron|RBBP4_uc010ohj.1_Intron|RBBP4_uc010ohk.1_Intron	NM_005610	NP_005601			retinoblastoma binding protein 4 isoform a						cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34008507	34008507	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34008507delA	uc001bxn.1	-						CSMD2_uc001bxm.1_Intron	NM_052896	NP_443128			CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39796845	39796861	+	5'UTR	DEL	TTTTTTTTTTTTTTTTT	-	-	rs71810789		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39796845_39796861delTTTTTTTTTTTTTTTTT	uc010oiu.1	+	1					MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033			microfilament and actin filament cross-linker						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
TRIT1	54802	broad.mit.edu	37	1	40307167	40307167	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40307167delA	uc010oiz.1	-	11					TRIT1_uc001cec.3_RNA|TRIT1_uc001ced.3_3'UTR|TRIT1_uc001cee.3_RNA|TRIT1_uc001cef.3_RNA|TRIT1_uc001ceg.3_3'UTR|TRIT1_uc001ceh.3_3'UTR|TRIT1_uc009vvv.2_3'UTR|TRIT1_uc001cei.3_3'UTR|TRIT1_uc001ceq.2_3'UTR|TRIT1_uc001cek.2_3'UTR|TRIT1_uc009vvx.2_RNA|TRIT1_uc001cel.2_RNA|TRIT1_uc001cem.2_3'UTR|TRIT1_uc001cen.2_3'UTR|TRIT1_uc001ceo.2_3'UTR|TRIT1_uc001cep.2_3'UTR	NM_017646	NP_060116			tRNA isopentenyltransferase 1 precursor						tRNA processing	mitochondrion	ATP binding|metal ion binding|tRNA dimethylallyltransferase activity			ovary(1)	1	all_cancers(7;4.55e-14)|all_lung(5;1.23e-16)|all_epithelial(6;2.17e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;3.29e-18)|Epithelial(16;3.07e-17)|all cancers(16;6.21e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
CCDC30	728621	broad.mit.edu	37	1	43010889	43010889	+	Intron	DEL	A	-	-	rs141597374		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43010889delA	uc009vwk.1	+						CCDC30_uc001chm.2_Intron|CCDC30_uc001chn.2_Intron|CCDC30_uc010oju.1_Intron|CCDC30_uc001chp.2_Intron	NM_001080850	NP_001074319			coiled-coil domain containing 30												0																		---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44421863	44421863	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44421863delT	uc001ckx.2	+							NM_014652	NP_055467			importin 13						protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
Unknown	0	broad.mit.edu	37	1	50865017	50865017	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50865017delT								ELAVL4 (197477 upstream) : DMRTA2 (18212 downstream)																																			---	---	---	---
EPS15	2060	broad.mit.edu	37	1	51864868	51864868	+	Intron	DEL	A	-	-	rs76569238		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51864868delA	uc001csq.1	-						EPS15_uc009vyz.1_Intron|EPS15_uc001csp.3_Intron	NM_001981	NP_001972			epidermal growth factor receptor pathway						cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2								T	MLL	ALL								---	---	---	---
C1orf83	127428	broad.mit.edu	37	1	54555444	54555444	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54555444delT	uc001cwt.1	+						C1orf83_uc001cwu.1_Intron	NM_153035	NP_694580			hypothetical protein LOC127428						transcription, DNA-dependent	nucleus	DNA binding				0																		---	---	---	---
PRKAA2	5563	broad.mit.edu	37	1	57158313	57158313	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57158313delT	uc001cyk.3	+							NM_006252	NP_006243			AMP-activated protein kinase alpha 2 catalytic						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6																		---	---	---	---
C1orf168	199920	broad.mit.edu	37	1	57233359	57233359	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57233359delA	uc001cym.3	-						C1orf168_uc009vzu.1_Intron	NM_001004303	NP_001004303			hypothetical protein LOC199920											ovary(3)|skin(2)	5																		---	---	---	---
HOOK1	51361	broad.mit.edu	37	1	60294431	60294431	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:60294431delT	uc009wad.2	+						HOOK1_uc001czo.2_Intron|HOOK1_uc001czp.2_Intron|HOOK1_uc010oor.1_Intron	NM_015888	NP_056972			hook homolog 1						early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)																	---	---	---	---
EFCAB7	84455	broad.mit.edu	37	1	64017263	64017263	+	Intron	DEL	A	-	-	rs141911490		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:64017263delA	uc001dbf.2	+							NM_032437	NP_115813			EF-hand calcium binding domain 7								calcium ion binding				0																		---	---	---	---
JAK1	3716	broad.mit.edu	37	1	65310329	65310329	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65310329delA	uc001dbu.1	-						JAK1_uc009wam.1_Intron|JAK1_uc009wal.1_Intron	NM_002227	NP_002218			janus kinase 1						interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)				Mis		ALL								---	---	---	---
LEPR	3953	broad.mit.edu	37	1	65915368	65915369	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65915368_65915369delTT	uc001dci.2	+						LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc009waq.2_Intron	NM_002303	NP_002294			leptin receptor isoform 1						energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
WDR78	79819	broad.mit.edu	37	1	67303295	67303295	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67303295delT	uc001dcx.2	-						WDR78_uc001dcy.2_3'UTR|WDR78_uc009waw.2_Intron|WDR78_uc009wax.2_Intron	NM_024763	NP_079039			WD repeat domain 78 isoform 1											ovary(2)	2																		---	---	---	---
ANKRD13C	81573	broad.mit.edu	37	1	70758274	70758274	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:70758274delA	uc001dex.3	-						ANKRD13C_uc009wbk.2_Intron	NM_030816	NP_110443			ankyrin repeat domain 13C						protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding				0																		---	---	---	---
CTH	1491	broad.mit.edu	37	1	70895655	70895655	+	Intron	DEL	A	-	-	rs144207053		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:70895655delA	uc001dfd.2	+						CTH_uc009wbl.1_Intron|CTH_uc001dfe.2_Intron|CTH_uc010oqq.1_Intron	NM_001902	NP_001893			cystathionase isoform 1						cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			lung(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)													---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74667251	74667251	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74667251delT	uc001dge.1	+						TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc001dgb.1_Intron|FPGT_uc010oqv.1_Intron	NM_001112808	NP_001106279			TNNI3 interacting kinase isoform a							cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	78240627	78240628	+	IGR	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78240627_78240628delTT								USP33 (15090 upstream) : FAM73A (4681 downstream)																																			---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82302485	82302486	+	Intron	DEL	GA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82302485_82302486delGA	uc001dit.3	+						LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Intron|LPHN2_uc001div.2_Intron|LPHN2_uc009wcd.2_Intron	NM_012302	NP_036434			latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
SSX2IP	117178	broad.mit.edu	37	1	85129883	85129884	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85129883_85129884insA	uc001dkh.2	-						SSX2IP_uc001dkf.2_Intron|SSX2IP_uc001dkg.2_Intron|SSX2IP_uc010orz.1_Intron|SSX2IP_uc001dki.2_Intron|SSX2IP_uc010osa.1_Intron|SSX2IP_uc001dkj.2_Intron|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Intron	NM_014021	NP_054740			synovial sarcoma, X breakpoint 2 interacting						cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
GBP2	2634	broad.mit.edu	37	1	89574123	89574123	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89574123delT	uc001dmz.1	-						GBP2_uc001dmy.1_Intron	NM_004120	NP_004111			guanylate binding protein 2,						interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)														---	---	---	---
CCDC18	343099	broad.mit.edu	37	1	93712624	93712625	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93712624_93712625insT	uc001dpq.2	+							NM_206886	NP_996769			sarcoma antigen NY-SAR-41											ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)														---	---	---	---
FNBP1L	54874	broad.mit.edu	37	1	94018104	94018104	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94018104delT	uc001dpw.2	+	14					FNBP1L_uc001dpv.2_3'UTR|FNBP1L_uc010otk.1_3'UTR|FNBP1L_uc010otl.1_3'UTR	NM_001024948	NP_001020119			formin binding protein 1-like isoform 1						endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)														---	---	---	---
GCLM	2730	broad.mit.edu	37	1	94359971	94359971	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94359971delT	uc001dqg.1	-							NM_002061	NP_002052			glutamate-cysteine ligase regulatory protein						glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)													---	---	---	---
ARHGAP29	9411	broad.mit.edu	37	1	94669701	94669704	+	Intron	DEL	TTTT	-	-	rs77020055		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94669701_94669704delTTTT	uc001dqj.3	-						ARHGAP29_uc009wdq.1_Intron|ARHGAP29_uc001dql.2_Intron	NM_004815	NP_004806			PTPL1-associated RhoGAP 1						Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)														---	---	---	---
DPYD	1806	broad.mit.edu	37	1	97547716	97547716	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:97547716delA	uc001drv.2	-							NM_000110	NP_000101			dihydropyrimidine dehydrogenase isoform 1						'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)													---	---	---	---
FRRS1	391059	broad.mit.edu	37	1	100207577	100207577	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100207577delT	uc001dsh.1	-							NM_001013660	NP_001013682			stromal cell derived factor receptor 2 homolog						electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	101694207	101694207	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101694207delT								DPH5 (202563 upstream) : S1PR1 (8098 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	104470505	104470505	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:104470505delT								AMY1A (263333 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	106434900	106434900	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:106434900delA								None (None upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	120144237	120144237	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120144237delA								HSD3B1 (86556 upstream) : ZNF697 (17763 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	121245721	121245721	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:121245721delA								FCGR1B (309777 upstream) : LOC647121 (15189 downstream)																																			---	---	---	---
LOC200030	200030	broad.mit.edu	37	1	148349431	148349432	+	5'Flank	INS	-	G	G	rs67020224		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:148349431_148349432insG	uc001eqf.2	-						LOC200030_uc001eqe.2_5'Flank|LOC200030_uc001eqg.2_5'Flank|NBPF14_uc009wkf.1_5'Flank|uc001erd.3_5'Flank|uc001erc.3_5'Flank|uc010paj.1_5'Flank|uc010pav.1_5'Flank|uc010paw.1_5'Flank	NM_017940	NP_060410			hypothetical protein LOC55672							cytoplasm					0																		---	---	---	---
SF3B4	10262	broad.mit.edu	37	1	149899306	149899306	+	Intron	DEL	A	-	-	rs75973795		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149899306delA	uc001etj.1	-						SF3B4_uc001eti.1_5'Flank|SF3B4_uc001etk.1_Intron|SF3B4_uc009wll.1_Intron	NM_005850	NP_005841			splicing factor 3b, subunit 4							nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)															---	---	---	---
POGZ	23126	broad.mit.edu	37	1	151384306	151384306	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151384306delA	uc001eyd.1	-						POGZ_uc001eye.1_Intron|POGZ_uc010pdb.1_Intron|POGZ_uc001eyf.1_Intron|POGZ_uc010pdc.1_Intron|POGZ_uc009wmv.1_Intron|POGZ_uc010pdd.1_Intron	NM_015100	NP_055915			pogo transposable element with ZNF domain						cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
UBAP2L	9898	broad.mit.edu	37	1	154213901	154213901	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154213901delA	uc001fep.3	+						UBAP2L_uc009wot.2_Intron|UBAP2L_uc010pek.1_Intron|UBAP2L_uc010pel.1_Intron|UBAP2L_uc010pen.1_Intron	NM_014847	NP_055662			ubiquitin associated protein 2-like isoform a						binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	154350594	154350594	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154350594delT								ATP8B2 (26815 upstream) : IL6R (27075 downstream)																																			---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155347853	155347853	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155347853delA	uc009wqq.2	-						RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Intron	NM_018489	NP_060959			absent, small, or homeotic 1-like						cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
MEX3A	92312	broad.mit.edu	37	1	156046593	156046594	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156046593_156046594insG	uc001fnd.3	-	2	1334_1335	c.1334_1335insC	c.(1333-1335)CCGfs	p.P445fs		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	445						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)																	---	---	---	---
IFI16	3428	broad.mit.edu	37	1	158990473	158990473	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158990473delT	uc001ftg.2	+						IFI16_uc010pis.1_Intron	NM_005531	NP_005522			interferon, gamma-inducible protein 16						cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)																	---	---	---	---
LY9	4063	broad.mit.edu	37	1	160788309	160788309	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160788309delA	uc001fwu.2	+						LY9_uc001fwv.2_Intron|LY9_uc001fww.2_Intron|LY9_uc001fwx.2_Intron|LY9_uc001fwy.1_Intron|LY9_uc001fwz.2_Intron	NM_002348	NP_002339			lymphocyte antigen 9 isoform a						cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)															---	---	---	---
UHMK1	127933	broad.mit.edu	37	1	162470205	162470205	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162470205delA	uc001gcc.1	+						UHMK1_uc001gcb.1_Intron|UHMK1_uc009wuu.1_Intron	NM_175866	NP_787062			kinase interacting stathmin						cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)															---	---	---	---
RGS4	5999	broad.mit.edu	37	1	163038839	163038839	+	5'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163038839delT	uc009wuy.2	+	1					RGS4_uc001gcl.3_Intron|RGS4_uc009wuz.2_5'Flank|RGS4_uc009wva.2_5'Flank	NM_005613	NP_005604			regulator of G-protein signaling 4 isoform 2						inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3																OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SELE	6401	broad.mit.edu	37	1	169694717	169694717	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169694717delA	uc001ggm.3	-						C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441			selectin E precursor						actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)																	---	---	---	---
KIFAP3	22920	broad.mit.edu	37	1	169923260	169923260	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169923260delA	uc001ggv.2	-						KIFAP3_uc010plx.1_Intron	NM_014970	NP_055785			kinesin-associated protein 3						blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
C1orf9	51430	broad.mit.edu	37	1	172524885	172524885	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172524885delT	uc001giq.3	+						C1orf9_uc010pmm.1_Intron|C1orf9_uc009wwd.2_Intron|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098			chromosome 1 open reading frame 9 protein						multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)														---	---	---	---
C1orf9	51430	broad.mit.edu	37	1	172547135	172547135	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172547135delA	uc001giq.3	+						C1orf9_uc010pmm.1_Intron|C1orf9_uc009wwd.2_Intron|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098			chromosome 1 open reading frame 9 protein						multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)														---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174721308	174721308	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174721308delA	uc001gjx.2	+						RABGAP1L_uc001gkb.3_Intron|RABGAP1L_uc001gkc.3_Intron|RABGAP1L_uc001gkd.3_Intron	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176740375	176740375	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176740375delT	uc001gkz.2	+						PAPPA2_uc009www.2_Intron	NM_020318	NP_064714			pappalysin 2 isoform 1						cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
XPR1	9213	broad.mit.edu	37	1	180805492	180805493	+	Intron	INS	-	AA	AA	rs112629887		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180805492_180805493insAA	uc001goi.2	+						XPR1_uc009wxm.2_Intron|XPR1_uc009wxn.2_Intron	NM_004736	NP_004727			xenotropic and polytropic retrovirus receptor							integral to plasma membrane	G-protein coupled receptor activity				0																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181690718	181690718	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181690718delA	uc001gow.2	+						CACNA1E_uc009wxs.2_Intron	NM_000721	NP_000712			calcium channel, voltage-dependent, R type,						energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
RGL1	23179	broad.mit.edu	37	1	183861053	183861053	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183861053delA	uc001gqo.2	+						RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron|RGL1_uc010poi.1_Intron	NM_015149	NP_055964			ral guanine nucleotide dissociation						cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186040037	186040037	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186040037delA	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186321336	186321336	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186321336delT	uc001grv.2	-							NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
KCNT2	343450	broad.mit.edu	37	1	196309709	196309709	+	Intron	DEL	A	-	-	rs71639782		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196309709delA	uc001gtd.1	-						KCNT2_uc009wyt.1_Intron|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Intron|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Intron|KCNT2_uc001gth.1_Intron	NM_198503	NP_940905			potassium channel, subfamily T, member 2							voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7																		---	---	---	---
DENND1B	163486	broad.mit.edu	37	1	197480840	197480840	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197480840delA	uc010ppe.1	-						DENND1B_uc010ppf.1_Intron	NM_001142795	NP_001136267			DENN/MADD domain containing 1B isoform 1							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
CAMSAP1L1	23271	broad.mit.edu	37	1	200816521	200816521	+	Intron	DEL	G	-	-	rs2172666		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200816521delG	uc001gvl.2	+						CAMSAP1L1_uc001gvk.2_Intron|CAMSAP1L1_uc001gvm.2_Intron	NM_203459	NP_982284			calmodulin regulated spectrin-associated protein							cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
PPP1R12B	4660	broad.mit.edu	37	1	202407353	202407353	+	Intron	DEL	A	-	-	rs78305367	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202407353delA	uc001gya.1	+						PPP1R12B_uc001gxy.2_3'UTR|PPP1R12B_uc009xad.1_3'UTR|PPP1R12B_uc009xae.1_3'UTR|PPP1R12B_uc001gxz.1_Intron	NM_002481	NP_002472			protein phosphatase 1, regulatory (inhibitor)						regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
LGTN	1939	broad.mit.edu	37	1	206776680	206776680	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206776680delG	uc001heh.2	-						LGTN_uc009xbw.2_Intron	NM_006893	NP_008824			ligatin						intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	209346640	209346641	+	IGR	INS	-	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209346640_209346641insC								PLXNA2 (928975 upstream) : LOC642587 (255527 downstream)																																			---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213290956	213290956	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213290956delT	uc010ptr.1	+						RPS6KC1_uc001hkd.2_Intron|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Intron|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Intron	NM_012424	NP_036556			ribosomal protein S6 kinase, 52kDa, polypeptide						cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
KCTD3	51133	broad.mit.edu	37	1	215749394	215749394	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215749394delT	uc001hks.2	+						KCTD3_uc001hkt.2_Intron|KCTD3_uc010pub.1_Intron|KCTD3_uc009xdn.2_5'Flank	NM_016121	NP_057205			potassium channel tetramerisation domain							voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	219783680	219783680	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:219783680delT								LYPLAL1 (397474 upstream) : SLC30A10 (75089 downstream)																																			---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228565452	228565452	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228565452delG	uc009xez.1	+						OBSCN_uc001hsr.1_Intron	NM_001098623	NP_001092093			obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
EGLN1	54583	broad.mit.edu	37	1	231502242	231502245	+	Intron	DEL	AAAT	-	-	rs111836138	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231502242_231502245delAAAT	uc001huv.2	-						EGLN1_uc001huu.3_Intron	NM_022051	NP_071334			egl nine homolog 1						negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding				0		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)													---	---	---	---
DISC1	27185	broad.mit.edu	37	1	231837573	231837573	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231837573delT	uc001huz.2	+						TSNAX-DISC1_uc010pwe.1_Intron|TSNAX-DISC1_uc010pwf.1_Intron|TSNAX-DISC1_uc010pwg.1_Intron|TSNAX-DISC1_uc010pwh.1_Intron|TSNAX-DISC1_uc010pwi.1_Intron|TSNAX-DISC1_uc010pwj.1_Intron|TSNAX-DISC1_uc010pwk.1_Intron|TSNAX-DISC1_uc010pwl.1_Intron|DISC1_uc010pwo.1_Intron|DISC1_uc010pwp.1_Intron|DISC1_uc010pwq.1_Intron|DISC1_uc010pwr.1_Intron|DISC1_uc010pws.1_Intron|DISC1_uc010pwt.1_Intron|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_Intron|DISC1_uc010pww.1_Intron|DISC1_uc010pwx.1_Intron|DISC1_uc010pwy.1_Intron|DISC1_uc010pwz.1_Intron|DISC1_uc010pxa.1_Intron|DISC1_uc001huy.2_Intron|DISC1_uc010pxb.1_Intron|DISC1_uc010pxc.1_Intron|DISC1_uc010pxd.1_Intron|DISC1_uc010pxe.1_Intron|DISC1_uc009xfr.2_Intron|DISC1_uc010pxf.1_Intron|DISC1_uc010pxg.1_Intron|DISC1_uc010pxh.1_Intron|DISC1_uc010pxi.1_Intron|DISC1_uc010pxj.1_Intron|DISC1_uc010pxk.1_Intron|DISC1_uc010pxl.1_Intron|DISC1_uc010pxm.1_Intron|DISC1_uc010pxn.1_Intron|DISC1_uc001hva.2_Intron|DISC1_uc010pwm.1_Intron|DISC1_uc001hux.1_Intron|DISC1_uc001hvc.3_Intron|DISC1_uc010pwn.1_Intron	NM_018662	NP_061132			disrupted in schizophrenia 1 isoform L						microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)																---	---	---	---
LYST	1130	broad.mit.edu	37	1	235860710	235860710	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235860710delT	uc001hxj.2	-						LYST_uc001hxi.2_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
ERO1LB	56605	broad.mit.edu	37	1	236399233	236399234	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236399233_236399234delTT	uc001hxt.2	-							NM_019891	NP_063944			endoplasmic reticulum oxidoreductin 1-Lbeta						electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)															---	---	---	---
GREM2	64388	broad.mit.edu	37	1	240656842	240656842	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240656842delT	uc001hys.2	-							NM_022469	NP_071914			gremlin 2 precursor						BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)															---	---	---	---
PLD5	200150	broad.mit.edu	37	1	242383097	242383097	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242383097delT	uc001hzn.1	-						PLD5_uc001hzl.3_Intron|PLD5_uc001hzm.3_Intron|PLD5_uc001hzo.1_Intron					RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;							integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)															---	---	---	---
C1orf150	148823	broad.mit.edu	37	1	247729041	247729042	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247729041_247729042insT	uc001idf.2	+						C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron	NM_145278	NP_660321			hypothetical protein LOC148823												0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)															---	---	---	---
CPSF3	51692	broad.mit.edu	37	2	9611343	9611344	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9611343_9611344delAA	uc002qzo.1	+						CPSF3_uc002qzp.1_Intron|CPSF3_uc002qzq.1_Intron	NM_016207	NP_057291			cleavage and polyadenylation specific factor 3,						histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)														---	---	---	---
DNAJC27	51277	broad.mit.edu	37	2	25180475	25180475	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25180475delA	uc002rft.1	-						DNAJC27_uc010ykn.1_Intron|DNAJC27_uc002rfu.1_Intron|DNAJC27_uc010eyg.1_Intron	NM_016544	NP_057628			DnaJ (Hsp40) homolog, subfamily C, member 27						protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			skin(1)	1																		---	---	---	---
DTNB	1838	broad.mit.edu	37	2	25705872	25705872	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25705872delG	uc002rgh.2	-						DTNB_uc002rgg.2_5'Flank|DTNB_uc010yko.1_Intron|DTNB_uc010ykp.1_Intron|DTNB_uc002rgo.2_Intron|DTNB_uc002rgi.2_Intron|DTNB_uc002rgj.2_Intron|DTNB_uc002rgk.2_Intron|DTNB_uc002rgl.2_Intron|DTNB_uc002rgq.2_Intron|DTNB_uc002rgm.2_Intron|DTNB_uc002rgn.2_Intron|DTNB_uc002rgr.1_Intron|DTNB_uc010ykq.1_Intron	NM_021907	NP_068707			dystrobrevin, beta isoform 1							cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
SLC30A3	7781	broad.mit.edu	37	2	27479122	27479123	+	Intron	DEL	GA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27479122_27479123delGA	uc002rjk.2	-						SLC30A3_uc002rjj.2_Intron|SLC30A3_uc010ylh.1_Intron	NM_003459	NP_003450			solute carrier family 30 (zinc transporter),						regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
RBKS	64080	broad.mit.edu	37	2	28065746	28065746	+	Intron	DEL	T	-	-	rs78190424		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28065746delT	uc002rlo.1	-						RBKS_uc010ezi.1_Intron|RBKS_uc010ymg.1_Intron	NM_022128	NP_071411			ribokinase						D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
XDH	7498	broad.mit.edu	37	2	31600308	31600308	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31600308delA	uc002rnv.1	-							NM_000379	NP_000370			xanthine dehydrogenase						purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)													---	---	---	---
SPAST	6683	broad.mit.edu	37	2	32312744	32312745	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32312744_32312745insT	uc002roc.2	+						SPAST_uc002rod.2_Intron	NM_014946	NP_055761			spastin isoform 1						cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)																	---	---	---	---
HNRPLL	92906	broad.mit.edu	37	2	38813168	38813169	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38813168_38813169delTT	uc002rqw.2	-						HNRPLL_uc002rqx.2_Intron	NM_138394	NP_612403			heterogeneous nuclear ribonucleoprotein L-like						mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)																---	---	---	---
SFRS7	6432	broad.mit.edu	37	2	38973132	38973132	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38973132delA	uc002rqz.2	-						SFRS7_uc002rra.2_Intron|SFRS7_uc010ynp.1_Intron	NM_001031684	NP_001026854			splicing factor, arginine/serine-rich 7						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding				0		all_hematologic(82;0.248)																---	---	---	---
MAP4K3	8491	broad.mit.edu	37	2	39507284	39507284	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39507284delA	uc002rro.2	-						MAP4K3_uc002rrp.2_Intron|MAP4K3_uc010yns.1_Intron	NM_003618	NP_003609			mitogen-activated protein kinase kinase kinase						JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)																---	---	---	---
THADA	63892	broad.mit.edu	37	2	43712611	43712611	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43712611delA	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron|THADA_uc010fas.1_Intron|THADA_uc002rsz.2_Intron|THADA_uc010fat.1_Intron|THADA_uc002rta.2_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
Unknown	0	broad.mit.edu	37	2	44293375	44293377	+	IGR	DEL	TTG	-	-	rs61062797		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44293375_44293377delTTG								LRPPRC (70231 upstream) : PPM1B (102623 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	46483983	46483983	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:46483983delA								PRKCE (68855 upstream) : EPAS1 (40580 downstream)																																			---	---	---	---
EPCAM	4072	broad.mit.edu	37	2	47600582	47600582	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47600582delT	uc002rvx.2	+						EPCAM_uc002rvw.2_Intron	NM_002354	NP_002345			epithelial cell adhesion molecule precursor						positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1														Lynch_syndrome				---	---	---	---
PUS10	150962	broad.mit.edu	37	2	61171973	61171973	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61171973delA	uc010fci.2	-						PUS10_uc002sao.2_Intron|PUS10_uc010ypk.1_Intron	NM_144709	NP_653310			pseudouridylate synthase 10						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)															---	---	---	---
PUS10	150962	broad.mit.edu	37	2	61174964	61174969	+	Intron	DEL	AAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61174964_61174969delAAAAAA	uc010fci.2	-						PUS10_uc002sao.2_Intron|PUS10_uc010ypk.1_Intron	NM_144709	NP_653310			pseudouridylate synthase 10						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)															---	---	---	---
PUS10	150962	broad.mit.edu	37	2	61192800	61192801	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61192800_61192801delTT	uc010fci.2	-						PUS10_uc002sao.2_Intron|PUS10_uc010ypk.1_Intron	NM_144709	NP_653310			pseudouridylate synthase 10						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			ovary(2)|large_intestine(1)|kidney(1)	4			LUSC - Lung squamous cell carcinoma(5;1.56e-06)|Lung(5;2.48e-05)|Epithelial(17;0.113)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	64574952	64574953	+	IGR	INS	-	TG	TG			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64574952_64574953insTG								PELI1 (203347 upstream) : HSPC159 (106374 downstream)																																			---	---	---	---
FBXO41	150726	broad.mit.edu	37	2	73492339	73492339	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73492339delG	uc002sjb.1	-							NM_001080410	NP_001073879			F-box protein 41							intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73826304	73826304	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73826304delT	uc002sje.1	+						ALMS1_uc002sjf.1_Intron|ALMS1_uc002sjh.1_Intron	NM_015120	NP_055935			Alstrom syndrome 1						G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	78020201	78020214	+	IGR	DEL	AAAAAAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:78020201_78020214delAAAAAAAAAAAAAA								LRRTM4 (270699 upstream) : SNAR-H (161819 downstream)																																			---	---	---	---
SUCLG1	8802	broad.mit.edu	37	2	84676708	84676708	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84676708delA	uc002son.2	-						SUCLG1_uc010ysk.1_Intron	NM_003849	NP_003840			succinate-CoA ligase, GDP-forming alpha subunit						tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)													---	---	---	---
C2orf89	129293	broad.mit.edu	37	2	85097203	85097203	+	Intron	DEL	T	-	-	rs35902901		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85097203delT	uc010ysl.1	-						C2orf89_uc002sou.3_Intron|C2orf89_uc010fgc.1_Intron	NM_001080824	NP_001074293			hypothetical protein LOC129293 precursor							integral to membrane				ovary(1)	1																		---	---	---	---
GGCX	2677	broad.mit.edu	37	2	85787730	85787732	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85787730_85787732delAAA	uc002sps.2	-						GGCX_uc010yss.1_5'Flank|GGCX_uc010yst.1_Intron	NM_000821	NP_000812			gamma-glutamyl carboxylase isoform 1						blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			ovary(1)	1					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)													---	---	---	---
RMND5A	64795	broad.mit.edu	37	2	87115220	87115220	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87115220delT	uc002srs.3	+						uc010fgu.1_Intron					SubName: Full=cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1;											ovary(1)|skin(1)	2																		---	---	---	---
RMND5A	64795	broad.mit.edu	37	2	87120570	87120570	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87120570delT	uc002srs.3	+						uc010fgu.1_Intron					SubName: Full=cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1;											ovary(1)|skin(1)	2																		---	---	---	---
C2orf55	343990	broad.mit.edu	37	2	99454495	99454495	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99454495delG	uc002szf.1	-							NM_207362	NP_997245			hypothetical protein LOC343990												0																		---	---	---	---
AFF3	3899	broad.mit.edu	37	2	100627741	100627741	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100627741delA	uc002tag.2	-						AFF3_uc002taf.2_Intron|AFF3_uc010fiq.1_Intron|AFF3_uc010yvr.1_Intron|AFF3_uc002tah.1_Intron|AFF3_uc010fir.1_Intron	NM_002285	NP_002276			AF4/FMR2 family, member 3 isoform 1						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6																		---	---	---	---
NMS	129521	broad.mit.edu	37	2	101089440	101089440	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:101089440delT	uc002tan.1	+							NM_001011717	NP_001011717			neuromedin S precursor						neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1																		---	---	---	---
NPHP1	4867	broad.mit.edu	37	2	110886672	110886672	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:110886672delA	uc002tfn.3	-						NPHP1_uc002tfm.3_Intron|NPHP1_uc002tfl.3_Intron|NPHP1_uc002tfo.3_Intron|NPHP1_uc010ywx.1_Intron|NPHP1_uc010fjv.1_Intron	NM_207181	NP_997064			nephrocystin 1 isoform 2						actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			ovary(2)	2																		---	---	---	---
POLR1B	84172	broad.mit.edu	37	2	113333512	113333513	+	3'UTR	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113333512_113333513insA	uc002thw.2	+	15					POLR1B_uc010fkn.2_3'UTR|POLR1B_uc002thx.2_3'UTR|POLR1B_uc010fko.2_3'UTR|POLR1B_uc010fkp.2_3'UTR|POLR1B_uc010yxn.1_3'UTR|POLR1B_uc002thy.2_3'UTR|POLR1B_uc010yxo.1_3'UTR	NM_019014	NP_061887			RNA polymerase I polypeptide B isoform 1						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116497666	116497667	+	Intron	DEL	GT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116497666_116497667delGT	uc002tla.1	+						DPP10_uc002tlb.1_Intron|DPP10_uc002tlc.1_Intron|DPP10_uc002tle.2_Intron|DPP10_uc002tlf.1_Intron	NM_020868	NP_065919			dipeptidyl peptidase 10 isoform long						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
RAB3GAP1	22930	broad.mit.edu	37	2	135887668	135887668	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135887668delT	uc002tuj.2	+						RAB3GAP1_uc010fnf.2_Intron|RAB3GAP1_uc010fng.2_Intron|RAB3GAP1_uc010fnh.1_Intron	NM_012233	NP_036365			RAB3 GTPase-activating protein							centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)														---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138033617	138033617	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138033617delT	uc002tva.1	+						THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141598364	141598364	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141598364delT	uc002tvj.1	-							NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
EPC2	26122	broad.mit.edu	37	2	149542636	149542636	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149542636delT	uc010zbt.1	+							NM_015630	NP_056445			enhancer of polycomb homolog 2						chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152346394	152346394	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152346394delA	uc010fnx.2	-						NEB_uc002txr.2_Intron|RIF1_uc002txp.2_Intron|NEB_uc010zbz.1_Intron|NEB_uc002txq.2_Intron|NEB_uc010zca.1_Intron|NEB_uc010zcb.1_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152514691	152514691	+	Intron	DEL	T	-	-	rs139825807		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152514691delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
PKP4	8502	broad.mit.edu	37	2	159488063	159488063	+	Intron	DEL	T	-	-	rs75092706		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159488063delT	uc002tzv.2	+						PKP4_uc002tzt.1_Intron|PKP4_uc002tzu.2_Intron|PKP4_uc002tzw.2_Intron|PKP4_uc002tzx.2_Intron|PKP4_uc002tzy.1_Intron|PKP4_uc002tzz.1_Intron|PKP4_uc002uaa.2_Intron	NM_003628	NP_003619			plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7															HNSCC(62;0.18)			---	---	---	---
TANC1	85461	broad.mit.edu	37	2	159992541	159992562	+	Intron	DEL	GTGTGTGTGTGTGTGTGTGTGC	-	-	rs55994009	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159992541_159992562delGTGTGTGTGTGTGTGTGTGTGC	uc002uag.2	+						TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Intron|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_5'Flank	NM_033394	NP_203752			tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
MARCH7	64844	broad.mit.edu	37	2	160616015	160616016	+	Intron	DEL	TT	-	-	rs34264670		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160616015_160616016delTT	uc002uax.2	+						MARCH7_uc010foq.2_Intron|MARCH7_uc010zcn.1_Intron|MARCH7_uc010for.2_Intron|MARCH7_uc002uay.2_Intron	NM_022826	NP_073737			axotrophin								ligase activity|zinc ion binding				0																		---	---	---	---
LY75	4065	broad.mit.edu	37	2	160732257	160732257	+	Intron	DEL	A	-	-	rs75237280		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160732257delA	uc002ubc.3	-						LY75_uc002ubb.3_Intron|LY75_uc010fos.2_Intron|LY75_uc010fot.1_Intron	NM_002349	NP_002340			lymphocyte antigen 75 precursor						endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)														---	---	---	---
PLA2R1	22925	broad.mit.edu	37	2	160885499	160885499	+	Intron	DEL	A	-	-	rs80051025		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160885499delA	uc002ube.1	-						PLA2R1_uc010zcp.1_Intron|PLA2R1_uc002ubf.2_Intron	NM_007366	NP_031392			phospholipase A2 receptor 1 isoform 1 precursor						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3																		---	---	---	---
GCG	2641	broad.mit.edu	37	2	163000445	163000445	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163000445delT	uc002ucc.2	-							NM_002054	NP_002045			glucagon preproprotein						cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)													---	---	---	---
TTC21B	79809	broad.mit.edu	37	2	166756519	166756525	+	Intron	DEL	AAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166756519_166756525delAAAAAAA	uc002udk.2	-							NM_024753	NP_079029			tetratricopeptide repeat domain 21B							cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5																		---	---	---	---
SCN1A	6323	broad.mit.edu	37	2	166903618	166903618	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:166903618delT	uc010zcz.1	-						SCN1A_uc002udo.3_Intron|SCN1A_uc010fpk.2_Intron	NM_006920	NP_008851			sodium channel, voltage-gated, type I, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)													---	---	---	---
NOSTRIN	115677	broad.mit.edu	37	2	169707930	169707930	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169707930delA	uc002ueg.2	+						NOSTRIN_uc002uef.2_Intron|NOSTRIN_uc002uei.2_Intron|NOSTRIN_uc010fpu.2_Intron|NOSTRIN_uc002ueh.2_Intron|NOSTRIN_uc002uej.2_Intron	NM_001039724	NP_001034813			nitric oxide synthase trafficker isoform 2						endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0																		---	---	---	---
SSB	6741	broad.mit.edu	37	2	170665244	170665244	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170665244delA	uc002ufk.2	+						SSB_uc002ufl.2_Intron|SSB_uc002ufm.2_Intron	NM_003142	NP_003133			autoantigen La						histone mRNA metabolic process|tRNA modification	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding|tRNA binding			skin(3)|pancreas(1)	4																		---	---	---	---
MYO3B	140469	broad.mit.edu	37	2	171242866	171242866	+	Intron	DEL	T	-	-	rs67846656		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171242866delT	uc002ufy.2	+						MYO3B_uc002ufv.2_Intron|MYO3B_uc010fqb.1_Intron|MYO3B_uc002ufz.2_Intron|MYO3B_uc002ufw.2_Intron|MYO3B_uc002ufx.2_Intron|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482			myosin IIIB isoform 2						response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19																		---	---	---	---
DYNC1I2	1781	broad.mit.edu	37	2	172584624	172584625	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172584624_172584625delTT	uc002uha.1	+						DYNC1I2_uc002uhc.2_Intron|DYNC1I2_uc002uhb.1_Intron|DYNC1I2_uc010zds.1_Intron|DYNC1I2_uc002uhe.1_Intron|DYNC1I2_uc002uhf.1_Intron|DYNC1I2_uc010zdt.1_Intron|DYNC1I2_uc002uhg.1_Intron|DYNC1I2_uc010zdu.1_Intron	NM_001378	NP_001369			dynein, cytoplasmic 1, intermediate chain 2						G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.198)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	173020728	173020728	+	IGR	DEL	T	-	-	rs35217322	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173020728delT								DLX2 (53250 upstream) : ITGA6 (271354 downstream)																																			---	---	---	---
ZAK	51776	broad.mit.edu	37	2	174131511	174131512	+	3'UTR	INS	-	A	A	rs75896701		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174131511_174131512insA	uc002uhz.2	+	20					uc002uib.2_Intron	NM_016653	NP_057737			MLK-related kinase isoform 1						activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179405209	179405209	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179405209delT	uc010zfg.1	-						uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179480965	179480965	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179480965delT	uc010zfg.1	-						TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TFPI	7035	broad.mit.edu	37	2	188349023	188349023	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:188349023delA	uc002upx.2	-						TFPI_uc002upy.2_Intron|TFPI_uc002upz.2_Intron|TFPI_uc002uqa.2_Intron|TFPI_uc002uqb.2_Intron	NM_006287	NP_006278			tissue factor pathway inhibitor isoform a						blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)													---	---	---	---
GULP1	51454	broad.mit.edu	37	2	189393930	189393930	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189393930delT	uc010fru.2	+						GULP1_uc002uqc.3_Intron|GULP1_uc002uqd.2_Intron|GULP1_uc010zfw.1_Intron|GULP1_uc002uqe.2_Intron|GULP1_uc002uqf.2_Intron|GULP1_uc002uqg.2_Intron	NM_016315	NP_057399			GULP, engulfment adaptor PTB domain containing						apoptosis|lipid transport|phagocytosis, engulfment	cytoplasm|intracellular membrane-bounded organelle	signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0423)|Epithelial(96;0.158)															---	---	---	---
INPP1	3628	broad.mit.edu	37	2	191227198	191227198	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191227198delT	uc002ury.3	+						INPP1_uc010fsb.2_Intron|INPP1_uc002urx.3_Intron	NM_001128928	NP_001122400			inositol polyphosphate-1-phosphatase						signal transduction		inositol-1,4-bisphosphate 1-phosphatase activity|metal ion binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.000286)|Epithelial(96;0.0186)|all cancers(119;0.057)		Lithium(DB01356)													---	---	---	---
TMEFF2	23671	broad.mit.edu	37	2	192862831	192862831	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192862831delT	uc002utc.2	-							NM_016192	NP_057276			transmembrane protein with EGF-like and two							extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196825805	196825806	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196825805_196825806insA	uc002utj.3	-							NM_018897	NP_061720			dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196837376	196837377	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196837376_196837377insA	uc002utj.3	-							NM_018897	NP_061720			dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198968502	198968503	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198968502_198968503insT	uc010fsp.2	+						PLCL1_uc002uuv.3_Intron	NM_001114661	NP_001108133			RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;						intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
FAM126B	285172	broad.mit.edu	37	2	201881949	201881951	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201881949_201881951delTTT	uc002uws.3	-						FAM126B_uc002uwu.2_Intron|FAM126B_uc002uwv.2_Intron|FAM126B_uc002uww.1_Intron	NM_173822	NP_776183			hypothetical protein LOC285172							intracellular				ovary(1)	1																		---	---	---	---
NDUFB3	4709	broad.mit.edu	37	2	201943496	201943496	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201943496delT	uc002uwx.3	+							NM_002491	NP_002482			NADH dehydrogenase (ubiquinone) 1 beta						mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)													---	---	---	---
Unknown	0	broad.mit.edu	37	2	201967197	201967202	+	IGR	DEL	AAAAAA	-	-	rs77338628		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201967197_201967202delAAAAAA								NDUFB3 (16726 upstream) : CFLAR (13614 downstream)																																			---	---	---	---
TRAK2	66008	broad.mit.edu	37	2	202257823	202257823	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202257823delA	uc002uyb.3	-							NM_015049	NP_055864			trafficking protein, kinesin binding 2							early endosome|plasma membrane	GABA receptor binding				0																		---	---	---	---
CDK15	65061	broad.mit.edu	37	2	202711958	202711958	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202711958delT	uc002uyt.2	+						CDK15_uc010ftm.2_Intron|CDK15_uc002uys.2_Intron|CDK15_uc010ftn.1_Intron|CDK15_uc010fto.1_Intron	NM_139158	NP_631897			PFTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)													---	---	---	---
MDH1B	130752	broad.mit.edu	37	2	207604137	207604137	+	Intron	DEL	A	-	-	rs141240854		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207604137delA	uc002vbs.2	-						MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Intron|MDH1B_uc010fuj.2_Intron|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934			malate dehydrogenase 1B, NAD (soluble)						carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)														---	---	---	---
KLF7	8609	broad.mit.edu	37	2	208030440	208030440	+	5'UTR	DEL	A	-	-	rs71412410		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208030440delA	uc002vbz.1	-	1					KLF7_uc002vca.1_Intron	NM_003709	NP_003700			Kruppel-like factor 7 (ubiquitous)						regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)														---	---	---	---
PTH2R	5746	broad.mit.edu	37	2	209302245	209302245	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209302245delT	uc002vdb.2	+						PTH2R_uc010zjb.1_Intron	NM_005048	NP_005039			parathyroid hormone 2 receptor precursor							integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)														---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210545255	210545255	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210545255delT	uc002vde.1	+						MAP2_uc002vdc.1_Intron|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Intron	NM_002374	NP_002365			microtubule-associated protein 2 isoform 1						central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216285710	216285710	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216285710delA	uc002vfa.2	-						FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Intron|FN1_uc002vfj.2_Intron|FN1_uc002vfl.2_Intron	NM_212482	NP_997647			fibronectin 1 isoform 1 preproprotein						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216286749	216286750	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216286749_216286750delAA	uc002vfa.2	-						FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Intron|FN1_uc002vfj.2_Intron|FN1_uc002vfl.2_Intron	NM_212482	NP_997647			fibronectin 1 isoform 1 preproprotein						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
COL4A4	1286	broad.mit.edu	37	2	227916908	227916909	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:227916908_227916909delAA	uc010zlt.1	-							NM_000092	NP_000083			alpha 4 type IV collagen precursor						axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)														---	---	---	---
SP140L	93349	broad.mit.edu	37	2	231193355	231193355	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231193355delT	uc010fxm.1	+						SP140_uc010zma.1_Intron	NM_138402	NP_612411			SP140 nuclear body protein-like							nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1																		---	---	---	---
PTMA	5757	broad.mit.edu	37	2	232577979	232577980	+	3'UTR	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232577979_232577980insA	uc002vsc.3	+	5					PTMA_uc002vsb.3_3'UTR|PTMA_uc010zmf.1_RNA|MIR1244_hsa-mir-1244-1|MI0006379_5'Flank	NM_001099285	NP_001092755			prothymosin, alpha isoform 1						transcription, DNA-dependent	nucleus					0		Renal(207;0.0112)|all_hematologic(139;0.0315)|Acute lymphoblastic leukemia(138;0.0921)|all_lung(227;0.142)		Epithelial(121;1.75e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00221)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0139)														---	---	---	---
GIGYF2	26058	broad.mit.edu	37	2	233660685	233660685	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233660685delA	uc002vti.3	+						GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron	NM_015575	NP_056390			GRB10 interacting GYF protein 2 isoform b						cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)														---	---	---	---
GRIP2	80852	broad.mit.edu	37	3	14555758	14555759	+	Intron	INS	-	AGTT	AGTT	rs138623401	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14555758_14555759insAGTT	uc011avi.1	-						GRIP2_uc010heh.2_5'Flank|GRIP2_uc011avh.1_Intron	NM_001080423	NP_001073892			glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1																		---	---	---	---
TBC1D5	9779	broad.mit.edu	37	3	17469900	17469905	+	Intron	DEL	TGTGTA	-	-	rs140342275	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:17469900_17469905delTGTGTA	uc003cbf.2	-						TBC1D5_uc010hev.2_Intron|TBC1D5_uc003cbe.2_Intron	NM_014744	NP_055559			TBC1 domain family, member 5 isoform b							intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
KAT2B	8850	broad.mit.edu	37	3	20141236	20141237	+	Intron	DEL	TG	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20141236_20141237delTG	uc003cbq.2	+							NM_003884	NP_003875			K(lysine) acetyltransferase 2B						cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
NGLY1	55768	broad.mit.edu	37	3	25792818	25792818	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:25792818delA	uc003cdl.2	-						NGLY1_uc010hfg.2_Intron|NGLY1_uc003cdm.2_Intron|NGLY1_uc011awo.1_Intron|NGLY1_uc003cdk.2_Intron	NM_018297	NP_060767			N-glycanase 1 isoform 1						glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1																		---	---	---	---
SLC4A7	9497	broad.mit.edu	37	3	27473224	27473224	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27473224delA	uc003cdv.2	-						SLC4A7_uc011awu.1_Intron|SLC4A7_uc011awv.1_Intron|SLC4A7_uc003cdu.3_Intron|SLC4A7_uc011aww.1_Intron|SLC4A7_uc011awx.1_Intron|SLC4A7_uc011awy.1_Intron|SLC4A7_uc011awz.1_Intron|SLC4A7_uc011axa.1_Intron|SLC4A7_uc011axb.1_Intron|SLC4A7_uc010hfm.2_Intron|SLC4A7_uc003cdw.2_Intron	NM_003615	NP_003606			solute carrier family 4, sodium bicarbonate							apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
EOMES	8320	broad.mit.edu	37	3	27760548	27760549	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27760548_27760549delTT	uc003cdx.2	-						EOMES_uc003cdy.3_Intron|EOMES_uc010hfn.2_Intron|EOMES_uc011axc.1_Intron	NM_005442	NP_005433			eomesodermin						CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4																		---	---	---	---
EOMES	8320	broad.mit.edu	37	3	27761564	27761564	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27761564delA	uc003cdx.2	-						EOMES_uc003cdy.3_Intron|EOMES_uc010hfn.2_Intron|EOMES_uc011axc.1_Intron	NM_005442	NP_005433			eomesodermin						CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4																		---	---	---	---
CMTM8	152189	broad.mit.edu	37	3	32301786	32301786	+	Intron	DEL	A	-	-	rs6796318	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32301786delA	uc003cex.2	+						CMTM8_uc010hfu.2_Intron	NM_178868	NP_849199			CKLF-like MARVEL transmembrane domain containing						chemotaxis	extracellular space|integral to membrane	cytokine activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	32549855	32549856	+	IGR	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32549855_32549856delAA								CMTM6 (5452 upstream) : DYNC1LI1 (17613 downstream)																																			---	---	---	---
PDCD6IP	10015	broad.mit.edu	37	3	33877438	33877438	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33877438delT	uc003cfx.2	+						PDCD6IP_uc003cfy.2_Intron|PDCD6IP_uc011axw.1_Intron	NM_013374	NP_037506			programmed cell death 6 interacting protein						apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2																		---	---	---	---
EPM2AIP1	9852	broad.mit.edu	37	3	37032586	37032586	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37032586delA	uc003cgk.2	-	1					MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620			EPM2A interacting protein 1							endoplasmic reticulum					0																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	37238346	37238346	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37238346delA								LRRFIP2 (20495 upstream) : GOLGA4 (46392 downstream)																																			---	---	---	---
RPL14	9045	broad.mit.edu	37	3	40503034	40503034	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40503034delT	uc003ckg.2	+						RPL14_uc003ckh.2_Intron|RPL14_uc003cki.2_Intron	NM_003973	NP_003964			ribosomal protein L14						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	40740450	40740451	+	IGR	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40740450_40740451delAA								ZNF621 (159407 upstream) : CTNNB1 (495950 downstream)																																			---	---	---	---
CTNNB1	1499	broad.mit.edu	37	3	41279325	41279325	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41279325delA	uc010hia.1	+						CTNNB1_uc003ckp.2_Intron|CTNNB1_uc003ckq.2_Intron|CTNNB1_uc003ckr.2_Intron|CTNNB1_uc011azf.1_Intron|CTNNB1_uc011azg.1_Intron	NM_001904	NP_001895			beta-catenin						adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44882884	44882884	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44882884delT	uc003cnx.3	+						KIF15_uc010hiq.2_Intron|KIF15_uc010hir.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
LARS2	23395	broad.mit.edu	37	3	45561625	45561625	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45561625delT	uc003cop.1	+						LARS2_uc010hit.1_Intron	NM_015340	NP_056155			leucyl-tRNA synthetase 2, mitochondrial						leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)													---	---	---	---
FYCO1	79443	broad.mit.edu	37	3	45963180	45963181	+	3'UTR	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45963180_45963181insA	uc003cpb.3	-	18					FYCO1_uc011bal.1_3'UTR	NM_024513	NP_078789			FYVE and coiled-coil domain containing 1						transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47730746	47730746	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47730746delA	uc003crq.2	-						SMARCC1_uc011bbd.1_Intron	NM_003074	NP_003065			SWI/SNF-related matrix-associated						chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
CCDC36	339834	broad.mit.edu	37	3	49273961	49273961	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49273961delT	uc003cwk.2	+						CCDC36_uc003cwl.3_Intron|CCDC36_uc011bck.1_Intron|CCDC36_uc010hkt.2_Intron	NM_178173	NP_835467			coiled-coil domain containing 36											ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)														---	---	---	---
USP4	7375	broad.mit.edu	37	3	49318017	49318017	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49318017delA	uc003cwq.2	-						USP4_uc003cwo.2_Intron|USP4_uc003cwp.2_Intron|USP4_uc003cwr.2_Intron	NM_003363	NP_003354			ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
USP4	7375	broad.mit.edu	37	3	49343050	49343050	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49343050delA	uc003cwq.2	-						USP4_uc003cwo.2_Intron|USP4_uc003cwp.2_Intron|USP4_uc003cwr.2_Intron	NM_003363	NP_003354			ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
AMT	275	broad.mit.edu	37	3	49457336	49457336	+	Intron	DEL	A	-	-	rs34568346		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49457336delA	uc003cww.2	-						AMT_uc011bcn.1_Intron|AMT_uc003cwx.2_Intron|AMT_uc011bco.1_Intron|AMT_uc003cwy.2_Intron|AMT_uc011bcp.1_Intron|AMT_uc011bcq.1_Intron	NM_000481	NP_000472			aminomethyltransferase isoform 1 precursor						glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
RBM5	10181	broad.mit.edu	37	3	50131007	50131008	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50131007_50131008delAA	uc003cyg.2	+						RBM6_uc010hld.1_Intron|RBM6_uc010hle.1_Intron|RBM6_uc010hlf.1_Intron|RBM5_uc003cyf.2_Intron|RBM5_uc011bdj.1_Intron|RBM5_uc011bdk.1_Intron	NM_005778	NP_005769			RNA binding motif protein 5						apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
SFMBT1	51460	broad.mit.edu	37	3	52950383	52950396	+	Intron	DEL	TTTTTTTTTTTTTA	-	-	rs71087030		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52950383_52950396delTTTTTTTTTTTTTA	uc003dgf.2	-						SFMBT1_uc010hmr.2_Intron|SFMBT1_uc003dgg.2_Intron|SFMBT1_uc003dgh.2_Intron	NM_001005159	NP_001005159			Scm-like with four mbt domains 1						regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)														---	---	---	---
FAM116A	201627	broad.mit.edu	37	3	57627550	57627550	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57627550delT	uc003dja.2	-							NM_152678	NP_689891			hypothetical protein LOC201627											pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)														---	---	---	---
ARL6IP5	10550	broad.mit.edu	37	3	69153415	69153415	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:69153415delA	uc003dnr.2	+							NM_006407	NP_006398			ADP-ribosylation-like factor 6 interacting						L-glutamate transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.78e-05)|Epithelial(33;0.000818)|LUSC - Lung squamous cell carcinoma(21;0.0118)|Lung(16;0.0189)|KIRC - Kidney renal clear cell carcinoma(39;0.203)|Kidney(39;0.238)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89448278	89448281	+	Intron	DEL	AAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89448278_89448281delAAAA	uc003dqy.2	+						EPHA3_uc003dqx.1_Intron|EPHA3_uc010hon.1_Intron	NM_005233	NP_005224			ephrin receptor EphA3 isoform a precursor							extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
TBC1D23	55773	broad.mit.edu	37	3	100020836	100020836	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100020836delA	uc003dtt.2	+						TBC1D23_uc003dts.2_Intron	NM_018309	NP_060779			TBC1 domain family, member 23							intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	103257911	103257911	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:103257911delT								None (None upstream) : None (None downstream)																																			---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108173172	108173172	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108173172delA	uc003dxa.1	-							NM_014981	NP_055796			myosin, heavy polypeptide 15							myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
TMPRSS7	344805	broad.mit.edu	37	3	111794490	111794490	+	Intron	DEL	T	-	-	rs112959291		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111794490delT	uc010hqb.2	+						TMPRSS7_uc011bhr.1_Intron	NM_001042575	NP_001036040			transmembrane protease, serine 7						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2																		---	---	---	---
C3orf17	25871	broad.mit.edu	37	3	112733009	112733009	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112733009delT	uc003dzr.2	-						GTPBP8_uc011bhy.1_Intron|C3orf17_uc011bhz.1_Intron|C3orf17_uc010hqh.2_Intron|C3orf17_uc003dzt.2_Intron|C3orf17_uc003dzs.2_Intron|C3orf17_uc010hqg.2_Intron|C3orf17_uc011bia.1_Intron|C3orf17_uc003dzu.2_Intron|C3orf17_uc011bib.1_Intron|C3orf17_uc011bic.1_Intron|C3orf17_uc011bid.1_Intron	NM_015412	NP_056227			hypothetical protein LOC25871							integral to membrane					0																		---	---	---	---
MUC13	56667	broad.mit.edu	37	3	124631783	124631793	+	Intron	DEL	AAAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124631783_124631793delAAAAAAAAAAA	uc003ehq.1	-							NM_033049	NP_149038			mucin 13, epithelial transmembrane							extracellular region|integral to membrane|plasma membrane					0																		---	---	---	---
TMCC1	23023	broad.mit.edu	37	3	129547382	129547382	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129547382delA	uc003emz.3	-						TMCC1_uc010htg.2_Intron	NM_001017395	NP_001017395			transmembrane and coiled-coil domain family 1							integral to membrane				skin(1)	1																		---	---	---	---
CPNE4	131034	broad.mit.edu	37	3	131404639	131404639	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:131404639delC	uc003eok.2	-						CPNE4_uc011blq.1_Intron|CPNE4_uc003eol.2_Intron|CPNE4_uc003eom.2_Intron	NM_130808	NP_570720			copine IV											upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133359119	133359119	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133359119delA	uc003eps.2	-							NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
STAG1	10274	broad.mit.edu	37	3	136349686	136349686	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136349686delA	uc003era.1	-						STAG1_uc003erb.1_Intron|STAG1_uc003erc.1_Intron|STAG1_uc010hua.1_Intron|STAG1_uc003ere.2_Intron	NM_005862	NP_005853			stromal antigen 1						cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142402698	142402699	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142402698_142402699delTT	uc010huv.2	+						PLS1_uc003euz.2_Intron|PLS1_uc003eva.2_Intron	NM_001145319	NP_001138791			plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142423444	142423444	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142423444delA	uc010huv.2	+						PLS1_uc003euz.2_Intron|PLS1_uc003eva.2_Intron	NM_001145319	NP_001138791			plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
SR140	23350	broad.mit.edu	37	3	142733044	142733045	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142733044_142733045insA	uc003evh.1	+						SR140_uc003evi.1_Intron|SR140_uc011bnj.1_Intron|SR140_uc003evj.1_Intron|SR140_uc003evk.1_Intron	NM_001080415	NP_001073884			U2-associated SR140 protein						RNA processing	nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
SLC9A9	285195	broad.mit.edu	37	3	143513733	143513734	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:143513733_143513734insA	uc003evn.2	-						SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924			solute carrier family 9 (sodium/hydrogen						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3																		---	---	---	---
CPA3	1359	broad.mit.edu	37	3	148582960	148582961	+	5'Flank	DEL	AA	-	-	rs143382113		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148582960_148582961delAA	uc003ewm.2	+							NM_001870	NP_001861			carboxypeptidase A3 precursor						proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)															---	---	---	---
EIF2A	83939	broad.mit.edu	37	3	150285470	150285470	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150285470delT	uc003eya.2	+						SERP1_uc003exz.2_Intron|EIF2A_uc003eyb.2_Intron|EIF2A_uc003eyc.2_Intron|EIF2A_uc011bnv.1_Intron|EIF2A_uc011bnw.1_Intron|EIF2A_uc003eyd.2_Intron|uc003eye.1_Intron	NM_032025	NP_114414			eukaryotic translation initiation factor 2A						regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding				0		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
MED12L	116931	broad.mit.edu	37	3	150908389	150908389	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150908389delT	uc003eyp.2	+						MED12L_uc011bnz.1_Intron|MED12L_uc003eyn.2_Intron|MED12L_uc003eyo.2_Intron	NM_053002	NP_443728			mediator of RNA polymerase II transcription,						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
C3orf33	285315	broad.mit.edu	37	3	155493410	155493410	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155493410delT	uc003fal.1	-						C3orf33_uc003fam.1_Intron	NM_173657	NP_775928			hypothetical protein LOC285315								hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
SAMD7	344658	broad.mit.edu	37	3	169642738	169642738	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169642738delT	uc003fgd.2	+						SAMD7_uc003fge.2_Intron|SAMD7_uc011bpo.1_Intron	NM_182610	NP_872416			sterile alpha motif domain containing 7											skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)															---	---	---	---
PHC3	80012	broad.mit.edu	37	3	169889138	169889138	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169889138delA	uc010hws.1	-						PHC3_uc003fgl.2_Intron|PHC3_uc011bpq.1_Intron|PHC3_uc011bpr.1_Intron|PHC3_uc003fgm.2_Intron|PHC3_uc003fgo.1_Intron|PHC3_uc003fgp.3_Frame_Shift_Del_p.F142fs|PHC3_uc003fgq.3_Frame_Shift_Del_p.F146fs	NM_024947	NP_079223			polyhomeotic like 3						multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)															---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171431997	171431997	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171431997delA	uc003fhs.2	-						PLD1_uc003fht.2_Intron	NM_002662	NP_002653			phospholipase D1 isoform a						cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
NAALADL2	254827	broad.mit.edu	37	3	175472857	175472857	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:175472857delA	uc003fit.2	+							NM_207015	NP_996898			N-acetylated alpha-linked acidic dipeptidase 2						proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)														---	---	---	---
ABCC5	10057	broad.mit.edu	37	3	183665257	183665257	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183665257delA	uc003fmg.2	-	23	3434	c.3269delT	c.(3268-3270)TTGfs	p.L1090fs	ABCC5_uc011bqt.1_Frame_Shift_Del_p.L618fs|ABCC5_uc010hxl.2_Frame_Shift_Del_p.L1047fs	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1090	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	187141216	187141216	+	IGR	DEL	A	-	-	rs80024997		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:187141216delA								RTP4 (51849 upstream) : SST (245480 downstream)																																			---	---	---	---
ATP13A4	84239	broad.mit.edu	37	3	193185363	193185363	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193185363delT	uc003ftd.2	-						ATP13A4_uc003fte.1_Intron|ATP13A4_uc011bsr.1_Intron|ATP13A4_uc010hzi.2_5'Flank|ATP13A4_uc003ftf.3_Intron	NM_032279	NP_115655			ATPase type 13A4						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)														---	---	---	---
TNK2	10188	broad.mit.edu	37	3	195595229	195595229	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195595229delG	uc003fvu.1	-	12	2438	c.1895delC	c.(1894-1896)CCGfs	p.P632fs	TNK2_uc003fvq.1_Frame_Shift_Del_p.P39fs|TNK2_uc003fvr.1_Frame_Shift_Del_p.P157fs|TNK2_uc003fvs.1_Frame_Shift_Del_p.P664fs|TNK2_uc003fvt.1_Frame_Shift_Del_p.P710fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_3'UTR	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	632	Required for interaction with SRC.|Required for interaction with NEDD4 (By similarity).|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)													---	---	---	---
NCBP2	22916	broad.mit.edu	37	3	196664216	196664216	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196664216delA	uc003fxd.1	-						NCBP2_uc003fxb.1_Intron|NCBP2_uc011btz.1_Intron|NCBP2_uc003fxc.1_Intron|NCBP2_uc003fxe.1_Intron|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388			nuclear cap binding protein subunit 2, 20kDa						gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)														---	---	---	---
DLG1	1739	broad.mit.edu	37	3	197023514	197023514	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197023514delA	uc003fxo.3	-						DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Intron|DLG1_uc010iam.1_Intron|uc003fxq.2_5'Flank	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
IQCG	84223	broad.mit.edu	37	3	197671126	197671126	+	Intron	DEL	T	-	-	rs74574846		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197671126delT	uc003fyo.2	-						IQCG_uc003fyp.2_Intron|IQCG_uc003fyq.3_Intron	NM_001134435	NP_001127907			IQ motif containing G												0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)														---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1978235	1978235	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1978235delA	uc003gdz.3	+	21	3831	c.3655delA	c.(3655-3657)AAAfs	p.K1219fs	WHSC1_uc003geb.3_Frame_Shift_Del_p.K1219fs|WHSC1_uc003gec.3_Frame_Shift_Del_p.K1219fs|WHSC1_uc003ged.3_Frame_Shift_Del_p.K1219fs|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Frame_Shift_Del_p.K438fs|WHSC1_uc011bvh.1_Frame_Shift_Del_p.K280fs|WHSC1_uc010icf.2_Frame_Shift_Del_p.K567fs	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1219					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
POLN	353497	broad.mit.edu	37	4	2214656	2214657	+	Intron	DEL	TT	-	-	rs75183121		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2214656_2214657delTT	uc003ger.2	-						POLN_uc011bvi.1_Intron	NM_181808	NP_861524			DNA-directed DNA polymerase nu						DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
MXD4	10608	broad.mit.edu	37	4	2254067	2254067	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2254067delC	uc003geu.1	-							NM_006454	NP_006445			MAD4						negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0																		---	---	---	---
CLNK	116449	broad.mit.edu	37	4	10529731	10529731	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10529731delA	uc003gmo.3	-							NM_052964	NP_443196			mast cell immunoreceptor signal transducer						immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1																		---	---	---	---
FBXL5	26234	broad.mit.edu	37	4	15642249	15642249	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15642249delT	uc003goc.1	-						FBXL5_uc010idw.1_Intron|FBXL5_uc003gob.1_Intron|FBXL5_uc010idx.1_Intron|FBXL5_uc003god.1_Intron|FBXL5_uc010idy.1_Intron	NM_012161	NP_036293			F-box and leucine-rich repeat protein 5 isoform						iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22728828	22728828	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22728828delG	uc003gqp.3	+						GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Intron	NM_020973	NP_066024			cytosolic beta-glucosidase isoform a						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
TBC1D19	55296	broad.mit.edu	37	4	26704005	26704005	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:26704005delA	uc003gsf.3	+						TBC1D19_uc010iew.2_Intron|TBC1D19_uc011bxu.1_Intron	NM_018317	NP_060787			TBC1 domain family, member 19							intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)																---	---	---	---
LIAS	11019	broad.mit.edu	37	4	39468962	39468962	+	Intron	DEL	T	-	-	rs78228460		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39468962delT	uc003guf.2	+						LIAS_uc003gug.2_Intron|LIAS_uc003guh.2_Intron	NM_006859	NP_006850			lipoic acid synthetase isoform 1 precursor						inflammatory response|response to lipopolysaccharide|response to oxidative stress	mitochondrion	4 iron, 4 sulfur cluster binding|lipoate synthase activity|metal ion binding				0					Lipoic Acid(DB00166)													---	---	---	---
NSUN7	79730	broad.mit.edu	37	4	40763014	40763014	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40763014delT	uc003gvj.3	+						NSUN7_uc003gvh.2_Intron|NSUN7_uc003gvi.3_Intron	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0																		---	---	---	---
SLC30A9	10463	broad.mit.edu	37	4	42077582	42077582	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42077582delA	uc003gwl.2	+						SLC30A9_uc011byx.1_Intron	NM_006345	NP_006336			solute carrier family 30 (zinc transporter),						nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48608294	48608295	+	Intron	DEL	AA	-	-	rs78643963		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48608294_48608295delAA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625114	48625114	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625114delA	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FIP1L1	81608	broad.mit.edu	37	4	54325743	54325743	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54325743delT	uc003gzy.2	+	18					PDGFRA_uc003haa.2_Intron|FIP1L1_uc011bzu.1_3'UTR|FIP1L1_uc003gzz.2_3'UTR|FIP1L1_uc003hab.2_3'UTR|FIP1L1_uc003hac.2_3'UTR|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_3'UTR|FIP1L1_uc003hae.2_3'UTR	NM_030917	NP_112179			FIP1 like 1 isoform 1						mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)					T	PDGFRA	idiopathic hypereosinophilic syndrome								---	---	---	---
CEP135	9662	broad.mit.edu	37	4	56883703	56883703	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56883703delA	uc003hbi.2	+						CEP135_uc003hbj.2_Intron	NM_025009	NP_079285			centrosome protein 4						centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
PPAT	5471	broad.mit.edu	37	4	57265228	57265228	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57265228delA	uc003hbr.2	-							NM_002703	NP_002694			phosphoribosyl pyrophosphate amidotransferase						glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)													---	---	---	---
Unknown	0	broad.mit.edu	37	4	57576814	57576816	+	IGR	DEL	TAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57576814_57576816delTAA								HOPX (28942 upstream) : SPINK2 (99218 downstream)																																			---	---	---	---
UBA6	55236	broad.mit.edu	37	4	68529846	68529846	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68529846delA	uc003hdg.3	-						UBA6_uc003hdi.2_Intron|UBA6_uc003hdj.2_Intron	NM_018227	NP_060697			ubiquitin-activating enzyme E1-like 2						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0																		---	---	---	---
YTHDC1	91746	broad.mit.edu	37	4	69180110	69180110	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69180110delA	uc003hdx.2	-						YTHDC1_uc003hdy.2_Intron	NM_001031732	NP_001026902			splicing factor YT521-B isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	69444612	69444612	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69444612delT								YTHDC1 (228788 upstream) : UGT2B15 (67704 downstream)																																			---	---	---	---
BTC	685	broad.mit.edu	37	4	75681332	75681332	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75681332delC	uc003hig.2	-							NM_001729	NP_001720			betacellulin precursor						positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)															---	---	---	---
USO1	8615	broad.mit.edu	37	4	76670594	76670594	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76670594delA	uc003hiu.2	+							NM_003715	NP_003706			USO1 homolog, vesicle docking protein						intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)															---	---	---	---
FRAS1	80144	broad.mit.edu	37	4	79400506	79400506	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79400506delT	uc003hlb.2	+							NM_025074	NP_079350			Fraser syndrome 1						cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5																		---	---	---	---
RASGEF1B	153020	broad.mit.edu	37	4	82349077	82349077	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82349077delA	uc003hmi.1	-						RASGEF1B_uc003hmj.1_Intron|RASGEF1B_uc010ijq.1_Intron	NM_152545	NP_689758			RasGEF domain family, member 1B						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0																		---	---	---	---
RASGEF1B	153020	broad.mit.edu	37	4	82368530	82368530	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82368530delA	uc003hmi.1	-						RASGEF1B_uc003hmj.1_Intron|RASGEF1B_uc010ijq.1_Intron	NM_152545	NP_689758			RasGEF domain family, member 1B						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0																		---	---	---	---
TMEM150C	441027	broad.mit.edu	37	4	83416686	83416686	+	Intron	DEL	T	-	-	rs75929310		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83416686delT	uc003hmy.1	-						TMEM150C_uc011ccj.1_Intron	NM_001080506	NP_001073975			transmembrane protein 150C							integral to membrane				ovary(1)	1																		---	---	---	---
PKD2	5311	broad.mit.edu	37	4	88982958	88982958	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88982958delA	uc003hre.2	+						PKD2_uc011cdf.1_Intron|PKD2_uc011cdg.1_Intron|PKD2_uc011cdh.1_Intron	NM_000297	NP_000288			polycystin 2							basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)														---	---	---	---
FAM13A	10144	broad.mit.edu	37	4	89670709	89670709	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89670709delT	uc003hse.1	-						FAM13A_uc003hsa.1_Intron|FAM13A_uc003hsb.1_Intron|FAM13A_uc003hsd.1_Intron|FAM13A_uc003hsc.1_Intron|FAM13A_uc011cdq.1_Intron|FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsg.1_Intron|FAM13A_uc010ikr.1_Intron	NM_014883	NP_055698			family with sequence similarity 13, member A1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
SNCA	6622	broad.mit.edu	37	4	90650173	90650173	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90650173delT	uc003hsq.2	-						SNCA_uc010ikt.2_Intron|SNCA_uc003hso.2_Intron|SNCA_uc003hsp.2_Intron|SNCA_uc003hsr.2_Intron|uc011cdr.1_5'Flank	NM_001146054	NP_001139526			alpha-synuclein isoform NACP140						activation of caspase activity|anti-apoptosis|negative regulation of dopamine uptake|negative regulation of exocytosis|negative regulation of histone acetylation|negative regulation of microtubule polymerization|negative regulation of monooxygenase activity|negative regulation of norepinephrine uptake|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of serotonin uptake|negative regulation of thrombin receptor signaling pathway|negative regulation of transporter activity|positive regulation of endocytosis|positive regulation of inositol phosphate biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|positive regulation of receptor recycling|positive regulation of release of sequestered calcium ion into cytosol|receptor internalization|regulation of phospholipase activity|response to interferon-gamma|response to interleukin-1|response to iron(II) ion|response to lipopolysaccharide|response to magnesium ion|synaptic vesicle endocytosis	actin cytoskeleton|axon|cell cortex|cell junction|cytosol|fibril|growth cone|nucleus|synapse	alpha-tubulin binding|calcium ion binding|caspase inhibitor activity|dynein binding|ferrous iron binding|histone binding|Hsp70 protein binding|kinesin binding|magnesium ion binding|phosphoprotein binding|tau protein binding|zinc ion binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.42e-05)	Melatonin(DB01065)													---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96091212	96091213	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96091212_96091213delAA	uc003htp.1	-						uc003hto.2_5'Flank	NM_003728	NP_003719			unc5C precursor						apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96199633	96199633	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96199633delT	uc003htp.1	-						UNC5C_uc010ilc.1_Intron|UNC5C_uc003htq.2_Intron	NM_003728	NP_003719			unc5C precursor						apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
CENPE	1062	broad.mit.edu	37	4	104098354	104098354	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104098354delA	uc003hxb.1	-						CENPE_uc003hxc.1_Intron	NM_001813	NP_001804			centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)														---	---	---	---
ARHGEF38	54848	broad.mit.edu	37	4	106552376	106552376	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106552376delT	uc003hxu.2	+	4						NM_017700	NP_060170			hypothetical protein LOC54848						regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|breast(1)	3																		---	---	---	---
CAMK2D	817	broad.mit.edu	37	4	114473053	114473053	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114473053delT	uc003ibi.2	-						CAMK2D_uc003ibj.2_Intron|CAMK2D_uc003ibk.2_Intron|CAMK2D_uc003ibo.3_Intron|CAMK2D_uc003ibm.2_Intron|CAMK2D_uc003ibn.2_Intron|CAMK2D_uc003ibl.2_Intron	NM_001221	NP_001212			calcium/calmodulin-dependent protein kinase II						interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)														---	---	---	---
CAMK2D	817	broad.mit.edu	37	4	114473292	114473292	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114473292delA	uc003ibi.2	-						CAMK2D_uc003ibj.2_Intron|CAMK2D_uc003ibk.2_Intron|CAMK2D_uc003ibo.3_Intron|CAMK2D_uc003ibm.2_Intron|CAMK2D_uc003ibn.2_Intron|CAMK2D_uc003ibl.2_Intron	NM_001221	NP_001212			calcium/calmodulin-dependent protein kinase II						interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)														---	---	---	---
UGT8	7368	broad.mit.edu	37	4	115585067	115585067	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:115585067delT	uc003ibs.2	+						UGT8_uc003ibt.2_Intron|UGT8_uc011cge.1_Intron	NM_001128174	NP_001121646			UDP-galactose-ceramide galactosyltransferase 8						central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)														---	---	---	---
BBS7	55212	broad.mit.edu	37	4	122768876	122768876	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122768876delT	uc003ied.2	-						BBS7_uc003iee.1_Intron	NM_176824	NP_789794			Bardet-Biedl syndrome 7 protein isoform a						cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123185270	123185271	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123185270_123185271insT	uc003ieh.2	+						KIAA1109_uc003iel.1_Intron|KIAA1109_uc003iek.2_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
SMARCA5	8467	broad.mit.edu	37	4	144468476	144468476	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144468476delT	uc003ijg.2	+							NM_003601	NP_003592			SWI/SNF-related matrix-associated						CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)																	---	---	---	---
HHIP	64399	broad.mit.edu	37	4	145573685	145573685	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145573685delA	uc003ijs.1	+						HHIP_uc003ijr.1_Intron	NM_022475	NP_071920			hedgehog-interacting protein precursor							cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)														---	---	---	---
ANAPC10	10393	broad.mit.edu	37	4	146003025	146003026	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146003025_146003026delTT	uc003iju.3	-						ANAPC10_uc003ijv.3_Intron|ANAPC10_uc003ijw.3_Intron	NM_014885	NP_055700			anaphase promoting complex subunit 10						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity				0	all_hematologic(180;0.151)																	---	---	---	---
ARHGAP10	79658	broad.mit.edu	37	4	148744154	148744154	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148744154delA	uc003ilf.2	+						ARHGAP10_uc003ile.1_Intron	NM_024605	NP_078881			Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)														---	---	---	---
TMEM154	201799	broad.mit.edu	37	4	153573516	153573517	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153573516_153573517delTT	uc003imw.1	-							NM_152680	NP_689893			transmembrane protein 154 precursor							integral to membrane					0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)																---	---	---	---
FNIP2	57600	broad.mit.edu	37	4	159754866	159754866	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159754866delT	uc003iqe.3	+						FNIP2_uc003iqd.2_Frame_Shift_Del_p.G247fs	NM_020840	NP_065891			folliculin interacting protein 2						DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)														---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160259361	160259361	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160259361delA	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
KLHL2	11275	broad.mit.edu	37	4	166218560	166218561	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166218560_166218561delAA	uc003irb.2	+						KLHL2_uc011cjm.1_Intron|KLHL2_uc003irc.2_Intron|KLHL2_uc010ira.2_Intron	NM_007246	NP_009177			kelch-like 2, Mayven isoform 1						intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)														---	---	---	---
CPE	1363	broad.mit.edu	37	4	166385414	166385414	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166385414delT	uc003irg.3	+							NM_001873	NP_001864			carboxypeptidase E preproprotein						cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169336791	169336791	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169336791delA	uc003irq.3	-						DDX60L_uc003irr.1_Intron|DDX60L_uc003irs.1_Intron	NM_001012967	NP_001012985			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
C4orf27	54969	broad.mit.edu	37	4	170674660	170674660	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170674660delT	uc003isl.3	-							NM_017867	NP_060337			hypothetical protein LOC54969							nucleus				ovary(1)|pancreas(1)	2		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)														---	---	---	---
SPATA4	132851	broad.mit.edu	37	4	177116377	177116378	+	Intron	INS	-	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:177116377_177116378insG	uc003iuo.1	-							NM_144644	NP_653245			spermatogenesis associated 4						apoptosis|spermatogenesis						0		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183710620	183710620	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183710620delA	uc003ivd.1	+							NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
WWC2	80014	broad.mit.edu	37	4	184207093	184207093	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184207093delT	uc010irx.2	+						WWC2_uc003ivk.3_Intron|WWC2_uc003ivl.3_Intron|WWC2_uc010iry.2_Intron|WWC2_uc003ivn.3_Intron|WWC2_uc010irz.2_Intron|WWC2_uc003ivo.3_Intron	NM_024949	NP_079225			WW and C2 domain containing 2											ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)														---	---	---	---
PDLIM3	27295	broad.mit.edu	37	4	186456437	186456437	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186456437delC	uc003ixw.3	-						PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron|PDLIM3_uc003ixy.2_Intron|PDLIM3_uc003ixz.2_Intron	NM_014476	NP_055291			PDZ and LIM domain protein 3 isoform a							sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	190884506	190884506	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:190884506delT								FRG1 (148 upstream) : TUBB4Q (19173 downstream)																																			---	---	---	---
CLPTM1L	81037	broad.mit.edu	37	5	1321591	1321591	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1321591delT	uc003jch.2	-						CLPTM1L_uc003jcg.2_Intron	NM_030782	NP_110409			CLPTM1-like						apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)														---	---	---	---
IRX1	79192	broad.mit.edu	37	5	3599265	3599266	+	Intron	DEL	TC	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:3599265_3599266delTC	uc003jde.2	+							NM_024337	NP_077313			iroquois homeobox protein 1							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
MARCH6	10299	broad.mit.edu	37	5	10405856	10405856	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:10405856delT	uc003jet.1	+						MARCH6_uc011cmu.1_Intron|MARCH6_uc003jeu.1_Intron|MARCH6_uc011cmv.1_Intron	NM_005885	NP_005876			membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13708059	13708059	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13708059delA	uc003jfd.2	-						DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
CDH6	1004	broad.mit.edu	37	5	31267935	31267936	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31267935_31267936delTT	uc003jhe.1	+						CDH6_uc003jhd.1_Intron	NM_004932	NP_004923			cadherin 6, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7																		---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31421537	31421537	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31421537delA	uc003jhg.2	-						RNASEN_uc003jhh.2_Intron|RNASEN_uc003jhi.2_Intron	NM_013235	NP_037367			ribonuclease III, nuclear isoform 1						gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
RAI14	26064	broad.mit.edu	37	5	34803784	34803784	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34803784delA	uc003jir.2	+						RAI14_uc010iur.2_Intron|RAI14_uc011coj.1_Intron|RAI14_uc010ius.1_Intron|RAI14_uc003jis.2_Intron|RAI14_uc003jit.2_Intron|RAI14_uc011cok.1_Intron	NM_015577	NP_056392			retinoic acid induced 14 isoform a							cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)																	---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37044327	37044327	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37044327delT	uc003jkl.3	+						NIPBL_uc003jkk.3_Intron	NM_133433	NP_597677			delangin isoform A						brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
Unknown	0	broad.mit.edu	37	5	37086022	37086022	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37086022delA								NIPBL (20102 upstream) : C5orf42 (20308 downstream)																																			---	---	---	---
NUP155	9631	broad.mit.edu	37	5	37333456	37333456	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37333456delA	uc003jku.1	-						NUP155_uc003jkt.1_Intron|NUP155_uc010iuz.1_Intron	NM_153485	NP_705618			nucleoporin 155kDa isoform 1						carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
C7	730	broad.mit.edu	37	5	40931055	40931055	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:40931055delA	uc003jmh.2	+						C7_uc011cpn.1_Intron	NM_000587	NP_000578			complement component 7 precursor						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)																---	---	---	---
MOCS2	4338	broad.mit.edu	37	5	52404220	52404220	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52404220delA	uc011cqf.1	-						MOCS2_uc003joz.2_Intron|uc003jpb.1_5'Flank	NM_176806	NP_789776			molybdopterin synthase small subunit MOCS2A						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding				0		Lung NSC(810;3.08e-05)|Breast(144;0.0848)																---	---	---	---
NDUFS4	4724	broad.mit.edu	37	5	52899167	52899171	+	Intron	DEL	TTTTT	-	-	rs72062223		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52899167_52899171delTTTTT	uc003jpe.2	+							NM_002495	NP_002486			NADH dehydrogenase (ubiquinone) Fe-S protein 4						brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)													---	---	---	---
PDE4D	5144	broad.mit.edu	37	5	58570981	58570981	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:58570981delA	uc003jsa.2	-						PDE4D_uc003jrx.2_Intron|PDE4D_uc003jry.2_Intron|PDE4D_uc003jrz.2_Intron|PDE4D_uc003jsb.2_Intron|PDE4D_uc003jsc.2_Intron|PDE4D_uc003jrv.2_Intron|PDE4D_uc003jrw.2_Intron|uc003jsd.1_RNA	NM_001104631	NP_001098101			phosphodiesterase 4D isoform 1						signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)													---	---	---	---
CWC27	10283	broad.mit.edu	37	5	64181417	64181419	+	Intron	DEL	CTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64181417_64181419delCTT	uc003jtn.1	+						CWC27_uc010iwt.1_Intron	NM_005869	NP_005860			serologically defined colon cancer antigen 10						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0																		---	---	---	---
TRIM23	373	broad.mit.edu	37	5	64907243	64907243	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64907243delT	uc003jty.2	-						TRIM23_uc003jtw.2_Intron|TRIM23_uc003jtx.2_Intron	NM_001656	NP_001647			ADP-ribosylation factor domain protein 1 isoform						interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)														---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66398594	66398594	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66398594delA	uc003jut.1	+						MAST4_uc003jus.2_Intron|MAST4_uc003juu.1_Intron|MAST4_uc011cra.1_Intron|MAST4_uc010ixa.2_Intron|MAST4_uc003juv.2_Intron|MAST4_uc003juw.2_Intron	NM_015183	NP_055998			microtubule associated serine/threonine kinase							cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
RGNEF	64283	broad.mit.edu	37	5	73128058	73128058	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73128058delA	uc011csq.1	+						RGNEF_uc003kcx.2_Intron|RGNEF_uc003kcy.1_Intron|RGNEF_uc010izf.2_Intron|RGNEF_uc011csr.1_Intron	NM_001080479	NP_001073948			Rho-guanine nucleotide exchange factor						cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)														---	---	---	---
THBS4	7060	broad.mit.edu	37	5	79335822	79335822	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79335822delC	uc003kgh.2	+							NM_003248	NP_003239			thrombospondin 4 precursor						endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)														---	---	---	---
EDIL3	10085	broad.mit.edu	37	5	83550194	83550194	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:83550194delA	uc003kio.1	-						EDIL3_uc003kip.1_Intron	NM_005711	NP_005702			EGF-like repeats and discoidin I-like						cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)														---	---	---	---
LOC645323	645323	broad.mit.edu	37	5	87898998	87898998	+	Intron	DEL	A	-	-	rs11959094		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87898998delA	uc011cua.1	-							NR_015436				Homo sapiens cDNA FLJ34037 fis, clone FCBBF2005439.												0																		---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101755728	101755728	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101755728delA	uc003knn.2	-						SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Intron|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759			solute carrier organic anion transporter family,							integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102484798	102484799	+	Intron	DEL	AC	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102484798_102484799delAC	uc003kod.3	+						PPIP5K2_uc011cva.1_Intron|PPIP5K2_uc003koe.2_Intron|PPIP5K2_uc010jbo.1_Intron	NM_015216	NP_056031			Histidine acid phosphatase domain containing 1						inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118503285	118503285	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118503285delT	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
PHAX	51808	broad.mit.edu	37	5	125944333	125944333	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:125944333delA	uc003kua.1	+							NM_032177	NP_115553			RNA U, small nuclear RNA export adaptor						ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding				0																		---	---	---	---
ISOC1	51015	broad.mit.edu	37	5	128440485	128440485	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:128440485delT	uc003kva.2	+							NM_016048	NP_057132			isochorismatase domain containing 1							peroxisome	catalytic activity				0		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)														---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132439731	132439731	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132439731delT	uc003kyj.2	+							NM_002154	NP_002145			heat shock 70kDa protein 4						cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
NME5	8382	broad.mit.edu	37	5	137454718	137454718	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137454718delT	uc003lce.2	-						BRD8_uc003lcc.1_Intron	NM_003551	NP_003542			non-metastatic cells 5, protein expressed in						anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
SIL1	64374	broad.mit.edu	37	5	138371332	138371344	+	Intron	DEL	TTTTTTTTTTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138371332_138371344delTTTTTTTTTTTTT	uc003ldm.2	-						SIL1_uc003ldn.2_Intron|SIL1_uc003ldo.2_Intron|SIL1_uc003ldp.2_Intron|SIL1_uc003ldq.1_Intron	NM_022464	NP_071909			SIL1 protein precursor						intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)											Marinesco-Sj_gren_syndrome				---	---	---	---
PCDHGA11	56105	broad.mit.edu	37	5	140803318	140803318	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140803318delG	uc003lkq.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_3'UTR|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737			protocadherin gamma subfamily A, 11 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
TCERG1	10915	broad.mit.edu	37	5	145862440	145862440	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145862440delT	uc003lob.2	+						TCERG1_uc003loc.2_Intron	NM_006706	NP_006697			transcription elongation regulator 1 isoform 1						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
NDST1	3340	broad.mit.edu	37	5	149919109	149919109	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149919109delT	uc003lsk.3	+						NDST1_uc011dcj.1_Intron|NDST1_uc003lsl.2_3'UTR	NM_001543	NP_001534			N-deacetylase/N-sulfotransferase (heparan						heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(1)|skin(1)	2		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154305780	154305781	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154305780_154305781delAA	uc003lvx.3	-						GEMIN5_uc011ddk.1_Intron	NM_015465	NP_056280			gemin 5						ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
ATP10B	23120	broad.mit.edu	37	5	160025551	160025551	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:160025551delA	uc003lym.1	-						ATP10B_uc010jit.1_Intron	NM_025153	NP_079429			ATPase, class V, type 10B						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
RARS	5917	broad.mit.edu	37	5	167922640	167922640	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167922640delT	uc003lzx.2	+						RARS_uc011deo.1_Intron	NM_002887	NP_002878			arginyl-tRNA synthetase						arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)														---	---	---	---
PAK1IP1	55003	broad.mit.edu	37	6	10702474	10702476	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10702474_10702476delAAA	uc003mzg.2	+							NM_017906	NP_060376			PAK1 interacting protein 1						negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)																---	---	---	---
CAP2	10486	broad.mit.edu	37	6	17542893	17542893	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17542893delT	uc003ncb.2	+						CAP2_uc010jpk.1_Intron|CAP2_uc011dja.1_Intron|CAP2_uc011djb.1_Intron|CAP2_uc011djc.1_Intron|CAP2_uc011djd.1_Intron	NM_006366	NP_006357			adenylyl cyclase-associated protein 2						activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			ovary(1)	1	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)															---	---	---	---
BTN2A1	11120	broad.mit.edu	37	6	26465762	26465762	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26465762delA	uc003nib.1	+						BTN2A1_uc003nic.1_Intron|BTN2A1_uc003nid.1_Intron|BTN2A1_uc011dko.1_Intron|BTN2A1_uc010jqk.1_Intron	NM_007049	NP_008980			butyrophilin, subfamily 2, member A1 isoform 1						lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
MSH5	4439	broad.mit.edu	37	6	31708750	31708750	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31708750delA	uc003nwv.1	+						MSH5_uc003nwt.1_Intron|MSH5_uc003nwu.1_Intron|MSH5_uc003nww.1_Intron|MSH5_uc003nwx.1_Intron	NM_172166	NP_751898			mutS homolog 5 isoform c						chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3													Direct_reversal_of_damage|MMR					---	---	---	---
SLC26A8	116369	broad.mit.edu	37	6	35927057	35927057	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35927057delT	uc003olm.2	-						SLC26A8_uc010jwa.2_Intron|SLC26A8_uc003olk.2_Intron|SLC26A8_uc003oln.2_Intron|SLC26A8_uc003oll.2_Intron	NM_052961	NP_443193			solute carrier family 26, member 8 isoform a						cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2																		---	---	---	---
SFRS3	6428	broad.mit.edu	37	6	36568756	36568756	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36568756delT	uc003omj.2	+						SFRS3_uc003omk.2_Intron	NM_003017	NP_003008			splicing factor, arginine/serine-rich 3						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0								T	BCL6	follicular lymphoma								---	---	---	---
KIF6	221458	broad.mit.edu	37	6	39602474	39602474	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39602474delA	uc003oot.2	-						KIF6_uc010jxa.1_Intron|KIF6_uc011dua.1_Intron|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464			kinesin family member 6						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
TREML3	340206	broad.mit.edu	37	6	41185829	41185829	+	5'Flank	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41185829delT	uc003oqb.2	-							NR_027256				Homo sapiens TREM-like transcript 3 (TLT3) mRNA, partial cds.												0																		---	---	---	---
ZNF318	24149	broad.mit.edu	37	6	43320004	43320004	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43320004delA	uc003oux.2	-						ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160			zinc finger protein 318						meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)															---	---	---	---
MUT	4594	broad.mit.edu	37	6	49408202	49408202	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49408202delT	uc003ozg.3	-							NM_000255	NP_000246			methylmalonyl Coenzyme A mutase precursor						fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51918130	51918130	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51918130delG	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51946933	51946933	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51946933delA	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
FAM83B	222584	broad.mit.edu	37	6	54792182	54792182	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54792182delT	uc003pck.2	+							NM_001010872	NP_001010872			hypothetical protein LOC222584											ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)																	---	---	---	---
DST	667	broad.mit.edu	37	6	56328210	56328210	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56328210delA	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pcv.3_Intron|DST_uc003pcw.3_Intron|DST_uc003pcx.3_Intron	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
KCNQ5	56479	broad.mit.edu	37	6	73902204	73902204	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:73902204delT	uc003pgk.2	+						KCNQ5_uc011dyh.1_Intron|KCNQ5_uc011dyi.1_Intron|KCNQ5_uc010kat.2_Intron|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816			potassium voltage-gated channel, KQT-like						protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79708254	79708255	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79708254_79708255delAA	uc003pir.2	-						PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
SYNCRIP	10492	broad.mit.edu	37	6	86346559	86346559	+	Intron	DEL	A	-	-	rs116240890	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86346559delA	uc003pla.2	-						SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Intron	NM_006372	NP_006363			synaptotagmin binding, cytoplasmic RNA						CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)														---	---	---	---
SPACA1	81833	broad.mit.edu	37	6	88768360	88768360	+	Intron	DEL	A	-	-	rs77119212		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88768360delA	uc003pmn.2	+							NM_030960	NP_112222			sperm acrosome associated 1 precursor							integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)														---	---	---	---
LYRM2	57226	broad.mit.edu	37	6	90345843	90345844	+	3'UTR	INS	-	AAA	AAA	rs141237482	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90345843_90345844insAAA	uc003pnm.2	-	3					LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|LYRM2_uc010kcf.1_Intron|LYRM2_uc010kcg.2_RNA|LYRM2_uc003pnl.3_RNA	NM_020466	NP_065199			LYR motif containing 2												0		all_cancers(76;2.76e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;3.72e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0131)														---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90420247	90420247	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90420247delA	uc003pnn.1	-							NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
MAP3K7	6885	broad.mit.edu	37	6	91245899	91245899	+	Intron	DEL	T	-	-	rs35103741		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:91245899delT	uc003pnz.1	-						MAP3K7_uc003pny.1_Intron|MAP3K7_uc003poa.1_Intron|MAP3K7_uc003pob.1_Intron|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97715988	97715988	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97715988delT	uc003ppb.2	-						C6orf167_uc011eaf.1_Intron|C6orf167_uc010kcn.1_Intron|C6orf167_uc010kco.1_Intron|C6orf167_uc003ppc.2_Intron	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97730435	97730439	+	Intron	DEL	GGGGG	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97730435_97730439delGGGGG	uc003ppb.2	-						C6orf167_uc011eaf.1_5'Flank|C6orf167_uc010kcn.1_Intron|C6orf167_uc010kco.1_5'Flank|C6orf167_uc003ppc.2_5'Flank	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
SEC63	11231	broad.mit.edu	37	6	108193832	108193832	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108193832delA	uc003psc.3	-						SEC63_uc003psb.3_Intron	NM_007214	NP_009145			SEC63-like protein						protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)														---	---	---	---
ARMC2	84071	broad.mit.edu	37	6	109221042	109221042	+	Intron	DEL	A	-	-	rs9486974	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109221042delA	uc003pss.3	+						ARMC2_uc011eao.1_Intron	NM_032131	NP_115507			armadillo repeat containing 2								binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110551052	110551052	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110551052delT	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
KIAA1919	91749	broad.mit.edu	37	6	111583373	111583373	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111583373delT	uc003puv.3	+							NM_153369	NP_699200			sodium-dependent glucose transporter 1						carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(3)	3		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)														---	---	---	---
ZUFSP	221302	broad.mit.edu	37	6	116982068	116982068	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116982068delT	uc003pxf.1	-						ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499			zinc finger with UFM1-specific peptidase domain							intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)														---	---	---	---
RFX6	222546	broad.mit.edu	37	6	117237089	117237089	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117237089delA	uc003pxm.2	+							NM_173560	NP_775831			regulatory factor X, 6						glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
ENPP1	5167	broad.mit.edu	37	6	132199544	132199544	+	Intron	DEL	A	-	-	rs75833731		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132199544delA	uc011ecf.1	+							NM_006208	NP_006199			ectonucleotide pyrophosphatase/phosphodiesterase						3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)													---	---	---	---
PDE7B	27115	broad.mit.edu	37	6	136359108	136359108	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136359108delA	uc003qgp.2	+						uc003qgq.1_Intron|PDE7B_uc003qgr.2_5'Flank	NM_018945	NP_061818			phosphodiesterase 7B						signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)													---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143082717	143082717	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143082717delA	uc003qjd.2	-							NM_006734	NP_006725			human immunodeficiency virus type I enhancer						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
PHACTR2	9749	broad.mit.edu	37	6	144128096	144128099	+	Intron	DEL	AAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144128096_144128099delAAAA	uc003qjq.3	+						PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Intron|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536			phosphatase and actin regulator 2 isoform 3								actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)														---	---	---	---
IPCEF1	26034	broad.mit.edu	37	6	154538087	154538088	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:154538087_154538088insA	uc003qpx.2	-						OPRM1_uc003qpt.1_Intron|IPCEF1_uc003qpw.2_Intron|IPCEF1_uc010kjh.2_Intron	NM_015553	NP_056368			phosphoinositide-binding protein PIP3-E isoform						response to oxidative stress	cytoplasm|plasma membrane	oxygen transporter activity|peroxidase activity				0																		---	---	---	---
RBM16	22828	broad.mit.edu	37	6	155154728	155154728	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155154728delT	uc003qqa.2	+	21					TIAM2_uc003qqb.2_Intron|RBM16_uc011efj.1_3'UTR|RBM16_uc011efk.1_3'UTR|RBM16_uc003qpz.2_3'UTR	NM_014892	NP_055707			RNA-binding motif protein 16						mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)														---	---	---	---
ARID1B	57492	broad.mit.edu	37	6	157502396	157502396	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157502396delT	uc003qqn.2	+						ARID1B_uc003qqo.2_Intron|ARID1B_uc003qqp.2_Intron|ARID1B_uc010kjl.2_Intron	NM_017519	NP_059989			AT rich interactive domain 1B (SWI1-like)						chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)														---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158508009	158508009	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158508009delC	uc003qqx.1	+	23	3406	c.3331delC	c.(3331-3333)CCCfs	p.P1111fs	SYNJ2_uc003qqw.1_Frame_Shift_Del_p.P1111fs|SYNJ2_uc003qqy.1_Frame_Shift_Del_p.P824fs|SYNJ2_uc003qqz.1_Frame_Shift_Del_p.P728fs|SYNJ2_uc003qra.1_Frame_Shift_Del_p.P454fs|SYNJ2_uc010kjp.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1111	Pro-rich.|Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
SLC22A3	6581	broad.mit.edu	37	6	160868902	160868902	+	Intron	DEL	G	-	-	rs75089883	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160868902delG	uc003qti.2	+						SLC22A3_uc011efx.1_Intron	NM_021977	NP_068812			solute carrier family 22 member 3							integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)														---	---	---	---
TCP10L2	401285	broad.mit.edu	37	6	167595502	167595502	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167595502delA	uc010kkp.2	+	8						NM_001145121	NP_001138593			t-complex 10-like 2												0																		---	---	---	---
TCP10	6953	broad.mit.edu	37	6	167786551	167786551	+	Intron	DEL	T	-	-	rs146852129		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167786551delT	uc003qvu.2	-							NM_004610	NP_004601			t-complex 10							cytosol				breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)														---	---	---	---
INTS1	26173	broad.mit.edu	37	7	1527082	1527082	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1527082delC	uc003skn.2	-	20	2621	c.2520delG	c.(2518-2520)GGGfs	p.G840fs	INTS1_uc003skp.1_Frame_Shift_Del_p.G187fs	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	840					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)														---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2974028	2974028	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2974028delC	uc003smv.2	-							NM_032415	NP_115791			caspase recruitment domain family, member 11						positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4014338	4014338	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4014338delT	uc003smx.2	+							NM_152744	NP_689957			sidekick 1 precursor						cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
USP42	84132	broad.mit.edu	37	7	6156259	6156259	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6156259delT	uc011jwo.1	+						USP42_uc011jwn.1_Intron|USP42_uc010kth.1_Intron|USP42_uc011jwp.1_Intron|USP42_uc011jwq.1_Intron|USP42_uc011jwr.1_5'Flank	NM_032172	NP_115548			ubiquitin specific peptidase 42						cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)														---	---	---	---
DAGLB	221955	broad.mit.edu	37	7	6505549	6505550	+	Intron	DEL	AC	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6505549_6505550delAC	uc003sqd.3	-						KDELR2_uc003sqe.3_Intron|KDELR2_uc003sqf.3_Intron	NM_139179	NP_631918			diacylglycerol lipase, beta isoform 1						lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)														---	---	---	---
COL28A1	340267	broad.mit.edu	37	7	7516924	7516924	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7516924delA	uc003src.1	-						COL28A1_uc011jxe.1_Intron|COL28A1_uc003srd.2_Intron	NM_001037763	NP_001032852			collagen, type XXVIII precursor						cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)														---	---	---	---
MIOS	54468	broad.mit.edu	37	7	7625576	7625576	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7625576delT	uc003srf.2	+						MIOS_uc003srg.2_Intron|MIOS_uc010ktq.2_Intron	NM_019005	NP_061878			missing oocyte, meiosis regulator, homolog												0																		---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22206775	22206775	+	Intron	DEL	A	-	-	rs79048386		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22206775delA	uc011jym.1	-						RAPGEF5_uc003svg.2_Intron					Synthetic construct DNA, clone: pF1KSDA0277, Homo sapiens RAPGEF5 gene for Rap guanine nucleotide exchange factor 5, complete cds, without stop codon, in Flexi system.						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
NUPL2	11097	broad.mit.edu	37	7	23239759	23239759	+	Intron	DEL	T	-	-	rs112626242		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23239759delT	uc003svu.2	+						NUPL2_uc003svv.2_Intron|NUPL2_uc003svw.2_Intron|NUPL2_uc011jyw.1_Intron|NUPL2_uc003svx.2_Intron|NUPL2_uc011jyx.1_Intron	NM_007342	NP_031368			nucleoporin like 2						carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	26316251	26316251	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:26316251delA								CBX3 (63277 upstream) : SNX10 (15264 downstream)																																			---	---	---	---
HOXA11	3207	broad.mit.edu	37	7	27224960	27224960	+	5'Flank	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27224960delT	uc003syx.2	-						HOXA11_uc003syy.2_5'Flank|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514			homeobox A11						branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2								T	NUP98	CML						OREG0003746|OREG0003747	type=REGULATORY REGION|Gene=BC025338|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=HOXA11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
BMPER	168667	broad.mit.edu	37	7	34118338	34118338	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:34118338delT	uc011kap.1	+							NM_133468	NP_597725			BMP-binding endothelial regulator precursor						blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48427612	48427612	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48427612delT	uc003toq.2	+						ABCA13_uc010kys.1_Intron|ABCA13_uc003tos.1_Intron|ABCA13_uc010kyt.1_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
PSPH	5723	broad.mit.edu	37	7	56089056	56089056	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56089056delT	uc003trg.2	-						PSPH_uc003trh.2_Intron|PSPH_uc003tri.2_Intron|PSPH_uc003trj.2_Intron	NM_004577	NP_004568			phosphoserine phosphatase						L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
Unknown	0	broad.mit.edu	37	7	63546892	63546892	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:63546892delT								ZNF727 (7967 upstream) : ZNF735 (120689 downstream)																																			---	---	---	---
GUSB	2990	broad.mit.edu	37	7	65441319	65441319	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65441319delT	uc003tun.2	-						GUSB_uc011kdt.1_Intron|GUSB_uc010kzw.1_Intron	NM_000181	NP_000172			glucuronidase, beta precursor						glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0																		---	---	---	---
ASL	435	broad.mit.edu	37	7	65554525	65554525	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65554525delG	uc003tuo.2	+						ASL_uc003tup.2_Intron|ASL_uc003tur.2_Intron|ASL_uc003tuq.2_Intron	NM_000048	NP_000039			argininosuccinate lyase isoform 1						arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)													---	---	---	---
Unknown	0	broad.mit.edu	37	7	66071681	66071681	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66071681delT								LOC493754 (14318 upstream) : RABGEF1 (22209 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	66347834	66347834	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66347834delT								LOC729156 (38021 upstream) : C7orf42 (38369 downstream)																																			---	---	---	---
WBSCR16	81554	broad.mit.edu	37	7	74470283	74470283	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74470283delT	uc003ubr.2	-						WBSCR16_uc010lca.2_Intron|WBSCR16_uc010lcb.1_Intron	NM_030798	NP_110425			Williams-Beuren syndrome chromosome region 16												0																		---	---	---	---
MAGI2	9863	broad.mit.edu	37	7	77807188	77807188	+	Intron	DEL	A	-	-	rs113984102		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77807188delA	uc003ugx.2	-						MAGI2_uc003ugy.2_Intron|MAGI2_uc010ldx.1_Intron	NM_012301	NP_036433			membrane associated guanylate kinase, WW and PDZ							cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)																---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82531934	82531934	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82531934delA	uc003uhx.2	-						PCLO_uc003uhv.2_Intron	NM_033026	NP_149015			piccolo isoform 1						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
DMTF1	9988	broad.mit.edu	37	7	86800231	86800231	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86800231delT	uc003uih.2	+						DMTF1_uc003uii.2_Intron|DMTF1_uc003uij.2_Intron|DMTF1_uc011khb.1_Intron|DMTF1_uc003uik.2_Intron|DMTF1_uc003uil.2_Intron|DMTF1_uc003uim.1_Intron|DMTF1_uc003uin.2_Intron	NM_001142327	NP_001135799			cyclin D binding myb-like transcription factor 1						cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)																	---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91625184	91625184	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91625184delT	uc003ulg.2	+						AKAP9_uc003uld.3_3'UTR|AKAP9_uc003ule.2_Intron|AKAP9_uc003ulf.2_Intron	NM_005751	NP_005742			A-kinase anchor protein 9 isoform 2						G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92987813	92987813	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92987813delT	uc003umo.2	+	28					CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_3'UTR|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_3'UTR	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
COL1A2	1278	broad.mit.edu	37	7	94037958	94037959	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94037958_94037959insT	uc003ung.1	+						COL1A2_uc011kib.1_Intron	NM_000089	NP_000080			alpha 2 type I collagen precursor						axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)										HNSCC(75;0.22)			---	---	---	---
DYNC1I1	1780	broad.mit.edu	37	7	95434011	95434011	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95434011delT	uc003uoc.3	+						DYNC1I1_uc003uod.3_Intron|DYNC1I1_uc003uob.2_Intron|DYNC1I1_uc003uoe.3_Intron|DYNC1I1_uc010lfl.2_Intron	NM_004411	NP_004402			dynein, cytoplasmic 1, intermediate chain 1						vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)															---	---	---	---
PUS7	54517	broad.mit.edu	37	7	105146876	105146876	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105146876delT	uc003vcx.2	-						PUS7_uc010lji.2_Intron|PUS7_uc003vcy.2_Intron|PUS7_uc003vcz.1_Intron	NM_019042	NP_061915			pseudouridylate synthase 7 homolog						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1																		---	---	---	---
SLC26A3	1811	broad.mit.edu	37	7	107407972	107407972	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107407972delT	uc003ver.2	-						SLC26A3_uc003ves.2_Intron	NM_000111	NP_000102			solute carrier family 26, member 3						excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4																		---	---	---	---
LRRN3	54674	broad.mit.edu	37	7	110764636	110764637	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:110764636_110764637insA	uc003vft.3	+	4	2854_2855	c.1808_1809insA	c.(1807-1809)AGAfs	p.R603fs	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Frame_Shift_Ins_p.R603fs|LRRN3_uc003vfs.3_Frame_Shift_Ins_p.R603fs	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	603	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)														---	---	---	---
C7orf53	286006	broad.mit.edu	37	7	112126831	112126831	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112126831delA	uc011kmq.1	+						C7orf53_uc003vgl.2_Intron|C7orf53_uc003vgm.2_Intron	NM_001134468	NP_001127940			hypothetical protein LOC286006							integral to membrane				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	117523430	117523433	+	IGR	DEL	AAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117523430_117523433delAAAA								CTTNBP2 (9869 upstream) : NAA38 (300653 downstream)																																			---	---	---	---
FAM3C	10447	broad.mit.edu	37	7	121022812	121022812	+	Intron	DEL	A	-	-	rs77488516		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121022812delA	uc003vjx.2	-						FAM3C_uc010lkm.2_Intron	NM_014888	NP_055703			family with sequence similarity 3, member C						multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)																	---	---	---	---
AASS	10157	broad.mit.edu	37	7	121738971	121738971	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121738971delT	uc003vka.2	-						AASS_uc011knu.1_Intron|AASS_uc011knv.1_Intron|AASS_uc003vkb.2_Intron|AASS_uc011knw.1_Intron	NM_005763	NP_005754			aminoadipate-semialdehyde synthase precursor						protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
ARF5	381	broad.mit.edu	37	7	127230390	127230391	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127230390_127230391delTT	uc003vmb.1	+						FSCN3_uc003vmc.1_5'Flank	NM_001662	NP_001653			ADP-ribosylation factor 5						protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1																		---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138214086	138214086	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138214086delT	uc003vuc.2	+						TRIM24_uc003vub.2_Intron	NM_015905	NP_056989			transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
HIPK2	28996	broad.mit.edu	37	7	139416947	139416947	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139416947delA	uc003vvf.3	-						HIPK2_uc003vvd.3_Intron	NM_022740	NP_073577			homeodomain interacting protein kinase 2 isoform						apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)																	---	---	---	---
TBXAS1	6916	broad.mit.edu	37	7	139575203	139575203	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139575203delT	uc011kqv.1	+						TBXAS1_uc003vvh.2_Intron|TBXAS1_uc010lne.2_Intron|TBXAS1_uc011kqu.1_Intron|TBXAS1_uc003vvi.2_Intron|TBXAS1_uc003vvj.2_Intron|TBXAS1_uc011kqw.1_Intron|TBXAS1_uc011kqx.1_Intron	NM_001130966	NP_001124438			thromboxane A synthase 1, platelet isoform						hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)																	---	---	---	---
WEE2	494551	broad.mit.edu	37	7	141409028	141409028	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141409028delT	uc003vwn.2	+						FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028			WEE1 homolog 2						egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)																	---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151876745	151876751	+	Intron	DEL	GGGGGGG	-	-	rs72296975		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151876745_151876751delGGGGGGG	uc003wla.2	-						MLL3_uc003wkz.2_Intron|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
ACTR3B	57180	broad.mit.edu	37	7	152498544	152498544	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:152498544delT	uc003wle.1	+						ACTR3B_uc003wlf.1_Intron|ACTR3B_uc003wlg.1_Intron|ACTR3B_uc011kvp.1_Intron	NM_020445	NP_065178			actin-related protein 3-beta isoform 1						regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding				0		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)														---	---	---	---
PAXIP1	22976	broad.mit.edu	37	7	154754276	154754276	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154754276delA	uc003wlp.2	-						PAXIP1_uc003wlq.1_Intron|PAXIP1_uc011kvs.1_Intron	NM_007349	NP_031375			PAX interacting protein 1						DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)														---	---	---	---
PAXIP1	22976	broad.mit.edu	37	7	154782740	154782740	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154782740delA	uc003wlp.2	-	4	343	c.300delT	c.(298-300)TTTfs	p.F100fs	PAXIP1_uc003wlq.1_Frame_Shift_Del_p.L12fs|PAXIP1_uc011kvs.1_Intron	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	100	BRCT 2.|Interaction with PA1 (By similarity).				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)														---	---	---	---
INSIG1	3638	broad.mit.edu	37	7	155095427	155095428	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155095427_155095428insA	uc003wly.2	+						INSIG1_uc011kvu.1_Intron|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533			insulin induced gene 1 isoform 1						cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
RBM33	155435	broad.mit.edu	37	7	155503845	155503845	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155503845delT	uc010lqk.1	+						RBM33_uc011kvv.1_Intron	NM_053043	NP_444271			RNA binding motif protein 33								nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)														---	---	---	---
CTSB	1508	broad.mit.edu	37	8	11711114	11711114	+	Intron	DEL	T	-	-	rs34504234		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11711114delT	uc003wum.2	-						CTSB_uc011kxl.1_Intron|CTSB_uc003wun.2_Intron|CTSB_uc003wuo.2_Intron|CTSB_uc003wup.2_Intron|CTSB_uc003wuq.2_Intron|CTSB_uc010lsc.2_Intron|CTSB_uc003wur.2_Intron|CTSB_uc003wus.1_Intron|CTSB_uc003wut.1_Intron	NM_147780	NP_680090			cathepsin B preproprotein						proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity				0	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)														---	---	---	---
FAM66D	100132923	broad.mit.edu	37	8	12199198	12199199	+	Intron	DEL	TG	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12199198_12199199delTG	uc011kxp.1	+						uc003wvm.1_Intron					Homo sapiens cDNA FLJ37098 fis, clone BRACE2019004.												0																		---	---	---	---
GFRA2	2675	broad.mit.edu	37	8	21550684	21550684	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21550684delT	uc003wzu.1	-	9					GFRA2_uc003wzv.1_3'UTR|GFRA2_uc003wzw.1_3'UTR	NM_001495	NP_001486			GDNF family receptor alpha 2 isoform a							anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)														---	---	---	---
ESCO2	157570	broad.mit.edu	37	8	27646260	27646260	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27646260delA	uc003xgg.2	+						ESCO2_uc010luy.1_Intron	NM_001017420	NP_001017420			establishment of cohesion 1 homolog 2						cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)										SC_Phocomelia_syndrome				---	---	---	---
DDHD2	23259	broad.mit.edu	37	8	38099572	38099572	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38099572delA	uc003xlb.2	+						DDHD2_uc003xlc.2_Intron|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029			DDHD domain containing 2 isoform 1						lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)															---	---	---	---
POLB	5423	broad.mit.edu	37	8	42228944	42228945	+	Intron	DEL	TT	-	-	rs79893094		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42228944_42228945delTT	uc003xoz.1	+						POLB_uc003xpa.1_Intron|POLB_uc011lcs.1_Intron	NM_002690	NP_002681			DNA-directed DNA polymerase beta						DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)								DNA_polymerases_(catalytic_subunits)					---	---	---	---
Unknown	0	broad.mit.edu	37	8	47703935	47703935	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:47703935delT								None (None upstream) : BEYLA (48573 downstream)																																			---	---	---	---
LYPLA1	10434	broad.mit.edu	37	8	54965126	54965126	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:54965126delA	uc003xry.2	-						LYPLA1_uc011ldx.1_Intron|LYPLA1_uc003xrz.2_Intron	NM_006330	NP_006321			lysophospholipase 1						fatty acid metabolic process|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytosol	lysophospholipase activity|palmitoyl-(protein) hydrolase activity			central_nervous_system(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;8.48e-07)|Epithelial(17;9.29e-05)|all cancers(17;0.000689)															---	---	---	---
CA8	767	broad.mit.edu	37	8	61139553	61139553	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61139553delA	uc003xtz.1	-						CA8_uc003xua.1_Intron	NM_004056	NP_004047			carbonic anhydrase VIII						one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61714076	61714076	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61714076delT	uc003xue.2	+							NM_017780	NP_060250			chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
ASPH	444	broad.mit.edu	37	8	62538943	62538944	+	Intron	DEL	TT	-	-	rs78469859	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62538943_62538944delTT	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
GGH	8836	broad.mit.edu	37	8	63928201	63928202	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:63928201_63928202delAA	uc003xuw.2	-							NM_003878	NP_003869			gamma-glutamyl hydrolase precursor						glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)													---	---	---	---
YTHDF3	253943	broad.mit.edu	37	8	64081982	64081982	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:64081982delT	uc003xuy.2	+						YTHDF3_uc010lys.2_Intron|YTHDF3_uc003xuz.2_Intron|YTHDF3_uc003xva.2_Intron|YTHDF3_uc011len.1_Intron	NM_152758	NP_689971			YTH domain family, member 3												0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68188095	68188096	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68188095_68188096delTT	uc003xxo.1	-							NM_006421	NP_006412			brefeldin A-inhibited guanine						exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	68761381	68761381	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68761381delA								CPA6 (102761 upstream) : PREX2 (102967 downstream)																																			---	---	---	---
GDAP1	54332	broad.mit.edu	37	8	75275361	75275362	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75275361_75275362insA	uc003yah.2	+						GDAP1_uc011lfj.1_Intron|GDAP1_uc003yai.2_Intron	NM_018972	NP_061845			ganglioside-induced differentiation-associated							cytoplasm					0	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	82605746	82605747	+	IGR	INS	-	TA	TA	rs71268017		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82605746_82605747insTA								IMPA1 (7157 upstream) : SLC10A5 (146 downstream)																																			---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90936586	90936587	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90936586_90936587delTT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
DPY19L4	286148	broad.mit.edu	37	8	95768113	95768113	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95768113delA	uc003ygx.2	+							NM_181787	NP_861452			dpy-19-like 4							integral to membrane				ovary(2)	2	Breast(36;3.85e-06)																	---	---	---	---
RPL30	6156	broad.mit.edu	37	8	99054504	99054504	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99054504delT	uc003yif.2	-						RPL30_uc010mbk.1_Intron|SNORA72_uc003yig.1_5'Flank	NM_000989	NP_000980			ribosomal protein L30						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.192)															---	---	---	---
POP1	10940	broad.mit.edu	37	8	99148630	99148631	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99148630_99148631delAA	uc003yij.3	+						POP1_uc011lgv.1_Intron|POP1_uc003yik.2_Intron	NM_001145860	NP_001139332			processing of precursor 1						tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
NIPAL2	79815	broad.mit.edu	37	8	99264978	99264978	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99264978delT	uc003yil.1	-						NIPAL2_uc011lgw.1_5'Flank|NIPAL2_uc003yim.1_Intron	NM_024759	NP_079035			NIPA-like domain containing 2							integral to membrane					0																		---	---	---	---
TTC35	9694	broad.mit.edu	37	8	109462630	109462630	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:109462630delT	uc003ymw.1	+							NM_014673	NP_055488			tetratricopeptide repeat domain 35							endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110397975	110397975	+	Intron	DEL	T	-	-	rs11987766	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110397975delT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
RAD21	5885	broad.mit.edu	37	8	117869396	117869397	+	Intron	INS	-	AT	AT			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117869396_117869397insAT	uc003yod.2	-							NM_006265	NP_006256			RAD21 homolog						apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)																	---	---	---	---
FAM49B	51571	broad.mit.edu	37	8	130874724	130874724	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:130874724delT	uc003yss.2	-						FAM49B_uc003yst.2_Intron|FAM49B_uc003ysu.2_Intron|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Intron|FAM49B_uc003ysx.2_Intron|FAM49B_uc003ysy.1_Intron	NM_016623	NP_057707			hypothetical protein LOC51571												0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)															---	---	---	---
NDRG1	10397	broad.mit.edu	37	8	134292523	134292523	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134292523delA	uc003yuh.2	-						NDRG1_uc003yug.2_Intron|NDRG1_uc010mee.2_Intron|NDRG1_uc010mef.2_Intron|NDRG1_uc011ljh.1_Intron|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714			N-myc downstream regulated 1						cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141810338	141810339	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141810338_141810339delTT	uc003yvu.2	-						PTK2_uc011ljq.1_Intron|PTK2_uc003yvp.2_Intron|PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Intron|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Intron|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Intron	NM_153831	NP_722560			PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
BAI1	575	broad.mit.edu	37	8	143624813	143624814	+	Intron	INS	-	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143624813_143624814insC	uc003ywm.2	+							NM_001702	NP_001693			brain-specific angiogenesis inhibitor 1						axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
ADCK5	203054	broad.mit.edu	37	8	145608333	145608333	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145608333delG	uc003zch.2	+	3	222	c.168delG	c.(166-168)GTGfs	p.V56fs	ADCK5_uc003zcg.2_RNA	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	56	Helical; (Potential).					integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)															---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	134965	134965	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134965delT	uc003zga.3	-						CBWD1_uc010mgs.2_Intron|CBWD1_uc003zgb.3_Intron|CBWD1_uc003zgc.3_Intron|CBWD1_uc011llr.1_Intron	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2161562	2161562	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2161562delT	uc003zhc.2	+						SMARCA2_uc003zhd.2_Intron|SMARCA2_uc010mha.2_Intron|SMARCA2_uc011llw.1_Intron|SMARCA2_uc003zhf.2_Intron|SMARCA2_uc011llx.1_Intron|SMARCA2_uc003zhe.2_Intron|SMARCA2_uc003zhg.2_Intron|SMARCA2_uc010mhb.2_Intron	NM_003070	NP_003061			SWI/SNF-related matrix-associated						chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
GLDC	2731	broad.mit.edu	37	9	6533311	6533311	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6533311delA	uc003zkc.2	-							NM_000170	NP_000161			glycine dehydrogenase (decarboxylating)						glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GLDC	2731	broad.mit.edu	37	9	6602378	6602383	+	Intron	DEL	TTTTTT	-	-	rs10975676		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6602378_6602383delTTTTTT	uc003zkc.2	-							NM_000170	NP_000161			glycine dehydrogenase (decarboxylating)						glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
KDM4C	23081	broad.mit.edu	37	9	6892997	6892998	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6892997_6892998delTT	uc003zkh.2	+						KDM4C_uc010mhu.2_Intron|KDM4C_uc010mhw.2_Intron|KDM4C_uc011lmi.1_Intron|KDM4C_uc011lmj.1_Intron|KDM4C_uc003zkg.2_Intron|KDM4C_uc011lmk.1_Intron	NM_015061	NP_055876			jumonji domain containing 2C isoform 1						positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1																		---	---	---	---
TTC39B	158219	broad.mit.edu	37	9	15186697	15186697	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15186697delT	uc003zlr.1	-						TTC39B_uc003zlq.1_Intron|TTC39B_uc011lmp.1_Intron|TTC39B_uc010mie.1_Intron|TTC39B_uc011lmq.1_Intron|TTC39B_uc011lmr.1_Intron|TTC39B_uc010mif.1_3'UTR|TTC39B_uc003zlp.1_Intron	NM_152574	NP_689787			tetratricopeptide repeat domain 39B								binding			ovary(1)	1																		---	---	---	---
C9orf93	203238	broad.mit.edu	37	9	15657002	15657002	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15657002delA	uc003zmd.2	+						C9orf93_uc010mih.1_Intron|C9orf93_uc003zme.2_Intron|C9orf93_uc011lmu.1_Intron|C9orf93_uc003zmc.2_Intron	NM_173550	NP_775821			hypothetical protein LOC203238												0				GBM - Glioblastoma multiforme(50;4.84e-07)														---	---	---	---
CD72	971	broad.mit.edu	37	9	35612582	35612584	+	Intron	DEL	AAA	-	-	rs147554742		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35612582_35612584delAAA	uc003zxb.2	-						CD72_uc003zxc.1_Intron|CD72_uc010mkt.1_Intron	NM_001782	NP_001773			CD72 molecule						axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity				0			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TLN1	7094	broad.mit.edu	37	9	35725917	35725917	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35725917delT	uc003zxt.2	-						TLN1_uc003zxu.3_Intron	NM_006289	NP_006280			talin 1						axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
SMC5	23137	broad.mit.edu	37	9	72920041	72920041	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72920041delT	uc004ahr.2	+							NM_015110	NP_055925			SMC5 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	78917033	78917033	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78917033delT								PCSK5 (108695 upstream) : RFK (83400 downstream)																																			---	---	---	---
C9orf64	84267	broad.mit.edu	37	9	86559615	86559615	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86559615delT	uc004anb.2	-						C9orf64_uc004anc.2_Intron	NM_032307	NP_115683			hypothetical protein LOC84267												0																		---	---	---	---
HNRNPK	3190	broad.mit.edu	37	9	86590265	86590265	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86590265delA	uc004ang.3	-						HNRNPK_uc011lsw.1_5'UTR|HNRNPK_uc004and.3_5'UTR|HNRNPK_uc004ank.3_Intron|HNRNPK_uc004anf.3_Intron|HNRNPK_uc004anh.3_Intron|HNRNPK_uc011lsx.1_Intron|HNRNPK_uc004ani.3_Intron|HNRNPK_uc004anj.3_Intron|HNRNPK_uc004ann.3_Intron|HNRNPK_uc004anl.3_Intron|HNRNPK_uc004anm.3_Intron	NM_031262	NP_112552			heterogeneous nuclear ribonucleoprotein K						interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1																		---	---	---	---
NAA35	60560	broad.mit.edu	37	9	88593370	88593371	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88593370_88593371delAA	uc004aoi.3	+						NAA35_uc004aoj.3_Intron|NAA35_uc004aok.1_Intron	NM_024635	NP_078911			corneal wound healing-related protein						smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3																		---	---	---	---
NAA35	60560	broad.mit.edu	37	9	88618680	88618680	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88618680delT	uc004aoi.3	+						NAA35_uc004aoj.3_Intron	NM_024635	NP_078911			corneal wound healing-related protein						smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3																		---	---	---	---
DAPK1	1612	broad.mit.edu	37	9	90113866	90113866	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90113866delT	uc004apc.2	+						DAPK1_uc004ape.2_Intron|DAPK1_uc004apd.2_Intron|DAPK1_uc011ltg.1_5'Flank|DAPK1_uc011lth.1_5'Flank	NM_004938	NP_004929			death-associated protein kinase 1						apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2														Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				---	---	---	---
DAPK1	1612	broad.mit.edu	37	9	90219825	90219825	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90219825delT	uc004apc.2	+						DAPK1_uc004ape.2_Intron|DAPK1_uc004apd.2_Intron|DAPK1_uc011ltg.1_Intron|DAPK1_uc011lth.1_Intron	NM_004938	NP_004929			death-associated protein kinase 1						apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2														Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				---	---	---	---
SPIN1	10927	broad.mit.edu	37	9	91089961	91089970	+	Intron	DEL	TCTTTTTTTT	-	-	rs11320023		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91089961_91089970delTCTTTTTTTT	uc010mqj.2	+						SPIN1_uc004apy.2_Intron|SPIN1_uc004apz.2_Intron|SPIN1_uc010mqk.2_Intron	NM_006717	NP_006708			spindlin						cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0																		---	---	---	---
SECISBP2	79048	broad.mit.edu	37	9	91934385	91934385	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91934385delA	uc004aqj.1	+						SECISBP2_uc010mqn.1_Intron|SECISBP2_uc004aqi.1_Intron|SECISBP2_uc011ltk.1_Intron|SECISBP2_uc004aqk.1_Intron|SECISBP2_uc010mqo.1_Intron|SECISBP2_uc011ltl.1_Intron	NM_024077	NP_076982			SECIS binding protein 2						translation	nucleus	mRNA 3'-UTR binding			ovary(2)|skin(1)	3																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	96024397	96024397	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96024397delC	uc004ati.1	+						WNK2_uc011lud.1_Intron|WNK2_uc004atj.2_Intron|WNK2_uc004atk.2_Intron	NM_006648	NP_006639			WNK lysine deficient protein kinase 2						intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
PTCH1	5727	broad.mit.edu	37	9	98278829	98278829	+	5'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98278829delT	uc010mrr.2	-	1					PTCH1_uc004avm.3_Intron|PTCH1_uc004avo.2_5'UTR|PTCH1_uc010mrv.1_Intron|PTCH1_uc010mrw.1_RNA	NM_001083602	NP_001077071			patched isoform M						embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)												Basal_Cell_Nevus_syndrome				---	---	---	---
UGCG	7357	broad.mit.edu	37	9	114695088	114695088	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114695088delT	uc004bft.2	+							NM_003358	NP_003349			ceramide glucosyltransferase						epidermis development|glucosylceramide biosynthetic process	Golgi membrane|integral to membrane|membrane fraction	ceramide glucosyltransferase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.0433)	Miglustat(DB00419)													---	---	---	---
SUSD1	64420	broad.mit.edu	37	9	114814529	114814529	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114814529delT	uc004bfu.2	-						SUSD1_uc010mui.2_Intron|SUSD1_uc010muj.2_Intron	NM_022486	NP_071931			sushi domain containing 1 precursor							integral to membrane	calcium ion binding				0																		---	---	---	---
ROD1	9991	broad.mit.edu	37	9	115037984	115037984	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115037984delA	uc004bfw.2	-						ROD1_uc004bfv.2_Intron|ROD1_uc004bfx.2_Intron|ROD1_uc011lwu.1_Intron|ROD1_uc004bfy.2_Intron|ROD1_uc004bfz.2_Intron	NM_005156	NP_005147			ROD1 regulator of differentiation 1 isoform 1						anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
PSMD5	5711	broad.mit.edu	37	9	123591599	123591599	+	Intron	DEL	A	-	-	rs145510801	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123591599delA	uc004bko.2	-						PSMD5_uc011lye.1_Intron	NM_005047	NP_005038			proteasome 26S non-ATPase subunit 5						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding				0																		---	---	---	---
C5	727	broad.mit.edu	37	9	123719342	123719342	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123719342delA	uc004bkv.2	-							NM_001735	NP_001726			complement component 5 preproprotein						activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)													---	---	---	---
CIZ1	25792	broad.mit.edu	37	9	130950329	130950332	+	Intron	DEL	AAAA	-	-	rs72456735		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130950329_130950332delAAAA	uc004btt.2	-						CIZ1_uc004btr.2_Intron|CIZ1_uc004bts.2_Intron|CIZ1_uc011maq.1_Intron|CIZ1_uc004btu.2_Intron|CIZ1_uc011mar.1_Intron|CIZ1_uc011mas.1_Intron|CIZ1_uc004btw.2_Intron|CIZ1_uc004btv.2_Intron|CIZ1_uc004btx.2_Intron	NM_001131016	NP_001124488			CDKN1A interacting zinc finger protein 1 isoform							nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
ASS1	445	broad.mit.edu	37	9	133364630	133364633	+	Intron	DEL	TTAT	-	-	rs543048	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133364630_133364633delTTAT	uc004bzm.2	+						ASS1_uc004bzn.2_Intron|ASS1_uc010mza.2_Intron|ASS1_uc004bzo.2_Intron|ASS1_uc010mzb.2_Intron|ASS1_uc004bzp.2_Intron|ASS1_uc010mzc.2_Intron	NM_000050	NP_000041			argininosuccinate synthetase 1						arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)													---	---	---	---
FCN1	2219	broad.mit.edu	37	9	137805307	137805308	+	Intron	INS	-	G	G	rs137870421	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137805307_137805308insG	uc004cfi.2	-							NM_002003	NP_001994			ficolin 1 precursor						opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138648984	138648984	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138648984delC	uc011mdq.1	+						KCNT1_uc011mdr.1_Intron|KCNT1_uc010nbf.2_Intron|KCNT1_uc004cgo.1_Intron	NM_020822	NP_065873			potassium channel, subfamily T, member 1							membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
ABCA2	20	broad.mit.edu	37	9	139913877	139913884	+	Intron	DEL	TTTTTTTT	-	-	rs35180161		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139913877_139913884delTTTTTTTT	uc011mem.1	-						ABCA2_uc011mel.1_Intron|ABCA2_uc004ckl.1_Intron|ABCA2_uc004ckm.1_Intron|ABCA2_uc004ckn.1_5'Flank|ABCA2_uc004cko.1_Intron	NM_001606	NP_001597			ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
NELF	26012	broad.mit.edu	37	9	140344282	140344282	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140344282delA	uc004cna.2	-						C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Intron|NELF_uc010nci.2_Intron|NELF_uc011mey.1_Intron|NELF_uc011mez.1_Intron|NELF_uc004cmz.2_Intron|NELF_uc004cnc.2_Intron|NELF_uc004cnb.2_Intron	NM_001130969	NP_001124441			nasal embryonic LHRH factor isoform a							nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)														---	---	---	---
ZMYND11	10771	broad.mit.edu	37	10	226131	226131	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:226131delA	uc010pzt.1	+						ZMYND11_uc001ifk.2_Intron|ZMYND11_uc010pzu.1_Intron|ZMYND11_uc010pzv.1_Intron|ZMYND11_uc010pzw.1_Intron|ZMYND11_uc001ifm.2_Intron|ZMYND11_uc010pzx.1_Intron|ZMYND11_uc001ifn.2_Intron|ZMYND11_uc009xhg.2_Intron	NM_006624	NP_006615			zinc finger, MYND domain containing 11 isoform						cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)														---	---	---	---
LARP4B	23185	broad.mit.edu	37	10	890939	890939	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:890939delT	uc001ifs.1	-	5	528	c.487delA	c.(487-489)ACAfs	p.T163fs		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	163	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
CAMK1D	57118	broad.mit.edu	37	10	12595505	12595505	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:12595505delT	uc001ilo.2	+						CAMK1D_uc001iln.2_Intron	NM_153498	NP_705718			calcium/calmodulin-dependent protein kinase ID							calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	13199663	13199664	+	IGR	INS	-	G	G	rs112539897		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13199663_13199664insG								OPTN (19387 upstream) : MCM10 (3917 downstream)																																			---	---	---	---
DCLRE1C	64421	broad.mit.edu	37	10	14981773	14981773	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14981773delT	uc001inn.2	-						DCLRE1C_uc010qbx.1_Intron|DCLRE1C_uc001inl.2_Intron|DCLRE1C_uc009xji.2_Intron|DCLRE1C_uc001inm.2_Intron|DCLRE1C_uc001ino.2_Intron|DCLRE1C_uc009xjh.2_Intron|DCLRE1C_uc001inp.2_Intron|DCLRE1C_uc001inq.2_Intron|DCLRE1C_uc001inr.2_Intron	NM_001033855	NP_001029027			artemis protein isoform a						DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1													Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					---	---	---	---
NMT2	9397	broad.mit.edu	37	10	15171907	15171917	+	Intron	DEL	AAAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15171907_15171917delAAAAAAAAAAA	uc001inz.1	-						NMT2_uc001ioa.1_Intron|NMT2_uc009xjo.1_Intron|NMT2_uc010qbz.1_Intron	NM_004808	NP_004799			N-myristoyltransferase 2						N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1																		---	---	---	---
STAM	8027	broad.mit.edu	37	10	17756958	17756959	+	3'UTR	INS	-	C	C	rs3832661		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17756958_17756959insC	uc001ipj.1	+	14					STAM_uc009xjw.1_3'UTR	NM_003473	NP_003464			signal transducing adaptor molecule 1						cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
PLXDC2	84898	broad.mit.edu	37	10	20436538	20436538	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:20436538delA	uc001iqg.1	+						PLXDC2_uc001iqh.1_Intron|PLXDC2_uc009xkc.1_Intron	NM_032812	NP_116201			plexin domain containing 2 precursor							integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
MLLT10	8028	broad.mit.edu	37	10	21875206	21875208	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21875206_21875208delTTT	uc001iqs.2	+						MLLT10_uc001iqt.2_Intron|MLLT10_uc001iqv.2_Intron|MLLT10_uc001iqy.2_Intron|MLLT10_uc009xke.1_Intron|MLLT10_uc001iqw.1_Intron|MLLT10_uc001iqx.1_Intron|MLLT10_uc009xkf.1_Intron	NM_004641	NP_004632			myeloid/lymphoid or mixed-lineage leukemia						positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2								T	MLL|PICALM|CDK6	AL								---	---	---	---
KIAA1217	56243	broad.mit.edu	37	10	24564575	24564575	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:24564575delT	uc001iru.3	+						KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irv.1_Intron|KIAA1217_uc010qda.1_Intron|MIR603_hsa-mir-603|MI0003616_5'Flank	NM_019590	NP_062536			sickle tail isoform 1						embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7																		---	---	---	---
KIAA1217	56243	broad.mit.edu	37	10	24783676	24783676	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:24783676delT	uc001iru.3	+						KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irv.1_Intron|KIAA1217_uc010qda.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Intron|KIAA1217_uc001iry.2_Intron	NM_019590	NP_062536			sickle tail isoform 1						embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7																		---	---	---	---
EPC1	80314	broad.mit.edu	37	10	32573497	32573498	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32573497_32573498delTT	uc001iwg.1	-						EPC1_uc001iwi.3_Intron|EPC1_uc009xlt.2_Intron|EPC1_uc001iwh.1_Intron	NM_025209	NP_079485			enhancer of polycomb 1						histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34572884	34572884	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34572884delT	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	38368812	38368813	+	IGR	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38368812_38368813insT								ZNF33A (14786 upstream) : ZNF37A (14462 downstream)																																			---	---	---	---
LOC100129055	100129055	broad.mit.edu	37	10	38466932	38466932	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38466932delA	uc001izn.2	+							NR_024524				Homo sapiens cDNA clone IMAGE:4825074.												0																		---	---	---	---
BICC1	80114	broad.mit.edu	37	10	60546935	60546935	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60546935delA	uc001jki.1	+							NM_001080512	NP_001073981			bicaudal C homolog 1						multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
RTKN2	219790	broad.mit.edu	37	10	63999501	63999501	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63999501delA	uc001jlw.2	-	5	491	c.394delT	c.(394-396)TGTfs	p.C132fs	RTKN2_uc001jlx.2_Frame_Shift_Del_p.C132fs	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	132					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)																	---	---	---	---
RUFY2	55680	broad.mit.edu	37	10	70136913	70136913	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70136913delT	uc001job.2	-						RUFY2_uc001jnz.1_Intron|RUFY2_uc001joa.2_5'UTR	NM_017987	NP_060457			RUN and FYVE domain-containing 2 isoform a							nucleus	metal ion binding			ovary(1)	1																		---	---	---	---
ASCC1	51008	broad.mit.edu	37	10	73887716	73887716	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73887716delA	uc001jst.1	-						ASCC1_uc001jsr.1_Intron|ASCC1_uc001jss.1_Intron|ASCC1_uc001jsu.1_Intron|ASCC1_uc010qju.1_Intron					RecName: Full=Activating signal cointegrator 1 complex subunit 1; AltName: Full=ASC-1 complex subunit p50; AltName: Full=Trip4 complex subunit p50;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	RNA binding				0																		---	---	---	---
P4HA1	5033	broad.mit.edu	37	10	74767777	74767778	+	3'UTR	INS	-	TACA	TACA	rs145047468	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74767777_74767778insTACA	uc010qka.1	-	16					P4HA1_uc001jtg.2_3'UTR|P4HA1_uc001jth.2_3'UTR|P4HA1_uc010qkb.1_3'UTR|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067			prolyl 4-hydroxylase, alpha I subunit isoform 2							endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
ADK	132	broad.mit.edu	37	10	76153858	76153858	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76153858delT	uc001jwi.2	+						ADK_uc010qlb.1_Intron|ADK_uc001jwj.2_Intron|ADK_uc010qlc.1_Intron	NM_006721	NP_006712			adenosine kinase isoform b						purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)													---	---	---	---
FAM190B	54462	broad.mit.edu	37	10	86148861	86148865	+	Intron	DEL	TTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:86148861_86148865delTTTTT	uc001kdh.1	+						FAM190B_uc010qmd.1_Intron	NM_018999	NP_061872			granule cell antiserum positive 14											ovary(3)|skin(1)	4																		---	---	---	---
WAPAL	23063	broad.mit.edu	37	10	88212863	88212864	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88212863_88212864insA	uc001kdo.2	-						WAPAL_uc009xsv.2_Intron|WAPAL_uc001kdn.2_Intron|WAPAL_uc009xsw.2_Intron	NM_015045	NP_055860			wings apart-like homolog						cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1																		---	---	---	---
HECTD2	143279	broad.mit.edu	37	10	93258537	93258537	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93258537delA	uc001khl.2	+						LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Intron|HECTD2_uc001khm.2_Intron|HECTD2_uc009xty.1_Intron|HECTD2_uc001khn.1_Intron	NM_182765	NP_877497			HECT domain containing 2 isoform a						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1																		---	---	---	---
CPEB3	22849	broad.mit.edu	37	10	93904961	93904961	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93904961delA	uc001khw.1	-						CPEB3_uc001khu.1_Intron|CPEB3_uc001khv.1_Intron|CPEB3_uc010qnn.1_Intron	NM_014912	NP_055727			cytoplasmic polyadenylation element binding								nucleotide binding|RNA binding				0		Colorectal(252;0.0869)																---	---	---	---
MYOF	26509	broad.mit.edu	37	10	95099849	95099849	+	Intron	DEL	G	-	-	rs2761329	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95099849delG	uc001kin.2	-						MYOF_uc001kio.2_Intron|MYOF_uc009xue.2_Intron	NM_013451	NP_038479			myoferlin isoform a						blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
PIPSL	266971	broad.mit.edu	37	10	95718422	95718422	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95718422delT	uc009xuj.2	-	1						NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0																		---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96313731	96313731	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96313731delT	uc001kjt.2	+						HELLS_uc001kjs.2_Intron|HELLS_uc009xul.2_Intron|HELLS_uc009xum.2_Intron|HELLS_uc009xun.2_Intron|HELLS_uc009xuo.2_Intron|HELLS_uc001kju.2_Intron|HELLS_uc009xup.2_Intron|HELLS_uc009xuq.2_Intron|HELLS_uc009xur.2_Intron	NM_018063	NP_060533			helicase, lymphoid-specific						cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
ERLIN1	10613	broad.mit.edu	37	10	101937964	101937964	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101937964delA	uc001kqn.3	-						ERLIN1_uc001kqo.3_Intron|ERLIN1_uc010qpm.1_Intron	NM_006459	NP_006450			ER lipid raft associated 1						ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding				0		Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)														---	---	---	---
ARL3	403	broad.mit.edu	37	10	104449587	104449588	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104449587_104449588delAA	uc001kwa.2	-							NM_004311	NP_004302			ADP-ribosylation factor-like 3						cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)														---	---	---	---
SLK	9748	broad.mit.edu	37	10	105768158	105768158	+	Intron	DEL	A	-	-	rs805664	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105768158delA	uc001kxo.1	+						SLK_uc001kxp.1_Intron	NM_014720	NP_055535			serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)														---	---	---	---
PDCD4	27250	broad.mit.edu	37	10	112657654	112657655	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112657654_112657655delTT	uc001kzh.2	+						PDCD4_uc001kzg.2_Intron|PDCD4_uc010qre.1_Intron	NM_014456	NP_055271			programmed cell death 4 isoform 1						apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	122114194	122114194	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:122114194delT								SEC23IP (412949 upstream) : PPAPDC1A (102272 downstream)																																			---	---	---	---
FGFR2	2263	broad.mit.edu	37	10	123263119	123263120	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123263119_123263120delTT	uc010qtk.1	-						FGFR2_uc010qtg.1_Intron|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Intron|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Intron|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfg.3_Intron	NM_000141	NP_000132			fibroblast growth factor receptor 2 isoform 1						angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				---	---	---	---
BUB3	9184	broad.mit.edu	37	10	124920172	124920172	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124920172delT	uc001lhe.2	+						BUB3_uc009yah.2_Intron|BUB3_uc001lhf.3_Intron|BUB3_uc001lhd.2_Intron|BUB3_uc010qud.1_Intron	NM_004725	NP_004716			budding uninhibited by benzimidazoles 3 isoform						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			ovary(1)	1		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)																---	---	---	---
BUB3	9184	broad.mit.edu	37	10	124923500	124923500	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124923500delT	uc001lhe.2	+	8					BUB3_uc001lhf.3_3'UTR|BUB3_uc001lhd.2_Intron|BUB3_uc010qud.1_3'UTR	NM_004725	NP_004716			budding uninhibited by benzimidazoles 3 isoform						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			ovary(1)	1		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)																---	---	---	---
CTBP2	1488	broad.mit.edu	37	10	126715243	126715244	+	Intron	INS	-	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126715243_126715244insC	uc009yak.2	-						CTBP2_uc009yal.2_Intron|CTBP2_uc001lif.3_Intron|CTBP2_uc001lih.3_Intron|CTBP2_uc001lie.3_Frame_Shift_Ins_p.G362fs	NM_001329	NP_001320			C-terminal binding protein 2 isoform 1						negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)														---	---	---	---
MRPL17	63875	broad.mit.edu	37	11	6703180	6703180	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6703180delT	uc001men.2	-	3						NM_022061	NP_071344			mitochondrial ribosomal protein L17 precursor						translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	9628209	9628209	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9628209delA								WEE1 (16898 upstream) : SWAP70 (57419 downstream)																																			---	---	---	---
CTR9	9646	broad.mit.edu	37	11	10793919	10793919	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:10793919delA	uc001mja.2	+							NM_014633	NP_055448			SH2 domain binding protein 1						histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				ovary(2)	2				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)														---	---	---	---
SOX6	55553	broad.mit.edu	37	11	16208191	16208191	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:16208191delT	uc001mme.2	-						SOX6_uc001mmd.2_Intron|SOX6_uc001mmf.2_Intron|SOX6_uc001mmg.2_Intron	NM_001145819	NP_001139291			SRY (sex determining region Y)-box 6 isoform 4						muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3																		---	---	---	---
PLEKHA7	144100	broad.mit.edu	37	11	17035645	17035645	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17035645delC	uc001mmo.2	-						PLEKHA7_uc010rcu.1_Intron	NM_175058	NP_778228			pleckstrin homology domain containing, family A						epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3																		---	---	---	---
HPS5	11234	broad.mit.edu	37	11	18308089	18308089	+	Intron	DEL	A	-	-	rs76467437		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18308089delA	uc001mod.1	-						HPS5_uc001moe.1_Intron|HPS5_uc001mof.1_Intron	NM_181507	NP_852608			Hermansky-Pudlak syndrome 5 isoform a							cytosol				ovary(1)|pancreas(1)|skin(1)	3														Hermansky-Pudlak_syndrome				---	---	---	---
IGSF22	283284	broad.mit.edu	37	11	18741911	18741913	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18741911_18741913delTTT	uc009yht.2	-						IGSF22_uc001mpa.2_Intron	NM_173588	NP_775859			immunoglobulin superfamily, member 22											ovary(4)|large_intestine(2)|kidney(1)	7																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	18894524	18894524	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18894524delT								PTPN5 (81135 upstream) : MRGPRX1 (60837 downstream)																																			---	---	---	---
ANO5	203859	broad.mit.edu	37	11	22233000	22233000	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:22233000delA	uc001mqi.2	+						ANO5_uc001mqj.2_Intron	NM_213599	NP_998764			anoctamin 5 isoform a							chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
PAX6	5080	broad.mit.edu	37	11	31823609	31823609	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31823609delA	uc001mtd.3	-						PAX6_uc001mte.3_Intron|PAX6_uc001mtg.3_Intron|PAX6_uc001mtf.3_Intron|PAX6_uc001mth.3_Intron|PAX6_uc009yjr.2_Intron	NM_001127612	NP_001121084			paired box gene 6 isoform a						blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)													Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				---	---	---	---
AMBRA1	55626	broad.mit.edu	37	11	46450142	46450143	+	Intron	INS	-	T	T	rs2864834	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46450142_46450143insT	uc010rgu.1	-						AMBRA1_uc010rgt.1_Intron|AMBRA1_uc009ylc.1_Intron|AMBRA1_uc001ncu.1_Intron|AMBRA1_uc001ncv.2_Intron|AMBRA1_uc001ncw.2_Intron|AMBRA1_uc001ncx.2_Intron	NM_017749	NP_060219			activating molecule in beclin-1-regulated						autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)														---	---	---	---
CELF1	10658	broad.mit.edu	37	11	47505271	47505272	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47505271_47505272delAA	uc001nfl.2	-						CELF1_uc001nfm.2_Intron|CELF1_uc001nfn.2_Intron|CELF1_uc001nfo.1_Intron|CELF1_uc010rhm.1_Intron|CELF1_uc001nfp.2_Intron|CELF1_uc001nfq.1_Intron|CELF1_uc001nfr.1_Intron	NM_001025596	NP_001020767			CUG triplet repeat, RNA-binding protein 1						embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47841147	47841147	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47841147delT	uc001ngm.2	-						NUP160_uc009ylw.2_Intron	NM_015231	NP_056046			nucleoporin 160kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
MS4A1	931	broad.mit.edu	37	11	60234653	60234655	+	Intron	DEL	AAT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60234653_60234655delAAT	uc001npp.2	+						MS4A1_uc001npq.2_Intron|MS4A1_uc009yna.2_Intron|MS4A1_uc009ymz.2_Intron|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605			membrane-spanning 4-domains, subfamily A, member						B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)													---	---	---	---
OTUB1	55611	broad.mit.edu	37	11	63765136	63765136	+	3'UTR	DEL	C	-	-	rs35556442		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63765136delC	uc001nyf.1	+	7					OTUB1_uc001nyg.1_3'UTR|OTUB1_uc010rmz.1_3'UTR|OTUB1_uc010rna.1_3'UTR|OTUB1_uc009ypa.2_3'UTR|OTUB1_uc009ypb.1_3'UTR	NM_017670	NP_060140			otubain 1						protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)	1																		---	---	---	---
SLC29A2	3177	broad.mit.edu	37	11	66131975	66131983	+	Intron	DEL	TTTTTTTTT	-	-	rs34482391		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66131975_66131983delTTTTTTTTT	uc001oht.2	-						SLC29A2_uc001ohs.2_Intron|SLC29A2_uc010rpb.1_Intron|SLC29A2_uc009yrf.2_Intron|SLC29A2_uc001ohu.2_Intron|SLC29A2_uc001ohv.2_Intron	NM_001532	NP_001523			solute carrier family 29 (nucleoside						cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1																		---	---	---	---
RBM4	5936	broad.mit.edu	37	11	66410772	66410773	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66410772_66410773delTT	uc009yrj.2	+						RBM4_uc009yrk.2_Intron|RBM4_uc001oiw.1_Intron|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Intron|RBM4_uc001oiz.1_Intron	NM_002896	NP_002887			RNA binding motif protein 4						circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)														---	---	---	---
CORO1B	57175	broad.mit.edu	37	11	67209168	67209168	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67209168delG	uc001olj.1	-						CORO1B_uc009yrs.1_Intron|CORO1B_uc001olk.1_Intron|CORO1B_uc009yrt.1_Intron|CORO1B_uc009yru.1_Intron|CORO1B_uc001oll.1_Intron|CORO1B_uc010rps.1_Intron|CORO1B_uc009yrv.1_Frame_Shift_Del_p.H164fs	NM_020441	NP_065174			coronin, actin binding protein, 1B						actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)															---	---	---	---
MTL5	9633	broad.mit.edu	37	11	68512434	68512434	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68512434delT	uc001ooc.2	-						MTL5_uc001ood.1_Intron|MTL5_uc009ysi.1_Intron	NM_004923	NP_004914			metallothionein-like 5, testis-specific isoform						cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)															---	---	---	---
ANO1	55107	broad.mit.edu	37	11	69949371	69949371	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69949371delA	uc001opj.2	+						ANO1_uc001opk.1_Intron|ANO1_uc001opl.1_Intron	NM_018043	NP_060513			anoctamin 1, calcium activated chloride channel						multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2																		---	---	---	---
CTTN	2017	broad.mit.edu	37	11	70281531	70281532	+	3'UTR	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70281531_70281532delTT	uc001opv.3	+	18					CTTN_uc001opu.2_Intron|CTTN_uc001opw.3_3'UTR|CTTN_uc010rqm.1_Intron|CTTN_uc001opx.2_3'UTR	NM_005231	NP_005222			cortactin isoform a							cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)														---	---	---	---
RNF169	254225	broad.mit.edu	37	11	74457267	74457267	+	5'Flank	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74457267delT	uc001ovl.3	+							NM_001098638	NP_001092108			ring finger protein 169								zinc ion binding			ovary(1)	1																		---	---	---	---
PCF11	51585	broad.mit.edu	37	11	82877219	82877219	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82877219delA	uc001ozx.3	+	5	1625	c.1280delA	c.(1279-1281)GAAfs	p.E427fs	PCF11_uc010rsu.1_Frame_Shift_Del_p.E427fs	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	427	Lys-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1																		---	---	---	---
CCDC90B	60492	broad.mit.edu	37	11	82989635	82989635	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82989635delT	uc001pae.2	-						CCDC90B_uc001pac.2_Intron|CCDC90B_uc001pad.2_Intron|CCDC90B_uc001paf.2_Intron	NM_021825	NP_068597			coiled-coil domain containing 90B precursor							integral to membrane|mitochondrion|mitochondrion					0		Acute lymphoblastic leukemia(157;0.103)																---	---	---	---
Unknown	0	broad.mit.edu	37	11	89804129	89804129	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89804129delT								TRIM64 (96891 upstream) : UBTFL1 (14989 downstream)																																			---	---	---	---
MAML2	84441	broad.mit.edu	37	11	95718643	95718643	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95718643delT	uc001pfw.1	-							NM_032427	NP_115803			mastermind-like 2						Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)						T	MECT1|CRTC3	salivary gland mucoepidermoid								---	---	---	---
CCDC82	79780	broad.mit.edu	37	11	96104412	96104412	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:96104412delA	uc009ywp.2	-						CCDC82_uc009ywq.2_Intron|CCDC82_uc001pfx.3_Intron|CCDC82_uc009ywr.2_Intron	NM_024725	NP_079001			coiled-coil domain containing 82								protein binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)														---	---	---	---
CNTN5	53942	broad.mit.edu	37	11	99942594	99942594	+	Intron	DEL	A	-	-	rs76748292		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:99942594delA	uc001pga.2	+						CNTN5_uc009ywv.1_Intron|CNTN5_uc001pfz.2_Intron|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176			contactin 5 isoform long						cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)														---	---	---	---
DCUN1D5	84259	broad.mit.edu	37	11	102936894	102936895	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102936894_102936895insT	uc001phm.2	-						DCUN1D5_uc010ruw.1_Intron	NM_032299	NP_115675			DCN1, defective in cullin neddylation 1, domain												0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)														---	---	---	---
CWF19L2	143884	broad.mit.edu	37	11	107299328	107299330	+	Intron	DEL	AAA	-	-	rs35070417		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107299328_107299330delAAA	uc010rvp.1	-						CWF19L2_uc001pjh.3_Intron|CWF19L2_uc009yxo.2_Intron	NM_152434	NP_689647			CWF19-like 2, cell cycle control								catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)														---	---	---	---
ELMOD1	55531	broad.mit.edu	37	11	107518030	107518030	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107518030delT	uc010rvs.1	+						ELMOD1_uc001pjm.2_Intron|ELMOD1_uc010rvt.1_Intron	NM_018712	NP_061182			ELMO/CED-12 domain containing 1 isoform 1						phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)														---	---	---	---
EXPH5	23086	broad.mit.edu	37	11	108412216	108412216	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108412216delT	uc001pkk.2	-						EXPH5_uc010rwa.1_Intron	NM_015065	NP_055880			exophilin 5 isoform a						intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)														---	---	---	---
ARHGAP20	57569	broad.mit.edu	37	11	110561521	110561521	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110561521delA	uc001pkz.1	-						ARHGAP20_uc001pky.1_Intron|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860			Rho GTPase activating protein 20						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116906807	116906808	+	Intron	DEL	TT	-	-	rs77063239		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116906807_116906808delTT	uc001ppy.2	-						SIK3_uc001ppz.2_Intron|SIK3_uc001pqa.2_Intron	NM_025164	NP_079440			serine/threonine-protein kinase QSK							cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
CD3E	916	broad.mit.edu	37	11	118185259	118185259	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118185259delG	uc001psq.3	+							NM_000733	NP_000724			CD3E antigen, epsilon polypeptide precursor						G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)													---	---	---	---
TREH	11181	broad.mit.edu	37	11	118529408	118529408	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118529408delC	uc001pty.1	-	14	1625	c.1580delG	c.(1579-1581)GGAfs	p.G527fs	TREH_uc009zaj.1_Frame_Shift_Del_p.G496fs|TREH_uc001ptz.1_Frame_Shift_Del_p.G404fs	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	527					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)														---	---	---	---
CBL	867	broad.mit.edu	37	11	119149127	119149127	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119149127delT	uc001pwe.2	+							NM_005188	NP_005179			Cas-Br-M (murine) ecotropic retroviral						epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.G397_I429del(1)|p.E366_K477del(1)		haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)										CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				---	---	---	---
VWA5A	4013	broad.mit.edu	37	11	124013490	124013490	+	Intron	DEL	T	-	-	rs111751268		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124013490delT	uc001pzu.2	+						VWA5A_uc001pzt.2_Intron	NM_001130142	NP_001123614			BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
PKNOX2	63876	broad.mit.edu	37	11	125301354	125301354	+	3'UTR	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125301354delG	uc001qbu.2	+	13					PKNOX2_uc010saz.1_3'UTR|PKNOX2_uc010sba.1_3'UTR|PKNOX2_uc010sbb.1_3'UTR|PKNOX2_uc001qbv.2_3'UTR	NM_022062	NP_071345			PBX/knotted 1 homeobox 2							nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)														---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2656469	2656469	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2656469delT	uc009zdu.1	+						CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Intron|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc009zdy.1_Intron|CACNA1C_uc001qkv.1_Intron	NM_199460	NP_955630			calcium channel, voltage-dependent, L type,						axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
PARP11	57097	broad.mit.edu	37	12	3938064	3938064	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3938064delA	uc001qmk.1	-						PARP11_uc001qml.2_Intron|PARP11_uc009zef.2_Intron|PARP11_uc001qmm.2_Intron|PARP11_uc001qmn.2_Intron	NM_020367	NP_065100			poly (ADP-ribose) polymerase family, member 11								NAD+ ADP-ribosyltransferase activity			ovary(1)|central_nervous_system(1)	2			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)															---	---	---	---
CD163	9332	broad.mit.edu	37	12	7633663	7633663	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7633663delT	uc001qsz.3	-						CD163_uc001qta.3_Intron|CD163_uc009zfw.2_Intron	NM_004244	NP_004235			CD163 antigen isoform a						acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8																		---	---	---	---
LRP6	4040	broad.mit.edu	37	12	12273985	12273985	+	3'UTR	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:12273985delC	uc001rah.3	-	23					BCL2L14_uc001raf.1_Intron	NM_002336	NP_002327			low density lipoprotein receptor-related protein						cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)																---	---	---	---
PTPRO	5800	broad.mit.edu	37	12	15739654	15739654	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15739654delT	uc001rcv.1	+						PTPRO_uc001rcw.1_Intron|PTPRO_uc001rcx.1_Intron|PTPRO_uc001rcy.1_Intron|PTPRO_uc001rcz.1_Intron|PTPRO_uc001rda.1_Intron	NM_030667	NP_109592			receptor-type protein tyrosine phosphatase O							integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)																---	---	---	---
SLCO1B1	10599	broad.mit.edu	37	12	21327320	21327320	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21327320delT	uc001req.3	+							NM_006446	NP_006437			solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)													---	---	---	---
ETNK1	55500	broad.mit.edu	37	12	22826417	22826417	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22826417delT	uc001rft.2	+						ETNK1_uc009ziz.2_Intron	NM_018638	NP_061108			ethanolamine kinase 1 isoform A						phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0																		---	---	---	---
CASC1	55259	broad.mit.edu	37	12	25302484	25302484	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:25302484delA	uc001rgl.2	-						CASC1_uc001rgk.2_Intron|CASC1_uc001rgm.3_Intron|CASC1_uc001rgj.2_Intron|CASC1_uc010sje.1_Intron|CASC1_uc010sjf.1_Intron|CASC1_uc010sjg.1_Intron	NM_001082973	NP_001076442			cancer susceptibility candidate 1 isoform b											ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)															---	---	---	---
ERGIC2	51290	broad.mit.edu	37	12	29494269	29494270	+	Intron	DEL	TC	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29494269_29494270delTC	uc001riv.2	-						ERGIC2_uc001riw.2_Intron	NM_016570	NP_057654			PTX1 protein						vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				ovary(1)	1	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)													---	---	---	---
CNTN1	1272	broad.mit.edu	37	12	41407971	41407971	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41407971delA	uc001rmm.1	+						CNTN1_uc001rmn.1_Intron	NM_001843	NP_001834			contactin 1 isoform 1 precursor						axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)																---	---	---	---
PUS7L	83448	broad.mit.edu	37	12	44130669	44130673	+	Intron	DEL	AAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44130669_44130673delAAAAA	uc001rnq.3	-						PUS7L_uc001rnr.3_Intron|PUS7L_uc001rns.3_Intron|PUS7L_uc009zkb.2_Intron	NM_001098615	NP_001092085			pseudouridylate synthase 7 homolog (S.						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)														---	---	---	---
SLC38A4	55089	broad.mit.edu	37	12	47170830	47170830	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47170830delA	uc001rpi.2	-						SLC38A4_uc001rpj.2_Intron	NM_018018	NP_060488			solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)																	---	---	---	---
COL2A1	1280	broad.mit.edu	37	12	48372681	48372681	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48372681delC	uc001rqu.2	-						COL2A1_uc009zkw.2_Intron|COL2A1_uc001rqv.2_Intron	NM_001844	NP_001835			collagen, type II, alpha 1 isoform 1 precursor						axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)													---	---	---	---
ZNF641	121274	broad.mit.edu	37	12	48738938	48738938	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48738938delT	uc001rrn.1	-						ZNF641_uc001rro.1_Intron|ZNF641_uc010sls.1_Intron	NM_152320	NP_689533			zinc finger protein 641						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
C12orf41	54934	broad.mit.edu	37	12	49073044	49073045	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49073044_49073045delAA	uc001rrx.2	-						C12orf41_uc001rrw.2_Intron|C12orf41_uc001rrz.2_Intron|C12orf41_uc001rry.2_Intron	NM_017822	NP_060292			hypothetical protein LOC54934											ovary(2)	2																		---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49434492	49434492	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49434492delG	uc001rta.3	-	31	7061	c.7061delC	c.(7060-7062)CCTfs	p.P2354fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2354	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
MIR1293	100302220	broad.mit.edu	37	12	50627995	50627999	+	RNA	DEL	TTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50627995_50627999delTTTTT	hsa-mir-1293|MI0006355	-						LIMA1_uc001rwj.3_Intron|LIMA1_uc001rwk.3_Intron|LIMA1_uc010smr.1_Intron|LIMA1_uc010sms.1_Intron																	0																		---	---	---	---
KRT83	3889	broad.mit.edu	37	12	52711957	52711957	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52711957delT	uc001saf.2	-							NM_002282	NP_002273			keratin 83						epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)														---	---	---	---
HOXC4	3221	broad.mit.edu	37	12	54448168	54448168	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54448168delC	uc001seu.2	+						HOXC4_uc001sex.2_Intron	NM_014620	NP_055435			homeobox C4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
OR6C76	390326	broad.mit.edu	37	12	55819935	55819935	+	5'Flank	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55819935delA	uc010spm.1	+							NM_001005183	NP_001005183			olfactory receptor, family 6, subfamily C,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
TIMELESS	8914	broad.mit.edu	37	12	56824461	56824461	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56824461delT	uc001slf.2	-						TIMELESS_uc001slg.2_Intron	NM_003920	NP_003911			timeless homolog						cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8																		---	---	---	---
KIF5A	3798	broad.mit.edu	37	12	57975862	57975862	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57975862delA	uc001sor.1	+						KIF5A_uc010srr.1_Intron|uc001sos.2_5'Flank	NM_004984	NP_004975			kinesin family member 5A						blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3																		---	---	---	---
TMEM19	55266	broad.mit.edu	37	12	72080802	72080802	+	Intron	DEL	T	-	-	rs34090337		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72080802delT	uc001sws.2	+						TMEM19_uc001swr.1_Intron|TMEM19_uc009zru.1_Intron	NM_018279	NP_060749			transmembrane protein 19							integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)														---	---	---	---
ZDHHC17	23390	broad.mit.edu	37	12	77208903	77208903	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77208903delT	uc001syk.1	+						ZDHHC17_uc001syi.1_Intron|ZDHHC17_uc001syj.2_Intron	NM_015336	NP_056151			huntingtin interacting protein 14						lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0																		---	---	---	---
PAWR	5074	broad.mit.edu	37	12	79988067	79988067	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:79988067delA	uc001syx.2	-							NM_002583	NP_002574			PRKC, apoptosis, WT1, regulator						actin filament bundle assembly|apoptosis|induction of apoptosis|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	actin binding|enzyme binding|leucine zipper domain binding|transcription corepressor activity				0																		---	---	---	---
TMTC2	160335	broad.mit.edu	37	12	83455490	83455490	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:83455490delT	uc001szt.2	+						TMTC2_uc010suk.1_Intron	NM_152588	NP_689801			transmembrane and tetratricopeptide repeat							endoplasmic reticulum|integral to membrane	binding			ovary(2)	2																		---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85554294	85554294	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85554294delT	uc001tac.2	+							NM_001079910	NP_001073379			leucine-rich repeats and IQ motif containing 1											ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
KITLG	4254	broad.mit.edu	37	12	88926063	88926063	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88926063delA	uc001tav.2	-						KITLG_uc001taw.2_Intron|KITLG_uc009zso.1_Intron	NM_000899	NP_000890			KIT ligand isoform b precursor						cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1														Testicular_Cancer_Familial_Clustering_of				---	---	---	---
CCDC41	51134	broad.mit.edu	37	12	94703662	94703662	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94703662delT	uc001tdd.2	-						CCDC41_uc001tde.2_Intron	NM_016122	NP_057206			NY-REN-58 antigen												0																		---	---	---	---
FGD6	55785	broad.mit.edu	37	12	95475462	95475466	+	Intron	DEL	TTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95475462_95475466delTTTTT	uc001tdp.3	-						FGD6_uc009zsx.2_Intron	NM_018351	NP_060821			FYVE, RhoGEF and PH domain containing 6						actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96330081	96330081	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96330081delT	uc001tek.1	-							NM_182496	NP_872302			coiled-coil domain containing 38											skin(1)	1																		---	---	---	---
C12orf63	374467	broad.mit.edu	37	12	97073209	97073209	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97073209delA	uc001tet.1	+							NM_198520	NP_940922			hypothetical protein LOC374467											skin(6)|ovary(1)	7																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	98073980	98073980	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98073980delA								RMST (115187 upstream) : LOC100128191 (832773 downstream)																																			---	---	---	---
UTP20	27340	broad.mit.edu	37	12	101769713	101769713	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101769713delA	uc001tia.1	+							NM_014503	NP_055318			down-regulated in metastasis						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4																		---	---	---	---
CCDC53	51019	broad.mit.edu	37	12	102433477	102433478	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102433477_102433478delTT	uc010svw.1	-						CCDC53_uc010svx.1_Intron|CCDC53_uc010svy.1_Intron|CCDC53_uc010svz.1_Intron	NM_016053	NP_057137			coiled-coil domain containing 53							WASH complex	protein binding				0																		---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104111297	104111297	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104111297delA	uc001tjw.2	+						STAB2_uc009zug.2_Intron	NM_017564	NP_060034			stabilin 2 precursor						angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
C12orf45	121053	broad.mit.edu	37	12	105381818	105381818	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105381818delA	uc001tlb.2	+							NM_152318	NP_689531			hypothetical protein LOC121053												0																		---	---	---	---
RAD9B	144715	broad.mit.edu	37	12	110950776	110950779	+	Intron	DEL	TTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110950776_110950779delTTTT	uc001trf.3	+						RAD9B_uc001trg.3_Intron|RAD9B_uc010sya.1_Intron|RAD9B_uc001tre.3_Intron|RAD9B_uc001trd.3_Intron	NM_152442	NP_689655			RAD9 homolog B						cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2																		---	---	---	---
FBXO21	23014	broad.mit.edu	37	12	117603583	117603583	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117603583delA	uc001twk.2	-						FBXO21_uc001twj.2_Intron|FBXO21_uc009zwq.2_Intron|FBXO21_uc001twl.1_Intron	NM_033624	NP_296373			F-box only protein 21 isoform 1						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	120720659	120720659	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120720659delA								NME2P1 (27 upstream) : SIRT4 (19504 downstream)																																			---	---	---	---
RNF10	9921	broad.mit.edu	37	12	120990203	120990203	+	Intron	DEL	A	-	-	rs112757664		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120990203delA	uc001typ.3	+						RNF10_uc010szk.1_Intron|RNF10_uc001tyq.3_Intron	NM_014868	NP_055683			ring finger protein 10						negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
Unknown	0	broad.mit.edu	37	12	121352168	121352176	+	IGR	DEL	AAAAAAAAA	-	-	rs111940409		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121352168_121352176delAAAAAAAAA								SPPL3 (10017 upstream) : C12orf27 (55465 downstream)																																			---	---	---	---
WDR66	144406	broad.mit.edu	37	12	122362023	122362025	+	Intron	DEL	TGT	-	-	rs57342224	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122362023_122362025delTGT	uc009zxk.2	+							NM_144668	NP_653269			WD repeat domain 66								calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	19801216	19801216	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19801216delT								TUBA3C (45280 upstream) : LOC100101938 (35725 downstream)																																			---	---	---	---
EFHA1	221154	broad.mit.edu	37	13	22088680	22088680	+	Intron	DEL	T	-	-	rs112252216		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:22088680delT	uc001uof.2	-						EFHA1_uc010tct.1_5'Flank	NM_152726	NP_689939			EF-hand domain family, member A1								calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)														---	---	---	---
MTMR6	9107	broad.mit.edu	37	13	25831642	25831642	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25831642delA	uc001uqf.3	-						MTMR6_uc001uqe.1_Intron	NM_004685	NP_004676			myotubularin related protein 6							cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	26809636	26809636	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26809636delT								RNF6 (13128 upstream) : CDK8 (19120 downstream)																																			---	---	---	---
FRY	10129	broad.mit.edu	37	13	32673954	32673954	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32673954delA	uc001utx.2	+						FRY_uc010tdw.1_Intron	NM_023037	NP_075463			furry homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
MTRF1	9617	broad.mit.edu	37	13	41808318	41808318	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41808318delT	uc001uxx.2	-						MTRF1_uc001uxy.2_Intron|MTRF1_uc001uxz.2_Intron|MTRF1_uc010tff.1_Intron|MTRF1_uc001uyc.1_Intron|uc001uxv.1_Intron	NM_004294	NP_004285			mitochondrial translational release factor 1						regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)														---	---	---	---
RB1	5925	broad.mit.edu	37	13	48954160	48954160	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48954160delT	uc001vcb.2	+							NM_000321	NP_000312			retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---	---
KCNRG	283518	broad.mit.edu	37	13	50594228	50594228	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50594228delA	uc001vdu.2	+						DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_Intron	NM_173605	NP_775876			potassium channel regulator isoform 1							voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)														---	---	---	---
INTS6	26512	broad.mit.edu	37	13	51936274	51936274	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51936274delT	uc001vfk.2	-	18					SERPINE3_uc010tgp.1_Intron|INTS6_uc001vfi.2_3'UTR|INTS6_uc001vfj.2_3'UTR|INTS6_uc001vfl.2_3'UTR	NM_012141	NP_036273			integrator complex subunit 6 isoform a						snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	79668173	79668173	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:79668173delA								RNF219 (433473 upstream) : RBM26 (225927 downstream)																																			---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95725337	95725337	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95725337delA	uc001vmd.3	-						ABCC4_uc010afk.2_Intron	NM_005845	NP_005836			ATP-binding cassette, sub-family C, member 4						platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99536156	99536156	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99536156delA	uc001vnt.2	-						DOCK9_uc001vnw.2_Intron|DOCK9_uc001vnv.1_Intron|DOCK9_uc010tir.1_Intron|DOCK9_uc010tis.1_Intron|DOCK9_uc010tit.1_Intron|DOCK9_uc010afu.1_Intron	NM_015296	NP_056111			dedicator of cytokinesis 9 isoform a						blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
CDC16	8881	broad.mit.edu	37	13	115004335	115004335	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115004335delT	uc001vuk.1	+						CDC16_uc010tkm.1_Intron|CDC16_uc001vul.1_Intron|CDC16_uc001vum.1_Intron|CDC16_uc001vun.1_Intron|CDC16_uc001vuo.1_Intron	NM_003903	NP_003894			anaphase-promoting complex, subunit 6						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)															---	---	---	---
Unknown	0	broad.mit.edu	37	14	19408019	19408019	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19408019delA								OR11H12 (29447 upstream) : POTEG (145346 downstream)																																			---	---	---	---
OR6S1	341799	broad.mit.edu	37	14	21109390	21109390	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21109390delC	uc001vxv.1	-	1	461	c.461delG	c.(460-462)GGAfs	p.G154fs		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)														---	---	---	---
RPGRIP1	57096	broad.mit.edu	37	14	21788458	21788458	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21788458delT	uc001wag.2	+						RPGRIP1_uc001wah.2_Intron|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_5'Flank|RPGRIP1_uc001wak.2_5'Flank|RPGRIP1_uc010aim.2_5'Flank|RPGRIP1_uc001wal.2_5'Flank	NM_020366	NP_065099			retinitis pigmentosa GTPase regulator						response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22892202	22892202	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22892202delA	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wds.1_Intron|uc001wdv.3_Intron|uc001wdt.1_Intron					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
G2E3	55632	broad.mit.edu	37	14	31066424	31066424	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31066424delT	uc001wqk.2	+						G2E3_uc010tpe.1_Intron|G2E3_uc010tpf.1_Intron	NM_017769	NP_060239			G2/M-phase specific E3 ubiquitin ligase						apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
SFTA3	253970	broad.mit.edu	37	14	36982246	36982247	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36982246_36982247insT	uc001wtr.2	-						SFTA3_uc001wtq.2_Intron|SFTA3_uc001wts.2_Intron	NM_001101341	NP_001094811			surfactant associated 3												0																		---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39532705	39532705	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39532705delA	uc001wup.1	-						SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Intron|SEC23A_uc010tqc.1_Intron	NM_006364	NP_006355			SEC23-related protein A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
L2HGDH	79944	broad.mit.edu	37	14	50750481	50750481	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50750481delT	uc001wxu.2	-						L2HGDH_uc010tqn.1_Intron|L2HGDH_uc010tqo.1_Intron	NM_024884	NP_079160			L-2-hydroxyglutarate dehydrogenase precursor						2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)																	---	---	---	---
NIN	51199	broad.mit.edu	37	14	51273539	51273539	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51273539delA	uc001wym.2	-						NIN_uc001wyi.2_Intron|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Intron|NIN_uc001wyo.2_Intron|NIN_uc001wyp.1_Intron	NM_182946	NP_891991			ninein isoform 5						centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)							T	PDGFRB	MPD								---	---	---	---
TXNDC16	57544	broad.mit.edu	37	14	52937566	52937566	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52937566delT	uc001wzs.2	-						TXNDC16_uc010tqu.1_Intron|TXNDC16_uc010aoe.2_Intron	NM_020784	NP_065835			thioredoxin domain containing 16 isoform 1						cell redox homeostasis	extracellular region					0	Breast(41;0.0716)																	---	---	---	---
KTN1	3895	broad.mit.edu	37	14	56116727	56116727	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56116727delA	uc001xcb.2	+						KTN1_uc001xce.2_Intron|KTN1_uc001xcc.2_Intron|KTN1_uc001xcd.2_Intron|KTN1_uc010trb.1_Intron|KTN1_uc001xcf.1_Intron|KTN1_uc010aoq.2_Intron	NM_182926	NP_891556			kinectin 1 isoform a						microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7								T	RET	papillary thryoid								---	---	---	---
Unknown	0	broad.mit.edu	37	14	57150085	57150085	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57150085delT								C14orf101 (33855 upstream) : OTX2 (117342 downstream)																																			---	---	---	---
MUDENG	55745	broad.mit.edu	37	14	57752752	57752752	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57752752delA	uc001xcv.2	+						MUDENG_uc010tri.1_Intron|MUDENG_uc010trj.1_Intron	NM_018229	NP_060699			Mu-2 related death-inducing protein						intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1																		---	---	---	---
C14orf135	64430	broad.mit.edu	37	14	60592345	60592345	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60592345delT	uc001xer.3	+						C14orf135_uc001xeq.2_Intron|C14orf135_uc010apm.2_Intron	NM_022495	NP_071940			hepatitis C virus F protein-binding protein 2							integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64427327	64427327	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64427327delT	uc001xgm.2	+						SYNE2_uc001xgk.2_Intron|SYNE2_uc001xgl.2_Intron	NM_015180	NP_055995			spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64681850	64681850	+	Intron	DEL	A	-	-	rs34764844		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64681850delA	uc001xgm.2	+						SYNE2_uc001xgl.2_Intron|SYNE2_uc010apy.2_Intron|SYNE2_uc001xgn.2_Intron|SYNE2_uc001xgo.2_Intron|SYNE2_uc010aqa.2_Intron|SYNE2_uc001xgq.2_Intron|SYNE2_uc001xgr.2_Intron|SYNE2_uc010tsi.1_Intron|SYNE2_uc001xgs.2_Intron|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995			spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
ATP6V1D	51382	broad.mit.edu	37	14	67809927	67809927	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67809927delT	uc001xjf.2	-						ATP6V1D_uc001xje.2_Intron	NM_015994	NP_057078			H(+)-transporting two-sector ATPase						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71455705	71455705	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71455705delT	uc001xmo.2	+						PCNX_uc001xmn.3_Intron|PCNX_uc010are.1_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
YLPM1	56252	broad.mit.edu	37	14	75264231	75264231	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75264231delT	uc001xqj.3	+						YLPM1_uc001xql.3_Intron	NM_019589	NP_062535			YLP motif containing 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)														---	---	---	---
TTLL5	23093	broad.mit.edu	37	14	76352962	76352963	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76352962_76352963insT	uc001xrx.2	+						TTLL5_uc010ask.1_Intron|TTLL5_uc001xrz.2_Intron|TTLL5_uc001xsa.2_Intron	NM_015072	NP_055887			tubulin tyrosine ligase-like family, member 5						protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79434392	79434399	+	Intron	DEL	CCCCCCCC	-	-	rs148023649		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79434392_79434399delCCCCCCCC	uc001xun.2	+						NRXN3_uc001xum.1_Intron|NRXN3_uc010asv.1_Intron	NM_004796	NP_004787			neurexin 3 isoform 1 precursor						axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81025766	81025766	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81025766delA	uc001xux.2	-						C14orf145_uc010asz.1_Intron	NM_152446	NP_689659			hypothetical protein LOC145508							centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81372534	81372534	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81372534delA	uc001xux.2	-						C14orf145_uc001xuz.2_Intron|C14orf145_uc001xva.1_Intron|C14orf145_uc010ata.1_Intron|C14orf145_uc001xuy.1_5'Flank	NM_152446	NP_689659			hypothetical protein LOC145508							centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
PTPN21	11099	broad.mit.edu	37	14	88971527	88971527	+	Intron	DEL	T	-	-	rs80302635		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88971527delT	uc001xwv.3	-						PTPN21_uc010twc.1_Intron|PTPN21_uc010atf.1_Intron	NM_007039	NP_008970			protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4																		---	---	---	---
TTC7B	145567	broad.mit.edu	37	14	91233373	91233373	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:91233373delA	uc001xyp.2	-							NM_001010854	NP_001010854			tetratricopeptide repeat domain 7B								binding			ovary(2)	2		Melanoma(154;0.222)																---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94128847	94128847	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94128847delA	uc001ybv.1	+						KIAA1409_uc001ybs.1_Intron	NM_020818	NP_065869			hypothetical protein LOC57578							integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96777214	96777216	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96777214_96777216delAAA	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96795732	96795732	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96795732delT	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96809412	96809412	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96809412delA	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
CDC42BPB	9578	broad.mit.edu	37	14	103425947	103425947	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103425947delA	uc001ymi.1	-						CDC42BPB_uc001ymj.1_Intron	NM_006035	NP_006026			CDC42-binding protein kinase beta						actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)														---	---	---	---
TUBGCP5	114791	broad.mit.edu	37	15	22841913	22841913	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22841913delA	uc001yur.3	+						TUBGCP5_uc001yuq.2_Intron	NM_052903	NP_443135			tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)														---	---	---	---
SNRPN	6638	broad.mit.edu	37	15	25222784	25222784	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25222784delA	uc001ywp.1	+						SNRPN_uc001ywq.1_Intron|SNRPN_uc001ywr.1_Intron|SNRPN_uc001yws.1_Intron|SNRPN_uc001ywt.1_Intron|SNRPN_uc001ywv.1_Intron|SNRPN_uc001yww.1_Intron|SNRPN_uc001ywx.1_Intron|SNRPN_uc001ywz.1_Intron|PAR-SN_uc001yxa.1_Intron|SNRPN_uc001ywy.1_Intron	NM_022807	NP_073718			small nuclear ribonucleoprotein polypeptide N						RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			ovary(1)	1		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)										Prader-Willi_syndrome				---	---	---	---
GABRG3	2567	broad.mit.edu	37	15	27271888	27271888	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:27271888delT	uc001zbg.1	+						GABRG3_uc001zbf.2_Intron	NM_033223	NP_150092			gamma-aminobutyric acid (GABA) A receptor, gamma						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)														---	---	---	---
SLC12A6	9990	broad.mit.edu	37	15	34544637	34544637	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34544637delA	uc001zhw.2	-						SLC12A6_uc001zhv.2_Intron|SLC12A6_uc001zhx.2_Intron|SLC12A6_uc001zhy.2_Intron|SLC12A6_uc001zhz.2_Intron|SLC12A6_uc001zia.2_Intron|SLC12A6_uc001zib.2_Intron|SLC12A6_uc001zic.2_Intron|SLC12A6_uc010bau.2_Intron|SLC12A6_uc001zid.2_Intron|SLC12A6_uc001zht.2_5'Flank|SLC12A6_uc001zhu.2_Intron	NM_133647	NP_598408			solute carrier family 12, member 6 isoform a						angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)													---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40477243	40477243	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40477243delT	uc001zkx.3	+						BUB1B_uc010ucl.1_Intron	NM_001211	NP_001202			budding uninhibited by benzimidazoles 1 beta						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
BUB1B	701	broad.mit.edu	37	15	40502550	40502550	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40502550delT	uc001zkx.3	+							NM_001211	NP_001202			budding uninhibited by benzimidazoles 1 beta						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)				Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
C15orf57	90416	broad.mit.edu	37	15	40854796	40854796	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40854796delA	uc001zmc.1	-						C15orf57_uc001zly.2_Intron|C15orf57_uc001zma.1_Intron|C15orf57_uc001zmb.1_Intron|C15orf57_uc010bbr.2_Intron	NM_001080792	NP_001074261			coiled-coil domain containing 32 isoform a											ovary(1)	1																		---	---	---	---
EXD1	161829	broad.mit.edu	37	15	41483956	41483956	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41483956delA	uc001znk.2	-						EXD1_uc001znj.2_5'Flank|EXD1_uc010ucv.1_Intron	NM_152596	NP_689809			exonuclease 3'-5' domain containing 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1																		---	---	---	---
EXD1	161829	broad.mit.edu	37	15	41487862	41487863	+	Intron	DEL	AA	-	-	rs33987701		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41487862_41487863delAA	uc001znk.2	-						EXD1_uc010ucv.1_Intron	NM_152596	NP_689809			exonuclease 3'-5' domain containing 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1																		---	---	---	---
PLA2G4F	255189	broad.mit.edu	37	15	42442182	42442182	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42442182delA	uc001zoz.2	-						PLA2G4F_uc001zoy.2_5'Flank|PLA2G4F_uc010bcr.2_Intron|PLA2G4F_uc001zpa.2_Intron|PLA2G4F_uc010bcs.2_Intron	NM_213600	NP_998765			phospholipase A2, group IVF						phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)														---	---	---	---
TMEM62	80021	broad.mit.edu	37	15	43473707	43473707	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43473707delT	uc001zqr.2	+						TMEM62_uc010bda.2_Intron|TMEM62_uc001zqt.2_Intron	NM_024956	NP_079232			transmembrane protein 62							integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	45508226	45508226	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45508226delT								SHF (14853 upstream) : SLC28A2 (36202 downstream)																																			---	---	---	---
SLC28A2	9153	broad.mit.edu	37	15	45561372	45561372	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45561372delA	uc001zva.2	+							NM_004212	NP_004203			solute carrier family 28 (sodium-coupled						nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)														---	---	---	---
WDR72	256764	broad.mit.edu	37	15	53997668	53997668	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53997668delT	uc002acj.2	-						WDR72_uc010bfi.1_Intron	NM_182758	NP_877435			WD repeat domain 72											lung(1)|skin(1)	2				all cancers(107;0.0511)														---	---	---	---
RNF111	54778	broad.mit.edu	37	15	59387292	59387292	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59387292delT	uc002afv.2	+	14					RNF111_uc002afs.2_3'UTR|RNF111_uc002aft.2_3'UTR|RNF111_uc002afu.2_3'UTR|RNF111_uc002afw.2_3'UTR|RNF111_uc002afx.2_3'UTR|RNF111_uc002afy.2_3'UTR	NM_017610	NP_060080			ring finger protein 111						multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	59817572	59817572	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59817572delT								FAM81A (1821 upstream) : GCNT3 (86410 downstream)																																			---	---	---	---
TLN2	83660	broad.mit.edu	37	15	63014438	63014438	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63014438delT	uc002alb.3	+							NM_015059	NP_055874			talin 2						cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11																		---	---	---	---
DPP8	54878	broad.mit.edu	37	15	65756032	65756032	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65756032delA	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhi.2_Intron|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118			dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1																		---	---	---	---
DPP8	54878	broad.mit.edu	37	15	65772467	65772467	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65772467delA	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118			dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65989151	65989151	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65989151delT	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
LCTL	197021	broad.mit.edu	37	15	66845120	66845120	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66845120delT	uc002aqc.2	-						LCTL_uc002aqd.3_Intron|LCTL_uc010bhw.2_Intron	NM_207338	NP_997221			lactase-like precursor						carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2																		---	---	---	---
PIAS1	8554	broad.mit.edu	37	15	68475931	68475931	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68475931delT	uc002aqz.2	+						PIAS1_uc002ara.2_Intron	NM_016166	NP_057250			protein inhibitor of activated STAT, 1						androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
TLE3	7090	broad.mit.edu	37	15	70342715	70342715	+	Intron	DEL	G	-	-	rs3215108		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:70342715delG	uc002asm.2	-						TLE3_uc002ask.2_Intron|TLE3_uc002asl.2_Intron|TLE3_uc010ukd.1_Intron|TLE3_uc010bik.1_Intron|TLE3_uc010bil.1_Intron|TLE3_uc002asn.2_Intron|TLE3_uc002asp.2_Intron|TLE3_uc002aso.2_Intron	NM_005078	NP_005069			transducin-like enhancer protein 3 isoform a						organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2																		---	---	---	---
THSD4	79875	broad.mit.edu	37	15	72041049	72041049	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72041049delA	uc002atb.1	+						THSD4_uc002ate.2_Intron	NM_024817	NP_079093			thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72208543	72208543	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72208543delT	uc002atl.3	-						MYO9A_uc010biq.2_Intron|MYO9A_uc002atn.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
NEO1	4756	broad.mit.edu	37	15	73558929	73558929	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73558929delT	uc002avm.3	+						NEO1_uc010ukx.1_Intron|NEO1_uc010uky.1_Intron|NEO1_uc010ukz.1_Intron|NEO1_uc002avn.3_Intron	NM_002499	NP_002490			neogenin homolog 1 precursor						axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1																		---	---	---	---
CPLX3	594855	broad.mit.edu	37	15	75122349	75122350	+	Intron	INS	-	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75122349_75122350insG	uc002ayu.1	+							NM_001030005	NP_001025176			complexin 3 precursor							cell junction|synapse	syntaxin binding				0																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75676395	75676396	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75676395_75676396delTT	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75706706	75706706	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75706706delA	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
ADAMTS7	11173	broad.mit.edu	37	15	79066865	79066865	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79066865delG	uc002bej.3	-						ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Intron	NM_014272	NP_055087			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
ZFAND6	54469	broad.mit.edu	37	15	80430027	80430027	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:80430027delT	uc002bfe.1	+	7					ZFAND6_uc002bff.1_3'UTR|ZFAND6_uc002bfg.1_3'UTR|ZFAND6_uc002bfh.1_3'UTR|ZFAND6_uc002bfi.1_3'UTR	NM_019006	NP_061879			zinc finger, AN1-type domain 6								DNA binding|zinc ion binding				0																		---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84561733	84561733	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84561733delA	uc002bjz.3	+						ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
PLIN1	5346	broad.mit.edu	37	15	90220479	90220479	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90220479delT	uc010upx.1	-						PLIN1_uc002boh.2_Intron	NM_001145311	NP_001138783			perilipin 1						triglyceride catabolic process	lipid particle	lipid binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
AP3S2	10239	broad.mit.edu	37	15	90414601	90414601	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90414601delA	uc002boq.3	-						AP3S2_uc002bos.3_Intron|AP3S2_uc010bns.2_Intron|AP3S2_uc002bor.3_Intron|AP3S2_uc010bnt.2_Intron	NM_005829	NP_005820			adaptor-related protein complex 3, sigma 2						intracellular protein transport|vesicle-mediated transport	cytoplasmic vesicle membrane|Golgi apparatus|membrane coat	protein transporter activity				0	Lung NSC(78;0.0181)|all_lung(78;0.0384)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.223)															---	---	---	---
SLCO3A1	28232	broad.mit.edu	37	15	92694020	92694020	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:92694020delA	uc002bqx.2	+						SLCO3A1_uc002bqy.2_Intron|SLCO3A1_uc010boc.1_Intron|SLCO3A1_uc002bqz.1_Intron	NM_013272	NP_037404			solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)															---	---	---	---
CHD2	1106	broad.mit.edu	37	15	93467483	93467483	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:93467483delT	uc002bsp.2	+						CHD2_uc002bsm.1_Intron|CHD2_uc002bsn.2_Intron|CHD2_uc002bso.1_Intron|CHD2_uc010urb.1_Intron	NM_001271	NP_001262			chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)															---	---	---	---
CHD2	1106	broad.mit.edu	37	15	93557783	93557783	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:93557783delT	uc002bsp.2	+						CHD2_uc002bso.1_Intron	NM_001271	NP_001262			chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)															---	---	---	---
IGFALS	3483	broad.mit.edu	37	16	1842147	1842147	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1842147delG	uc002cmy.2	-	2	353	c.272delC	c.(271-273)CCGfs	p.P91fs	IGFALS_uc010uvn.1_Frame_Shift_Del_p.P129fs|IGFALS_uc010uvo.1_5'UTR	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	91	LRR 1.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0																		---	---	---	---
HAGH	3029	broad.mit.edu	37	16	1869837	1869837	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1869837delC	uc002cna.2	-						HAGH_uc002cmz.2_Intron|HAGH_uc010uvp.1_Intron|HAGH_uc002cnb.1_Intron|HAGH_uc010bry.1_Intron	NM_005326	NP_005317			hydroxyacylglutathione hydrolase isoform 1						glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)													---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2806346	2806346	+	5'UTR	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2806346delC	uc002crk.2	+	2					SRRM2_uc002crj.1_Intron|SRRM2_uc002crl.1_5'UTR|SRRM2_uc010bsu.1_Intron	NM_016333	NP_057417			splicing coactivator subunit SRm300							Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
PKMYT1	9088	broad.mit.edu	37	16	3024526	3024526	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3024526delC	uc002csn.2	-						PKMYT1_uc010uwn.1_Intron|PKMYT1_uc002csm.2_Intron|PKMYT1_uc002cso.2_Intron|PKMYT1_uc002csp.2_Intron|PKMYT1_uc002csq.2_Intron|PKMYT1_uc010bsy.1_Intron	NM_004203	NP_004194			protein kinase Myt1 isoform 1						G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1																		---	---	---	---
PKMYT1	9088	broad.mit.edu	37	16	3026876	3026876	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3026876delG	uc002csn.2	-	3	610	c.167delC	c.(166-168)CCTfs	p.P56fs	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Frame_Shift_Del_p.P56fs|PKMYT1_uc002cso.2_Intron|PKMYT1_uc002csp.2_Frame_Shift_Del_p.P47fs|PKMYT1_uc002csq.2_Frame_Shift_Del_p.P47fs|PKMYT1_uc010bsy.1_Frame_Shift_Del_p.P47fs	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	56	Pro-rich.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1																		---	---	---	---
C16orf90	646174	broad.mit.edu	37	16	3546141	3546141	+	5'Flank	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3546141delA	uc002cvi.2	-							NM_001080524	NP_001073993			hypothetical protein LOC646174												0																		---	---	---	---
CREBBP	1387	broad.mit.edu	37	16	3820360	3820360	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3820360delA	uc002cvv.2	-						CREBBP_uc002cvw.2_Intron	NM_004380	NP_004371			CREB binding protein isoform a						cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)				T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				---	---	---	---
TFAP4	7023	broad.mit.edu	37	16	4309949	4309949	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4309949delC	uc010uxg.1	-							NM_003223	NP_003214			transcription factor AP-4 (activating enhancer						DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1																		---	---	---	---
PPL	5493	broad.mit.edu	37	16	4938714	4938714	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4938714delT	uc002cyd.1	-							NM_002705	NP_002696			periplakin						keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	9250813	9250813	+	IGR	DEL	T	-	-	rs115093816	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:9250813delT								C16orf72 (37268 upstream) : GRIN2A (596454 downstream)																																			---	---	---	---
CLEC16A	23274	broad.mit.edu	37	16	11066725	11066726	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11066725_11066726delTT	uc002dao.2	+						CLEC16A_uc002dan.3_Intron	NM_015226	NP_056041			C-type lectin domain family 16, member A											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CLEC16A	23274	broad.mit.edu	37	16	11154578	11154578	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11154578delT	uc002dao.2	+						CLEC16A_uc002dan.3_Intron	NM_015226	NP_056041			C-type lectin domain family 16, member A											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PARN	5073	broad.mit.edu	37	16	14700252	14700252	+	Intron	DEL	G	-	-	rs62037478		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14700252delG	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
PARN	5073	broad.mit.edu	37	16	14704343	14704347	+	Intron	DEL	AAAAT	-	-	rs35054309		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14704343_14704347delAAAAT	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
MYH11	4629	broad.mit.edu	37	16	15870226	15870226	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15870226delA	uc002ddy.2	-						MYH11_uc002ddv.2_Intron|MYH11_uc002ddw.2_Intron|MYH11_uc002ddx.2_Intron|MYH11_uc010bvg.2_Intron|MYH11_uc002dea.1_Intron	NM_002474	NP_002465			smooth muscle myosin heavy chain 11 isoform						axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15								T	CBFB	AML								---	---	---	---
ARL6IP1	23204	broad.mit.edu	37	16	18806775	18806775	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18806775delA	uc002dfl.1	-						ARL6IP1_uc010van.1_Intron|ARL6IP1_uc010bvz.1_Intron	NM_015161	NP_055976			ADP-ribosylation factor-like 6 interacting							integral to membrane	protein binding				0																		---	---	---	---
TMC5	79838	broad.mit.edu	37	16	19455699	19455699	+	Intron	DEL	G	-	-	rs4782248	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19455699delG	uc002dgc.3	+						TMC5_uc010vaq.1_Intron|TMC5_uc002dgb.3_Intron|TMC5_uc010var.1_Intron	NM_001105248	NP_001098718			transmembrane channel-like 5 isoform a							integral to membrane				skin(1)	1																		---	---	---	---
METTL9	51108	broad.mit.edu	37	16	21664118	21664118	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21664118delT	uc002dje.2	+						uc002diq.3_Intron|METTL9_uc002djf.2_Intron|IGSF6_uc002djg.1_5'Flank|IGSF6_uc010vbi.1_5'Flank	NM_016025	NP_057109			methyltransferase like 9 isoform 1											ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)														---	---	---	---
COG7	91949	broad.mit.edu	37	16	23445812	23445812	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23445812delC	uc002dlo.2	-							NM_153603	NP_705831			component of oligomeric golgi complex 7						intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)												OREG0023684	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CLN3	1201	broad.mit.edu	37	16	28494128	28494128	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28494128delA	uc002dpo.2	-						uc010vct.1_Intron|CLN3_uc002dpl.2_Intron|CLN3_uc010vcu.1_Intron|CLN3_uc002dpn.2_Intron|CLN3_uc002dpm.2_Intron|CLN3_uc010vcv.1_Intron|CLN3_uc010byd.2_Intron|CLN3_uc002dpp.2_Intron|CLN3_uc002dpt.1_Intron|CLN3_uc002dpq.1_Intron|CLN3_uc010bye.1_Intron|CLN3_uc002dpr.1_Intron|CLN3_uc010byf.1_Intron|CLN3_uc002dps.1_Intron|CLN3_uc002dpu.1_Intron|CLN3_uc002dpw.1_Intron|CLN3_uc010vcw.1_Intron|CLN3_uc002dqa.2_Intron|CLN3_uc010vcx.1_Intron|CLN3_uc002dpx.1_Intron|CLN3_uc002dpy.1_Intron	NM_000086	NP_000077			ceroid-lipofuscinosis, neuronal 3						amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	29110406	29110406	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29110406delT	uc010vct.1	-						RRN3P2_uc002dsf.3_Intron|RRN3P2_uc002dsg.3_Intron|RRN3P2_uc010vdn.1_Intron					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																														---	---	---	---
SEZ6L2	26470	broad.mit.edu	37	16	29891491	29891492	+	Intron	DEL	TT	-	-	rs71373211		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29891491_29891492delTT	uc002duq.3	-						uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Intron|SEZ6L2_uc002dur.3_Intron|SEZ6L2_uc002dus.3_Intron|SEZ6L2_uc010vec.1_Intron|SEZ6L2_uc010ved.1_Intron	NM_201575	NP_963869			seizure related 6 homolog (mouse)-like 2 isoform							endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
INO80E	283899	broad.mit.edu	37	16	30007665	30007665	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30007665delA	uc002dvg.1	+	1	135	c.34delA	c.(34-36)AAAfs	p.K12fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_Frame_Shift_Del_p.K12fs|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Frame_Shift_Del_p.K12fs|HIRIP3_uc002dve.2_5'Flank|HIRIP3_uc002dvf.2_5'Flank	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	12	Potential.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	33942128	33942129	+	IGR	INS	-	T	T	rs76660512	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33942128_33942129insT								None (None upstream) : MIR1826 (23379 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	34338936	34338936	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34338936delA								MIR1826 (373344 upstream) : UBE2MP1 (64866 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	16	34654646	34654646	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34654646delA								LOC283914 (28562 upstream) : LOC146481 (57139 downstream)																																			---	---	---	---
LONP2	83752	broad.mit.edu	37	16	48311580	48311580	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48311580delT	uc002efi.1	+						LONP2_uc010vgm.1_Intron|LONP2_uc002efj.1_Intron	NM_031490	NP_113678			peroxisomal LON protease-like						misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0																		---	---	---	---
LONP2	83752	broad.mit.edu	37	16	48368805	48368805	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48368805delT	uc002efi.1	+						LONP2_uc010vgm.1_Intron|LONP2_uc002efj.1_Intron	NM_031490	NP_113678			peroxisomal LON protease-like						misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0																		---	---	---	---
LONP2	83752	broad.mit.edu	37	16	48381942	48381942	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48381942delT	uc002efi.1	+						LONP2_uc002efj.1_Intron	NM_031490	NP_113678			peroxisomal LON protease-like						misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0																		---	---	---	---
SIAH1	6477	broad.mit.edu	37	16	48396053	48396053	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48396053delA	uc002efo.1	-	2	404	c.287delT	c.(286-288)TTCfs	p.F96fs	uc002efk.1_RNA|SIAH1_uc002efl.2_RNA|SIAH1_uc002efn.1_Frame_Shift_Del_p.F127fs	NM_003031	NP_003022	Q8IUQ4	SIAH1_HUMAN	seven in absentia homolog 1 isoform a	96	SIAH-type.|SBD.				axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)																---	---	---	---
Unknown	0	broad.mit.edu	37	16	53403273	53403273	+	RNA	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53403273delA	uc002ehh.2	-	2		c.1186delT								Homo sapiens mRNA; cDNA DKFZp313P036 (from clone DKFZp313P036).																														---	---	---	---
CNGB1	1258	broad.mit.edu	37	16	57994547	57994547	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57994547delG	uc002emt.2	-						CNGB1_uc010cdh.2_Intron|CNGB1_uc002emu.2_Intron	NM_001297	NP_001288			cyclic nucleotide gated channel beta 1 isoform						sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4																		---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58622855	58622855	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58622855delA	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc002enx.2_Intron|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
NAE1	8883	broad.mit.edu	37	16	66839541	66839543	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66839541_66839543delAAA	uc002eqf.2	-						NAE1_uc002eqe.2_Intron|NAE1_uc002eqg.2_Intron|NAE1_uc010cdv.2_Intron	NM_003905	NP_003896			NEDD8 activating enzyme E1 subunit 1 isoform a						apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)													---	---	---	---
SMPD3	55512	broad.mit.edu	37	16	68404695	68404695	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68404695delC	uc002ewa.2	-						SMPD3_uc010cfe.2_Intron|SMPD3_uc010vlh.1_Intron	NM_018667	NP_061137			neutral sphingomyelin phosphodiesterase 3						cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)													---	---	---	---
TERF2	7014	broad.mit.edu	37	16	69419639	69419639	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69419639delC	uc002exd.2	-	1	235	c.110delG	c.(109-111)GGCfs	p.G37fs	TERF2_uc002exe.2_Frame_Shift_Del_p.G37fs	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	37					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)																---	---	---	---
NFAT5	10725	broad.mit.edu	37	16	69710992	69710992	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69710992delT	uc002exm.1	+						NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Intron|NFAT5_uc002exj.1_Intron|NFAT5_uc002exk.1_Intron|NFAT5_uc002exl.1_Intron|NFAT5_uc002exn.1_Intron	NM_006599	NP_006590			nuclear factor of activated T-cells 5 isoform c						excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
NOB1	28987	broad.mit.edu	37	16	69782073	69782073	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69782073delA	uc002exs.2	-							NM_014062	NP_054781			nin one binding protein							nucleus	metal ion binding|protein binding				0																		---	---	---	---
CLEC18C	283971	broad.mit.edu	37	16	70030143	70030143	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70030143delA	uc002exy.2	+						PDXDC2_uc002eyb.2_Intron|PDXDC2_uc002eyc.2_Intron	NM_182619	NP_872425			secretory protein LOC348174 precursor							extracellular region	sugar binding				0																		---	---	---	---
CLEC18C	283971	broad.mit.edu	37	16	70045882	70045882	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70045882delA	uc002exy.2	+						PDXDC2_uc002eyb.2_Intron|PDXDC2_uc002eyc.2_Intron	NM_182619	NP_872425			secretory protein LOC348174 precursor							extracellular region	sugar binding				0																		---	---	---	---
AARS	16	broad.mit.edu	37	16	70303887	70303887	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70303887delT	uc002eyn.1	-						AARS_uc010vlu.1_Intron	NM_001605	NP_001596			alanyl-tRNA synthetase						alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)													---	---	---	---
DDX19A	55308	broad.mit.edu	37	16	70351678	70351678	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70351678delA	uc002eys.2	+						DDX19B_uc010vly.1_Intron|DDX19B_uc010vlv.1_Intron|DDX19B_uc010vlw.1_Intron|DDX19B_uc002eyo.2_Intron|DDX19B_uc002eyp.2_Intron|DDX19B_uc002eyq.2_Intron|DDX19B_uc002eyr.2_Intron|DDX19B_uc010vlx.1_Intron|uc002eyt.2_Intron	NM_007242	NP_009173			DEAD (Asp-Glu-Ala-As) box polypeptide 19 isoform						mRNA transport|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding				0		Ovarian(137;0.221)																---	---	---	---
VAC14	55697	broad.mit.edu	37	16	70765775	70765775	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70765775delA	uc002ezm.2	-						VAC14_uc010cfw.2_Intron|VAC14_uc002ezn.2_Intron|VAC14_uc002ezl.2_5'Flank|VAC14_uc010cfx.1_Intron	NM_018052	NP_060522			Vac14 homolog						interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)																---	---	---	---
KIAA0174	9798	broad.mit.edu	37	16	71949359	71949359	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71949359delT	uc002fbj.1	+						KIAA0174_uc010cgh.1_Intron|KIAA0174_uc002fbk.1_Intron|KIAA0174_uc002fbm.1_Intron|KIAA0174_uc002fbl.1_Intron|KIAA0174_uc002fbn.1_Intron|KIAA0174_uc010cgi.1_5'Flank|KIAA0174_uc010cgj.1_5'Flank|KIAA0174_uc010vmk.1_Intron					SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;						cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1																		---	---	---	---
PMFBP1	83449	broad.mit.edu	37	16	72163921	72163924	+	Intron	DEL	TTTT	-	-	rs67023960		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72163921_72163924delTTTT	uc002fcc.3	-						PMFBP1_uc002fcd.2_Intron|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Intron|PMFBP1_uc010cgo.1_5'Flank	NM_031293	NP_112583			polyamine modulated factor 1 binding protein 1											ovary(2)	2		Ovarian(137;0.179)																---	---	---	---
BCAR1	9564	broad.mit.edu	37	16	75269317	75269318	+	Frame_Shift_Ins	INS	-	G	G	rs3206884		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75269317_75269318insG	uc002fdv.2	-	5	1602_1603	c.1479_1480insC	c.(1477-1482)CCCTCTfs	p.P493fs	BCAR1_uc002fdt.2_5'UTR|BCAR1_uc002fdu.2_Frame_Shift_Ins_p.P283fs|BCAR1_uc010cgu.2_Frame_Shift_Ins_p.P482fs|BCAR1_uc010vna.1_Frame_Shift_Ins_p.P491fs|BCAR1_uc010vnb.1_Frame_Shift_Ins_p.P539fs|BCAR1_uc002fdw.2_Frame_Shift_Ins_p.P493fs|BCAR1_uc010vnc.1_Frame_Shift_Ins_p.P345fs|BCAR1_uc010vnd.1_Frame_Shift_Ins_p.P511fs|BCAR1_uc002fdx.2_Frame_Shift_Ins_p.P511fs	NM_014567	NP_055382	P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	493_494	Ser-rich.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			central_nervous_system(5)|breast(2)|prostate(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.169)														---	---	---	---
CFDP1	10428	broad.mit.edu	37	16	75327732	75327732	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75327732delA	uc002fdy.2	-	7					CFDP1_uc002fdz.2_3'UTR	NM_006324	NP_006315			craniofacial development protein 1						multicellular organismal development					upper_aerodigestive_tract(1)	1																		---	---	---	---
MON1B	22879	broad.mit.edu	37	16	77229083	77229084	+	Intron	INS	-	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77229083_77229084insG	uc002fez.2	+						MON1B_uc010vnf.1_Intron|MON1B_uc010vng.1_Intron|MON1B_uc002ffa.2_Intron	NM_014940	NP_055755			MON1 homolog B								protein binding				0																		---	---	---	---
ADAMTS18	170692	broad.mit.edu	37	16	77359576	77359579	+	Intron	DEL	AAAA	-	-	rs36036462		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77359576_77359579delAAAA	uc002ffc.3	-						ADAMTS18_uc010chc.1_Intron|ADAMTS18_uc002ffe.1_Intron	NM_199355	NP_955387			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18																		---	---	---	---
VAT1L	57687	broad.mit.edu	37	16	77850683	77850683	+	Intron	DEL	A	-	-	rs71884745		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:77850683delA	uc002ffg.1	+							NM_020927	NP_065978			vesicle amine transport protein 1 homolog (T.								oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
KLHL36	79786	broad.mit.edu	37	16	84690290	84690290	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84690290delA	uc002fig.2	+						KLHL36_uc010chl.2_Intron	NM_024731	NP_079007			kelch-like 36											skin(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	85848160	85848160	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85848160delT								COX4I1 (7555 upstream) : IRF8 (84614 downstream)																																			---	---	---	---
MTHFSD	64779	broad.mit.edu	37	16	86582296	86582296	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:86582296delT	uc002fjn.2	-						MTHFSD_uc010voo.1_Intron|MTHFSD_uc002fjo.2_Intron|MTHFSD_uc002fjm.2_Intron|MTHFSD_uc010vop.1_Intron|MTHFSD_uc010voq.1_Intron|MTHFSD_uc010vor.1_Intron|MTHFSD_uc002fjp.2_Intron	NM_001159377	NP_001152849			methenyltetrahydrofolate synthetase domain						folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0																		---	---	---	---
RPH3AL	9501	broad.mit.edu	37	17	69318	69322	+	Intron	DEL	TTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:69318_69322delTTTTT	uc002frd.1	-						RPH3AL_uc010vpy.1_Intron|RPH3AL_uc002fre.1_Intron|RPH3AL_uc002frf.1_Intron|RPH3AL_uc010cjl.1_Intron	NM_006987	NP_008918			rabphilin 3A-like (without C2 domains)						exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)														---	---	---	---
GLOD4	51031	broad.mit.edu	37	17	673936	673937	+	Intron	DEL	TT	-	-	rs72295826		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:673936_673937delTT	uc002frv.2	-						GLOD4_uc002frt.2_Intron|GLOD4_uc002fru.2_Intron|GLOD4_uc010vqc.1_Intron	NM_016080	NP_057164			glyoxalase domain containing 4							mitochondrion					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.022)														---	---	---	---
METT10D	79066	broad.mit.edu	37	17	2405282	2405282	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2405282delT	uc002fut.2	-						METT10D_uc002fuu.3_Intron|METT10D_uc010cka.2_Intron|METT10D_uc002fuv.2_Intron|METT10D_uc010vqx.1_Intron|METT10D_uc010vqy.1_Intron	NM_024086	NP_076991			methyltransferase 10 domain containing								methyltransferase activity				0																		---	---	---	---
PAFAH1B1	5048	broad.mit.edu	37	17	2573288	2573288	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2573288delA	uc002fuw.3	+						PAFAH1B1_uc010ckb.1_Intron|PAFAH1B1_uc010vqz.1_5'Flank	NM_000430	NP_000421			platelet-activating factor acetylhydrolase,						acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1																		---	---	---	---
MINK1	50488	broad.mit.edu	37	17	4797719	4797719	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4797719delG	uc010vsl.1	+						MINK1_uc010vsk.1_Intron|MINK1_uc010vsm.1_Intron|MINK1_uc010vsn.1_Intron|MINK1_uc010vso.1_Intron|MINK1_uc010vsp.1_Intron	NM_153827	NP_722549			misshapen-like kinase 1 isoform 3						JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6																		---	---	---	---
USP6	9098	broad.mit.edu	37	17	5047792	5047792	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5047792delT	uc002gau.1	+						USP6_uc002gav.1_Intron|USP6_uc010ckz.1_Intron	NM_004505	NP_004496			ubiquitin specific protease 6						protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5								T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								---	---	---	---
CHD3	1107	broad.mit.edu	37	17	7805739	7805739	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7805739delA	uc002gje.2	+						CHD3_uc002gjd.2_Intron|CHD3_uc002gjf.2_Intron|CHD3_uc002gjh.2_5'Flank	NM_001005273	NP_001005273			chromodomain helicase DNA binding protein 3						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)																---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10216089	10216089	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10216089delT	uc002gmk.1	-							NM_003802	NP_003793			myosin, heavy polypeptide 13, skeletal muscle						muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	14851004	14851004	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:14851004delT								HS3ST3B1 (601512 upstream) : PMP22 (282093 downstream)																																			---	---	---	---
PEMT	10400	broad.mit.edu	37	17	17488671	17488671	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17488671delA	uc002grl.2	-						PEMT_uc002grk.2_5'Flank|PEMT_uc010vwx.1_Intron	NM_148172	NP_680477			phosphatidylethanolamine N-methyltransferase						cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity				0				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)														---	---	---	---
TAOK1	57551	broad.mit.edu	37	17	27816527	27816527	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27816527delA	uc002hdz.1	+						TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Intron|TAOK1_uc002heb.1_Intron	NM_020791	NP_065842			TAO kinase 1						mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)															---	---	---	---
TBC1D29	26083	broad.mit.edu	37	17	28885450	28885451	+	5'Flank	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28885450_28885451insT	uc002hfh.2	+						uc002hfg.1_5'Flank|TBC1D29_uc002hfi.2_5'Flank	NM_015594	NP_056409			TBC1 domain family, member 29							intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)																---	---	---	---
SUZ12P	440423	broad.mit.edu	37	17	29086616	29086616	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29086616delA	uc002hfn.1	+						SUZ12P_uc002hfo.2_Intron|SUZ12P_uc002hfq.2_Intron					Homo sapiens cDNA clone IMAGE:5299523, containing frame-shift errors.												0																		---	---	---	---
RHOT1	55288	broad.mit.edu	37	17	30531105	30531105	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30531105delT	uc002hgz.2	+						RHOT1_uc002hgw.2_Intron|RHOT1_uc002hgy.2_Intron|RHOT1_uc002hha.2_Intron|RHOT1_uc010csv.2_Intron|RHOT1_uc002hgx.2_Intron|RHOT1_uc010wby.1_Intron|RHOT1_uc002hhb.2_Intron|RHOT1_uc002hgv.2_Intron	NM_018307	NP_060777			ras homolog gene family, member T1 isoform 3						apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
MYO1D	4642	broad.mit.edu	37	17	31103177	31103177	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:31103177delA	uc002hho.1	-						MYO1D_uc002hhp.1_Intron|MYO1D_uc010wcb.1_Intron	NM_015194	NP_056009			myosin ID							myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	33332963	33332963	+	5'Flank	DEL	T	-	-	rs71364691		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33332963delT	uc002hil.2	+											Homo sapiens cDNA FLJ34173 fis, clone FCBBF3015809.																														---	---	---	---
TAF15	8148	broad.mit.edu	37	17	34161084	34161085	+	Intron	DEL	TA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34161084_34161085delTA	uc002hkd.2	+						TAF15_uc010ctw.1_Intron|TAF15_uc002hkc.2_Intron	NM_139215	NP_631961			TBP-associated factor 15 isoform 1						positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)				T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL								---	---	---	---
GGNBP2	79893	broad.mit.edu	37	17	34923771	34923772	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34923771_34923772delTT	uc002hnb.2	+						GGNBP2_uc002hna.2_Intron	NM_024835	NP_079111			zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)														---	---	---	---
AATF	26574	broad.mit.edu	37	17	35346372	35346372	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35346372delT	uc002hni.2	+						AATF_uc002hnj.2_Intron	NM_012138	NP_036270			apoptosis antagonizing transcription factor						anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity				0		Breast(25;0.00607)																---	---	---	---
ACACA	31	broad.mit.edu	37	17	35642051	35642051	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35642051delA	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuz.2_Intron|ACACA_uc002hnq.2_Intron|ACACA_uc002hnp.1_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
MED1	5469	broad.mit.edu	37	17	37597110	37597110	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37597110delA	uc002hrv.3	-						MED1_uc010wee.1_Intron|MED1_uc002hru.2_Intron	NM_004774	NP_004765			mediator complex subunit 1						androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)											HNSCC(31;0.082)			---	---	---	---
TOP2A	7153	broad.mit.edu	37	17	38562532	38562532	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38562532delT	uc002huq.2	-							NM_001067	NP_001058			DNA topoisomerase II, alpha isozyme						apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)													---	---	---	---
KLHL10	317719	broad.mit.edu	37	17	39994521	39994523	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39994521_39994523delTTT	uc010cxr.2	+						NT5C3L_uc002hyb.3_5'Flank|NT5C3L_uc002hyc.3_5'Flank|NT5C3L_uc002hyd.3_5'Flank|NT5C3L_uc002hxy.3_5'Flank|NT5C3L_uc002hxz.3_5'Flank|NT5C3L_uc002hya.3_5'Flank|KLHL10_uc010wfv.1_Intron|KLHL10_uc010wfw.1_Intron	NM_152467	NP_689680			kelch-like 10							cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	40800012	40800012	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40800012delA								TUBG1 (32758 upstream) : TUBG2 (11254 downstream)																																			---	---	---	---
DBF4B	80174	broad.mit.edu	37	17	42818501	42818501	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42818501delA	uc002ihf.2	+						DBF4B_uc010wjb.1_Intron|DBF4B_uc002ihe.2_Intron|DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696			DBF4 homolog B isoform 1						cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)																---	---	---	---
B4GALNT2	124872	broad.mit.edu	37	17	47218386	47218387	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47218386_47218387delTT	uc002ion.2	+						B4GALNT2_uc010wlt.1_Intron|B4GALNT2_uc010wlu.1_Intron	NM_153446	NP_703147			beta-1,4-N-acetyl-galactosaminyl transferase 2						lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)															---	---	---	---
COL1A1	1277	broad.mit.edu	37	17	48269273	48269273	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48269273delA	uc002iqm.2	-							NM_000088	NP_000079			alpha 1 type I collagen preproprotein						axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						---	---	---	---
SPAG9	9043	broad.mit.edu	37	17	49073715	49073715	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49073715delC	uc002itc.2	-						SPAG9_uc002itb.2_Intron|SPAG9_uc002itd.2_Intron|SPAG9_uc002itf.2_Intron|SPAG9_uc002ita.2_Intron|SPAG9_uc002ite.2_Intron	NM_001130528	NP_001124000			sperm associated antigen 9 isoform 1						positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)															---	---	---	---
DHX40	79665	broad.mit.edu	37	17	57665581	57665591	+	Intron	DEL	AAAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57665581_57665591delAAAAAAAAAAA	uc002ixn.1	+						DHX40_uc010woe.1_Intron|DHX40_uc010wof.1_Intron	NM_024612	NP_078888			DEAH (Asp-Glu-Ala-His) box polypeptide 40								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)																	---	---	---	---
INTS2	57508	broad.mit.edu	37	17	59974795	59974796	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59974795_59974796delTT	uc002izn.2	-						INTS2_uc002izm.2_Intron	NM_020748	NP_065799			integrator complex subunit 2						snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
LRRC37A3	374819	broad.mit.edu	37	17	62864851	62864852	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62864851_62864852delTT	uc002jey.2	-						LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron|LRRC37A3_uc010dek.1_Intron	NM_199340	NP_955372			leucine rich repeat containing 37, member A3							integral to membrane					0																		---	---	---	---
AXIN2	8313	broad.mit.edu	37	17	63532780	63532780	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63532780delA	uc002jfi.2	-						AXIN2_uc002jfh.2_Intron	NM_004655	NP_004646			axin 2						cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2														Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64179497	64179497	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64179497delA	uc002jfl.2	-						CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
ABCA8	10351	broad.mit.edu	37	17	66872446	66872446	+	Intron	DEL	T	-	-	rs4148026		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66872446delT	uc002jhp.2	-						ABCA8_uc002jhq.2_Intron|ABCA8_uc010wqq.1_Intron	NM_007168	NP_009099			ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)																	---	---	---	---
COG1	9382	broad.mit.edu	37	17	71201466	71201466	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71201466delT	uc002jjg.2	+						COG1_uc002jjh.2_Intron|COG1_uc002jjf.1_Intron	NM_018714	NP_061184			component of oligomeric golgi complex 1						Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)															---	---	---	---
TTYH2	94015	broad.mit.edu	37	17	72233212	72233213	+	Intron	INS	-	T	T	rs112294492		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72233212_72233213insT	uc002jkc.2	+						TTYH2_uc010wqw.1_Intron	NM_032646	NP_116035			tweety 2 isoform 1							chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
ACOX1	51	broad.mit.edu	37	17	73944640	73944640	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73944640delT	uc002jqf.2	-						ACOX1_uc010wsq.1_Intron|ACOX1_uc002jqe.2_Intron|ACOX1_uc010wsr.1_Intron	NM_007292	NP_009223			acyl-Coenzyme A oxidase 1 isoform b						fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1																		---	---	---	---
TIMP2	7077	broad.mit.edu	37	17	76866754	76866754	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76866754delT	uc002jwf.2	-						TIMP2_uc002jwe.2_Intron|TIMP2_uc010wty.1_Intron	NM_003255	NP_003246			TIMP metallopeptidase inhibitor 2 precursor								metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)															---	---	---	---
TIMP2	7077	broad.mit.edu	37	17	76866888	76866888	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76866888delC	uc002jwf.2	-						TIMP2_uc002jwe.2_Intron|TIMP2_uc010wty.1_Intron	NM_003255	NP_003246			TIMP metallopeptidase inhibitor 2 precursor								metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	78262707	78262708	+	Intron	DEL	GA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78262707_78262708delGA	uc002jyf.2	+						uc002jyg.1_Intron	NM_020954	NP_066005			hypothetical protein LOC57714																														---	---	---	---
SLC38A10	124565	broad.mit.edu	37	17	79249532	79249532	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79249532delA	uc002jzz.1	-						SLC38A10_uc002jzy.1_Intron|SLC38A10_uc002kab.2_Intron	NM_001037984	NP_001033073			solute carrier family 38, member 10 isoform a						amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)															---	---	---	---
BAHCC1	57597	broad.mit.edu	37	17	79429649	79429654	+	Intron	DEL	CACACT	-	-	rs117786821	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79429649_79429654delCACACT	uc002kaf.2	+							NM_001080519	NP_001073988			BAH domain and coiled-coil containing 1								DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)															---	---	---	---
GNAL	2774	broad.mit.edu	37	18	11862560	11862560	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11862560delT	uc010dkz.2	+						GNAL_uc002kqc.2_Intron|GNAL_uc002kqd.2_Intron|GNAL_uc010wzt.1_Intron	NM_001142339	NP_001135811			guanine nucleotide binding protein (G protein),						activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1																		---	---	---	---
SPIRE1	56907	broad.mit.edu	37	18	12450366	12450366	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12450366delA	uc002kre.2	-						SPIRE1_uc002krc.2_Intron|SPIRE1_uc010wzw.1_Intron|SPIRE1_uc010wzx.1_Intron|SPIRE1_uc010wzy.1_Intron	NM_001128626	NP_001122098			spire homolog 1 isoform a							cytoskeleton|perinuclear region of cytoplasm	actin binding				0																		---	---	---	---
ZNF519	162655	broad.mit.edu	37	18	14124177	14124182	+	Intron	DEL	AAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14124177_14124182delAAAAAA	uc002kst.1	-						ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330			zinc finger protein 519						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
RBBP8	5932	broad.mit.edu	37	18	20526616	20526616	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20526616delT	uc002ktw.2	+						RBBP8_uc002kty.2_Intron|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Intron|RBBP8_uc002ktx.1_Intron	NM_002894	NP_002885			retinoblastoma binding protein 8 isoform a						cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
RBBP8	5932	broad.mit.edu	37	18	20596911	20596911	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20596911delT	uc002ktw.2	+						RBBP8_uc002kty.2_Intron|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Intron|RBBP8_uc010xap.1_Intron	NM_002894	NP_002885			retinoblastoma binding protein 8 isoform a						cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21479058	21479058	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21479058delT	uc002kuq.2	+						LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Intron|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762			laminin alpha 3 subunit isoform 1						cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
DSG4	147409	broad.mit.edu	37	18	28989924	28989924	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28989924delT	uc002kwq.2	+						DSG4_uc002kwr.2_Intron	NM_177986	NP_817123			desmoglein 4 isoform 2 preproprotein						homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)															---	---	---	---
MEP1B	4225	broad.mit.edu	37	18	29770169	29770169	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29770169delT	uc002kxj.3	+							NM_005925	NP_005916			meprin A beta precursor						digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
DTNA	1837	broad.mit.edu	37	18	32457924	32457924	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:32457924delT	uc010dmn.1	+						DTNA_uc002kxw.2_Intron|DTNA_uc010dmj.2_Intron|DTNA_uc002kxz.2_Intron|DTNA_uc002kxy.2_Intron|DTNA_uc010xby.1_Intron|DTNA_uc010xbz.1_Intron|DTNA_uc010xca.1_Intron|DTNA_uc002kye.2_Intron	NM_001390	NP_001381			dystrobrevin alpha isoform 1						neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0																		---	---	---	---
C18orf10	25941	broad.mit.edu	37	18	34378660	34378660	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34378660delA	uc002kzw.1	-						C18orf10_uc002kzv.1_Intron|C18orf10_uc010xci.1_Intron|C18orf10_uc002kzx.1_Intron|C18orf10_uc002kzy.3_Intron	NM_015476	NP_056291			tubulin polyglutamylase complex subunit 2							cytoplasm|microtubule				skin(1)	1																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43529365	43529365	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43529365delT	uc002lbm.2	-						KIAA1632_uc002lbo.1_Intron	NM_020964	NP_066015			hypothetical protein LOC57724						autophagy						0																		---	---	---	---
SKA1	220134	broad.mit.edu	37	18	47918723	47918726	+	3'UTR	DEL	TTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47918723_47918726delTTTT	uc002let.2	+	7					SKA1_uc002leu.2_3'UTR|SKA1_uc010xdl.1_3'UTR	NM_145060	NP_659497			spindle and KT associated 1						cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0																		---	---	---	---
SMAD4	4089	broad.mit.edu	37	18	48573269	48573270	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:48573269_48573270delTT	uc010xdp.1	+						SMAD4_uc010xdo.1_Intron	NM_005359	NP_005350			mothers against decapentaplegic homolog 4						BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity			pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)										Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54278334	54278334	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54278334delA	uc002lgg.2	-						TXNL1_uc010xdz.1_Intron|TXNL1_uc002lgh.2_Intron|TXNL1_uc002lgi.2_Intron|TXNL1_uc002lgj.1_Intron	NM_004786	NP_004777			thioredoxin-like 1						cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
Unknown	0	broad.mit.edu	37	18	65042307	65042309	+	IGR	DEL	TTT	-	-	rs75002100		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65042307_65042309delTTT								CDH19 (771091 upstream) : DSEL (131510 downstream)																																			---	---	---	---
C18orf55	29090	broad.mit.edu	37	18	71825155	71825155	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:71825155delT	uc010dqr.1	+							NM_014177	NP_054896			hypothetical protein LOC29090 precursor						protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)																---	---	---	---
PRSSL1	400668	broad.mit.edu	37	19	691213	691213	+	Intron	DEL	A	-	-	rs147436553		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:691213delA	uc002lpl.1	-						PRSSL1_uc010xfs.1_Intron	NM_214710	NP_999875			protease, serine-like 1 precursor						proteolysis	extracellular region	serine-type endopeptidase activity				0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MIDN	90007	broad.mit.edu	37	19	1257516	1257517	+	3'UTR	INS	-	TCC	TCC	rs78673746		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1257516_1257517insTCC	uc002lrp.2	+	8						NM_177401	NP_796375			midnolin							nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SLC25A41	284427	broad.mit.edu	37	19	6432330	6432330	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6432330delT	uc010dus.2	-						SLC25A41_uc010dut.2_Intron	NM_173637	NP_775908			solute carrier family 25, member 41						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
CRB3	92359	broad.mit.edu	37	19	6464817	6464817	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6464817delG	uc002mey.2	+						CRB3_uc002mez.2_Intron|CRB3_uc002mfa.2_Intron	NM_139161	NP_631900			crumbs 3 isoform a precursor						protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0																		---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6469736	6469736	+	Intron	DEL	T	-	-	rs74772168		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6469736delT	uc002mfe.2	-						DENND1C_uc002mfb.2_Intron|DENND1C_uc002mfc.2_Intron|DENND1C_uc002mfd.2_Intron|DENND1C_uc010xje.1_Intron	NM_024898	NP_079174			DENN/MADD domain containing 1C							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
CD70	970	broad.mit.edu	37	19	6593296	6593297	+	5'Flank	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6593296_6593297insA	uc002mfi.2	-						CD70_uc010xjf.1_5'Flank	NM_001252	NP_001243			tumor necrosis factor ligand superfamily, member						cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to membrane of membrane fraction|integral to plasma membrane	cytokine activity|protease binding|tumor necrosis factor receptor binding				0																		---	---	---	---
AP1M2	10053	broad.mit.edu	37	19	10688100	10688117	+	Intron	DEL	TTTTTTTTTTTTTTTTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10688100_10688117delTTTTTTTTTTTTTTTTTT	uc002mpc.2	-						AP1M2_uc002mpd.2_Intron	NM_005498	NP_005489			adaptor-related protein complex 1, mu 2 subunit						cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	12670276	12670276	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12670276delA								ZNF709 (7920 upstream) : ZNF490 (16644 downstream)																																			---	---	---	---
CC2D1A	54862	broad.mit.edu	37	19	14030491	14030493	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14030491_14030493delAAA	uc002mxo.2	+						CC2D1A_uc002mxn.2_Intron|CC2D1A_uc002mxp.2_Intron|CC2D1A_uc010dzh.2_Intron|CC2D1A_uc002mxq.1_Intron	NM_017721	NP_060191			coiled-coil and C2 domain containing 1A						positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)															---	---	---	---
NDUFB7	4713	broad.mit.edu	37	19	14682803	14682803	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14682803delG	uc002mzg.2	-	1	84	c.10delC	c.(10-12)CACfs	p.H4fs		NM_004146	NP_004137	P17568	NDUB7_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	4					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)													---	---	---	---
HAUS8	93323	broad.mit.edu	37	19	17163387	17163387	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17163387delA	uc002nfe.2	-						HAUS8_uc002nff.2_Intron|HAUS8_uc002nfg.1_Intron|HAUS8_uc002nfh.1_Intron	NM_033417	NP_219485			sarcoma antigen NY-SAR-48 isoform a						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0																OREG0025339	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17753825	17753825	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17753825delT	uc002nhd.2	-							NM_001080421	NP_001073890			unc-13 homolog A						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
IL12RB1	3594	broad.mit.edu	37	19	18197762	18197762	+	5'Flank	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18197762delA	uc002nhw.1	-						IL12RB1_uc010xqb.1_5'Flank|IL12RB1_uc002nhx.1_Intron|IL12RB1_uc002nhy.2_5'Flank	NM_005535	NP_005526			interleukin 12 receptor, beta 1 isoform 1						cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1																		---	---	---	---
PIK3R2	5296	broad.mit.edu	37	19	18273703	18273703	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18273703delA	uc002nia.1	+						PIK3R2_uc002nib.1_Intron|PIK3R2_uc010ebi.1_Intron	NM_005027	NP_005018			phosphoinositide-3-kinase, regulatory subunit 2						fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	20442507	20442508	+	IGR	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20442507_20442508delTT								LOC284441 (72004 upstream) : ZNF826 (8570 downstream)																																			---	---	---	---
ZNF430	80264	broad.mit.edu	37	19	21217112	21217112	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21217112delT	uc002npj.2	+						ZNF430_uc002npk.2_Intron	NM_025189	NP_079465			zinc finger protein 430						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2																		---	---	---	---
ZNF100	163227	broad.mit.edu	37	19	21925519	21925520	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21925519_21925520insA	uc002nqi.2	-						ZNF100_uc002nqh.2_Intron	NM_173531	NP_775802			zinc finger protein 100						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
CCNE1	898	broad.mit.edu	37	19	30314459	30314460	+	Intron	DEL	AA	-	-	rs4805483	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30314459_30314460delAA	uc002nsn.2	+						CCNE1_uc002nso.2_Intron|CCNE1_uc002nsp.2_Intron	NM_001238	NP_001229			cyclin E1 isoform 1						androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)															---	---	---	---
WDR88	126248	broad.mit.edu	37	19	33628475	33628475	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33628475delT	uc002nui.2	+							NM_173479	NP_775750			PQQ repeat and WD repeat domain containing											ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)																	---	---	---	---
HAUS5	23354	broad.mit.edu	37	19	36104496	36104496	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36104496delA	uc002oam.1	+							NM_015302	NP_056117			HAUS augmin-like complex, subunit 5						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0																		---	---	---	---
ZNF585B	92285	broad.mit.edu	37	19	37681158	37681159	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37681158_37681159delTT	uc002ofq.2	-						ZNF585B_uc002ofr.1_Intron	NM_152279	NP_689492			zinc finger protein 585B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF569	148266	broad.mit.edu	37	19	37918654	37918654	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37918654delA	uc002ogi.2	-						ZNF569_uc002ogh.2_Intron|ZNF569_uc002ogj.2_Intron	NM_152484	NP_689697			zinc finger protein 569						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
CATSPERG	57828	broad.mit.edu	37	19	38851085	38851085	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38851085delC	uc002oih.3	+						CATSPERG_uc002oig.3_Intron|CATSPERG_uc002oif.3_Intron|CATSPERG_uc010efw.2_Intron	NM_021185	NP_067008			cation channel, sperm-associated, gamma						cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
RYR1	6261	broad.mit.edu	37	19	38963871	38963871	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38963871delC	uc002oit.2	+						RYR1_uc002oiu.2_Intron	NM_000540	NP_000531			skeletal muscle ryanodine receptor isoform 1						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
CAPN12	147968	broad.mit.edu	37	19	39225998	39225998	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39225998delC	uc002ojd.1	-						CAPN12_uc010egd.1_Intron|CAPN12_uc002ojc.1_Intron	NM_144691	NP_653292			calpain 12						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)															---	---	---	---
CAPN12	147968	broad.mit.edu	37	19	39232227	39232229	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39232227_39232229delAAA	uc002ojd.1	-							NM_144691	NP_653292			calpain 12						proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	42989130	42989130	+	Intron	DEL	T	-	-	rs76061290		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42989130delT	uc010eif.1	+						uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron					Homo sapiens cDNA FLJ39530 fis, clone PUAEN2004400.																														---	---	---	---
PHLDB3	653583	broad.mit.edu	37	19	44005877	44005880	+	Intron	DEL	CAAA	-	-	rs112058634		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44005877_44005880delCAAA	uc002own.3	-						PHLDB3_uc002owo.2_Intron	NM_198850	NP_942147			pleckstrin homology-like domain, family B,												0		Prostate(69;0.0153)																---	---	---	---
KCNN4	3783	broad.mit.edu	37	19	44272893	44272894	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44272893_44272894delTT	uc002oxl.2	-						KCNN4_uc010eiz.2_Intron	NM_002250	NP_002241			intermediate conductance calcium-activated						defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)													---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45316993	45316993	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45316993delA	uc002ozu.2	+						BCAM_uc002ozt.1_Intron	NM_005581	NP_005572			basal cell adhesion molecule isoform 1						cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
PPP5C	5536	broad.mit.edu	37	19	46850393	46850393	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46850393delC	uc002pem.2	+	1	100	c.40delC	c.(40-42)CCCfs	p.P14fs	PPP5C_uc010xya.1_5'UTR|PPP5C_uc002pen.2_Frame_Shift_Del_p.P14fs	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	14					mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)												OREG0025570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
AP2S1	1175	broad.mit.edu	37	19	47353980	47353980	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47353980delC	uc002pft.1	-						AP2S1_uc002pfu.1_Intron	NM_004069	NP_004060			adaptor-related protein complex 2, sigma 1						axon guidance|clathrin coat assembly|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|regulation of endocytosis|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	protein transporter activity				0		all_cancers(25;1.24e-06)|all_epithelial(76;1.09e-05)|all_lung(116;0.00019)|Lung NSC(112;0.000601)|Ovarian(192;0.0221)|all_neural(266;0.0459)|Breast(70;0.128)		OV - Ovarian serous cystadenocarcinoma(262;3.86e-05)|all cancers(93;0.000107)|Epithelial(262;0.00325)|GBM - Glioblastoma multiforme(486;0.0336)														---	---	---	---
NAPA	8775	broad.mit.edu	37	19	48006777	48006777	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48006777delA	uc002pha.1	-						NAPA_uc002phb.1_Intron|NAPA_uc002phc.1_Intron|NAPA_uc002phd.1_Intron|NAPA_uc010elf.1_Intron|NAPA_uc010elg.1_Intron|NAPA_uc002phe.2_Intron	NM_003827	NP_003818			N-ethylmaleimide-sensitive factor attachment						cellular membrane fusion|intra-Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport	cytosol					0		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000466)|all cancers(93;0.000739)|Epithelial(262;0.0168)|GBM - Glioblastoma multiforme(486;0.049)														---	---	---	---
PLEKHA4	57664	broad.mit.edu	37	19	49355300	49355300	+	Intron	DEL	A	-	-	rs148248855	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49355300delA	uc002pkx.2	-						PLEKHA4_uc002pkw.1_Intron|PLEKHA4_uc010eml.2_Intron	NM_020904	NP_065955			pleckstrin homology domain containing family A							cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)														---	---	---	---
SCAF1	58506	broad.mit.edu	37	19	50158042	50158042	+	Frame_Shift_Del	DEL	C	-	-	rs149487378	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50158042delC	uc002poq.2	+	9	3657	c.3533delC	c.(3532-3534)ACCfs	p.T1178fs		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1178					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)														---	---	---	---
MED25	81857	broad.mit.edu	37	19	50322712	50322712	+	Intron	DEL	G	-	-	rs115074359	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50322712delG	uc002ppw.1	+						MED25_uc010ybe.1_Intron|MED25_uc010enl.1_3'UTR	NM_030973	NP_112235			mediator complex subunit 25						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)														---	---	---	---
C19orf41	126123	broad.mit.edu	37	19	50665879	50665879	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50665879delA	uc002prp.1	-							NM_152358	NP_689571			hypothetical protein LOC126123 precursor							integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)														---	---	---	---
NLRP7	199713	broad.mit.edu	37	19	55452576	55452578	+	Intron	DEL	AAA	-	-	rs111382825		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55452576_55452578delAAA	uc002qih.3	-						NLRP7_uc002qig.3_Intron|NLRP7_uc002qii.3_Intron|NLRP7_uc010esk.2_Intron|NLRP7_uc010esl.2_Intron	NM_206828	NP_996611			NACHT, leucine rich repeat and PYD containing 7								ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
IL11	3589	broad.mit.edu	37	19	55877435	55877435	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55877435delC	uc002qks.1	-	5	676	c.540delG	c.(538-540)GGGfs	p.G180fs	FAM71E2_uc002qkr.2_5'Flank|FAM71E2_uc002qkq.2_5'Flank|IL11_uc010yfx.1_Frame_Shift_Del_p.G101fs	NM_000641	NP_000632	P20809	IL11_HUMAN	interleukin 11 precursor	180					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding				0	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)													---	---	---	---
AURKC	6795	broad.mit.edu	37	19	57745123	57745123	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57745123delT	uc002qoe.2	+						AURKC_uc002qoc.2_Intron|AURKC_uc002qod.2_Intron|AURKC_uc010etv.2_Intron	NM_001015878	NP_001015878			aurora kinase C isoform 1						cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)														---	---	---	---
VPS16	64601	broad.mit.edu	37	20	2844407	2844408	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2844407_2844408insA	uc002whe.2	+						VPS16_uc002whh.2_Intron|PTPRA_uc002whj.2_5'Flank|VPS16_uc002whf.2_Intron|VPS16_uc002whd.2_Intron|VPS16_uc002whg.2_Intron|VPS16_uc002whi.2_5'Flank	NM_022575	NP_072097			vacuolar protein sorting 16 isoform 1						intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
ATRN	8455	broad.mit.edu	37	20	3619684	3619684	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3619684delT	uc002wim.2	+							NM_139321	NP_647537			attractin isoform 1						inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2																		---	---	---	---
TRMT6	51605	broad.mit.edu	37	20	5924808	5924808	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5924808delT	uc002wmh.1	-	4	580	c.458delA	c.(457-459)AAAfs	p.K153fs	TRMT6_uc010zra.1_5'UTR|TRMT6_uc010gbn.1_5'UTR|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	153					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1																		---	---	---	---
C20orf7	79133	broad.mit.edu	37	20	13769424	13769424	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13769424delT	uc002wom.2	+						C20orf7_uc002wol.1_Intron|C20orf7_uc002won.2_Intron|C20orf7_uc002woo.2_Intron	NM_024120	NP_077025			hypothetical protein LOC79133 isoform 1						mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity				0		Myeloproliferative disorder(85;0.00878)																---	---	---	---
MACROD2	140733	broad.mit.edu	37	20	15843206	15843207	+	Intron	DEL	CA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:15843206_15843207delCA	uc002wou.2	+						MACROD2_uc002wot.2_Intron|MACROD2_uc002woz.2_Intron|MACROD2_uc002wpb.2_Intron	NM_080676	NP_542407			MACRO domain containing 2 isoform 1												0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)																---	---	---	---
ID1	3397	broad.mit.edu	37	20	30193732	30193732	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30193732delG	uc002wwg.1	+						ID1_uc002wwh.1_3'UTR|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156			inhibitor of DNA binding 1 isoform a						angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)															---	---	---	---
ZNF341	84905	broad.mit.edu	37	20	32376885	32376887	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32376885_32376887delTTT	uc002wzy.2	+						ZNF341_uc002wzx.2_Intron|ZNF341_uc010geq.2_Intron|ZNF341_uc010ger.2_Intron|ZNF341_uc002wzz.2_Intron	NM_032819	NP_116208			zinc finger protein 341						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
RPN2	6185	broad.mit.edu	37	20	35836061	35836061	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35836061delT	uc002xgp.2	+						RPN2_uc002xgo.3_Intron|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Intron	NM_002951	NP_002942			ribophorin II isoform 1 precursor						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
SLC13A3	64849	broad.mit.edu	37	20	45228423	45228423	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45228423delT	uc002xsf.1	-						SLC13A3_uc010ghn.1_Intron|SLC13A3_uc010zxw.1_Intron|SLC13A3_uc002xsg.1_Intron|SLC13A3_uc010gho.1_Intron|SLC13A3_uc010zxx.1_Intron	NM_022829	NP_073740			solute carrier family 13 member 3 isoform a							integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)													---	---	---	---
C20orf108	116151	broad.mit.edu	37	20	54941514	54941514	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54941514delT	uc002xxc.2	+	3						NM_080821	NP_543011			hypothetical protein LOC116151							integral to membrane					0			Colorectal(105;0.202)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58456449	58456449	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58456449delA	uc002yaz.2	-							NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
APP	351	broad.mit.edu	37	21	27354820	27354820	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:27354820delA	uc002ylz.2	-						APP_uc010glk.2_Intron|APP_uc002yma.2_Intron|APP_uc011ach.1_Intron|APP_uc002ymb.2_Intron|APP_uc010glj.2_Intron|APP_uc011aci.1_Intron	NM_000484	NP_000475			amyloid beta A4 protein isoform a precursor						adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)																---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30332708	30332708	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30332708delA	uc002ymr.2	-							NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
SON	6651	broad.mit.edu	37	21	34915619	34915620	+	Intron	INS	-	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34915619_34915620insC	uc002yse.1	+						GART_uc002yrx.2_5'Flank|GART_uc002yrz.2_5'Flank|GART_uc010gmd.2_5'Flank|GART_uc002yry.2_5'Flank|GART_uc002ysa.2_5'Flank|SON_uc002ysb.1_Intron|SON_uc002ysc.2_Intron|SON_uc002ysd.2_Intron|SON_uc002ysf.1_Intron	NM_138927	NP_620305			SON DNA-binding protein isoform F						anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6																		---	---	---	---
DONSON	29980	broad.mit.edu	37	21	34956724	34956724	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34956724delA	uc002ysk.2	-						DONSON_uc002ysi.1_Intron|DONSON_uc002ysj.2_Intron|DONSON_uc002ysl.2_Intron|DONSON_uc010gme.2_Intron|DONSON_uc002ysm.2_Intron	NM_017613	NP_060083			downstream neighbor of SON						multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
DSCAM	1826	broad.mit.edu	37	21	41551112	41551125	+	Intron	DEL	AAAAAAAAAAAAAA	-	-	rs72113251		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:41551112_41551125delAAAAAAAAAAAAAA	uc002yyq.1	-						DSCAM_uc002yyr.1_Intron	NM_001389	NP_001380			Down syndrome cell adhesion molecule isoform						cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)																---	---	---	---
UMODL1	89766	broad.mit.edu	37	21	43542773	43542774	+	Intron	DEL	GT	-	-	rs111885176		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43542773_43542774delGT	uc002zaf.1	+						UMODL1_uc002zad.1_Intron|UMODL1_uc002zae.1_Intron|UMODL1_uc002zag.1_Intron|UMODL1_uc002zal.1_Intron	NM_001004416	NP_001004416			uromodulin-like 1 isoform 1 precursor							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
PKNOX1	5316	broad.mit.edu	37	21	44436921	44436921	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44436921delT	uc002zcq.1	+						PKNOX1_uc002zcp.1_Intron|PKNOX1_uc011aex.1_Intron|PKNOX1_uc002zcr.2_Intron	NM_004571	NP_004562			PBX/knotted 1 homeobox 1								sequence-specific DNA binding			large_intestine(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	17071583	17071583	+	IGR	DEL	A	-	-	rs113596080		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17071583delA								OR11H1 (621779 upstream) : CCT8L2 (65 downstream)																																			---	---	---	---
HIRA	7290	broad.mit.edu	37	22	19363400	19363400	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19363400delA	uc002zpf.1	-						HIRA_uc011agx.1_Intron|HIRA_uc010grn.1_Intron|HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron	NM_003325	NP_003316			HIR histone cell cycle regulation defective						chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)																	---	---	---	---
Unknown	0	broad.mit.edu	37	22	23712779	23712779	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23712779delA								BCR (52556 upstream) : ZDHHC8P1 (20014 downstream)																																			---	---	---	---
INPP5J	27124	broad.mit.edu	37	22	31523892	31523892	+	Intron	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31523892delC	uc003aju.3	+						INPP5J_uc003ajv.3_Intron|INPP5J_uc003ajs.3_Intron|INPP5J_uc011alk.1_Intron|INPP5J_uc010gwg.2_Intron|INPP5J_uc003ajw.2_Intron|INPP5J_uc003ajt.3_Intron|INPP5J_uc003ajx.2_5'UTR|INPP5J_uc003ajy.2_5'UTR|INPP5J_uc003ajz.2_5'UTR	NM_001002837	NP_001002837			phosphatidylinositol (4,5) bisphosphate							cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1																		---	---	---	---
EIF4ENIF1	56478	broad.mit.edu	37	22	31850085	31850085	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31850085delA	uc003akz.1	-						EIF4ENIF1_uc003akx.1_Intron|EIF4ENIF1_uc003aky.1_Intron|EIF4ENIF1_uc003ala.1_Intron|EIF4ENIF1_uc003alb.1_Intron|EIF4ENIF1_uc003akw.1_5'Flank	NM_019843	NP_062817			eukaryotic translation initiation factor 4E							nucleus	protein binding|protein transporter activity			ovary(1)	1																		---	---	---	---
C22orf42	150297	broad.mit.edu	37	22	32550002	32550003	+	Intron	INS	-	CA	CA	rs111234718		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32550002_32550003insCA	uc003amd.2	-							NM_001010859	NP_001010859			chromosome 22 open reading frame 42											ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	32675477	32675477	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32675477delA								SLC5A4 (24159 upstream) : RFPL3 (75395 downstream)																																			---	---	---	---
FBXO7	25793	broad.mit.edu	37	22	32881417	32881417	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32881417delT	uc003amq.2	+						FBXO7_uc003amp.1_Intron|FBXO7_uc003amr.2_Intron|FBXO7_uc003ams.2_Intron|FBXO7_uc003amt.2_Intron|FBXO7_uc003amu.2_Intron	NM_012179	NP_036311			F-box only protein 7 isoform 1						cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
SYN3	8224	broad.mit.edu	37	22	32914355	32914355	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32914355delT	uc003amx.2	-						SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron|SYN3_uc011amc.1_Intron	NM_003490	NP_003481			synapsin III isoform IIIa						neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1																		---	---	---	---
TNRC6B	23112	broad.mit.edu	37	22	40708460	40708460	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40708460delT	uc011aor.1	+						TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Intron|TNRC6B_uc003ayo.2_Intron	NM_001162501	NP_001155973			trinucleotide repeat containing 6B isoform 1						gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0																		---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40813065	40813067	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40813065_40813067delAAA	uc003ayv.1	-						MKL1_uc003ayw.1_Intron|MKL1_uc010gye.1_Intron|MKL1_uc010gyf.1_Intron	NM_020831	NP_065882			megakaryoblastic leukemia 1 protein						positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
XPNPEP3	63929	broad.mit.edu	37	22	41264850	41264850	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41264850delA	uc003azh.2	+						XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_Intron|XPNPEP3_uc010gyh.1_Intron	NM_022098	NP_071381			X-prolyl aminopeptidase (aminopeptidase P) 3,						cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	41585707	41585708	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41585707_41585708insT	uc003azm.2	-											Homo sapiens, clone IMAGE:5580334, mRNA.																														---	---	---	---
MEI1	150365	broad.mit.edu	37	22	42144055	42144055	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42144055delT	uc003baz.1	+						WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|MEI1_uc011apd.1_Intron	NM_152513	NP_689726			meiosis defective 1								binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
WBP2NL	164684	broad.mit.edu	37	22	42396997	42396997	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42396997delA	uc011ape.1	+						WBP2NL_uc003bbt.2_Intron|WBP2NL_uc011apk.1_Intron|WBP2NL_uc003bbu.2_Intron	NM_152613	NP_689826			WBP2 N-terminal like						egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2																		---	---	---	---
SMC1B	27127	broad.mit.edu	37	22	45754477	45754477	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45754477delA	uc003bgc.2	-						SMC1B_uc003bgd.2_Intron	NM_148674	NP_683515			SMC1 structural maintenance of chromosomes						chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
CSF2RA	1438	broad.mit.edu	37	X	1409087	1409087	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1409087delT	uc010nct.2	+						CSF2RA_uc011mhb.1_Intron|CSF2RA_uc004cpq.2_Intron|CSF2RA_uc004cpn.2_Intron|CSF2RA_uc004cpo.2_Intron|CSF2RA_uc010ncu.2_Intron|CSF2RA_uc011mhc.1_Intron|CSF2RA_uc004cpp.2_Intron|CSF2RA_uc010ncv.2_Intron|CSF2RA_uc004cpr.2_Intron	NM_001161529	NP_001155001			colony stimulating factor 2 receptor alpha chain							extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)													---	---	---	---
ASMTL	8623	broad.mit.edu	37	X	1547163	1547163	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1547163delA	uc004cpx.1	-						ASMTL_uc011mhe.1_Intron|ASMTL_uc004cpy.1_Intron|ASMTL_uc011mhf.1_Intron	NM_004192	NP_004183			acetylserotonin O-methyltransferase-like						melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
ARSF	416	broad.mit.edu	37	X	2986258	2986258	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:2986258delT	uc004cre.1	+						ARSF_uc004crf.1_Intron	NM_004042	NP_004033			arylsulfatase F precursor							extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
FAM9A	171482	broad.mit.edu	37	X	8764320	8764320	+	Frame_Shift_Del	DEL	T	-	-	rs1985393		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:8764320delT	uc004csg.2	-	6	588	c.477delA	c.(475-477)AAAfs	p.K159fs		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	159						nucleolus					0		Hepatocellular(5;0.219)																---	---	---	---
WWC3	55841	broad.mit.edu	37	X	10096842	10096842	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10096842delG	uc004csx.3	+						WWC3_uc010nds.2_Intron|WWC3_uc010ndt.2_Intron	NM_015691	NP_056506			WWC family member 3											ovary(4)	4																		---	---	---	---
ARHGAP6	395	broad.mit.edu	37	X	11243974	11243974	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11243974delT	uc004cup.1	-						ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cum.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc010neb.1_Intron|ARHGAP6_uc011mif.1_Intron	NM_013427	NP_038286			Rho GTPase activating protein 6 isoform 1						actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2																		---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11777824	11777824	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11777824delA	uc004cuw.2	+						MSL3_uc004cuv.1_Intron|MSL3_uc004cux.2_Intron|MSL3_uc011mig.1_Intron|MSL3_uc011mih.1_Intron|MSL3_uc004cuy.2_5'UTR|MSL3_uc011mii.1_5'Flank	NM_078629	NP_523353			male-specific lethal 3-like 1 isoform a						histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11792981	11792981	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11792981delT	uc004cuw.2	+						MSL3_uc004cux.2_Intron|MSL3_uc011mig.1_Intron|MSL3_uc011mih.1_Intron|MSL3_uc004cuy.2_Intron	NM_078629	NP_523353			male-specific lethal 3-like 1 isoform a						histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
GEMIN8	54960	broad.mit.edu	37	X	14039511	14039512	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14039511_14039512insA	uc004cwb.2	-						GEMIN8_uc004cwc.2_Intron|GEMIN8_uc004cwd.2_Intron	NM_017856	NP_060326			gem (nuclear organelle) associated protein 8						spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0																		---	---	---	---
GLRA2	2742	broad.mit.edu	37	X	14548222	14548222	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14548222delT	uc010nep.2	+	2	375	c.43delT	c.(43-45)TTTfs	p.F15fs	GLRA2_uc010neq.2_Frame_Shift_Del_p.F15fs|GLRA2_uc004cwe.3_Frame_Shift_Del_p.F15fs|GLRA2_uc011mio.1_5'UTR|GLRA2_uc011mip.1_5'Flank	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	15					neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)													---	---	---	---
GLRA2	2742	broad.mit.edu	37	X	14592332	14592332	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14592332delT	uc010nep.2	+						GLRA2_uc010neq.2_Intron|GLRA2_uc004cwe.3_Intron|GLRA2_uc011mio.1_Intron|GLRA2_uc011mip.1_Intron	NM_001118885	NP_001112357			glycine receptor, alpha 2 isoform A						neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)													---	---	---	---
ASB9	140462	broad.mit.edu	37	X	15273107	15273109	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15273107_15273109delAAA	uc004cwl.2	-						ASB9_uc004cwk.2_Intron|ASB9_uc004cwm.2_Intron|ASB9_uc010ner.2_Intron|ASB9_uc004cwn.2_Intron	NM_001031739	NP_001026909			ankyrin repeat and SOCS box-containing 9 isoform						intracellular signal transduction						0	Hepatocellular(33;0.183)																	---	---	---	---
BMX	660	broad.mit.edu	37	X	15529702	15529702	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15529702delT	uc004cww.2	+						BMX_uc004cwx.3_Intron|BMX_uc004cwy.3_Intron	NM_203281	NP_975010			BMX non-receptor tyrosine kinase						cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16635189	16635189	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16635189delA	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16707832	16707833	+	Intron	INS	-	AC	AC			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16707832_16707833insAC	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16716680	16716682	+	Intron	DEL	TTT	-	-	rs72307111		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16716680_16716682delTTT	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
SYAP1	94056	broad.mit.edu	37	X	16754276	16754276	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16754276delT	uc004cxp.2	+						SYAP1_uc004cxo.2_Intron|SYAP1_uc011miv.1_Intron	NM_032796	NP_116185			SYAP1 protein											skin(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
NHS	4810	broad.mit.edu	37	X	17743355	17743356	+	Intron	DEL	AA	-	-	rs10712155		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17743355_17743356delAA	uc004cxx.2	+						NHS_uc011mix.1_Intron|NHS_uc004cxy.2_Intron|NHS_uc004cxz.2_Intron|NHS_uc004cya.2_Intron	NM_198270	NP_938011			Nance-Horan syndrome protein isoform 1							nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)																	---	---	---	---
CDKL5	6792	broad.mit.edu	37	X	18665265	18665265	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18665265delT	uc004cym.2	+						CDKL5_uc004cyn.2_Intron|RS1_uc004cyo.2_Intron	NM_003159	NP_003150			cyclin-dependent kinase-like 5						neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18779590	18779590	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18779590delA	uc004cyq.2	+						PPEF1_uc004cyp.2_Intron|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Intron|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_Intron	NM_006240	NP_006231			protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PPEF1	5475	broad.mit.edu	37	X	18800473	18800473	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18800473delT	uc004cyq.2	+						PPEF1_uc004cyp.2_Intron|PPEF1_uc004cyr.2_Intron|PPEF1_uc004cys.2_Intron|PPEF1_uc011mja.1_Intron|PPEF1_uc011mjb.1_Intron	NM_006240	NP_006231			protein phosphatase with EF hand calcium-binding						detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18957012	18957012	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18957012delT	uc004cyv.3	-							NM_000292	NP_000283			phosphorylase kinase, alpha 2 (liver)						glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18958201	18958201	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18958201delA	uc004cyv.3	-							NM_000292	NP_000283			phosphorylase kinase, alpha 2 (liver)						glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
SH3KBP1	30011	broad.mit.edu	37	X	19560215	19560215	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19560215delG	uc004czm.2	-	16	2036	c.1720delC	c.(1720-1722)CTGfs	p.L574fs	SH3KBP1_uc011mje.1_Frame_Shift_Del_p.L313fs|SH3KBP1_uc011mjf.1_Frame_Shift_Del_p.L336fs|SH3KBP1_uc004czl.2_Frame_Shift_Del_p.L537fs|SH3KBP1_uc010nfm.2_Frame_Shift_Del_p.L19fs	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	574					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0																		---	---	---	---
EIF1AX	1964	broad.mit.edu	37	X	20156586	20156586	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20156586delA	uc004czt.2	-						SCARNA9L_uc010nfp.2_5'Flank	NM_001412	NP_001403			X-linked eukaryotic translation initiation							cytosol	translation initiation factor activity			ovary(1)	1																		---	---	---	---
RPS6KA3	6197	broad.mit.edu	37	X	20174513	20174513	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20174513delA	uc004czu.2	-						RPS6KA3_uc011mjk.1_Intron|RPS6KA3_uc004czv.2_Intron|RPS6KA3_uc011mjl.1_Intron|RPS6KA3_uc011mjm.1_Intron	NM_004586	NP_004577			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8																		---	---	---	---
SMS	6611	broad.mit.edu	37	X	21989955	21989958	+	Intron	DEL	TCTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21989955_21989958delTCTT	uc004dag.2	+						SMS_uc011mjq.1_Intron|SMS_uc004daf.1_Intron	NM_004595	NP_004586			spermine synthase						methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)													---	---	---	---
PTCHD1	139411	broad.mit.edu	37	X	23412420	23412429	+	3'UTR	DEL	AAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23412420_23412429delAAAAAAAAAA	uc004dal.3	+	3						NM_173495	NP_775766			patched domain containing 1						cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6																		---	---	---	---
PRDX4	10549	broad.mit.edu	37	X	23701827	23701828	+	Intron	INS	-	TA	TA			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23701827_23701828insTA	uc004dam.2	+							NM_006406	NP_006397			peroxiredoxin 4						cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
SAT1	6303	broad.mit.edu	37	X	23802147	23802147	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23802147delA	uc004dau.2	+						SAT1_uc010nfv.2_Frame_Shift_Del_p.K117fs|SAT1_uc004dav.2_Intron	NM_002970	NP_002961			diamine N-acetyltransferase 1						angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)													---	---	---	---
CXorf58	254158	broad.mit.edu	37	X	23934573	23934573	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23934573delT	uc004daz.1	+						CXorf58_uc011mju.1_Intron	NM_152761	NP_689974			hypothetical protein LOC254158												0																		---	---	---	---
ZFX	7543	broad.mit.edu	37	X	24225361	24225367	+	Intron	DEL	AATTTTT	-	-	rs62796264		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24225361_24225367delAATTTTT	uc004dbf.2	+						ZFX_uc004dbd.1_Intron|ZFX_uc010nfx.1_Intron|ZFX_uc004dbe.2_Intron|ZFX_uc011mjv.1_Intron|ZFX_uc010nfy.1_Intron|ZFX_uc010nfz.2_5'Flank	NM_003410	NP_003401			zinc finger protein, X-linked						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	24447607	24447610	+	IGR	DEL	TTTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24447607_24447610delTTTT								FAM48B1 (64067 upstream) : PDK3 (35734 downstream)																																			---	---	---	---
DMD	1756	broad.mit.edu	37	X	33229458	33229458	+	5'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:33229458delA	uc004dda.1	-	1					DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_5'UTR|DMD_uc004ddf.2_Intron|DMD_uc010ngr.1_5'UTR	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
Unknown	0	broad.mit.edu	37	X	36229932	36229932	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:36229932delA								CXorf59 (66745 upstream) : CXorf30 (24119 downstream)																																			---	---	---	---
RPGR	6103	broad.mit.edu	37	X	38144668	38144668	+	3'UTR	DEL	T	-	-	rs66997072		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:38144668delT	uc004ded.1	-	15					RPGR_uc004deb.2_Intron|RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025			retinitis pigmentosa GTPase regulator isoform C						intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1																		---	---	---	---
ATP6AP2	10159	broad.mit.edu	37	X	40465111	40465111	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40465111delA	uc004det.2	+	9					ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_3'UTR|ATP6AP2_uc011mkm.1_3'UTR|ATP6AP2_uc011mkn.1_3'UTR|ATP6AP2_uc004deu.1_3'UTR	NM_005765	NP_005756			ATPase, H+ transporting, lysosomal accessory						angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0																		---	---	---	---
MED14	9282	broad.mit.edu	37	X	40570654	40570654	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40570654delA	uc004dex.3	-						MED14_uc010nhe.1_Intron	NM_004229	NP_004220			mediator complex subunit 14						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	41000755	41000755	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41000755delA	uc004dfb.2	+						USP9X_uc004dfc.2_Intron	NM_001039590	NP_001034679			ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
MAOA	4128	broad.mit.edu	37	X	43591844	43591844	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:43591844delT	uc004dfy.2	+						MAOA_uc011mkw.1_Intron	NM_000240	NP_000231			monoamine oxidase A						behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)													---	---	---	---
Unknown	0	broad.mit.edu	37	X	43888675	43888675	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:43888675delA								NDP (55754 upstream) : EFHC2 (118454 downstream)																																			---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44732756	44732756	+	5'UTR	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44732756delG	uc004dge.3	+	1					KDM6A_uc010nhk.2_5'UTR|KDM6A_uc011mkz.1_5'UTR|KDM6A_uc011mla.1_5'UTR|KDM6A_uc011mlb.1_5'UTR|KDM6A_uc011mlc.1_5'UTR	NM_021140	NP_066963			ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
USP11	8237	broad.mit.edu	37	X	47107351	47107356	+	3'UTR	DEL	AAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47107351_47107356delAAAAAA	uc004dhp.2	+	21					USP11_uc004dhq.2_3'UTR	NM_004651	NP_004642			ubiquitin specific peptidase 11						protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
ELK1	2002	broad.mit.edu	37	X	47500596	47500596	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47500596delG	uc004dik.3	-						ELK1_uc010nhv.2_Intron|ELK1_uc010nhw.2_5'UTR|ELK1_uc004dil.3_Intron	NM_001114123	NP_001107595			ELK1 protein						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
WDR13	64743	broad.mit.edu	37	X	48462533	48462534	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48462533_48462534delAA	uc004dkh.1	+						WDR13_uc004dki.1_Intron|WDR13_uc004dkj.1_Intron|WDR13_uc004dkk.1_Intron|WDR13_uc004dkl.3_Intron	NM_017883	NP_060353			WD repeat domain 13 protein							cytoplasm|nucleus				ovary(2)	2																		---	---	---	---
HDAC6	10013	broad.mit.edu	37	X	48661516	48661516	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48661516delT	uc011mmi.1	+						HDAC6_uc004dkr.1_Intron|HDAC6_uc004dks.1_Intron|HDAC6_uc010nig.1_Intron|HDAC6_uc004dkt.1_Intron|HDAC6_uc004dku.3_Intron|HDAC6_uc011mmj.1_Intron|HDAC6_uc011mmk.1_Intron	NM_006044	NP_006035			histone deacetylase 6						aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)													---	---	---	---
Unknown	0	broad.mit.edu	37	X	51723046	51723046	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:51723046delT								MAGED1 (77598 upstream) : MAGED4 (81879 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	53370633	53370633	+	IGR	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53370633delC								IQSEC2 (20111 upstream) : SMC1A (30439 downstream)																																			---	---	---	---
FAM120C	54954	broad.mit.edu	37	X	54112020	54112022	+	Intron	DEL	AAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54112020_54112022delAAA	uc004dsz.3	-						FAM120C_uc011moh.1_Intron	NM_017848	NP_060318			hypothetical protein LOC54954											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
WNK3	65267	broad.mit.edu	37	X	54280342	54280342	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54280342delA	uc004dtd.1	-						WNK3_uc004dtc.1_Intron	NM_001002838	NP_001002838			WNK lysine deficient protein kinase 3 isoform 2						intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11																		---	---	---	---
FGD1	2245	broad.mit.edu	37	X	54482535	54482535	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54482535delT	uc004dtg.2	-						FGD1_uc011moi.1_Intron	NM_004463	NP_004454			faciogenital dysplasia protein						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
MAGED2	10916	broad.mit.edu	37	X	54835933	54835934	+	Intron	INS	-	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54835933_54835934insC	uc004dtk.1	+						MAGED2_uc004dtl.1_Intron|MAGED2_uc004dtm.1_Intron|MAGED2_uc010nkc.1_Intron|MAGED2_uc004dtn.1_Intron|MAGED2_uc004dto.1_5'Flank	NM_177433	NP_803182			melanoma antigen family D, 2											ovary(2)|breast(1)	3																		---	---	---	---
MAGED2	10916	broad.mit.edu	37	X	54840820	54840820	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54840820delG	uc004dtk.1	+						MAGED2_uc004dtl.1_Intron|MAGED2_uc004dtm.1_Intron|MAGED2_uc010nkc.1_Intron|MAGED2_uc004dtn.1_Intron|MAGED2_uc004dto.1_Intron|SNORA11_uc004dtp.1_RNA	NM_177433	NP_803182			melanoma antigen family D, 2											ovary(2)|breast(1)	3																		---	---	---	---
ALAS2	212	broad.mit.edu	37	X	55040196	55040196	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55040196delT	uc004dua.3	-						ALAS2_uc004dub.3_Intron|ALAS2_uc004dud.3_Intron	NM_000032	NP_000023			5-aminolevulinate synthase 2 isoform a						cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)													---	---	---	---
FAAH2	158584	broad.mit.edu	37	X	57368049	57368051	+	Intron	DEL	TTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57368049_57368051delTTT	uc004dvc.2	+							NM_174912	NP_777572			fatty acid amide hydrolase 2							integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3															HNSCC(52;0.14)			---	---	---	---
FAAH2	158584	broad.mit.edu	37	X	57458220	57458221	+	Intron	INS	-	TTTTT	TTTTT	rs6521622		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57458220_57458221insTTTTT	uc004dvc.2	+							NM_174912	NP_777572			fatty acid amide hydrolase 2							integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			ovary(3)	3															HNSCC(52;0.14)			---	---	---	---
Unknown	0	broad.mit.edu	37	X	57705150	57705152	+	IGR	DEL	CTT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57705150_57705152delCTT								ZXDB (81244 upstream) : ZXDA (229046 downstream)																																			---	---	---	---
MTMR8	55613	broad.mit.edu	37	X	63557062	63557062	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63557062delA	uc004dvs.2	-						MTMR8_uc011mou.1_Intron|MTMR8_uc004dvt.1_Intron	NM_017677	NP_060147			myotubularin related protein 8							nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	64548439	64548439	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64548439delT								ZC4H2 (293846 upstream) : ZC3H12B (160267 downstream)																																			---	---	---	---
OPHN1	4983	broad.mit.edu	37	X	67353341	67353341	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:67353341delT	uc004dww.3	-						OPHN1_uc011mpg.1_Intron	NM_002547	NP_002538			oligophrenin 1						axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2																		---	---	---	---
KIF4A	24137	broad.mit.edu	37	X	69623948	69623948	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69623948delA	uc004dyg.2	+						KIF4A_uc010nkw.2_Intron	NM_012310	NP_036442			kinesin family member 4						anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4																		---	---	---	---
ITGB1BP2	26548	broad.mit.edu	37	X	70521865	70521866	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70521865_70521866delTT	uc004dzr.1	+						BCYRN1_uc011mpt.1_Intron|ITGB1BP2_uc004dzs.1_5'UTR	NM_012278	NP_036410			integrin beta 1 binding protein 2						muscle organ development|signal transduction		SH3 domain binding			ovary(1)	1	Renal(35;0.156)																	---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70626427	70626427	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70626427delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_5'Flank|TAF1_uc010nle.1_5'Flank|TAF1_uc010nlf.1_5'Flank|TAF1_uc004dzx.2_5'Flank|TAF1_uc004dzy.2_5'Flank	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70639873	70639873	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70639873delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70643256	70643256	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70643256delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron|TAF1_uc004dzw.1_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
NHSL2	340527	broad.mit.edu	37	X	71264810	71264813	+	Intron	DEL	AAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71264810_71264813delAAAA	uc011mqa.1	+							NM_001013627	NP_001013649			NHS-like 2												0	Renal(35;0.156)																	---	---	---	---
HDAC8	55869	broad.mit.edu	37	X	71710648	71710648	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71710648delA	uc004eau.2	-						HDAC8_uc011mqe.1_Intron|HDAC8_uc011mqf.1_Intron|HDAC8_uc011mqg.1_Intron|HDAC8_uc011mqh.1_Intron|HDAC8_uc010nlk.1_Intron|HDAC8_uc004eav.2_Intron|HDAC8_uc004eaw.2_Intron	NM_018486	NP_060956			histone deacetylase 8						chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)													---	---	---	---
XIST	7503	broad.mit.edu	37	X	73071846	73071846	+	RNA	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73071846delA	uc004ebm.1	-	1		c.743delT				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0																		---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74604701	74604701	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74604701delA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
CXorf26	51260	broad.mit.edu	37	X	75393057	75393057	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:75393057delT	uc004ecl.1	+						CXorf26_uc004eck.1_Intron	NM_016500	NP_057584			hypothetical protein LOC51260												0																		---	---	---	---
ATRX	546	broad.mit.edu	37	X	76763680	76763680	+	3'UTR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76763680delA	uc004ecp.3	-	35					ATRX_uc004ecq.3_3'UTR|ATRX_uc004eco.3_3'UTR	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
ATRX	546	broad.mit.edu	37	X	76814401	76814402	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76814401_76814402insT	uc004ecp.3	-						ATRX_uc004ecq.3_Intron|ATRX_uc004eco.3_Intron	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
HMGN5	79366	broad.mit.edu	37	X	80373886	80373886	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:80373886delA	uc004eee.1	-							NM_030763	NP_110390			high-mobility group nucleosome binding domain 5						chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|nucleolus	chromatin binding|DNA binding			lung(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	81762218	81762218	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:81762218delT								None (None upstream) : None (None downstream)																																			---	---	---	---
RPS6KA6	27330	broad.mit.edu	37	X	83361836	83361836	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83361836delA	uc004eej.1	-						RPS6KA6_uc011mqt.1_Intron|RPS6KA6_uc011mqu.1_Intron	NM_014496	NP_055311			ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
RPS6KA6	27330	broad.mit.edu	37	X	83403063	83403063	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83403063delT	uc004eej.1	-	4	404	c.327delA	c.(325-327)AAAfs	p.K109fs	RPS6KA6_uc011mqt.1_Frame_Shift_Del_p.K109fs|RPS6KA6_uc011mqu.1_Frame_Shift_Del_p.K6fs|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	109	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
ZNF711	7552	broad.mit.edu	37	X	84524996	84524996	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84524996delT	uc004eeo.2	+						ZNF711_uc004eep.2_Intron|ZNF711_uc004eeq.2_Intron|ZNF711_uc011mqy.1_Intron	NM_021998	NP_068838			zinc finger protein 711						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
CHM	1121	broad.mit.edu	37	X	85134074	85134074	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85134074delA	uc004eet.2	-						CHM_uc011mqz.1_Intron	NM_000390	NP_000381			choroideremia isoform a						intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)																---	---	---	---
CHM	1121	broad.mit.edu	37	X	85211082	85211082	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85211082delT	uc004eet.2	-						CHM_uc011mqz.1_Intron	NM_000390	NP_000381			choroideremia isoform a						intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)																---	---	---	---
CSTF2	1478	broad.mit.edu	37	X	100093046	100093046	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100093046delT	uc004egh.2	+						CSTF2_uc010nnd.2_Intron|CSTF2_uc004egi.2_Intron	NM_001325	NP_001316			cleavage stimulation factor subunit 2						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1																		---	---	---	---
CENPI	2491	broad.mit.edu	37	X	100387613	100387613	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100387613delT	uc004egx.2	+						CENPI_uc011mrg.1_Intron|CENPI_uc004egy.2_Intron	NM_006733	NP_006724			centromere protein I						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1																		---	---	---	---
CENPI	2491	broad.mit.edu	37	X	100401470	100401470	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100401470delA	uc004egx.2	+						CENPI_uc011mrg.1_Intron	NM_006733	NP_006724			centromere protein I						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1																		---	---	---	---
DRP2	1821	broad.mit.edu	37	X	100492543	100492543	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100492543delA	uc004egz.2	+						DRP2_uc011mrh.1_Intron	NM_001939	NP_001930			dystrophin related protein 2						central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2																		---	---	---	---
TAF7L	54457	broad.mit.edu	37	X	100532440	100532444	+	Intron	DEL	AAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100532440_100532444delAAAAA	uc004ehb.2	-						TAF7L_uc004eha.2_Intron|TAF7L_uc004ehc.1_Intron	NM_024885	NP_079161			TATA box binding protein-associated factor, RNA						cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1																		---	---	---	---
TAF7L	54457	broad.mit.edu	37	X	100538467	100538467	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100538467delT	uc004ehb.2	-	4	520	c.508delA	c.(508-510)ACCfs	p.T170fs	TAF7L_uc004eha.2_Frame_Shift_Del_p.T84fs|TAF7L_uc004ehc.1_Frame_Shift_Del_p.T84fs	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	170					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1																		---	---	---	---
RAB9B	51209	broad.mit.edu	37	X	103079927	103079928	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103079927_103079928delTT	uc004eli.1	-											Homo sapiens mRNA for RAB9-like protein, complete cds.						Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			lung(3)	3																		---	---	---	---
TBC1D8B	54885	broad.mit.edu	37	X	106108892	106108892	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106108892delT	uc004emo.2	+						MORC4_uc004emp.3_Intron	NM_017752	NP_060222			TBC1 domain family, member 8B (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
CXorf41	139212	broad.mit.edu	37	X	106461964	106461964	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106461964delA	uc004enc.2	+						CXorf41_uc004end.2_Intron	NM_173494	NP_775765			hypothetical protein LOC139212												0																		---	---	---	---
CHRDL1	91851	broad.mit.edu	37	X	110035534	110035535	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110035534_110035535delAA	uc004eou.3	-						CHRDL1_uc004eov.2_5'Flank|CHRDL1_uc004eow.2_Intron|CHRDL1_uc010nps.2_Intron|CHRDL1_uc004eot.2_Intron|CHRDL1_uc011mss.1_Intron|CHRDL1_uc004eox.3_Intron	NM_001143981	NP_001137453			chordin-like 1 isoform 1 precursor						BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0																		---	---	---	---
CAPN6	827	broad.mit.edu	37	X	110506864	110506864	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110506864delA	uc004epc.1	-						CAPN6_uc011msu.1_Intron	NM_014289	NP_055104			calpain 6						microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	110862948	110862949	+	IGR	DEL	AG	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:110862948_110862949delAG								DCX (207542 upstream) : ALG13 (61464 downstream)																																			---	---	---	---
AMOT	154796	broad.mit.edu	37	X	112023977	112023978	+	Intron	INS	-	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:112023977_112023978insA	uc004eps.2	-						AMOT_uc004epr.2_Intron|AMOT_uc011mtc.1_Intron|hsa-mir-4329|MI0015901_RNA	NM_133265	NP_573572			angiomotin isoform 2						actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1																		---	---	---	---
PLS3	5358	broad.mit.edu	37	X	114877477	114877477	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114877477delT	uc004eqd.2	+						PLS3_uc010nqg.2_Intron|PLS3_uc011mtf.1_Intron|PLS3_uc004eqe.2_Intron|PLS3_uc011mtg.1_Intron|PLS3_uc011mth.1_Intron|PLS3_uc011mti.1_Intron|PLS3_uc011mtj.1_Intron|PLS3_uc011mtk.1_5'Flank|PLS3_uc011mtl.1_5'Flank	NM_005032	NP_005023			plastin 3							cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2																		---	---	---	---
AGTR2	186	broad.mit.edu	37	X	115303402	115303402	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115303402delT	uc004eqh.3	+							NM_000686	NP_000677			angiotensin II receptor, type 2						behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			ovary(2)|lung(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	115823005	115823005	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115823005delT								CXorf61 (228868 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	115826808	115826808	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:115826808delT								CXorf61 (232671 upstream) : None (None downstream)																																			---	---	---	---
KLHL13	90293	broad.mit.edu	37	X	117079260	117079260	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117079260delA	uc004eql.2	-						KLHL13_uc004eqk.2_Intron|KLHL13_uc011mtn.1_Intron|KLHL13_uc011mto.1_Intron|KLHL13_uc011mtp.1_Intron|KLHL13_uc004eqm.2_Intron|KLHL13_uc011mtq.1_Intron	NM_033495	NP_277030			kelch-like 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2																		---	---	---	---
IL13RA1	3597	broad.mit.edu	37	X	117907665	117907665	+	Intron	DEL	T	-	-	rs3838204		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117907665delT	uc004eqs.2	+						IL13RA1_uc004eqt.1_Intron	NM_001560	NP_001551			interleukin 13 receptor, alpha 1 precursor							interleukin-13 receptor complex	cytokine receptor activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	118012394	118012394	+	IGR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118012394delT								ZCCHC12 (51464 upstream) : LONRF3 (96319 downstream)																																			---	---	---	---
CXorf56	63932	broad.mit.edu	37	X	118694020	118694021	+	Intron	DEL	AA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118694020_118694021delAA	uc004erk.1	-						CXorf56_uc004erj.1_Intron|CXorf56_uc011mtu.1_Intron	NM_022101	NP_071384			hypothetical protein LOC63932								protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	118946216	118946216	+	IGR	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118946216delA								RPL39 (20610 upstream) : UPF3B (21773 downstream)																																			---	---	---	---
CUL4B	8450	broad.mit.edu	37	X	119674486	119674487	+	Intron	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119674486_119674487insT	uc004esw.2	-						CUL4B_uc010nqq.2_Intron|CUL4B_uc004esv.2_Intron	NM_003588	NP_003579			cullin 4B isoform 1						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CUL4B	8450	broad.mit.edu	37	X	119678281	119678281	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119678281delA	uc004esw.2	-						CUL4B_uc010nqq.2_Intron|CUL4B_uc004esv.2_Intron	NM_003588	NP_003579			cullin 4B isoform 1						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CUL4B	8450	broad.mit.edu	37	X	119695297	119695297	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119695297delG	uc004esw.2	-						CUL4B_uc004esv.2_5'Flank	NM_003588	NP_003579			cullin 4B isoform 1						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
MCTS1	28985	broad.mit.edu	37	X	119739116	119739116	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119739116delT	uc004esx.2	+						MCTS1_uc011mub.1_Intron	NM_014060	NP_054779			malignant T cell amplified sequence 1 isoform 1						cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0																		---	---	---	---
RBMX2	51634	broad.mit.edu	37	X	129543182	129543182	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129543182delT	uc004evt.2	+							NM_016024	NP_057108			RNA binding motif protein, X-linked 2								nucleotide binding|RNA binding			breast(3)|ovary(1)	4																		---	---	---	---
ENOX2	10495	broad.mit.edu	37	X	129790756	129790756	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129790756delT	uc004evw.2	-						ENOX2_uc004evx.2_Intron|ENOX2_uc004evy.2_Intron|ENOX2_uc004evv.2_Intron	NM_182314	NP_872114			ecto-NOX disulfide-thiol exchanger 2 isoform b						cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1																		---	---	---	---
ENOX2	10495	broad.mit.edu	37	X	129804249	129804250	+	Intron	DEL	AG	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129804249_129804250delAG	uc004evw.2	-						ENOX2_uc004evx.2_Intron|ENOX2_uc004evy.2_Intron|ENOX2_uc004evv.2_Intron	NM_182314	NP_872114			ecto-NOX disulfide-thiol exchanger 2 isoform b						cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1																		---	---	---	---
IGSF1	3547	broad.mit.edu	37	X	130416297	130416298	+	Intron	INS	-	TG	TG	rs5001888		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:130416297_130416298insTG	uc004ewd.2	-						IGSF1_uc004ewe.3_Intron|IGSF1_uc004ewf.2_Intron	NM_001555	NP_001546			immunoglobulin superfamily, member 1 isoform 1						regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5																		---	---	---	---
GPC3	2719	broad.mit.edu	37	X	132796035	132796035	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:132796035delA	uc004exe.1	-						GPC3_uc004exd.1_Intron|GPC3_uc010nrn.1_Intron|GPC3_uc011mvh.1_Intron|GPC3_uc010nro.1_Intron	NM_004484	NP_004475			glypican 3 isoform 2 precursor							extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)							T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				---	---	---	---
FAM122B	159090	broad.mit.edu	37	X	133915842	133915842	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133915842delT	uc004exr.2	-						FAM122B_uc004exq.2_Intron|FAM122B_uc004exs.2_Intron|FAM122B_uc004ext.2_Intron|FAM122B_uc004exu.2_Intron|FAM122B_uc011mvp.1_Intron|FAM122B_uc004exv.2_Intron	NM_145284	NP_660327			hypothetical protein LOC159090												0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
FAM122C	159091	broad.mit.edu	37	X	133963451	133963452	+	Intron	INS	-	A	A	rs72454255		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133963451_133963452insA	uc004exz.1	+						FAM122C_uc011mvq.1_Intron|FAM122C_uc004exy.1_Intron	NM_138819	NP_620174			hypothetical protein LOC159091												0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ZNF75D	7626	broad.mit.edu	37	X	134421687	134421688	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134421687_134421688insT	uc004eyp.2	-	7	3569_3570	c.914_915insA	c.(913-915)AAGfs	p.K305fs	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Frame_Shift_Ins_p.K84fs|ZNF75D_uc004eyo.2_Frame_Shift_Ins_p.K210fs	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	305	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ZNF449	203523	broad.mit.edu	37	X	134493962	134493962	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134493962delA	uc004eys.2	+						ZNF449_uc004eyt.2_Intron|ZNF449_uc004eyu.2_Intron	NM_152695	NP_689908			zinc finger protein 449						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MMGT1	93380	broad.mit.edu	37	X	135047055	135047055	+	3'UTR	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135047055delT	uc004ezi.1	-	4					MMGT1_uc011mvw.1_3'UTR	NM_173470	NP_775741			membrane magnesium transporter 1 precursor							early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0																		---	---	---	---
MAP7D3	79649	broad.mit.edu	37	X	135322790	135322790	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135322790delT	uc004ezt.2	-						MAP7D3_uc004ezs.2_Intron|MAP7D3_uc011mwc.1_Intron|MAP7D3_uc010nsa.1_Intron	NM_024597	NP_078873			MAP7 domain containing 3							cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
GPR112	139378	broad.mit.edu	37	X	135477759	135477759	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135477759delT	uc004ezu.1	+						GPR112_uc010nsb.1_Intron	NM_153834	NP_722576			G-protein coupled receptor 112						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MCF2	4168	broad.mit.edu	37	X	138708237	138708237	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138708237delT	uc004fau.2	-						MCF2_uc004fav.2_Intron|MCF2_uc011mwl.1_Intron|MCF2_uc010nsh.1_Intron|MCF2_uc011mwm.1_Intron|MCF2_uc011mwn.1_Intron|MCF2_uc004faw.2_Intron|MCF2_uc011mwo.1_Intron	NM_005369	NP_005360			MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ATP11C	286410	broad.mit.edu	37	X	138865164	138865164	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138865164delA	uc004faz.2	-						ATP11C_uc004fay.2_Intron|ATP11C_uc004fba.2_Intron	NM_173694	NP_775965			ATPase, class VI, type 11C isoform a						ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
FMR1NB	158521	broad.mit.edu	37	X	147106625	147106625	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147106625delT	uc004fcm.2	+							NM_152578	NP_689791			fragile X mental retardation 1 neighbor							integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MTM1	4534	broad.mit.edu	37	X	149783252	149783252	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:149783252delA	uc004fef.3	+						MTM1_uc011mxx.1_Intron|MTM1_uc011mxy.1_Intron|MTM1_uc011mxz.1_Intron|MTM1_uc010nte.2_Intron	NM_000252	NP_000243			myotubularin						endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MTM1	4534	broad.mit.edu	37	X	149832228	149832228	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:149832228delT	uc004fef.3	+						MTM1_uc011mxx.1_Intron|MTM1_uc011mxy.1_Intron|MTM1_uc011mxz.1_Intron|MTM1_uc010nte.2_Intron	NM_000252	NP_000243			myotubularin						endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MTMR1	8776	broad.mit.edu	37	X	149898488	149898488	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:149898488delA	uc004fei.2	+						MTMR1_uc011mya.1_Intron|MTMR1_uc004feg.1_Intron|MTMR1_uc004feh.1_Intron|MTMR1_uc004fej.2_Intron|MTMR1_uc010ntf.2_Intron	NM_003828	NP_003819			myotubularin-related protein 1							plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MTMR1	8776	broad.mit.edu	37	X	149898766	149898767	+	Intron	DEL	TT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:149898766_149898767delTT	uc004fei.2	+						MTMR1_uc011mya.1_Intron|MTMR1_uc004feg.1_Intron|MTMR1_uc004feh.1_Intron|MTMR1_uc004fej.2_Intron|MTMR1_uc010ntf.2_Intron	NM_003828	NP_003819			myotubularin-related protein 1							plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
VMA21	203547	broad.mit.edu	37	X	150573370	150573370	+	Intron	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150573370delT	uc004feu.2	+							NM_001017980	NP_001017980			VMA21 vacuolar H+-ATPase homolog						vacuolar proton-transporting V-type ATPase complex assembly	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane|lysosome					0																		---	---	---	---
GABRQ	55879	broad.mit.edu	37	X	151819112	151819112	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151819112delA	uc004ffp.1	+							NM_018558	NP_061028			gamma-aminobutyric acid (GABA) receptor, theta							cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GABRQ	55879	broad.mit.edu	37	X	151821062	151821062	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151821062delC	uc004ffp.1	+	9	1237	c.1217delC	c.(1216-1218)GCCfs	p.A406fs		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	406						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
SLC6A8	6535	broad.mit.edu	37	X	152957363	152957363	+	Intron	DEL	G	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152957363delG	uc004fib.3	+						SLC6A8_uc004fic.3_Intron|SLC6A8_uc011myx.1_Intron|SLC6A8_uc010nuj.2_5'Flank|SLC6A8_uc010nui.1_Intron	NM_005629	NP_005620			solute carrier family 6 member 8 isoform 1						creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)													---	---	---	---
TMEM187	8269	broad.mit.edu	37	X	153247940	153247941	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153247940_153247941delCT	uc004fjq.2	+	2	961_962	c.427_428delCT	c.(427-429)CTCfs	p.L143fs	hsa-mir-3202-2|MI0014253_5'Flank	NM_003492	NP_003483	Q14656	TM187_HUMAN	transmembrane protein 187	143	Helical; (Potential).					integral to membrane|transport vesicle					0	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
G6PD	2539	broad.mit.edu	37	X	153774052	153774060	+	Intron	DEL	AAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153774052_153774060delAAAAAAAAA	uc004fly.1	-						G6PD_uc004flx.1_Intron|IKBKG_uc011mzr.1_Intron|IKBKG_uc010nva.2_5'Flank|IKBKG_uc004fmb.3_5'Flank|IKBKG_uc011mzs.1_5'Flank|IKBKG_uc004fma.3_5'Flank|IKBKG_uc004fmc.3_5'Flank|IKBKG_uc004fmd.2_5'Flank	NM_001042351	NP_001035810			glucose-6-phosphate dehydrogenase isoform b						cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
DKC1	1736	broad.mit.edu	37	X	153997269	153997280	+	Intron	DEL	AAAAAAAAAAAA	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153997269_153997280delAAAAAAAAAAAA	uc004fmm.2	+						DKC1_uc010nvf.2_Intron	NM_001363	NP_001354			dyskerin isoform 1						cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)													Congenital_Dyskeratosis				---	---	---	---
H2AFB1	474382	broad.mit.edu	37	X	154113626	154113626	+	Frame_Shift_Del	DEL	T	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154113626delT	uc004fmu.2	+	1	310	c.302delT	c.(301-303)CTTfs	p.L101fs	F8_uc004fmt.2_Intron|F8_uc004fms.2_Intron|F8A1_uc004fmv.2_5'Flank	NM_080720	NP_542451	P0C5Y9	H2AB1_HUMAN	H2A histone family, member B3	101	Docking domain.				nucleosome assembly	nucleosome|nucleus	DNA binding				0	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
MTCP1	4515	broad.mit.edu	37	X	154293679	154293679	+	Intron	DEL	A	-	-			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154293679delA	uc004fmz.2	-						MTCP1NB_uc004fmy.2_Intron	NM_001018025	NP_001018025			mature T-cell proliferation 1						cell proliferation					lung(1)	1	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)							T	TRA@	T cell prolymphocytic leukemia								---	---	---	---
AGRN	375790	broad.mit.edu	37	1	979559	979559	+	Silent	SNP	C	T	T	rs146441147		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:979559C>T	uc001ack.1	+	11	2120	c.2070C>T	c.(2068-2070)CGC>CGT	p.R690R		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	690					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)														---	---	---	---
GLTPD1	80772	broad.mit.edu	37	1	1262961	1262961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1262961C>T	uc001aeo.2	+	3	878	c.463C>T	c.(463-465)CGC>TGC	p.R155C	CPSF3L_uc001aee.1_5'Flank|CPSF3L_uc001aef.1_5'Flank|CPSF3L_uc009vjz.1_5'Flank|CPSF3L_uc010nyj.1_5'Flank|CPSF3L_uc001aeg.1_5'Flank|CPSF3L_uc001aeh.1_5'Flank|CPSF3L_uc001aei.1_5'Flank|CPSF3L_uc001aej.1_5'Flank|CPSF3L_uc001aek.1_5'Flank|CPSF3L_uc001aem.1_5'Flank|CPSF3L_uc001ael.1_5'Flank|CPSF3L_uc001aen.1_5'Flank	NM_001029885	NP_001025056	Q5TA50	GLTD1_HUMAN	glycolipid transfer protein domain containing 1	155						cytoplasm	glycolipid binding|glycolipid transporter activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
TAS1R3	83756	broad.mit.edu	37	1	1269515	1269515	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1269515T>G	uc010nyk.1	+	6	2230	c.2230T>G	c.(2230-2232)TGC>GGC	p.C744G		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	744	Helical; Name=5; (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)													---	---	---	---
DVL1	1855	broad.mit.edu	37	1	1275137	1275137	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1275137C>T	uc001aer.3	-	9	1012	c.965G>A	c.(964-966)CGG>CAG	p.R322Q	DVL1_uc002quu.2_Missense_Mutation_p.R39Q|DVL1_uc009vka.2_5'UTR|DVL1_uc001aeu.1_Missense_Mutation_p.G9R	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	322	PDZ.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)														---	---	---	---
CDK11B	984	broad.mit.edu	37	1	1575796	1575796	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1575796C>T	uc001agv.1	-	15	1204	c.1093G>A	c.(1093-1095)GAC>AAC	p.D365N	CDK11B_uc009vkj.2_Missense_Mutation_p.D22N|CDK11B_uc001ags.1_Missense_Mutation_p.D223N|CDK11B_uc001agt.1_Missense_Mutation_p.D148N|CDK11B_uc001aha.1_Missense_Mutation_p.D331N|CDK11B_uc001agw.1_Missense_Mutation_p.D320N|CDK11B_uc001agy.1_Missense_Mutation_p.D363N|CDK11B_uc001agx.1_Missense_Mutation_p.D354N|CDK11B_uc001agz.1_Missense_Mutation_p.D109N	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	378	Glu-rich.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1																		---	---	---	---
PRKCZ	5590	broad.mit.edu	37	1	1987008	1987008	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1987008C>A	uc001aiq.2	+							NM_002744	NP_002735			protein kinase C, zeta isoform 1						anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)														---	---	---	---
PRKCZ	5590	broad.mit.edu	37	1	2103633	2103633	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2103633C>T	uc001aiq.2	+						PRKCZ_uc001air.2_Intron|PRKCZ_uc010nyw.1_Intron|PRKCZ_uc001ais.2_Intron|PRKCZ_uc009vla.2_Intron|PRKCZ_uc010nyx.1_Intron|PRKCZ_uc001ait.2_Intron	NM_002744	NP_002735			protein kinase C, zeta isoform 1						anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)														---	---	---	---
C1orf86	199990	broad.mit.edu	37	1	2125140	2125140	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2125140C>T	uc001aiy.2	-	3	434	c.408G>A	c.(406-408)CCG>CCA	p.P136P	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Missense_Mutation_p.R132H	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	136											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)														---	---	---	---
PEX10	5192	broad.mit.edu	37	1	2337210	2337210	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2337210G>A	uc001ajh.2	-	6	1045	c.976C>T	c.(976-978)CGC>TGC	p.R326C	PEX10_uc001ajg.2_Missense_Mutation_p.R346C	NM_002617	NP_002608	O60683	PEX10_HUMAN	peroxisome biogenesis factor 10 isoform 2	326					protein import into peroxisome matrix|protein import into peroxisome matrix	integral to peroxisomal membrane|peroxisomal membrane	protein binding|protein C-terminus binding|zinc ion binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00102)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0169)|Lung(427;0.199)														---	---	---	---
PANK4	55229	broad.mit.edu	37	1	2450576	2450576	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2450576C>T	uc001ajm.1	-						PANK4_uc010nza.1_Intron	NM_018216	NP_060686			pantothenate kinase 4						coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)														---	---	---	---
PRDM16	63976	broad.mit.edu	37	1	3342703	3342703	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3342703C>T	uc001akf.2	+	14	3278	c.3198C>T	c.(3196-3198)GAC>GAT	p.D1066D	PRDM16_uc001akc.2_Silent_p.D1065D|PRDM16_uc001akd.2_Silent_p.D1065D|PRDM16_uc001ake.2_Silent_p.D1066D|PRDM16_uc009vlh.2_Silent_p.D766D	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	1066	Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)				T	EVI1	MDS|AML								---	---	---	---
MEGF6	1953	broad.mit.edu	37	1	3417557	3417557	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3417557C>T	uc001akl.2	-	20	2775	c.2548G>A	c.(2548-2550)GGG>AGG	p.G850R	MEGF6_uc001akk.2_Missense_Mutation_p.G745R	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	850	EGF-like 14.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)														---	---	---	---
MEGF6	1953	broad.mit.edu	37	1	3425206	3425206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3425206C>T	uc001akl.2	-	13	1803	c.1576G>A	c.(1576-1578)GAC>AAC	p.D526N	MEGF6_uc001akk.2_Missense_Mutation_p.D421N	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	526	EGF-like 9.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)														---	---	---	---
TPRG1L	127262	broad.mit.edu	37	1	3544202	3544202	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3544202A>G	uc001akm.2	+	4	690	c.609A>G	c.(607-609)ACA>ACG	p.T203T	TPRG1L_uc009vlj.2_Silent_p.T144T	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	203						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)														---	---	---	---
CCDC27	148870	broad.mit.edu	37	1	3679950	3679950	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3679950G>A	uc001akv.2	+	7	1314	c.1233G>A	c.(1231-1233)CTG>CTA	p.L411L		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	411	Glu-rich.									skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)														---	---	---	---
C1orf174	339448	broad.mit.edu	37	1	3809519	3809519	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3809519T>C	uc001alf.2	-	2	164	c.57A>G	c.(55-57)CGA>CGG	p.R19R	C1orf174_uc009vls.2_RNA	NM_207356	NP_997239	Q8IYL3	CA174_HUMAN	hypothetical protein LOC339448	19											0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;5.09e-25)|all_epithelial(116;9.35e-17)|all_lung(118;1.09e-06)|Lung NSC(185;0.000139)|all_neural(13;0.00287)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0219)|all_hematologic(16;0.027)|Colorectal(325;0.0276)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;1.55e-39)|OV - Ovarian serous cystadenocarcinoma(86;5.99e-23)|GBM - Glioblastoma multiforme(42;2.22e-17)|Colorectal(212;1.08e-05)|COAD - Colon adenocarcinoma(227;5.49e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000365)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.19)														---	---	---	---
AJAP1	55966	broad.mit.edu	37	1	4834505	4834505	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:4834505G>A	uc001alm.1	+	5	1563	c.1182G>A	c.(1180-1182)CGG>CGA	p.R394R	AJAP1_uc001aln.2_Silent_p.R394R	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	394	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)														---	---	---	---
CHD5	26038	broad.mit.edu	37	1	6204099	6204099	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6204099G>A	uc001amb.1	-	12	2019	c.1919C>T	c.(1918-1920)GCC>GTC	p.A640V	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	640	Chromo 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)														---	---	---	---
CHD5	26038	broad.mit.edu	37	1	6212526	6212526	+	Silent	SNP	G	A	A	rs140463225	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6212526G>A	uc001amb.1	-	6	916	c.816C>T	c.(814-816)GCC>GCT	p.A272A		NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	272	Lys-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)														---	---	---	---
GPR153	387509	broad.mit.edu	37	1	6313900	6313900	+	Missense_Mutation	SNP	C	T	T	rs141201270	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6313900C>T	uc001amp.1	-	3	924	c.664G>A	c.(664-666)GCG>ACG	p.A222T		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	222	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)														---	---	---	---
ACOT7	11332	broad.mit.edu	37	1	6399491	6399491	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6399491A>G	uc001ams.2	-	3	605	c.448_splice	c.e3+1	p.G150_splice	ACOT7_uc010nzq.1_Splice_Site_p.G35_splice|ACOT7_uc001amt.2_Splice_Site_p.G140_splice|ACOT7_uc001amu.2_Splice_Site|ACOT7_uc001amv.2_Splice_Site|ACOT7_uc001amq.2_Splice_Site_p.G99_splice|ACOT7_uc001amr.2_Splice_Site_p.G120_splice	NM_181864	NP_863654			acyl-CoA thioesterase 7 isoform hBACHb							mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)														---	---	---	---
TNFRSF25	8718	broad.mit.edu	37	1	6524767	6524767	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6524767G>A	uc001ane.2	-	4	396	c.308C>T	c.(307-309)GCG>GTG	p.A103V	TNFRSF25_uc001ana.2_Intron|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_5'UTR|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.A103V|TNFRSF25_uc001ang.2_Missense_Mutation_p.A58V|TNFRSF25_uc001anh.2_Missense_Mutation_p.A103V|TNFRSF25_uc001ani.1_Missense_Mutation_p.A103V	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	103	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity	p.A103A(1)		central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
PLEKHG5	57449	broad.mit.edu	37	1	6579499	6579499	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6579499A>G	uc001anp.1	-						PLEKHG5_uc001anq.1_Intron	NM_198681	NP_941374			pleckstrin homology domain containing family G						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
TAS1R1	80835	broad.mit.edu	37	1	6631009	6631009	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6631009G>A	uc001ant.2	+	2	232	c.232G>A	c.(232-234)GCT>ACT	p.A78T	TAS1R1_uc001anu.2_Missense_Mutation_p.A78T|TAS1R1_uc001anv.2_Missense_Mutation_p.A78T|TAS1R1_uc001anw.2_Missense_Mutation_p.A78T	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	78	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
KLHL21	9903	broad.mit.edu	37	1	6659354	6659354	+	Missense_Mutation	SNP	G	A	A	rs141248147		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6659354G>A	uc001aoa.2	-	2	1232	c.1180C>T	c.(1180-1182)CGC>TGC	p.R394C	KLHL21_uc001anz.1_Missense_Mutation_p.R394C|KLHL21_uc009vme.2_Missense_Mutation_p.R27C	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	394	Kelch 3.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)														---	---	---	---
PHF13	148479	broad.mit.edu	37	1	6679933	6679933	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6679933A>G	uc001aob.3	+	3	583	c.212A>G	c.(211-213)GAC>GGC	p.D71G		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	71					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
PER3	8863	broad.mit.edu	37	1	7890044	7890044	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7890044A>G	uc001aoo.2	+	18	3185	c.3010A>G	c.(3010-3012)ACT>GCT	p.T1004A	PER3_uc009vmg.1_Missense_Mutation_p.T1012A|PER3_uc009vmh.1_Missense_Mutation_p.T1005A|PER3_uc001aop.2_Missense_Mutation_p.T1013A|PER3_uc010nzw.1_Missense_Mutation_p.T693A	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1004	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
ERRFI1	54206	broad.mit.edu	37	1	8073280	8073280	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8073280A>G	uc001aoz.2	-	4	1628	c.1379T>C	c.(1378-1380)GTT>GCT	p.V460A		NM_018948	NP_061821	Q9UJM3	ERRFI_HUMAN	mitogen-inducible gene 6 protein	460					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			ovary(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
SLC45A1	50651	broad.mit.edu	37	1	8397983	8397983	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8397983T>C	uc001apb.2	+	6	1705	c.1705T>C	c.(1705-1707)TAC>CAC	p.Y569H	SLC45A1_uc001apc.2_Missense_Mutation_p.Y267H	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	569					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CA6	765	broad.mit.edu	37	1	9005977	9005977	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9005977T>C	uc001apm.2	+	1	56	c.32T>C	c.(31-33)TTC>TCC	p.F11S	CA6_uc009vmn.2_Missense_Mutation_p.F11S	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	11					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
H6PD	9563	broad.mit.edu	37	1	9305622	9305622	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9305622T>C	uc001apt.2	+	2	900	c.627_splice	c.e2+2	p.Q209_splice		NM_004285	NP_004276			hexose-6-phosphate dehydrogenase precursor							endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)													---	---	---	---
TMEM201	199953	broad.mit.edu	37	1	9661349	9661349	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9661349A>G	uc001apz.2	+	5	805	c.793A>G	c.(793-795)ACC>GCC	p.T265A	TMEM201_uc001apy.2_Missense_Mutation_p.T265A	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1	265						integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
RBP7	116362	broad.mit.edu	37	1	10067724	10067724	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10067724G>A	uc001aqq.2	+	2	232	c.170G>A	c.(169-171)AGC>AAC	p.S57N	RBP7_uc009vms.2_RNA	NM_052960	NP_443192	Q96R05	RET7_HUMAN	retinol binding protein 7, cellular	57						cytoplasm	retinal binding|retinol binding|transporter activity				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|BRCA - Breast invasive adenocarcinoma(304;0.000302)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00856)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)													---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10381867	10381867	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10381867C>T	uc001aqx.3	+	24	2512	c.2310C>T	c.(2308-2310)GCC>GCT	p.A770A	KIF1B_uc001aqw.3_Silent_p.A724A|KIF1B_uc001aqy.2_Silent_p.A744A|KIF1B_uc001aqz.2_Silent_p.A770A|KIF1B_uc001ara.2_Silent_p.A730A|KIF1B_uc001arb.2_Silent_p.A756A	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	770					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10384880	10384880	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10384880G>T	uc001aqx.3	+	26	2804	c.2602G>T	c.(2602-2604)GAC>TAC	p.D868Y	KIF1B_uc001aqw.3_Missense_Mutation_p.D822Y|KIF1B_uc001aqy.2_Missense_Mutation_p.D842Y|KIF1B_uc001aqz.2_Missense_Mutation_p.D868Y|KIF1B_uc001ara.2_Missense_Mutation_p.D828Y|KIF1B_uc001arb.2_Missense_Mutation_p.D854Y	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	868	Potential.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
KIF1B	23095	broad.mit.edu	37	1	10425306	10425306	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10425306A>G	uc001aqx.3	+						KIF1B_uc001aqw.3_Intron|KIF1B_uc001aqy.2_Intron|KIF1B_uc001aqz.2_Intron|KIF1B_uc001ara.2_Intron|KIF1B_uc001arb.2_Intron	NM_015074	NP_055889			kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
PGD	5226	broad.mit.edu	37	1	10460487	10460487	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10460487A>C	uc001arc.2	+	3	212	c.122A>C	c.(121-123)GAT>GCT	p.D41A	PGD_uc001ard.2_5'UTR|PGD_uc010oak.1_Missense_Mutation_p.D41A|PGD_uc010oal.1_Missense_Mutation_p.D28A	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	41					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
TARDBP	23435	broad.mit.edu	37	1	11078874	11078874	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11078874T>C	uc001art.2	+	4	621	c.487T>C	c.(487-489)TCA>CCA	p.S163P	TARDBP_uc010oap.1_Missense_Mutation_p.S47P	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	163	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
EXOSC10	5394	broad.mit.edu	37	1	11131025	11131025	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11131025G>A	uc001asa.2	-	21	2298	c.2248C>T	c.(2248-2250)CGG>TGG	p.R750W	EXOSC10_uc001asb.2_Missense_Mutation_p.R725W	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	750					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)														---	---	---	---
EXOSC10	5394	broad.mit.edu	37	1	11142796	11142796	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11142796T>C	uc001asa.2	-	10	1279	c.1229A>G	c.(1228-1230)TAC>TGC	p.Y410C	EXOSC10_uc001asb.2_Missense_Mutation_p.Y410C|EXOSC10_uc009vmy.1_Missense_Mutation_p.Y410C	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	410					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)														---	---	---	---
MTOR	2475	broad.mit.edu	37	1	11288788	11288788	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11288788G>A	uc001asd.2	-	19	3088	c.2967C>T	c.(2965-2967)TTC>TTT	p.F989F		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	989	HEAT 4.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29																		---	---	---	---
UBIAD1	29914	broad.mit.edu	37	1	11333988	11333988	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11333988T>C	uc001asg.2	+	1	734	c.400T>C	c.(400-402)TTC>CTC	p.F134L		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	134	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)														---	---	---	---
PTCHD2	57540	broad.mit.edu	37	1	11580770	11580770	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11580770T>C	uc001ash.3	+	10	2365	c.2227T>C	c.(2227-2229)TCC>CCC	p.S743P	PTCHD2_uc001asi.1_Missense_Mutation_p.S743P	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	743	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)														---	---	---	---
PTCHD2	57540	broad.mit.edu	37	1	11586864	11586864	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11586864G>A	uc001ash.3	+	13	2908	c.2770G>A	c.(2770-2772)GTG>ATG	p.V924M	PTCHD2_uc001asi.1_Missense_Mutation_p.V924M	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	924	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)														---	---	---	---
FBXO44	93611	broad.mit.edu	37	1	11721370	11721370	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11721370A>G	uc001asm.2	+	6					FBXO44_uc001ask.2_3'UTR|FBXO44_uc001asl.2_3'UTR|FBXO44_uc001asn.2_3'UTR|FBXO44_uc010oar.1_3'UTR|FBXO44_uc010oas.1_3'UTR|FBXO6_uc001aso.2_5'Flank	NM_033182	NP_149438			F-box protein 44 isoform 1						protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PLOD1	5351	broad.mit.edu	37	1	12034725	12034725	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12034725T>C	uc001atm.2	+	19	2135	c.2044T>C	c.(2044-2046)TTC>CTC	p.F682L	PLOD1_uc010obb.1_Missense_Mutation_p.F729L	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	682	Fe2OG dioxygenase.				epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
MFN2	9927	broad.mit.edu	37	1	12057394	12057394	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12057394A>G	uc001atn.3	+	6	968	c.515A>G	c.(514-516)CAG>CGG	p.Q172R	MFN2_uc009vni.2_Missense_Mutation_p.Q172R	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	172	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)														---	---	---	---
MFN2	9927	broad.mit.edu	37	1	12065963	12065963	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12065963G>A	uc001atn.3	+	15	2144	c.1691G>A	c.(1690-1692)CGG>CAG	p.R564Q	MFN2_uc009vni.2_Missense_Mutation_p.R564Q	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	564	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding	p.R564W(1)		ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)														---	---	---	---
TNFRSF1B	7133	broad.mit.edu	37	1	12248947	12248947	+	Missense_Mutation	SNP	C	T	T	rs139221787		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12248947C>T	uc001att.2	+	2	262	c.173C>T	c.(172-174)TCG>TTG	p.S58L	TNFRSF1B_uc001atu.2_Intron|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	58	Extracellular (Potential).|TNFR-Cys 1.				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)													---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12336565	12336565	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12336565T>C	uc001atv.2	+	19	3061	c.2920T>C	c.(2920-2922)TAC>CAC	p.Y974H	VPS13D_uc001atw.2_Missense_Mutation_p.Y974H|VPS13D_uc001atx.2_Missense_Mutation_p.Y162H	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	974					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)												OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PRAMEF1	65121	broad.mit.edu	37	1	12856081	12856081	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12856081C>A	uc001auj.1	+	4	1464	c.1361C>A	c.(1360-1362)CCC>CAC	p.P454H		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	454											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF8	391002	broad.mit.edu	37	1	12980059	12980059	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12980059T>C	uc001aup.2	+	4	1334	c.1251T>C	c.(1249-1251)AGT>AGC	p.S417S		NM_001012276	NP_001012276	Q5VWM4	PRAM8_HUMAN	PRAME family member 8	417											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF16	654348	broad.mit.edu	37	1	13497743	13497743	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13497743T>C	uc001aux.2	+	3	1070	c.1040T>C	c.(1039-1041)GTT>GCT	p.V347A		NM_001045480	NP_001038945	Q5VWM1	PRA16_HUMAN	PRAME family member 16	347											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CELA2B	51032	broad.mit.edu	37	1	15817807	15817807	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15817807A>G	uc001awl.2	+	8	835	c.810A>G	c.(808-810)TAA>TAG	p.*270*	CASP9_uc001awm.1_3'UTR	NM_015849	NP_056933	P08218	CEL2B_HUMAN	elastase 2B preproprotein	270					proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1																		---	---	---	---
TMEM82	388595	broad.mit.edu	37	1	16069351	16069351	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16069351T>A	uc001axc.2	+	2	248	c.110T>A	c.(109-111)GTC>GAC	p.V37D		NM_001013641	NP_001013663	A0PJX8	TMM82_HUMAN	transmembrane protein 82	37	Leu-rich.|Helical; (Potential).					integral to membrane				breast(1)|central_nervous_system(1)	2		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16257562	16257562	+	Silent	SNP	A	G	G	rs139671958	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16257562A>G	uc001axk.1	+	11	5031	c.4827A>G	c.(4825-4827)AAA>AAG	p.K1609K	SPEN_uc010obp.1_Silent_p.K1568K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1609	Potential.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
ZBTB17	7709	broad.mit.edu	37	1	16271569	16271569	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16271569C>T	uc001axl.3	-	7	1029	c.790G>A	c.(790-792)GAG>AAG	p.E264K	ZBTB17_uc010obq.1_Missense_Mutation_p.E181K|ZBTB17_uc010obr.1_Missense_Mutation_p.E264K|ZBTB17_uc010obs.1_Missense_Mutation_p.E188K|ZBTB17_uc010obt.1_Missense_Mutation_p.E201K|ZBTB17_uc010obu.1_Missense_Mutation_p.E188K|ZBTB17_uc009vom.1_Missense_Mutation_p.E207K	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	264					negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
FBXO42	54455	broad.mit.edu	37	1	16577504	16577504	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16577504C>T	uc001ayg.2	-	10	2031	c.1815G>A	c.(1813-1815)GGG>GGA	p.G605G	FBXO42_uc001aye.3_Silent_p.G323G|FBXO42_uc001ayf.2_Silent_p.G512G	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	605										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)														---	---	---	---
NBPF1	55672	broad.mit.edu	37	1	16895594	16895594	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16895594T>C	uc009vos.1	-	23	3476	c.2588A>G	c.(2587-2589)CAA>CGA	p.Q863R	NBPF1_uc009vot.1_Missense_Mutation_p.Q321R|NBPF1_uc001ayz.1_Missense_Mutation_p.Q321R|NBPF1_uc010oce.1_Missense_Mutation_p.Q592R	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	863	NBPF 4.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)														---	---	---	---
RCC2	55920	broad.mit.edu	37	1	17749323	17749323	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17749323T>C	uc001bal.2	-	4	580	c.533A>G	c.(532-534)GAG>GGG	p.E178G	RCC2_uc001bam.2_Missense_Mutation_p.E178G	NM_001136204	NP_001129676	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2	178	RCC1 2.				cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle					0		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)														---	---	---	---
ACTL8	81569	broad.mit.edu	37	1	18149614	18149614	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:18149614G>A	uc001bat.2	+	2	327	c.111G>A	c.(109-111)CCG>CCA	p.P37P		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	37						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)														---	---	---	---
PAX7	5081	broad.mit.edu	37	1	19018395	19018395	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19018395A>G	uc001bay.2	+	5	1332	c.734A>G	c.(733-735)TAC>TGC	p.Y245C	PAX7_uc001baz.2_Missense_Mutation_p.Y243C|PAX7_uc010oct.1_Missense_Mutation_p.Y245C	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	245	Homeobox.				anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)				T	FOXO1A	alveolar rhabdomyosarcoma								---	---	---	---
PAX7	5081	broad.mit.edu	37	1	19029776	19029776	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19029776G>T	uc001bay.2	+	7	1739	c.1141G>T	c.(1141-1143)GGC>TGC	p.G381C	PAX7_uc001baz.2_Missense_Mutation_p.G379C|PAX7_uc010oct.1_Missense_Mutation_p.G381C	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	381					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)				T	FOXO1A	alveolar rhabdomyosarcoma								---	---	---	---
ALDH4A1	8659	broad.mit.edu	37	1	19201970	19201970	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19201970A>G	uc001bbb.2	-	13	1642	c.1366T>C	c.(1366-1368)TAC>CAC	p.Y456H	ALDH4A1_uc010ocu.1_Missense_Mutation_p.Y396H|ALDH4A1_uc001bbc.2_Missense_Mutation_p.Y456H	NM_170726	NP_733844	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4A1 isoform a precursor	456					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)											OREG0013164	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19449347	19449347	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19449347A>T	uc001bbi.2	-	66	9800	c.9796T>A	c.(9796-9798)TAT>AAT	p.Y3266N	UBR4_uc001bbk.1_Missense_Mutation_p.Y913N	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3266					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
UBR4	23352	broad.mit.edu	37	1	19513925	19513925	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19513925A>G	uc001bbi.2	-							NM_020765	NP_065816			retinoblastoma-associated factor 600						interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)														---	---	---	---
KIF17	57576	broad.mit.edu	37	1	21009336	21009336	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21009336G>A	uc001bdr.3	-	11	2391	c.2273C>T	c.(2272-2274)GCC>GTC	p.A758V	KIF17_uc001bdp.3_Missense_Mutation_p.A36V|KIF17_uc001bdq.3_Missense_Mutation_p.A36V|KIF17_uc009vpx.2_Missense_Mutation_p.A128V|KIF17_uc001bds.3_Missense_Mutation_p.A758V	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	758	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)														---	---	---	---
HP1BP3	50809	broad.mit.edu	37	1	21083671	21083671	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21083671C>A	uc001bdw.1	-	9	1109	c.969G>T	c.(967-969)TCG>TCT	p.S323S	HP1BP3_uc001bdv.1_Silent_p.S285S|HP1BP3_uc010odh.1_Silent_p.S285S|HP1BP3_uc001bdy.1_Silent_p.S323S|HP1BP3_uc001bdz.2_RNA|HP1BP3_uc001bea.2_Silent_p.S322S|HP1BP3_uc010odf.1_5'UTR|HP1BP3_uc010odg.1_Silent_p.S171S	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	323	H15 2.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)														---	---	---	---
RAP1GAP	5909	broad.mit.edu	37	1	21938061	21938061	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21938061G>T	uc001bex.2	-	13	985	c.727C>A	c.(727-729)CTG>ATG	p.L243M	RAP1GAP_uc001bev.2_Missense_Mutation_p.L243M|RAP1GAP_uc001bew.2_Missense_Mutation_p.L307M|RAP1GAP_uc001bey.2_Missense_Mutation_p.L243M	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	243	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)														---	---	---	---
HSPG2	3339	broad.mit.edu	37	1	22169859	22169859	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22169859C>T	uc001bfj.2	-	66	8729	c.8689G>A	c.(8689-8691)GGA>AGA	p.G2897R	HSPG2_uc009vqd.2_Missense_Mutation_p.G2898R	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2897	Ig-like C2-type 14.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)													---	---	---	---
HSPG2	3339	broad.mit.edu	37	1	22179505	22179505	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22179505C>T	uc001bfj.2	-	51	6538	c.6498G>A	c.(6496-6498)GGG>GGA	p.G2166G	HSPG2_uc009vqd.2_Silent_p.G2167G	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2166	Ig-like C2-type 7.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)													---	---	---	---
EPHA8	2046	broad.mit.edu	37	1	22902826	22902826	+	Silent	SNP	C	T	T	rs145476843	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22902826C>T	uc001bfx.1	+	3	401	c.276C>T	c.(274-276)GAC>GAT	p.D92D	EPHA8_uc001bfw.2_Silent_p.D92D	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	92	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
EPHA8	2046	broad.mit.edu	37	1	22927263	22927263	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22927263C>T	uc001bfx.1	+	14	2623	c.2498C>T	c.(2497-2499)GCC>GTC	p.A833V		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	833	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
HTR1D	3352	broad.mit.edu	37	1	23520184	23520184	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23520184G>A	uc001bgn.2	-	1	1039	c.529C>T	c.(529-531)CGG>TGG	p.R177W		NM_000864	NP_000855	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D	177	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)													---	---	---	---
HNRNPR	10236	broad.mit.edu	37	1	23637458	23637458	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23637458T>C	uc001bgr.3	-	11	1550	c.1391A>G	c.(1390-1392)TAC>TGC	p.Y464C	HNRNPR_uc001bgo.2_Missense_Mutation_p.Y74C|HNRNPR_uc001bgp.3_Missense_Mutation_p.Y467C|HNRNPR_uc009vqk.2_Missense_Mutation_p.Y366C|HNRNPR_uc001bgs.3_Missense_Mutation_p.Y363C|HNRNPR_uc010odw.1_Missense_Mutation_p.Y426C|HNRNPR_uc010odx.1_Missense_Mutation_p.Y304C|HNRNPR_uc009vql.2_Missense_Mutation_p.Y325C	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	464	3 X 11 AA approximate repeats of D-D-Y-Y- G-Y-D-Y-H-D-Y.|RNA-binding RGG-box.|1; approximate.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
TCEB3	6924	broad.mit.edu	37	1	24077589	24077589	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24077589A>G	uc001bho.2	+	4	632	c.572A>G	c.(571-573)TAC>TGC	p.Y191C		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	191					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)												OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NIPAL3	57185	broad.mit.edu	37	1	24776017	24776017	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24776017T>C	uc001bjh.2	+	6	848	c.441T>C	c.(439-441)GGT>GGC	p.G147G	NIPAL3_uc010oek.1_Silent_p.G147G|NIPAL3_uc001bjg.2_Silent_p.G147G|NIPAL3_uc009vrc.2_Silent_p.G65G	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	147	Helical; (Potential).					integral to membrane					0																		---	---	---	---
TMEM50A	23585	broad.mit.edu	37	1	25678158	25678158	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25678158A>G	uc001bke.2	+	4	398	c.248A>G	c.(247-249)TAC>TGC	p.Y83C	TMEM50A_uc010oeq.1_Missense_Mutation_p.Y83C|TMEM50A_uc009vrr.2_RNA|TMEM50A_uc009vrs.2_RNA	NM_014313	NP_055128	O95807	TM50A_HUMAN	small membrane protein 1	83						endoplasmic reticulum|integral to membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;3.47e-27)|Colorectal(126;1.1e-08)|COAD - Colon adenocarcinoma(152;7.48e-07)|STAD - Stomach adenocarcinoma(196;0.00035)|BRCA - Breast invasive adenocarcinoma(304;0.00047)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|GBM - Glioblastoma multiforme(114;0.00106)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.204)														---	---	---	---
RHCE	6006	broad.mit.edu	37	1	25715467	25715467	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25715467C>T	uc001bkf.2	-	6	1025	c.939G>A	c.(937-939)CCG>CCA	p.P313P	RHCE_uc001bkg.2_Silent_p.P313P|RHCE_uc001bkh.2_Silent_p.P208P|RHCE_uc001bki.2_Intron|RHCE_uc001bkj.2_Silent_p.P297P	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	313						integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TMEM57	55219	broad.mit.edu	37	1	25775373	25775373	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25775373G>A	uc001bkk.2	+	3	499	c.297G>A	c.(295-297)TGG>TGA	p.W99*	TMEM57_uc009vru.2_Nonsense_Mutation_p.W99*|TMEM57_uc009vrv.2_Intron|TMEM57_uc009vrt.2_RNA	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	99						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TMEM57	55219	broad.mit.edu	37	1	25812245	25812245	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25812245A>G	uc001bkk.2	+	8	1657	c.1455A>G	c.(1453-1455)GAA>GAG	p.E485E	TMEM57_uc009vru.2_Silent_p.E258E|TMEM57_uc009vrv.2_Silent_p.E127E	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	485						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SEPN1	57190	broad.mit.edu	37	1	26135246	26135246	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26135246A>G	uc010oer.1	+	7	768	c.713A>G	c.(712-714)AAC>AGC	p.N238S	SEPN1_uc010oes.1_Missense_Mutation_p.N204S	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	238						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
FAM54B	56181	broad.mit.edu	37	1	26156176	26156176	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26156176A>G	uc001bkq.3	+	6	838	c.628A>G	c.(628-630)AGC>GGC	p.S210G	FAM54B_uc001bkr.3_Silent_p.P173P|FAM54B_uc010oet.1_Missense_Mutation_p.S243G|FAM54B_uc009vrz.2_Missense_Mutation_p.S195G|FAM54B_uc001bks.3_Missense_Mutation_p.S210G|FAM54B_uc001bkt.3_Missense_Mutation_p.S210G|FAM54B_uc001bku.3_Silent_p.P170P|FAM54B_uc001bkv.3_Missense_Mutation_p.S113G	NM_001099625	NP_001093095	Q9H019	FA54B_HUMAN	hypothetical protein LOC56181 isoform a	210										pancreas(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.96e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.00095)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
C1orf135	79000	broad.mit.edu	37	1	26162053	26162053	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26162053T>C	uc001bkw.1	-	3	505	c.505A>G	c.(505-507)ACC>GCC	p.T169A		NM_024037	NP_076942	Q9H7T9	CA135_HUMAN	aurora A-binding protein	169											0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00521)|all_lung(284;0.00764)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.117)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.28e-25)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000787)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
STMN1	3925	broad.mit.edu	37	1	26228173	26228173	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26228173A>G	uc001bkz.2	-	4	551	c.187T>C	c.(187-189)TCC>CCC	p.S63P	STMN1_uc010oev.1_Missense_Mutation_p.S63P|STMN1_uc001bla.2_Missense_Mutation_p.S63P|STMN1_uc001blb.2_Missense_Mutation_p.S63P|STMN1_uc001blc.2_Missense_Mutation_p.S63P	NM_203401	NP_981946	P16949	STMN1_HUMAN	stathmin 1 isoform a	63	Potential.				cell differentiation|intracellular signal transduction|microtubule depolymerization|mitotic spindle organization|nervous system development|response to virus	cytoplasm|microtubule	signal transducer activity|tubulin binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000163)|all_lung(284;0.000234)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.013)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CATSPER4	378807	broad.mit.edu	37	1	26517331	26517331	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26517331G>A	uc010oez.1	+	1	213	c.213G>A	c.(211-213)GCG>GCA	p.A71A	CATSPER4_uc010oey.1_5'UTR|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	71	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CCDC21	64793	broad.mit.edu	37	1	26582109	26582109	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26582109A>G	uc001bls.1	+	4	787	c.656A>G	c.(655-657)TAC>TGC	p.Y219C	CCDC21_uc001blr.2_Missense_Mutation_p.Y219C|CCDC21_uc010ofa.1_Missense_Mutation_p.Y168C	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	219						centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
AIM1L	55057	broad.mit.edu	37	1	26671786	26671786	+	5'Flank	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26671786C>T	uc001bmd.3	-						uc009vsi.1_Missense_Mutation_p.V455I	NM_001039775	NP_001034864			absent in melanoma 1-like								sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)														---	---	---	---
LIN28A	79727	broad.mit.edu	37	1	26751895	26751895	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26751895C>T	uc001bmj.2	+	3	444	c.330C>T	c.(328-330)ACC>ACT	p.T110T	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	110	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
C1orf172	126695	broad.mit.edu	37	1	27278358	27278358	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27278358A>G	uc001bni.1	-	2	603	c.514T>C	c.(514-516)TAT>CAT	p.Y172H		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	172										large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
WDTC1	23038	broad.mit.edu	37	1	27609836	27609836	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27609836G>A	uc009vst.2	+	5	722	c.187G>A	c.(187-189)GCC>ACC	p.A63T	WDTC1_uc001bno.2_Missense_Mutation_p.A63T|WDTC1_uc001bnp.1_RNA	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	63	WD 1.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)														---	---	---	---
WASF2	10163	broad.mit.edu	37	1	27744873	27744873	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27744873G>A	uc001bof.1	-	4	532	c.316C>T	c.(316-318)CAA>TAA	p.Q106*	WASF2_uc010ofl.1_Nonsense_Mutation_p.Q106*	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	106					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)														---	---	---	---
AHDC1	27245	broad.mit.edu	37	1	27875206	27875206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27875206C>T	uc009vsy.2	-	6	4390	c.3421G>A	c.(3421-3423)GTG>ATG	p.V1141M	AHDC1_uc009vsz.1_Missense_Mutation_p.V1141M	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1141							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)														---	---	---	---
C1orf38	9473	broad.mit.edu	37	1	28209163	28209163	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28209163C>T	uc001bpc.3	+	4	1356	c.1328C>T	c.(1327-1329)GCA>GTA	p.A443V	C1orf38_uc001boz.2_Intron|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Missense_Mutation_p.A247V|C1orf38_uc010ofo.1_Missense_Mutation_p.A314V	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	443	CABIT 2.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
RCC1	1104	broad.mit.edu	37	1	28862498	28862498	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28862498C>T	uc001bqg.1	+	7	862	c.777C>T	c.(775-777)GGC>GGT	p.G259G	SNHG3-RCC1_uc001bqa.1_Silent_p.G259G|SNHG3-RCC1_uc001bqb.1_Silent_p.G259G|SNHG3-RCC1_uc001bqc.1_Silent_p.G259G|RCC1_uc001bqe.1_Silent_p.G276G|RCC1_uc001bqf.1_Silent_p.G290G	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	259	RCC1 5.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SNHG12	85028	broad.mit.edu	37	1	28907424	28907424	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28907424T>C	uc001bqk.2	-						SNHG12_uc001bql.2_Intron|SNHG12_uc001bqm.2_RNA|SNHG12_uc001bqn.2_Intron|SNHG12_uc001bqo.2_RNA|SNHG12_uc001bqp.2_Intron|SNORD99_uc001bqq.1_5'Flank|SNORA61_uc001bqr.2_5'Flank|SNORA44_uc001bqs.2_5'Flank	NR_024127				Homo sapiens PNAS-123 mRNA, complete cds.												0																		---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29070470	29070470	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29070470G>A	uc001brc.2	+	4	2185	c.1688G>A	c.(1687-1689)CGC>CAC	p.R563H	YTHDF2_uc001brd.2_Missense_Mutation_p.R560H|YTHDF2_uc010ofx.1_Missense_Mutation_p.R513H|YTHDF2_uc001bre.2_Missense_Mutation_p.R513H	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	563					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PTPRU	10076	broad.mit.edu	37	1	29642617	29642617	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29642617G>A	uc001bru.2	+	25	3607	c.3497G>A	c.(3496-3498)CGC>CAC	p.R1166H	PTPRU_uc001brv.2_Missense_Mutation_p.R1162H|PTPRU_uc001brw.2_Missense_Mutation_p.R1156H|PTPRU_uc009vtq.2_Missense_Mutation_p.R1162H|PTPRU_uc009vtr.2_Missense_Mutation_p.R1153H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1166	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)														---	---	---	---
PUM1	9698	broad.mit.edu	37	1	31532150	31532150	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:31532150C>T	uc001bsi.1	-	2	377	c.264G>A	c.(262-264)CAG>CAA	p.Q88Q	PUM1_uc001bsh.1_Silent_p.Q88Q|PUM1_uc001bsj.1_Silent_p.Q88Q|PUM1_uc010oga.1_Silent_p.Q88Q|PUM1_uc001bsk.1_Silent_p.Q124Q|PUM1_uc010ogb.1_Silent_p.Q124Q	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	88					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
SERINC2	347735	broad.mit.edu	37	1	31899570	31899570	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:31899570A>G	uc010ogh.1	+	6	893	c.692A>G	c.(691-693)TAC>TGC	p.Y231C	SERINC2_uc010ogg.1_Missense_Mutation_p.Y228C|SERINC2_uc001bst.2_Missense_Mutation_p.Y227C|SERINC2_uc001bsu.2_Missense_Mutation_p.Y172C|SERINC2_uc001bsv.2_Missense_Mutation_p.Y172C	NM_178865	NP_849196	Q96SA4	SERC2_HUMAN	tumor differentially expressed 2-like	227						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0629)|Breast(348;0.0707)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0541)|READ - Rectum adenocarcinoma(331;0.151)														---	---	---	---
BAI2	576	broad.mit.edu	37	1	32221679	32221679	+	Silent	SNP	G	A	A	rs139265180		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32221679G>A	uc001btn.2	-	4	1113	c.759C>T	c.(757-759)CCC>CCT	p.P253P	BAI2_uc010ogp.1_Silent_p.P241P|BAI2_uc010ogq.1_Silent_p.P253P|BAI2_uc001bto.2_Silent_p.P253P|BAI2_uc001btq.1_Silent_p.P241P|BAI2_uc010ogr.1_Silent_p.P241P	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	253	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)														---	---	---	---
CCDC28B	79140	broad.mit.edu	37	1	32667684	32667684	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32667684C>T	uc001bul.1	+	2	280	c.148C>T	c.(148-150)CGG>TGG	p.R50W	CCDC28B_uc001buk.2_Missense_Mutation_p.R50W	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	50											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
IQCC	55721	broad.mit.edu	37	1	32673020	32673020	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32673020C>T	uc001bum.2	+	5	785	c.738C>T	c.(736-738)GAC>GAT	p.D246D	IQCC_uc009vua.2_Silent_p.D326D|IQCC_uc010ogz.1_Silent_p.D146D|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	246										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
EIF3I	8668	broad.mit.edu	37	1	32694367	32694367	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32694367C>T	uc001bur.3	+	9	1212	c.679C>T	c.(679-681)CGG>TGG	p.R227W	EIF3I_uc009vuc.2_Missense_Mutation_p.R227W|EIF3I_uc001bus.2_Missense_Mutation_p.R179W	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	227						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)																---	---	---	---
HDAC1	3065	broad.mit.edu	37	1	32796452	32796452	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32796452G>A	uc001bvb.1	+	9	985	c.922G>A	c.(922-924)GTT>ATT	p.V308I	HDAC1_uc010ohf.1_Missense_Mutation_p.V279I|HDAC1_uc001bvc.1_Missense_Mutation_p.V64I	NM_004964	NP_004955	Q13547	HDAC1_HUMAN	histone deacetylase 1	308	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)	3		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)													---	---	---	---
MARCKSL1	65108	broad.mit.edu	37	1	32801637	32801637	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32801637T>C	uc001bvd.2	-	1						NM_023009	NP_075385			MARCKS-like 1							plasma membrane	calmodulin binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
BSDC1	55108	broad.mit.edu	37	1	32842196	32842196	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32842196T>C	uc001bvh.3	-	9	870	c.823A>G	c.(823-825)ACT>GCT	p.T275A	BSDC1_uc010ohg.1_Missense_Mutation_p.T292A|BSDC1_uc010ohh.1_Missense_Mutation_p.T219A|BSDC1_uc010ohi.1_Missense_Mutation_p.T180A|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Missense_Mutation_p.T171A|BSDC1_uc001bvi.2_Missense_Mutation_p.T292A	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	275							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
RBBP4	5928	broad.mit.edu	37	1	33117607	33117607	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33117607A>G	uc001bvr.2	+	2	268	c.109A>G	c.(109-111)ACC>GCC	p.T37A	ZBTB8OS_uc001bvo.1_5'Flank|ZBTB8OS_uc001bvp.2_5'Flank|ZBTB8OS_uc001bvq.2_5'Flank|RBBP4_uc001bvs.2_Missense_Mutation_p.T36A|RBBP4_uc010ohj.1_5'UTR|RBBP4_uc010ohk.1_Missense_Mutation_p.T2A	NM_005610	NP_005601	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4 isoform a	37					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)																---	---	---	---
YARS	8565	broad.mit.edu	37	1	33282780	33282780	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33282780A>G	uc001bvy.1	-						S100PBP_uc001bvz.2_5'Flank|S100PBP_uc001bwa.1_5'Flank|S100PBP_uc001bwb.1_5'Flank|S100PBP_uc001bwc.2_5'Flank	NM_003680	NP_003671			tyrosyl-tRNA synthetase						apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)													---	---	---	---
TMEM54	113452	broad.mit.edu	37	1	33360402	33360402	+	3'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33360402T>C	uc001bwi.1	-	6					TMEM54_uc001bwj.1_3'UTR|TMEM54_uc001bwk.1_3'UTR	NM_033504	NP_277039			transmembrane protein 54							integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
RNF19B	127544	broad.mit.edu	37	1	33415365	33415365	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33415365T>C	uc010oho.1	-	2	646	c.646A>G	c.(646-648)ATT>GTT	p.I216V	RNF19B_uc001bwm.3_Missense_Mutation_p.I216V|RNF19B_uc010ohp.1_Missense_Mutation_p.I216V	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	216	IBR-type.					integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)																---	---	---	---
ZSCAN20	7579	broad.mit.edu	37	1	33956657	33956657	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33956657G>A	uc001bxj.3	+	6	966	c.799G>A	c.(799-801)GAG>AAG	p.E267K	ZSCAN20_uc001bxk.2_Missense_Mutation_p.E213K|ZSCAN20_uc009vui.2_Missense_Mutation_p.E267K	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	267					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)																---	---	---	---
ZSCAN20	7579	broad.mit.edu	37	1	33956724	33956724	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33956724A>T	uc001bxj.3	+	6	1033	c.866A>T	c.(865-867)GAT>GTT	p.D289V	ZSCAN20_uc001bxk.2_Missense_Mutation_p.D235V|ZSCAN20_uc009vui.2_Missense_Mutation_p.D289V	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	289					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)																---	---	---	---
ZSCAN20	7579	broad.mit.edu	37	1	33960491	33960491	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33960491T>C	uc001bxj.3	+	8	2714	c.2547T>C	c.(2545-2547)GCT>GCC	p.A849A	ZSCAN20_uc009vui.2_Silent_p.A848A	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	849					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34383804	34383804	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34383804T>C	uc001bxn.1	-	5	720	c.691A>G	c.(691-693)ACC>GCC	p.T231A	CSMD2_uc001bxm.1_Missense_Mutation_p.T271A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	231	CUB 2.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	34383824	34383824	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:34383824T>C	uc001bxn.1	-	5	700	c.671A>G	c.(670-672)AAC>AGC	p.N224S	CSMD2_uc001bxm.1_Missense_Mutation_p.N264S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	224	CUB 2.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
GJB4	127534	broad.mit.edu	37	1	35226975	35226975	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35226975G>T	uc001bxv.1	+	2	490	c.120G>T	c.(118-120)GCG>GCT	p.A40A	GJB4_uc001bxw.3_Silent_p.A40A	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	40	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)																---	---	---	---
GJB3	2707	broad.mit.edu	37	1	35250706	35250706	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35250706A>G	uc001bxx.2	+	2	958	c.343A>G	c.(343-345)AAG>GAG	p.K115E	GJB3_uc001bxy.2_Missense_Mutation_p.K115E|GJB3_uc001bxz.3_Missense_Mutation_p.K115E|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	115	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)																---	---	---	---
GJA4	2701	broad.mit.edu	37	1	35260075	35260075	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35260075A>G	uc001bya.2	+	2	349	c.261A>G	c.(259-261)ACA>ACG	p.T87T	GJA4_uc009vul.2_Silent_p.T163T|GJA4_uc009vum.1_Silent_p.T87T	NM_002060	NP_002051	P35212	CXA4_HUMAN	connexin 37	87	Helical; (Potential).				cell-cell junction assembly	integral to plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)																---	---	---	---
ZMYM4	9202	broad.mit.edu	37	1	35864507	35864507	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35864507T>C	uc001byt.2	+	22	3376	c.3296T>C	c.(3295-3297)GTA>GCA	p.V1099A	ZMYM4_uc009vuu.2_Missense_Mutation_p.V1067A|ZMYM4_uc001byu.2_Missense_Mutation_p.V775A|ZMYM4_uc009vuv.2_Missense_Mutation_p.V838A	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1099					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
CLSPN	63967	broad.mit.edu	37	1	36202565	36202565	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36202565T>C	uc001bzi.2	-	24	3939	c.3859A>G	c.(3859-3861)ACA>GCA	p.T1287A	CLSPN_uc009vux.2_Missense_Mutation_p.T1223A	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	1287					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
EIF2C1	26523	broad.mit.edu	37	1	36358271	36358271	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36358271A>G	uc001bzl.2	+	3	536	c.323A>G	c.(322-324)AAC>AGC	p.N108S	EIF2C1_uc001bzk.2_Missense_Mutation_p.N33S|EIF2C1_uc009vuy.2_5'Flank	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	108					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
EIF2C1	26523	broad.mit.edu	37	1	36367936	36367936	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36367936C>T	uc001bzl.2	+	11	1608	c.1395C>T	c.(1393-1395)CTC>CTT	p.L465L	EIF2C1_uc001bzk.2_Silent_p.L390L|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	465					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
ADPRHL2	54936	broad.mit.edu	37	1	36557305	36557305	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36557305G>A	uc001bzt.2	+	3	448	c.395G>A	c.(394-396)TGT>TAT	p.C132Y	ADPRHL2_uc001bzu.2_5'UTR	NM_017825	NP_060295	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	132						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			pancreas(1)	1		Myeloproliferative disorder(586;0.0393)																---	---	---	---
TRAPPC3	27095	broad.mit.edu	37	1	36602838	36602838	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36602838C>T	uc001bzx.2	-	5	597	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	TRAPPC3_uc001bzy.2_Missense_Mutation_p.R124Q	NM_014408	NP_055223	O43617	TPPC3_HUMAN	trafficking protein particle complex 3	170						endoplasmic reticulum	guanylate cyclase activity|heme binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0393)																---	---	---	---
MAP7D1	55700	broad.mit.edu	37	1	36645665	36645665	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36645665A>G	uc001bzz.2	+	16	2728	c.2512A>G	c.(2512-2514)ACA>GCA	p.T838A	MAP7D1_uc001caa.2_Missense_Mutation_p.T805A|MAP7D1_uc001cab.2_Missense_Mutation_p.T800A|MAP7D1_uc001cac.2_Missense_Mutation_p.T537A|MAP7D1_uc001cad.2_Missense_Mutation_p.T374A	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	838						cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)																---	---	---	---
CSF3R	1441	broad.mit.edu	37	1	36940985	36940985	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36940985G>A	uc001caw.1	-	4	532	c.354C>T	c.(352-354)CGC>CGT	p.R118R	CSF3R_uc001cau.1_5'Flank|CSF3R_uc001cav.1_Silent_p.R118R|CSF3R_uc001cax.1_Silent_p.R118R|CSF3R_uc001cay.1_Silent_p.R118R	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	118	Extracellular (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)													---	---	---	---
SNIP1	79753	broad.mit.edu	37	1	38005863	38005863	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38005863T>C	uc001cbi.2	-	3	894	c.821A>G	c.(820-822)TAC>TGC	p.Y274C	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	274					production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)																---	---	---	---
GNL2	29889	broad.mit.edu	37	1	38056365	38056365	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38056365A>G	uc001cbk.2	-	4	489	c.326T>C	c.(325-327)GTT>GCT	p.V109A	GNL2_uc010oif.1_5'UTR|GNL2_uc009vve.2_Missense_Mutation_p.V109A	NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	109					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)																---	---	---	---
POU3F1	5453	broad.mit.edu	37	1	38511620	38511620	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38511620G>A	uc001ccp.1	-	1	831	c.796C>T	c.(796-798)CGC>TGC	p.R266C		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	266	POU-specific.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)																---	---	---	---
RHBDL2	54933	broad.mit.edu	37	1	39353627	39353627	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39353627G>A	uc001ccu.1	-						RHBDL2_uc010oin.1_Intron|RHBDL2_uc010oio.1_Intron	NM_017821	NP_060291			rhomboid protease 2						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)															---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39765930	39765930	+	Missense_Mutation	SNP	G	A	A	rs140369443	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39765930G>A	uc010ois.1	+	23	2750	c.2545G>A	c.(2545-2547)GTT>ATT	p.V849I	MACF1_uc001cda.1_Missense_Mutation_p.V757I|MACF1_uc001cdc.1_5'UTR|MACF1_uc009vvq.1_5'UTR|MACF1_uc001cdb.1_5'UTR	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	849					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39920622	39920622	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39920622G>A	uc010oiu.1	+	54	16388	c.16257G>A	c.(16255-16257)ACG>ACA	p.T5419T	MACF1_uc010ois.1_Silent_p.T4917T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	6875					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39950380	39950380	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39950380A>G	uc010oiu.1	+	63	17669	c.17538A>G	c.(17536-17538)ACA>ACG	p.T5846T	MACF1_uc010ois.1_Silent_p.T5338T|MACF1_uc001cde.1_Silent_p.T252T|MACF1_uc001cdf.1_Silent_p.T221T|MACF1_uc001cdg.2_Silent_p.T166T|MACF1_uc001cdh.2_Silent_p.T129T	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7296	Ser-rich.|C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
PABPC4	8761	broad.mit.edu	37	1	40029377	40029377	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40029377G>A	uc010oiv.1	-	12	2427	c.1529C>T	c.(1528-1530)GCT>GTT	p.A510V	PABPC4_uc001cdl.2_Missense_Mutation_p.A526V|PABPC4_uc001cdm.2_Missense_Mutation_p.A497V	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	510	Poly-Ala.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
PABPC4	8761	broad.mit.edu	37	1	40038101	40038101	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40038101A>G	uc010oiv.1	-	2	1249	c.351T>C	c.(349-351)GAT>GAC	p.D117D	PABPC4_uc001cdl.2_Silent_p.D117D|PABPC4_uc001cdm.2_Silent_p.D117D	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	117	RRM 2.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
RLF	6018	broad.mit.edu	37	1	40661362	40661362	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40661362T>C	uc001cfc.3	+	4	564	c.533T>C	c.(532-534)GTT>GCT	p.V178A		NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	178					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)															---	---	---	---
ZNF684	127396	broad.mit.edu	37	1	41012267	41012267	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41012267A>C	uc001cft.1	+	5	523	c.272A>C	c.(271-273)AAG>ACG	p.K91T		NM_152373	NP_689586	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)															---	---	---	---
SLFNL1	200172	broad.mit.edu	37	1	41486096	41486096	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:41486096C>T	uc001cgm.1	-	2	457	c.237G>A	c.(235-237)GCG>GCA	p.A79A	SLFNL1_uc009vwf.1_Silent_p.A79A|SLFNL1_uc001cgn.1_Silent_p.A79A|SLFNL1_uc009vwg.1_Silent_p.A79A	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	79							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)																---	---	---	---
ERMAP	114625	broad.mit.edu	37	1	43300699	43300699	+	Intron	SNP	T	C	C	rs55744487		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43300699T>C	uc001cic.1	+						ERMAP_uc010ojw.1_Intron|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Intron|ERMAP_uc001cif.1_Intron	NM_001017922	NP_001017922			erythroblast membrane-associated protein							integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
C1orf210	149466	broad.mit.edu	37	1	43748598	43748598	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43748598C>T	uc001cit.3	-	3	434	c.200G>A	c.(199-201)CGC>CAC	p.R67H		NM_182517	NP_872323	Q8IVY1	CA210_HUMAN	hypothetical protein LOC149466	67	Cytoplasmic (Potential).					integral to membrane					0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
TIE1	7075	broad.mit.edu	37	1	43773195	43773195	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43773195T>C	uc001ciu.2	+	6	944	c.865T>C	c.(865-867)TAT>CAT	p.Y289H	TIE1_uc010okd.1_Missense_Mutation_p.Y289H|TIE1_uc010oke.1_Missense_Mutation_p.Y244H|TIE1_uc009vwq.2_Missense_Mutation_p.Y245H|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'UTR|TIE1_uc010okc.1_Missense_Mutation_p.Y289H	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	289	Extracellular (Potential).|EGF-like 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
TIE1	7075	broad.mit.edu	37	1	43785145	43785145	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43785145C>T	uc001ciu.2	+	19	3131	c.3052C>T	c.(3052-3054)CGC>TGC	p.R1018C	TIE1_uc010oke.1_Missense_Mutation_p.R973C|TIE1_uc009vwq.2_Missense_Mutation_p.R974C|TIE1_uc010okg.1_Missense_Mutation_p.R663C	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	1018	Cytoplasmic (Potential).|Protein kinase.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
KIAA0467	23334	broad.mit.edu	37	1	43891705	43891705	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43891705G>A	uc001cjk.1	+						KIAA0467_uc009vws.1_Intron	NM_015284	NP_056099			hypothetical protein LOC23334							peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
KIAA0467	23334	broad.mit.edu	37	1	43893400	43893400	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43893400C>T	uc001cjk.1	+	11	1563	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1266						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44432664	44432664	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44432664T>C	uc001ckx.2	+	18	3381	c.2586T>C	c.(2584-2586)GGT>GGC	p.G862G	IPO13_uc001cky.2_Silent_p.G80G	NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	862					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
ERI3	79033	broad.mit.edu	37	1	44804743	44804743	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44804743A>G	uc001clt.2	-	3	704	c.463T>C	c.(463-465)TGC>CGC	p.C155R	ERI3_uc010okv.1_Intron|ERI3_uc009vxg.2_Missense_Mutation_p.C155R|ERI3_uc010okw.1_Missense_Mutation_p.C77R|ERI3_uc001clu.2_Missense_Mutation_p.C77R	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	155	Exonuclease.					intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
ERI3	79033	broad.mit.edu	37	1	44804978	44804978	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44804978T>C	uc001clt.2	-	3	469	c.228A>G	c.(226-228)GGA>GGG	p.G76G	ERI3_uc010okv.1_Intron|ERI3_uc009vxg.2_Silent_p.G76G|ERI3_uc010okw.1_5'UTR|ERI3_uc001clu.2_5'UTR	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	76						intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
BEST4	266675	broad.mit.edu	37	1	45250930	45250930	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45250930G>A	uc001cmm.2	-	6	811	c.762C>T	c.(760-762)GGC>GGT	p.G254G		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	254	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
MAST2	23139	broad.mit.edu	37	1	46496683	46496683	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46496683C>T	uc001cov.2	+	23	2996	c.2713C>T	c.(2713-2715)CGG>TGG	p.R905W	MAST2_uc001cow.2_Missense_Mutation_p.R905W|MAST2_uc001coy.1_Missense_Mutation_p.R579W|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	905					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)																	---	---	---	---
RAD54L	8438	broad.mit.edu	37	1	46715667	46715667	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46715667C>T	uc009vye.2	+						RAD54L_uc001cpl.2_Intron	NM_001142548	NP_001136020			RAD54-like protein						meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)									Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
TAL1	6886	broad.mit.edu	37	1	47691500	47691500	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47691500C>T	uc001cqx.2	-	2	638	c.61G>A	c.(61-63)GCG>ACG	p.A21T	TAL1_uc009vyq.2_5'Flank|TAL1_uc001cqy.2_Missense_Mutation_p.A21T|TAL1_uc001cra.1_Intron|TAL1_uc001cqz.1_Intron	NM_003189	NP_003180	P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	21					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			lung(1)	1								T	TRD@|SIL	lymphoblastic leukemia/biphasic								---	---	---	---
BEND5	79656	broad.mit.edu	37	1	49201945	49201945	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:49201945T>C	uc001crx.3	-	5	1118	c.1074A>G	c.(1072-1074)CCA>CCG	p.P358P	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Silent_p.P189P	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	358	BEN.									skin(1)	1																		---	---	---	---
TTC39A	22996	broad.mit.edu	37	1	51767291	51767291	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51767291A>G	uc001csl.2	-	12	1219	c.1114T>C	c.(1114-1116)TCC>CCC	p.S372P	TTC39A_uc001csk.2_Missense_Mutation_p.S337P|TTC39A_uc010ond.1_Missense_Mutation_p.S309P|TTC39A_uc010one.1_Missense_Mutation_p.S336P|TTC39A_uc010onf.1_Missense_Mutation_p.S340P|TTC39A_uc001csn.2_Missense_Mutation_p.S371P|TTC39A_uc001cso.1_3'UTR|TTC39A_uc009vyy.1_Missense_Mutation_p.S309P	NM_001080494	NP_001073963	Q5SRH9	TT39A_HUMAN	tetratricopeptide repeat domain 39A isoform 2	372							binding			skin(1)	1																		---	---	---	---
EPS15	2060	broad.mit.edu	37	1	51866629	51866629	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51866629T>C	uc001csq.1	-						EPS15_uc009vyz.1_Intron|EPS15_uc001csp.3_Intron	NM_001981	NP_001972			epidermal growth factor receptor pathway						cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2								T	MLL	ALL								---	---	---	---
OSBPL9	114883	broad.mit.edu	37	1	52252277	52252277	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52252277A>G	uc001cst.2	+	22	2007	c.1988A>G	c.(1987-1989)TAT>TGT	p.Y663C	OSBPL9_uc001css.2_Missense_Mutation_p.Y668C|OSBPL9_uc001csx.2_RNA|OSBPL9_uc009vza.2_Missense_Mutation_p.Y664C|OSBPL9_uc001csu.2_Missense_Mutation_p.Y673C|OSBPL9_uc001csv.2_Missense_Mutation_p.Y498C|OSBPL9_uc001csw.2_Missense_Mutation_p.Y650C|OSBPL9_uc001csy.2_Missense_Mutation_p.Y485C|OSBPL9_uc001csz.2_Missense_Mutation_p.Y485C|OSBPL9_uc001cta.2_Missense_Mutation_p.Y553C|OSBPL9_uc001ctb.2_Missense_Mutation_p.Y448C	NM_024586	NP_078862	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9 isoform e	663					lipid transport		lipid binding			central_nervous_system(1)	1																		---	---	---	---
ZCCHC11	23318	broad.mit.edu	37	1	52961105	52961105	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52961105A>G	uc001ctx.2	-	6	1494	c.1260T>C	c.(1258-1260)CCT>CCC	p.P420P	ZCCHC11_uc001cty.2_Silent_p.P420P|ZCCHC11_uc001ctz.2_Silent_p.P420P|ZCCHC11_uc009vze.1_Silent_p.P420P|ZCCHC11_uc009vzf.1_Silent_p.P179P|ZCCHC11_uc001cub.2_Silent_p.P420P|ZCCHC11_uc001cuc.2_RNA	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	420					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
C1orf163	65260	broad.mit.edu	37	1	53153604	53153604	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53153604G>A	uc001cui.1	-	3	524	c.484C>T	c.(484-486)CCA>TCA	p.P162S		NM_023077	NP_075565	Q96BR5	SELR1_HUMAN	hypothetical protein LOC65260	162	Sel1-like 4.						binding				0																		---	---	---	---
SCP2	6342	broad.mit.edu	37	1	53513586	53513586	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53513586A>G	uc001cur.1	+	15	1646	c.1525A>G	c.(1525-1527)ACT>GCT	p.T509A	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_Missense_Mutation_p.T428A|SCP2_uc010onp.1_Missense_Mutation_p.T485A|SCP2_uc009vzi.1_Missense_Mutation_p.T465A|SCP2_uc010onq.1_Missense_Mutation_p.T105A|SCP2_uc001cut.1_Missense_Mutation_p.T102A|SCP2_uc001cuu.1_3'UTR	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	509	SCP2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1																		---	---	---	---
SLC1A7	6512	broad.mit.edu	37	1	53554604	53554604	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53554604G>A	uc001cuy.2	-	10	1577	c.1409C>T	c.(1408-1410)GCG>GTG	p.A470V	SLC1A7_uc001cux.2_Missense_Mutation_p.A123V	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	470	Helical; (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)													---	---	---	---
CPT2	1376	broad.mit.edu	37	1	53675834	53675834	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53675834T>C	uc001cvb.3	+	4	1003	c.488T>C	c.(487-489)CTG>CCG	p.L163P		NM_000098	NP_000089	P23786	CPT2_HUMAN	carnitine O-palmitoyltransferase precursor	163	Mitochondrial matrix (By similarity).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity				0					L-Carnitine(DB00583)|Perhexiline(DB01074)													---	---	---	---
GLIS1	148979	broad.mit.edu	37	1	53974836	53974836	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53974836C>T	uc001cvr.1	-	9	2229	c.1662G>A	c.(1660-1662)CGG>CGA	p.R554R		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	554					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
DIO1	1733	broad.mit.edu	37	1	54370370	54370370	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:54370370T>C	uc010onx.1	+	2	392	c.369T>C	c.(367-369)AGT>AGC	p.S123S	DIO1_uc010onw.1_Silent_p.S59S|DIO1_uc009vzl.2_Intron|DIO1_uc001cwb.2_Intron|DIO1_uc010ony.1_Silent_p.S123S|DIO1_uc001cwd.2_RNA|DIO1_uc001cwe.2_Intron|DIO1_uc001cwf.2_RNA|DIO1_uc001cwg.2_RNA	NM_000792	NP_000783	P49895	IOD1_HUMAN	deiodinase, iodothyronine, type I isoform a	123					hormone biosynthetic process|thyroid hormone generation	endoplasmic reticulum membrane|integral to membrane|plasma membrane	selenium binding|thyroxine 5'-deiodinase activity				0																		---	---	---	---
ACOT11	26027	broad.mit.edu	37	1	55065067	55065067	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55065067T>C	uc001cxm.1	+	8	945	c.863T>C	c.(862-864)GTG>GCG	p.V288A	ACOT11_uc001cxj.1_Missense_Mutation_p.V166A|ACOT11_uc001cxl.1_Missense_Mutation_p.V288A	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	288	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1																		---	---	---	---
ACOT11	26027	broad.mit.edu	37	1	55069590	55069590	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55069590C>T	uc001cxm.1	+	11	1214	c.1132C>T	c.(1132-1134)CCC>TCC	p.P378S	ACOT11_uc001cxj.1_Missense_Mutation_p.P256S|ACOT11_uc001cxl.1_Missense_Mutation_p.P378S	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	378	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1																		---	---	---	---
C1orf175	374977	broad.mit.edu	37	1	55175638	55175638	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55175638T>C	uc010ooe.1	+	24	4074	c.3750T>C	c.(3748-3750)CAT>CAC	p.H1250H	C1orf175_uc001cxq.2_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.H768H|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.H451H	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1250						integral to membrane	binding				0																		---	---	---	---
USP24	23358	broad.mit.edu	37	1	55624619	55624619	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55624619G>A	uc001cyg.3	-	9	823	c.823C>T	c.(823-825)CGA>TGA	p.R275*		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	387					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13																		---	---	---	---
C8B	732	broad.mit.edu	37	1	57415420	57415420	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57415420T>G	uc001cyp.2	-	6	739	c.672A>C	c.(670-672)CAA>CAC	p.Q224H	C8B_uc010oon.1_Missense_Mutation_p.Q162H|C8B_uc010ooo.1_Missense_Mutation_p.Q172H	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	224	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4																		---	---	---	---
C8B	732	broad.mit.edu	37	1	57425755	57425755	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57425755T>C	uc001cyp.2	-	2	254	c.187A>G	c.(187-189)ATT>GTT	p.I63V	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_Missense_Mutation_p.I11V	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	63					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4																		---	---	---	---
L1TD1	54596	broad.mit.edu	37	1	62676144	62676144	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62676144T>C	uc001dae.3	+	4	2000	c.1698T>C	c.(1696-1698)CAT>CAC	p.H566H		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	566										ovary(1)|skin(1)	2																		---	---	---	---
DOCK7	85440	broad.mit.edu	37	1	62970361	62970361	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62970361T>C	uc001daq.2	-	37	4711	c.4677A>G	c.(4675-4677)ATA>ATG	p.I1559M	DOCK7_uc001dan.2_Missense_Mutation_p.I1420M|DOCK7_uc001dao.2_Missense_Mutation_p.I1420M|DOCK7_uc001dap.2_Missense_Mutation_p.I1537M|DOCK7_uc001dam.2_Missense_Mutation_p.I739M|DOCK7_uc010oov.1_Missense_Mutation_p.I298M	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1568					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2																		---	---	---	---
CACHD1	57685	broad.mit.edu	37	1	65147750	65147750	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65147750C>T	uc001dbo.1	+	26	3499	c.3394C>T	c.(3394-3396)CGC>TGC	p.R1132C	CACHD1_uc001dbp.1_Missense_Mutation_p.R887C|CACHD1_uc001dbq.1_Missense_Mutation_p.R887C|CACHD1_uc010opa.1_Missense_Mutation_p.R376C	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1183	Cytoplasmic (Potential).				calcium ion transport	integral to membrane				ovary(2)	2																		---	---	---	---
RAVER2	55225	broad.mit.edu	37	1	65243402	65243402	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65243402A>G	uc001dbs.1	+	3	491	c.413A>G	c.(412-414)CAG>CGG	p.Q138R	RAVER2_uc001dbt.1_Missense_Mutation_p.Q17R|RAVER2_uc010opb.1_Missense_Mutation_p.Q17R	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	138	RRM 1.					cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1																		---	---	---	---
MIR101-1	406893	broad.mit.edu	37	1	65524156	65524156	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65524156A>G	hsa-mir-101-1|MI0000103	-			c.36A>G			uc001dbx.2_RNA																	0																		---	---	---	---
DNAJC6	9829	broad.mit.edu	37	1	65830470	65830470	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65830470T>C	uc001dcd.1	+	2	337	c.173_splice	c.e2+2	p.S58_splice	DNAJC6_uc001dcc.1_Splice_Site_p.S89_splice|DNAJC6_uc010opc.1_Splice_Site_p.S45_splice|DNAJC6_uc001dce.1_Splice_Site_p.S115_splice	NM_014787	NP_055602			DnaJ (Hsp40) homolog, subfamily C, member 6						cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3																		---	---	---	---
LEPR	3953	broad.mit.edu	37	1	66067119	66067119	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:66067119A>G	uc001dci.2	+	9	1241	c.1039A>G	c.(1039-1041)AAT>GAT	p.N347D	LEPR_uc001dcg.2_Missense_Mutation_p.N347D|LEPR_uc001dch.2_Missense_Mutation_p.N347D|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.N347D|LEPR_uc001dck.2_Missense_Mutation_p.N347D	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	347	Extracellular (Potential).|Ig-like.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)														---	---	---	---
SGIP1	84251	broad.mit.edu	37	1	67105497	67105497	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67105497A>T	uc001dcr.2	+	5	426	c.209A>T	c.(208-210)GAA>GTA	p.E70V		NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	70					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3																		---	---	---	---
SGIP1	84251	broad.mit.edu	37	1	67185012	67185012	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67185012G>A	uc001dcr.2	+	19	1883	c.1666G>A	c.(1666-1668)GCT>ACT	p.A556T	SGIP1_uc010opd.1_Missense_Mutation_p.A156T|SGIP1_uc001dcs.2_Missense_Mutation_p.A156T|SGIP1_uc001dct.2_Missense_Mutation_p.A158T|SGIP1_uc009wat.2_Missense_Mutation_p.A350T|SGIP1_uc001dcu.2_Missense_Mutation_p.A61T	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	556					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3																		---	---	---	---
WDR78	79819	broad.mit.edu	37	1	67337080	67337080	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67337080A>T	uc001dcx.2	-	6	969	c.913T>A	c.(913-915)TGT>AGT	p.C305S	WDR78_uc001dcy.2_Missense_Mutation_p.C305S|WDR78_uc001dcz.2_Missense_Mutation_p.C305S|WDR78_uc009waw.2_Missense_Mutation_p.C51S|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	305										ovary(2)	2																		---	---	---	---
GNG12	55970	broad.mit.edu	37	1	68171216	68171216	+	Missense_Mutation	SNP	T	C	C	rs139638442	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:68171216T>C	uc001dea.1	-	4	329	c.137A>G	c.(136-138)CAT>CGT	p.H46R		NM_018841	NP_061329	Q9UBI6	GBG12_HUMAN	G-protein gamma-12 subunit precursor	46					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0																		---	---	---	---
GNG12	55970	broad.mit.edu	37	1	68171242	68171242	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:68171242C>T	uc001dea.1	-	4	303	c.111G>A	c.(109-111)GCG>GCA	p.A37A		NM_018841	NP_061329	Q9UBI6	GBG12_HUMAN	G-protein gamma-12 subunit precursor	37					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0																		---	---	---	---
WLS	79971	broad.mit.edu	37	1	68564378	68564378	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:68564378A>T	uc001dee.2	-	12	1840	c.1569T>A	c.(1567-1569)TAT>TAA	p.Y523*	uc001deb.1_RNA|uc001dec.1_RNA	NM_001002292	NP_001002292	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 2	Error:Variant_position_missing_in_Q5T9L3_after_alignment					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0																		---	---	---	---
ZRANB2	9406	broad.mit.edu	37	1	71537916	71537916	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71537916T>C	uc001dft.2	-	6	468	c.401A>G	c.(400-402)TAC>TGC	p.Y134C	ZRANB2_uc001dfs.2_Missense_Mutation_p.Y134C	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	134					mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74957869	74957869	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74957869G>A	uc001dgf.1	+	23	2321	c.2270G>A	c.(2269-2271)CGG>CAG	p.R757Q	TNNI3K_uc001dge.1_Missense_Mutation_p.R858Q	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	757						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
C1orf173	127254	broad.mit.edu	37	1	75108709	75108709	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75108709A>G	uc001dgg.2	-	4	534	c.315_splice	c.e4+1	p.K105_splice		NM_001002912	NP_001002912			hypothetical protein LOC127254											ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5																		---	---	---	---
CRYZ	1429	broad.mit.edu	37	1	75180257	75180257	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75180257A>G	uc001dgk.2	-						CRYZ_uc001dgj.2_Intron|CRYZ_uc001dgl.2_Intron|CRYZ_uc001dgm.2_Intron	NM_001130042	NP_001123514			crystallin, zeta isoform a						protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)													---	---	---	---
CRYZ	1429	broad.mit.edu	37	1	75188918	75188918	+	Missense_Mutation	SNP	C	T	T	rs138254201	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75188918C>T	uc001dgk.2	-	4	653	c.148G>A	c.(148-150)GTG>ATG	p.V50M	CRYZ_uc001dgj.2_Missense_Mutation_p.V50M|CRYZ_uc001dgl.2_Missense_Mutation_p.V50M|CRYZ_uc001dgm.2_Translation_Start_Site	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	50					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)													---	---	---	---
LHX8	431707	broad.mit.edu	37	1	75606712	75606712	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75606712G>A	uc001dgo.2	+	5	974	c.310G>A	c.(310-312)GTT>ATT	p.V104I	LHX8_uc001dgq.2_Missense_Mutation_p.V43I	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	104	LIM zinc-binding 1.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
RABGGTB	5876	broad.mit.edu	37	1	76256992	76256992	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76256992T>C	uc001dgy.1	+	5	509	c.438T>C	c.(436-438)TCT>TCC	p.S146S	RABGGTB_uc009wbt.1_RNA|RABGGTB_uc001dha.1_Silent_p.S100S|RABGGTB_uc001dhc.1_5'Flank	NM_004582	NP_004573	P53611	PGTB2_HUMAN	RAB geranylgeranyltransferase, beta subunit	146	PFTB 3.				protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			ovary(1)	1																		---	---	---	---
PIGK	10026	broad.mit.edu	37	1	77620132	77620132	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:77620132A>G	uc001dhk.2	-	9	1031	c.986_splice	c.e9+1	p.S329_splice	PIGK_uc010orj.1_Splice_Site_p.S253_splice|PIGK_uc009wbx.2_Splice_Site_p.S235_splice|PIGK_uc001dhl.1_Missense_Mutation_p.Y330H	NM_005482	NP_005473			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
PIGK	10026	broad.mit.edu	37	1	77629529	77629529	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:77629529A>G	uc001dhk.2	-	6	629	c.584_splice	c.e6+1	p.R195_splice	PIGK_uc010orj.1_Splice_Site_p.R119_splice|PIGK_uc009wbx.2_Splice_Site_p.R101_splice|PIGK_uc001dhl.1_Splice_Site_p.R195_splice	NM_005482	NP_005473			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
PIGK	10026	broad.mit.edu	37	1	77676186	77676186	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:77676186A>G	uc001dhk.2	-						PIGK_uc010orj.1_Intron|PIGK_uc009wbx.2_Intron|PIGK_uc001dhl.1_Intron	NM_005482	NP_005473			phosphatidylinositol glycan anchor biosynthesis,						attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
FAM73A	374986	broad.mit.edu	37	1	78326981	78326981	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78326981A>G	uc001dhx.2	+	12	1380	c.1348A>G	c.(1348-1350)ACT>GCT	p.T450A	FAM73A_uc010ork.1_Missense_Mutation_p.T450A|FAM73A_uc010orl.1_Missense_Mutation_p.T412A|FAM73A_uc001dhy.1_3'UTR	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	450						integral to membrane				ovary(1)	1				Colorectal(170;0.226)														---	---	---	---
FAM73A	374986	broad.mit.edu	37	1	78329681	78329681	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78329681A>G	uc001dhx.2	+	13	1509	c.1477A>G	c.(1477-1479)AAT>GAT	p.N493D	FAM73A_uc010ork.1_Missense_Mutation_p.N493D|FAM73A_uc010orl.1_Missense_Mutation_p.N455D	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	493						integral to membrane				ovary(1)	1				Colorectal(170;0.226)														---	---	---	---
LPHN2	23266	broad.mit.edu	37	1	82372891	82372891	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:82372891A>T	uc001dit.3	+	4	444	c.263A>T	c.(262-264)GAT>GTT	p.D88V	LPHN2_uc001dis.2_Missense_Mutation_p.D88V|LPHN2_uc001diu.2_Missense_Mutation_p.D88V|LPHN2_uc001div.2_Missense_Mutation_p.D88V|LPHN2_uc009wcd.2_Missense_Mutation_p.D88V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	88	Extracellular (Potential).|SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)														---	---	---	---
PRKACB	5567	broad.mit.edu	37	1	84610152	84610152	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:84610152T>C	uc001djj.2	+						PRKACB_uc001djl.2_Silent_p.G36G|PRKACB_uc001dji.2_Intron|PRKACB_uc001djk.2_Silent_p.G36G	NM_002731	NP_002722			cAMP-dependent protein kinase catalytic subunit						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			lung(2)|ovary(1)	3				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)														---	---	---	---
SSX2IP	117178	broad.mit.edu	37	1	85130189	85130189	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85130189T>C	uc001dkh.2	-	7	859	c.584A>G	c.(583-585)AAT>AGT	p.N195S	SSX2IP_uc001dkf.2_Missense_Mutation_p.N168S|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Missense_Mutation_p.N168S|SSX2IP_uc001dki.2_Missense_Mutation_p.N195S|SSX2IP_uc010osa.1_Missense_Mutation_p.N168S|SSX2IP_uc001dkj.2_Missense_Mutation_p.N195S|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Missense_Mutation_p.N191S	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	195	Potential.				cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
MCOLN2	255231	broad.mit.edu	37	1	85424273	85424273	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85424273T>C	uc001dkm.2	-	3	591	c.350A>G	c.(349-351)TAC>TGC	p.Y117C	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	117						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)														---	---	---	---
MCOLN2	255231	broad.mit.edu	37	1	85431242	85431242	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85431242A>G	uc001dkm.2	-	2	468	c.227T>C	c.(226-228)GTC>GCC	p.V76A	MCOLN2_uc001dkn.2_RNA	NM_153259	NP_694991	Q8IZK6	MCLN2_HUMAN	mucolipin 2	76						integral to membrane	ion channel activity			ovary(3)|upper_aerodigestive_tract(1)	4				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)														---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85573706	85573706	+	Intron	SNP	T	C	C	rs142139663		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85573706T>C	uc001dkt.2	+						WDR63_uc009wcl.2_Intron	NM_145172	NP_660155			WD repeat domain 63											upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85594486	85594486	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85594486A>G	uc001dkt.2	+						WDR63_uc009wcl.2_Intron	NM_145172	NP_660155			WD repeat domain 63											upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85598648	85598648	+	Silent	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85598648C>G	uc001dkt.2	+	23	2834	c.2643C>G	c.(2641-2643)GTC>GTG	p.V881V	WDR63_uc009wcl.2_Silent_p.V842V	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	881										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
COL24A1	255631	broad.mit.edu	37	1	86591117	86591117	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86591117A>G	uc001dlj.2	-	3	944	c.902T>C	c.(901-903)GTG>GCG	p.V301A	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.V301A	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	301					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)														---	---	---	---
COL24A1	255631	broad.mit.edu	37	1	86591185	86591185	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86591185T>C	uc001dlj.2	-	3	876	c.834A>G	c.(832-834)GTA>GTG	p.V278V	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.V278V	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	278					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)														---	---	---	---
CLCA2	9635	broad.mit.edu	37	1	86921029	86921029	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:86921029C>T	uc001dlr.3	+	14	2813	c.2651C>T	c.(2650-2652)GCG>GTG	p.A884V		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	884	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)														---	---	---	---
CCBL2	56267	broad.mit.edu	37	1	89408756	89408756	+	Missense_Mutation	SNP	C	T	T	rs145574653	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89408756C>T	uc001dmp.2	-	13	1611	c.1234G>A	c.(1234-1236)GTT>ATT	p.V412I	CCBL2_uc001dmq.2_Missense_Mutation_p.V378I|CCBL2_uc001dmr.2_Missense_Mutation_p.V248I	NM_001008661	NP_001008661	Q6YP21	KAT3_HUMAN	kynurenine aminotransferase III isoform 1	412					biosynthetic process|kynurenine metabolic process|tryptophan catabolic process		cysteine-S-conjugate beta-lyase activity|kynurenine-glyoxylate transaminase activity|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding			ovary(1)	1		Lung NSC(277;0.123)		all cancers(265;0.0117)|Epithelial(280;0.0341)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GBP3	2635	broad.mit.edu	37	1	89479832	89479832	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89479832A>G	uc001dmt.2	-	5	764	c.559T>C	c.(559-561)TTG>CTG	p.L187L	GBP3_uc010oss.1_Silent_p.L108L|GBP3_uc001dmu.2_Silent_p.L53L|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	187						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)														---	---	---	---
GBP6	163351	broad.mit.edu	37	1	89848299	89848299	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89848299T>G	uc001dnf.2	+	8	1503	c.1229T>G	c.(1228-1230)CTC>CGC	p.L410R	GBP6_uc010ost.1_Missense_Mutation_p.L280R	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	410							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)														---	---	---	---
LRRC8B	23507	broad.mit.edu	37	1	90058418	90058418	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90058418A>G	uc001dni.2	+	8	2735	c.2228A>G	c.(2227-2229)CAT>CGT	p.H743R	LRRC8B_uc001dnh.2_Missense_Mutation_p.H743R|LRRC8B_uc001dnj.2_Missense_Mutation_p.H743R	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	743	LRR 12.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)														---	---	---	---
ZNF326	284695	broad.mit.edu	37	1	90493124	90493124	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:90493124T>C	uc001dnq.2	+	12	1752	c.1613T>C	c.(1612-1614)GTA>GCA	p.V538A	ZNF326_uc009wda.1_Missense_Mutation_p.V449A|ZNF326_uc001dnr.2_Missense_Mutation_p.V332A	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1	538	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)														---	---	---	---
ZNF644	84146	broad.mit.edu	37	1	91405701	91405701	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91405701T>C	uc001dnw.2	-	3	1352	c.1210A>G	c.(1210-1212)ACC>GCC	p.T404A	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.T404A	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
ZNF644	84146	broad.mit.edu	37	1	91406703	91406703	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91406703T>C	uc001dnw.2	-	3	350	c.208A>G	c.(208-210)AAT>GAT	p.N70D	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.N70D	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)														---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91781940	91781940	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91781940A>G	uc001doa.3	-						HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Intron|HFM1_uc001dob.3_Intron|HFM1_uc010osv.1_Intron	NM_001017975	NP_001017975			HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
CDC7	8317	broad.mit.edu	37	1	91977451	91977451	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91977451C>T	uc001doe.2	+	6	708	c.543C>T	c.(541-543)AGC>AGT	p.S181S	CDC7_uc001dof.2_Silent_p.S181S|CDC7_uc010osw.1_Silent_p.S153S|CDC7_uc009wdc.2_Silent_p.S181S|CDC7_uc009wdd.2_5'Flank	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	181	Protein kinase.				cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)														---	---	---	---
GLMN	11146	broad.mit.edu	37	1	92728468	92728468	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:92728468T>C	uc001dor.2	-	16	1540	c.1425A>G	c.(1423-1425)TTA>TTG	p.L475L	GLMN_uc009wdg.2_RNA|GLMN_uc001dos.2_Silent_p.L461L	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin	475					muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)										Multiple_Glomus_Tumors_(of_the_Skin)_Familial				---	---	---	---
CCDC18	343099	broad.mit.edu	37	1	93705385	93705385	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:93705385A>G	uc001dpq.2	+	21	3435	c.3267A>G	c.(3265-3267)GTA>GTG	p.V1089V	CCDC18_uc009wdl.1_Silent_p.V606V	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	970	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)														---	---	---	---
ABCA4	24	broad.mit.edu	37	1	94544999	94544999	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94544999A>G	uc001dqh.2	-	9	1222	c.1118T>C	c.(1117-1119)TTG>TCG	p.L373S	ABCA4_uc010otn.1_Missense_Mutation_p.L373S	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	373	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)														---	---	---	---
ABCD3	5825	broad.mit.edu	37	1	94980753	94980753	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94980753C>T	uc001dqn.3	+	22	1999	c.1897C>T	c.(1897-1899)CAT>TAT	p.H633Y	ABCD3_uc010oto.1_Missense_Mutation_p.H657Y|ABCD3_uc010otp.1_Missense_Mutation_p.H560Y|ABCD3_uc009wdr.2_Missense_Mutation_p.H523Y|ABCD3_uc001dqo.3_Missense_Mutation_p.H321Y	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	633	ABC transporter.			VGITLFTVSHRKSLWKHHE -> GWHHSLHLCLIGNLFGNI MR (in Ref. 3; CAA58470).	peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)														---	---	---	---
RWDD3	25950	broad.mit.edu	37	1	95709937	95709937	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:95709937A>G	uc009wdu.2	+	2	332	c.256A>G	c.(256-258)AAT>GAT	p.N86D	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Missense_Mutation_p.N71D|RWDD3_uc009wdt.2_Missense_Mutation_p.N86D|RWDD3_uc001drf.3_Missense_Mutation_p.N86D|RWDD3_uc001drh.3_Missense_Mutation_p.N71D|RWDD3_uc009wdv.2_Intron|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Missense_Mutation_p.N86D	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	86	RWD.					cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)														---	---	---	---
RWDD3	25950	broad.mit.edu	37	1	95710148	95710148	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:95710148T>C	uc009wdu.2	+	2	543	c.467T>C	c.(466-468)GTC>GCC	p.V156A	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Missense_Mutation_p.V141A|RWDD3_uc009wdt.2_Missense_Mutation_p.V156A|RWDD3_uc001drf.3_Missense_Mutation_p.V156A|RWDD3_uc001drh.3_Missense_Mutation_p.V141A|RWDD3_uc009wdv.2_RNA|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Missense_Mutation_p.V156A	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	156						cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)														---	---	---	---
LPPR4	9890	broad.mit.edu	37	1	99772369	99772369	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:99772369G>A	uc001dse.2	+	7	2201	c.2095G>A	c.(2095-2097)GGA>AGA	p.G699R	LPPR4_uc010oue.1_Missense_Mutation_p.G641R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	699							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)														---	---	---	---
FRRS1	391059	broad.mit.edu	37	1	100212942	100212942	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100212942G>A	uc001dsh.1	-	4	843	c.241C>T	c.(241-243)CGT>TGT	p.R81C		NM_001013660	NP_001013682	Q6ZNA5	FRRS1_HUMAN	stromal cell derived factor receptor 2 homolog	81	Reelin.				electron transport chain|transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.09e-06)|all_lung(203;0.000435)|Lung NSC(277;0.00201)		Epithelial(280;0.0718)|all cancers(265;0.126)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.206)														---	---	---	---
AGL	178	broad.mit.edu	37	1	100346744	100346744	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100346744A>G	uc001dsi.1	+						AGL_uc001dsj.1_Intron|AGL_uc001dsk.1_Intron|AGL_uc001dsl.1_Intron|AGL_uc001dsm.1_Intron|AGL_uc001dsn.1_Intron	NM_000642	NP_000633			amylo-1,6-glucosidase,						glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)														---	---	---	---
CDC14A	8556	broad.mit.edu	37	1	100949844	100949844	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100949844A>G	uc001dtg.3	+						CDC14A_uc009web.2_Intron|CDC14A_uc010oui.1_Intron|CDC14A_uc001dte.3_Intron|CDC14A_uc001dtf.2_Intron|CDC14A_uc009wed.1_Intron|CDC14A_uc009wee.2_Intron	NM_003672	NP_003663			CDC14 homolog A isoform 1						cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)														---	---	---	---
CDC14A	8556	broad.mit.edu	37	1	100964808	100964808	+	Missense_Mutation	SNP	G	A	A	rs148639495	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100964808G>A	uc001dtg.3	+	15	2233	c.1745G>A	c.(1744-1746)CGT>CAT	p.R582H	CDC14A_uc010oui.1_Missense_Mutation_p.R524H|CDC14A_uc001dtf.2_Missense_Mutation_p.R582H|CDC14A_uc009wed.1_Missense_Mutation_p.R289H|CDC14A_uc009wee.2_Missense_Mutation_p.R582H	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	582					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)														---	---	---	---
CDC14A	8556	broad.mit.edu	37	1	100964835	100964835	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100964835C>T	uc001dtg.3	+						CDC14A_uc010oui.1_Missense_Mutation_p.P533L|CDC14A_uc001dtf.2_Missense_Mutation_p.P591L|CDC14A_uc009wed.1_Missense_Mutation_p.P298L|CDC14A_uc009wee.2_Intron	NM_003672	NP_003663			CDC14 homolog A isoform 1						cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)														---	---	---	---
VCAM1	7412	broad.mit.edu	37	1	101194879	101194879	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101194879T>A	uc001dti.2	+	5	1265	c.1145T>A	c.(1144-1146)CTG>CAG	p.L382Q	VCAM1_uc001dtj.2_Intron|VCAM1_uc010ouj.1_Missense_Mutation_p.L320Q	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	382	Ig-like C2-type 4.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)													---	---	---	---
SLC30A7	148867	broad.mit.edu	37	1	101387377	101387377	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101387377A>G	uc001dtn.2	+	8	1009	c.822A>G	c.(820-822)ATA>ATG	p.I274M	SLC30A7_uc001dto.2_Missense_Mutation_p.I274M	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	274	Helical; (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)														---	---	---	---
SLC30A7	148867	broad.mit.edu	37	1	101431471	101431471	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101431471T>C	uc001dtn.2	+	10	1267	c.1080T>C	c.(1078-1080)ACT>ACC	p.T360T	SLC30A7_uc001dto.2_Silent_p.T360T	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	360	Cytoplasmic (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)														---	---	---	---
AMY2A	279	broad.mit.edu	37	1	104160673	104160673	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:104160673G>C	uc001dut.2	+	2	330	c.266G>C	c.(265-267)GGA>GCA	p.G89A	AMY2A_uc010ouq.1_Missense_Mutation_p.G89A	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	89					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)													---	---	---	---
NTNG1	22854	broad.mit.edu	37	1	107867505	107867505	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:107867505G>A	uc001dvh.3	+	3	1566	c.848G>A	c.(847-849)CGC>CAC	p.R283H	NTNG1_uc001dvf.3_Missense_Mutation_p.R283H|NTNG1_uc010out.1_Missense_Mutation_p.R283H|NTNG1_uc001dvc.3_Missense_Mutation_p.R283H|NTNG1_uc001dvd.1_Missense_Mutation_p.R283H	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	283	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)														---	---	---	---
VAV3	10451	broad.mit.edu	37	1	108507366	108507366	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108507366C>T	uc001dvk.1	-	1	180	c.126G>A	c.(124-126)CTG>CTA	p.L42L	VAV3_uc010ouw.1_Silent_p.L42L|VAV3_uc001dvl.1_5'Flank|VAV3_uc010oux.1_Silent_p.L42L	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	42	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)														---	---	---	---
FAM102B	284611	broad.mit.edu	37	1	109171289	109171289	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109171289C>T	uc010ouy.1	+							NM_001010883	NP_001010883			hypothetical protein LOC284611											large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)														---	---	---	---
TAF13	6884	broad.mit.edu	37	1	109607261	109607261	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109607261C>T	uc001dwm.1	-	4	314	c.259G>A	c.(259-261)GTC>ATC	p.V87I		NM_005645	NP_005636	Q15543	TAF13_HUMAN	TBP-associated factor 13	87					transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein C-terminus binding|sequence-specific DNA binding transcription factor activity				0		all_epithelial(167;0.000102)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0138)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.166)|all cancers(265;0.191)|LUSC - Lung squamous cell carcinoma(189;0.228)														---	---	---	---
KIAA1324	57535	broad.mit.edu	37	1	109742806	109742806	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109742806T>C	uc001dwq.2	+	21	2890	c.2754T>C	c.(2752-2754)TGT>TGC	p.C918C	KIAA1324_uc009wex.1_Silent_p.C868C|KIAA1324_uc009wey.2_Silent_p.C831C|KIAA1324_uc010ovg.1_Silent_p.C816C|KIAA1324_uc001dwr.2_Silent_p.C568C|KIAA1324_uc001dws.1_RNA|KIAA1324_uc009wez.1_RNA	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	918	Helical; (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)														---	---	---	---
CELSR2	1952	broad.mit.edu	37	1	109793883	109793883	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109793883T>A	uc001dxa.3	+	1	1243	c.1182T>A	c.(1180-1182)GAT>GAA	p.D394E		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	394	Cadherin 2.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)														---	---	---	---
GNAT2	2780	broad.mit.edu	37	1	110151277	110151277	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110151277T>C	uc001dya.2	-	4	650	c.437A>G	c.(436-438)TAC>TGC	p.Y146C		NM_005272	NP_005263	P19087	GNAT2_HUMAN	guanine nucleotide binding protein, alpha	146					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)														---	---	---	---
GSTM4	2948	broad.mit.edu	37	1	110199418	110199418	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110199418A>G	uc001dyf.2	+						GSTM4_uc009wfi.2_Missense_Mutation_p.T41A|GSTM4_uc001dyg.2_Intron|GSTM4_uc009wfj.2_Intron|GSTM4_uc001dyh.2_Intron|GSTM2_uc001dyi.2_Intron	NM_000850	NP_000841			glutathione S-transferase mu 4 isoform 1						xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0123)|Colorectal(144;0.0129)|Epithelial(280;0.0147)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.0471)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)													---	---	---	---
EPS8L3	79574	broad.mit.edu	37	1	110301149	110301149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110301149G>A	uc001dyr.1	-	7	743	c.598C>T	c.(598-600)CAC>TAC	p.H200Y	EPS8L3_uc001dys.1_Missense_Mutation_p.H200Y|EPS8L3_uc001dyq.1_Missense_Mutation_p.H201Y|EPS8L3_uc009wfm.1_Missense_Mutation_p.H167Y|EPS8L3_uc009wfn.1_Missense_Mutation_p.H167Y|EPS8L3_uc009wfo.1_Missense_Mutation_p.H147Y	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	200	Pro-rich.					cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)														---	---	---	---
SLC6A17	388662	broad.mit.edu	37	1	110734660	110734660	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110734660C>A	uc009wfq.2	+	7	1392	c.931C>A	c.(931-933)CTG>ATG	p.L311M	SLC6A17_uc001dze.1_5'Flank	NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	311	Helical; Name=6; (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)														---	---	---	---
C1orf103	55791	broad.mit.edu	37	1	111490689	111490689	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111490689C>T	uc001eaa.2	-	4	2458	c.2202G>A	c.(2200-2202)CCG>CCA	p.P734P	C1orf103_uc001dzz.2_Silent_p.P198P|C1orf103_uc001eab.2_Silent_p.P198P|C1orf103_uc001eac.1_Silent_p.P197P	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)														---	---	---	---
C1orf103	55791	broad.mit.edu	37	1	111506236	111506236	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111506236T>C	uc001eaa.2	-						C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842			receptor-interacting factor 1 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)												OREG0013667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CHIA	27159	broad.mit.edu	37	1	111857963	111857963	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111857963A>C	uc001eas.2	+	6	489	c.386A>C	c.(385-387)CAG>CCG	p.Q129P	CHIA_uc001ear.2_Missense_Mutation_p.Q21P|CHIA_uc001eaq.2_Missense_Mutation_p.Q21P|CHIA_uc009wgc.2_Missense_Mutation_p.Q21P|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_5'UTR|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	129					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)														---	---	---	---
CHIA	27159	broad.mit.edu	37	1	111861306	111861306	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111861306T>C	uc001eas.2	+						CHIA_uc001ear.2_Intron|CHIA_uc001eaq.2_Intron|CHIA_uc009wgc.2_Intron|CHIA_uc001eat.2_Intron|CHIA_uc001eav.2_Intron|CHIA_uc001eau.2_Intron|CHIA_uc009wgd.2_Intron	NM_201653	NP_970615			acidic chitinase isoform c						apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)														---	---	---	---
OVGP1	5016	broad.mit.edu	37	1	111959046	111959046	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111959046G>C	uc001eba.2	-	10	1111	c.1055C>G	c.(1054-1056)GCC>GGC	p.A352G	OVGP1_uc001eaz.2_Missense_Mutation_p.A314G|OVGP1_uc010owb.1_5'UTR	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	352					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)														---	---	---	---
ADORA3	140	broad.mit.edu	37	1	112031596	112031596	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:112031596C>T	uc001ebf.2	-	3	1275	c.508G>A	c.(508-510)GCT>ACT	p.A170T	ADORA3_uc001ebg.3_Missense_Mutation_p.A89T	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)													---	---	---	---
KCND3	3752	broad.mit.edu	37	1	112525069	112525069	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:112525069C>T	uc001ebu.1	-	2	760	c.280G>A	c.(280-282)GTG>ATG	p.V94M	KCND3_uc001ebv.1_Missense_Mutation_p.V94M	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	94	Cytoplasmic (Potential).		V -> M (in a colorectal cancer sample; somatic mutation).			sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding	p.V94M(1)		ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)														---	---	---	---
PPM1J	333926	broad.mit.edu	37	1	113252813	113252813	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113252813G>A	uc001ect.1	-	10	1517	c.1490C>T	c.(1489-1491)CCC>CTC	p.P497L	RHOC_uc001ecq.1_5'Flank|RHOC_uc001ecr.1_5'Flank|RHOC_uc009wgk.1_5'Flank|PPM1J_uc009wgl.1_Intron|PPM1J_uc001ecs.1_Missense_Mutation_p.P291L	NM_005167	NP_005158	Q5JR12	PPM1J_HUMAN	protein phosphatase 1J (PP2C domain containing)	497	PP2C-like.									breast(2)|central_nervous_system(1)	3	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113638869	113638869	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113638869C>T	uc001edf.1	+	8	1171	c.973C>T	c.(973-975)CGC>TGC	p.R325C	LRIG2_uc009wgn.1_Missense_Mutation_p.R222C	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	325	LRR 11.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
DCLRE1B	64858	broad.mit.edu	37	1	114450657	114450657	+	Missense_Mutation	SNP	C	G	G	rs34762757		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114450657C>G	uc001eeg.2	+	3	553	c.382C>G	c.(382-384)CTA>GTA	p.L128V	AP4B1_uc001eed.2_5'Flank|AP4B1_uc010owp.1_5'Flank|DCLRE1B_uc001eeh.2_Missense_Mutation_p.L2V|DCLRE1B_uc001eei.2_Missense_Mutation_p.L2V	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	128					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)									Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
DCLRE1B	64858	broad.mit.edu	37	1	114454019	114454019	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114454019C>A	uc001eeg.2	+	4	976	c.805C>A	c.(805-807)CAC>AAC	p.H269N	DCLRE1B_uc001eeh.2_Missense_Mutation_p.H143N|DCLRE1B_uc001eei.2_Missense_Mutation_p.H143N	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	269					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)									Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
CSDE1	7812	broad.mit.edu	37	1	115263150	115263150	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115263150T>C	uc001efk.2	-						CSDE1_uc001efi.2_Intron|CSDE1_uc001efj.2_Intron|CSDE1_uc001efl.2_Intron|CSDE1_uc001efm.2_Intron|CSDE1_uc009wgv.2_Intron|CSDE1_uc001efn.2_Intron	NM_001007553	NP_001007554			upstream of NRAS isoform 1						male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
NGF	4803	broad.mit.edu	37	1	115828975	115828975	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115828975T>C	uc001efu.1	-	3	611	c.442A>G	c.(442-444)ACC>GCC	p.T148A		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	148					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)													---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117122169	117122169	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117122169G>A	uc001egr.1	-	10	3884	c.3179C>T	c.(3178-3180)CCG>CTG	p.P1060L	IGSF3_uc001egq.1_Missense_Mutation_p.P1080L	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	1060	Ig-like C2-type 8.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117156447	117156447	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117156447A>G	uc001egr.1	-	4	1477	c.772T>C	c.(772-774)TCG>CCG	p.S258P	IGSF3_uc001egq.1_Missense_Mutation_p.S258P	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	258	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
CD2	914	broad.mit.edu	37	1	117297441	117297441	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117297441T>C	uc001egu.3	+	2	279	c.250T>C	c.(250-252)TAT>CAT	p.Y84H	CD2_uc010owz.1_Missense_Mutation_p.Y84H|CD2_uc010oxa.1_Missense_Mutation_p.Y84H	NM_001767	NP_001758	P06729	CD2_HUMAN	CD2 molecule precursor	84	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			breast(1)	1	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)													---	---	---	---
CD101	9398	broad.mit.edu	37	1	117564494	117564494	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117564494C>T	uc010oxb.1	+	7	2375	c.2317C>T	c.(2317-2319)CGG>TGG	p.R773W	CD101_uc009whd.2_Missense_Mutation_p.R773W|CD101_uc010oxc.1_Missense_Mutation_p.R773W|CD101_uc010oxd.1_Missense_Mutation_p.R711W	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	773	Ig-like C2-type 6.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4																		---	---	---	---
TTF2	8458	broad.mit.edu	37	1	117619362	117619362	+	Missense_Mutation	SNP	G	A	A	rs139705346	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117619362G>A	uc001egy.2	+	7	1510	c.1490G>A	c.(1489-1491)CGT>CAT	p.R497H	TTF2_uc001egx.1_Missense_Mutation_p.R497H	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	497					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)														---	---	---	---
TRIM45	80263	broad.mit.edu	37	1	117658232	117658232	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117658232T>C	uc001egz.2	-	4	2020	c.1432A>G	c.(1432-1434)ACT>GCT	p.T478A	TRIM45_uc009whe.2_Missense_Mutation_p.T460A|TRIM45_uc001eha.2_Missense_Mutation_p.T374A	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	478	Filamin.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)														---	---	---	---
SPAG17	200162	broad.mit.edu	37	1	118530776	118530776	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118530776T>C	uc001ehk.2	-	39	5641	c.5573A>G	c.(5572-5574)AAA>AGA	p.K1858R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1858						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)														---	---	---	---
WARS2	10352	broad.mit.edu	37	1	119575743	119575743	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:119575743G>A	uc001ehn.2	-	6	902	c.874C>T	c.(874-876)CGC>TGC	p.R292C	WARS2_uc010oxf.1_Missense_Mutation_p.R198C|WARS2_uc001ehm.2_3'UTR|WARS2_uc010oxg.1_Missense_Mutation_p.R235C|WARS2_uc010oxh.1_3'UTR	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	292					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)													---	---	---	---
REG4	83998	broad.mit.edu	37	1	120341118	120341118	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120341118A>G	uc001eig.2	-	6	849	c.409_splice	c.e6+1	p.N137_splice	REG4_uc001eif.2_Splice_Site_p.N137_splice	NM_001159352	NP_001152824			regenerating islet-derived family, member 4							extracellular region	sugar binding			ovary(1)	1	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)														---	---	---	---
NOTCH2	4853	broad.mit.edu	37	1	120458677	120458677	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120458677T>C	uc001eik.2	-	34	6924	c.6668A>G	c.(6667-6669)CAG>CGG	p.Q2223R		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	2223	Cytoplasmic (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)				N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---	---
PDE4DIP	9659	broad.mit.edu	37	1	144931587	144931587	+	Intron	SNP	A	G	G	rs79448580		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144931587A>G	uc001elw.3	-						NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001emc.1_Intron|PDE4DIP_uc001emd.1_Intron|PDE4DIP_uc001emb.1_Missense_Mutation_p.V41A|PDE4DIP_uc001emf.1_Intron	NM_014644	NP_055459			phosphodiesterase 4D interacting protein isoform						cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)				T	PDGFRB	MPD								---	---	---	---
HFE2	148738	broad.mit.edu	37	1	145415465	145415465	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145415465G>A	uc001eni.2	+	3	609	c.284G>A	c.(283-285)CGC>CAC	p.R95H	NBPF10_uc001emp.3_Intron|HFE2_uc001enj.2_Intron|HFE2_uc001enk.2_5'UTR|HFE2_uc001enl.2_Intron	NM_213653	NP_998818	Q6ZVN8	RGMC_HUMAN	hemojuvelin isoform a precursor	95					axon guidance	anchored to membrane				ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)																	---	---	---	---
ITGA10	8515	broad.mit.edu	37	1	145534184	145534184	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145534184T>C	uc001eoa.2	+	14	1765	c.1689T>C	c.(1687-1689)GGT>GGC	p.G563G	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.G432G|ITGA10_uc009wiw.2_Silent_p.G420G|ITGA10_uc010oyw.1_Silent_p.G508G	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	563	Potential.|Extracellular (Potential).|FG-GAP 6.				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)																	---	---	---	---
BCL9	607	broad.mit.edu	37	1	147096052	147096052	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:147096052A>G	uc001epq.2	+	10	4313	c.3573A>G	c.(3571-3573)GCA>GCG	p.A1191A	BCL9_uc010ozr.1_Silent_p.A1105A	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1191	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)							T	IGH@|IGL@	B-ALL								---	---	---	---
ACP6	51205	broad.mit.edu	37	1	147120182	147120182	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:147120182T>C	uc001epr.2	-	9	1473	c.1009A>G	c.(1009-1011)ACC>GCC	p.T337A		NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	337					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)																	---	---	---	---
HIST2H2AC	8338	broad.mit.edu	37	1	149858893	149858893	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149858893C>T	uc001etd.2	+	1	369	c.369C>T	c.(367-369)AGC>AGT	p.S123S	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	123					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)															---	---	---	---
HIST2H2AB	317772	broad.mit.edu	37	1	149859204	149859204	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149859204A>G	uc001ete.2	-	1	263	c.263T>C	c.(262-264)GTG>GCG	p.V88A	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	88					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)															---	---	---	---
SF3B4	10262	broad.mit.edu	37	1	149897720	149897720	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:149897720A>G	uc001etj.1	-						SF3B4_uc001eti.1_Intron|SF3B4_uc001etk.1_Intron|SF3B4_uc009wll.1_Silent_p.C307C	NM_005850	NP_005841			splicing factor 3b, subunit 4							nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)															---	---	---	---
CA14	23632	broad.mit.edu	37	1	150235560	150235560	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150235560A>G	uc001etx.2	+	7	991	c.682A>G	c.(682-684)ACA>GCA	p.T228A		NM_012113	NP_036245	Q9ULX7	CAH14_HUMAN	carbonic anhydrase XIV precursor	228	Extracellular (Potential).					integral to membrane	carbonate dehydratase activity|metal ion binding			ovary(1)	1	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
RPRD2	23248	broad.mit.edu	37	1	150445370	150445370	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150445370G>A	uc009wlr.2	+	11	4147	c.3946G>A	c.(3946-3948)GGA>AGA	p.G1316R	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.G1290R	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1316	Pro-rich.						protein binding			ovary(1)	1																		---	---	---	---
ECM1	1893	broad.mit.edu	37	1	150482127	150482127	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150482127T>C	uc001eus.2	+						ECM1_uc010pce.1_Intron|ECM1_uc010pcf.1_Intron|ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Intron|ECM1_uc001euv.2_Intron|ECM1_uc009wlu.2_Intron	NM_004425	NP_004416			extracellular matrix protein 1 isoform 1						angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)															---	---	---	---
ECM1	1893	broad.mit.edu	37	1	150484269	150484269	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150484269T>C	uc001eus.2	+	7	1244	c.1045T>C	c.(1045-1047)TGC>CGC	p.C349R	ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Missense_Mutation_p.C378R|ECM1_uc001euv.2_Missense_Mutation_p.C376R|ECM1_uc009wlu.2_Missense_Mutation_p.C109R	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	349	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)															---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150931668	150931668	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150931668A>G	uc001evu.2	+	15	2535	c.2345A>G	c.(2344-2346)AAC>AGC	p.N782S	SETDB1_uc001evv.2_Missense_Mutation_p.N782S|SETDB1_uc009wmg.1_Missense_Mutation_p.N782S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	782	Pre-SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150933482	150933482	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150933482G>A	uc001evu.2	+	16	3134	c.2944G>A	c.(2944-2946)GCC>ACC	p.A982T	SETDB1_uc001evv.2_Missense_Mutation_p.A982T|SETDB1_uc009wmg.1_Missense_Mutation_p.A982T	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	982	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
BNIPL	149428	broad.mit.edu	37	1	151011305	151011305	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151011305G>A	uc001ewl.2	+	4	409	c.236G>A	c.(235-237)GGC>GAC	p.G79D	BNIPL_uc009wmi.2_5'UTR|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	79					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
SEMA6C	10500	broad.mit.edu	37	1	151109535	151109535	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151109535C>T	uc001ewu.2	-	11	1072	c.772G>A	c.(772-774)GTA>ATA	p.V258I	SEMA6C_uc001ewv.2_Missense_Mutation_p.V258I|SEMA6C_uc001eww.2_Missense_Mutation_p.V218I|SEMA6C_uc010pcq.1_Missense_Mutation_p.V258I|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	258	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
ZNF687	57592	broad.mit.edu	37	1	151259923	151259923	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151259923G>C	uc001exq.2	+	2	1254	c.1156G>C	c.(1156-1158)GTG>CTG	p.V386L	ZNF687_uc001exp.1_Missense_Mutation_p.V395L|ZNF687_uc009wmo.2_Missense_Mutation_p.V386L|ZNF687_uc009wmp.2_Missense_Mutation_p.V386L	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
PSMB4	5692	broad.mit.edu	37	1	151372168	151372168	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151372168G>A	uc001eyc.1	+	1	128	c.105G>A	c.(103-105)GCG>GCA	p.A35A	PSMB4_uc010pda.1_Silent_p.A35A|PSMB4_uc001eyb.1_Silent_p.A35A	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	35					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
LINGO4	339398	broad.mit.edu	37	1	151774479	151774479	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151774479C>T	uc001ezf.1	-	2	892	c.702G>A	c.(700-702)GAG>GAA	p.E234E		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	234	Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
RPTN	126638	broad.mit.edu	37	1	152129190	152129190	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152129190T>C	uc001ezs.1	-	3	450	c.385A>G	c.(385-387)AGG>GGG	p.R129G		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	129	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0																		---	---	---	---
FLG	2312	broad.mit.edu	37	1	152278828	152278828	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152278828T>C	uc001ezu.1	-	3	8570	c.8534A>G	c.(8533-8535)GAA>GGA	p.E2845G		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2845	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)											Ichthyosis				---	---	---	---
FLG	2312	broad.mit.edu	37	1	152282840	152282840	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152282840A>T	uc001ezu.1	-	3	4558	c.4522T>A	c.(4522-4524)TCA>ACA	p.S1508T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1508	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)											Ichthyosis				---	---	---	---
FLG2	388698	broad.mit.edu	37	1	152326143	152326143	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152326143A>G	uc001ezw.3	-	3	4192	c.4119T>C	c.(4117-4119)GCT>GCC	p.A1373A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1373							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
FLG2	388698	broad.mit.edu	37	1	152326301	152326301	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152326301T>C	uc001ezw.3	-	3	4034	c.3961A>G	c.(3961-3963)ACC>GCC	p.T1321A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1321							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
LCE2C	353140	broad.mit.edu	37	1	152648551	152648551	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:152648551T>C	uc001fah.2	+	2	115	c.60T>C	c.(58-60)TGT>TGC	p.C20C		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	20	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)															---	---	---	---
NPR1	4881	broad.mit.edu	37	1	153659753	153659753	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153659753C>A	uc001fcs.3	+	13	2434	c.2013C>A	c.(2011-2013)CGC>CGA	p.R671R	NPR1_uc010pdz.1_Silent_p.R417R|NPR1_uc010pea.1_Silent_p.R149R	NM_000906	NP_000897	P16066	ANPRA_HUMAN	natriuretic peptide receptor 1 precursor	671	Cytoplasmic (Potential).|Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			ovary(3)|lung(2)|stomach(1)|breast(1)	7	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)													---	---	---	---
DENND4B	9909	broad.mit.edu	37	1	153908639	153908639	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153908639A>G	uc001fdd.1	-	17	2866	c.2465T>C	c.(2464-2466)CTC>CCC	p.L822P		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	822	PPR 2.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
RAB13	5872	broad.mit.edu	37	1	153955025	153955025	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153955025T>C	uc001fdt.1	-	6	560	c.466A>G	c.(466-468)ATG>GTG	p.M156V	RAB13_uc001fdu.1_3'UTR	NM_002870	NP_002861	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	156					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
C1orf43	25912	broad.mit.edu	37	1	154185068	154185068	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154185068G>A	uc001fei.2	-	5	763	c.373C>T	c.(373-375)CGT>TGT	p.R125C	C1orf43_uc001fef.1_Missense_Mutation_p.R22C|C1orf43_uc001feg.2_Missense_Mutation_p.R91C|C1orf43_uc001feh.2_Missense_Mutation_p.R73C|C1orf43_uc001fej.2_Missense_Mutation_p.R107C|C1orf43_uc009wos.1_Missense_Mutation_p.R107C|C1orf43_uc001fek.2_Missense_Mutation_p.R125C|C1orf43_uc001fel.2_Missense_Mutation_p.R91C	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	125						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)																	---	---	---	---
UBAP2L	9898	broad.mit.edu	37	1	154199796	154199796	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154199796G>A	uc001fep.3	+	3	296	c.129G>A	c.(127-129)TCG>TCA	p.S43S	UBAP2L_uc009wot.2_Silent_p.S43S|UBAP2L_uc010pek.1_Silent_p.S42S|UBAP2L_uc010pel.1_Silent_p.S42S|UBAP2L_uc001fen.1_Silent_p.S42S|UBAP2L_uc010pem.1_Silent_p.S42S|UBAP2L_uc010pen.1_5'Flank	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	43					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
HAX1	10456	broad.mit.edu	37	1	154246038	154246038	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154246038G>A	uc001fes.2	+	2	441	c.280G>A	c.(280-282)GAT>AAT	p.D94N	HAX1_uc001fet.2_Missense_Mutation_p.D46N|HAX1_uc010peo.1_Missense_Mutation_p.D94N|HAX1_uc009wou.2_5'UTR|HAX1_uc009wov.2_Missense_Mutation_p.D68N	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	94						actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)											Kostmann_syndrome				---	---	---	---
HAX1	10456	broad.mit.edu	37	1	154246292	154246292	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154246292G>A	uc001fes.2	+	3	520	c.359G>A	c.(358-360)CGG>CAG	p.R120Q	HAX1_uc001fet.2_Missense_Mutation_p.R72Q|HAX1_uc010peo.1_Missense_Mutation_p.R128Q|HAX1_uc009wou.2_Missense_Mutation_p.R45Q|HAX1_uc009wov.2_Missense_Mutation_p.R94Q	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	120	Involved in HCLS1 binding.					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)											Kostmann_syndrome				---	---	---	---
SHE	126669	broad.mit.edu	37	1	154458516	154458516	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154458516G>A	uc001ffb.2	-	5	1291	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	402	SH2.									breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
UBE2Q1	55585	broad.mit.edu	37	1	154524643	154524643	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154524643C>T	uc001fff.1	-	8	983	c.892G>A	c.(892-894)GCT>ACT	p.A298T		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	298							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
UBE2Q1	55585	broad.mit.edu	37	1	154525264	154525264	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154525264G>A	uc001fff.1	-	6	853	c.762C>T	c.(760-762)GAC>GAT	p.D254D		NM_017582	NP_060052	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q	254							ATP binding|protein binding|ubiquitin-protein ligase activity				0	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
ADAR	103	broad.mit.edu	37	1	154569432	154569432	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154569432A>T	uc001ffh.2	-	6	2319	c.2119T>A	c.(2119-2121)TCC>ACC	p.S707T	ADAR_uc001ffj.2_Intron|ADAR_uc001ffi.2_Missense_Mutation_p.S707T|ADAR_uc001ffk.2_Missense_Mutation_p.S412T	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	707					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)														---	---	---	---
ADAR	103	broad.mit.edu	37	1	154600361	154600361	+	5'UTR	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154600361G>C	uc001ffk.2	-	1						NM_001025107	NP_001020278			adenosine deaminase, RNA-specific isoform d						adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)														---	---	---	---
PYGO2	90780	broad.mit.edu	37	1	154931981	154931981	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154931981T>C	uc001fft.2	-	3	701	c.495A>G	c.(493-495)CAA>CAG	p.Q165Q		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	165	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
FLAD1	80308	broad.mit.edu	37	1	154960959	154960959	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154960959G>A	uc001fgf.1	+	2	1105	c.751G>A	c.(751-753)GTC>ATC	p.V251I	FLAD1_uc001fgc.2_Missense_Mutation_p.V152I|FLAD1_uc001fgd.1_Missense_Mutation_p.V251I|FLAD1_uc001fge.1_Missense_Mutation_p.V154I|FLAD1_uc001fgg.1_Missense_Mutation_p.V154I|FLAD1_uc001fgh.1_5'UTR	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	251					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)															---	---	---	---
THBS3	7059	broad.mit.edu	37	1	155170773	155170773	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155170773T>C	uc001fix.2	-	13	1486	c.1463A>G	c.(1462-1464)AAC>AGC	p.N488S	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Missense_Mutation_p.N479S|THBS3_uc001fiz.2_Missense_Mutation_p.N451S|THBS3_uc001fiy.2_Missense_Mutation_p.N17S|THBS3_uc010pfu.1_Missense_Mutation_p.N368S|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	488	TSP type-3 1.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
HCN3	57657	broad.mit.edu	37	1	155255658	155255658	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155255658C>T	uc001fjz.1	+	6	1388	c.1380C>T	c.(1378-1380)TCC>TCT	p.S460S	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Silent_p.S155S	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	460	Cytoplasmic (Potential).|cAMP.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
RUSC1	23623	broad.mit.edu	37	1	155292385	155292385	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155292385A>G	uc001fkj.2	+	2	1050	c.821A>G	c.(820-822)GAC>GGC	p.D274G	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_5'Flank|C1orf104_uc001fki.2_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.D274G|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank|RUSC1_uc001fkp.2_5'Flank|RUSC1_uc001fkq.2_5'Flank|RUSC1_uc010pgb.1_5'Flank|RUSC1_uc009wqp.1_5'Flank|RUSC1_uc001fkn.2_5'Flank|RUSC1_uc001fko.2_5'Flank|RUSC1_uc001fkr.2_5'Flank|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	274						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)															---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155491319	155491319	+	Translation_Start_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155491319T>C	uc009wqq.2	-	2	472	c.-8A>G	c.(-10--6)ATACG>ATGCG		ASH1L_uc001fkt.2_Translation_Start_Site|ASH1L_uc009wqr.1_Translation_Start_Site	NM_018489	NP_060959			absent, small, or homeotic 1-like						cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
LMNA	4000	broad.mit.edu	37	1	156108471	156108471	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156108471G>A	uc001fni.2	+	11	2140	c.1891G>A	c.(1891-1893)GGC>AGC	p.G631S	LMNA_uc001fnf.1_3'UTR|LMNA_uc001fnh.2_Missense_Mutation_p.G601S|LMNA_uc009wro.1_Intron|LMNA_uc001fnj.2_3'UTR|LMNA_uc001fnk.2_Missense_Mutation_p.G532S|LMNA_uc010pha.1_3'UTR|LMNA_uc010phb.1_RNA	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	631	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)													Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				---	---	---	---
SLC25A44	9673	broad.mit.edu	37	1	156170077	156170077	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156170077G>A	uc001fnp.2	+	2	761	c.439G>A	c.(439-441)GGC>AGC	p.G147S	SLC25A44_uc010phc.1_Intron|SLC25A44_uc009wrr.2_Missense_Mutation_p.G147S|SLC25A44_uc010phd.1_Intron|SLC25A44_uc010phe.1_Intron	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	147	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)																	---	---	---	---
PAQR6	79957	broad.mit.edu	37	1	156214025	156214025	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156214025T>C	uc001fnu.1	-	8	1000	c.930A>G	c.(928-930)CTA>CTG	p.L310L	PAQR6_uc010phf.1_Missense_Mutation_p.Y160C|PAQR6_uc001fny.1_Missense_Mutation_p.Y88C|PAQR6_uc001fnv.1_Silent_p.L286L|PAQR6_uc010phg.1_Silent_p.L307L|PAQR6_uc001fnx.1_Silent_p.L204L|PAQR6_uc001fnw.1_Missense_Mutation_p.Y228C|PAQR6_uc001fnz.1_Missense_Mutation_p.Y228C|PAQR6_uc010phh.1_Silent_p.L310L|PAQR6_uc001foa.1_Silent_p.L204L|PAQR6_uc001fob.1_RNA	NM_198406	NP_940798	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	310	Helical; (Potential).					integral to membrane	receptor activity				0	Hepatocellular(266;0.158)																	---	---	---	---
RHBG	57127	broad.mit.edu	37	1	156351209	156351209	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156351209C>T	uc010pho.1	+	5	783	c.745C>T	c.(745-747)CGG>TGG	p.R249W	RHBG_uc010phm.1_Missense_Mutation_p.R87W|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Missense_Mutation_p.R180W|RHBG_uc009wrz.2_Missense_Mutation_p.R217W|RHBG_uc001for.2_Missense_Mutation_p.R219W	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	249	Extracellular (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)																	---	---	---	---
MEF2D	4209	broad.mit.edu	37	1	156452281	156452281	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156452281T>C	uc001fpc.2	-	3	596	c.206A>G	c.(205-207)TAC>TGC	p.Y69C	MEF2D_uc001fpb.2_Missense_Mutation_p.Y69C|MEF2D_uc001fpd.2_Missense_Mutation_p.Y69C|MEF2D_uc001fpe.1_Missense_Mutation_p.Y69C|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	69	Mef2-type (Potential).				apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
IQGAP3	128239	broad.mit.edu	37	1	156499967	156499967	+	Missense_Mutation	SNP	C	T	T	rs149623112	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156499967C>T	uc001fpf.2	-	34	4409	c.4334G>A	c.(4333-4335)CGC>CAC	p.R1445H		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1445					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
IQGAP3	128239	broad.mit.edu	37	1	156499976	156499976	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156499976C>T	uc001fpf.2	-	34	4400	c.4325G>A	c.(4324-4326)CGG>CAG	p.R1442Q		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1442					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
IQGAP3	128239	broad.mit.edu	37	1	156517928	156517928	+	Silent	SNP	C	T	T	rs151288646		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156517928C>T	uc001fpf.2	-	19	2316	c.2241G>A	c.(2239-2241)CGG>CGA	p.R747R		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	747	IQ 1.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
IQGAP3	128239	broad.mit.edu	37	1	156532379	156532379	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156532379C>T	uc001fpf.2	-	9	952	c.877G>A	c.(877-879)GTC>ATC	p.V293I	IQGAP3_uc009wsb.1_Missense_Mutation_p.V250I	NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	293					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
ARHGEF11	9826	broad.mit.edu	37	1	156955924	156955924	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156955924C>T	uc001fqo.2	-	2	1114	c.74G>A	c.(73-75)CGC>CAC	p.R25H	ARHGEF11_uc001fqn.2_Missense_Mutation_p.R25H	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	25					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)																	---	---	---	---
CD1C	911	broad.mit.edu	37	1	158263003	158263003	+	Silent	SNP	A	G	G	rs114722992	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158263003A>G	uc001fru.2	+	5	1183	c.891A>G	c.(889-891)GGA>GGG	p.G297G	CD1C_uc001frv.2_Intron	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	297	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)																	---	---	---	---
OR6K2	81448	broad.mit.edu	37	1	158670434	158670434	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158670434G>T	uc001fsu.1	-	1	9	c.9C>A	c.(7-9)AGC>AGA	p.S3R		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)																	---	---	---	---
OR6K3	391114	broad.mit.edu	37	1	158687161	158687161	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158687161T>A	uc010pip.1	-	1	793	c.793A>T	c.(793-795)ATA>TTA	p.I265L		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	265	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)																	---	---	---	---
OR6K3	391114	broad.mit.edu	37	1	158687464	158687464	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158687464A>G	uc010pip.1	-	1	490	c.490T>C	c.(490-492)TCC>CCC	p.S164P		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)																	---	---	---	---
CADM3	57863	broad.mit.edu	37	1	159163707	159163707	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159163707G>A	uc001ftl.2	+	5	710	c.568G>A	c.(568-570)GTC>ATC	p.V190I	CADM3_uc009wsy.1_Intron|CADM3_uc001ftk.2_Missense_Mutation_p.V224I	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	190	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)																	---	---	---	---
OR10J3	441911	broad.mit.edu	37	1	159284344	159284344	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159284344A>G	uc010piu.1	-	1	106	c.106T>C	c.(106-108)TAC>CAC	p.Y36H		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)																	---	---	---	---
FCRL6	343413	broad.mit.edu	37	1	159780002	159780002	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159780002A>C	uc001fud.3	+	6	1047	c.1005A>C	c.(1003-1005)AAA>AAC	p.K335N	FCRL6_uc001fuc.2_Missense_Mutation_p.K342N|FCRL6_uc009wsz.1_Missense_Mutation_p.K240N|FCRL6_uc009wta.2_Missense_Mutation_p.K335N	NM_001004310	NP_001004310	Q6DN72	FCRL6_HUMAN	Fc receptor-like 6 precursor	335	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.0597)																	---	---	---	---
VSIG8	391123	broad.mit.edu	37	1	159827580	159827580	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:159827580A>T	uc001fuh.2	-	4	743	c.607T>A	c.(607-609)TCA>ACA	p.S203T	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	203	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)																	---	---	---	---
IGSF8	93185	broad.mit.edu	37	1	160063696	160063696	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160063696C>A	uc001fva.2	-	3	753	c.708G>T	c.(706-708)GAG>GAT	p.E236D	IGSF8_uc001fuz.2_Missense_Mutation_p.E236D|IGSF8_uc009wtf.2_Missense_Mutation_p.E236D	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	236	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)															---	---	---	---
ATP1A4	480	broad.mit.edu	37	1	160134082	160134082	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160134082G>T	uc001fve.3	+	7	1394	c.915G>T	c.(913-915)GTG>GTT	p.V305V	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_5'Flank	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	305	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
COPA	1314	broad.mit.edu	37	1	160267456	160267456	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160267456T>C	uc009wti.2	-	20	2451	c.2057A>G	c.(2056-2058)AAC>AGC	p.N686S	COPA_uc001fvv.3_Missense_Mutation_p.N695S	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	686					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
COPA	1314	broad.mit.edu	37	1	160268702	160268702	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160268702A>G	uc009wti.2	-	19	2304	c.1910T>C	c.(1909-1911)GTG>GCG	p.V637A	COPA_uc001fvv.3_Missense_Mutation_p.V646A	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	637					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
COPA	1314	broad.mit.edu	37	1	160276963	160276963	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160276963C>T	uc009wti.2	-	14	1686	c.1292G>A	c.(1291-1293)CGG>CAG	p.R431Q	COPA_uc001fvv.3_Missense_Mutation_p.R431Q|COPA_uc009wtj.1_Missense_Mutation_p.R377Q	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	431					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
NCSTN	23385	broad.mit.edu	37	1	160320035	160320035	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160320035A>G	uc001fvx.2	+	5	701	c.577A>G	c.(577-579)AAG>GAG	p.K193E	NCSTN_uc001fvy.2_Missense_Mutation_p.K173E|NCSTN_uc010pjf.1_Missense_Mutation_p.K193E|NCSTN_uc001fvz.2_5'UTR|NCSTN_uc010pjg.1_5'UTR	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	193	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
SLAMF7	57823	broad.mit.edu	37	1	160718018	160718018	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160718018C>T	uc001fwq.2	+	2	105	c.90C>T	c.(88-90)GTC>GTT	p.V30V	SLAMF7_uc010pjn.1_Intron|SLAMF7_uc001fws.2_Intron|SLAMF7_uc001fwr.2_Silent_p.V30V|SLAMF7_uc010pjo.1_Silent_p.V30V|SLAMF7_uc010pjp.1_Intron|SLAMF7_uc010pjq.1_Silent_p.V30V|SLAMF7_uc010pjr.1_Intron	NM_021181	NP_067004	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	30	Extracellular (Potential).				cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			skin(2)|ovary(1)	3	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)															---	---	---	---
ITLN2	142683	broad.mit.edu	37	1	160917764	160917764	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160917764G>A	uc001fxd.2	-	7	838	c.780C>T	c.(778-780)AAC>AAT	p.N260N	ITLN2_uc009wts.2_Silent_p.N259N|ITLN2_uc010pju.1_Silent_p.N177N	NM_080878	NP_543154	Q8WWU7	ITLN2_HUMAN	intelectin 2 precursor	260	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			ovary(1)	1	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)															---	---	---	---
KLHDC9	126823	broad.mit.edu	37	1	161070003	161070003	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161070003G>A	uc001fxr.2	+	4	1211	c.1039G>A	c.(1039-1041)GAC>AAC	p.D347N	KLHDC9_uc001fxq.2_Missense_Mutation_p.D109N|KLHDC9_uc001fxs.2_3'UTR	NM_152366	NP_689579	Q8NEP7	KLDC9_HUMAN	kelch/ankyrin repeat containing cyclin A1	347	Kelch 3.										0	all_cancers(52;1.28e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)															---	---	---	---
FCGR2C	9103	broad.mit.edu	37	1	161559418	161559418	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161559418T>C	uc001gav.2	+	4	299	c.200T>C	c.(199-201)GTG>GCG	p.V67A	FCGR2C_uc009wuj.2_RNA|FCGR2C_uc009wuk.2_RNA	NM_201563	NP_963857			Fc fragment of IgG, low affinity IIc, receptor												0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)															---	---	---	---
NUF2	83540	broad.mit.edu	37	1	163315530	163315530	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163315530G>T	uc001gcq.1	+	11	1170	c.870G>T	c.(868-870)CAG>CAT	p.Q290H	NUF2_uc001gcp.2_Missense_Mutation_p.Q290H|NUF2_uc001gcr.1_Missense_Mutation_p.Q290H|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	290	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)																	---	---	---	---
RXRG	6258	broad.mit.edu	37	1	165386317	165386317	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165386317G>A	uc001gda.2	-	4	883	c.583C>T	c.(583-585)CGC>TGC	p.R195C		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	195	NR C4-type.|Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)													---	---	---	---
ALDH9A1	223	broad.mit.edu	37	1	165632366	165632366	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165632366T>C	uc001gdh.1	-	11	1583	c.1478A>G	c.(1477-1479)AAC>AGC	p.N493S	ALDH9A1_uc010pky.1_Missense_Mutation_p.N399S|ALDH9A1_uc010pkz.1_Missense_Mutation_p.N483S	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	469					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)													---	---	---	---
TADA1	117143	broad.mit.edu	37	1	166838708	166838708	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166838708C>T	uc001gdw.2	-	3	390	c.206G>A	c.(205-207)CGT>CAT	p.R69H	TADA1_uc009wve.2_Missense_Mutation_p.R69H	NM_053053	NP_444281	Q96BN2	TADA1_HUMAN	transcriptional adaptor 1-like	69					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(1)	1																		---	---	---	---
ILDR2	387597	broad.mit.edu	37	1	166927241	166927241	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:166927241G>T	uc001gdx.1	-	2	200	c.144C>A	c.(142-144)TCC>TCA	p.S48S		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	48	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1																		---	---	---	---
DUSP27	92235	broad.mit.edu	37	1	167095407	167095407	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:167095407G>A	uc001geb.1	+	5	1039	c.1039G>A	c.(1039-1041)GAG>AAG	p.E347K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	347					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3																		---	---	---	---
SELL	6402	broad.mit.edu	37	1	169677585	169677585	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169677585T>C	uc001ggk.2	-	3	643	c.445A>G	c.(445-447)AAA>GAA	p.K149E	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Missense_Mutation_p.K102E|SELL_uc001ggl.1_Missense_Mutation_p.K162E	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	149	C-type lectin.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)																	---	---	---	---
SELE	6401	broad.mit.edu	37	1	169701051	169701051	+	Missense_Mutation	SNP	C	T	T	rs143566739		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169701051C>T	uc001ggm.3	-	4	611	c.454G>A	c.(454-456)GGT>AGT	p.G152S	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	152	EGF-like.|Extracellular (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)																	---	---	---	---
C1orf112	55732	broad.mit.edu	37	1	169771846	169771846	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169771846A>G	uc001ggp.2	+	5	461	c.151A>G	c.(151-153)ACT>GCT	p.T51A	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggo.2_Missense_Mutation_p.T51A|C1orf112_uc001ggq.2_Missense_Mutation_p.T51A|C1orf112_uc009wvt.2_5'UTR|C1orf112_uc010plu.1_Missense_Mutation_p.T22A|C1orf112_uc009wvu.1_Missense_Mutation_p.T22A|C1orf112_uc001ggr.2_5'UTR|C1orf112_uc010plv.1_5'Flank	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	51											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
C1orf112	55732	broad.mit.edu	37	1	169772333	169772333	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169772333T>G	uc001ggp.2	+	6	505	c.195T>G	c.(193-195)GCT>GCG	p.A65A	C1orf112_uc001ggj.2_RNA|C1orf112_uc001ggo.2_Silent_p.A65A|C1orf112_uc001ggq.2_Silent_p.A65A|C1orf112_uc009wvt.2_5'UTR|C1orf112_uc010plu.1_Silent_p.A36A|C1orf112_uc009wvu.1_Silent_p.A36A|C1orf112_uc001ggr.2_5'UTR|C1orf112_uc010plv.1_Silent_p.A7A	NM_018186	NP_060656	Q9NSG2	CA112_HUMAN	hypothetical protein LOC55732	65											0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
PRRX1	5396	broad.mit.edu	37	1	170695482	170695482	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:170695482T>C	uc001ghf.2	+	3	586	c.539T>C	c.(538-540)GTA>GCA	p.V180A	PRRX1_uc001ghe.2_Missense_Mutation_p.V180A	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	180						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.V180I(1)		ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
PRRX1	5396	broad.mit.edu	37	1	170695497	170695497	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:170695497C>T	uc001ghf.2	+	3	601	c.554C>T	c.(553-555)CCG>CTG	p.P185L	PRRX1_uc001ghe.2_Missense_Mutation_p.P185L	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	185						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
C1orf9	51430	broad.mit.edu	37	1	172526937	172526937	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172526937A>G	uc001giq.3	+						C1orf9_uc010pmm.1_Intron|C1orf9_uc009wwd.2_Intron|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098			chromosome 1 open reading frame 9 protein						multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)														---	---	---	---
C1orf9	51430	broad.mit.edu	37	1	172558159	172558159	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172558159A>G	uc001giq.3	+	18	2234	c.1918A>G	c.(1918-1920)AGA>GGA	p.R640G	C1orf9_uc010pmm.1_Missense_Mutation_p.R640G|C1orf9_uc009wwd.2_Missense_Mutation_p.R596G|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	640					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)														---	---	---	---
SLC9A11	284525	broad.mit.edu	37	1	173499145	173499145	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173499145G>A	uc001giz.2	-	18	2635	c.2212C>T	c.(2212-2214)CGC>TGC	p.R738C	SLC9A11_uc009wwe.2_Missense_Mutation_p.R296C|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	738					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
KLHL20	27252	broad.mit.edu	37	1	173726131	173726131	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173726131T>C	uc001gjc.2	+	7	1163	c.984T>C	c.(982-984)AGT>AGC	p.S328S	KLHL20_uc010pmr.1_Silent_p.S139S|KLHL20_uc009wwf.2_Silent_p.S310S	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	328	Kelch 1.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
CACYBP	27101	broad.mit.edu	37	1	174975919	174975919	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174975919A>G	uc001gkj.1	+	3	699	c.274A>G	c.(274-276)ACC>GCC	p.T92A	CACYBP_uc001gki.1_Missense_Mutation_p.T49A	NM_014412	NP_055227	Q9HB71	CYBP_HUMAN	calcyclin binding protein isoform 1	92	Interaction with SKP1.|CS.					beta-catenin destruction complex	protein homodimerization activity				0																		---	---	---	---
MRPS14	63931	broad.mit.edu	37	1	174987603	174987603	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174987603A>G	uc001gkk.2	-	2	172	c.155T>C	c.(154-156)CTA>CCA	p.L52P	MRPS14_uc009wwr.2_Missense_Mutation_p.L37P	NM_022100	NP_071383	O60783	RT14_HUMAN	mitochondrial ribosomal protein S14	52					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome				0																		---	---	---	---
TNN	63923	broad.mit.edu	37	1	175087805	175087805	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175087805C>T	uc001gkl.1	+	11	2608	c.2495C>T	c.(2494-2496)ACG>ATG	p.T832M		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	832	Fibronectin type-III 7.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)														---	---	---	---
TNN	63923	broad.mit.edu	37	1	175113675	175113675	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175113675A>G	uc001gkl.1	+	18	3861	c.3748A>G	c.(3748-3750)AAG>GAG	p.K1250E		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	1250	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)														---	---	---	---
TNR	7143	broad.mit.edu	37	1	175299227	175299227	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175299227C>T	uc001gkp.1	-	19	3857	c.3776G>A	c.(3775-3777)AGC>AAC	p.S1259N	TNR_uc009wwu.1_Missense_Mutation_p.S1259N	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1259	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)																	---	---	---	---
TNR	7143	broad.mit.edu	37	1	175299353	175299353	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175299353C>A	uc001gkp.1	-	19	3731	c.3650G>T	c.(3649-3651)AGG>ATG	p.R1217M	TNR_uc009wwu.1_Missense_Mutation_p.R1217M	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1217	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)																	---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	176085813	176085813	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176085813T>C	uc001gku.1	-	9	1229	c.973A>G	c.(973-975)ATT>GTT	p.I325V	RFWD2_uc001gkv.1_Missense_Mutation_p.I301V|RFWD2_uc001gkw.1_Missense_Mutation_p.I85V|RFWD2_uc009wwv.2_Missense_Mutation_p.I85V|RFWD2_uc001gkt.1_Missense_Mutation_p.I164V	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	325					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	176145092	176145092	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176145092A>G	uc001gku.1	-	3	775	c.519T>C	c.(517-519)TGT>TGC	p.C173C	RFWD2_uc001gkv.1_Silent_p.C173C|RFWD2_uc001gkw.1_5'UTR|RFWD2_uc001gkt.1_Silent_p.C32C	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	173	RING-type.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176563808	176563808	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176563808C>T	uc001gkz.2	+	3	2232	c.1068C>T	c.(1066-1068)CAC>CAT	p.H356H	PAPPA2_uc001gky.1_Silent_p.H356H|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	356					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
FAM5B	57795	broad.mit.edu	37	1	177245384	177245384	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177245384G>A	uc001glf.2	+	6	1138	c.826G>A	c.(826-828)GCA>ACA	p.A276T	FAM5B_uc010pna.1_Missense_Mutation_p.A26T|FAM5B_uc001glg.2_Missense_Mutation_p.A171T	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	276						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
FAM5B	57795	broad.mit.edu	37	1	177249772	177249772	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177249772C>G	uc001glf.2	+	8	1772	c.1460C>G	c.(1459-1461)GCC>GGC	p.A487G	FAM5B_uc001glg.2_Missense_Mutation_p.A382G	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	487						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
TDRD5	163589	broad.mit.edu	37	1	179561744	179561744	+	Translation_Start_Site	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179561744G>T	uc001gnf.1	+	2	244	c.-6G>T	c.(-8--4)TAGGG>TATGG		TDRD5_uc010pnp.1_Translation_Start_Site|uc001gne.2_5'Flank|uc010pno.1_5'Flank	NM_173533	NP_775804			tudor domain containing 5						DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181727985	181727985	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181727985T>C	uc001gow.2	+	32	4751	c.4586T>C	c.(4585-4587)GTC>GCC	p.V1529A	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1417A|CACNA1E_uc001gox.1_Missense_Mutation_p.V755A|CACNA1E_uc009wxt.2_Missense_Mutation_p.V755A	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1529	Helical; Name=S2 of repeat IV.|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
DHX9	1660	broad.mit.edu	37	1	182836115	182836115	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182836115A>G	uc001gpr.2	+	14	1657	c.1494A>G	c.(1492-1494)TTA>TTG	p.L498L	DHX9_uc001gps.2_Silent_p.L284L	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	498	Helicase ATP-binding.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2																		---	---	---	---
RGL1	23179	broad.mit.edu	37	1	183881241	183881241	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183881241A>G	uc001gqo.2	+	15	1745	c.1588A>G	c.(1588-1590)ACC>GCC	p.T530A	RGL1_uc010pof.1_Missense_Mutation_p.T335A|RGL1_uc001gqm.2_Missense_Mutation_p.T565A|RGL1_uc010pog.1_Missense_Mutation_p.T528A|RGL1_uc010poh.1_Missense_Mutation_p.T528A|RGL1_uc010poi.1_Missense_Mutation_p.T501A	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	530					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11																		---	---	---	---
RGL1	23179	broad.mit.edu	37	1	183885723	183885723	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183885723C>T	uc001gqo.2	+	16	2049	c.1892C>T	c.(1891-1893)ACG>ATG	p.T631M	RGL1_uc001gqm.2_Missense_Mutation_p.T666M|RGL1_uc010pog.1_Missense_Mutation_p.T629M|RGL1_uc010poh.1_Missense_Mutation_p.T629M|RGL1_uc010poi.1_Missense_Mutation_p.T602M	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	631					cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11																		---	---	---	---
C1orf26	54823	broad.mit.edu	37	1	185137497	185137497	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185137497A>G	uc001grg.3	+	4	305	c.191A>G	c.(190-192)TAC>TGC	p.Y64C	C1orf26_uc001grh.3_Missense_Mutation_p.Y64C	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	64											0																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	185962440	185962440	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185962440T>C	uc001grq.1	+	23	3733	c.3504T>C	c.(3502-3504)CAT>CAC	p.H1168H	HMCN1_uc001grr.1_Silent_p.H509H	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1168					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186157003	186157003	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186157003T>C	uc001grq.1	+						HMCN1_uc001grs.1_Intron	NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
PRG4	10216	broad.mit.edu	37	1	186281960	186281960	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186281960A>G	uc001gru.3	+	12	4102	c.4051A>G	c.(4051-4053)ACC>GCC	p.T1351A	PRG4_uc001grt.3_Missense_Mutation_p.T1310A|PRG4_uc009wyl.2_Missense_Mutation_p.T1258A|PRG4_uc009wym.2_Missense_Mutation_p.T1217A|PRG4_uc010poo.1_RNA|TPR_uc001grv.2_3'UTR	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1351					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186313637	186313637	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186313637A>G	uc001grv.2	-	25	3584	c.3287T>C	c.(3286-3288)CTA>CCA	p.L1096P		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1096	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
TPR	7175	broad.mit.edu	37	1	186332468	186332468	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186332468A>G	uc001grv.2	-						TPR_uc010pop.1_Intron	NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
FAM5C	339479	broad.mit.edu	37	1	190067644	190067644	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:190067644T>C	uc001gse.1	-	8	2037	c.1805A>G	c.(1804-1806)GAC>GGC	p.D602G	FAM5C_uc010pot.1_Missense_Mutation_p.D500G	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	602						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)																	---	---	---	---
RGS21	431704	broad.mit.edu	37	1	192321348	192321348	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192321348G>A	uc001gsh.2	+							NM_001039152	NP_001034241			regulator of G-protein signaling 21						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2																		---	---	---	---
RGS1	5996	broad.mit.edu	37	1	192547467	192547467	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192547467A>G	uc001gsi.1	+	4	462	c.396A>G	c.(394-396)AAA>AAG	p.K132K	RGS1_uc010pou.1_Silent_p.K132K	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	132	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)																---	---	---	---
B3GALT2	8707	broad.mit.edu	37	1	193149827	193149827	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:193149827T>C	uc001gtc.3	-	2	1581	c.866A>G	c.(865-867)AAT>AGT	p.N289S	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	289	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1																		---	---	---	---
CFHR2	3080	broad.mit.edu	37	1	196928105	196928105	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:196928105A>G	uc001gtq.1	+	5	785	c.708A>G	c.(706-708)ATA>ATG	p.I236M	CFHR2_uc001gtr.1_Missense_Mutation_p.I112M	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	236	Sushi 4.					extracellular region				skin(2)|ovary(1)	3																		---	---	---	---
F13B	2165	broad.mit.edu	37	1	197026524	197026524	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197026524G>A	uc001gtt.1	-	6	921	c.877C>T	c.(877-879)CGT>TGT	p.R293C		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	293	Sushi 5.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197091116	197091116	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197091116T>C	uc001gtu.2	-	16	4056	c.3799A>G	c.(3799-3801)ATA>GTA	p.I1267V	ASPM_uc001gtv.2_Missense_Mutation_p.I1267V|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1267					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
ASPM	259266	broad.mit.edu	37	1	197097731	197097731	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197097731C>T	uc001gtu.2	-	10	3082	c.2825G>A	c.(2824-2826)CGT>CAT	p.R942H	ASPM_uc001gtv.2_Missense_Mutation_p.R942H|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	942	CH 1.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
ZBTB41	360023	broad.mit.edu	37	1	197157461	197157461	+	Missense_Mutation	SNP	G	A	A	rs146939360	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197157461G>A	uc001gtx.1	-	4	1576	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	503	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
ZBTB41	360023	broad.mit.edu	37	1	197168674	197168674	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197168674C>T	uc001gtx.1	-	1	999	c.930G>A	c.(928-930)GAG>GAA	p.E310E	ZBTB41_uc009wyz.1_RNA|CRB1_uc010poz.1_5'Flank	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
ZBTB41	360023	broad.mit.edu	37	1	197169174	197169174	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197169174A>G	uc001gtx.1	-	1	499	c.430T>C	c.(430-432)TAC>CAC	p.Y144H	ZBTB41_uc009wyz.1_RNA|CRB1_uc010poz.1_5'Flank	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	144	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
PTPRC	5788	broad.mit.edu	37	1	198668766	198668766	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:198668766G>A	uc001gur.1	+	5	546	c.366G>A	c.(364-366)ACG>ACA	p.T122T	PTPRC_uc001gus.1_Silent_p.T122T|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Silent_p.T58T|PTPRC_uc009wzf.1_Silent_p.T58T|PTPRC_uc010ppg.1_Silent_p.T58T|PTPRC_uc001guu.1_Silent_p.T165T|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	122	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12																OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PTPRC	5788	broad.mit.edu	37	1	198668804	198668804	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:198668804A>G	uc001gur.1	+	5	584	c.404A>G	c.(403-405)AAC>AGC	p.N135S	PTPRC_uc001gus.1_Missense_Mutation_p.N135S|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.N71S|PTPRC_uc009wzf.1_Missense_Mutation_p.N71S|PTPRC_uc010ppg.1_Missense_Mutation_p.N71S|PTPRC_uc001guu.1_Missense_Mutation_p.N178S|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	135	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12																OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PTPRC	5788	broad.mit.edu	37	1	198687384	198687384	+	Missense_Mutation	SNP	G	A	A	rs144856406	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:198687384G>A	uc001gur.1	+	14	1786	c.1606G>A	c.(1606-1608)GAT>AAT	p.D536N	PTPRC_uc001gus.1_Missense_Mutation_p.D488N|PTPRC_uc001gut.1_Missense_Mutation_p.D375N|PTPRC_uc009wzf.1_Missense_Mutation_p.D424N|PTPRC_uc010ppg.1_Missense_Mutation_p.D472N	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	536	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12																		---	---	---	---
CAMSAP1L1	23271	broad.mit.edu	37	1	200818150	200818150	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200818150G>A	uc001gvl.2	+	12	2556	c.2286G>A	c.(2284-2286)GTG>GTA	p.V762V	CAMSAP1L1_uc001gvk.2_Silent_p.V751V|CAMSAP1L1_uc001gvm.2_Silent_p.V735V	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	762						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
CACNA1S	779	broad.mit.edu	37	1	201052326	201052326	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201052326G>A	uc001gvv.2	-	10	1584	c.1357C>T	c.(1357-1359)CAC>TAC	p.H453Y		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	453	Extracellular (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)													---	---	---	---
NAV1	89796	broad.mit.edu	37	1	201617978	201617978	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201617978C>T	uc001gwu.2	+	1	529	c.182C>T	c.(181-183)GCG>GTG	p.A61V		NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	61					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
NAV1	89796	broad.mit.edu	37	1	201751603	201751603	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201751603G>A	uc001gwu.2	+	6	2310	c.1963G>A	c.(1963-1965)GCA>ACA	p.A655T	NAV1_uc001gwv.1_Missense_Mutation_p.A163T|NAV1_uc001gww.1_Missense_Mutation_p.A264T|NAV1_uc001gwx.2_Missense_Mutation_p.A264T|NAV1_uc001gwy.1_Missense_Mutation_p.A36T	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	655					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
ELF3	1999	broad.mit.edu	37	1	201983146	201983146	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201983146C>T	uc001gxg.3	+	7	4187	c.995C>T	c.(994-996)GCC>GTC	p.A332V	ELF3_uc001gxi.3_Missense_Mutation_p.A332V|ELF3_uc001gxh.3_Missense_Mutation_p.A332V	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	332	ETS.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0																		---	---	---	---
PTPN7	5778	broad.mit.edu	37	1	202123315	202123315	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202123315T>G	uc001gxm.1	-	6	736	c.605A>C	c.(604-606)GAG>GCG	p.E202A	PTPN7_uc001gxl.1_Missense_Mutation_p.E241A|PTPN7_uc001gxn.1_Missense_Mutation_p.E202A|PTPN7_uc010ppv.1_Missense_Mutation_p.E21A|PTPN7_uc010ppw.1_Missense_Mutation_p.E150A|PTPN7_uc010ppx.1_Missense_Mutation_p.E276A|PTPN7_uc010ppy.1_Intron|PTPN7_uc001gxo.1_Missense_Mutation_p.E154A	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	202	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1																		---	---	---	---
KDM5B	10765	broad.mit.edu	37	1	202700079	202700079	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202700079C>T	uc001gyf.2	-	25	4250	c.4134G>A	c.(4132-4134)CAG>CAA	p.Q1378Q	KDM5B_uc009xag.2_Silent_p.Q1414Q|KDM5B_uc001gyg.1_Silent_p.Q1220Q	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1378					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5																		---	---	---	---
KDM5B	10765	broad.mit.edu	37	1	202702811	202702811	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202702811A>G	uc001gyf.2	-	23	3743	c.3627T>C	c.(3625-3627)ATT>ATC	p.I1209I	KDM5B_uc009xag.2_Silent_p.I1245I|KDM5B_uc001gyg.1_Silent_p.I1051I	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1209	PHD-type 2.				negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5																		---	---	---	---
PPFIA4	8497	broad.mit.edu	37	1	203012612	203012612	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203012612C>T	uc009xaj.2	+	7	763	c.763C>T	c.(763-765)CGG>TGG	p.R255W	PPFIA4_uc010pqf.1_5'Flank			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
PPFIA4	8497	broad.mit.edu	37	1	203024745	203024745	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203024745A>G	uc001gyz.2	+	3	1090	c.497A>G	c.(496-498)AAG>AGG	p.K166R	PPFIA4_uc009xaj.2_Missense_Mutation_p.K797R|PPFIA4_uc010pqf.1_Missense_Mutation_p.K379R|PPFIA4_uc001gza.2_Missense_Mutation_p.K166R|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	166					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5																		---	---	---	---
CHI3L1	1116	broad.mit.edu	37	1	203149784	203149784	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203149784G>T	uc001gzi.2	-						FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Intron|CHI3L1_uc001gzj.2_Intron|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267			chitinase 3-like 1 precursor						chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1																		---	---	---	---
FMOD	2331	broad.mit.edu	37	1	203317279	203317279	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203317279A>G	uc001gzr.2	-	2	256	c.120T>C	c.(118-120)GAT>GAC	p.D40D	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	40					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)															---	---	---	---
PLEKHA6	22874	broad.mit.edu	37	1	204236645	204236645	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204236645G>A	uc001hau.2	-	5	555	c.238C>T	c.(238-240)CGC>TGC	p.R80C		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	80	PH.									ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)															---	---	---	---
PIK3C2B	5287	broad.mit.edu	37	1	204418333	204418333	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204418333G>A	uc001haw.2	-	15	2805	c.2326C>T	c.(2326-2328)CCA>TCA	p.P776S	PIK3C2B_uc010pqv.1_Missense_Mutation_p.P776S	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	776					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)															---	---	---	---
NFASC	23114	broad.mit.edu	37	1	204937448	204937448	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204937448C>T	uc001hbj.2	+	9	1106	c.778C>T	c.(778-780)CGT>TGT	p.R260C	NFASC_uc001hbh.2_Missense_Mutation_p.R260C|NFASC_uc010pqz.1_Missense_Mutation_p.R254C|NFASC_uc010pra.1_Missense_Mutation_p.R271C|NFASC_uc001hbi.2_Missense_Mutation_p.R271C|NFASC_uc009xbg.1_Missense_Mutation_p.R344C|NFASC_uc010prb.1_Missense_Mutation_p.R271C|NFASC_uc010prc.1_5'UTR|NFASC_uc001hbk.1_Missense_Mutation_p.R81C	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	260	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
NFASC	23114	broad.mit.edu	37	1	204945914	204945914	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204945914A>G	uc001hbj.2	+	16	2150	c.1822A>G	c.(1822-1824)ACC>GCC	p.T608A	NFASC_uc001hbh.2_Missense_Mutation_p.T608A|NFASC_uc010pqz.1_Missense_Mutation_p.T602A|NFASC_uc010pra.1_Missense_Mutation_p.T619A|NFASC_uc001hbi.2_Missense_Mutation_p.T619A|NFASC_uc010prb.1_Missense_Mutation_p.T619A|NFASC_uc010prc.1_Missense_Mutation_p.T175A|NFASC_uc001hbk.1_Missense_Mutation_p.T429A	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	608	Extracellular (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
TMEM81	388730	broad.mit.edu	37	1	205052683	205052683	+	Nonstop_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205052683A>G	uc001hbt.2	-	1	906	c.766T>C	c.(766-768)TGA>CGA	p.*256R		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	256						integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)															---	---	---	---
RBBP5	5929	broad.mit.edu	37	1	205074295	205074295	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205074295A>G	uc001hbu.1	-	4	350	c.220T>C	c.(220-222)TGG>CGG	p.W74R	RBBP5_uc010prd.1_Missense_Mutation_p.W109R|RBBP5_uc001hbv.1_Missense_Mutation_p.W74R|RBBP5_uc010pre.1_5'UTR	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	74	WD 2.				histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)															---	---	---	---
KLHDC8A	55220	broad.mit.edu	37	1	205312636	205312636	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205312636C>T	uc001hcf.1	-	2	665	c.97G>A	c.(97-99)GTC>ATC	p.V33I	KLHDC8A_uc010prg.1_Intron|KLHDC8A_uc001hcg.1_Missense_Mutation_p.V33I	NM_018203	NP_060673	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	33	Kelch 2.									ovary(1)	1	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)															---	---	---	---
RAB7L1	8934	broad.mit.edu	37	1	205739514	205739514	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205739514A>G	uc001hdf.3	-	6	908	c.568T>C	c.(568-570)TAC>CAC	p.Y190H	RAB7L1_uc009xbp.2_Missense_Mutation_p.Y118H|RAB7L1_uc001hde.3_Missense_Mutation_p.Y190H|RAB7L1_uc010prr.1_Missense_Mutation_p.Y166H|RAB7L1_uc009xbq.2_RNA	NM_003929	NP_003920	O14966	RAB7L_HUMAN	RAB7, member RAS oncogene family-like 1 isoform	190					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)	1	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0194)															---	---	---	---
SRGAP2	23380	broad.mit.edu	37	1	206566999	206566999	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206566999A>G	uc001hdy.2	+	4	872	c.539A>G	c.(538-540)TAC>TGC	p.Y180C	SRGAP2_uc009xbt.2_Missense_Mutation_p.Y104C|SRGAP2_uc010prt.1_Missense_Mutation_p.Y104C|SRGAP2_uc001hdx.2_Missense_Mutation_p.Y180C|SRGAP2_uc010pru.1_Missense_Mutation_p.Y104C|SRGAP2_uc010prv.1_Missense_Mutation_p.Y104C	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	267					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)																	---	---	---	---
CR2	1380	broad.mit.edu	37	1	207639972	207639972	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207639972A>G	uc001hfw.2	+	2	254	c.160A>G	c.(160-162)ACC>GCC	p.T54A	CR2_uc001hfv.2_Missense_Mutation_p.T54A|CR2_uc009xch.2_Missense_Mutation_p.T54A	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	54	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8																		---	---	---	---
CR1	1378	broad.mit.edu	37	1	207679344	207679344	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207679344T>C	uc001hfy.2	+	2	357	c.217T>C	c.(217-219)TGC>CGC	p.C73R	CR1_uc009xcl.1_Missense_Mutation_p.C73R|CR1_uc001hfx.2_Missense_Mutation_p.C73R|CR1_uc010psg.1_Missense_Mutation_p.C73R|CR1_uc009xcj.1_Missense_Mutation_p.C73R|CR1_uc009xck.1_Missense_Mutation_p.C73R	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	73	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3																		---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207867785	207867785	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207867785C>T	uc001hga.3	+	5	672	c.551C>T	c.(550-552)ACC>ATC	p.T184I	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	184	Sushi 3.					cytoplasm|extracellular region|membrane					0																		---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207867788	207867788	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207867788A>G	uc001hga.3	+	5	675	c.554A>G	c.(553-555)TAC>TGC	p.Y185C	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	185	Sushi 3.					cytoplasm|extracellular region|membrane					0																		---	---	---	---
CD46	4179	broad.mit.edu	37	1	207940424	207940424	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207940424A>G	uc001hgc.2	+	6	896	c.740A>G	c.(739-741)TAC>TGC	p.Y247C	CD46_uc001hgd.2_Missense_Mutation_p.Y247C|CD46_uc001hge.2_Missense_Mutation_p.Y247C|CD46_uc001hgf.2_Missense_Mutation_p.Y247C|CD46_uc001hgg.2_Missense_Mutation_p.Y247C|CD46_uc001hgh.2_Missense_Mutation_p.Y247C|CD46_uc001hgi.2_Missense_Mutation_p.Y247C|CD46_uc001hgj.2_Missense_Mutation_p.Y247C|CD46_uc001hgk.2_Missense_Mutation_p.Y247C|CD46_uc001hgl.2_Missense_Mutation_p.Y247C|CD46_uc001hgm.2_Missense_Mutation_p.Y247C|CD46_uc001hgn.2_Missense_Mutation_p.Y247C|CD46_uc001hgo.2_Missense_Mutation_p.Y247C|CD46_uc001hgp.2_Missense_Mutation_p.Y247C	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	247	Extracellular (Potential).|Sushi 4.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4																		---	---	---	---
PLXNA2	5362	broad.mit.edu	37	1	208206749	208206749	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:208206749T>C	uc001hgz.2	-	28	5728	c.4970A>G	c.(4969-4971)AAC>AGC	p.N1657S		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	1657	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)														---	---	---	---
PLXNA2	5362	broad.mit.edu	37	1	208216395	208216395	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:208216395G>A	uc001hgz.2	-							NM_025179	NP_079455			plexin A2 precursor						axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)														---	---	---	---
LAMB3	3914	broad.mit.edu	37	1	209803132	209803132	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209803132T>A	uc001hhg.2	-	9	1472	c.1082A>T	c.(1081-1083)CAC>CTC	p.H361L	LAMB3_uc009xco.2_Missense_Mutation_p.H361L|LAMB3_uc001hhh.2_Missense_Mutation_p.H361L|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	361	Laminin EGF-like 2.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)														---	---	---	---
IRF6	3664	broad.mit.edu	37	1	209964008	209964008	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209964008T>C	uc001hhq.1	-	7	1155	c.892A>G	c.(892-894)ATG>GTG	p.M298V	IRF6_uc010psm.1_Missense_Mutation_p.M203V|IRF6_uc009xct.1_Missense_Mutation_p.M298V	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	298					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)											HNSCC(57;0.16)			---	---	---	---
IRF6	3664	broad.mit.edu	37	1	209964012	209964012	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209964012G>A	uc001hhq.1	-	7	1151	c.888C>T	c.(886-888)GAC>GAT	p.D296D	IRF6_uc010psm.1_Silent_p.D201D|IRF6_uc009xct.1_Silent_p.D296D	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	296			FTSKLLD -> L (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)											HNSCC(57;0.16)			---	---	---	---
IRF6	3664	broad.mit.edu	37	1	209964020	209964020	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:209964020G>A	uc001hhq.1	-	7	1143	c.880C>T	c.(880-882)CTG>TTG	p.L294L	IRF6_uc010psm.1_Silent_p.L199L|IRF6_uc009xct.1_Silent_p.L294L	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	294			FTSKLLD -> L (in VWS).|L -> P (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)											HNSCC(57;0.16)			---	---	---	---
INTS7	25896	broad.mit.edu	37	1	212142038	212142038	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212142038T>C	uc001hiw.1	-	14	1932	c.1827A>G	c.(1825-1827)ACA>ACG	p.T609T	INTS7_uc009xdb.1_Silent_p.T609T|INTS7_uc001hix.1_Silent_p.T485T|INTS7_uc001hiy.1_Silent_p.T609T|INTS7_uc010pta.1_Silent_p.T560T	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	609					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)														---	---	---	---
INTS7	25896	broad.mit.edu	37	1	212161324	212161324	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212161324G>A	uc001hiw.1	-	8	1006	c.901C>T	c.(901-903)CAG>TAG	p.Q301*	INTS7_uc009xdb.1_Nonsense_Mutation_p.Q301*|INTS7_uc001hix.1_Nonsense_Mutation_p.Q177*|INTS7_uc001hiy.1_Nonsense_Mutation_p.Q301*|INTS7_uc010pta.1_Nonsense_Mutation_p.Q252*	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	301					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)														---	---	---	---
KCNK2	3776	broad.mit.edu	37	1	215345490	215345490	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215345490A>G	uc001hkq.2	+	5	956	c.787A>G	c.(787-789)ACT>GCT	p.T263A	KCNK2_uc001hko.2_Missense_Mutation_p.T259A|KCNK2_uc009xdm.2_Intron|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.T248A	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	263							outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)													---	---	---	---
USH2A	7399	broad.mit.edu	37	1	215802205	215802205	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215802205A>G	uc001hku.1	-	71	15857	c.15470T>C	c.(15469-15471)TTG>TCG	p.L5157S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	5157	Cytoplasmic (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
USH2A	7399	broad.mit.edu	37	1	215953368	215953368	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215953368T>C	uc001hku.1	-	55	11143	c.10756A>G	c.(10756-10758)ACC>GCC	p.T3586A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3586	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216405425	216405425	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216405425T>C	uc001hku.1	-	14	3250	c.2863A>G	c.(2863-2865)ACA>GCA	p.T955A	USH2A_uc001hkv.2_Missense_Mutation_p.T955A	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	955	Extracellular (Potential).|Laminin EGF-like 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216497021	216497021	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216497021G>A	uc001hku.1	-	8	1732	c.1345C>T	c.(1345-1347)CGT>TGT	p.R449C	USH2A_uc001hkv.2_Missense_Mutation_p.R449C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	449	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
ESRRG	2104	broad.mit.edu	37	1	216850574	216850574	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216850574T>C	uc001hkw.1	-	2	482	c.316A>G	c.(316-318)AGC>GGC	p.S106G	ESRRG_uc001hky.1_Missense_Mutation_p.S83G|ESRRG_uc009xdp.1_Missense_Mutation_p.S83G|ESRRG_uc001hkz.1_Missense_Mutation_p.S83G|ESRRG_uc010puc.1_Missense_Mutation_p.S83G|ESRRG_uc001hla.1_Missense_Mutation_p.S83G|ESRRG_uc001hlb.1_Missense_Mutation_p.S83G|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Missense_Mutation_p.S83G|ESRRG_uc001hld.1_Missense_Mutation_p.S83G|ESRRG_uc001hkx.1_Missense_Mutation_p.S111G|ESRRG_uc009xdo.1_Missense_Mutation_p.S83G|ESRRG_uc001hle.1_Missense_Mutation_p.S83G	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	106					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)													---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217783709	217783709	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217783709A>G	uc001hlf.1	-	5	1148	c.1052T>C	c.(1051-1053)ATG>ACG	p.M351T	GPATCH2_uc001hlg.3_Missense_Mutation_p.M351T	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	351						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
TGFB2	7042	broad.mit.edu	37	1	218614599	218614599	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:218614599C>T	uc001hlm.2	+	7	1793	c.1140C>T	c.(1138-1140)TGC>TGT	p.C380C	TGFB2_uc001hln.2_Silent_p.C408C|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	380					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)														---	---	---	---
EPRS	2058	broad.mit.edu	37	1	220170682	220170682	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220170682G>T	uc001hly.1	-	18	2454	c.2184C>A	c.(2182-2184)ACC>ACA	p.T728T	EPRS_uc010puf.1_Silent_p.T479T|EPRS_uc001hlz.1_Silent_p.T735T	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	728	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)													---	---	---	---
MARK1	4139	broad.mit.edu	37	1	220826557	220826557	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220826557A>G	uc001hmn.3	+	16	2448	c.1851A>G	c.(1849-1851)GAA>GAG	p.E617E	MARK1_uc009xdw.2_Silent_p.E618E|MARK1_uc010pun.1_Silent_p.E617E|MARK1_uc001hmm.3_Silent_p.E595E	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	617					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)														---	---	---	---
TLR5	7100	broad.mit.edu	37	1	223285544	223285544	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223285544G>T	uc001hnv.1	-	4	1276	c.830C>A	c.(829-831)CCT>CAT	p.P277H	TLR5_uc001hnw.1_Missense_Mutation_p.P277H	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	277	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)														---	---	---	---
C1orf65	164127	broad.mit.edu	37	1	223567614	223567614	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223567614G>A	uc001hoa.2	+	1	900	c.797G>A	c.(796-798)CGT>CAT	p.R266H		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	266	Potential.									central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)														---	---	---	---
CNIH3	149111	broad.mit.edu	37	1	224804920	224804920	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224804920T>C	uc001hos.1	+	1	742	c.44T>C	c.(43-45)GTG>GCG	p.V15A		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	15	Helical; (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)														---	---	---	---
CNIH3	149111	broad.mit.edu	37	1	224868721	224868721	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224868721T>C	uc001hos.1	+	2	841	c.143T>C	c.(142-144)GTT>GCT	p.V48A		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	48	Lumenal (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)														---	---	---	---
CNIH3	149111	broad.mit.edu	37	1	224922301	224922301	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224922301C>A	uc001hos.1	+	5	1046	c.348C>A	c.(346-348)GCC>GCA	p.A116A		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	116	Cytoplasmic (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)														---	---	---	---
DNAH14	127602	broad.mit.edu	37	1	225142738	225142738	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:225142738A>T	uc001how.2	+	3	370	c.155A>T	c.(154-156)GAA>GTA	p.E52V	DNAH14_uc001hou.3_Missense_Mutation_p.E52V|DNAH14_uc001hot.3_Missense_Mutation_p.E52V|DNAH14_uc001hov.3_Missense_Mutation_p.E52V	NM_001373	NP_001364	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy polypeptide 14 isoform	229					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1																		---	---	---	---
LIN9	286826	broad.mit.edu	37	1	226483533	226483533	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226483533A>G	uc001hqa.2	-						LIN9_uc001hqb.2_Intron|LIN9_uc001hqc.2_Intron|LIN9_uc009xel.1_Intron	NM_173083	NP_775106			lin-9 homolog						cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)														---	---	---	---
PARP1	142	broad.mit.edu	37	1	226552822	226552822	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:226552822G>A	uc001hqd.3	-	19	2710	c.2539C>T	c.(2539-2541)CGT>TGT	p.R847C		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	847	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
CDC42BPA	8476	broad.mit.edu	37	1	227216861	227216861	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227216861C>T	uc001hqr.2	-	29	4767	c.3824G>A	c.(3823-3825)CGT>CAT	p.R1275H	CDC42BPA_uc001hqq.2_Missense_Mutation_p.R574H|CDC42BPA_uc001hqs.2_Missense_Mutation_p.R1194H|CDC42BPA_uc009xes.2_Missense_Mutation_p.R1247H|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R1255H|CDC42BPA_uc001hqp.2_Missense_Mutation_p.R431H|CDC42BPA_uc001hqt.2_Missense_Mutation_p.R153H|CDC42BPA_uc001hqu.1_Missense_Mutation_p.R482H	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	1288	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)																---	---	---	---
CDC42BPA	8476	broad.mit.edu	37	1	227335223	227335223	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227335223A>T	uc001hqr.2	-	7	1674	c.731T>A	c.(730-732)ATC>AAC	p.I244N	CDC42BPA_uc001hqs.2_Missense_Mutation_p.I244N|CDC42BPA_uc009xes.2_Missense_Mutation_p.I244N|CDC42BPA_uc010pvs.1_Missense_Mutation_p.I244N	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	244	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)																---	---	---	---
ZNF678	339500	broad.mit.edu	37	1	227842264	227842264	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227842264A>G	uc001hqw.1	+	4	658	c.313A>G	c.(313-315)AAT>GAT	p.N105D	ZNF678_uc009xet.1_Intron|ZNF678_uc009xeu.1_Intron	NM_178549	NP_848644	F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	160					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			pancreas(1)	1		Prostate(94;0.0885)																---	---	---	---
JMJD4	65094	broad.mit.edu	37	1	227921375	227921375	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:227921375A>G	uc001hrb.2	-	4	700	c.700T>C	c.(700-702)TTC>CTC	p.F234L	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Missense_Mutation_p.F234L	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	234	JmjC.										0		Prostate(94;0.0885)																---	---	---	---
WNT3A	89780	broad.mit.edu	37	1	228238516	228238516	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228238516A>G	uc001hrq.1	+	3	551	c.473A>G	c.(472-474)GAC>GGC	p.D158G	WNT3A_uc001hrp.1_Missense_Mutation_p.D158G	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	158					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)																---	---	---	---
GUK1	2987	broad.mit.edu	37	1	228333221	228333221	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228333221G>C	uc001hsh.2	+	3	311	c.8G>C	c.(7-9)GGC>GCC	p.G3A	GUK1_uc001hsi.2_Missense_Mutation_p.G24A|GUK1_uc001hsj.2_5'UTR|GUK1_uc010pvv.1_Missense_Mutation_p.G3A	NM_000858	NP_000849	Q16774	KGUA_HUMAN	guanylate kinase 1 isoform b	3					nucleobase, nucleoside and nucleotide interconversion|purine nucleotide metabolic process	cytosol	ATP binding|guanylate kinase activity				0		Prostate(94;0.0405)																---	---	---	---
GJC2	57165	broad.mit.edu	37	1	228346175	228346175	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228346175T>C	uc001hsk.2	+	2	891	c.716T>C	c.(715-717)GTG>GCG	p.V239A		NM_020435	NP_065168	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	239	Extracellular (Potential).				cell death	connexon complex|integral to membrane					0		Prostate(94;0.0405)																---	---	---	---
C1orf69	200205	broad.mit.edu	37	1	228363092	228363092	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228363092G>A	uc001hsl.3	+	3	1038	c.949G>A	c.(949-951)GTG>ATG	p.V317M	C1orf69_uc010pvw.1_Missense_Mutation_p.V124M	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	317					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228433238	228433238	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228433238C>T	uc009xez.1	+	12	3650	c.3606C>T	c.(3604-3606)GAC>GAT	p.D1202D	OBSCN_uc001hsn.2_Silent_p.D1202D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1202	Ig-like 12.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228456347	228456347	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228456347T>C	uc009xez.1	+	17	5022	c.4978T>C	c.(4978-4980)TAC>CAC	p.Y1660H	OBSCN_uc001hsn.2_Missense_Mutation_p.Y1660H|OBSCN_uc001hso.2_Missense_Mutation_p.Y106H	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1660	Ig-like 17.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228509588	228509588	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228509588C>T	uc009xez.1	+	55	15090	c.15046C>T	c.(15046-15048)CGG>TGG	p.R5016W	OBSCN_uc001hsn.2_Missense_Mutation_p.R5016W	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5016					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
ACTA1	58	broad.mit.edu	37	1	229568012	229568012	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229568012C>T	uc001htm.2	-							NM_001100	NP_001091			actin, alpha 1, skeletal muscle						muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)													---	---	---	---
TTC13	79573	broad.mit.edu	37	1	231064815	231064815	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231064815T>C	uc001huf.3	-	12	1356	c.1325A>G	c.(1324-1326)CAC>CGC	p.H442R	TTC13_uc009xfi.2_Missense_Mutation_p.H389R|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.H389R|TTC13_uc009xfk.1_Missense_Mutation_p.H332R	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	442							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)														---	---	---	---
C1orf124	83932	broad.mit.edu	37	1	231487299	231487299	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231487299T>G	uc001hur.2	+	4	1148	c.700T>G	c.(700-702)TTG>GTG	p.L234V	C1orf124_uc001hus.2_Missense_Mutation_p.L234V|C1orf124_uc001hut.2_Missense_Mutation_p.L191V	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	234					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)																---	---	---	---
TSNAX	7257	broad.mit.edu	37	1	231673007	231673007	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231673007T>C	uc001huw.2	+	3	328	c.170T>C	c.(169-171)GTG>GCG	p.V57A	TSNAX-DISC1_uc010pwe.1_5'UTR|TSNAX-DISC1_uc010pwf.1_5'UTR|TSNAX-DISC1_uc010pwg.1_5'UTR|TSNAX-DISC1_uc010pwh.1_5'UTR|TSNAX-DISC1_uc010pwi.1_Intron|TSNAX-DISC1_uc010pwj.1_5'UTR|TSNAX-DISC1_uc010pwk.1_5'UTR|TSNAX-DISC1_uc010pwl.1_RNA	NM_005999	NP_005990	Q99598	TSNAX_HUMAN	translin-associated factor X	57					cell differentiation|multicellular organismal development|spermatogenesis	nucleus|perinuclear region of cytoplasm	protein transporter activity|sequence-specific DNA binding				0		all_cancers(173;0.0395)|Acute lymphoblastic leukemia(190;3.76e-06)|Prostate(94;0.116)																---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232538136	232538136	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232538136A>G	uc001hvg.2	-	20	5180	c.5022_splice	c.e20+1	p.K1674_splice	SIPA1L2_uc001hvf.2_Splice_Site_p.K730_splice	NM_020808	NP_065859			signal-induced proliferation-associated 1 like						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
SIPA1L2	57568	broad.mit.edu	37	1	232650649	232650649	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232650649A>G	uc001hvg.2	-	1	595	c.437T>C	c.(436-438)GTC>GCC	p.V146A		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	146					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)																---	---	---	---
PCNXL2	80003	broad.mit.edu	37	1	233394715	233394715	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233394715C>T	uc001hvl.2	-	5	1128	c.893G>A	c.(892-894)CGG>CAG	p.R298Q	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	298						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)																---	---	---	---
KCNK1	3775	broad.mit.edu	37	1	233785789	233785789	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233785789A>G	uc010pxo.1	+						KCNK1_uc001hvw.2_Intron|KCNK1_uc001hvx.2_Intron	NM_002245	NP_002236			potassium channel, subfamily K, member 1							voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)													---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234556438	234556438	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234556438A>G	uc001hwd.2	-							NM_005646	NP_005637			TAR RNA binding protein 1						regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234563331	234563331	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234563331C>T	uc001hwd.2	-	18	3242	c.3242G>A	c.(3241-3243)CGT>CAT	p.R1081H		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1081					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
TARBP1	6894	broad.mit.edu	37	1	234565023	234565023	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:234565023C>T	uc001hwd.2	-	17	2919	c.2919G>A	c.(2917-2919)GCG>GCA	p.A973A		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	973					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)															---	---	---	---
RBM34	23029	broad.mit.edu	37	1	235324296	235324296	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235324296T>C	uc001hwn.2	-	2	170	c.140A>G	c.(139-141)CAC>CGC	p.H47R	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.H47R	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	47						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)															---	---	---	---
B3GALNT2	148789	broad.mit.edu	37	1	235658060	235658060	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235658060T>C	uc001hxc.2	-	2	420	c.191A>G	c.(190-192)CAT>CGT	p.H64R	B3GALNT2_uc001hxd.1_Missense_Mutation_p.H105R	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	64	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)															---	---	---	---
LYST	1130	broad.mit.edu	37	1	235827885	235827885	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235827885T>C	uc001hxj.2	-	51	11250	c.11075A>G	c.(11074-11076)AAC>AGC	p.N3692S	LYST_uc001hxi.2_Missense_Mutation_p.N916S	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3692	WD 5.				defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
LYST	1130	broad.mit.edu	37	1	235922883	235922883	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235922883A>G	uc001hxj.2	-	23	6445	c.6270T>C	c.(6268-6270)AAT>AAC	p.N2090N	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2090					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
NID1	4811	broad.mit.edu	37	1	236148697	236148697	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236148697T>C	uc001hxo.2	-	15	3139	c.3037A>G	c.(3037-3039)ACC>GCC	p.T1013A	NID1_uc009xgd.2_Missense_Mutation_p.T880A|NID1_uc009xgc.2_Missense_Mutation_p.T99A	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1013	LDL-receptor class B 1.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)													---	---	---	---
ACTN2	88	broad.mit.edu	37	1	236914881	236914881	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236914881A>G	uc001hyf.2	+	15	1972	c.1768A>G	c.(1768-1770)AAC>GAC	p.N590D	ACTN2_uc001hyg.2_Missense_Mutation_p.N382D|ACTN2_uc009xgi.1_Missense_Mutation_p.N590D|ACTN2_uc010pxu.1_Missense_Mutation_p.N279D|ACTN2_uc001hyh.2_Missense_Mutation_p.N278D	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	590	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)															---	---	---	---
MTR	4548	broad.mit.edu	37	1	236995292	236995292	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236995292T>C	uc001hyi.3	+	13	1525	c.1102T>C	c.(1102-1104)TAC>CAC	p.Y368H	MTR_uc010pxw.1_Intron|MTR_uc010pxx.1_Missense_Mutation_p.Y368H|MTR_uc010pxy.1_Missense_Mutation_p.Y368H	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	368					nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)													---	---	---	---
MTR	4548	broad.mit.edu	37	1	237016301	237016301	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237016301T>C	uc001hyi.3	+	18	2289	c.1866T>C	c.(1864-1866)GAT>GAC	p.D622D	MTR_uc010pxw.1_Silent_p.D215D|MTR_uc010pxx.1_Silent_p.D622D|MTR_uc010pxy.1_Intron	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	622	Pterin-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)													---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237838135	237838135	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237838135T>A	uc001hyl.1	+	60	8939	c.8819T>A	c.(8818-8820)ATC>AAC	p.I2940N	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2940	Modulator (Potential).|Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
CHRM3	1131	broad.mit.edu	37	1	240071898	240071898	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240071898T>C	uc001hyp.2	+	5	1926	c.1147T>C	c.(1147-1149)TTA>CTA	p.L383L		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	383	Cytoplasmic (By similarity).			KLP -> RLS (in Ref. 7; AAG30036).	cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)													---	---	---	---
FMN2	56776	broad.mit.edu	37	1	240286491	240286491	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240286491T>C	uc010pyd.1	+	2	1853	c.1628T>C	c.(1627-1629)TTG>TCG	p.L543S	FMN2_uc010pye.1_Missense_Mutation_p.L543S	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	543					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)															---	---	---	---
RGS7	6000	broad.mit.edu	37	1	240966228	240966228	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240966228C>T	uc001hyv.2	-	16	1665	c.1335G>A	c.(1333-1335)CAG>CAA	p.Q445Q	RGS7_uc010pyh.1_Silent_p.Q419Q|RGS7_uc010pyj.1_Silent_p.Q361Q|RGS7_uc001hyu.2_Silent_p.Q445Q|RGS7_uc009xgn.1_Silent_p.Q392Q|RGS7_uc001hyw.2_Silent_p.Q445Q|RGS7_uc001hyt.2_Silent_p.Q277Q	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	445	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)															---	---	---	---
ZNF238	10472	broad.mit.edu	37	1	244218042	244218042	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244218042T>A	uc001iae.2	+	1	1461	c.939T>A	c.(937-939)CAT>CAA	p.H313Q	ZNF238_uc001iad.3_Missense_Mutation_p.H322Q|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	313	Interaction with DNMT3A.				negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)															---	---	---	---
AHCTF1	25909	broad.mit.edu	37	1	247013668	247013668	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247013668T>C	uc001ibu.1	-	32	5647	c.5640A>G	c.(5638-5640)GAA>GAG	p.E1880E	AHCTF1_uc001ibv.1_Silent_p.E1889E|AHCTF1_uc009xgs.1_Silent_p.E741E|AHCTF1_uc001ibw.1_RNA	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	1880	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
AHCTF1	25909	broad.mit.edu	37	1	247051505	247051505	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247051505C>T	uc001ibu.1	-	18	2306	c.2299G>A	c.(2299-2301)GTT>ATT	p.V767I	AHCTF1_uc001ibv.1_Missense_Mutation_p.V776I|AHCTF1_uc009xgs.1_5'UTR	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	767	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
ZNF695	57116	broad.mit.edu	37	1	247150946	247150946	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247150946T>C	uc009xgu.2	-	4	1016	c.871A>G	c.(871-873)ACT>GCT	p.T291A	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	291					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)															---	---	---	---
VN1R5	317705	broad.mit.edu	37	1	247420160	247420160	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247420160C>T	uc010pyu.1	+	2	787	c.787C>T	c.(787-789)CCA>TCA	p.P263S		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	263	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)															---	---	---	---
OR11L1	391189	broad.mit.edu	37	1	248005113	248005113	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248005113A>G	uc001idn.1	-	1	86	c.86T>C	c.(85-87)GTC>GCC	p.V29A		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)															---	---	---	---
OR2L8	391190	broad.mit.edu	37	1	248112616	248112616	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248112616A>C	uc001idt.1	+	1	457	c.457A>C	c.(457-459)ATC>CTC	p.I153L	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)															---	---	---	---
OR2L2	26246	broad.mit.edu	37	1	248201952	248201952	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248201952C>A	uc001idw.2	+	1	479	c.383C>A	c.(382-384)CCT>CAT	p.P128H	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)															---	---	---	---
OR2L13	284521	broad.mit.edu	37	1	248263216	248263216	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248263216T>A	uc001ids.2	+	3	876	c.539T>A	c.(538-540)GTC>GAC	p.V180D		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)															---	---	---	---
OR2T2	401992	broad.mit.edu	37	1	248616758	248616758	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248616758G>A	uc001iek.1	+	1	660	c.660G>A	c.(658-660)ACG>ACA	p.T220T		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	220	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---
OR2G6	391211	broad.mit.edu	37	1	248685072	248685072	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248685072A>G	uc001ien.1	+	1	125	c.125A>G	c.(124-126)AAC>AGC	p.N42S		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---
OR2T10	127069	broad.mit.edu	37	1	248756250	248756250	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:248756250A>G	uc010pzn.1	-	1	820	c.820T>C	c.(820-822)TCA>CCA	p.S274P		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)															---	---	---	---
ACP1	52	broad.mit.edu	37	2	271876	271876	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:271876T>C	uc002qwg.2	+	2	150	c.54T>C	c.(52-54)TGT>TGC	p.C18C	ACP1_uc002qwd.2_Silent_p.C18C|ACP1_uc002qwe.3_RNA|ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Silent_p.C18C	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	18				CLGNICRS -> PARREAAR (in Ref. 5; AAB27085).		cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)														---	---	---	---
SNTG2	54221	broad.mit.edu	37	2	1271265	1271265	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1271265C>T	uc002qwq.2	+	14	1334	c.1206C>T	c.(1204-1206)AAC>AAT	p.N402N	SNTG2_uc010ewi.2_Silent_p.N275N	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	402	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)														---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1652950	1652950	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1652950G>A	uc002qxa.2	-	17	2666	c.2602C>T	c.(2602-2604)CGG>TGG	p.R868W		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	868					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
MYT1L	23040	broad.mit.edu	37	2	1983521	1983521	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1983521T>C	uc002qxe.2	-	6	856	c.29A>G	c.(28-30)CAT>CGT	p.H10R	MYT1L_uc002qxd.2_Missense_Mutation_p.H10R|MYT1L_uc002qxf.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	10					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)														---	---	---	---
RNF144A	9781	broad.mit.edu	37	2	7170296	7170296	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:7170296C>T	uc002qys.2	+	8	1139	c.697C>T	c.(697-699)CGG>TGG	p.R233W	RNF144A_uc002qyt.2_Missense_Mutation_p.R82W	NM_014746	NP_055561	P50876	R144A_HUMAN	ring finger protein 144	233						Golgi apparatus|integral to membrane	ligase activity|zinc ion binding			ovary(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;0.226)		OV - Ovarian serous cystadenocarcinoma(76;0.195)														---	---	---	---
KIDINS220	57498	broad.mit.edu	37	2	8871241	8871241	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8871241C>T	uc002qzc.2	-	30	5107	c.4925G>A	c.(4924-4926)CGG>CAG	p.R1642Q	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.R1543Q|KIDINS220_uc002qzb.2_Missense_Mutation_p.R496Q	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1642	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
KIDINS220	57498	broad.mit.edu	37	2	8871508	8871508	+	Missense_Mutation	SNP	G	A	A	rs76169344	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8871508G>A	uc002qzc.2	-	30	4840	c.4658C>T	c.(4657-4659)CCG>CTG	p.P1553L	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.P1454L|KIDINS220_uc002qzb.2_Missense_Mutation_p.P407L	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1553	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
KIDINS220	57498	broad.mit.edu	37	2	8952519	8952519	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8952519A>G	uc002qzc.2	-						KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Intron|KIDINS220_uc010yiw.1_Intron	NM_020738	NP_065789			kinase D-interacting substrate of 220 kDa						activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
KIDINS220	57498	broad.mit.edu	37	2	8967216	8967216	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:8967216A>G	uc002qzc.2	-	2	190	c.8T>C	c.(7-9)GTT>GCT	p.V3A	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_5'UTR|KIDINS220_uc010yiw.1_Missense_Mutation_p.V3A	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	3	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
ADAM17	6868	broad.mit.edu	37	2	9630364	9630364	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9630364G>A	uc002qzu.2	-	19	2600	c.2417C>T	c.(2416-2418)GCT>GTT	p.A806V	IAH1_uc010yiz.1_Intron|ADAM17_uc010ewy.2_Missense_Mutation_p.A789V|ADAM17_uc010ewz.2_Missense_Mutation_p.A149V	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	806	Cytoplasmic (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)														---	---	---	---
YWHAQ	10971	broad.mit.edu	37	2	9727550	9727550	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9727550T>C	uc002qzw.2	-	4	835	c.671A>G	c.(670-672)AAC>AGC	p.N224S	YWHAQ_uc002qzx.2_Missense_Mutation_p.N224S	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	224					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)														---	---	---	---
RRM2	6241	broad.mit.edu	37	2	10269216	10269216	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10269216A>G	uc002rah.2	+	9	1143	c.952A>G	c.(952-954)ACT>GCT	p.T318A		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	318					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)														---	---	---	---
NOL10	79954	broad.mit.edu	37	2	10822127	10822127	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10822127A>G	uc002raq.2	-	3	306	c.181T>C	c.(181-183)TCA>CCA	p.S61P	NOL10_uc010yje.1_Missense_Mutation_p.S61P|NOL10_uc010yjf.1_Missense_Mutation_p.S11P|NOL10_uc002rap.2_Missense_Mutation_p.S61P|NOL10_uc002rar.2_5'UTR	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	61	WD 1.					nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)														---	---	---	---
PQLC3	130814	broad.mit.edu	37	2	11312126	11312126	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11312126A>G	uc002rbc.2	+	5	563	c.430A>G	c.(430-432)ACT>GCT	p.T144A	PQLC3_uc010yjk.1_Missense_Mutation_p.T144A	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	144						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)														---	---	---	---
GREB1	9687	broad.mit.edu	37	2	11767077	11767077	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11767077A>G	uc002rbk.1	+						GREB1_uc002rbp.1_Intron	NM_014668	NP_055483			growth regulation by estrogen in breast cancer 1							integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)														---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15358989	15358989	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15358989C>T	uc002rcc.1	-	48	6366	c.6340G>A	c.(6340-6342)GGG>AGG	p.G2114R	NBAS_uc002rcb.1_Intron|NBAS_uc010exl.1_Missense_Mutation_p.G1186R|NBAS_uc002rcd.1_Intron	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2114										ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
SMC6	79677	broad.mit.edu	37	2	17896257	17896257	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:17896257T>C	uc002rco.2	-	16	1897	c.1601A>G	c.(1600-1602)TAT>TGT	p.Y534C	SMC6_uc010exo.2_Missense_Mutation_p.Y534C|SMC6_uc002rcn.2_Missense_Mutation_p.Y534C|SMC6_uc002rcp.1_Missense_Mutation_p.Y560C|SMC6_uc002rcq.2_Missense_Mutation_p.Y560C	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	534	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)																	---	---	---	---
APOB	338	broad.mit.edu	37	2	21242613	21242613	+	Missense_Mutation	SNP	G	A	A	rs41288783	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:21242613G>A	uc002red.2	-	19	3109	c.2981C>T	c.(2980-2982)CCG>CTG	p.P994L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	994					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)													---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24480829	24480829	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24480829A>G	uc002rfe.2	-	23	3074	c.2816T>C	c.(2815-2817)GTG>GCG	p.V939A	ITSN2_uc002rff.2_Missense_Mutation_p.V912A|ITSN2_uc002rfg.2_Missense_Mutation_p.V939A|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	939	SH3 2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24480952	24480952	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24480952A>G	uc002rfe.2	-	23	2951	c.2693T>C	c.(2692-2694)GTA>GCA	p.V898A	ITSN2_uc002rff.2_Missense_Mutation_p.V871A|ITSN2_uc002rfg.2_Missense_Mutation_p.V898A|ITSN2_uc002rfh.1_RNA	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	898	SH3 2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
NCOA1	8648	broad.mit.edu	37	2	24888673	24888673	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24888673T>A	uc002rfk.2	+	4	403	c.145T>A	c.(145-147)TTA>ATA	p.L49I	NCOA1_uc010eye.2_Missense_Mutation_p.L49I|NCOA1_uc002rfi.2_Intron|NCOA1_uc002rfj.2_Missense_Mutation_p.L49I|NCOA1_uc002rfl.2_Missense_Mutation_p.L49I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	49	Helix-loop-helix motif.|LXXLL motif 1.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							T	PAX3	alveolar rhadomyosarcoma								---	---	---	---
NCOA1	8648	broad.mit.edu	37	2	24928022	24928022	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24928022C>T	uc002rfk.2	+	10	1275	c.1017C>T	c.(1015-1017)AGC>AGT	p.S339S	NCOA1_uc010eye.2_Silent_p.S339S|NCOA1_uc002rfi.2_Silent_p.S188S|NCOA1_uc002rfj.2_Silent_p.S339S|NCOA1_uc002rfl.2_Silent_p.S339S	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	339									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							T	PAX3	alveolar rhadomyosarcoma								---	---	---	---
CENPO	79172	broad.mit.edu	37	2	25039542	25039542	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25039542C>T	uc002rfo.1	+	6	811	c.622C>T	c.(622-624)CCC>TCC	p.P208S	CENPO_uc002rfp.1_Missense_Mutation_p.P202S|CENPO_uc002rfq.1_Missense_Mutation_p.P208S	NM_024322	NP_077298	Q9BU64	CENPO_HUMAN	centromere protein O	208					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)																	---	---	---	---
POMC	5443	broad.mit.edu	37	2	25387620	25387620	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25387620G>A	uc002rfy.1	-	3	285	c.22C>T	c.(22-24)CGC>TGC	p.R8C	POMC_uc002rfz.1_Missense_Mutation_p.R8C|POMC_uc002rga.1_Missense_Mutation_p.R8C	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	8					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)													---	---	---	---
DNMT3A	1788	broad.mit.edu	37	2	25468893	25468893	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25468893A>G	uc002rgc.2	-	12	1727	c.1470T>C	c.(1468-1470)ATT>ATC	p.I490I	DNMT3A_uc002rgd.2_Silent_p.I490I|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.I301I	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	490	ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							Mis|F|N|S		AML								---	---	---	---
C2orf18	54978	broad.mit.edu	37	2	27000990	27000990	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27000990C>T	uc002rhp.1	+	6	803	c.727C>T	c.(727-729)CGT>TGT	p.R243C	C2orf18_uc002rhq.1_Missense_Mutation_p.R160C|C2orf18_uc010eyo.1_Missense_Mutation_p.R190C|C2orf18_uc010ylc.1_Missense_Mutation_p.R96C	NM_017877	NP_060347	Q8N357	CB018_HUMAN	ANT2-binding protein precursor	243						integral to membrane|lysosomal membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
TMEM214	54867	broad.mit.edu	37	2	27262941	27262941	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27262941A>G	uc002ria.3	+	15	1776	c.1666A>G	c.(1666-1668)ACC>GCC	p.T556A	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.T511A	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	556						integral to membrane	protein binding				0																		---	---	---	---
EMILIN1	11117	broad.mit.edu	37	2	27305042	27305042	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27305042A>G	uc002rii.3	+	4	1031	c.603A>G	c.(601-603)GGA>GGG	p.G201G	EMILIN1_uc010eyq.1_Silent_p.G201G|EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	201					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ABHD1	84696	broad.mit.edu	37	2	27351433	27351433	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27351433T>C	uc002rit.2	+	2	399	c.239T>C	c.(238-240)GTC>GCC	p.V80A	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_Intron	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	80						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
SLC5A6	8884	broad.mit.edu	37	2	27430127	27430127	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27430127T>C	uc002rjd.2	-	3	783	c.392A>G	c.(391-393)GAG>GGG	p.E131G	SLC5A6_uc010eyv.1_Missense_Mutation_p.E131G|SLC5A6_uc002rje.1_Missense_Mutation_p.E131G	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	131					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)													---	---	---	---
C2orf28	51374	broad.mit.edu	37	2	27439752	27439752	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27439752C>A	uc002rjf.2	+	7	964	c.791C>A	c.(790-792)GCC>GAC	p.A264D	C2orf28_uc002rjg.2_Missense_Mutation_p.A151D|C2orf28_uc002rjh.2_RNA|CAD_uc002rji.2_5'Flank|CAD_uc010eyw.2_5'Flank	NM_080592	NP_542159	Q6UW56	APR3_HUMAN	apoptosis related protein 3 isoform b	209	Helical; (Potential).					integral to membrane|plasma membrane				skin(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
CAD	790	broad.mit.edu	37	2	27444118	27444118	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27444118A>G	uc002rji.2	+	3	417	c.255A>G	c.(253-255)GCA>GCG	p.A85A	CAD_uc010eyw.2_Silent_p.A85A	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	85	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)													---	---	---	---
SNX17	9784	broad.mit.edu	37	2	27598544	27598544	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27598544A>G	uc002rkg.1	+	10	1168	c.946A>G	c.(946-948)ACC>GCC	p.T316A	SNX17_uc010ylj.1_Missense_Mutation_p.T296A|SNX17_uc010ylk.1_Missense_Mutation_p.T102A|SNX17_uc010eza.1_Missense_Mutation_p.T102A|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_Missense_Mutation_p.T102A|SNX17_uc010yll.1_Missense_Mutation_p.T102A|SNX17_uc010ylm.1_Missense_Mutation_p.T102A|SNX17_uc010yln.1_Missense_Mutation_p.T304A|SNX17_uc010ylo.1_Missense_Mutation_p.T234A|SNX17_uc010ylp.1_Missense_Mutation_p.T291A|SNX17_uc010ylq.1_Missense_Mutation_p.T102A	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	316					cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27670413	27670413	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27670413G>A	uc002rku.2	-	42	4679	c.4628C>T	c.(4627-4629)ACG>ATG	p.T1543M	IFT172_uc010ezb.2_RNA	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1543					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
C2orf16	84226	broad.mit.edu	37	2	27802997	27802997	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27802997A>G	uc002rkz.3	+	1	3609	c.3558A>G	c.(3556-3558)AGA>AGG	p.R1186R	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1186										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
GPN1	11321	broad.mit.edu	37	2	27854759	27854759	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27854759T>C	uc010ymc.1	+	4	367	c.346T>C	c.(346-348)TTT>CTT	p.F116L	ZNF512_uc010yly.1_RNA|CCDC121_uc002rle.2_5'Flank|GPN1_uc010ezf.2_Missense_Mutation_p.F90L|GPN1_uc010yma.1_Missense_Mutation_p.F23L|GPN1_uc010ymb.1_Intron|GPN1_uc010ymd.1_Intron|GPN1_uc010yme.1_Missense_Mutation_p.F116L|GPN1_uc010ezg.1_Intron	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	102						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
MRPL33	9553	broad.mit.edu	37	2	27994648	27994648	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27994648T>C	uc002rlm.1	+	1	65	c.4T>C	c.(4-6)TTC>CTC	p.F2L	MRPL33_uc002rln.1_Missense_Mutation_p.F2L	NM_004891	NP_004882	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33 isoform a	2					translation	mitochondrion|ribosome	structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
RBKS	64080	broad.mit.edu	37	2	28081321	28081321	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28081321C>T	uc002rlo.1	-	2	218	c.207G>A	c.(205-207)ACG>ACA	p.T69T	RBKS_uc010ezi.1_Silent_p.T2T|RBKS_uc010ymg.1_Silent_p.T69T	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	69					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
FOSL2	2355	broad.mit.edu	37	2	28631696	28631696	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28631696G>A	uc002rma.2	+	3	1234	c.425G>A	c.(424-426)CGG>CAG	p.R142Q	FOSL2_uc010ymi.1_Missense_Mutation_p.R103Q	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	142	Basic motif.				cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
WDR43	23160	broad.mit.edu	37	2	29124900	29124900	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29124900T>C	uc002rmo.2	+	2	305	c.273T>C	c.(271-273)AGT>AGC	p.S91S		NM_015131	NP_055946	Q15061	WDR43_HUMAN	WD repeat domain 43	91	WD 2.					nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
ALK	238	broad.mit.edu	37	2	29498087	29498087	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29498087C>T	uc002rmy.2	-	11	2826	c.1919G>A	c.(1918-1920)GGA>GAA	p.G640E		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	640	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---	---
LCLAT1	253558	broad.mit.edu	37	2	30756115	30756115	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:30756115G>A	uc002rnj.2	+	4	622	c.413G>A	c.(412-414)CGA>CAA	p.R138Q	LCLAT1_uc010ymp.1_5'UTR|LCLAT1_uc002rnk.1_Missense_Mutation_p.R138Q|LCLAT1_uc002rnl.2_Missense_Mutation_p.R100Q|LCLAT1_uc010ymq.1_Missense_Mutation_p.R100Q	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	138					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2																		---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32658760	32658760	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32658760T>C	uc010ezu.2	+	13	3431	c.3297T>C	c.(3295-3297)TGT>TGC	p.C1099C		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1099					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32664624	32664624	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32664624T>C	uc010ezu.2	+	16	3814	c.3680T>C	c.(3679-3681)GTG>GCG	p.V1227A		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1227					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32667130	32667130	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32667130T>C	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33586574	33586574	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33586574A>G	uc002ros.2	+	28	4265	c.4265A>G	c.(4264-4266)AAC>AGC	p.N1422S	LTBP1_uc002rot.2_Missense_Mutation_p.N1096S|LTBP1_uc002rou.2_Missense_Mutation_p.N1095S|LTBP1_uc002rov.2_Missense_Mutation_p.N1042S|LTBP1_uc010ymz.1_Missense_Mutation_p.N1053S|LTBP1_uc010yna.1_Missense_Mutation_p.N1000S|LTBP1_uc010ynb.1_Missense_Mutation_p.N319S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1421					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33586588	33586588	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33586588A>G	uc002ros.2	+						LTBP1_uc002rot.2_Intron|LTBP1_uc002rou.2_Intron|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826			latent transforming growth factor beta binding						negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
VIT	5212	broad.mit.edu	37	2	36970392	36970392	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:36970392G>A	uc002rpl.2	+	4	489	c.268G>A	c.(268-270)GTA>ATA	p.V90I	VIT_uc002rpk.2_Missense_Mutation_p.V83I|VIT_uc010ynf.1_Missense_Mutation_p.V83I|VIT_uc002rpm.2_Missense_Mutation_p.V83I|VIT_uc010ezv.2_Missense_Mutation_p.V83I|VIT_uc010ezw.2_Missense_Mutation_p.V83I	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	90	LCCL.					proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)																---	---	---	---
QPCT	25797	broad.mit.edu	37	2	37594397	37594397	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37594397A>T	uc002rqg.2	+	4	691	c.569A>T	c.(568-570)GAT>GTT	p.D190V	QPCT_uc002rqh.2_Missense_Mutation_p.D141V	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	190					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)																---	---	---	---
FAM82A1	151393	broad.mit.edu	37	2	38231304	38231304	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38231304A>G	uc002rql.2	+	10	1247	c.1124A>G	c.(1123-1125)CAG>CGG	p.Q375R	FAM82A1_uc002rqn.1_Missense_Mutation_p.Q553R|FAM82A1_uc002rqm.2_Missense_Mutation_p.Q230R	NM_144713	NP_653314	Q96LZ7	RMD2_HUMAN	family with sequence similarity 82, member A1	375						cytoplasm|integral to membrane|microtubule|spindle pole	binding			ovary(1)	1																		---	---	---	---
ATL2	64225	broad.mit.edu	37	2	38525536	38525536	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38525536T>C	uc002rqq.2	-	12	1412	c.1382A>G	c.(1381-1383)AAG>AGG	p.K461R	ATL2_uc010ynm.1_Missense_Mutation_p.K443R|ATL2_uc010ynn.1_Missense_Mutation_p.K443R|ATL2_uc010yno.1_Missense_Mutation_p.K290R|ATL2_uc002rqs.2_Missense_Mutation_p.K461R|ATL2_uc002rqr.2_Missense_Mutation_p.K290R	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	461	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
GALM	130589	broad.mit.edu	37	2	38959063	38959063	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38959063G>A	uc002rqy.2	+							NM_138801	NP_620156			galactose mutarotase						hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)																---	---	---	---
SOS1	6654	broad.mit.edu	37	2	39237753	39237753	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39237753T>C	uc002rrk.3	-	15	2523	c.2482A>G	c.(2482-2484)ACC>GCC	p.T828A	SOS1_uc002rrj.3_Missense_Mutation_p.T442A	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	828	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)												Noonan_syndrome				---	---	---	---
CDKL4	344387	broad.mit.edu	37	2	39431662	39431662	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39431662A>G	uc002rrm.2	-						CDKL4_uc010fal.1_Intron	NM_001009565	NP_001009565			cyclin-dependent kinase-like 4							cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)																---	---	---	---
COX7A2L	9167	broad.mit.edu	37	2	42578469	42578469	+	Nonsense_Mutation	SNP	G	A	A	rs61754513		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42578469G>A	uc002rsk.2	-	3	290	c.235C>T	c.(235-237)CGA>TGA	p.R79*	COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709	O14548	COX7R_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	79					respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0																		---	---	---	---
LRPPRC	10128	broad.mit.edu	37	2	44187750	44187750	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44187750A>G	uc002rtr.2	-	13	1570	c.1512T>C	c.(1510-1512)AGT>AGC	p.S504S	LRPPRC_uc010yob.1_Silent_p.S404S	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	504					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
SIX2	10736	broad.mit.edu	37	2	45236051	45236051	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:45236051A>G	uc002ruo.2	-	1	492	c.199T>C	c.(199-201)TAC>CAC	p.Y67H	SIX2_uc002rup.2_Missense_Mutation_p.Y67H	NM_016932	NP_058628	Q9NPC8	SIX2_HUMAN	SIX homeobox 2	67						nucleus	sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
MSH6	2956	broad.mit.edu	37	2	48027122	48027122	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48027122A>T	uc002rwd.3	+	4	2152	c.2000A>T	c.(1999-2001)GAT>GTT	p.D667V	MSH6_uc002rwc.2_Missense_Mutation_p.D667V|MSH6_uc010fbj.2_Missense_Mutation_p.D365V|MSH6_uc010yoi.1_Missense_Mutation_p.D537V|MSH6_uc010yoj.1_Missense_Mutation_p.D365V	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	667					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)					Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
MSH6	2956	broad.mit.edu	37	2	48027725	48027725	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48027725T>C	uc002rwd.3	+	4	2755	c.2603T>C	c.(2602-2604)ATG>ACG	p.M868T	MSH6_uc002rwc.2_Missense_Mutation_p.M868T|MSH6_uc010fbj.2_Missense_Mutation_p.M566T|MSH6_uc010yoi.1_Missense_Mutation_p.M738T|MSH6_uc010yoj.1_Missense_Mutation_p.M566T	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	868					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)					Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48808756	48808756	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48808756T>C	uc010yol.1	+	1	1031	c.984T>C	c.(982-984)TGT>TGC	p.C328C	STON1_uc002rwo.3_Silent_p.C328C|STON1_uc010fbm.2_Silent_p.C328C|STON1-GTF2A1L_uc002rwp.1_Silent_p.C328C|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Silent_p.C328C	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	328					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)															---	---	---	---
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48872208	48872208	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48872208G>A	uc010yol.1	+						STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.G818S|GTF2A1L_uc002rws.1_Missense_Mutation_p.G114S|GTF2A1L_uc010yom.1_Missense_Mutation_p.G80S|GTF2A1L_uc002rwt.2_Missense_Mutation_p.G114S	NM_006873	NP_006864			stonin 1						endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)															---	---	---	---
FSHR	2492	broad.mit.edu	37	2	49190230	49190230	+	Missense_Mutation	SNP	A	G	G	rs113877695		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:49190230A>G	uc002rww.2	-	10	1804	c.1730T>C	c.(1729-1731)CTC>CCC	p.L577P	FSHR_uc002rwx.2_Missense_Mutation_p.L515P|FSHR_uc010fbn.2_Missense_Mutation_p.L551P	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	577	Helical; Name=6; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)									Gonadal_Dysgenesis_46_XX				---	---	---	---
NRXN1	9378	broad.mit.edu	37	2	50464031	50464031	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:50464031G>A	uc010fbp.2	-	2	1144	c.337C>T	c.(337-339)CGA>TGA	p.R113*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.R820*|NRXN1_uc010fbq.2_Nonsense_Mutation_p.R1188*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.R1148*|NRXN1_uc002rxc.1_RNA	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	113	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)															---	---	---	---
NRXN1	9378	broad.mit.edu	37	2	50723239	50723239	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:50723239A>G	uc010fbq.2	-						NRXN1_uc002rxb.3_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_001135659	NP_001129131			neurexin 1 isoform alpha2 precursor						angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)															---	---	---	---
NRXN1	9378	broad.mit.edu	37	2	51254957	51254957	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:51254957C>T	uc010fbq.2	-	2	1932	c.455G>A	c.(454-456)GGC>GAC	p.G152D	NRXN1_uc002rxe.3_Missense_Mutation_p.G152D|NRXN1_uc002rxd.1_Missense_Mutation_p.G152D	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54125072	54125072	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54125072A>G	uc002rxp.2	-	31	3597	c.3541T>C	c.(3541-3543)TTG>CTG	p.L1181L	PSME4_uc010yop.1_Silent_p.L1067L|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Silent_p.L556L|PSME4_uc010fbv.1_Silent_p.L325L	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1181	HEAT 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
SPTBN1	6711	broad.mit.edu	37	2	54873365	54873365	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54873365G>A	uc002rxu.2	+	23	4868	c.4619G>A	c.(4618-4620)CGC>CAC	p.R1540H	SPTBN1_uc002rxx.2_Missense_Mutation_p.R1527H	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1540	Spectrin 12.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)															---	---	---	---
C2orf63	130162	broad.mit.edu	37	2	55449384	55449384	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55449384T>C	uc002ryi.2	-	3	510	c.164A>G	c.(163-165)AAT>AGT	p.N55S	C2orf63_uc002ryh.2_5'UTR|C2orf63_uc002ryj.2_Intron	NM_152385	NP_689598	Q8NHS4	CB063_HUMAN	hypothetical protein LOC130162 isoform 1	55							binding			ovary(2)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(58;0.179)|Lung(47;0.189)															---	---	---	---
MTIF2	4528	broad.mit.edu	37	2	55470795	55470795	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55470795G>A	uc002ryn.2	-	13	2058	c.1321C>T	c.(1321-1323)CGT>TGT	p.R441C	MTIF2_uc010yox.1_Missense_Mutation_p.R110C|MTIF2_uc002ryo.2_Missense_Mutation_p.R441C	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	441					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1																		---	---	---	---
CCDC88A	55704	broad.mit.edu	37	2	55573429	55573429	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55573429T>C	uc002ryv.2	-	10	1765	c.923A>G	c.(922-924)TAC>TGC	p.Y308C	CCDC88A_uc010yoz.1_Missense_Mutation_p.Y308C|CCDC88A_uc010ypa.1_Missense_Mutation_p.Y308C|CCDC88A_uc010ypb.1_Missense_Mutation_p.Y210C	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	308	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4																		---	---	---	---
PAPOLG	64895	broad.mit.edu	37	2	61019297	61019297	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61019297G>T	uc002sai.2	+	17	1783	c.1552G>T	c.(1552-1554)GGA>TGA	p.G518*	PAPOLG_uc002saj.2_Nonsense_Mutation_p.G207*|PAPOLG_uc002sak.2_Nonsense_Mutation_p.G53*|PAPOLG_uc010fch.2_Nonsense_Mutation_p.G207*	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	518					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)															---	---	---	---
COMMD1	150684	broad.mit.edu	37	2	62228080	62228080	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:62228080T>C	uc002sbp.2	+	2	436	c.425T>C	c.(424-426)GTT>GCT	p.V142A	COMMD1_uc002sbq.1_RNA	NM_152516	NP_689729	Q8N668	COMD1_HUMAN	MURR1	142	COMM.				copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			ovary(1)	1	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)															---	---	---	---
EHBP1	23301	broad.mit.edu	37	2	62991483	62991483	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:62991483T>C	uc002sby.2	+	4	727	c.245T>C	c.(244-246)GTA>GCA	p.V82A	EHBP1_uc010fcp.2_Missense_Mutation_p.V82A|EHBP1_uc010fcq.1_Missense_Mutation_p.V82A|EHBP1_uc002sbx.2_Missense_Mutation_p.V82A|EHBP1_uc002sbz.2_Missense_Mutation_p.V82A|EHBP1_uc002scb.2_Missense_Mutation_p.V82A|EHBP1_uc002sca.2_Missense_Mutation_p.V82A	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	82						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)											Hereditary_Prostate_Cancer				---	---	---	---
EHBP1	23301	broad.mit.edu	37	2	63092036	63092036	+	Missense_Mutation	SNP	A	C	C	rs139208941		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63092036A>C	uc002sby.2	+	10	1515	c.1033A>C	c.(1033-1035)ATA>CTA	p.I345L	EHBP1_uc010fcp.2_Missense_Mutation_p.I310L|EHBP1_uc002sbx.2_Missense_Mutation_p.I310L|EHBP1_uc002sbz.2_Missense_Mutation_p.I310L|EHBP1_uc002scb.2_Missense_Mutation_p.I310L	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	345						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)											Hereditary_Prostate_Cancer				---	---	---	---
EHBP1	23301	broad.mit.edu	37	2	63176256	63176256	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63176256A>G	uc002sby.2	+	14	2862	c.2380A>G	c.(2380-2382)ACC>GCC	p.T794A	EHBP1_uc010fcp.2_Missense_Mutation_p.T759A|EHBP1_uc002sbz.2_Missense_Mutation_p.T759A|EHBP1_uc002scb.2_Missense_Mutation_p.T759A	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	794						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)											Hereditary_Prostate_Cancer				---	---	---	---
C2orf86	51057	broad.mit.edu	37	2	63631685	63631685	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63631685C>T	uc002sch.2	-	10	1379	c.933G>A	c.(931-933)GAG>GAA	p.E311E	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Silent_p.E152E|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Silent_p.E119E|C2orf86_uc002sci.1_Silent_p.E287E|C2orf86_uc010fcr.1_Silent_p.E201E	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	311					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0																		---	---	---	---
MDH1	4190	broad.mit.edu	37	2	63832446	63832446	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:63832446G>T	uc002scj.1	+	7	764	c.708G>T	c.(706-708)AAG>AAT	p.K236N	MDH1_uc010ypv.1_Missense_Mutation_p.K254N|MDH1_uc010ypw.1_Missense_Mutation_p.K141N	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase	236					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)													---	---	---	---
AFTPH	54812	broad.mit.edu	37	2	64779360	64779360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64779360C>T	uc002sdc.2	+	1	784	c.752C>T	c.(751-753)GCA>GTA	p.A251V	AFTPH_uc002scz.2_Missense_Mutation_p.A251V|AFTPH_uc002sda.2_Missense_Mutation_p.A251V|AFTPH_uc002sdb.2_Missense_Mutation_p.A251V	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	251					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2																		---	---	---	---
ACTR2	10097	broad.mit.edu	37	2	65482703	65482703	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:65482703T>C	uc002sdq.2	+	6	825	c.610T>C	c.(610-612)TTC>CTC	p.F204L	ACTR2_uc010yqf.1_Missense_Mutation_p.F149L|ACTR2_uc002sdp.2_Missense_Mutation_p.F209L|ACTR2_uc010yqg.1_Missense_Mutation_p.F152L	NM_005722	NP_005713	P61160	ARP2_HUMAN	actin-related protein 2 isoform b	204					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding				0																		---	---	---	---
ADD2	119	broad.mit.edu	37	2	70915174	70915174	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:70915174C>A	uc002sgz.2	-	9	1395	c.930G>T	c.(928-930)CAG>CAT	p.Q310H	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Missense_Mutation_p.Q310H|ADD2_uc002sha.2_Intron|ADD2_uc002sgx.2_Missense_Mutation_p.Q310H|ADD2_uc010fdt.1_Missense_Mutation_p.Q310H|ADD2_uc002shc.1_Missense_Mutation_p.Q310H|ADD2_uc002shd.1_Intron|ADD2_uc010fdu.1_Missense_Mutation_p.Q326H	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	310					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3																		---	---	---	---
ATP6V1B1	525	broad.mit.edu	37	2	71163109	71163109	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71163109C>T	uc002shj.2	+	1	112	c.25C>T	c.(25-27)CCT>TCT	p.P9S	ATP6V1B1_uc002shi.1_Missense_Mutation_p.P9S|ATP6V1B1_uc010fdv.2_Missense_Mutation_p.P9S|ATP6V1B1_uc010fdw.2_RNA	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	9					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1																		---	---	---	---
ATP6V1B1	525	broad.mit.edu	37	2	71187158	71187158	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71187158C>A	uc002shj.2	+	6	622	c.535C>A	c.(535-537)CGC>AGC	p.R179S	ATP6V1B1_uc002shi.1_Missense_Mutation_p.R179S|ATP6V1B1_uc010fdv.2_Missense_Mutation_p.R179S|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.R137S	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	179					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1																		---	---	---	---
ZNF638	27332	broad.mit.edu	37	2	71576963	71576963	+	Missense_Mutation	SNP	G	A	A	rs141176451		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71576963G>A	uc002shx.2	+	2	1198	c.879G>A	c.(877-879)ATG>ATA	p.M293I	ZNF638_uc010fec.2_Missense_Mutation_p.M399I|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.M293I|ZNF638_uc002shy.2_Missense_Mutation_p.M293I|ZNF638_uc002shz.2_Missense_Mutation_p.M293I|ZNF638_uc002sia.2_Missense_Mutation_p.M293I|ZNF638_uc002sib.1_Missense_Mutation_p.M293I	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	293					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4																		---	---	---	---
DYSF	8291	broad.mit.edu	37	2	71788894	71788894	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71788894T>C	uc002sie.2	+	23	2551	c.2175T>C	c.(2173-2175)GGT>GGC	p.G725G	DYSF_uc010feg.2_Silent_p.G756G|DYSF_uc010feh.2_Silent_p.G711G|DYSF_uc002sig.3_Silent_p.G711G|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.G725G|DYSF_uc010fef.2_Silent_p.G742G|DYSF_uc010fei.2_Silent_p.G742G|DYSF_uc010fek.2_Silent_p.G743G|DYSF_uc010fej.2_Silent_p.G712G|DYSF_uc010fel.2_Silent_p.G712G|DYSF_uc010feo.2_Silent_p.G757G|DYSF_uc010fem.2_Silent_p.G726G|DYSF_uc010fen.2_Silent_p.G743G|DYSF_uc002sif.2_Silent_p.G726G	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	725	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7																		---	---	---	---
SFXN5	94097	broad.mit.edu	37	2	73195648	73195648	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73195648C>T	uc002siq.2	-	12	887	c.756G>A	c.(754-756)ACG>ACA	p.T252T	SFXN5_uc002sio.2_Silent_p.T144T|SFXN5_uc010yrc.1_Silent_p.T101T|SFXN5_uc002sip.2_RNA|SFXN5_uc010fet.2_Intron|SFXN5_uc010fer.2_RNA|SFXN5_uc010feq.2_Silent_p.T34T|SFXN5_uc010fes.2_Silent_p.T34T	NM_144579	NP_653180	Q8TD22	SFXN5_HUMAN	sideroflexin 5	252					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			ovary(1)	1																		---	---	---	---
C2orf7	84279	broad.mit.edu	37	2	73455993	73455993	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73455993C>T	uc002siy.2	-	4	444	c.376G>A	c.(376-378)GTG>ATG	p.V126M		NM_032319	NP_115695	Q9BSG0	PADC1_HUMAN	chromosome 2 open reading frame 7 precursor	126	PA.					extracellular region					0																		---	---	---	---
CCT7	10574	broad.mit.edu	37	2	73479961	73479961	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73479961G>A	uc002siz.2	+	12	1706	c.1604G>A	c.(1603-1605)CGG>CAG	p.R535Q	CCT7_uc002sja.2_Missense_Mutation_p.R331Q|CCT7_uc010yrf.1_Missense_Mutation_p.R491Q|CCT7_uc010feu.2_Missense_Mutation_p.R493Q|CCT7_uc010yrg.1_Missense_Mutation_p.R435Q|CCT7_uc010yrh.1_Missense_Mutation_p.R407Q|CCT7_uc010yri.1_Missense_Mutation_p.R448Q	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	535					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73651914	73651914	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73651914A>G	uc002sje.1	+	6	1235	c.1124A>G	c.(1123-1125)GAC>GGC	p.D375G	ALMS1_uc002sjf.1_Missense_Mutation_p.D332G	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	374					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
MTHFD2	10797	broad.mit.edu	37	2	74438395	74438395	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74438395C>T	uc002skk.2	+	6	819	c.740C>T	c.(739-741)GCA>GTA	p.A247V	MTHFD2_uc002skj.2_Missense_Mutation_p.A145V|MTHFD2_uc010yro.1_Missense_Mutation_p.A145V|MTHFD2_uc010ffb.2_Missense_Mutation_p.A206V|MTHFD2_uc010yrp.1_Missense_Mutation_p.A83V	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	247					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)													---	---	---	---
SLC4A5	57835	broad.mit.edu	37	2	74474176	74474176	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74474176G>A	uc002sko.1	-	14	2048	c.2046C>T	c.(2044-2046)GTC>GTT	p.V682V	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.V682V|SLC4A5_uc010ffc.1_Silent_p.V682V|SLC4A5_uc002skp.1_Silent_p.V618V|SLC4A5_uc002sks.1_Silent_p.V682V	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	682	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9																		---	---	---	---
DCTN1	1639	broad.mit.edu	37	2	74597614	74597614	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74597614C>T	uc002skx.2	-	11	1417	c.1106G>A	c.(1105-1107)CGC>CAC	p.R369H	DCTN1_uc002skv.2_Missense_Mutation_p.R235H|DCTN1_uc002sku.2_Missense_Mutation_p.R235H|DCTN1_uc002skw.1_Missense_Mutation_p.R345H|DCTN1_uc010ffd.2_Missense_Mutation_p.R349H|DCTN1_uc002sky.2_Missense_Mutation_p.R332H	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	369	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5																		---	---	---	---
RTKN	6242	broad.mit.edu	37	2	74654556	74654556	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74654556T>C	uc002sle.2	-	10	1367	c.1250A>G	c.(1249-1251)GAC>GGC	p.D417G	RTKN_uc002slc.2_Missense_Mutation_p.D404G|RTKN_uc002sld.2_Missense_Mutation_p.D367G	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	417					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1																		---	---	---	---
MOGS	7841	broad.mit.edu	37	2	74688480	74688480	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74688480G>A	uc010ffj.2	-	4	2599	c.2436C>T	c.(2434-2436)CGC>CGT	p.R812R	MOGS_uc010ffh.2_Silent_p.R537R|MOGS_uc010yrt.1_Silent_p.R693R|MOGS_uc010ffi.2_Silent_p.R706R	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	812	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0																		---	---	---	---
MOGS	7841	broad.mit.edu	37	2	74691666	74691666	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74691666T>G	uc010ffj.2	-	2	699	c.536A>C	c.(535-537)CAG>CCG	p.Q179P	MOGS_uc010ffh.2_5'Flank|MOGS_uc010yrt.1_Missense_Mutation_p.Q60P|MOGS_uc010ffi.2_Missense_Mutation_p.Q73P|MOGS_uc010yru.1_Intron	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	179	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0																		---	---	---	---
AUP1	550	broad.mit.edu	37	2	74756004	74756004	+	3'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74756004T>C	uc010yry.1	-	3					DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Missense_Mutation_p.N133S|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.N42S|AUP1_uc010yrx.1_Missense_Mutation_p.N190S|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank					SubName: Full=cDNA FLJ58836, highly similar to Ancient ubiquitous protein 1;							endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0																		---	---	---	---
TACR1	6869	broad.mit.edu	37	2	75425766	75425766	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:75425766A>G	uc002sng.2	-	1	880	c.295T>C	c.(295-297)TAC>CAC	p.Y99H	TACR1_uc002snh.2_Missense_Mutation_p.Y99H	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	99	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)													---	---	---	---
LRRTM4	80059	broad.mit.edu	37	2	77745646	77745646	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:77745646T>C	uc002snr.2	-	3	1764	c.1349A>G	c.(1348-1350)TAC>TGC	p.Y450C	LRRTM4_uc002snq.2_Missense_Mutation_p.Y450C|LRRTM4_uc002sns.2_Missense_Mutation_p.Y450C|LRRTM4_uc002snt.2_Missense_Mutation_p.Y451C	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	450	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)														---	---	---	---
CTNNA2	1496	broad.mit.edu	37	2	80816514	80816514	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:80816514A>C	uc010ysh.1	+	14	2098	c.2093A>C	c.(2092-2094)GAT>GCT	p.D698A	CTNNA2_uc010yse.1_Missense_Mutation_p.D698A|CTNNA2_uc010ysf.1_Missense_Mutation_p.D698A|CTNNA2_uc010ysg.1_Missense_Mutation_p.D698A|CTNNA2_uc010ysi.1_Missense_Mutation_p.D330A|CTNNA2_uc010ysj.1_Missense_Mutation_p.D27A	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	698					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
RETSAT	54884	broad.mit.edu	37	2	85571218	85571218	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85571218C>A	uc002spd.2	-	9	1628	c.1437G>T	c.(1435-1437)AAG>AAT	p.K479N	RETSAT_uc010fge.2_Intron|RETSAT_uc010ysm.1_Missense_Mutation_p.K418N|RETSAT_uc010fgf.2_Missense_Mutation_p.K270N	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	479					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)													---	---	---	---
RETSAT	54884	broad.mit.edu	37	2	85571464	85571464	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85571464G>A	uc002spd.2	-	8	1455	c.1264C>T	c.(1264-1266)CGC>TGC	p.R422C	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.R361C|RETSAT_uc010fgf.2_Missense_Mutation_p.R213C	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	422					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)													---	---	---	---
SH2D6	284948	broad.mit.edu	37	2	85662598	85662598	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85662598T>C	uc002spq.2	+	2	392	c.231T>C	c.(229-231)AGT>AGC	p.S77S	SH2D6_uc002spo.2_Intron|SH2D6_uc002spp.2_RNA	NM_198482	NP_940884	Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	77	SH2.									central_nervous_system(1)	1																		---	---	---	---
PTCD3	55037	broad.mit.edu	37	2	86352118	86352118	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86352118A>G	uc002sqw.2	+	10	783	c.717A>G	c.(715-717)CGA>CGG	p.R239R	PTCD3_uc010ytc.1_RNA|PTCD3_uc002sqx.1_5'UTR	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	239						mitochondrion	protein binding			ovary(1)	1																		---	---	---	---
REEP1	65055	broad.mit.edu	37	2	86479109	86479109	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86479109C>T	uc002srh.3	-	5	532	c.388G>A	c.(388-390)GCC>ACC	p.A130T	REEP1_uc010ytg.1_Missense_Mutation_p.A109T|REEP1_uc010yth.1_Missense_Mutation_p.A103T|REEP1_uc010yti.1_Intron	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	130					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0																		---	---	---	---
KDM3A	55818	broad.mit.edu	37	2	86691166	86691166	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86691166T>C	uc002sri.3	+						KDM3A_uc010ytj.1_Intron|KDM3A_uc010ytk.1_Intron	NM_018433	NP_060903			jumonji domain containing 1A						androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
C2orf51	200523	broad.mit.edu	37	2	88828868	88828868	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88828868A>G	uc002stb.1	+	4	561	c.419A>G	c.(418-420)CAC>CGC	p.H140R		NM_152670	NP_689883	Q96LM6	TSC21_HUMAN	chromosome 2 open reading frame 51	140						nucleus				skin(1)	1																		---	---	---	---
EIF2AK3	9451	broad.mit.edu	37	2	88885403	88885403	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88885403T>C	uc002stc.3	-	9	1808	c.1606A>G	c.(1606-1608)ACA>GCA	p.T536A		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	536	Cytoplasmic (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	89291960	89291960	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89291960T>C	uc010ytr.1	-	82		c.7246A>G			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	89292029	89292029	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89292029A>G	uc010ytr.1	-	82		c.7177T>C			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	89545016	89545016	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89545016T>C	uc010ytr.1	-	13		c.1595A>G			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	90109091	90109091	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:90109091T>C	uc010fhm.2	+											Parts of antibodies, mostly variable regions.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	90260033	90260033	+	RNA	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:90260033C>T	uc010fhm.2	+	30		c.4016C>T								Parts of antibodies, mostly variable regions.																														---	---	---	---
TEKT4	150483	broad.mit.edu	37	2	95537557	95537557	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95537557C>T	uc002stw.1	+	1	326	c.233C>T	c.(232-234)GCG>GTG	p.A78V	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	78					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
MAL	4118	broad.mit.edu	37	2	95719178	95719178	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95719178T>C	uc002stx.1	+	4	499	c.440T>C	c.(439-441)TTA>TCA	p.L147S	MAL_uc002sty.1_Missense_Mutation_p.L91S|MAL_uc002stz.1_Missense_Mutation_p.L105S|MAL_uc002sua.1_Missense_Mutation_p.L49S	NM_002371	NP_002362	P21145	MAL_HUMAN	T-lymphocyte maturation-associated protein	147	Helical; (Potential).|MARVEL.				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath				0				STAD - Stomach adenocarcinoma(1183;0.18)														---	---	---	---
ZNF2	7549	broad.mit.edu	37	2	95847341	95847341	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95847341A>G	uc002suf.2	+	6	1227	c.765A>G	c.(763-765)AAA>AAG	p.K255K	ZNF2_uc002sug.2_Silent_p.K213K|ZNF2_uc010yue.1_Silent_p.K218K|ZNF2_uc010fhs.2_Silent_p.K176K	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	255					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)														---	---	---	---
ARID5A	10865	broad.mit.edu	37	2	97216987	97216987	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97216987G>A	uc002swe.2	+	7	822	c.722G>A	c.(721-723)CGG>CAG	p.R241Q	ARID5A_uc010yuq.1_Missense_Mutation_p.R189Q|ARID5A_uc002swf.2_Missense_Mutation_p.R77Q|ARID5A_uc002swg.2_Missense_Mutation_p.R189Q	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	241					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0																		---	---	---	---
LMAN2L	81562	broad.mit.edu	37	2	97377619	97377619	+	Silent	SNP	G	A	A	rs143337559	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97377619G>A	uc002swu.2	-	5	687	c.651C>T	c.(649-651)TAC>TAT	p.Y217Y	LMAN2L_uc002swv.2_Silent_p.Y228Y|LMAN2L_uc010yut.1_Silent_p.Y83Y|LMAN2L_uc010yuu.1_Silent_p.Y81Y|LMAN2L_uc010yuv.1_Silent_p.Y70Y|LMAN2L_uc010yuw.1_Silent_p.Y72Y|LMAN2L_uc002sww.2_Silent_p.Y70Y|LMAN2L_uc010yux.1_Silent_p.Y72Y	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	217	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0																		---	---	---	---
CNNM4	26504	broad.mit.edu	37	2	97427380	97427380	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97427380G>A	uc002swx.2	+	1	742	c.644G>A	c.(643-645)CGC>CAC	p.R215H		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	215	DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3																		---	---	---	---
SEMA4C	54910	broad.mit.edu	37	2	97530013	97530013	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:97530013G>A	uc002sxh.3	-	10	1229	c.1069C>T	c.(1069-1071)CGC>TGC	p.R357C	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Missense_Mutation_p.R410C	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	357	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2																		---	---	---	---
ACTR1B	10120	broad.mit.edu	37	2	98275421	98275421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98275421G>A	uc002syb.2	-	5	569	c.361C>T	c.(361-363)CGG>TGG	p.R121W		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	121						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1																		---	---	---	---
ZAP70	7535	broad.mit.edu	37	2	98354253	98354253	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98354253T>C	uc002syd.1	+	12	1723	c.1516T>C	c.(1516-1518)TAC>CAC	p.Y506H	ZAP70_uc002sye.1_Missense_Mutation_p.Y396H|ZAP70_uc002syf.1_Missense_Mutation_p.Y199H	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	506	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6																		---	---	---	---
TMEM131	23505	broad.mit.edu	37	2	98411544	98411544	+	Missense_Mutation	SNP	G	A	A	rs61753932		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98411544G>A	uc002syh.3	-	29	3464	c.3235C>T	c.(3235-3237)CGG>TGG	p.R1079W		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1079						integral to membrane				ovary(4)|central_nervous_system(2)	6																		---	---	---	---
VWA3B	200403	broad.mit.edu	37	2	98872590	98872590	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98872590C>A	uc002syo.2	+	21	3060	c.2796C>A	c.(2794-2796)CGC>CGA	p.R932R	VWA3B_uc002sym.2_Silent_p.R932R|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Silent_p.R589R|VWA3B_uc002syp.1_Silent_p.R324R|VWA3B_uc002syq.1_Silent_p.R208R|VWA3B_uc002syr.1_Silent_p.R249R|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	932										ovary(3)|large_intestine(2)|skin(1)	6																		---	---	---	---
CNGA3	1261	broad.mit.edu	37	2	99006150	99006150	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99006150T>C	uc002syt.2	+	6	896	c.479T>C	c.(478-480)GTG>GCG	p.V160A	CNGA3_uc002syu.2_Missense_Mutation_p.V142A|CNGA3_uc010fij.2_Missense_Mutation_p.V164A	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	160					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6																		---	---	---	---
C2orf55	343990	broad.mit.edu	37	2	99454683	99454683	+	Silent	SNP	C	T	T	rs147976810	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99454683C>T	uc002szf.1	-	3	432	c.138G>A	c.(136-138)CCG>CCA	p.P46P		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	46											0																		---	---	---	---
TSGA10	80705	broad.mit.edu	37	2	99636888	99636888	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99636888C>T	uc002szg.3	-	16	2300	c.1672G>A	c.(1672-1674)GCA>ACA	p.A558T	TSGA10_uc002szh.3_Missense_Mutation_p.A558T|TSGA10_uc002szi.3_Missense_Mutation_p.A558T|TSGA10_uc010fin.1_Missense_Mutation_p.A558T	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	558	Interaction with HIF1A (By similarity).				spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MITD1	129531	broad.mit.edu	37	2	99787981	99787981	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99787981T>C	uc002szs.1	-	3	430	c.382A>G	c.(382-384)ACT>GCT	p.T128A	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	128					protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2																		---	---	---	---
LYG1	129530	broad.mit.edu	37	2	99909004	99909004	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99909004T>C	uc002szy.2	-	4	393	c.143A>G	c.(142-144)TAC>TGC	p.Y48C	MRPL30_uc002szl.1_Intron|LYG1_uc010yvo.1_Missense_Mutation_p.Y48C	NM_174898	NP_777558	Q8N1E2	LYG1_HUMAN	lysozyme g-like protein 1 precursor	48					cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity				0																		---	---	---	---
EIF5B	9669	broad.mit.edu	37	2	100009567	100009567	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100009567T>C	uc002tab.2	+						EIF5B_uc010yvq.1_5'Flank	NM_015904	NP_056988			eukaryotic translation initiation factor 5B						regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
AFF3	3899	broad.mit.edu	37	2	100175428	100175428	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100175428T>C	uc002tag.2	-	21	3430	c.3194A>G	c.(3193-3195)TAC>TGC	p.Y1065C	AFF3_uc002taf.2_Missense_Mutation_p.Y1090C	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1065					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6																OREG0014830	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MAP4K4	9448	broad.mit.edu	37	2	102314966	102314966	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:102314966T>C	uc002tbg.2	+	2	144	c.89T>C	c.(88-90)GTG>GCG	p.V30A	MAP4K4_uc002tbc.2_Missense_Mutation_p.V30A|MAP4K4_uc002tbd.2_Missense_Mutation_p.V30A|MAP4K4_uc002tbe.2_Missense_Mutation_p.V30A|MAP4K4_uc002tbf.2_Missense_Mutation_p.V30A|MAP4K4_uc010yvy.1_Missense_Mutation_p.V30A|MAP4K4_uc002tbh.2_Missense_Mutation_p.V30A|MAP4K4_uc002tbi.2_Missense_Mutation_p.V30A	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	30	Protein kinase.				intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
SLC9A4	389015	broad.mit.edu	37	2	103119969	103119969	+	Silent	SNP	C	T	T	rs147197838		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103119969C>T	uc002tbz.3	+	3	1240	c.783C>T	c.(781-783)GTC>GTT	p.V261V		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	261	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3																		---	---	---	---
SLC9A4	389015	broad.mit.edu	37	2	103121775	103121775	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103121775A>G	uc002tbz.3	+	4	1500	c.1043A>G	c.(1042-1044)TAC>TGC	p.Y348C		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	348	Extracellular (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3																		---	---	---	---
UXS1	80146	broad.mit.edu	37	2	106761834	106761834	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106761834C>T	uc002tdm.2	-						UXS1_uc002tdn.2_Intron|UXS1_uc002tdo.2_Intron|UXS1_uc010ywh.1_Intron	NM_025076	NP_079352			UDP-glucuronate decarboxylase 1						cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2																		---	---	---	---
SULT1C4	27233	broad.mit.edu	37	2	108998284	108998284	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:108998284G>A	uc002tea.1	+	2	609	c.236G>A	c.(235-237)CGG>CAG	p.R79Q	SULT1C4_uc002tdz.2_Missense_Mutation_p.R79Q|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Missense_Mutation_p.R79Q	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	79					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0																		---	---	---	---
GCC2	9648	broad.mit.edu	37	2	109102288	109102288	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109102288A>G	uc002tec.2	+	15	3870	c.3716A>G	c.(3715-3717)GAA>GGA	p.E1239G	GCC2_uc002ted.2_Missense_Mutation_p.E1138G	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1239	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109367911	109367911	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109367911G>T	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109371486	109371486	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109371486A>G	uc002tem.3	+	16	2454	c.2328A>G	c.(2326-2328)AAA>AAG	p.K776K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	776					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
CCDC138	165055	broad.mit.edu	37	2	109490018	109490018	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109490018T>C	uc002ten.1	+	14	1865	c.1805T>C	c.(1804-1806)ATT>ACT	p.I602T	CCDC138_uc002teo.1_Intron|CCDC138_uc002tep.1_Missense_Mutation_p.I286T|CCDC138_uc010fjm.1_Intron	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	602											0																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112614259	112614259	+	Intron	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112614259A>T	uc002thi.2	-							NM_022662	NP_073153			anaphase promoting complex subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
TMEM87B	84910	broad.mit.edu	37	2	112817574	112817574	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112817574T>A	uc002thm.2	+	2	555	c.186T>A	c.(184-186)TTT>TTA	p.F62L	TMEM87B_uc010fkg.2_Missense_Mutation_p.F62L|TMEM87B_uc010fkh.2_Missense_Mutation_p.F62L	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	62						integral to membrane					0																		---	---	---	---
TMEM87B	84910	broad.mit.edu	37	2	112824632	112824632	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112824632T>C	uc002thm.2	+	4	807	c.438T>C	c.(436-438)TTT>TTC	p.F146F	TMEM87B_uc010fkg.2_Silent_p.F146F|TMEM87B_uc010fkh.2_Silent_p.F146F	NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	146						integral to membrane					0																		---	---	---	---
ZC3H6	376940	broad.mit.edu	37	2	113080227	113080227	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113080227T>C	uc002thq.1	+	9	1482	c.1088T>C	c.(1087-1089)GTG>GCG	p.V363A		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	363	Potential.						nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
POLR1B	84172	broad.mit.edu	37	2	113304624	113304624	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113304624G>A	uc002thw.2	+	2	793	c.213G>A	c.(211-213)GAG>GAA	p.E71E	POLR1B_uc010fkn.2_Intron|POLR1B_uc002thx.2_5'UTR|POLR1B_uc010fko.2_Silent_p.E71E|POLR1B_uc010fkp.2_Intron|POLR1B_uc010yxn.1_Silent_p.E109E|POLR1B_uc002thy.2_Intron|POLR1B_uc010yxo.1_Intron	NM_019014	NP_061887	Q9H9Y6	RPA2_HUMAN	RNA polymerase I polypeptide B isoform 1	71					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(1)	1																		---	---	---	---
SLC20A1	6574	broad.mit.edu	37	2	113417111	113417111	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113417111G>A	uc002tib.2	+	8	1825	c.1379G>A	c.(1378-1380)CGA>CAA	p.R460Q	SLC20A1_uc002tic.1_Missense_Mutation_p.R272Q	NM_005415	NP_005406	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate	460	Cytoplasmic (Potential).				phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			ovary(2)	2																		---	---	---	---
CKAP2L	150468	broad.mit.edu	37	2	113504147	113504147	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113504147T>C	uc002tie.2	-	6	1687	c.1608A>G	c.(1606-1608)GTA>GTG	p.V536V	CKAP2L_uc002tif.2_Silent_p.V125V|CKAP2L_uc010yxp.1_Silent_p.V371V	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	536						centrosome					0																		---	---	---	---
CKAP2L	150468	broad.mit.edu	37	2	113509871	113509871	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113509871C>T	uc002tie.2	-	5	1654	c.1575G>A	c.(1573-1575)CTG>CTA	p.L525L	CKAP2L_uc002tif.2_Silent_p.L114L|CKAP2L_uc010yxp.1_Silent_p.L360L|CKAP2L_uc010yxq.1_Silent_p.L360L	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	525						centrosome					0																		---	---	---	---
RABL2A	11159	broad.mit.edu	37	2	114398540	114398540	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114398540A>G	uc002tkn.3	+	6	581	c.367A>G	c.(367-369)AGG>GGG	p.R123G	RABL2A_uc010flb.2_Missense_Mutation_p.R123G|RABL2A_uc002tkl.3_Intron|RABL2A_uc002tkm.3_Intron|RABL2A_uc002tks.3_Missense_Mutation_p.R123G|RABL2A_uc002tkr.2_Missense_Mutation_p.R123G|RABL2A_uc002tkp.3_Missense_Mutation_p.R123G	NM_007082	NP_009013	Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	123					small GTPase mediated signal transduction		GTP binding|GTPase activity			skin(1)	1																		---	---	---	---
DDX18	8886	broad.mit.edu	37	2	118586976	118586976	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118586976A>G	uc002tlh.1	+	13	1903	c.1804A>G	c.(1804-1806)AAT>GAT	p.N602D		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	602							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
CCDC93	54520	broad.mit.edu	37	2	118701647	118701647	+	Missense_Mutation	SNP	G	A	A	rs142085524	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:118701647G>A	uc002tlj.2	-	18	1492	c.1366C>T	c.(1366-1368)CGG>TGG	p.R456W	CCDC93_uc010fld.1_Missense_Mutation_p.R456W	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	456										large_intestine(1)|ovary(1)	2																		---	---	---	---
TMEM177	80775	broad.mit.edu	37	2	120438936	120438936	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120438936C>T	uc010flg.1	+	2	980	c.507C>T	c.(505-507)CAC>CAT	p.H169H	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.H169H|TMEM177_uc002tmd.2_Silent_p.H169H|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	169	Helical; (Potential).					integral to membrane				ovary(1)	1	Colorectal(110;0.196)																	---	---	---	---
GLI2	2736	broad.mit.edu	37	2	121746705	121746705	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121746705C>T	uc010flp.2	+	13	3245	c.3215C>T	c.(3214-3216)GCG>GTG	p.A1072V	GLI2_uc002tmq.1_Missense_Mutation_p.A744V|GLI2_uc002tmr.1_Missense_Mutation_p.A727V|GLI2_uc002tmt.3_Missense_Mutation_p.A744V|GLI2_uc002tmu.3_Missense_Mutation_p.A727V	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1072					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)																---	---	---	---
TFCP2L1	29842	broad.mit.edu	37	2	122038815	122038815	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122038815T>C	uc002tmx.2	-	2	188	c.95A>G	c.(94-96)GAG>GGG	p.E32G	TFCP2L1_uc010flr.2_Missense_Mutation_p.E32G	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	32	Mediate transcriptional repression.				female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)																	---	---	---	---
MKI67IP	84365	broad.mit.edu	37	2	122493259	122493259	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122493259T>G	uc002tnk.2	-	2	250	c.173A>C	c.(172-174)GAA>GCA	p.E58A	MKI67IP_uc010fls.2_Missense_Mutation_p.E58A	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	58	RRM.				protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0																		---	---	---	---
MKI67IP	84365	broad.mit.edu	37	2	122494368	122494368	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122494368A>G	uc002tnk.2	-	1	136	c.59T>C	c.(58-60)GTC>GCC	p.V20A	MKI67IP_uc010fls.2_Missense_Mutation_p.V20A	NM_032390	NP_115766	Q9BYG3	MK67I_HUMAN	MKI67 interacting nucleolar phosphoprotein	20					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding				0																		---	---	---	---
CNTNAP5	129684	broad.mit.edu	37	2	125504828	125504828	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:125504828G>T	uc002tno.2	+	14	2461	c.2097G>T	c.(2095-2097)TGG>TGT	p.W699C	CNTNAP5_uc010flu.2_Missense_Mutation_p.W700C	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	699	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)														---	---	---	---
MYO7B	4648	broad.mit.edu	37	2	128389922	128389922	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128389922G>A	uc002top.2	+	38	5326	c.5273G>A	c.(5272-5274)CGG>CAG	p.R1758Q	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1758	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)														---	---	---	---
MYO7B	4648	broad.mit.edu	37	2	128389955	128389955	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128389955G>A	uc002top.2	+	38	5359	c.5306G>A	c.(5305-5307)CGC>CAC	p.R1769H	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1769	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)														---	---	---	---
WDR33	55339	broad.mit.edu	37	2	128525807	128525807	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128525807G>A	uc002tpg.1	-	4	517	c.334C>T	c.(334-336)CGG>TGG	p.R112W	WDR33_uc002tph.1_Missense_Mutation_p.R112W|WDR33_uc002tpi.1_Missense_Mutation_p.R112W	NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	112					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)														---	---	---	---
UGGT1	56886	broad.mit.edu	37	2	128934410	128934410	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128934410C>A	uc002tps.2	+	32	3740	c.3562C>A	c.(3562-3564)CCT>ACT	p.P1188T	UGGT1_uc002tpr.2_Missense_Mutation_p.P1164T	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1188					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
FAM123C	205147	broad.mit.edu	37	2	131520855	131520855	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131520855A>G	uc002trw.2	+	2	1400	c.1210A>G	c.(1210-1212)AGC>GGC	p.S404G	FAM123C_uc010fmv.2_Missense_Mutation_p.S404G|FAM123C_uc010fms.1_Missense_Mutation_p.S404G|FAM123C_uc010fmt.1_Missense_Mutation_p.S404G|FAM123C_uc010fmu.1_Missense_Mutation_p.S404G	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	404										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)														---	---	---	---
FAM123C	205147	broad.mit.edu	37	2	131521980	131521980	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131521980A>G	uc002trw.2	+	2	2525	c.2335A>G	c.(2335-2337)ACA>GCA	p.T779A	FAM123C_uc010fmv.2_Missense_Mutation_p.T779A|FAM123C_uc010fms.1_Missense_Mutation_p.T779A|FAM123C_uc010fmt.1_Missense_Mutation_p.T779A|FAM123C_uc010fmu.1_Missense_Mutation_p.T779A	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	779										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)														---	---	---	---
MGAT5	4249	broad.mit.edu	37	2	135185960	135185960	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135185960T>A	uc002ttv.1	+	14	1964	c.1819T>A	c.(1819-1821)TTT>ATT	p.F607I		NM_002410	NP_002401	Q09328	MGT5A_HUMAN	N-acetylglucosaminyltransferase V	607	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0964)														---	---	---	---
RAB3GAP1	22930	broad.mit.edu	37	2	135848570	135848570	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135848570T>C	uc002tuj.2	+	4	178	c.153T>C	c.(151-153)GGT>GGC	p.G51G	RAB3GAP1_uc010fnf.2_Silent_p.G51G|RAB3GAP1_uc010fng.2_5'UTR|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	51						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)														---	---	---	---
LCT	3938	broad.mit.edu	37	2	136548301	136548301	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136548301C>T	uc002tuu.1	-	15	5273	c.5262G>A	c.(5260-5262)CAG>CAA	p.Q1754Q		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1754	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)														---	---	---	---
CXCR4	7852	broad.mit.edu	37	2	136872772	136872772	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136872772G>A	uc002tuz.2	-	2	821	c.726C>T	c.(724-726)GTC>GTT	p.V242V	CXCR4_uc002tuy.2_Silent_p.V246V|CXCR4_uc010fnk.2_Silent_p.V227V	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	242	Helical; Name=6.			VIL -> IIP (in Ref. 12; AAK29630).	activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)													---	---	---	---
THSD7B	80731	broad.mit.edu	37	2	138169187	138169187	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:138169187A>G	uc002tva.1	+	13	2611	c.2611A>G	c.(2611-2613)AGA>GGA	p.R871G	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.R761G	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141232837	141232837	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141232837C>A	uc002tvj.1	-	60	10467	c.9495G>T	c.(9493-9495)CAG>CAT	p.Q3165H		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3165	Extracellular (Potential).|LDL-receptor class B 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141243084	141243084	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141243084T>C	uc002tvj.1	-	59	10225	c.9253A>G	c.(9253-9255)AAC>GAC	p.N3085D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3085	Extracellular (Potential).|LDL-receptor class B 28.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
KYNU	8942	broad.mit.edu	37	2	143718259	143718259	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:143718259G>A	uc002tvl.2	+	8	779	c.649G>A	c.(649-651)GTG>ATG	p.V217M	KYNU_uc002tvk.2_Missense_Mutation_p.V217M|KYNU_uc010fnm.2_Missense_Mutation_p.V217M	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	217					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)													---	---	---	---
ARHGAP15	55843	broad.mit.edu	37	2	143986243	143986243	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:143986243T>C	uc002tvm.3	+						ARHGAP15_uc010zbl.1_Intron	NM_018460	NP_060930			ARHGAP15						regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)														---	---	---	---
ARHGAP15	55843	broad.mit.edu	37	2	144525621	144525621	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144525621T>C	uc002tvm.3	+	14	1459	c.1308T>C	c.(1306-1308)CCT>CCC	p.P436P	ARHGAP15_uc002tvn.2_Silent_p.P202P	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	436	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)														---	---	---	---
ORC4L	5000	broad.mit.edu	37	2	148693233	148693233	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148693233T>C	uc002twi.2	-	14	1292	c.1157A>G	c.(1156-1158)AAG>AGG	p.K386R	ORC4L_uc002twj.2_Missense_Mutation_p.K386R|ORC4L_uc010zbo.1_Missense_Mutation_p.K312R|ORC4L_uc010zbp.1_Missense_Mutation_p.K169R|ORC4L_uc010fnr.2_3'UTR|ORC4L_uc010zbq.1_Missense_Mutation_p.K302R|ORC4L_uc002twk.2_Missense_Mutation_p.K386R|ORC4L_uc002twl.1_RNA	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	386					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)														---	---	---	---
ORC4L	5000	broad.mit.edu	37	2	148733504	148733504	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148733504A>G	uc002twi.2	-	2	159	c.24T>C	c.(22-24)AGT>AGC	p.S8S	ORC4L_uc002twj.2_Silent_p.S8S|ORC4L_uc010zbo.1_Intron|ORC4L_uc010zbp.1_5'UTR|ORC4L_uc010fnr.2_Silent_p.S8S|ORC4L_uc010zbq.1_Intron|ORC4L_uc002twk.2_Silent_p.S8S|ORC4L_uc010zbr.1_Silent_p.S8S	NM_181741	NP_859525	O43929	ORC4_HUMAN	origin recognition complex subunit 4	8					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|nucleoside-triphosphatase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.0963)|COAD - Colon adenocarcinoma(177;0.203)														---	---	---	---
MBD5	55777	broad.mit.edu	37	2	149247708	149247708	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:149247708A>G	uc002twm.3	+	12	4796	c.3808A>G	c.(3808-3810)AAA>GAA	p.K1270E	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.K1270E|MBD5_uc002two.2_Missense_Mutation_p.K528E|MBD5_uc002twp.2_Missense_Mutation_p.K320E	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1270						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)														---	---	---	---
NMI	9111	broad.mit.edu	37	2	152139394	152139394	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152139394A>G	uc002txi.2	-	2	399	c.69T>C	c.(67-69)GAT>GAC	p.D23D	NMI_uc010zbx.1_Silent_p.D23D|NMI_uc002txj.2_Silent_p.D23D	NM_004688	NP_004679	Q13287	NMI_HUMAN	N-myc and STAT interactor	23					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity				0				BRCA - Breast invasive adenocarcinoma(221;0.0571)														---	---	---	---
RIF1	55183	broad.mit.edu	37	2	152321218	152321218	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152321218A>T	uc002txm.2	+	30	5314	c.5184A>T	c.(5182-5184)AGA>AGT	p.R1728S	RIF1_uc002txl.2_Missense_Mutation_p.R1728S|RIF1_uc002txn.2_Missense_Mutation_p.R1728S|RIF1_uc002txo.2_Missense_Mutation_p.R1728S|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1728					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152476094	152476094	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152476094G>A	uc010fnx.2	-	69	10205	c.10014C>T	c.(10012-10014)ATC>ATT	p.I3338I		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3338	Nebulin 91.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152584353	152584353	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152584353T>C	uc010fnx.2	-	5	337	c.146A>G	c.(145-147)AAA>AGA	p.K49R		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	49					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
FMNL2	114793	broad.mit.edu	37	2	153192179	153192179	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153192179T>C	uc002tye.2	+	1	429	c.62T>C	c.(61-63)TTG>TCG	p.L21S		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	21					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3																		---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153514439	153514439	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153514439T>C	uc002tyh.3	-	25	2686	c.2664A>G	c.(2662-2664)AAA>AAG	p.K888K	PRPF40A_uc002tyg.3_Silent_p.K344K|PRPF40A_uc010zcd.1_Silent_p.K839K	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	915					mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
NR4A2	4929	broad.mit.edu	37	2	157185874	157185874	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:157185874G>A	uc002tyz.3	-	3	1247	c.825C>T	c.(823-825)TAC>TAT	p.Y275Y	NR4A2_uc002tyx.3_Silent_p.Y212Y|NR4A2_uc010zcf.1_Silent_p.Y275Y|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	275	NR C4-type.|Nuclear receptor.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3																		---	---	---	---
GALNT5	11227	broad.mit.edu	37	2	158152254	158152254	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158152254A>G	uc002tzg.2	+	4	2076	c.1821A>G	c.(1819-1821)TTA>TTG	p.L607L	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	607	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4																		---	---	---	---
ERMN	57471	broad.mit.edu	37	2	158182017	158182017	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158182017T>C	uc002tzh.2	-	1	400	c.138A>G	c.(136-138)GAA>GAG	p.E46E	ERMN_uc010zcj.1_5'Flank|ERMN_uc010zck.1_Silent_p.E46E|ERMN_uc002tzi.2_Silent_p.E59E	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	46						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2																		---	---	---	---
CYTIP	9595	broad.mit.edu	37	2	158287107	158287107	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158287107A>C	uc002tzj.1	-	5	512	c.440T>G	c.(439-441)GTC>GGC	p.V147G	CYTIP_uc010zcl.1_Missense_Mutation_p.V41G	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	147	PDZ.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
ACVR1C	130399	broad.mit.edu	37	2	158412846	158412846	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158412846T>C	uc002tzk.3	-	3	548	c.305_splice	c.e3-1	p.A102_splice	ACVR1C_uc002tzl.3_Intron|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Splice_Site_p.A52_splice	NM_145259	NP_660302			activin A receptor, type IC isoform 1						apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7																		---	---	---	---
ACVR1	90	broad.mit.edu	37	2	158594106	158594106	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158594106C>A	uc002tzm.3	-	12	1806	c.1467G>T	c.(1465-1467)CTG>CTT	p.L489L	ACVR1_uc002tzn.3_Silent_p.L489L|ACVR1_uc010fog.2_Silent_p.L489L	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	489	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
UPP2	151531	broad.mit.edu	37	2	158971625	158971625	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158971625G>A	uc002tzp.2	+	3	387	c.193G>A	c.(193-195)GGT>AGT	p.G65S	UPP2_uc002tzo.2_Missense_Mutation_p.G122S	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	65					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0																		---	---	---	---
PKP4	8502	broad.mit.edu	37	2	159517885	159517885	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159517885C>T	uc002tzv.2	+	13	2394	c.2134C>T	c.(2134-2136)CGG>TGG	p.R712W	PKP4_uc002tzt.1_Missense_Mutation_p.R564W|PKP4_uc002tzu.2_Missense_Mutation_p.R712W|PKP4_uc002tzw.2_Missense_Mutation_p.R712W|PKP4_uc002tzx.2_Missense_Mutation_p.R369W|PKP4_uc002tzy.1_Missense_Mutation_p.R370W|PKP4_uc002uaa.2_Missense_Mutation_p.R564W|uc002uab.1_RNA|PKP4_uc002uac.2_5'Flank	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	712	ARM 6.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7															HNSCC(62;0.18)			---	---	---	---
PKP4	8502	broad.mit.edu	37	2	159519604	159519604	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159519604A>G	uc002tzv.2	+						PKP4_uc002tzu.2_Intron|PKP4_uc002tzw.2_Intron|PKP4_uc002tzx.2_Intron|PKP4_uc002uaa.2_Intron|uc002uab.1_Intron|PKP4_uc002uac.2_Intron	NM_003628	NP_003619			plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7															HNSCC(62;0.18)			---	---	---	---
LY75	4065	broad.mit.edu	37	2	160691985	160691985	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160691985A>G	uc002ubc.3	-						LY75_uc002ubb.3_Intron|LY75_uc010fos.2_Intron	NM_002349	NP_002340			lymphocyte antigen 75 precursor						endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)														---	---	---	---
LY75	4065	broad.mit.edu	37	2	160738648	160738648	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160738648T>C	uc002ubc.3	-	7	1302	c.1233A>G	c.(1231-1233)AAA>AAG	p.K411K	LY75_uc002ubb.3_Silent_p.K411K|LY75_uc010fos.2_Silent_p.K411K|LY75_uc010fot.1_Silent_p.K411K	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	411	C-type lectin 2.|Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)														---	---	---	---
RBMS1	5937	broad.mit.edu	37	2	161133827	161133827	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:161133827G>A	uc002ubo.2	-	12	1574	c.1130C>T	c.(1129-1131)GCG>GTG	p.A377V	RBMS1_uc002ubj.2_Missense_Mutation_p.A357V|RBMS1_uc002ubk.2_Missense_Mutation_p.A341V|RBMS1_uc002ubl.2_Missense_Mutation_p.A372V|RBMS1_uc002ubn.2_Missense_Mutation_p.A374V|RBMS1_uc002ubi.3_Missense_Mutation_p.A390V|RBMS1_uc002ubm.2_Missense_Mutation_p.A360V|RBMS1_uc002ubp.2_Missense_Mutation_p.A393V	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	377					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0																		---	---	---	---
RBMS1	5937	broad.mit.edu	37	2	161135111	161135111	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:161135111A>G	uc002ubo.2	-	11	1454	c.1010T>C	c.(1009-1011)ATC>ACC	p.I337T	RBMS1_uc002ubj.2_Missense_Mutation_p.I317T|RBMS1_uc002ubk.2_Missense_Mutation_p.I301T|RBMS1_uc002ubl.2_Missense_Mutation_p.I332T|RBMS1_uc002ubn.2_Missense_Mutation_p.I334T|RBMS1_uc002ubi.3_Missense_Mutation_p.I350T|RBMS1_uc002ubm.2_Missense_Mutation_p.I320T|RBMS1_uc002ubp.2_Missense_Mutation_p.I353T	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	337					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0																OREG0015036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RBMS1	5937	broad.mit.edu	37	2	161141508	161141508	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:161141508G>A	uc002ubo.2	-	8	1248	c.804C>T	c.(802-804)AAC>AAT	p.N268N	RBMS1_uc002ubj.2_Silent_p.N232N|RBMS1_uc002ubk.2_Silent_p.N232N|RBMS1_uc002ubl.2_Silent_p.N263N|RBMS1_uc002ubn.2_Silent_p.N265N|RBMS1_uc002ubi.3_Silent_p.N265N|RBMS1_uc002ubm.2_Silent_p.N235N|RBMS1_uc002ubp.2_Silent_p.N268N|RBMS1_uc010fox.2_Silent_p.N268N	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	268					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0																		---	---	---	---
PSMD14	10213	broad.mit.edu	37	2	162224420	162224420	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162224420T>C	uc002ubu.2	+							NM_005805	NP_005796			proteasome 26S subunit, non-ATPase 14						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)	1																		---	---	---	---
TBR1	10716	broad.mit.edu	37	2	162273269	162273269	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162273269G>A	uc002ubw.1	+	1	650	c.348G>A	c.(346-348)GCG>GCA	p.A116A	TBR1_uc010foy.2_5'Flank	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	116						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TBR1	10716	broad.mit.edu	37	2	162275431	162275431	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162275431A>G	uc002ubw.1	+	4	1300	c.998A>G	c.(997-999)TAC>TGC	p.Y333C	TBR1_uc010foy.2_Missense_Mutation_p.Y46C	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	333	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GCG	2641	broad.mit.edu	37	2	163002048	163002048	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163002048A>G	uc002ucc.2	-	4	491	c.392_splice	c.e4+1	p.D131_splice		NM_002054	NP_002045			glucagon preproprotein						cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)													---	---	---	---
KCNH7	90134	broad.mit.edu	37	2	163230092	163230092	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163230092T>C	uc002uch.1	-	15	3424	c.3212A>G	c.(3211-3213)TAC>TGC	p.Y1071C		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	1071	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)													---	---	---	---
KCNH7	90134	broad.mit.edu	37	2	163393494	163393494	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:163393494T>C	uc002uch.1	-	3	616	c.404A>G	c.(403-405)AAT>AGT	p.N135S	KCNH7_uc002uci.2_Missense_Mutation_p.N135S	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	135	Cytoplasmic (Potential).|PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)													---	---	---	---
FIGN	55137	broad.mit.edu	37	2	164467285	164467285	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:164467285C>T	uc002uck.1	-	3	1368	c.1057G>A	c.(1057-1059)GAC>AAC	p.D353N		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	353						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4																		---	---	---	---
XIRP2	129446	broad.mit.edu	37	2	168105878	168105878	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168105878T>C	uc002udx.2	+	8	7994	c.7976T>C	c.(7975-7977)GTT>GCT	p.V2659A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V2484A|XIRP2_uc010fpq.2_Missense_Mutation_p.V2437A|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.V5A	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2484					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14																		---	---	---	---
STK39	27347	broad.mit.edu	37	2	168931518	168931518	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:168931518G>A	uc002uea.2	-	12	1376	c.1216C>T	c.(1216-1218)CGA>TGA	p.R406*		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	406					response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170044660	170044660	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170044660C>T	uc002ues.2	-	49	9361	c.9148G>A	c.(9148-9150)GTC>ATC	p.V3050I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3050	LDL-receptor class A 24.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.V3050I(1)		ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170097525	170097525	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170097525T>C	uc002ues.2	-	25	4231	c.4018A>G	c.(4018-4020)AAT>GAT	p.N1340D	LRP2_uc010zdf.1_Missense_Mutation_p.N1203D	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1340	LDL-receptor class A 15.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
FASTKD1	79675	broad.mit.edu	37	2	170413695	170413695	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170413695A>G	uc002uev.3	-	6	1470	c.1082_splice	c.e6+1	p.R361_splice	FASTKD1_uc002uew.3_Splice_Site|FASTKD1_uc002uex.3_Splice_Site_p.R347_splice	NM_024622	NP_078898			FAST kinase domains 1						apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4																		---	---	---	---
UBR3	130507	broad.mit.edu	37	2	170843155	170843155	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170843155A>T	uc010zdi.1	+	25	3635	c.3635A>T	c.(3634-3636)GAT>GTT	p.D1212V	UBR3_uc002ufr.3_Intron|UBR3_uc010fqa.2_Missense_Mutation_p.D33V|UBR3_uc002uft.3_Missense_Mutation_p.D65V	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1212					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
SP5	389058	broad.mit.edu	37	2	171572883	171572883	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171572883C>T	uc002uge.2	+	2	332	c.166C>T	c.(166-168)CAG>TAG	p.Q56*	LOC440925_uc002ugd.2_5'Flank	NM_001003845	NP_001003845	Q6BEB4	SP5_HUMAN	Sp5 transcription factor	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
HAT1	8520	broad.mit.edu	37	2	172823402	172823402	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172823402A>G	uc002uhi.2	+	8	831	c.755A>G	c.(754-756)CAT>CGT	p.H252R	HAT1_uc010fqi.2_Missense_Mutation_p.H87R|HAT1_uc002uhj.2_Missense_Mutation_p.H167R	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	252					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
DLX2	1746	broad.mit.edu	37	2	172965310	172965310	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172965310G>A	uc002uhn.2	-	3	1160	c.948C>T	c.(946-948)GGC>GGT	p.G316G		NM_004405	NP_004396	Q07687	DLX2_HUMAN	distal-less homeobox 2	316	Poly-Gly.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
ZAK	51776	broad.mit.edu	37	2	174131421	174131421	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174131421C>T	uc002uhz.2	+	20	2546	c.2346C>T	c.(2344-2346)CCC>CCT	p.P782P	uc002uib.2_Intron	NM_016653	NP_057737	Q9NYL2	MLTK_HUMAN	MLK-related kinase isoform 1	782					activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
SP3	6670	broad.mit.edu	37	2	174819995	174819995	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174819995A>G	uc002uig.2	-	4	1409	c.1245T>C	c.(1243-1245)GGT>GGC	p.G415G	SP3_uc002uie.2_Silent_p.G347G|SP3_uc002uif.2_Silent_p.G362G|SP3_uc010zel.1_Silent_p.G412G	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	415	Transactivation domain (Gln-rich).				negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)															---	---	---	---
KIAA1715	80856	broad.mit.edu	37	2	176857025	176857025	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176857025C>T	uc002ukc.1	-	4	384	c.191G>A	c.(190-192)TGG>TAG	p.W64*	KIAA1715_uc010zer.1_Nonsense_Mutation_p.W64*|KIAA1715_uc010fqw.1_Nonsense_Mutation_p.W130*|KIAA1715_uc010zes.1_Intron|KIAA1715_uc002ukd.1_Intron|KIAA1715_uc010zet.1_RNA	NM_030650	NP_085153	Q9C0E8	LNP_HUMAN	Lunapark	64	Helical; (Potential).					integral to membrane	protein binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0793)															---	---	---	---
EVX2	344191	broad.mit.edu	37	2	176948405	176948405	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176948405T>C	uc010zeu.1	-	1	286	c.100A>G	c.(100-102)AAT>GAT	p.N34D		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	34						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)														---	---	---	---
HOXD9	3235	broad.mit.edu	37	2	176988303	176988303	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176988303A>G	uc010zex.1	+	1	891	c.807A>G	c.(805-807)CAA>CAG	p.Q269Q		NM_014213	NP_055028	P28356	HXD9_HUMAN	homeobox D9	269			Missing.			nucleus	sequence-specific DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)														---	---	---	---
HOXD4	3233	broad.mit.edu	37	2	177016792	177016792	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177016792C>T	uc002uks.2	+	1	680	c.431C>T	c.(430-432)TCG>TTG	p.S144L		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)														---	---	---	---
MTX2	10651	broad.mit.edu	37	2	177193105	177193105	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177193105A>G	uc002ukx.2	+	6	605	c.370A>G	c.(370-372)ACT>GCT	p.T124A	MTX2_uc002ukw.2_Missense_Mutation_p.T114A	NM_006554	NP_006545	O75431	MTX2_HUMAN	metaxin 2	124					protein targeting to mitochondrion	mitochondrial outer membrane				ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00365)|Epithelial(96;0.0654)|all cancers(119;0.181)															---	---	---	---
NFE2L2	4780	broad.mit.edu	37	2	178098751	178098751	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178098751T>G	uc002ulh.3	-	2	849	c.294A>C	c.(292-294)GGA>GGC	p.G98G	NFE2L2_uc002ulg.3_Silent_p.G82G|NFE2L2_uc010zfa.1_Silent_p.G82G|NFE2L2_uc002uli.3_Silent_p.G82G|NFE2L2_uc010fra.2_Silent_p.G82G|NFE2L2_uc010frb.2_Silent_p.G82G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	98					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)					Mis		NSCLC|HNSCC					HNSCC(56;0.16)			---	---	---	---
AGPS	8540	broad.mit.edu	37	2	178386079	178386079	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178386079G>A	uc002ull.2	+	18	1827	c.1780G>A	c.(1780-1782)GTA>ATA	p.V594I	AGPS_uc010zfb.1_Missense_Mutation_p.V504I	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	594					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)															---	---	---	---
RBM45	129831	broad.mit.edu	37	2	178977578	178977578	+	Intron	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:178977578G>C	uc002ulv.2	+							NM_152945	NP_694453			RNA binding motif protein 45						cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179395406	179395406	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179395406T>C	uc010zfg.1	-	307	98456	c.98232A>G	c.(98230-98232)TTA>TTG	p.L32744L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.L26439L|TTN_uc010zfi.1_Silent_p.L26372L|TTN_uc010zfj.1_Silent_p.L26247L|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33671							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179410270	179410270	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179410270C>T	uc010zfg.1	-	293	88087	c.87863G>A	c.(87862-87864)CGT>CAT	p.R29288H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R22983H|TTN_uc010zfi.1_Missense_Mutation_p.R22916H|TTN_uc010zfj.1_Missense_Mutation_p.R22791H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30215							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179425761	179425761	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179425761A>G	uc010zfg.1	-	275	77618	c.77394T>C	c.(77392-77394)GTT>GTC	p.V25798V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.V19493V|TTN_uc010zfi.1_Silent_p.V19426V|TTN_uc010zfj.1_Silent_p.V19301V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26725							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179426570	179426570	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179426570T>C	uc010zfg.1	-	275	76809	c.76585A>G	c.(76585-76587)ACC>GCC	p.T25529A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T19224A|TTN_uc010zfi.1_Missense_Mutation_p.T19157A|TTN_uc010zfj.1_Missense_Mutation_p.T19032A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26456							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R25529C(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179436182	179436182	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179436182T>C	uc010zfg.1	-	275	67197	c.66973A>G	c.(66973-66975)ACC>GCC	p.T22325A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T16020A|TTN_uc010zfi.1_Missense_Mutation_p.T15953A|TTN_uc010zfj.1_Missense_Mutation_p.T15828A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23252							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179440977	179440977	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179440977G>A	uc010zfg.1	-	275	62402	c.62178C>T	c.(62176-62178)ACC>ACT	p.T20726T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T14421T|TTN_uc010zfi.1_Silent_p.T14354T|TTN_uc010zfj.1_Silent_p.T14229T|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21653							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179446390	179446390	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179446390T>C	uc010zfg.1	-	265	59125	c.58901A>G	c.(58900-58902)AAC>AGC	p.N19634S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N13329S|TTN_uc010zfi.1_Missense_Mutation_p.N13262S|TTN_uc010zfj.1_Missense_Mutation_p.N13137S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20561							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179483496	179483496	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179483496T>C	uc010zfg.1	-	200	39301	c.39077A>G	c.(39076-39078)TAC>TGC	p.Y13026C	TTN_uc010zfh.1_Missense_Mutation_p.Y6721C|TTN_uc010zfi.1_Missense_Mutation_p.Y6654C|TTN_uc010zfj.1_Missense_Mutation_p.Y6529C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13953							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179497272	179497272	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179497272A>G	uc010zfg.1	-	184	35981	c.35757T>C	c.(35755-35757)AGT>AGC	p.S11919S	TTN_uc010zfh.1_Silent_p.S5614S|TTN_uc010zfi.1_Silent_p.S5547S|TTN_uc010zfj.1_Silent_p.S5422S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12846							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179515967	179515967	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179515967T>C	uc010zfg.1	-						TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_Intron|TTN_uc002umx.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179540660	179540660	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179540660G>A	uc010zfg.1	-	144	30846	c.30622C>T	c.(30622-30624)CCC>TCC	p.P10208S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6869S|TTN_uc010fre.1_Intron|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11135							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179553404	179553404	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179553404C>A	uc010zfg.1	-	123	28689	c.28465G>T	c.(28465-28467)GTA>TTA	p.V9489L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V6150L|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10416							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179575918	179575918	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179575918T>C	uc010zfg.1	-	94	24537	c.24313A>G	c.(24313-24315)ACA>GCA	p.T8105A	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T4766A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9032							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179593250	179593250	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179593250C>G	uc010zfg.1	-	63	15895	c.15671G>C	c.(15670-15672)TGT>TCT	p.C5224S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.C1885S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6151							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179616447	179616447	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179616447A>G	uc002unb.2	-	46	10904	c.10680T>C	c.(10678-10680)CAT>CAC	p.H3560H	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179640599	179640599	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179640599G>A	uc010zfg.1	-	28	6216	c.5992C>T	c.(5992-5994)CGC>TGC	p.R1998C	TTN_uc010zfh.1_Missense_Mutation_p.R1952C|TTN_uc010zfi.1_Missense_Mutation_p.R1952C|TTN_uc010zfj.1_Missense_Mutation_p.R1952C|TTN_uc002unb.2_Missense_Mutation_p.R1998C|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1998							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179659647	179659647	+	Splice_Site	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179659647A>C	uc010zfg.1	-	7	1469	c.1245_splice	c.e7+1	p.E415_splice	TTN_uc010zfh.1_Splice_Site_p.E415_splice|TTN_uc010zfi.1_Splice_Site_p.E415_splice|TTN_uc010zfj.1_Splice_Site_p.E415_splice|TTN_uc002unb.2_Splice_Site_p.E415_splice|TTN_uc010frg.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
SESTD1	91404	broad.mit.edu	37	2	179981458	179981458	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179981458G>A	uc002uni.3	-	15	1734	c.1584C>T	c.(1582-1584)GGC>GGT	p.G528G	SESTD1_uc002unh.3_5'UTR	NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	528	Spectrin 3.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)															---	---	---	---
UBE2E3	10477	broad.mit.edu	37	2	181927574	181927574	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:181927574G>A	uc002unq.1	+	7	802	c.583G>A	c.(583-585)GAC>AAC	p.D195N	UBE2E3_uc002unr.1_Missense_Mutation_p.D195N|UBE2E3_uc010fri.1_Missense_Mutation_p.D195N	NM_182678	NP_872619	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	195					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
ITGA4	3676	broad.mit.edu	37	2	182346369	182346369	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182346369G>A	uc002unu.2	+	7	1562	c.799G>A	c.(799-801)GAA>AAA	p.E267K	ITGA4_uc010zfl.1_Missense_Mutation_p.E267K	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	267	FG-GAP 4.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)													---	---	---	---
ITGA4	3676	broad.mit.edu	37	2	182358109	182358109	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182358109A>G	uc002unu.2	+	11	1974	c.1211A>G	c.(1210-1212)AAT>AGT	p.N404S		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	404	FG-GAP 6.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)													---	---	---	---
CERKL	375298	broad.mit.edu	37	2	182409416	182409416	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182409416A>G	uc002unx.2	-						CERKL_uc002uny.2_Intron|CERKL_uc010zfm.1_Intron|CERKL_uc002unz.2_Intron|CERKL_uc002uoa.2_Intron|CERKL_uc002uob.2_Intron|CERKL_uc002uoc.2_Intron|CERKL_uc010frk.2_Intron|CERKL_uc002unw.2_Intron	NM_001030311	NP_001025482			ceramide kinase-like isoform b						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)															---	---	---	---
SSFA2	6744	broad.mit.edu	37	2	182761698	182761698	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:182761698T>C	uc002uoi.2	+						SSFA2_uc002uoh.2_Intron|SSFA2_uc002uoj.2_Intron|SSFA2_uc002uok.2_Intron|SSFA2_uc010zfo.1_Intron|SSFA2_uc002uol.2_5'Flank	NM_001130445	NP_001123917			sperm specific antigen 2 isoform 1							cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)															---	---	---	---
FRZB	2487	broad.mit.edu	37	2	183730857	183730857	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183730857A>G	uc002upa.1	-	1	642	c.424T>C	c.(424-426)TAC>CAC	p.Y142H		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	142	FZ.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)															---	---	---	---
NCKAP1	10787	broad.mit.edu	37	2	183817966	183817966	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183817966T>C	uc002upc.2	-	21	2649	c.2247A>G	c.(2245-2247)GTA>GTG	p.V749V	NCKAP1_uc002upb.2_Silent_p.V755V	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	749					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
DUSP19	142679	broad.mit.edu	37	2	183951825	183951825	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183951825A>G	uc002upd.2	+	3	706	c.331A>G	c.(331-333)ACA>GCA	p.T111A	DUSP19_uc010frp.2_Intron|DUSP19_uc010zfr.1_RNA|DUSP19_uc002upe.2_Intron	NM_080876	NP_543152	Q8WTR2	DUS19_HUMAN	dual specificity phosphatase 19 isoform 1	111					JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|positive regulation of JNK cascade|positive regulation of JUN kinase activity	cytoplasm	JUN kinase phosphatase activity|MAP-kinase scaffold activity|mitogen-activated protein kinase kinase kinase binding|protein kinase activator activity|protein kinase inhibitor activity|protein tyrosine phosphatase activity			ovary(4)|pancreas(1)	5																		---	---	---	---
ZNF804A	91752	broad.mit.edu	37	2	185731181	185731181	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:185731181A>G	uc002uph.2	+	2	791	c.197A>G	c.(196-198)TAC>TGC	p.Y66C		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	66	C2H2-type.					intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	186678590	186678590	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:186678590A>G	uc002upm.2	+	2		c.3228A>G			uc010zfu.1_Missense_Mutation_p.S1214G					Homo sapiens cDNA FLJ44048 fis, clone TESTI4030669.																														---	---	---	---
ZC3H15	55854	broad.mit.edu	37	2	187360023	187360023	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187360023A>G	uc002upo.2	+	2	364	c.139A>G	c.(139-141)ACA>GCA	p.T47A		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	47						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)															---	---	---	---
FAM171B	165215	broad.mit.edu	37	2	187625956	187625956	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187625956T>C	uc002ups.2	+	7	1241	c.1129T>C	c.(1129-1131)TAT>CAT	p.Y377H	FAM171B_uc002upr.1_Missense_Mutation_p.Y377H|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	377	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10																		---	---	---	---
COL3A1	1281	broad.mit.edu	37	2	189850510	189850510	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189850510A>G	uc002uqj.1	+							NM_000090	NP_000081			collagen type III alpha 1 preproprotein						axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)													---	---	---	---
COL3A1	1281	broad.mit.edu	37	2	189873812	189873812	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189873812A>G	uc002uqj.1	+	48	3805	c.3688A>G	c.(3688-3690)AAC>GAC	p.N1230D		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1230					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)													---	---	---	---
COL5A2	1290	broad.mit.edu	37	2	189925450	189925450	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189925450A>G	uc002uqk.2	-						COL5A2_uc010frx.2_Intron	NM_000393	NP_000384			alpha 2 type V collagen preproprotein						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)															---	---	---	---
ANKAR	150709	broad.mit.edu	37	2	190608058	190608058	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190608058C>T	uc002uqw.1	+	20	3655	c.3655C>T	c.(3655-3657)CGC>TGC	p.R1219C	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Intron	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1290						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)															---	---	---	---
SDPR	8436	broad.mit.edu	37	2	192700728	192700728	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192700728G>A	uc002utb.2	-	2	1529	c.1199C>T	c.(1198-1200)GCG>GTG	p.A400V		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	400						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)													---	---	---	---
TMEFF2	23671	broad.mit.edu	37	2	192818525	192818525	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192818525T>C	uc002utc.2	-	9	1302	c.908A>G	c.(907-909)AAG>AGG	p.K303R		NM_016192	NP_057276	Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two	303	Required for shedding.|Extracellular (Potential).					extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)															---	---	---	---
SLC39A10	57181	broad.mit.edu	37	2	196593047	196593047	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196593047T>C	uc002utg.3	+	9	2525	c.2311T>C	c.(2311-2313)TTC>CTC	p.F771L	SLC39A10_uc002uth.3_Missense_Mutation_p.F771L|SLC39A10_uc010zgp.1_Missense_Mutation_p.F321L	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	771	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196640613	196640613	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196640613T>C	uc002utj.3	-	60	11260	c.11159A>G	c.(11158-11160)CAG>CGG	p.Q3720R	DNAH7_uc002uti.3_Missense_Mutation_p.Q203R	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3720					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196746539	196746539	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196746539C>A	uc002utj.3	-	36	6042	c.5941G>T	c.(5941-5943)GGG>TGG	p.G1981W		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1981	AAA 3 (By similarity).|ATP (Potential).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196765042	196765042	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196765042G>A	uc002utj.3	-	28	4613	c.4512C>T	c.(4510-4512)GCC>GCT	p.A1504A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1504	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196825620	196825620	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196825620A>G	uc002utj.3	-	18	2356	c.2255T>C	c.(2254-2256)GTA>GCA	p.V752A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	752	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
STK17B	9262	broad.mit.edu	37	2	197004484	197004484	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197004484T>C	uc002utk.2	-	7	1020	c.696A>G	c.(694-696)ACA>ACG	p.T232T	STK17B_uc010fsh.2_Silent_p.T232T	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	232	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)															---	---	---	---
STK17B	9262	broad.mit.edu	37	2	197021224	197021224	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197021224G>A	uc002utk.2	-	3	598	c.274C>T	c.(274-276)CGT>TGT	p.R92C	STK17B_uc010fsh.2_Missense_Mutation_p.R92C	NM_004226	NP_004217	O94768	ST17B_HUMAN	serine/threonine kinase 17B	92	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			lung(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.141)															---	---	---	---
HECW2	57520	broad.mit.edu	37	2	197298107	197298107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197298107C>T	uc002utm.1	-	2	224	c.41G>A	c.(40-42)CGT>CAT	p.R14H		NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	14					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18																		---	---	---	---
GTF3C3	9330	broad.mit.edu	37	2	197643670	197643670	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197643670A>G	uc002uts.2	-	10	1430	c.1340T>C	c.(1339-1341)CTT>CCT	p.L447P	GTF3C3_uc010zgu.1_Intron|GTF3C3_uc002utt.3_Missense_Mutation_p.L122P	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	447	TPR 7.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7																		---	---	---	---
GTF3C3	9330	broad.mit.edu	37	2	197662543	197662543	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:197662543G>T	uc002uts.2	-	2	282	c.192C>A	c.(190-192)TCC>TCA	p.S64S	GTF3C3_uc010zgu.1_Silent_p.S64S|GTF3C3_uc002utu.2_Silent_p.S64S	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	64						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7																		---	---	---	---
SF3B1	23451	broad.mit.edu	37	2	198268397	198268397	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198268397A>G	uc002uue.2	-	12	1679	c.1631T>C	c.(1630-1632)CTT>CCT	p.L544P		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	544	Interaction with SF3B14.|HEAT 1.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)															---	---	---	---
MOBKL3	25843	broad.mit.edu	37	2	198405143	198405143	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198405143T>A	uc002uun.3	+	5	376	c.336T>A	c.(334-336)GCT>GCA	p.A112A	MOBKL3_uc002uum.3_Silent_p.A80A|MOBKL3_uc010fsn.2_Silent_p.A91A|MOBKL3_uc010fso.2_Silent_p.A13A|MOBKL3_uc010zgz.1_Silent_p.A13A	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	112					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)															---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198953591	198953591	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198953591G>A	uc010fsp.2	+	3	3016	c.2725G>A	c.(2725-2727)GTG>ATG	p.V909M	PLCL1_uc002uuv.3_Missense_Mutation_p.V830M	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	909	Potential.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
PLCL1	5334	broad.mit.edu	37	2	198968586	198968586	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198968586G>T	uc010fsp.2	+	5	3322	c.3031G>T	c.(3031-3033)GCA>TCA	p.A1011S	PLCL1_uc002uuv.3_Missense_Mutation_p.A932S	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	1011					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)													---	---	---	---
SPATS2L	26010	broad.mit.edu	37	2	201304024	201304024	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201304024A>C	uc002uvn.3	+	7	977	c.625A>C	c.(625-627)AAG>CAG	p.K209Q	SPATS2L_uc010fst.2_Missense_Mutation_p.K209Q|SPATS2L_uc002uvo.3_Missense_Mutation_p.K149Q|SPATS2L_uc002uvp.3_Missense_Mutation_p.K209Q|SPATS2L_uc002uvq.3_Intron|SPATS2L_uc002uvr.3_Missense_Mutation_p.K209Q|SPATS2L_uc010zhc.1_Missense_Mutation_p.K239Q	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	209						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3																		---	---	---	---
SPATS2L	26010	broad.mit.edu	37	2	201332111	201332111	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201332111G>A	uc002uvn.3	+	10	1298	c.946G>A	c.(946-948)GCA>ACA	p.A316T	SPATS2L_uc010fst.2_Missense_Mutation_p.A316T|SPATS2L_uc002uvo.3_Missense_Mutation_p.A256T|SPATS2L_uc002uvp.3_Missense_Mutation_p.A316T|SPATS2L_uc002uvq.3_Missense_Mutation_p.A247T|SPATS2L_uc002uvr.3_Missense_Mutation_p.A316T|SPATS2L_uc010zhc.1_Missense_Mutation_p.A346T	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	316	Potential.					cytoplasm|nucleolus				ovary(2)|pancreas(1)	3																		---	---	---	---
NDUFB3	4709	broad.mit.edu	37	2	201950221	201950221	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201950221T>C	uc002uwx.3	+	3	503	c.180T>C	c.(178-180)AGT>AGC	p.S60S		NM_002491	NP_002482	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	60					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)													---	---	---	---
STRADB	55437	broad.mit.edu	37	2	202344807	202344807	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202344807A>G	uc002uyd.3	+	12	1531	c.1166A>G	c.(1165-1167)AAC>AGC	p.N389S		NM_018571	NP_061041	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	389					activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			skin(2)|stomach(1)|lung(1)	4																		---	---	---	---
SUMO1	7341	broad.mit.edu	37	2	203079166	203079166	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203079166A>C	uc002uyz.1	-						SUMO1_uc002uza.1_Intron	NM_001005781	NP_001005781			SMT3 suppressor of mif two 3 homolog 1 isoform a						DNA repair|interferon-gamma-mediated signaling pathway|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|palate development|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein complex assembly|protein sumoylation|regulation of interferon-gamma-mediated signaling pathway|regulation of protein localization	cytoplasm|nuclear membrane|nuclear pore|nuclear speck	ubiquitin protein ligase binding				0																		---	---	---	---
CYP20A1	57404	broad.mit.edu	37	2	204161589	204161589	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204161589A>G	uc002uzv.3	+	13	1969	c.1347A>G	c.(1345-1347)TCA>TCG	p.S449S	CYP20A1_uc002uzx.3_Silent_p.S347S|CYP20A1_uc010zif.1_Silent_p.S457S|CYP20A1_uc002uzy.3_Silent_p.S347S|CYP20A1_uc002uzw.3_RNA|CYP20A1_uc010ftw.2_Silent_p.S179S	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	449						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0																		---	---	---	---
RAPH1	65059	broad.mit.edu	37	2	204354576	204354576	+	Missense_Mutation	SNP	C	T	T	rs145036827	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204354576C>T	uc002vad.2	-	4	688	c.463G>A	c.(463-465)GAC>AAC	p.D155N	RAPH1_uc002vae.2_Missense_Mutation_p.D155N|RAPH1_uc002vaf.2_Missense_Mutation_p.D155N	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	155					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10																		---	---	---	---
NRP2	8828	broad.mit.edu	37	2	206580934	206580934	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206580934T>A	uc002vaw.2	+	3	1060	c.269T>A	c.(268-270)ATT>AAT	p.I90N	NRP2_uc002vat.2_Missense_Mutation_p.I90N|NRP2_uc002vau.2_Missense_Mutation_p.I90N|NRP2_uc002vav.2_Missense_Mutation_p.I90N|NRP2_uc002vax.2_Missense_Mutation_p.I90N|NRP2_uc002vay.2_Missense_Mutation_p.I90N|NRP2_uc010fud.2_Missense_Mutation_p.I90N	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	90	Extracellular (Potential).|CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
NRP2	8828	broad.mit.edu	37	2	206581054	206581054	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206581054G>A	uc002vaw.2	+	3	1180	c.389G>A	c.(388-390)CGG>CAG	p.R130Q	NRP2_uc002vat.2_Missense_Mutation_p.R130Q|NRP2_uc002vau.2_Missense_Mutation_p.R130Q|NRP2_uc002vav.2_Missense_Mutation_p.R130Q|NRP2_uc002vax.2_Missense_Mutation_p.R130Q|NRP2_uc002vay.2_Missense_Mutation_p.R130Q|NRP2_uc010fud.2_Missense_Mutation_p.R130Q	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	130	Extracellular (Potential).|CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
ZDBF2	57683	broad.mit.edu	37	2	207173178	207173178	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207173178T>C	uc002vbp.2	+	5	4176	c.3926T>C	c.(3925-3927)CTT>CCT	p.L1309P		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1309							nucleic acid binding|zinc ion binding			ovary(3)	3																		---	---	---	---
ADAM23	8745	broad.mit.edu	37	2	207426927	207426927	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207426927T>C	uc002vbq.2	+	13	1478	c.1255T>C	c.(1255-1257)TAT>CAT	p.Y419H	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	419	Peptidase M12B.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)														---	---	---	---
CCNYL1	151195	broad.mit.edu	37	2	208607011	208607011	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208607011T>C	uc002vci.2	+	5	788	c.431T>C	c.(430-432)GTT>GCT	p.V144A	CCNYL1_uc002vch.2_Missense_Mutation_p.V125A	NM_001142300	NP_001135772	Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1 isoform 1	195	Cyclin N-terminal.				regulation of cyclin-dependent protein kinase activity		protein kinase binding				0				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)														---	---	---	---
CRYGC	1420	broad.mit.edu	37	2	208994373	208994373	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208994373C>T	uc002vco.3	-	2	82	c.44G>A	c.(43-45)CGC>CAC	p.R15H		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	15	Beta/gamma crystallin 'Greek key' 1.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)														---	---	---	---
PIKFYVE	200576	broad.mit.edu	37	2	209150475	209150475	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209150475T>C	uc002vcz.2	+	6	797	c.639T>C	c.(637-639)TGT>TGC	p.C213C	PIKFYVE_uc010fun.1_5'UTR|PIKFYVE_uc002vcy.1_Silent_p.C213C|PIKFYVE_uc002vcv.2_Silent_p.C116C|PIKFYVE_uc002vcw.2_Silent_p.C213C|PIKFYVE_uc002vcx.2_Silent_p.C127C	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	213	FYVE-type.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10																		---	---	---	---
PIKFYVE	200576	broad.mit.edu	37	2	209200094	209200094	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:209200094G>A	uc002vcz.2	+	25	4365	c.4207G>A	c.(4207-4209)GCC>ACC	p.A1403T	PIKFYVE_uc002vcy.1_Missense_Mutation_p.A1347T	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1403					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10																		---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210560125	210560125	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210560125C>T	uc002vde.1	+	7	3479	c.3231C>T	c.(3229-3231)GAC>GAT	p.D1077D	MAP2_uc002vdc.1_Silent_p.D1077D|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.D1073D	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1077					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210594919	210594919	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210594919A>C	uc002vde.1	+	15	5530	c.5282A>C	c.(5281-5283)AAG>ACG	p.K1761T	MAP2_uc002vdd.1_Missense_Mutation_p.K493T|MAP2_uc002vdf.1_Missense_Mutation_p.K436T|MAP2_uc002vdg.1_Missense_Mutation_p.K405T|MAP2_uc002vdh.1_Missense_Mutation_p.K462T|MAP2_uc002vdi.1_Missense_Mutation_p.K1757T	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1761					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
LANCL1	10314	broad.mit.edu	37	2	211319864	211319864	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:211319864T>C	uc010zjh.1	-	4	449	c.374A>G	c.(373-375)AAC>AGC	p.N125S	LANCL1_uc002ved.2_Missense_Mutation_p.N125S|LANCL1_uc010fuq.2_Missense_Mutation_p.N125S	NM_001136574	NP_001130046	O43813	LANC1_HUMAN	lanthionine synthetase C-like protein 1	125						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding				0				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)														---	---	---	---
CPS1	1373	broad.mit.edu	37	2	211502472	211502472	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:211502472T>A	uc002vee.3	+	22	2866	c.2734T>A	c.(2734-2736)TTC>ATC	p.F912I	CPS1_uc010fur.2_Missense_Mutation_p.F918I|CPS1_uc010fus.2_Missense_Mutation_p.F461I	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	912				F -> L (in Ref. 6; CAE45707).	carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)														---	---	---	---
ERBB4	2066	broad.mit.edu	37	2	212989574	212989574	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:212989574T>C	uc002veg.1	-	2	235	c.137A>G	c.(136-138)TAC>TGC	p.Y46C	ERBB4_uc002veh.1_Missense_Mutation_p.Y46C|ERBB4_uc010zji.1_Missense_Mutation_p.Y46C|ERBB4_uc010zjj.1_Missense_Mutation_p.Y46C|ERBB4_uc010fut.1_Missense_Mutation_p.Y46C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	46	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)											TSP Lung(8;0.080)			---	---	---	---
ERBB4	2066	broad.mit.edu	37	2	212989624	212989624	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:212989624A>G	uc002veg.1	-	2	185	c.87T>C	c.(85-87)TGT>TGC	p.C29C	ERBB4_uc002veh.1_Silent_p.C29C|ERBB4_uc010zji.1_Silent_p.C29C|ERBB4_uc010zjj.1_Silent_p.C29C|ERBB4_uc010fut.1_Silent_p.C29C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	29	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)											TSP Lung(8;0.080)			---	---	---	---
VWC2L	402117	broad.mit.edu	37	2	215440456	215440456	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215440456A>G	uc002vet.2	+	4	711	c.581A>G	c.(580-582)GAA>GGA	p.E194G	VWC2L_uc010zjl.1_3'UTR	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	194						extracellular region					0																		---	---	---	---
ABCA12	26154	broad.mit.edu	37	2	215813766	215813766	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215813766G>A	uc002vew.2	-	46	7180	c.6960C>T	c.(6958-6960)ACC>ACT	p.T2320T	ABCA12_uc002vev.2_Silent_p.T2002T|ABCA12_uc010zjn.1_Silent_p.T1247T	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2320	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)														---	---	---	---
FN1	2335	broad.mit.edu	37	2	216240093	216240093	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216240093G>A	uc002vfa.2	-	38	6267	c.6001C>T	c.(6001-6003)CGT>TGT	p.R2001C	FN1_uc002vfb.2_Missense_Mutation_p.R1820C|FN1_uc002vfc.2_Missense_Mutation_p.R1820C|FN1_uc002vfd.2_Missense_Mutation_p.R2001C|FN1_uc002vfe.2_Missense_Mutation_p.R1910C|FN1_uc002vff.2_Missense_Mutation_p.R1910C|FN1_uc002vfg.2_Missense_Mutation_p.R1820C|FN1_uc002vfh.2_Missense_Mutation_p.R1820C|FN1_uc002vfi.2_Missense_Mutation_p.R2001C|FN1_uc002vfj.2_Missense_Mutation_p.R1911C|FN1_uc002vez.2_Missense_Mutation_p.R195C|FN1_uc010zjp.1_Missense_Mutation_p.R538C|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA|FN1_uc010fvc.1_Missense_Mutation_p.R363C|FN1_uc010fvd.1_Missense_Mutation_p.R92C	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1910	Binds to FBLN1.|Heparin-binding 2.|Fibronectin type-III 15.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
TNS1	7145	broad.mit.edu	37	2	218682425	218682425	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:218682425A>G	uc002vgt.2	-	24	4716	c.4318T>C	c.(4318-4320)TAC>CAC	p.Y1440H	TNS1_uc002vgr.2_Missense_Mutation_p.Y1427H|TNS1_uc002vgs.2_Missense_Mutation_p.Y1419H|TNS1_uc010zjv.1_Missense_Mutation_p.Y1419H	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1440						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)														---	---	---	---
SLC11A1	6556	broad.mit.edu	37	2	219259514	219259514	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219259514G>A	uc002vhv.2	+						SLC11A1_uc010zkc.1_Intron|SLC11A1_uc002vhu.1_Intron|SLC11A1_uc002vhw.2_Intron|SLC11A1_uc010fvr.2_Intron	NM_000578	NP_000569			natural resistance-associated macrophage protein						activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
BCS1L	617	broad.mit.edu	37	2	219526551	219526551	+	Missense_Mutation	SNP	G	A	A	rs143968821		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219526551G>A	uc002vio.2	+	4	948	c.530G>A	c.(529-531)CGT>CAT	p.R177H	ZNF142_uc002vin.2_5'Flank|ZNF142_uc010fvt.2_5'Flank|ZNF142_uc002vim.2_5'Flank|BCS1L_uc002vip.2_Missense_Mutation_p.R177H|BCS1L_uc002viq.2_Missense_Mutation_p.R177H|BCS1L_uc010fvu.2_Missense_Mutation_p.R177H|BCS1L_uc010fvv.2_Missense_Mutation_p.R177H|BCS1L_uc002vir.2_Missense_Mutation_p.R177H|BCS1L_uc002vis.2_Missense_Mutation_p.R177H	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	177	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
STK36	27148	broad.mit.edu	37	2	219554645	219554645	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219554645A>G	uc002viu.2	+	13	1890	c.1624A>G	c.(1624-1626)ACC>GCC	p.T542A	STK36_uc002viv.2_Missense_Mutation_p.T542A	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	542					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)														---	---	---	---
TTLL4	9654	broad.mit.edu	37	2	219602475	219602475	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219602475G>T	uc002viy.2	+	3	446	c.76G>T	c.(76-78)GGC>TGC	p.G26C	TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Missense_Mutation_p.G26C	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	26					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)														---	---	---	---
TTLL4	9654	broad.mit.edu	37	2	219603313	219603313	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219603313A>G	uc002viy.2	+	3	1284	c.914A>G	c.(913-915)TAT>TGT	p.Y305C	TTLL4_uc010zkl.1_Missense_Mutation_p.Y140C|TTLL4_uc010fvx.2_Missense_Mutation_p.Y305C	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	305					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)														---	---	---	---
PRKAG3	53632	broad.mit.edu	37	2	219694778	219694778	+	Missense_Mutation	SNP	G	A	A	rs141188865		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219694778G>A	uc002vjb.1	-	4	575	c.556C>T	c.(556-558)CGC>TGC	p.R186C	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Missense_Mutation_p.R186C|PRKAG3_uc010zko.1_Missense_Mutation_p.R182C	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	186					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
WNT10A	80326	broad.mit.edu	37	2	219746929	219746929	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219746929G>A	uc002vjd.1	+	2	623	c.160G>A	c.(160-162)GTG>ATG	p.V54M		NM_025216	NP_079492	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family,	54					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
NHEJ1	79840	broad.mit.edu	37	2	219942915	219942915	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219942915G>A	uc002vjp.3	-	6	748	c.602C>T	c.(601-603)GCA>GTA	p.A201V	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	201					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)									Direct_reversal_of_damage|NHEJ					---	---	---	---
ABCB6	10058	broad.mit.edu	37	2	220075831	220075831	+	Splice_Site	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220075831C>A	uc002vkc.1	-	15	2246	c.1969_splice	c.e15-1	p.V657_splice	ABCB6_uc010fwe.1_Splice_Site_p.V611_splice	NM_005689	NP_005680			ATP-binding cassette, sub-family B, member 6						cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
ABCB6	10058	broad.mit.edu	37	2	220080754	220080754	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220080754C>T	uc002vkc.1	-	5	1396	c.1119G>A	c.(1117-1119)GCG>GCA	p.A373A	ABCB6_uc010fwe.1_Silent_p.A327A|ABCB6_uc010zku.1_Intron	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	373	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220309422	220309422	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220309422C>T	uc010fwg.2	+	2	436	c.436C>T	c.(436-438)CGC>TGC	p.R146C	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	146					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220333749	220333749	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220333749G>A	uc010fwg.2	+	12	3470	c.3470G>A	c.(3469-3471)CGG>CAG	p.R1157Q		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1157					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220416496	220416496	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220416496T>C	uc010fwk.2	-	20	5495	c.5438A>G	c.(5437-5439)CAC>CGC	p.H1813R	hsa-mir-3132|MI0014152_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	1813	Ig-like 14.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220428124	220428124	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220428124T>C	uc010fwk.2	-	7	2690	c.2633A>G	c.(2632-2634)CAG>CGG	p.Q878R	OBSL1_uc010zli.1_5'Flank|OBSL1_uc010fwl.1_Missense_Mutation_p.Q353R|OBSL1_uc002vmi.2_Missense_Mutation_p.Q878R|OBSL1_uc002vmj.2_Missense_Mutation_p.Q465R	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	878	Ig-like 6.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)														---	---	---	---
OBSL1	23363	broad.mit.edu	37	2	220431818	220431818	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220431818T>G	uc010fwk.2	-	5	1925	c.1868A>C	c.(1867-1869)GAG>GCG	p.E623A	OBSL1_uc010fwl.1_Missense_Mutation_p.E98A|OBSL1_uc002vmi.2_Missense_Mutation_p.E623A|OBSL1_uc002vmj.2_Missense_Mutation_p.E210A	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	623					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)														---	---	---	---
STK11IP	114790	broad.mit.edu	37	2	220476719	220476719	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220476719G>A	uc002vml.2	+	19	2454	c.2411G>A	c.(2410-2412)CGG>CAG	p.R804Q		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	804					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
SLC4A3	6508	broad.mit.edu	37	2	220502890	220502890	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220502890G>A	uc002vmp.3	+	18	3040	c.2771G>A	c.(2770-2772)CGT>CAT	p.R924H	SLC4A3_uc002vmo.3_Missense_Mutation_p.R951H|SLC4A3_uc010fwm.2_Missense_Mutation_p.R474H	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	924	Cytoplasmic (Potential).|Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
SLC4A3	6508	broad.mit.edu	37	2	220503505	220503505	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220503505T>C	uc002vmp.3	+	19	3206	c.2937T>C	c.(2935-2937)CGT>CGC	p.R979R	SLC4A3_uc002vmo.3_Silent_p.R1006R|SLC4A3_uc010fwm.2_Silent_p.R529R	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	979	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
EPHA4	2043	broad.mit.edu	37	2	222298873	222298873	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:222298873A>G	uc002vmq.2	-	14	2527	c.2485T>C	c.(2485-2487)TCC>CCC	p.S829P	EPHA4_uc002vmr.2_Missense_Mutation_p.S829P|EPHA4_uc010zlm.1_Missense_Mutation_p.S770P|EPHA4_uc010zln.1_Missense_Mutation_p.S829P	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	829	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)														---	---	---	---
WDFY1	57590	broad.mit.edu	37	2	224763705	224763705	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:224763705A>G	uc002vnq.2	-	6	619	c.568T>C	c.(568-570)TCA>CCA	p.S190P		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	190	WD 4.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)														---	---	---	---
CUL3	8452	broad.mit.edu	37	2	225371566	225371566	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225371566T>C	uc002vny.2	-						CUL3_uc010zls.1_Intron|CUL3_uc010fwy.1_Intron	NM_003590	NP_003581			cullin 3						cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)														---	---	---	---
DOCK10	55619	broad.mit.edu	37	2	225740890	225740890	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:225740890T>C	uc010fwz.1	-	8	1035	c.796A>G	c.(796-798)ACC>GCC	p.T266A	DOCK10_uc002vob.2_Missense_Mutation_p.T260A|DOCK10_uc002vod.1_Missense_Mutation_p.T266A	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	266	PH.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)														---	---	---	---
COL4A3	1285	broad.mit.edu	37	2	228121099	228121099	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228121099A>G	uc002vom.1	+	17	1136	c.974A>G	c.(973-975)GAA>GGA	p.E325G	COL4A3_uc002von.1_Missense_Mutation_p.E325G|COL4A3_uc002voo.1_Missense_Mutation_p.E325G|COL4A3_uc002vop.1_Missense_Mutation_p.E325G|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	325	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)														---	---	---	---
COL4A3	1285	broad.mit.edu	37	2	228142273	228142273	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228142273A>G	uc002vom.1	+						COL4A3_uc002von.1_Intron|COL4A3_uc002voo.1_Intron|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082			alpha 3 type IV collagen isoform 1 precursor						activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)														---	---	---	---
SLC19A3	80704	broad.mit.edu	37	2	228552887	228552887	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228552887T>A	uc002vpi.2	-	5	1398	c.1309A>T	c.(1309-1311)ATT>TTT	p.I437F	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.I433F	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	437	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)													---	---	---	---
SLC19A3	80704	broad.mit.edu	37	2	228563875	228563875	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228563875A>G	uc002vpi.2	-	3	645	c.556T>C	c.(556-558)TTC>CTC	p.F186L	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.F182L	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	186	Helical; (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)													---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230683187	230683187	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230683187C>T	uc002vpw.1	-	8	1457	c.1348G>A	c.(1348-1350)GAT>AAT	p.D450N	TRIP12_uc002vpx.1_Missense_Mutation_p.D498N|TRIP12_uc002vpy.1_Missense_Mutation_p.D153N|TRIP12_uc010zlz.1_Intron|TRIP12_uc010fxh.1_Missense_Mutation_p.D456N	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	450					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230723955	230723955	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230723955C>T	uc002vpw.1	-	3	543	c.434G>A	c.(433-435)CGG>CAG	p.R145Q	TRIP12_uc002vpx.1_Missense_Mutation_p.R187Q|TRIP12_uc002vpy.1_Intron|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Missense_Mutation_p.R145Q	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	145					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
SP140L	93349	broad.mit.edu	37	2	231254679	231254679	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231254679T>C	uc010fxm.1	+	11	996	c.905T>C	c.(904-906)TTA>TCA	p.L302S	SP140L_uc010fxo.1_Intron	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	302	SAND.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1																		---	---	---	---
SP100	6672	broad.mit.edu	37	2	231331847	231331847	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231331847A>G	uc002vqt.2	+	13	1349	c.1208A>G	c.(1207-1209)GAC>GGC	p.D403G	SP100_uc002vqs.2_Missense_Mutation_p.D403G|SP100_uc002vqu.1_Missense_Mutation_p.D403G|SP100_uc002vqq.1_Missense_Mutation_p.D403G|SP100_uc002vqr.1_Missense_Mutation_p.D378G|SP100_uc010zmc.1_Missense_Mutation_p.D378G|SP100_uc002vqv.1_Missense_Mutation_p.D367G	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	403					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)														---	---	---	---
PSMD1	5707	broad.mit.edu	37	2	231941799	231941799	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231941799G>A	uc002vrn.1	+	9	1125	c.994G>A	c.(994-996)GAA>AAA	p.E332K	PSMD1_uc002vrm.1_Missense_Mutation_p.E332K|PSMD1_uc010fxu.1_Missense_Mutation_p.E196K	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	332					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)													---	---	---	---
HTR2B	3357	broad.mit.edu	37	2	231973323	231973323	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231973323T>C	uc002vro.2	-	4	1859	c.1354A>G	c.(1354-1356)ACC>GCC	p.T452A	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Missense_Mutation_p.T385A	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	452	Cytoplasmic (By similarity).			T -> P (in Ref. 2; CAA85319).	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)													---	---	---	---
HTR2B	3357	broad.mit.edu	37	2	231973661	231973661	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231973661G>T	uc002vro.2	-	4	1521	c.1016C>A	c.(1015-1017)CCC>CAC	p.P339H	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Missense_Mutation_p.P272H	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	339	Helical; Name=6; (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)													---	---	---	---
CHRNG	1146	broad.mit.edu	37	2	233404843	233404843	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233404843T>C	uc002vsx.1	+	2	216	c.195_splice	c.e2+2	p.L65_splice	CHRNG_uc010fyd.2_Splice_Site_p.L65_splice|CHRNG_uc010fye.1_Splice_Site_p.L65_splice	NM_005199	NP_005190			cholinergic receptor, nicotinic, gamma						muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)														---	---	---	---
EFHD1	80303	broad.mit.edu	37	2	233527579	233527579	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233527579G>C	uc002vtc.2	+	2	578	c.370G>C	c.(370-372)GCC>CCC	p.A124P	EFHD1_uc010fyf.2_Missense_Mutation_p.A28P|EFHD1_uc002vtd.2_Missense_Mutation_p.A12P	NM_025202	NP_079478	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	124	EF-hand 1.						calcium ion binding|protein binding				0		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)														---	---	---	---
GIGYF2	26058	broad.mit.edu	37	2	233620987	233620987	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233620987G>C	uc002vti.3	+	8	659	c.322G>C	c.(322-324)GGA>CGA	p.G108R	GIGYF2_uc010zmj.1_Missense_Mutation_p.G108R|GIGYF2_uc002vtg.2_Missense_Mutation_p.G108R|GIGYF2_uc002vtj.3_Missense_Mutation_p.G108R|GIGYF2_uc002vtk.3_Missense_Mutation_p.G108R|GIGYF2_uc002vth.3_Missense_Mutation_p.G108R|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	108	Poly-Gly.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)														---	---	---	---
NEU2	4759	broad.mit.edu	37	2	233897415	233897415	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233897415G>A	uc010zmn.1	+	1	34	c.34G>A	c.(34-36)GTG>ATG	p.V12M		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	12							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)														---	---	---	---
AGAP1	116987	broad.mit.edu	37	2	236649676	236649676	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:236649676G>C	uc002vvs.2	+	4	975	c.380G>C	c.(379-381)GGC>GCC	p.G127A	AGAP1_uc002vvt.2_Missense_Mutation_p.G127A	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	127	Small GTPase-like.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238257297	238257297	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238257297C>T	uc002vwl.2	-	29	7174	c.6889G>A	c.(6889-6891)GGG>AGG	p.G2297R	COL6A3_uc002vwo.2_Missense_Mutation_p.G2091R|COL6A3_uc010znj.1_Missense_Mutation_p.G1690R|COL6A3_uc002vwp.1_Missense_Mutation_p.G118R	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2297	Triple-helical region.|Collagen-like 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238287506	238287506	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238287506T>A	uc002vwl.2	-	6	2555	c.2270A>T	c.(2269-2271)GAC>GTC	p.D757V	COL6A3_uc002vwo.2_Missense_Mutation_p.D551V|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Missense_Mutation_p.D551V|COL6A3_uc002vwr.2_Missense_Mutation_p.D350V|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	757	VWFA 4.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238303834	238303834	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238303834A>G	uc002vwl.2	-	3	390	c.105T>C	c.(103-105)GGT>GGC	p.G35G	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Silent_p.G35G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	35	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
RBM44	375316	broad.mit.edu	37	2	238725821	238725821	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238725821A>G	uc002vxi.3	+	3	394	c.262A>G	c.(262-264)ACT>GCT	p.T88A		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	87							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)														---	---	---	---
UBE2F	140739	broad.mit.edu	37	2	238925217	238925217	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238925217A>G	uc002vxk.2	+	5	315	c.224A>G	c.(223-225)TAC>TGC	p.Y75C	UBE2F_uc010znn.1_Missense_Mutation_p.Y43C|UBE2F_uc002vxl.2_RNA|UBE2F_uc010zno.1_Intron|UBE2F_uc010znp.1_Missense_Mutation_p.Y75C|SCLY_uc002vxm.3_Intron	NM_080678	NP_542409	Q969M7	UBE2F_HUMAN	NEDD8-conjugating enzyme	75					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding				0		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)														---	---	---	---
SCLY	51540	broad.mit.edu	37	2	238990408	238990408	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238990408C>T	uc010fyv.2	+	5	607	c.543C>T	c.(541-543)CTC>CTT	p.L181L	SCLY_uc002vxm.3_Silent_p.L148L|SCLY_uc002vxn.2_Silent_p.L181L|SCLY_uc010znq.1_Intron|SCLY_uc010znr.1_Silent_p.L87L	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	181					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239181712	239181712	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239181712G>A	uc002vyc.2	-	5	806	c.569C>T	c.(568-570)GCC>GTC	p.A190V	PER2_uc010znv.1_Missense_Mutation_p.A190V|PER2_uc010znw.1_Missense_Mutation_p.A190V|PER2_uc010fyx.1_Missense_Mutation_p.A190V	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	190	PAS 1.				circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
GPC1	2817	broad.mit.edu	37	2	241404053	241404053	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241404053G>A	uc002vyw.3	+	5	1125	c.904G>A	c.(904-906)GAC>AAC	p.D302N		NM_002081	NP_002072	P35052	GPC1_HUMAN	glypican 1 precursor	302					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)														---	---	---	---
ANKMY1	51281	broad.mit.edu	37	2	241465157	241465157	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241465157T>C	uc002vyz.1	-	6	1242	c.1013A>G	c.(1012-1014)TAC>TGC	p.Y338C	ANKMY1_uc002vza.1_Missense_Mutation_p.Y197C|ANKMY1_uc010fzd.1_Missense_Mutation_p.Y427C|ANKMY1_uc002vzb.1_Missense_Mutation_p.Y197C|ANKMY1_uc002vzc.1_Missense_Mutation_p.Y197C|ANKMY1_uc002vzd.1_Missense_Mutation_p.Y197C|ANKMY1_uc010fze.1_Missense_Mutation_p.Y7C|ANKMY1_uc002vze.2_Missense_Mutation_p.Y99C	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	338							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)														---	---	---	---
SNED1	25992	broad.mit.edu	37	2	242027820	242027820	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242027820A>G	uc002wah.1	+						SNED1_uc002waj.1_Intron	NM_001080437	NP_001073906			6720455I24Rik homolog precursor						cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)														---	---	---	---
PPP1R7	5510	broad.mit.edu	37	2	242097285	242097285	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242097285C>T	uc002wat.1	+						PPP1R7_uc010fzm.1_Intron|PPP1R7_uc002war.2_Intron|PPP1R7_uc002was.2_Intron|PPP1R7_uc002wau.1_Intron|PPP1R7_uc002wav.1_Intron	NM_002712	NP_002703			protein phosphatase 1, regulatory subunit 7							cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)														---	---	---	---
HDLBP	3069	broad.mit.edu	37	2	242181959	242181959	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242181959T>C	uc002waz.2	-	17	2313	c.2085A>G	c.(2083-2085)TCA>TCG	p.S695S	HDLBP_uc002wba.2_Silent_p.S695S|HDLBP_uc002wbb.2_Silent_p.S647S	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	695	KH 8.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)														---	---	---	---
FARP2	9855	broad.mit.edu	37	2	242432345	242432345	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242432345A>G	uc002wbi.1	+	25	2906	c.2789A>G	c.(2788-2790)AAC>AGC	p.N930S		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	930	PH 2.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)														---	---	---	---
ATG4B	23192	broad.mit.edu	37	2	242594764	242594764	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242594764T>C	uc002wbv.2	+						ATG4B_uc002wbu.2_Intron|ATG4B_uc002wbw.2_Intron|ATG4B_uc010zox.1_Intron|ATG4B_uc010zoy.1_Intron|ATG4B_uc010fzp.2_Intron|ATG4B_uc010zoz.1_Intron	NM_013325	NP_037457			APG4 autophagy 4 homolog B isoform a						autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)														---	---	---	---
ING5	84289	broad.mit.edu	37	2	242644110	242644110	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242644110T>A	uc002wcd.2	+	2	105	c.80T>A	c.(79-81)CTG>CAG	p.L27Q	ING5_uc002wcc.1_Missense_Mutation_p.L27Q	NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	27					DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)														---	---	---	---
ING5	84289	broad.mit.edu	37	2	242662478	242662478	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242662478G>A	uc002wcd.2	+	6	632	c.607G>A	c.(607-609)GAC>AAC	p.D203N		NM_032329	NP_115705	Q8WYH8	ING5_HUMAN	inhibitor of growth family, member 5	203	PHD-type.				DNA replication|histone H3 acetylation|negative regulation of cell proliferation|negative regulation of growth|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-33)|all cancers(36;4.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)														---	---	---	---
C2orf85	285093	broad.mit.edu	37	2	242812071	242812071	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242812071G>A	uc010fzu.1	+							NM_173821	NP_776182			hypothetical protein LOC285093							integral to membrane				ovary(1)	1																		---	---	---	---
C2orf85	285093	broad.mit.edu	37	2	242813886	242813886	+	Missense_Mutation	SNP	C	A	A	rs76064495	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242813886C>A	uc010fzu.1	+	2	202	c.179C>A	c.(178-180)CCG>CAG	p.P60Q		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	60						integral to membrane				ovary(1)	1																		---	---	---	---
CHL1	10752	broad.mit.edu	37	3	431057	431057	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:431057G>A	uc003bou.2	+	19	2593	c.2322G>A	c.(2320-2322)ACG>ACA	p.T774T	CHL1_uc003bot.2_Silent_p.T790T|CHL1_uc003bow.1_Silent_p.T774T|CHL1_uc011asi.1_Silent_p.T790T	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	774	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)														---	---	---	---
CNTN6	27255	broad.mit.edu	37	3	1414032	1414032	+	Silent	SNP	C	T	T	rs138661122		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:1414032C>T	uc003boz.2	+	13	1809	c.1542C>T	c.(1540-1542)GGC>GGT	p.G514G	CNTN6_uc011asj.1_Silent_p.G442G|CNTN6_uc003bpa.2_Silent_p.G514G	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	514	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)														---	---	---	---
LRRN1	57633	broad.mit.edu	37	3	3886572	3886572	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:3886572A>G	uc003bpt.3	+	2	1008	c.247A>G	c.(247-249)AAC>GAC	p.N83D	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	83	Extracellular (Potential).|LRR 1.					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)														---	---	---	---
C3orf32	51066	broad.mit.edu	37	3	8671348	8671348	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:8671348A>G	uc003bqu.2	-	7	768	c.522_splice	c.e7+1	p.T174_splice	C3orf32_uc003bqz.2_Splice_Site_p.T174_splice|C3orf32_uc003bqt.2_Splice_Site_p.T123_splice|C3orf32_uc011atg.1_Splice_Site_p.T196_splice|C3orf32_uc003bqv.2_Splice_Site_p.T123_splice|C3orf32_uc003bqw.2_Splice_Site|C3orf32_uc003bqx.2_Splice_Site|C3orf32_uc003bqy.2_Splice_Site_p.T174_splice	NM_015931	NP_057015			hypothetical protein LOC51066											skin(1)	1																		---	---	---	---
THUMPD3	25917	broad.mit.edu	37	3	9413199	9413199	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9413199C>T	uc003bro.3	+	4	934	c.786C>T	c.(784-786)GAC>GAT	p.D262D	LOC440944_uc003brm.2_Intron|THUMPD3_uc003brn.3_Silent_p.D262D	NM_001114092	NP_001107564	Q9BV44	THUM3_HUMAN	THUMP domain containing 3	262	THUMP.						methyltransferase activity|protein binding|RNA binding			ovary(1)	1	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.101)														---	---	---	---
SETD5	55209	broad.mit.edu	37	3	9488951	9488951	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9488951A>C	uc003brt.2	+	14	2177	c.1742A>C	c.(1741-1743)CAG>CCG	p.Q581P	SETD5_uc003brs.1_Missense_Mutation_p.Q562P|SETD5_uc003bru.2_Missense_Mutation_p.Q483P|SETD5_uc003brv.2_Missense_Mutation_p.Q470P|SETD5_uc010hck.2_Missense_Mutation_p.Q63P|SETD5_uc003brx.2_Missense_Mutation_p.Q250P	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	581										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)														---	---	---	---
CPNE9	151835	broad.mit.edu	37	3	9768398	9768398	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9768398T>C	uc003bsd.2	+	18	1565	c.1394T>C	c.(1393-1395)ATG>ACG	p.M465T		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	465	VWFA.									ovary(2)	2	Medulloblastoma(99;0.227)																	---	---	---	---
BRPF1	7862	broad.mit.edu	37	3	9775910	9775910	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9775910G>A	uc003bse.2	+	2	485	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	BRPF1_uc003bsf.2_Missense_Mutation_p.R29Q|BRPF1_uc003bsg.2_Missense_Mutation_p.R29Q|BRPF1_uc011ati.1_Missense_Mutation_p.R29Q	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	29	C2H2-type.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)																	---	---	---	---
OGG1	4968	broad.mit.edu	37	3	9792665	9792665	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9792665A>G	uc003bsi.2	+	2	517	c.174A>G	c.(172-174)GTA>GTG	p.V58V	OGG1_uc003bsh.2_Silent_p.V58V|OGG1_uc003bsj.2_Silent_p.V58V|OGG1_uc003bsk.2_Silent_p.V58V|OGG1_uc003bsl.2_Silent_p.V58V|OGG1_uc003bsm.2_Silent_p.V58V|OGG1_uc003bsn.2_Silent_p.V58V|OGG1_uc003bso.2_Silent_p.V58V|OGG1_uc003bsp.1_5'Flank|OGG1_uc010hcm.1_5'Flank|OGG1_uc003bsq.1_5'Flank|OGG1_uc003bsr.1_5'Flank	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	58					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)												BER_DNA_glycosylases					---	---	---	---
ARPC4	10093	broad.mit.edu	37	3	9841903	9841903	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9841903A>G	uc003bsz.1	+	3	736	c.157A>G	c.(157-159)ATC>GTC	p.I53V	ARPC4_uc003bta.1_5'UTR|ARPC4_uc003btb.1_5'UTR|ARPC4_uc003btc.1_5'UTR|TTLL3_uc003btd.3_5'UTR	NM_005718	NP_005709	P59998	ARPC4_HUMAN	actin related protein 2/3 complex subunit 4	53					actin filament polymerization|actin nucleation	Arp2/3 protein complex|cell projection|cytoplasm	actin binding				0	Medulloblastoma(99;0.227)																	---	---	---	---
CRELD1	78987	broad.mit.edu	37	3	9982597	9982597	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9982597G>A	uc003bug.2	+	6	642	c.524G>A	c.(523-525)CGA>CAA	p.R175Q	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Missense_Mutation_p.R175Q|CRELD1_uc003buh.2_Missense_Mutation_p.R175Q|CRELD1_uc003bui.2_Missense_Mutation_p.R175Q|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	175	Extracellular (Potential).|EGF-like 1.				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1																		---	---	---	---
IRAK2	3656	broad.mit.edu	37	3	10264468	10264468	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10264468C>T	uc003bve.1	+	9	1238	c.1162C>T	c.(1162-1164)CGG>TGG	p.R388W		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	388	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8																		---	---	---	---
SLC6A11	6538	broad.mit.edu	37	3	10916650	10916650	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10916650T>C	uc003bvz.2	+	6	795	c.761T>C	c.(760-762)GTA>GCA	p.V254A		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	254	Helical; Name=5; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)														---	---	---	---
SLC6A1	6529	broad.mit.edu	37	3	11078588	11078588	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11078588G>A	uc010hdq.2	+	16	2147	c.1736G>A	c.(1735-1737)CGC>CAC	p.R579H		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	579	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)													---	---	---	---
SYN2	6854	broad.mit.edu	37	3	12208796	12208796	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12208796C>T	uc003bwm.2	+	12	1207	c.1043C>T	c.(1042-1044)GCC>GTC	p.A348V	SYN2_uc003bwl.1_Missense_Mutation_p.A348V|SYN2_uc003bwn.2_Missense_Mutation_p.A22V	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	348					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NUP210	23225	broad.mit.edu	37	3	13372109	13372109	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:13372109G>A	uc003bxv.1	-	30	4044	c.3961C>T	c.(3961-3963)CGC>TGC	p.R1321C		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1321	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)																	---	---	---	---
FBLN2	2199	broad.mit.edu	37	3	13670760	13670760	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:13670760T>C	uc011avb.1	+	12	2794	c.2669T>C	c.(2668-2670)TTT>TCT	p.F890S	FBLN2_uc011auz.1_Missense_Mutation_p.F916S|FBLN2_uc011ava.1_Missense_Mutation_p.F937S|FBLN2_uc011avc.1_Missense_Mutation_p.F937S	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	890	EGF-like 6; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)															---	---	---	---
WNT7A	7476	broad.mit.edu	37	3	13896052	13896052	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:13896052G>A	uc003bye.1	-	3	852	c.547C>T	c.(547-549)CAC>TAC	p.H183Y		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	183					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3																		---	---	---	---
C3orf20	84077	broad.mit.edu	37	3	14768513	14768513	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14768513T>C	uc003byy.2	+	11	2076	c.1672T>C	c.(1672-1674)TCT>CCT	p.S558P	C3orf20_uc003byz.2_Missense_Mutation_p.S436P|C3orf20_uc003bza.2_Missense_Mutation_p.S436P|C3orf20_uc003bzb.1_Missense_Mutation_p.S59P	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	558						cytoplasm|integral to membrane				ovary(3)|skin(1)	4																		---	---	---	---
MRPS25	64432	broad.mit.edu	37	3	15094962	15094962	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15094962T>C	uc003bzl.2	-	3	369	c.254A>G	c.(253-255)CAG>CGG	p.Q85R	MRPS25_uc011avl.1_Intron|MRPS25_uc011avm.1_Missense_Mutation_p.Q85R	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	85					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0																		---	---	---	---
ZFYVE20	64145	broad.mit.edu	37	3	15116352	15116352	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15116352C>T	uc003bzm.1	-	14	1906	c.1292G>A	c.(1291-1293)CGC>CAC	p.R431H	ZFYVE20_uc010hek.1_Missense_Mutation_p.R431H	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	431	Necessary for the interaction with RAB4A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2																		---	---	---	---
ZFYVE20	64145	broad.mit.edu	37	3	15131914	15131914	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15131914T>C	uc003bzm.1	-	5	895	c.281A>G	c.(280-282)CAG>CGG	p.Q94R	ZFYVE20_uc010hek.1_Missense_Mutation_p.Q94R|ZFYVE20_uc011avn.1_Missense_Mutation_p.Q94R	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	94					blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2																		---	---	---	---
HACL1	26061	broad.mit.edu	37	3	15604967	15604967	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15604967T>C	uc003caf.2	-	16	1762	c.1602A>G	c.(1600-1602)ACA>ACG	p.T534T	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Silent_p.T507T|HACL1_uc011avt.1_Silent_p.T474T|HACL1_uc003cag.2_Silent_p.T178T|HACL1_uc011avu.1_Silent_p.T452T|HACL1_uc010hep.2_Silent_p.T293T	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	534					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0																		---	---	---	---
HACL1	26061	broad.mit.edu	37	3	15609957	15609957	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15609957T>C	uc003caf.2	-	13	1392	c.1232A>G	c.(1231-1233)AAC>AGC	p.N411S	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Missense_Mutation_p.N384S|HACL1_uc011avt.1_Missense_Mutation_p.N351S|HACL1_uc003cag.2_Missense_Mutation_p.N55S|HACL1_uc011avu.1_Missense_Mutation_p.N329S|HACL1_uc010hep.2_Missense_Mutation_p.N170S	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	411	Thiamine pyrophosphate binding.				fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0																		---	---	---	---
HACL1	26061	broad.mit.edu	37	3	15610025	15610025	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15610025T>C	uc003caf.2	-	13	1324	c.1164A>G	c.(1162-1164)CTA>CTG	p.L388L	HACL1_uc011avr.1_RNA|HACL1_uc011avs.1_Silent_p.L361L|HACL1_uc011avt.1_Silent_p.L328L|HACL1_uc003cag.2_Silent_p.L32L|HACL1_uc011avu.1_Silent_p.L306L|HACL1_uc010hep.2_Silent_p.L147L	NM_012260	NP_036392	Q9UJ83	HACL1_HUMAN	2-hydroxyphytanoyl-CoA lyase	388					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding				0																		---	---	---	---
ANKRD28	23243	broad.mit.edu	37	3	15726863	15726863	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15726863T>C	uc003caj.1	-	21	2312	c.2169A>G	c.(2167-2169)ATA>ATG	p.I723M	ANKRD28_uc003cai.1_Missense_Mutation_p.I569M|ANKRD28_uc011avz.1_Missense_Mutation_p.I569M|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.I753M|ANKRD28_uc003cam.2_Missense_Mutation_p.I756M	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	723	ANK 21.					nucleoplasm	protein binding			breast(1)	1																		---	---	---	---
SATB1	6304	broad.mit.edu	37	3	18428081	18428081	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:18428081C>T	uc003cbh.2	-	8	2964	c.1229G>A	c.(1228-1230)CGA>CAA	p.R410Q	SATB1_uc003cbi.2_Missense_Mutation_p.R410Q|SATB1_uc003cbj.2_Missense_Mutation_p.R410Q	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	410	CUT 1.|Matrix attachment region (MAR) DNA- binding.			R->N: Impaired MAR-DNA-binding.	cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4																		---	---	---	---
SATB1	6304	broad.mit.edu	37	3	18462397	18462397	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:18462397A>G	uc003cbh.2	-	2	1798	c.63T>C	c.(61-63)AGT>AGC	p.S21S	SATB1_uc003cbi.2_Silent_p.S21S|SATB1_uc003cbj.2_Silent_p.S21S	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	21	Nuclear localization signal.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4																		---	---	---	---
SGOL1	151648	broad.mit.edu	37	3	20225109	20225109	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20225109T>C	uc003cbs.2	-	3	517	c.330A>G	c.(328-330)GAA>GAG	p.E110E	SGOL1_uc003cbr.2_Silent_p.E110E|SGOL1_uc010hfa.2_Silent_p.E110E|SGOL1_uc003cbt.2_Silent_p.E110E|SGOL1_uc003cbu.2_Silent_p.E110E|SGOL1_uc003cbv.2_Silent_p.E110E|SGOL1_uc003cbw.2_Silent_p.E110E|SGOL1_uc003cbx.2_Silent_p.E110E|SGOL1_uc003cby.2_Silent_p.E110E|SGOL1_uc003cbz.2_Silent_p.E110E|SGOL1_uc003cca.2_Silent_p.E110E|SGOL1_uc003ccb.2_Silent_p.E110E|SGOL1_uc003ccc.2_Silent_p.E110E	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	110	Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0																		---	---	---	---
SLC4A7	9497	broad.mit.edu	37	3	27490198	27490198	+	Missense_Mutation	SNP	C	T	T	rs149158126		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27490198C>T	uc003cdv.2	-	3	277	c.206G>A	c.(205-207)CGG>CAG	p.R69Q	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.R74Q|SLC4A7_uc011aww.1_Missense_Mutation_p.R78Q|SLC4A7_uc011awx.1_Missense_Mutation_p.R78Q|SLC4A7_uc011awy.1_Missense_Mutation_p.R74Q|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.R74Q|SLC4A7_uc011axb.1_Missense_Mutation_p.R78Q|SLC4A7_uc010hfm.2_Missense_Mutation_p.R74Q|SLC4A7_uc003cdw.2_Missense_Mutation_p.R69Q	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	69	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
EOMES	8320	broad.mit.edu	37	3	27758600	27758600	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27758600T>C	uc003cdx.2	-	6	2022	c.2022A>G	c.(2020-2022)AAA>AAG	p.K674K	EOMES_uc003cdy.3_Silent_p.K693K|EOMES_uc010hfn.2_3'UTR|EOMES_uc011axc.1_Silent_p.K398K	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	674	Required for transcription activation (By similarity).				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4																		---	---	---	---
OSBPL10	114884	broad.mit.edu	37	3	31725576	31725576	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:31725576G>A	uc003cev.2	-	9	1657	c.1276C>T	c.(1276-1278)CGA>TGA	p.R426*	OSBPL10_uc003ceu.1_Nonsense_Mutation_p.R183*|OSBPL10_uc011axf.1_Nonsense_Mutation_p.R362*	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	426					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)														---	---	---	---
GPD1L	23171	broad.mit.edu	37	3	32201136	32201136	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32201136G>A	uc003cew.2	+	7	989	c.929G>A	c.(928-930)CGC>CAC	p.R310H		NM_015141	NP_055956	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	310					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity				0																		---	---	---	---
TMPPE	643853	broad.mit.edu	37	3	33135378	33135378	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33135378A>G	uc003cfk.2	-	2	501	c.310T>C	c.(310-312)TTC>CTC	p.F104L	GLB1_uc003cfh.1_Intron|GLB1_uc003cfi.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron|TMPPE_uc011axl.1_Intron	NM_001039770	NP_001034859	Q6ZT21	TMPPE_HUMAN	transmembrane protein with	104	Helical; (Potential).					integral to membrane	metal ion binding				0																		---	---	---	---
ARPP21	10777	broad.mit.edu	37	3	35731623	35731623	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:35731623C>T	uc003cgb.2	+	8	800	c.536C>T	c.(535-537)GCT>GTT	p.A179V	ARPP21_uc003cga.2_Missense_Mutation_p.A179V|ARPP21_uc011axy.1_Missense_Mutation_p.A179V|ARPP21_uc003cgf.2_Missense_Mutation_p.A15V	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	179	R3H.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3																		---	---	---	---
ARPP21	10777	broad.mit.edu	37	3	35732357	35732357	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:35732357T>C	uc003cgb.2	+	9	810	c.546T>C	c.(544-546)AAT>AAC	p.N182N	ARPP21_uc003cga.2_Silent_p.N182N|ARPP21_uc011axy.1_Silent_p.N182N|ARPP21_uc003cgf.2_Silent_p.N18N	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	182	R3H.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3																		---	---	---	---
ARPP21	10777	broad.mit.edu	37	3	35756944	35756944	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:35756944A>G	uc003cgb.2	+	12	1175	c.911A>G	c.(910-912)CAG>CGG	p.Q304R	ARPP21_uc003cga.2_Missense_Mutation_p.Q270R|ARPP21_uc011axy.1_Missense_Mutation_p.Q270R|ARPP21_uc003cgf.2_Missense_Mutation_p.Q106R	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	304						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3																		---	---	---	---
TRANK1	9881	broad.mit.edu	37	3	36873767	36873767	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:36873767A>T	uc003cgj.2	-	12	5827	c.5525T>A	c.(5524-5526)GTC>GAC	p.V1842D		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2392					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GOLGA4	2803	broad.mit.edu	37	3	37368264	37368264	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37368264T>C	uc003cgv.2	+	14	5191	c.4887T>C	c.(4885-4887)CTT>CTC	p.L1629L	GOLGA4_uc010hgr.1_Silent_p.L1190L|GOLGA4_uc003cgw.2_Silent_p.L1651L|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Silent_p.L1510L	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1629	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
VILL	50853	broad.mit.edu	37	3	38040934	38040934	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38040934A>G	uc003chj.2	+						VILL_uc003chl.2_Intron|VILL_uc010hgu.2_Intron	NM_015873	NP_056957			villin-like protein						actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
VILL	50853	broad.mit.edu	37	3	38043035	38043035	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38043035A>G	uc003chj.2	+	12	1557	c.1271A>G	c.(1270-1272)TAC>TGC	p.Y424C	VILL_uc003chl.2_Missense_Mutation_p.Y424C|VILL_uc010hgu.2_Missense_Mutation_p.Y254C	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	424	Gelsolin-like 4.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
DLEC1	9940	broad.mit.edu	37	3	38127756	38127756	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38127756A>G	uc003cho.1	+	9	1481	c.1460A>G	c.(1459-1461)TAC>TGC	p.Y487C	DLEC1_uc003chp.1_Missense_Mutation_p.Y487C|DLEC1_uc010hgv.1_Missense_Mutation_p.Y487C|DLEC1_uc010hgw.1_Missense_Mutation_p.Y128C|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	487					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)														---	---	---	---
OXSR1	9943	broad.mit.edu	37	3	38263180	38263180	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38263180T>C	uc003chy.2	+	6	942	c.600_splice	c.e6+2	p.Q200_splice	OXSR1_uc010hhb.2_Splice_Site_p.Q134_splice|OXSR1_uc010hha.1_Splice_Site_p.Q132_splice	NM_005109	NP_005100			oxidative-stress responsive 1						intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
OXSR1	9943	broad.mit.edu	37	3	38287645	38287645	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38287645G>A	uc003chy.2	+	13	1532	c.1190G>A	c.(1189-1191)GGG>GAG	p.G397E	OXSR1_uc010hhb.2_Missense_Mutation_p.G331E	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	397					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
SLC22A13	9390	broad.mit.edu	37	3	38316147	38316147	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38316147G>A	uc003chz.3	+	3	589	c.535G>A	c.(535-537)GGC>AGC	p.G179S	SLC22A13_uc011aym.1_Intron|SLC22A13_uc011ayn.1_Missense_Mutation_p.G179S	NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	179	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)														---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38603961	38603961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38603961C>T	uc003cio.2	-	22	4102	c.3908G>A	c.(3907-3909)CGG>CAG	p.R1303Q	SCN5A_uc003cin.2_Missense_Mutation_p.R1302Q|SCN5A_uc003cil.3_Missense_Mutation_p.R1303Q|SCN5A_uc010hhi.2_Missense_Mutation_p.R1303Q|SCN5A_uc010hhk.2_Missense_Mutation_p.R1302Q|SCN5A_uc011ayr.1_Missense_Mutation_p.R1249Q|SCN5A_uc010hhj.1_Missense_Mutation_p.R913Q	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1303	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38651221	38651221	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38651221G>A	uc003cio.2	-						SCN5A_uc003cin.2_Intron|SCN5A_uc003cil.3_Intron|SCN5A_uc010hhi.2_Intron|SCN5A_uc010hhk.2_Intron|SCN5A_uc011ayr.1_Intron	NM_198056	NP_932173			voltage-gated sodium channel type V alpha						blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
SCN10A	6336	broad.mit.edu	37	3	38748787	38748787	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38748787G>A	uc003ciq.2	-	25	4369	c.4369C>T	c.(4369-4371)CCC>TCC	p.P1457S		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1457					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)													---	---	---	---
SCN10A	6336	broad.mit.edu	37	3	38830483	38830483	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38830483A>G	uc003ciq.2	-	3	434	c.434T>C	c.(433-435)GTG>GCG	p.V145A		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	145	Helical; Name=S1 of repeat I; (Potential).|I.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)													---	---	---	---
SCN11A	11280	broad.mit.edu	37	3	38888509	38888509	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38888509A>G	uc011ays.1	-	26	5251	c.5052T>C	c.(5050-5052)GAT>GAC	p.D1684D		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1684					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)													---	---	---	---
SCN11A	11280	broad.mit.edu	37	3	38889232	38889232	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38889232A>G	uc011ays.1	-	26	4528	c.4329T>C	c.(4327-4329)AGT>AGC	p.S1443S		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1443	IV.|Helical; Name=S3 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)													---	---	---	---
WDR48	57599	broad.mit.edu	37	3	39111148	39111148	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39111148G>T	uc003cit.2	+	7	595	c.585G>T	c.(583-585)TGG>TGT	p.W195C	WDR48_uc011ayt.1_Missense_Mutation_p.W186C|WDR48_uc011ayu.1_Missense_Mutation_p.W113C|WDR48_uc011ayv.1_Intron|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	195	WD 4.				interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
RPSA	3921	broad.mit.edu	37	3	39449253	39449253	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39449253T>C	uc003cjp.2	+	2	194	c.109T>C	c.(109-111)TAC>CAC	p.Y37H	RPSA_uc003cjq.2_Missense_Mutation_p.Y37H|RPSA_uc003cjr.2_Missense_Mutation_p.Y37H|RPSA_uc003cjt.2_5'Flank|SNORA6_uc003cjs.1_5'Flank	NM_002295	NP_002286	P08865	RSSA_HUMAN	ribosomal protein SA	37					cell adhesion|endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly|rRNA export from nucleus|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleus|plasma membrane	protein binding|receptor activity|ribosome binding|structural constituent of ribosome			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)														---	---	---	---
ZNF619	285267	broad.mit.edu	37	3	40529325	40529325	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40529325A>G	uc011azb.1	+	6	1722	c.1444A>G	c.(1444-1446)ACT>GCT	p.T482A	ZNF619_uc010hhz.2_Missense_Mutation_p.T433A|ZNF619_uc003ckj.2_Missense_Mutation_p.T426A|ZNF619_uc011azc.1_Missense_Mutation_p.T442A|ZNF619_uc011azd.1_Missense_Mutation_p.T398A|ZNF619_uc011aza.1_Missense_Mutation_p.T384A	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	482					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
CTNNB1	1499	broad.mit.edu	37	3	41266486	41266486	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41266486C>T	uc010hia.1	+	5	439	c.283C>T	c.(283-285)CGA>TGA	p.R95*	CTNNB1_uc003ckp.2_Nonsense_Mutation_p.R95*|CTNNB1_uc003ckq.2_Nonsense_Mutation_p.R95*|CTNNB1_uc003ckr.2_Nonsense_Mutation_p.R95*|CTNNB1_uc011azf.1_Nonsense_Mutation_p.R88*|CTNNB1_uc011azg.1_Nonsense_Mutation_p.R23*|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	95					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.T3_A126del(2)|p.V22_L139>V(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A20_Q143del(1)|p.A5_Q143>E(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.V22_T102del(1)|p.D6_K133del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.?(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.A5_D144>D(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.D17_A126del(1)|p.A20_L148del(1)|p.E9_I140del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.A20_S111del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				---	---	---	---
TRAK1	22906	broad.mit.edu	37	3	42261039	42261039	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42261039A>G	uc003cky.2	+	15	2233	c.2017A>G	c.(2017-2019)ACC>GCC	p.T673A	TRAK1_uc011azi.1_Missense_Mutation_p.T652A	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	673					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1																		---	---	---	---
SNRK	54861	broad.mit.edu	37	3	43388884	43388884	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:43388884C>T	uc003cms.3	+	7	1465	c.1133C>T	c.(1132-1134)ACG>ATG	p.T378M	SNRK_uc003cmt.3_Missense_Mutation_p.T378M|SNRK_uc010hik.2_Missense_Mutation_p.T378M|SNRK_uc011azr.1_Missense_Mutation_p.T172M	NM_017719	NP_060189	Q9NRH2	SNRK_HUMAN	SNF related kinase	378					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)														---	---	---	---
ZNF445	353274	broad.mit.edu	37	3	44489669	44489669	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44489669G>A	uc003cnf.2	-	8	1842	c.1494C>T	c.(1492-1494)TCC>TCT	p.S498S	ZNF445_uc011azv.1_Silent_p.S486S|ZNF445_uc011azw.1_Silent_p.S498S	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	498	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)														---	---	---	---
ZNF167	55888	broad.mit.edu	37	3	44598750	44598750	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44598750G>A	uc010hin.2	+	2	599	c.211G>A	c.(211-213)GCA>ACA	p.A71T	ZNF167_uc003cnh.2_RNA|ZNF167_uc003cni.2_Missense_Mutation_p.A71T|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.A71T|ZNF167_uc003cnk.2_Missense_Mutation_p.A71T	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	71	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)														---	---	---	---
ZNF197	10168	broad.mit.edu	37	3	44683453	44683453	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44683453A>G	uc003cnm.2	+	6	1037	c.831A>G	c.(829-831)GCA>GCG	p.A277A	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	277	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)														---	---	---	---
ZNF35	7584	broad.mit.edu	37	3	44700955	44700955	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44700955G>A	uc003cnq.2	+	4	1321	c.1100G>A	c.(1099-1101)TGT>TAT	p.C367Y	ZNF35_uc003cnr.2_Missense_Mutation_p.C207Y	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	367	C2H2-type 6.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44872475	44872475	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44872475A>G	uc003cnx.3	+	26	3285	c.3136A>G	c.(3136-3138)ACC>GCC	p.T1046A	KIF15_uc010hiq.2_Missense_Mutation_p.T949A|KIF15_uc010hir.2_Missense_Mutation_p.T94A	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1046	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
ZDHHC3	51304	broad.mit.edu	37	3	45000709	45000709	+	Missense_Mutation	SNP	C	T	T	rs148007027		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45000709C>T	uc003cod.2	-	2	494	c.220G>A	c.(220-222)GTG>ATG	p.V74M	ZDHHC3_uc003cog.2_Missense_Mutation_p.V74M|ZDHHC3_uc011bad.1_Missense_Mutation_p.V74M	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	74	Helical; (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)														---	---	---	---
XCR1	2829	broad.mit.edu	37	3	46062826	46062826	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46062826T>C	uc003cpe.2	-	3	838	c.614A>G	c.(613-615)TAC>TGC	p.Y205C	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Missense_Mutation_p.Y205C	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	205	Helical; Name=5; (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)														---	---	---	---
CCR1	1230	broad.mit.edu	37	3	46245390	46245390	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46245390C>T	uc003cph.1	-	2	486	c.415G>A	c.(415-417)GTG>ATG	p.V139M	CCR3_uc003cpg.1_Intron	NM_001295	NP_001286	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	139	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			skin(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)														---	---	---	---
LTF	4057	broad.mit.edu	37	3	46480816	46480816	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46480816G>A	uc003cpq.2	-	15	1917	c.1879C>T	c.(1879-1881)CGC>TGC	p.R627C	LTF_uc003fzr.2_Missense_Mutation_p.R583C|LTF_uc010hjh.2_Missense_Mutation_p.R625C|LTF_uc003cpr.2_Missense_Mutation_p.R614C	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	627	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)													---	---	---	---
ALS2CL	259173	broad.mit.edu	37	3	46721994	46721994	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46721994G>A	uc003cqa.1	-	14	1664	c.1474C>T	c.(1474-1476)CGC>TGC	p.R492C	ALS2CL_uc003cpz.1_Missense_Mutation_p.R7C|ALS2CL_uc003cqb.1_Missense_Mutation_p.R492C|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	492	MORN 6.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)														---	---	---	---
PRSS45	377047	broad.mit.edu	37	3	46784041	46784041	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46784041A>G	uc010hjl.2	-	4	486	c.486T>C	c.(484-486)GTT>GTC	p.V162V	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	194	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0																		---	---	---	---
PTH1R	5745	broad.mit.edu	37	3	46944090	46944090	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46944090A>G	uc003cqm.2	+	14	1489	c.1286A>G	c.(1285-1287)TAC>TGC	p.Y429C	PTH1R_uc003cqn.2_Missense_Mutation_p.Y429C	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	429	Extracellular (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1														Ollier_disease_/_Maffuci_syndrome				---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47147559	47147559	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47147559A>G	uc003cqs.2	-	6	4820	c.4767T>C	c.(4765-4767)TTT>TTC	p.F1589F	SETD2_uc003cqv.2_Silent_p.F1578F	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1589	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
KIF9	64147	broad.mit.edu	37	3	47282448	47282448	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47282448A>G	uc010hjp.2	-	18	2371	c.1767T>C	c.(1765-1767)GGT>GGC	p.G589G	KIF9_uc003cqx.2_Silent_p.G589G|KIF9_uc003cqy.2_Silent_p.G524G|KIF9_uc011bat.1_RNA|uc003cqw.1_Intron	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	589					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)														---	---	---	---
KIF9	64147	broad.mit.edu	37	3	47318859	47318859	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47318859A>G	uc010hjp.2	-	3	610	c.6T>C	c.(4-6)GGT>GGC	p.G2G	KIF9_uc003cqx.2_Silent_p.G2G|KIF9_uc003cqy.2_Silent_p.G2G|KIF9_uc011bat.1_RNA|KIF9_uc011bau.1_RNA|KIF9_uc003cra.3_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	2	Kinesin-motor.				blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)														---	---	---	---
PTPN23	25930	broad.mit.edu	37	3	47450682	47450682	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47450682C>T	uc003crf.1	+	17	1768	c.1672C>T	c.(1672-1674)CGC>TGC	p.R558C	PTPN23_uc011baw.1_Missense_Mutation_p.R523C|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Missense_Mutation_p.R428C	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	558	Potential.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47465457	47465457	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47465457C>T	uc003crh.1	-	9	1371	c.1116G>A	c.(1114-1116)CCG>CCA	p.P372P	SCAP_uc011baz.1_Silent_p.P117P|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	372	SSD.|Cytoplasmic (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)														---	---	---	---
SCAP	22937	broad.mit.edu	37	3	47470135	47470135	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47470135A>G	uc003crh.1	-	4	533	c.278T>C	c.(277-279)GTC>GCC	p.V93A	SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	93	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47651722	47651722	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47651722T>C	uc003crq.2	-	26	2995	c.2877A>G	c.(2875-2877)GAA>GAG	p.E959E	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Silent_p.E850E	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	959					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47747936	47747936	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47747936T>C	uc003crq.2	-	10	1121	c.1003A>G	c.(1003-1005)ACA>GCA	p.T335A	SMARCC1_uc011bbd.1_Missense_Mutation_p.T226A	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	335	Poly-Pro.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
DHX30	22907	broad.mit.edu	37	3	47887884	47887884	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47887884A>G	uc003cru.2	+	11	1748	c.1322A>G	c.(1321-1323)GAC>GGC	p.D441G	DHX30_uc003crt.2_Missense_Mutation_p.D402G	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	441						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)														---	---	---	---
DHX30	22907	broad.mit.edu	37	3	47889727	47889727	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47889727C>T	uc003cru.2	+	15	2770	c.2344C>T	c.(2344-2346)CGG>TGG	p.R782W	DHX30_uc003crt.2_Missense_Mutation_p.R743W|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	782	Helicase C-terminal.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)														---	---	---	---
MAP4	4134	broad.mit.edu	37	3	47950531	47950531	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47950531C>T	uc003csb.2	-						MAP4_uc003csc.3_Intron|MAP4_uc011bbf.1_Intron|MAP4_uc003cry.2_Missense_Mutation_p.A401T|MAP4_uc003csa.3_Missense_Mutation_p.A401T|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.A401T	NM_002375	NP_002366			microtubule-associated protein 4 isoform 1						negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)														---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48604159	48604159	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48604159A>G	uc003ctz.2	-	111	8239	c.8238T>C	c.(8236-8238)GGT>GGC	p.G2746G	UCN2_uc003cty.1_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2746	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
COL7A1	1294	broad.mit.edu	37	3	48630051	48630051	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48630051G>T	uc003ctz.2	-	7	929	c.928C>A	c.(928-930)CTC>ATC	p.L310I		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	310	Nonhelical region (NC1).|Fibronectin type-III 1.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48680521	48680521	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48680521G>T	uc003cul.2	-						CELSR3_uc003cuf.1_Intron|CELSR3_uc010hkf.2_Intron|CELSR3_uc010hkg.2_Intron	NM_001407	NP_001398			cadherin EGF LAG seven-pass G-type receptor 3						homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48691211	48691211	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48691211A>G	uc003cul.2	-	9	5570	c.5289T>C	c.(5287-5289)CAT>CAC	p.H1763H	CELSR3_uc003cuf.1_Silent_p.H1833H|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1763	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48696568	48696568	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48696568G>T	uc003cul.2	-	1	3781	c.3500C>A	c.(3499-3501)CCT>CAT	p.P1167H	CELSR3_uc003cuf.1_Missense_Mutation_p.P1237H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1167	Extracellular (Potential).|Cadherin 8.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
LAMB2	3913	broad.mit.edu	37	3	49161917	49161917	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49161917C>T	uc003cwe.2	-	22	3537	c.3238G>A	c.(3238-3240)GCC>ACC	p.A1080T	LAMB2_uc003cwf.1_Missense_Mutation_p.A1080T	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1080	Laminin EGF-like 11.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)														---	---	---	---
CCDC36	339834	broad.mit.edu	37	3	49249252	49249252	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49249252T>C	uc003cwk.2	+	4	426	c.39T>C	c.(37-39)AGT>AGC	p.S13S	CCDC36_uc003cwl.3_Silent_p.S13S|CCDC36_uc011bck.1_Silent_p.S13S|CCDC36_uc010hkt.2_RNA	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	13										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)														---	---	---	---
BSN	8927	broad.mit.edu	37	3	49695210	49695210	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49695210A>G	uc003cxe.3	+	5	8335	c.8221A>G	c.(8221-8223)AGC>GGC	p.S2741G		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2741					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
BSN	8927	broad.mit.edu	37	3	49700635	49700635	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49700635C>T	uc003cxe.3	+	7	11158	c.11044C>T	c.(11044-11046)CAC>TAC	p.H3682Y		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3682					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
BSN	8927	broad.mit.edu	37	3	49701969	49701969	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49701969G>T	uc003cxe.3	+	9	11836	c.11722G>T	c.(11722-11724)GCT>TCT	p.A3908S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3908					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
RNF123	63891	broad.mit.edu	37	3	49734899	49734899	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49734899G>T	uc003cxh.2	+						RNF123_uc010hky.1_5'Flank|RNF123_uc003cxi.2_5'Flank	NM_022064	NP_071347			ring finger protein 123							cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)														---	---	---	---
RNF123	63891	broad.mit.edu	37	3	49737143	49737143	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49737143C>T	uc003cxh.2	+	12	1008	c.922C>T	c.(922-924)CGG>TGG	p.R308W	RNF123_uc010hky.1_5'UTR|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	308						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)														---	---	---	---
MST1R	4486	broad.mit.edu	37	3	49936349	49936349	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49936349C>T	uc003cxy.3	-	3	1763	c.1499G>A	c.(1498-1500)CGG>CAG	p.R500Q	MST1R_uc011bdd.1_Missense_Mutation_p.R500Q|MST1R_uc011bde.1_Missense_Mutation_p.R500Q|MST1R_uc011bdf.1_Intron|MST1R_uc011bdc.1_5'Flank	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	500	Extracellular (Potential).|Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)														---	---	---	---
GNAT1	2779	broad.mit.edu	37	3	50231251	50231251	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50231251G>A	uc003cym.2	+	5	631	c.515G>A	c.(514-516)CGC>CAC	p.R172H	GNAT1_uc003cyl.2_Missense_Mutation_p.R172H	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	172	GTP (By similarity).				detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)														---	---	---	---
IFRD2	7866	broad.mit.edu	37	3	50326260	50326260	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50326260T>C	uc011bdp.1	-	9	1315	c.1186A>G	c.(1186-1188)ACT>GCT	p.T396A	IFRD2_uc003czb.2_Missense_Mutation_p.T498A	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	396							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)														---	---	---	---
HYAL1	3373	broad.mit.edu	37	3	50338063	50338063	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50338063A>G	uc003czp.2	-	4	1291	c.1159T>C	c.(1159-1161)TTC>CTC	p.F387L	HYAL3_uc003czc.1_5'Flank|HYAL3_uc003czd.1_5'Flank|HYAL3_uc003cze.1_5'Flank|HYAL3_uc003czf.1_5'Flank|HYAL3_uc003czg.1_5'Flank|NAT6_uc003czi.2_5'Flank|NAT6_uc003czj.2_5'Flank|NAT6_uc003czk.3_5'Flank|NAT6_uc003czl.1_5'Flank|HYAL1_uc003czm.2_Missense_Mutation_p.F205L|HYAL1_uc003czo.2_Missense_Mutation_p.F128L|HYAL1_uc003czq.2_Missense_Mutation_p.F357L|HYAL1_uc003czr.2_Missense_Mutation_p.F387L|HYAL1_uc003czn.2_Missense_Mutation_p.F48L|HYAL1_uc003czs.2_Missense_Mutation_p.F387L|HYAL1_uc003czt.2_3'UTR	NM_033159	NP_149349	Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1 isoform 1	387	EGF-like.					extracellular space|lysosome	hyalurononglucosaminidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)													---	---	---	---
HYAL2	8692	broad.mit.edu	37	3	50357862	50357862	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50357862G>A	uc003czu.2	-	2	279	c.59C>T	c.(58-60)GCC>GTC	p.A20V	HYAL2_uc003czx.2_Missense_Mutation_p.A20V|HYAL2_uc003czv.2_Missense_Mutation_p.A20V|HYAL2_uc003czw.2_Missense_Mutation_p.A20V|HYAL2_uc010hlj.2_Missense_Mutation_p.A20V	NM_033158	NP_149348	Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2 precursor	20						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)													---	---	---	---
CACNA2D2	9254	broad.mit.edu	37	3	50416569	50416569	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50416569T>C	uc003daq.2	-	12	1252	c.1214A>G	c.(1213-1215)GAC>GGC	p.D405G	CACNA2D2_uc003dap.2_Missense_Mutation_p.D405G	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	405	VWFA.|Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)													---	---	---	---
RBM15B	29890	broad.mit.edu	37	3	51430017	51430017	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51430017C>T	uc003dbd.2	+	1	1287	c.1187C>T	c.(1186-1188)GCC>GTC	p.A396V		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	396	RRM 2.				interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
TLR9	54106	broad.mit.edu	37	3	52256132	52256132	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52256132C>T	uc003dda.1	-	2	2834	c.2200G>A	c.(2200-2202)GCC>ACC	p.A734T	TLR9_uc003ddb.2_Missense_Mutation_p.A831T	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	734	LRR 25.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)													---	---	---	---
TLR9	54106	broad.mit.edu	37	3	52257592	52257592	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52257592C>T	uc003dda.1	-	2	1374	c.740G>A	c.(739-741)CGT>CAT	p.R247H	TLR9_uc003ddb.2_Missense_Mutation_p.R344H	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	247	LRR 8.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)													---	---	---	---
TLR9	54106	broad.mit.edu	37	3	52258032	52258032	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52258032C>T	uc003dda.1	-	2	934	c.300G>A	c.(298-300)CCG>CCA	p.P100P	TLR9_uc003ddb.2_Silent_p.P197P|TLR9_uc003ddc.1_Silent_p.P85P	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	100	LRR 2.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)													---	---	---	---
TWF2	11344	broad.mit.edu	37	3	52265209	52265209	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52265209C>T	uc003ddd.2	-	5	568	c.417G>A	c.(415-417)TCG>TCA	p.S139S	TLR9_uc003ddb.2_5'UTR|TLR9_uc003ddc.1_5'Flank|TWF2_uc010hmc.2_Silent_p.S139S	NM_007284	NP_009215	Q6IBS0	TWF2_HUMAN	twinfilin-like protein	139	ADF-H 1.					cytoskeleton|perinuclear region of cytoplasm	actin binding|ATP binding			stomach(1)|ovary(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;2.43e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
BAP1	8314	broad.mit.edu	37	3	52439911	52439911	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52439911C>T	uc003ddx.2	-	10	916	c.801G>A	c.(799-801)CAG>CAA	p.Q267Q	BAP1_uc003ddw.2_5'Flank|BAP1_uc010hmg.2_5'Flank|BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	267					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)				N|Mis|F|S|O		uveal melanoma|breast|NSCLC								---	---	---	---
SEMA3G	56920	broad.mit.edu	37	3	52469661	52469661	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52469661A>G	uc003dea.1	-	16	2307	c.2307T>C	c.(2305-2307)CAT>CAC	p.H769H		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	769					multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)														---	---	---	---
SEMA3G	56920	broad.mit.edu	37	3	52475363	52475363	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52475363A>G	uc003dea.1	-	7	730	c.730T>C	c.(730-732)TAC>CAC	p.Y244H		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	244	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)														---	---	---	---
TNNC1	7134	broad.mit.edu	37	3	52485421	52485421	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52485421C>T	uc003deb.2	-	5	466	c.440G>A	c.(439-441)CGC>CAC	p.R147H		NM_003280	NP_003271	P63316	TNNC1_HUMAN	troponin C, slow	147	3.|EF-hand 4.				cardiac muscle contraction|muscle filament sliding|regulation of ATPase activity|regulation of muscle filament sliding speed|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin filament binding|calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|troponin I binding|troponin T binding				0				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00175)|KIRC - Kidney renal clear cell carcinoma(197;0.00198)|OV - Ovarian serous cystadenocarcinoma(275;0.0525)	Bepridil(DB01244)|Dihydroxyaluminium(DB01375)|Levosimendan(DB00922)													---	---	---	---
NT5DC2	64943	broad.mit.edu	37	3	52563198	52563198	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52563198T>C	uc003deo.2	-	2	698	c.274A>G	c.(274-276)ACC>GCC	p.T92A	NT5DC2_uc003dem.2_5'Flank|NT5DC2_uc003den.2_Missense_Mutation_p.T129A|NT5DC2_uc010hmi.2_Missense_Mutation_p.T129A|NT5DC2_uc010hmj.2_5'UTR	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	92							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)														---	---	---	---
PBRM1	55193	broad.mit.edu	37	3	52637747	52637747	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52637747T>C	uc003des.2	-	17	2581	c.2569A>G	c.(2569-2571)ACA>GCA	p.T857A	PBRM1_uc003dex.2_Intron|PBRM1_uc003deq.2_Missense_Mutation_p.T857A|PBRM1_uc003der.2_Missense_Mutation_p.T825A|PBRM1_uc003det.2_Missense_Mutation_p.T872A|PBRM1_uc003deu.2_Missense_Mutation_p.T872A|PBRM1_uc003dev.2_Intron|PBRM1_uc003dew.2_Missense_Mutation_p.T857A|PBRM1_uc010hmk.1_Missense_Mutation_p.T857A|PBRM1_uc003dey.2_Missense_Mutation_p.T857A|PBRM1_uc003dez.1_Missense_Mutation_p.T857A|PBRM1_uc003dfb.1_Missense_Mutation_p.T770A|PBRM1_uc003dfa.1_Missense_Mutation_p.T203A	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	857	Bromo 6.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)				Mis|N|F|S|D|O		clear cell renal carcinoma|breast								---	---	---	---
NEK4	6787	broad.mit.edu	37	3	52777458	52777458	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52777458C>T	uc003dfq.3	-	12	2103	c.1914G>A	c.(1912-1914)GCG>GCA	p.A638A	NEK4_uc011bej.1_Silent_p.A549A|NEK4_uc003dfr.2_Silent_p.A592A	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	638					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)														---	---	---	---
ITIH1	3697	broad.mit.edu	37	3	52823759	52823759	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52823759A>G	uc003dfs.2	+	19	2234	c.2210A>G	c.(2209-2211)AAC>AGC	p.N737S	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Missense_Mutation_p.N338S|ITIH1_uc010hmo.1_Missense_Mutation_p.N291S|ITIH1_uc003dfu.2_Missense_Mutation_p.N103S	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	737	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)														---	---	---	---
CACNA1D	776	broad.mit.edu	37	3	53694220	53694220	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53694220C>T	uc003dgv.3	+	5	847	c.684C>T	c.(682-684)AGC>AGT	p.S228S	CACNA1D_uc003dgu.3_Silent_p.S228S|CACNA1D_uc003dgy.3_Silent_p.S228S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	228	Extracellular (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)													---	---	---	---
CACNA1D	776	broad.mit.edu	37	3	53844236	53844236	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53844236A>G	uc003dgv.3	+	47	6266	c.6103A>G	c.(6103-6105)ACT>GCT	p.T2035A	CACNA1D_uc003dgu.3_Missense_Mutation_p.T2055A|CACNA1D_uc003dgy.3_Missense_Mutation_p.T2011A|CACNA1D_uc003dgw.3_Missense_Mutation_p.T1702A|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	2035	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)													---	---	---	---
CHDH	55349	broad.mit.edu	37	3	53851805	53851805	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53851805T>C	uc003dgz.2	-	9	2224	c.1784A>G	c.(1783-1785)TAA>TGA	p.*595*		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	595					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)													---	---	---	---
CHDH	55349	broad.mit.edu	37	3	53856520	53856520	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53856520T>C	uc003dgz.2	-	4	1293	c.853A>G	c.(853-855)AGG>GGG	p.R285G		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	285					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)													---	---	---	---
CACNA2D3	55799	broad.mit.edu	37	3	54661852	54661852	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54661852A>G	uc003dhf.2	+	10	1050	c.1002A>G	c.(1000-1002)GGA>GGG	p.G334G	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Silent_p.G240G|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Silent_p.G68G	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	334	Extracellular (Potential).|VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)														---	---	---	---
CACNA2D3	55799	broad.mit.edu	37	3	54919520	54919520	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54919520T>C	uc003dhf.2	+	23	2011	c.1963T>C	c.(1963-1965)TAC>CAC	p.Y655H	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.Y561H|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.Y389H|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	655	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)														---	---	---	---
LRTM1	57408	broad.mit.edu	37	3	54959015	54959015	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54959015A>G	uc003dhl.2	-	2	369	c.235T>C	c.(235-237)TTA>CTA	p.L79L	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	79	Extracellular (Potential).|LRR 2.					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)														---	---	---	---
WNT5A	7474	broad.mit.edu	37	3	55513396	55513396	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:55513396A>G	uc003dhn.2	-	3	655	c.337T>C	c.(337-339)TGG>CGG	p.W113R	WNT5A_uc003dhm.2_Missense_Mutation_p.W98R|WNT5A_uc010hmw.2_Missense_Mutation_p.W98R|WNT5A_uc010hmx.2_Missense_Mutation_p.W24R	NM_003392	NP_003383	P41221	WNT5A_HUMAN	wingless-type MMTV integration site family,	113					activation of JUN kinase activity|activation of protein kinase B activity|axon guidance|cartilage development|cellular protein localization|cellular response to calcium ion|cellular response to interferon-gamma|cellular response to lipopolysaccharide|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|cervix development|cochlea morphogenesis|convergent extension involved in organogenesis|dopaminergic neuron differentiation|dorsal/ventral axis specification|embryonic digit morphogenesis|embryonic skeletal system development|epithelial cell proliferation involved in mammary gland duct elongation|epithelial to mesenchymal transition|face development|genitalia development|heart looping|hemopoietic stem cell proliferation|keratinocyte differentiation|lateral sprouting involved in mammary gland duct morphogenesis|lens development in camera-type eye|male gonad development|mammary gland branching involved in thelarche|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of transcription, DNA-dependent|neural tube closure|olfactory bulb interneuron development|optic cup formation involved in camera-type eye development|palate development|positive regulation of angiogenesis|positive regulation of cartilage development|positive regulation of cGMP metabolic process|positive regulation of chemokine biosynthetic process|positive regulation of cytokine secretion involved in immune response|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of macrophage activation|positive regulation of macrophage cytokine production|positive regulation of mesenchymal cell proliferation|positive regulation of neuron projection development|positive regulation of NF-kappaB transcription factor activity|positive regulation of ossification|positive regulation of protein catabolic process|positive regulation of protein kinase C signaling cascade|positive regulation of T cell chemotaxis|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|primitive streak formation|regulation of branching involved in mammary gland duct morphogenesis|somitogenesis|tail morphogenesis|type B pancreatic cell development|urinary bladder development|uterus development|vagina development|Wnt receptor signaling pathway, calcium modulating pathway|wound healing	extracellular space|membrane fraction|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|receptor tyrosine kinase-like orphan receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.00377)|Kidney(284;0.00408)|OV - Ovarian serous cystadenocarcinoma(275;0.204)														---	---	---	---
ERC2	26059	broad.mit.edu	37	3	56053068	56053068	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56053068A>G	uc003dhr.1	-						ERC2_uc003dht.1_Intron	NM_015576	NP_056391			cytomatrix protein p110							cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)														---	---	---	---
C3orf63	23272	broad.mit.edu	37	3	56681185	56681185	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56681185A>G	uc003did.3	-	14	1681	c.1580T>C	c.(1579-1581)ATA>ACA	p.I527T	C3orf63_uc003dic.3_Missense_Mutation_p.I131T|C3orf63_uc003die.3_Missense_Mutation_p.I527T	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	527										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)														---	---	---	---
APPL1	26060	broad.mit.edu	37	3	57294173	57294173	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57294173A>G	uc003dio.2	+	18	1834	c.1687A>G	c.(1687-1689)AGG>GGG	p.R563G	APPL1_uc010hnb.2_Missense_Mutation_p.R563G|APPL1_uc011bey.1_Missense_Mutation_p.R546G	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	563	PID.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)														---	---	---	---
FLNB	2317	broad.mit.edu	37	3	58110079	58110079	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58110079A>G	uc003djj.2	+	22	3910	c.3745A>G	c.(3745-3747)ACC>GCC	p.T1249A	FLNB_uc010hne.2_Missense_Mutation_p.T1249A|FLNB_uc003djk.2_Missense_Mutation_p.T1249A|FLNB_uc010hnf.2_Missense_Mutation_p.T1249A|FLNB_uc003djl.2_Missense_Mutation_p.T1080A|FLNB_uc003djm.2_Missense_Mutation_p.T1080A	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1249	Filamin 11.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)														---	---	---	---
FLNB	2317	broad.mit.edu	37	3	58131754	58131754	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58131754C>T	uc003djj.2	+	33	5697	c.5532C>T	c.(5530-5532)ATC>ATT	p.I1844I	FLNB_uc010hne.2_Silent_p.I1875I|FLNB_uc003djk.2_Silent_p.I1833I|FLNB_uc010hnf.2_Silent_p.I1820I|FLNB_uc003djl.2_Silent_p.I1664I|FLNB_uc003djm.2_Silent_p.I1651I	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1844	Filamin 17.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)														---	---	---	---
ABHD6	57406	broad.mit.edu	37	3	58260523	58260523	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58260523G>A	uc003djs.3	+	6	1072	c.662G>A	c.(661-663)CGC>CAC	p.R221H	ABHD6_uc003djr.2_Missense_Mutation_p.R221H|ABHD6_uc003djt.3_Missense_Mutation_p.R221H	NM_020676	NP_065727	Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	221	Cytoplasmic (Potential).					integral to membrane	acylglycerol lipase activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)														---	---	---	---
C3orf67	200844	broad.mit.edu	37	3	58870331	58870331	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58870331T>C	uc003dkt.1	-	7	689	c.280A>G	c.(280-282)ACT>GCT	p.T94A	uc003dku.1_Intron|C3orf67_uc003dkv.1_5'UTR|C3orf67_uc003dkw.2_Missense_Mutation_p.T2A	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	hypothetical protein LOC200844	94											0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)														---	---	---	---
PTPRG	5793	broad.mit.edu	37	3	61975397	61975397	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:61975397G>A	uc003dlb.2	+	3	1008	c.289G>A	c.(289-291)GAA>AAA	p.E97K	PTPRG_uc003dlc.2_Missense_Mutation_p.E97K	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	97	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)														---	---	---	---
CADPS	8618	broad.mit.edu	37	3	62452032	62452032	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62452032T>A	uc003dll.2	-	25	3894	c.3534A>T	c.(3532-3534)ATA>ATT	p.I1178I	CADPS_uc003dlj.1_Silent_p.I133I|CADPS_uc003dlk.1_Silent_p.I626I|CADPS_uc003dlm.2_Silent_p.I1139I|CADPS_uc003dln.2_Silent_p.I1099I	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	1178	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)														---	---	---	---
THOC7	80145	broad.mit.edu	37	3	63824156	63824156	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63824156T>C	uc003dlt.3	-	3	288	c.157A>G	c.(157-159)ATG>GTG	p.M53V	C3orf49_uc003dls.3_Intron|THOC7_uc003dlu.3_5'UTR	NM_025075	NP_079351	Q6I9Y2	THOC7_HUMAN	Ngg1 interacting factor 3 like 1 binding protein	53	Interaction with THOC5.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	cytoplasm|THO complex part of transcription export complex	protein binding|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000439)|Kidney(15;0.00194)|KIRC - Kidney renal clear cell carcinoma(15;0.00218)														---	---	---	---
ATXN7	6314	broad.mit.edu	37	3	63898589	63898589	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63898589T>C	uc003dlw.3	+	3	868	c.315T>C	c.(313-315)CCT>CCC	p.P105P	ATXN7_uc003dlv.2_Silent_p.P105P|ATXN7_uc010hnv.2_Silent_p.P105P|ATXN7_uc010hnu.1_RNA	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	105				P -> H (in Ref. 2; AAC19162).	cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)														---	---	---	---
ATXN7	6314	broad.mit.edu	37	3	63976414	63976414	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63976414T>C	uc003dlw.3	+	11	2114	c.1561T>C	c.(1561-1563)TTT>CTT	p.F521L	ATXN7_uc003dlv.2_Missense_Mutation_p.F521L|ATXN7_uc010hnv.2_Missense_Mutation_p.F521L|ATXN7_uc011bfn.1_Missense_Mutation_p.F376L	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	521					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)														---	---	---	---
PRICKLE2	166336	broad.mit.edu	37	3	64085149	64085149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64085149G>A	uc003dmf.2	-	8	2699	c.2113C>T	c.(2113-2115)CGC>TGC	p.R705C		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	705	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64547309	64547309	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64547309T>C	uc003dmg.2	-	30	4675	c.4643A>G	c.(4642-4644)GAC>GGC	p.D1548G	ADAMTS9_uc011bfo.1_Missense_Mutation_p.D1520G|ADAMTS9_uc003dmh.1_Missense_Mutation_p.D1377G|ADAMTS9_uc011bfp.1_Missense_Mutation_p.D459G|uc003dmi.1_5'Flank	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1548	TSP type-1 12.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64582593	64582593	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64582593G>A	uc003dmg.2	-	27	4124	c.4092C>T	c.(4090-4092)AAC>AAT	p.N1364N	ADAMTS9_uc011bfo.1_Silent_p.N1336N|ADAMTS9_uc003dmh.1_Silent_p.N1193N|ADAMTS9_uc011bfp.1_Silent_p.N275N	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1364	TSP type-1 9.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64601627	64601627	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64601627C>T	uc003dmg.2	-						ADAMTS9_uc011bfo.1_Intron|ADAMTS9_uc003dmh.1_Intron|ADAMTS9_uc003dmk.1_Intron|ADAMTS9_uc011bfp.1_Intron	NM_182920	NP_891550			ADAM metallopeptidase with thrombospondin type 1						glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64619438	64619438	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64619438G>A	uc003dmg.2	-	13	2006	c.1974C>T	c.(1972-1974)GAC>GAT	p.D658D	ADAMTS9_uc011bfo.1_Silent_p.D630D|ADAMTS9_uc003dmh.1_Silent_p.D487D|ADAMTS9_uc003dmk.1_Silent_p.D658D	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	658	Cys-rich.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64636769	64636769	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64636769C>T	uc003dmg.2	-	9	1419	c.1387G>A	c.(1387-1389)GCT>ACT	p.A463T	ADAMTS9_uc011bfo.1_Missense_Mutation_p.A435T|ADAMTS9_uc003dmh.1_Missense_Mutation_p.A292T|ADAMTS9_uc003dmk.1_Missense_Mutation_p.A463T	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	463	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	65342381	65342381	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65342381C>A	uc003dmn.2	-	23	4587	c.4061G>T	c.(4060-4062)AGG>ATG	p.R1354M	MAGI1_uc003dmm.2_3'UTR	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1383					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
LRIG1	26018	broad.mit.edu	37	3	66463397	66463397	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:66463397G>T	uc003dmx.2	-	6	703	c.689C>A	c.(688-690)ACC>AAC	p.T230N	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Missense_Mutation_p.T230N	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	230	Extracellular (Potential).|LRR 7.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)														---	---	---	---
FAM19A4	151647	broad.mit.edu	37	3	68929977	68929977	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:68929977A>G	uc003dnh.1	-	3	477	c.34T>C	c.(34-36)TCA>CCA	p.S12P	FAM19A4_uc003dni.1_Missense_Mutation_p.S12P	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	12						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)														---	---	---	---
FOXP1	27086	broad.mit.edu	37	3	71247404	71247404	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71247404G>A	uc003dol.2	-	2	452	c.129C>T	c.(127-129)GCC>GCT	p.A43A	FOXP1_uc003dom.2_Silent_p.A43A|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Silent_p.A43A|FOXP1_uc003dop.2_Silent_p.A43A|FOXP1_uc003doq.1_Silent_p.A43A|FOXP1_uc003dos.2_Silent_p.A43A	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	43					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)				T	PAX5	ALL								---	---	---	---
EIF4E3	317649	broad.mit.edu	37	3	71739244	71739244	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71739244G>A	uc003dov.3	-	6	553	c.545C>T	c.(544-546)GCC>GTC	p.A182V	EIF4E3_uc011bgc.1_Missense_Mutation_p.A76V|EIF4E3_uc003dox.2_Missense_Mutation_p.A76V|EIF4E3_uc011bgd.1_Missense_Mutation_p.A76V|EIF4E3_uc010hoc.2_Missense_Mutation_p.A76V	NM_001134651	NP_001128123	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E	182					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)														---	---	---	---
EIF4E3	317649	broad.mit.edu	37	3	71748797	71748797	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:71748797A>G	uc003dov.3	-	3	320	c.312T>C	c.(310-312)TAT>TAC	p.Y104Y	EIF4E3_uc011bgc.1_5'UTR|EIF4E3_uc003dox.2_5'UTR|EIF4E3_uc011bgd.1_5'UTR|EIF4E3_uc010hoc.2_5'UTR	NM_001134651	NP_001128123	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E	104					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)														---	---	---	---
SHQ1	55164	broad.mit.edu	37	3	72866546	72866546	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:72866546A>G	uc003dpf.2	-						SHQ1_uc010hod.2_Intron	NM_018130	NP_060600			SHQ1 homolog						ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)														---	---	---	---
PDZRN3	23024	broad.mit.edu	37	3	73433573	73433573	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:73433573T>C	uc003dpl.1	-	10	2240	c.2144A>G	c.(2143-2145)TAC>TGC	p.Y715C	PDZRN3_uc011bgh.1_Missense_Mutation_p.Y372C|PDZRN3_uc010hoe.1_Missense_Mutation_p.Y413C|PDZRN3_uc011bgf.1_Missense_Mutation_p.Y432C|PDZRN3_uc011bgg.1_Missense_Mutation_p.Y435C	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	715							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)														---	---	---	---
CNTN3	5067	broad.mit.edu	37	3	74419034	74419034	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:74419034A>G	uc003dpm.1	-							NM_020872	NP_065923			contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)														---	---	---	---
ROBO2	6092	broad.mit.edu	37	3	77595619	77595619	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:77595619T>A	uc003dpy.3	+						ROBO2_uc003dpz.2_Intron|ROBO2_uc011bgj.1_Intron|ROBO2_uc011bgk.1_Intron	NM_002942	NP_002933			roundabout, axon guidance receptor, homolog 2						apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)														---	---	---	---
ROBO2	6092	broad.mit.edu	37	3	77617497	77617497	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:77617497G>T	uc003dpy.3	+	13	2526	c.1883G>T	c.(1882-1884)AGG>ATG	p.R628M	ROBO2_uc003dpz.2_Missense_Mutation_p.R632M|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.R632M	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	628	Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)														---	---	---	---
VGLL3	389136	broad.mit.edu	37	3	87017791	87017791	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:87017791C>T	uc003dqn.2	-	3	1250	c.886G>A	c.(886-888)GGA>AGA	p.G296R		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89391170	89391170	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89391170T>C	uc003dqy.2	+	5	1461	c.1236T>C	c.(1234-1236)GTT>GTC	p.V412V	EPHA3_uc003dqx.1_Silent_p.V412V|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	412	Extracellular (Potential).|Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
PROS1	5627	broad.mit.edu	37	3	93598107	93598107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93598107C>T	uc003drb.3	-	13	1885	c.1544G>A	c.(1543-1545)CGT>CAT	p.R515H	PROS1_uc010hoo.2_Missense_Mutation_p.R384H|PROS1_uc003dqz.3_Missense_Mutation_p.R384H	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	515	Laminin G-like 2.		R -> P (in PROS1D).|R -> C (in PROS1D; secretion of the mutant markedly decreased compared with that of the wild-type; intracellular degradation and impaired secretion of the mutant).	R->K: No change in secretion of the mutant.|R->A,E: Markedly reduced secretion of the mutant.	leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)													---	---	---	---
PROS1	5627	broad.mit.edu	37	3	93615522	93615522	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93615522C>T	uc003drb.3	-	9	1204	c.863G>A	c.(862-864)TGC>TAC	p.C288Y	PROS1_uc010hoo.2_Missense_Mutation_p.C157Y|PROS1_uc003dqz.3_Missense_Mutation_p.C157Y	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	288					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)													---	---	---	---
ARL13B	200894	broad.mit.edu	37	3	93754252	93754252	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:93754252T>C	uc003drc.2	+	4	744	c.458T>C	c.(457-459)GTC>GCC	p.V153A	ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Missense_Mutation_p.V46A|ARL13B_uc003dre.2_Missense_Mutation_p.V138A|ARL13B_uc003drf.2_Missense_Mutation_p.V153A|ARL13B_uc003drg.2_Missense_Mutation_p.V50A	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	153							GTP binding				0																		---	---	---	---
EPHA6	285220	broad.mit.edu	37	3	97367155	97367155	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97367155A>G	uc010how.1	+						EPHA6_uc003drs.3_Missense_Mutation_p.N329S|EPHA6_uc003drr.3_Missense_Mutation_p.N393S|EPHA6_uc003drt.2_Intron|EPHA6_uc010hox.1_Intron	NM_001080448	NP_001073917			EPH receptor A6 isoform a							integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16																		---	---	---	---
EPHA6	285220	broad.mit.edu	37	3	97439147	97439147	+	Missense_Mutation	SNP	G	A	A	rs36084843		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97439147G>A	uc010how.1	+	15	2870	c.2827G>A	c.(2827-2829)GCC>ACC	p.A943T	EPHA6_uc003drt.2_Missense_Mutation_p.A335T|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	848	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16																		---	---	---	---
GABRR3	200959	broad.mit.edu	37	3	97711803	97711803	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97711803A>G	uc011bgr.1	-	8	997	c.997T>C	c.(997-999)TAC>CAC	p.Y333H		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	333	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0																		---	---	---	---
OR5H15	403274	broad.mit.edu	37	3	97888382	97888382	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97888382T>C	uc011bgu.1	+	1	839	c.839T>C	c.(838-840)GTC>GCC	p.V280A		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
GPR15	2838	broad.mit.edu	37	3	98251737	98251737	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:98251737G>A	uc011bgy.1	+	1	860	c.860G>A	c.(859-861)AGT>AAT	p.S287N		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	287	Helical; Name=7; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)														---	---	---	---
ABI3BP	25890	broad.mit.edu	37	3	100566439	100566439	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100566439T>C	uc003dun.2	-						ABI3BP_uc003duo.2_Intron|ABI3BP_uc011bhd.1_5'Flank|ABI3BP_uc003dum.2_5'Flank	NM_015429	NP_056244			ABI gene family, member 3 (NESH) binding protein							extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101060559	101060559	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101060559T>C	uc003dut.2	-	15	2282	c.2171A>G	c.(2170-2172)TAC>TGC	p.Y724C	SENP7_uc003duu.2_Missense_Mutation_p.Y659C|SENP7_uc003duv.2_Missense_Mutation_p.Y691C|SENP7_uc003duw.2_Missense_Mutation_p.Y658C|SENP7_uc003dux.2_Missense_Mutation_p.Y560C	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	724					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
SENP7	57337	broad.mit.edu	37	3	101083732	101083732	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101083732A>G	uc003dut.2	-	10	1533	c.1422T>C	c.(1420-1422)AGT>AGC	p.S474S	SENP7_uc003duu.2_Silent_p.S409S|SENP7_uc003duv.2_Silent_p.S441S|SENP7_uc003duw.2_Silent_p.S408S|SENP7_uc003dux.2_Silent_p.S310S	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	474					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5																		---	---	---	---
ZBTB11	27107	broad.mit.edu	37	3	101384247	101384247	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101384247G>A	uc003dve.3	-	4	1414	c.1184C>T	c.(1183-1185)GCC>GTC	p.A395V		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1																		---	---	---	---
ALCAM	214	broad.mit.edu	37	3	105271332	105271332	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105271332A>G	uc003dvx.2	+	14	2107	c.1567A>G	c.(1567-1569)AAT>GAT	p.N523D	ALCAM_uc003dvw.1_Missense_Mutation_p.N523D|ALCAM_uc003dvy.2_Missense_Mutation_p.N510D|ALCAM_uc010hpp.2_Missense_Mutation_p.N245D|ALCAM_uc003dvz.2_Missense_Mutation_p.N157D	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	523	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3																		---	---	---	---
CBLB	868	broad.mit.edu	37	3	105400628	105400628	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105400628T>C	uc003dwc.2	-	15	2558	c.2236A>G	c.(2236-2238)ACA>GCA	p.T746A	CBLB_uc003dwa.2_Missense_Mutation_p.T5A|CBLB_uc011bhi.1_Missense_Mutation_p.T768A|CBLB_uc003dwd.1_Missense_Mutation_p.T746A|CBLB_uc003dwe.1_Missense_Mutation_p.T746A	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	746	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9								Mis S		AML								---	---	---	---
IFT57	55081	broad.mit.edu	37	3	107938290	107938290	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:107938290T>C	uc003dwx.3	-	2	590	c.342A>G	c.(340-342)ACA>ACG	p.T114T		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	114					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)															---	---	---	---
IFT57	55081	broad.mit.edu	37	3	107941070	107941070	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:107941070G>A	uc003dwx.3	-	1	348	c.100C>T	c.(100-102)CCC>TCC	p.P34S		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	34					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)															---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108147575	108147575	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108147575T>C	uc003dxa.1	-	28	3583	c.3526A>G	c.(3526-3528)ACT>GCT	p.T1176A		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1176	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108224573	108224573	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108224573T>C	uc003dxa.1	-	3	309	c.252A>G	c.(250-252)GGA>GGG	p.G84G		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	84	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
KIAA1524	57650	broad.mit.edu	37	3	108282076	108282076	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108282076T>C	uc003dxb.3	-	13	1800	c.1531A>G	c.(1531-1533)ACT>GCT	p.T511A	KIAA1524_uc010hpv.1_Missense_Mutation_p.T78A	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	511						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
MORC1	27136	broad.mit.edu	37	3	108682336	108682336	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108682336A>T	uc003dxl.2	-	27	2811	c.2724T>A	c.(2722-2724)AAT>AAA	p.N908K	MORC1_uc011bhn.1_Missense_Mutation_p.N887K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	908	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8																		---	---	---	---
DPPA4	55211	broad.mit.edu	37	3	109047759	109047759	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:109047759A>T	uc003dxq.3	-	6	911	c.856T>A	c.(856-858)TTG>ATG	p.L286M	DPPA4_uc011bho.1_3'UTR	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	286						nucleus	protein binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
SLC9A10	285335	broad.mit.edu	37	3	111927065	111927065	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111927065T>C	uc003dyu.2	-	16	2168	c.1946A>G	c.(1945-1947)TAC>TGC	p.Y649C	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.Y601C	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	649	Helical; (Potential).|Ion transport-like.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5																		---	---	---	---
SLC9A10	285335	broad.mit.edu	37	3	111997623	111997623	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111997623T>C	uc003dyu.2	-	4	493	c.271A>G	c.(271-273)ACT>GCT	p.T91A	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.T91A	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	91	Helical; (Potential).				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5																		---	---	---	---
SLC9A10	285335	broad.mit.edu	37	3	111999519	111999519	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111999519A>G	uc003dyu.2	-						SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Intron	NM_183061	NP_898884			sperm-specific sodium proton exchanger						cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5																		---	---	---	---
CCDC80	151887	broad.mit.edu	37	3	112324479	112324479	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112324479G>T	uc003dzf.2	-	8	2856	c.2638C>A	c.(2638-2640)CCT>ACT	p.P880T	CCDC80_uc011bhv.1_Missense_Mutation_p.P853T|CCDC80_uc003dzg.2_Missense_Mutation_p.P880T	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	880										ovary(2)	2																		---	---	---	---
WDR52	55779	broad.mit.edu	37	3	113115503	113115503	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113115503A>T	uc003eae.1	-	14	1687	c.1641T>A	c.(1639-1641)GAT>GAA	p.D547E		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	547	WD 6.									central_nervous_system(1)	1																		---	---	---	---
CCDC52	152185	broad.mit.edu	37	3	113184570	113184570	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113184570T>C	uc003eag.3	-	11	1508	c.1217A>G	c.(1216-1218)GAT>GGT	p.D406G	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.D302G	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	406	Potential.				cell division|mitosis	centriole|spindle	protein binding				0																		---	---	---	---
SIDT1	54847	broad.mit.edu	37	3	113321913	113321913	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113321913G>A	uc003eak.2	+	12	1830	c.1179G>A	c.(1177-1179)CAG>CAA	p.Q393Q	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Silent_p.Q393Q|SIDT1_uc011big.1_Silent_p.Q146Q|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	393	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5																		---	---	---	---
SIDT1	54847	broad.mit.edu	37	3	113329934	113329934	+	Silent	SNP	C	T	T	rs145430934		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113329934C>T	uc003eak.2	+	18	2451	c.1800C>T	c.(1798-1800)AGC>AGT	p.S600S	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Silent_p.S600S|SIDT1_uc011big.1_Silent_p.S353S|SIDT1_uc011bih.1_RNA|SIDT1_uc011bii.1_Silent_p.S53S	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	600	Cytoplasmic (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5																		---	---	---	---
DRD3	1814	broad.mit.edu	37	3	113847607	113847607	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113847607T>C	uc003ebd.2	-	8	1582	c.1159A>G	c.(1159-1161)AAT>GAT	p.N387D	DRD3_uc010hqn.1_Missense_Mutation_p.N387D|DRD3_uc003ebb.1_Missense_Mutation_p.N354D|DRD3_uc003ebc.1_Missense_Mutation_p.N387D	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	387	Helical; Name=7.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)													---	---	---	---
DRD3	1814	broad.mit.edu	37	3	113890604	113890604	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113890604G>A	uc003ebd.2	-	3	659	c.236C>T	c.(235-237)GCC>GTC	p.A79V	DRD3_uc010hqn.1_Missense_Mutation_p.A79V|DRD3_uc003ebb.1_Missense_Mutation_p.A79V|DRD3_uc003ebc.1_Missense_Mutation_p.A79V	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	79	Helical; Name=2.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)													---	---	---	---
MIR568	693153	broad.mit.edu	37	3	114035389	114035389	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114035389T>C	hsa-mir-568|MI0003574	-			c.28T>C			uc003ebh.1_RNA																	0																		---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114069373	114069373	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114069373C>T	uc003ebi.2	-	4	1732	c.1552G>A	c.(1552-1554)GGC>AGC	p.G518S	ZBTB20_uc003ebj.2_Missense_Mutation_p.G445S|ZBTB20_uc010hqp.2_Missense_Mutation_p.G445S|ZBTB20_uc003ebk.2_Missense_Mutation_p.G445S|ZBTB20_uc003ebl.2_Missense_Mutation_p.G445S|ZBTB20_uc003ebm.2_Missense_Mutation_p.G445S|ZBTB20_uc003ebn.2_Missense_Mutation_p.G445S|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114069493	114069493	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114069493G>A	uc003ebi.2	-	4	1612	c.1432C>T	c.(1432-1434)CGC>TGC	p.R478C	ZBTB20_uc003ebj.2_Missense_Mutation_p.R405C|ZBTB20_uc010hqp.2_Missense_Mutation_p.R405C|ZBTB20_uc003ebk.2_Missense_Mutation_p.R405C|ZBTB20_uc003ebl.2_Missense_Mutation_p.R405C|ZBTB20_uc003ebm.2_Missense_Mutation_p.R405C|ZBTB20_uc003ebn.2_Missense_Mutation_p.R405C|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
B4GALT4	8702	broad.mit.edu	37	3	118945806	118945806	+	Silent	SNP	C	T	T	rs143371634	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118945806C>T	uc003ecg.2	-	4	977	c.336G>A	c.(334-336)CGG>CGA	p.R112R	B4GALT4_uc003ece.1_Silent_p.R112R|B4GALT4_uc003ecf.2_RNA|B4GALT4_uc003ech.2_Silent_p.R112R|B4GALT4_uc003eci.2_Silent_p.R112R|B4GALT4_uc011biy.1_RNA	NM_212543	NP_997708	O60513	B4GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	112	Lumenal (Potential).				membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity				0				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)													---	---	---	---
ARHGAP31	57514	broad.mit.edu	37	3	119120876	119120876	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119120876G>A	uc003ecj.3	+	10	1809	c.1277G>A	c.(1276-1278)CGG>CAG	p.R426Q		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	426					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2																		---	---	---	---
ARHGAP31	57514	broad.mit.edu	37	3	119121036	119121036	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119121036C>T	uc003ecj.3	+	10	1969	c.1437C>T	c.(1435-1437)AAC>AAT	p.N479N		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	479					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2																		---	---	---	---
C3orf15	89876	broad.mit.edu	37	3	119452224	119452224	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119452224T>C	uc003ede.3	+	10	1292	c.1215T>C	c.(1213-1215)CTT>CTC	p.L405L	C3orf15_uc010hqy.1_Silent_p.L405L|C3orf15_uc010hqz.2_Silent_p.L343L|C3orf15_uc011bjd.1_Silent_p.L279L|C3orf15_uc011bje.1_Silent_p.L385L|C3orf15_uc010hra.1_Silent_p.L166L	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	Error:Variant_position_missing_in_Q7Z4T9_after_alignment						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)														---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121207128	121207128	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121207128A>G	uc003eee.3	-	16	4779	c.4650T>C	c.(4648-4650)TGT>TGC	p.C1550C	POLQ_uc003eed.2_Silent_p.C722C	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1550					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121263572	121263572	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121263572A>G	uc003eee.3	-	2	472	c.343_splice	c.e2+1	p.A115_splice		NM_199420	NP_955452			DNA polymerase theta						DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
GOLGB1	2804	broad.mit.edu	37	3	121409831	121409831	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121409831C>T	uc003eei.3	-	14	8491	c.8365G>A	c.(8365-8367)GCC>ACC	p.A2789T	GOLGB1_uc010hrc.2_Missense_Mutation_p.A2794T|GOLGB1_uc003eej.3_Missense_Mutation_p.A2755T	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2789	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding	p.A2789T(1)		ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)														---	---	---	---
GOLGB1	2804	broad.mit.edu	37	3	121415161	121415161	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121415161T>C	uc003eei.3	-	13	4320	c.4194A>G	c.(4192-4194)CAA>CAG	p.Q1398Q	GOLGB1_uc010hrc.2_Silent_p.Q1403Q|GOLGB1_uc003eej.3_Silent_p.Q1364Q|GOLGB1_uc011bjm.1_Silent_p.Q1284Q|GOLGB1_uc010hrd.1_Silent_p.Q1362Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1398	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)														---	---	---	---
GOLGB1	2804	broad.mit.edu	37	3	121417318	121417318	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121417318A>G	uc003eei.3	-	13	2163	c.2037T>C	c.(2035-2037)GGT>GGC	p.G679G	GOLGB1_uc010hrc.2_Silent_p.G684G|GOLGB1_uc003eej.3_Silent_p.G645G|GOLGB1_uc011bjm.1_Silent_p.G565G|GOLGB1_uc010hrd.1_Silent_p.G643G	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	679	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)														---	---	---	---
ILDR1	286676	broad.mit.edu	37	3	121712306	121712306	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121712306T>C	uc003ees.2	-	7	1396	c.1290A>G	c.(1288-1290)GCA>GCG	p.A430A	ILDR1_uc003eeq.2_Silent_p.A398A|ILDR1_uc003eer.2_Silent_p.A386A|ILDR1_uc010hrg.2_Silent_p.A341A	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	430	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)														---	---	---	---
CASR	846	broad.mit.edu	37	3	122003712	122003712	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122003712G>A	uc003eev.3	+	7	3283	c.2911G>A	c.(2911-2913)GGC>AGC	p.G971S	CASR_uc003eew.3_Missense_Mutation_p.G981S	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	971	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)													---	---	---	---
PARP15	165631	broad.mit.edu	37	3	122335917	122335917	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122335917T>C	uc003efm.2	+	6	972	c.906T>C	c.(904-906)GGT>GGC	p.G302G	PARP15_uc003efn.2_Intron|PARP15_uc003efo.1_Silent_p.G49G|PARP15_uc003efp.1_Silent_p.G68G|PARP15_uc011bjt.1_Silent_p.G68G	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	280	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
PARP15	165631	broad.mit.edu	37	3	122345871	122345871	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122345871A>G	uc003efm.2	+	9	1495	c.1429A>G	c.(1429-1431)ATG>GTG	p.M477V	PARP15_uc003efn.2_Intron|PARP15_uc003efo.1_Missense_Mutation_p.M224V|PARP15_uc003efp.1_Missense_Mutation_p.M243V|PARP15_uc011bjt.1_Intron	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	455					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
ADCY5	111	broad.mit.edu	37	3	123021996	123021996	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:123021996T>C	uc003egh.1	-	14	2630	c.2630A>G	c.(2629-2631)AAC>AGC	p.N877S	ADCY5_uc003egg.1_Missense_Mutation_p.N510S|ADCY5_uc003egi.1_Missense_Mutation_p.N436S	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	877	Extracellular (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)														---	---	---	---
KALRN	8997	broad.mit.edu	37	3	124281903	124281903	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124281903G>A	uc003ehg.2	+	34	5270	c.5143G>A	c.(5143-5145)GTG>ATG	p.V1715M	KALRN_uc003ehi.2_Missense_Mutation_p.V88M	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1715					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
ITGB5	3693	broad.mit.edu	37	3	124487942	124487942	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124487942C>T	uc003eho.2	-	12	2232	c.1935G>A	c.(1933-1935)CTG>CTA	p.L645L	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	645	Extracellular (Potential).			L -> P (in Ref. 3; AAA59183).	cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)														---	---	---	---
SLC12A8	84561	broad.mit.edu	37	3	124826845	124826845	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124826845G>A	uc003ehv.3	-	10	1296	c.1185C>T	c.(1183-1185)TAC>TAT	p.Y395Y	SLC12A8_uc003ehw.3_Silent_p.Y424Y|SLC12A8_uc003eht.3_Silent_p.Y196Y|SLC12A8_uc003ehu.3_Silent_p.Y148Y|SLC12A8_uc010hry.2_Silent_p.Y148Y	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	395	Helical; (Potential).				potassium ion transport	integral to membrane	symporter activity				0																		---	---	---	---
SLC12A8	84561	broad.mit.edu	37	3	124906230	124906230	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124906230C>T	uc003ehv.3	-	4	352	c.241G>A	c.(241-243)GTC>ATC	p.V81I	SLC12A8_uc003ehw.3_Missense_Mutation_p.V110I|SLC12A8_uc010hrz.1_5'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	81	Helical; (Potential).				potassium ion transport	integral to membrane	symporter activity				0																		---	---	---	---
CCDC37	348807	broad.mit.edu	37	3	126154470	126154470	+	Missense_Mutation	SNP	G	A	A	rs142534437	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126154470G>A	uc003eiu.1	+	16	1796	c.1697G>A	c.(1696-1698)CGC>CAC	p.R566H	CCDC37_uc010hsg.1_Missense_Mutation_p.R567H	NM_182628	NP_872434	Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	566	Potential.									ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.166)														---	---	---	---
UROC1	131669	broad.mit.edu	37	3	126222903	126222903	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126222903T>C	uc003eiz.1	-	9	869	c.837A>G	c.(835-837)AAA>AAG	p.K279K	UROC1_uc010hsi.1_Silent_p.K279K	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	279					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126733642	126733642	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126733642C>T	uc003ejg.2	+	13	2780	c.2776C>T	c.(2776-2778)CGC>TGC	p.R926C		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	949	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126748346	126748346	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126748346T>C	uc003ejg.2	+	26	4772	c.4768T>C	c.(4768-4770)TCC>CCC	p.S1590P	PLXNA1_uc003ejh.2_Missense_Mutation_p.S258P	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1613	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	126915966	126915966	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126915966C>T	uc003eji.1	+	2	678	c.438C>T	c.(436-438)GGC>GGT	p.G146G						RecName: Full=Putative uncharacterized protein C3orf56;																														---	---	---	---
ACAD9	28976	broad.mit.edu	37	3	128627052	128627052	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128627052T>C	uc003ela.3	+	13	1505	c.1303T>C	c.(1303-1305)TAC>CAC	p.Y435H	ACAD9_uc010hsw.1_Missense_Mutation_p.Y312H|ACAD9_uc011bks.1_Missense_Mutation_p.Y312H|ACAD9_uc003elb.2_Missense_Mutation_p.Y312H|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.Y87H	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	435						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	129129998	129129998	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129129998T>C	uc003emg.2	-							NM_207307	NP_997190			hypothetical protein LOC90288																														---	---	---	---
Unknown	0	broad.mit.edu	37	3	129130176	129130176	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129130176C>T	uc003emg.2	-	5	1023	c.860G>A	c.(859-861)AGA>AAA	p.R287K		NM_207307	NP_997190			hypothetical protein LOC90288																														---	---	---	---
IFT122	55764	broad.mit.edu	37	3	129202433	129202433	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129202433C>T	uc003emm.2	+	15	1965	c.1759C>T	c.(1759-1761)CGG>TGG	p.R587W	IFT122_uc003eml.2_Missense_Mutation_p.R638W|IFT122_uc003emn.2_Missense_Mutation_p.R528W|IFT122_uc003emo.2_Missense_Mutation_p.R476W|IFT122_uc003emp.2_Missense_Mutation_p.R437W|IFT122_uc010htc.2_Missense_Mutation_p.R579W|IFT122_uc011bky.1_Missense_Mutation_p.R378W|IFT122_uc003emq.2_Missense_Mutation_p.R427W|IFT122_uc003emr.2_Missense_Mutation_p.R378W|IFT122_uc011bla.1_Missense_Mutation_p.R378W|IFT122_uc011bkx.1_Missense_Mutation_p.R427W|IFT122_uc011bkz.1_RNA|IFT122_uc010htd.1_Missense_Mutation_p.R66W	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	587					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2																		---	---	---	---
TMCC1	23023	broad.mit.edu	37	3	129370592	129370592	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129370592T>C	uc003emz.3	-	7	2195	c.1694A>G	c.(1693-1695)CAG>CGG	p.Q565R	TMCC1_uc003emy.3_Missense_Mutation_p.Q241R|TMCC1_uc011blc.1_Missense_Mutation_p.Q386R|TMCC1_uc010htg.2_Missense_Mutation_p.Q451R	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	565	Potential.					integral to membrane				skin(1)	1																		---	---	---	---
COL6A6	131873	broad.mit.edu	37	3	130346189	130346189	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130346189T>C	uc010htl.2	+	25	4999	c.4968T>C	c.(4966-4968)GGT>GGC	p.G1656G	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1656	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8																		---	---	---	---
COL6A6	131873	broad.mit.edu	37	3	130394222	130394222	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130394222C>A	uc010htl.2	+	36	6804	c.6773C>A	c.(6772-6774)GCT>GAT	p.A2258D	COL6A6_uc003eni.3_Missense_Mutation_p.A357D	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2258	Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8																		---	---	---	---
ASTE1	28990	broad.mit.edu	37	3	130743233	130743233	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130743233T>C	uc003env.1	-	3	1360	c.918A>G	c.(916-918)CTA>CTG	p.L306L	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Silent_p.L306L|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	306					DNA repair		nuclease activity				0																		---	---	---	---
DNAJC13	23317	broad.mit.edu	37	3	132213065	132213065	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132213065T>C	uc003eor.2	+	34	3968	c.3903T>C	c.(3901-3903)GAT>GAC	p.D1301D		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1301	J.						heat shock protein binding			ovary(1)|breast(1)	2																		---	---	---	---
DNAJC13	23317	broad.mit.edu	37	3	132230098	132230098	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132230098T>C	uc003eor.2	+							NM_015268	NP_056083			DnaJ (Hsp40) homolog, subfamily C, member 13								heat shock protein binding			ovary(1)|breast(1)	2																		---	---	---	---
ACAD11	84129	broad.mit.edu	37	3	132322179	132322179	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:132322179T>C	uc003eov.3	-						ACAD11_uc011blr.1_Intron	NM_032169	NP_115545			putative acyl-CoA dehydrogenase							peroxisome	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|transferase activity, transferring phosphorus-containing groups			ovary(1)	1																		---	---	---	---
BFSP2	8419	broad.mit.edu	37	3	133167397	133167397	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133167397A>G	uc003epn.1	+	3	775	c.637A>G	c.(637-639)ATT>GTT	p.I213V	uc003epo.2_Intron	NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	213	Rod.|Potential.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133356834	133356834	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133356834G>A	uc003eps.2	-	14	2538	c.2406C>T	c.(2404-2406)GTC>GTT	p.V802V		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	802					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133358933	133358933	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133358933A>G	uc003eps.2	-	13	2235	c.2103T>C	c.(2101-2103)GGT>GGC	p.G701G		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	701	BRCT 5.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
TF	7018	broad.mit.edu	37	3	133467417	133467417	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133467417A>G	uc003epu.1	+	7	1933	c.205A>G	c.(205-207)AGG>GGG	p.R69G	TF_uc011bls.1_Missense_Mutation_p.R69G|TF_uc011blt.1_Intron|TF_uc003epw.1_Intron|TF_uc010htv.1_RNA|TF_uc003epv.1_Missense_Mutation_p.R69G	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	69	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)													---	---	---	---
MSL2	55167	broad.mit.edu	37	3	135870304	135870304	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:135870304A>G	uc003eqx.1	-	2	2152	c.1419T>C	c.(1417-1419)GTT>GTC	p.V473V	MSL2_uc011bmb.1_Silent_p.V399V	NM_018133	NP_060603	Q9HCI7	MSL2_HUMAN	ring finger protein 184 isoform 1	473					histone H4-K16 acetylation	MSL complex	zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
STAG1	10274	broad.mit.edu	37	3	136057249	136057249	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136057249T>C	uc003era.1	-	33	4008	c.3716A>G	c.(3715-3717)GAC>GGC	p.D1239G	STAG1_uc003erb.1_Missense_Mutation_p.D1202G	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	1239					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
CLDN18	51208	broad.mit.edu	37	3	137729094	137729094	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:137729094G>A	uc003ero.1	+						CLDN18_uc003erp.1_Silent_p.V9V|CLDN18_uc010hue.1_Missense_Mutation_p.G5S	NM_001002026	NP_001002026			claudin 18 isoform 2						calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ESYT3	83850	broad.mit.edu	37	3	138193080	138193080	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138193080C>T	uc003esk.2	+	20	2580	c.2354C>T	c.(2353-2355)ACC>ATC	p.T785I		NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	785	C2 3.					integral to membrane|plasma membrane					0																		---	---	---	---
FOXL2	668	broad.mit.edu	37	3	138665239	138665239	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138665239T>C	uc003esw.2	-	1	744	c.326A>G	c.(325-327)AAC>AGC	p.N109S	uc003esv.1_5'Flank|C3orf72_uc003esx.1_5'Flank|C3orf72_uc011bmr.1_5'Flank	NM_023067	NP_075555	P58012	FOXL2_HUMAN	forkhead box L2	109	Fork-head.		N -> K (in BPES; type II; diffuse nuclear localization as wild type; impaired transactivation activity).		convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			ovary(266)|large_intestine(1)|skin(1)	268								Mis		granulosa-cell tumour of the ovary		Blepharophimosis|ptosis and epicanthus inversus Types I|II; Premature ovarian failure type III						---	---	---	---
COPB2	9276	broad.mit.edu	37	3	139077910	139077910	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:139077910A>G	uc003etf.3	-	19	2544	c.2414T>C	c.(2413-2415)TTT>TCT	p.F805S	COPB2_uc011bmv.1_Missense_Mutation_p.F776S|COPB2_uc010hui.2_Missense_Mutation_p.F776S	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	805					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2																		---	---	---	---
TRIM42	287015	broad.mit.edu	37	3	140406631	140406631	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140406631G>T	uc003eto.1	+	3	1298	c.1107G>T	c.(1105-1107)AAG>AAT	p.K369N		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	369						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7																		---	---	---	---
RASA2	5922	broad.mit.edu	37	3	141292021	141292021	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141292021T>C	uc003etz.1	+	13	1317	c.1317T>C	c.(1315-1317)GAT>GAC	p.D439D	RASA2_uc010huq.1_Silent_p.D439D|RASA2_uc003eua.1_Silent_p.D439D|RASA2_uc011bnc.1_Silent_p.D31D	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	439	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6																		---	---	---	---
RASA2	5922	broad.mit.edu	37	3	141300007	141300007	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:141300007A>G	uc003etz.1	+	17	1740	c.1740A>G	c.(1738-1740)ATA>ATG	p.I580M	RASA2_uc010huq.1_Missense_Mutation_p.I580M|RASA2_uc003eua.1_Missense_Mutation_p.I580M|RASA2_uc011bnc.1_Missense_Mutation_p.I172M	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	580					intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6																		---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142137699	142137699	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142137699T>C	uc003eus.2	-	11	1265	c.1198A>G	c.(1198-1200)ACT>GCT	p.T400A	XRN1_uc003eut.2_Missense_Mutation_p.T400A|XRN1_uc003euu.2_Missense_Mutation_p.T400A|XRN1_uc003euv.1_Missense_Mutation_p.T261A|XRN1_uc003euw.2_Missense_Mutation_p.T400A|XRN1_uc011bnh.1_Missense_Mutation_p.T190A	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	400					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142423328	142423328	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142423328A>T	uc010huv.2	+	14	1688	c.1529A>T	c.(1528-1530)GAT>GTT	p.D510V	PLS1_uc003euz.2_Missense_Mutation_p.D510V|PLS1_uc003eva.2_Missense_Mutation_p.D510V	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	510	Actin-binding 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
SLC9A9	285195	broad.mit.edu	37	3	142987779	142987779	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142987779T>C	uc003evn.2	-	15	1830	c.1648A>G	c.(1648-1650)ACA>GCA	p.T550A		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	550					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3																		---	---	---	---
PLSCR4	57088	broad.mit.edu	37	3	145914557	145914557	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:145914557A>G	uc010huy.2	-	7	977	c.648T>C	c.(646-648)GGT>GGC	p.G216G	PLSCR4_uc010huz.2_Silent_p.G216G|PLSCR4_uc003evt.3_Silent_p.G216G|PLSCR4_uc010hva.2_Silent_p.G126G|PLSCR4_uc003evu.3_Silent_p.G111G	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	216	Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0																		---	---	---	---
ZIC4	84107	broad.mit.edu	37	3	147120530	147120530	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:147120530T>C	uc003ewd.1	-	2	328	c.55A>G	c.(55-57)ACT>GCT	p.T19A	ZIC4_uc011bno.1_Missense_Mutation_p.T69A	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	19						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2																		---	---	---	---
ZIC1	7545	broad.mit.edu	37	3	147128763	147128763	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:147128763A>G	uc003ewe.2	+	1	1583	c.864A>G	c.(862-864)AAA>AAG	p.K288K		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	288	C2H2-type 2; atypical.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
RNF13	11342	broad.mit.edu	37	3	149589943	149589943	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:149589943T>C	uc003exn.3	+	5	1105	c.321_splice	c.e5+2	p.K107_splice	RNF13_uc003exp.3_Splice_Site_p.K107_splice|RNF13_uc010hvh.2_Splice_Site	NM_007282	NP_009213			ring finger protein 13						protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)															---	---	---	---
P2RY14	9934	broad.mit.edu	37	3	150931733	150931733	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150931733T>C	uc003eyr.1	-	3	850	c.372A>G	c.(370-372)GTA>GTG	p.V124V	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Silent_p.V124V	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	124	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
P2RY13	53829	broad.mit.edu	37	3	151046137	151046137	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151046137T>C	uc003eyv.2	-	2	728	c.707A>G	c.(706-708)TAT>TGT	p.Y236C	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	236	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)															---	---	---	---
MED12L	116931	broad.mit.edu	37	3	151085530	151085530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151085530G>A	uc003eyp.2	+	22	3357	c.3319G>A	c.(3319-3321)GCA>ACA	p.A1107T	MED12L_uc011bnz.1_Missense_Mutation_p.A967T|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.A270T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1107					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
IGSF10	285313	broad.mit.edu	37	3	151155548	151155548	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151155548T>C	uc011bod.1	-	6	6801	c.6801A>G	c.(6799-6801)CCA>CCG	p.P2267P	IGSF10_uc011bob.1_Silent_p.P294P|IGSF10_uc011boc.1_Silent_p.P246P	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2267	Ig-like C2-type 9.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
AADACL2	344752	broad.mit.edu	37	3	151475230	151475230	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151475230A>G	uc003ezc.2	+	5	1174	c.1054A>G	c.(1054-1056)ACA>GCA	p.T352A	AADACL2_uc010hvn.2_Missense_Mutation_p.T139A	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	352						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)															---	---	---	---
SLC33A1	9197	broad.mit.edu	37	3	155560327	155560327	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155560327A>G	uc003fan.3	-	2	1238	c.857T>C	c.(856-858)GTA>GCA	p.V286A	SLC33A1_uc003fao.1_Missense_Mutation_p.V286A	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	286	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
GFM1	85476	broad.mit.edu	37	3	158402330	158402330	+	Silent	SNP	C	T	T	rs141903395		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158402330C>T	uc003fce.2	+	15	1889	c.1782C>T	c.(1780-1782)TGC>TGT	p.C594C	GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Silent_p.C525C	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	594					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)															---	---	---	---
NMD3	51068	broad.mit.edu	37	3	160955951	160955951	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:160955951G>A	uc003feb.1	+	8	747	c.628G>A	c.(628-630)GAA>AAA	p.E210K	NMD3_uc003fec.2_Missense_Mutation_p.E210K|NMD3_uc003fed.1_Missense_Mutation_p.E210K|NMD3_uc010hwh.2_Missense_Mutation_p.E30K	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	210					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)															---	---	---	---
SI	6476	broad.mit.edu	37	3	164700040	164700040	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164700040A>G	uc003fei.2	-	47	5468	c.5406T>C	c.(5404-5406)ACT>ACC	p.T1802T		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1802	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---
SI	6476	broad.mit.edu	37	3	164767648	164767648	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164767648A>G	uc003fei.2	-	14	1590	c.1528T>C	c.(1528-1530)TCC>CCC	p.S510P		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	510	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---
SI	6476	broad.mit.edu	37	3	164777823	164777823	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:164777823T>C	uc003fei.2	-							NM_001041	NP_001032			sucrase-isomaltase						carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)										HNSCC(35;0.089)			---	---	---	---
GOLIM4	27333	broad.mit.edu	37	3	167750468	167750468	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167750468T>C	uc003ffe.2	-	9	1360	c.1016A>G	c.(1015-1017)CAC>CGC	p.H339R	GOLIM4_uc011bpe.1_Missense_Mutation_p.H339R|GOLIM4_uc011bpf.1_Missense_Mutation_p.H311R|GOLIM4_uc011bpg.1_Missense_Mutation_p.H311R	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	339	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5																		---	---	---	---
SLC7A14	57709	broad.mit.edu	37	3	170198305	170198305	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170198305T>C	uc003fgz.2	-	7	2082	c.1766A>G	c.(1765-1767)TAC>TGC	p.Y589C	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	589						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)															---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171405313	171405313	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171405313T>C	uc003fhs.2	-	15	1717	c.1601A>G	c.(1600-1602)AAC>AGC	p.N534S	PLD1_uc003fht.2_Missense_Mutation_p.N534S	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	534	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171406516	171406516	+	Missense_Mutation	SNP	C	T	T	rs149680370		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171406516C>T	uc003fhs.2	-	14	1605	c.1489G>A	c.(1489-1491)GTG>ATG	p.V497M	PLD1_uc003fht.2_Missense_Mutation_p.V497M	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	497	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171406526	171406526	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171406526T>C	uc003fhs.2	-	14	1595	c.1479A>G	c.(1477-1479)AGA>AGG	p.R493R	PLD1_uc003fht.2_Silent_p.R493R	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	493	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171455811	171455811	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171455811T>A	uc003fhs.2	-	2	147	c.31A>T	c.(31-33)ACC>TCC	p.T11S	PLD1_uc003fht.2_Missense_Mutation_p.T11S	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	11					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
FNDC3B	64778	broad.mit.edu	37	3	172065073	172065073	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172065073A>G	uc003fhy.2	+	21	2608	c.2436A>G	c.(2434-2436)GAA>GAG	p.E812E	FNDC3B_uc003fhz.3_Silent_p.E812E	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	812	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)														---	---	---	---
NLGN1	22871	broad.mit.edu	37	3	173322505	173322505	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:173322505G>A	uc003fio.1	+	3	540	c.117G>A	c.(115-117)CAG>CAA	p.Q39Q	NLGN1_uc010hww.1_Silent_p.Q39Q|NLGN1_uc003fip.1_Silent_p.Q39Q	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	39					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)															---	---	---	---
NLGN1	22871	broad.mit.edu	37	3	173998423	173998423	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:173998423A>G	uc003fio.1	+	7	2225	c.1802A>G	c.(1801-1803)AAT>AGT	p.N601S	NLGN1_uc003fip.1_Missense_Mutation_p.N601S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	618	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)															---	---	---	---
NAALADL2	254827	broad.mit.edu	37	3	174814922	174814922	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:174814922T>C	uc003fit.2	+	2	473	c.386T>C	c.(385-387)CTT>CCT	p.L129P	NAALADL2_uc003fiu.1_Missense_Mutation_p.L122P	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	129	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)														---	---	---	---
ZMAT3	64393	broad.mit.edu	37	3	178745553	178745553	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178745553A>G	uc003fjg.2	-	4	697	c.438T>C	c.(436-438)AAT>AAC	p.N146N	ZMAT3_uc010hxa.2_Silent_p.N146N|ZMAT3_uc003fji.2_Silent_p.N146N	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	146					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178916944	178916944	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178916944A>G	uc003fjk.2	+	2	488	c.331A>G	c.(331-333)AAG>GAG	p.K111E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111N(10)|p.K111E(7)|p.K111R(1)|p.K111del(1)|p.K111_I112>N(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178948070	178948070	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178948070A>G	uc003fjk.2	+	20	2999	c.2842A>G	c.(2842-2844)AAA>GAA	p.K948E		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	948	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
MFN1	55669	broad.mit.edu	37	3	179096608	179096608	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179096608T>C	uc003fjs.2	+						MFN1_uc010hxb.2_Intron|MFN1_uc003fjt.2_Intron|MFN1_uc010hxc.2_Intron	NM_033540	NP_284941			mitofusin 1						mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)															---	---	---	---
MRPL47	57129	broad.mit.edu	37	3	179322414	179322414	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179322414T>C	uc003fjz.2	-	1					MRPL47_uc003fka.2_5'UTR|MRPL47_uc003fkb.2_5'UTR|NDUFB5_uc003fkc.2_5'Flank|NDUFB5_uc003fkd.2_5'Flank|NDUFB5_uc003fke.2_5'Flank	NM_020409	NP_065142			mitochondrial ribosomal protein L47 isoform a						translation	mitochondrial ribosome	structural constituent of ribosome				0	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)															---	---	---	---
NDUFB5	4711	broad.mit.edu	37	3	179322596	179322596	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179322596T>C	uc003fkc.2	+	1					MRPL47_uc003fjz.2_5'Flank|MRPL47_uc003fka.2_5'Flank|MRPL47_uc003fkb.2_5'Flank|NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_5'UTR	NM_002492	NP_002483			NADH dehydrogenase (ubiquinone) 1 beta						mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)													---	---	---	---
B3GNT5	84002	broad.mit.edu	37	3	182987868	182987868	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:182987868A>G	uc003flk.2	+	2	812	c.282A>G	c.(280-282)GTA>GTG	p.V94V	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Silent_p.V94V|B3GNT5_uc003flm.2_Silent_p.V94V	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	94	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)															---	---	---	---
KLHL6	89857	broad.mit.edu	37	3	183225901	183225901	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183225901T>C	uc003flr.2	-	3	913	c.855A>G	c.(853-855)CCA>CCG	p.P285P	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Silent_p.P283P	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	285										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)															---	---	---	---
YEATS2	55689	broad.mit.edu	37	3	183508661	183508661	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183508661T>A	uc003fly.2	+	21	3185	c.2990T>A	c.(2989-2991)GTG>GAG	p.V997E	YEATS2_uc003flz.2_Missense_Mutation_p.V76E	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	997					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
ABCF3	55324	broad.mit.edu	37	3	183906155	183906155	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183906155C>T	uc003fmz.2	+	7	929	c.796C>T	c.(796-798)CGG>TGG	p.R266W	ABCF3_uc003fna.2_Missense_Mutation_p.R260W|ABCF3_uc003fnb.2_5'Flank	NM_018358	NP_060828	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20),	266	ABC transporter 1.						ATP binding|ATPase activity			ovary(3)|lung(1)	4	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
PSMD2	5708	broad.mit.edu	37	3	184019697	184019697	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184019697G>A	uc003fnn.1	+	5	575	c.542G>A	c.(541-543)CGG>CAG	p.R181Q	PSMD2_uc011brj.1_Missense_Mutation_p.R22Q|PSMD2_uc011brk.1_Missense_Mutation_p.R51Q	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	181					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)													---	---	---	---
PSMD2	5708	broad.mit.edu	37	3	184020206	184020206	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184020206T>C	uc003fnn.1	+	6	786	c.753T>C	c.(751-753)TGT>TGC	p.C251C	PSMD2_uc011brj.1_Silent_p.C92C|PSMD2_uc011brk.1_Silent_p.C121C	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	251					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)													---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184557512	184557512	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184557512T>C	uc003fpb.1	+	7	678	c.507T>C	c.(505-507)GGT>GGC	p.G169G	VPS8_uc010hyd.1_Silent_p.G169G|VPS8_uc003fpc.1_3'UTR	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	169							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
C3orf70	285382	broad.mit.edu	37	3	184801194	184801194	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184801194A>G	uc003fpd.2	-	2	545	c.354T>C	c.(352-354)CCT>CCC	p.P118P		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	118											0																		---	---	---	---
SENP2	59343	broad.mit.edu	37	3	185316734	185316734	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185316734T>C	uc003fpn.2	+						SENP2_uc011brv.1_Intron|SENP2_uc011brw.1_Intron	NM_021627	NP_067640			SUMO1/sentrin/SMT3 specific protease 2						mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)															---	---	---	---
TRA2B	6434	broad.mit.edu	37	3	185641624	185641624	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185641624A>G	uc003fpv.2	-	4	758	c.482T>C	c.(481-483)TTT>TCT	p.F161S	TRA2B_uc003fpt.2_RNA|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_Missense_Mutation_p.F61S|TRA2B_uc003fpw.2_Missense_Mutation_p.F161S	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	161	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2																		---	---	---	---
ETV5	2119	broad.mit.edu	37	3	185769827	185769827	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185769827T>C	uc003fpz.2	-	12	1550	c.1303A>G	c.(1303-1305)ATG>GTG	p.M435V	ETV5_uc003fpy.2_Missense_Mutation_p.M477V	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	435	ETS.				cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)					T	TMPRSS2|SCL45A3	Prostate 								---	---	---	---
CRYGS	1427	broad.mit.edu	37	3	186256602	186256602	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186256602A>G	uc003fqe.2	-	3	472	c.420T>C	c.(418-420)TAT>TAC	p.Y140Y	CRYGS_uc003fqf.2_Silent_p.Y140Y	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	140	Beta/gamma crystallin 'Greek key' 4.						structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)														---	---	---	---
LEPREL1	55214	broad.mit.edu	37	3	189705372	189705372	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:189705372A>G	uc011bsk.1	-	5	1430	c.1042T>C	c.(1042-1044)TAC>CAC	p.Y348H	LEPREL1_uc003fsg.2_Missense_Mutation_p.Y167H	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	348					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
CLDN16	10686	broad.mit.edu	37	3	190126276	190126276	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:190126276T>C	uc003fsi.2	+	4	834	c.766T>C	c.(766-768)TGC>CGC	p.C256R	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	256	Helical; (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)														---	---	---	---
C3orf59	151963	broad.mit.edu	37	3	192517221	192517221	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:192517221A>G	uc011bsp.1	-	2	751	c.430T>C	c.(430-432)TGC>CGC	p.C144R		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	144											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)														---	---	---	---
ATP13A4	84239	broad.mit.edu	37	3	193183832	193183832	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193183832A>G	uc003ftd.2	-	11	1362	c.1254T>C	c.(1252-1254)TGT>TGC	p.C418C	ATP13A4_uc003fte.1_Silent_p.C418C|ATP13A4_uc011bsr.1_Intron|ATP13A4_uc010hzi.2_RNA|ATP13A4_uc003ftf.3_Silent_p.C124C	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	418	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)														---	---	---	---
ATP13A3	79572	broad.mit.edu	37	3	194140605	194140605	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194140605T>C	uc003fty.3	-						ATP13A3_uc003ftx.3_Intron	NM_024524	NP_078800			ATPase type 13A3						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)														---	---	---	---
LSG1	55341	broad.mit.edu	37	3	194373752	194373752	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194373752T>C	uc003fui.2	-	8	1194	c.879A>G	c.(877-879)TCA>TCG	p.S293S		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	293					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)														---	---	---	---
LSG1	55341	broad.mit.edu	37	3	194387291	194387291	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:194387291A>G	uc003fui.2	-	3	552	c.237T>C	c.(235-237)AAT>AAC	p.N79N		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	79					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)														---	---	---	---
PCYT1A	5130	broad.mit.edu	37	3	195975110	195975110	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195975110T>C	uc003fwg.2	-	5	475	c.302A>G	c.(301-303)AAC>AGC	p.N101S	PCYT1A_uc003fwh.2_Missense_Mutation_p.N101S	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	101	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)													---	---	---	---
UBXN7	26043	broad.mit.edu	37	3	196098870	196098870	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196098870T>A	uc003fwm.3	-	6	587	c.512A>T	c.(511-513)AAC>ATC	p.N171I	UBXN7_uc003fwn.3_Missense_Mutation_p.N23I|UBXN7_uc010iae.2_Missense_Mutation_p.N9I	NM_015562	NP_056377	O94888	UBXN7_HUMAN	UBX domain containing 7	171							protein binding			ovary(2)|pancreas(1)	3																		---	---	---	---
PIGX	54965	broad.mit.edu	37	3	196460765	196460765	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196460765T>C	uc010iaj.2	+	7	981	c.700T>C	c.(700-702)TCC>CCC	p.S234P	PIGX_uc003fwx.3_Missense_Mutation_p.S216P|PIGX_uc011btx.1_RNA	NM_017861	NP_060331	Q8TBF5	PIGX_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	257	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00322)														---	---	---	---
PAK2	5062	broad.mit.edu	37	3	196539109	196539109	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196539109A>G	uc003fwy.3	+	9	1115	c.793A>G	c.(793-795)ACT>GCT	p.T265A		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	265	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)														---	---	---	---
SENP5	205564	broad.mit.edu	37	3	196613083	196613083	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196613083T>C	uc003fwz.3	+	2	1280	c.1031T>C	c.(1030-1032)TTC>TCC	p.F344S	SENP5_uc011bty.1_Missense_Mutation_p.F344S	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	344					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)														---	---	---	---
NCBP2	22916	broad.mit.edu	37	3	196666226	196666226	+	Silent	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196666226A>C	uc003fxd.1	-	2	246	c.156T>G	c.(154-156)ACT>ACG	p.T52T	NCBP2_uc003fxb.1_5'UTR|NCBP2_uc011btz.1_Silent_p.T34T|NCBP2_uc003fxc.1_RNA|NCBP2_uc003fxe.1_Intron|NCBP2_uc003fxf.2_Silent_p.T52T	NM_007362	NP_031388	P52298	NCBP2_HUMAN	nuclear cap binding protein subunit 2, 20kDa	52	RRM.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)														---	---	---	---
MFI2	4241	broad.mit.edu	37	3	196743098	196743098	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196743098T>C	uc003fxk.3	-	8	1156	c.1043A>G	c.(1042-1044)TAC>TGC	p.Y348C		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	348	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)														---	---	---	---
KIAA0226	9711	broad.mit.edu	37	3	197420641	197420641	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197420641C>T	uc003fyc.2	-	11	1914	c.1731G>A	c.(1729-1731)TCG>TCA	p.S577S	KIAA0226_uc003fyd.3_Silent_p.S532S|KIAA0226_uc003fye.1_Silent_p.S284S|KIAA0226_uc003fyf.2_3'UTR	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	577	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)														---	---	---	---
KIAA0226	9711	broad.mit.edu	37	3	197430456	197430456	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197430456T>C	uc003fyc.2	-	5	716	c.533A>G	c.(532-534)AAC>AGC	p.N178S	KIAA0226_uc003fyd.3_Missense_Mutation_p.N118S|KIAA0226_uc003fye.1_5'Flank|KIAA0226_uc003fyf.2_Missense_Mutation_p.N11S|KIAA0226_uc003fyg.2_Missense_Mutation_p.N171S	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	178	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)														---	---	---	---
LMLN	89782	broad.mit.edu	37	3	197701945	197701945	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197701945T>C	uc011buo.1	+	3	370	c.348_splice	c.e3+2	p.K116_splice	LMLN_uc003fyt.2_Splice_Site_p.K64_splice|LMLN_uc010iar.2_Splice_Site_p.K116_splice|LMLN_uc010ias.2_Splice_Site_p.K64_splice|LMLN_uc003fyu.2_Splice_Site	NM_033029	NP_149018			leishmanolysin-like isoform 2						cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)														---	---	---	---
ZNF595	152687	broad.mit.edu	37	4	86073	86073	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:86073A>G	uc003fzv.1	+	5	834	c.678A>G	c.(676-678)AAA>AAG	p.K226K	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_5'UTR	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	226					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)														---	---	---	---
ZNF721	170960	broad.mit.edu	37	4	436007	436007	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:436007T>A	uc003gag.2	-	3	2940	c.2249A>T	c.(2248-2250)GAT>GTT	p.D750V	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.D782V|ZNF721_uc010ibe.2_Missense_Mutation_p.D738V	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	750						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1																		---	---	---	---
MYL5	4636	broad.mit.edu	37	4	671812	671812	+	5'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:671812A>G	uc003gav.2	+	1					MYL5_uc003gat.2_Intron|MYL5_uc003gau.2_Intron	NM_002477	NP_002468			myosin regulatory light chain 5						regulation of muscle contraction	muscle myosin complex	calcium ion binding|structural constituent of muscle				0																		---	---	---	---
GAK	2580	broad.mit.edu	37	4	862361	862361	+	Silent	SNP	G	A	A	rs112202640	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:862361G>A	uc003gbm.3	-	20	2560	c.2361C>T	c.(2359-2361)GAC>GAT	p.D787D	GAK_uc003gbn.3_Silent_p.D708D|GAK_uc010ibk.1_Silent_p.D681D|GAK_uc010ibi.2_5'Flank|GAK_uc010ibj.2_RNA|GAK_uc003gbl.3_Silent_p.D651D	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	787					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)														---	---	---	---
GAK	2580	broad.mit.edu	37	4	870373	870373	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:870373T>A	uc003gbm.3	-	18	2198	c.1999A>T	c.(1999-2001)ATT>TTT	p.I667F	GAK_uc003gbn.3_Missense_Mutation_p.I588F|GAK_uc010ibk.1_Missense_Mutation_p.I561F|GAK_uc003gbl.3_Missense_Mutation_p.I531F	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	667	C2 tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)														---	---	---	---
DGKQ	1609	broad.mit.edu	37	4	954993	954993	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:954993G>T	uc003gbw.2	-						DGKQ_uc010ibn.2_Intron	NM_001347	NP_001338			diacylglycerol kinase, theta						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)															---	---	---	---
CTBP1	1487	broad.mit.edu	37	4	1207327	1207327	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1207327G>A	uc003gcv.1	-	7	1125	c.960C>T	c.(958-960)AGC>AGT	p.S320S	uc003gcs.1_Intron|CTBP1_uc003gct.1_Silent_p.S301S|CTBP1_uc003gcu.1_Silent_p.S309S|CTBP1_uc003gcw.2_5'UTR	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	320	Interaction with GLIS2 2 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)														---	---	---	---
SLBP	7884	broad.mit.edu	37	4	1701386	1701386	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1701386A>G	uc003gdi.1	-	5	499	c.384T>C	c.(382-384)TTT>TTC	p.F128F	SLBP_uc010ibx.1_Silent_p.F135F|SLBP_uc003gdj.1_Silent_p.F108F|SLBP_uc003gdk.1_Silent_p.F89F|SLBP_uc011bvf.1_Silent_p.F93F|SLBP_uc003gdl.1_Silent_p.F45F	NM_006527	NP_006518	Q14493	SLBP_HUMAN	stem-loop (histone) binding protein	128					DNA replication involved in S phase|histone mRNA 3'-end processing|mRNA export from nucleus|regulation of S phase|termination of RNA polymerase II transcription	cytosol|histone pre-mRNA 3'end processing complex|nucleoplasm	histone pre-mRNA DCP binding|histone pre-mRNA stem-loop binding|protein binding				0		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.0055)															---	---	---	---
HAUS3	79441	broad.mit.edu	37	4	2233811	2233811	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2233811T>A	uc003ges.1	-	5	1885	c.1655A>T	c.(1654-1656)GAT>GTT	p.D552V	POLN_uc003ger.2_5'Flank|POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Intron|HAUS3_uc003get.1_Missense_Mutation_p.D552V	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	552					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4																		---	---	---	---
MXD4	10608	broad.mit.edu	37	4	2254185	2254185	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2254185T>C	uc003geu.1	-	4	291	c.259A>G	c.(259-261)ACC>GCC	p.T87A		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	87	Helix-loop-helix motif.				negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0																		---	---	---	---
HTT	3064	broad.mit.edu	37	4	3109036	3109036	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3109036G>A	uc011bvq.1	+	7	784	c.639G>A	c.(637-639)CCG>CCA	p.P213P		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	211	HEAT 1.				establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)														---	---	---	---
HTT	3064	broad.mit.edu	37	4	3190708	3190708	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3190708A>C	uc011bvq.1	+	41	5407	c.5262A>C	c.(5260-5262)TTA>TTC	p.L1754F		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1752					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)														---	---	---	---
HTT	3064	broad.mit.edu	37	4	3219639	3219639	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3219639G>A	uc011bvq.1	+	53	7353	c.7208G>A	c.(7207-7209)CGC>CAC	p.R2403H		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	2401	Nuclear export signal (By similarity).				establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)														---	---	---	---
RGS12	6002	broad.mit.edu	37	4	3319065	3319065	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:3319065T>C	uc003ggw.2	+	2	2072	c.1168T>C	c.(1168-1170)TAC>CAC	p.Y390H	RGS12_uc003ggu.2_Missense_Mutation_p.Y390H|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.Y390H|RGS12_uc003ggx.1_Missense_Mutation_p.Y390H	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	390						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
OTOP1	133060	broad.mit.edu	37	4	4228315	4228315	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:4228315G>A	uc003ghp.1	-	1	307	c.277C>T	c.(277-279)CTG>TTG	p.L93L		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	93	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)														---	---	---	---
STK32B	55351	broad.mit.edu	37	4	5461855	5461855	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5461855G>A	uc003gih.1	+	9	873	c.809G>A	c.(808-810)CGC>CAC	p.R270H	STK32B_uc010ida.1_Missense_Mutation_p.R223H	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	270	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5																OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C4orf6	10141	broad.mit.edu	37	4	5527092	5527092	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5527092A>G	uc003gii.2	+	1	210	c.35A>G	c.(34-36)AAT>AGT	p.N12S		NM_005750	NP_005741	Q99440	CD006_HUMAN	chromosome 4 open reading frame 6	12					nervous system development						0																		---	---	---	---
EVC2	132884	broad.mit.edu	37	4	5578085	5578085	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5578085C>T	uc003gij.2	-	18	3208	c.3154G>A	c.(3154-3156)GCC>ACC	p.A1052T	EVC2_uc011bwb.1_Missense_Mutation_p.A492T|EVC2_uc003gik.2_Missense_Mutation_p.A972T	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1052	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5																		---	---	---	---
EVC	2121	broad.mit.edu	37	4	5731079	5731079	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5731079A>G	uc003gil.1	+	3	530	c.346A>G	c.(346-348)AAG>GAG	p.K116E	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	116					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
CRMP1	1400	broad.mit.edu	37	4	5857879	5857879	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5857879G>A	uc003gip.2	-	5	570	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	CRMP1_uc003gin.1_Nonsense_Mutation_p.Q69*|CRMP1_uc003giq.2_Nonsense_Mutation_p.Q157*|CRMP1_uc003gir.2_Nonsense_Mutation_p.Q152*|CRMP1_uc003gis.2_Nonsense_Mutation_p.Q271*	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	157					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)														---	---	---	---
MAN2B2	23324	broad.mit.edu	37	4	6610923	6610923	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6610923A>G	uc003gjf.1	+	12	1940	c.1904A>G	c.(1903-1905)TAC>TGC	p.Y635C	MAN2B2_uc003gje.1_Missense_Mutation_p.Y635C|MAN2B2_uc011bwf.1_Missense_Mutation_p.Y584C	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	635					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2																		---	---	---	---
CCDC96	257236	broad.mit.edu	37	4	7043037	7043037	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7043037C>T	uc003gjv.2	-	1	1692	c.1629G>A	c.(1627-1629)AGG>AGA	p.R543R	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	543											0																		---	---	---	---
GRPEL1	80273	broad.mit.edu	37	4	7062879	7062879	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7062879T>C	uc003gjy.1	-	4	405	c.364A>G	c.(364-366)ACA>GCA	p.T122A	GRPEL1_uc003gjz.1_3'UTR	NM_025196	NP_079472	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial precursor	122					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding				0																		---	---	---	---
AFAP1	60312	broad.mit.edu	37	4	7795427	7795427	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7795427T>C	uc003gkg.1	-	11	1666	c.1393A>G	c.(1393-1395)ACA>GCA	p.T465A	AFAP1_uc011bwk.1_Missense_Mutation_p.T465A	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	465				T -> A (in Ref. 2; BAF83496).		actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0																		---	---	---	---
SH3TC1	54436	broad.mit.edu	37	4	8229571	8229571	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8229571A>G	uc003gkv.3	+	12	2251	c.2150A>G	c.(2149-2151)TAC>TGC	p.Y717C	SH3TC1_uc003gkw.3_Missense_Mutation_p.Y641C|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	717							binding			large_intestine(2)|pancreas(1)	3																		---	---	---	---
SLC2A9	56606	broad.mit.edu	37	4	9836555	9836555	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:9836555C>T	uc003gmc.2	-	11	1430	c.1369G>A	c.(1369-1371)GTC>ATC	p.V457I	SLC2A9_uc003gmd.2_Missense_Mutation_p.V428I	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	457	Helical; Name=11; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3																		---	---	---	---
ZNF518B	85460	broad.mit.edu	37	4	10445841	10445841	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10445841A>G	uc003gmn.2	-	3	2599	c.2112T>C	c.(2110-2112)TCT>TCC	p.S704S		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	704					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
ZNF518B	85460	broad.mit.edu	37	4	10446888	10446888	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10446888A>G	uc003gmn.2	-	3	1552	c.1065T>C	c.(1063-1065)GGT>GGC	p.G355G		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
BOD1L	259282	broad.mit.edu	37	4	13571645	13571645	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:13571645G>A	uc003gmz.1	-	26	9263	c.9146C>T	c.(9145-9147)GCG>GTG	p.A3049V		NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	3049							DNA binding			ovary(5)|breast(1)	6																		---	---	---	---
BOD1L	259282	broad.mit.edu	37	4	13601895	13601895	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:13601895T>A	uc003gmz.1	-	10	6746	c.6629A>T	c.(6628-6630)AAG>ATG	p.K2210M	BOD1L_uc010idr.1_Missense_Mutation_p.K1547M	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2210							DNA binding			ovary(5)|breast(1)	6																		---	---	---	---
BOD1L	259282	broad.mit.edu	37	4	13602539	13602539	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:13602539T>C	uc003gmz.1	-	10	6102	c.5985A>G	c.(5983-5985)GAA>GAG	p.E1995E	BOD1L_uc010idr.1_Silent_p.E1332E	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1995							DNA binding			ovary(5)|breast(1)	6																		---	---	---	---
CC2D2A	57545	broad.mit.edu	37	4	15511838	15511838	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15511838C>T	uc010idv.2	+	8	760	c.515C>T	c.(514-516)GCA>GTA	p.A172V	CC2D2A_uc003gnx.2_Missense_Mutation_p.A123V|CC2D2A_uc003gnu.2_Missense_Mutation_p.A172V|CC2D2A_uc003gnv.2_Missense_Mutation_p.A172V	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	172					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3																		---	---	---	---
CD38	952	broad.mit.edu	37	4	15780029	15780029	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15780029T>C	uc011bxc.1	+	1					CD38_uc003goj.1_5'UTR|CD38_uc003gol.1_5'UTR	NM_001775	NP_001766			CD38 antigen						B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2																		---	---	---	---
CD38	952	broad.mit.edu	37	4	15780076	15780076	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15780076A>G	uc011bxc.1	+	1	146	c.39A>G	c.(37-39)AAA>AAG	p.K13K	CD38_uc003goj.1_Silent_p.K13K|CD38_uc003gol.1_Silent_p.K13K	NM_001775	NP_001766	P28907	CD38_HUMAN	CD38 antigen	13	Cytoplasmic (Potential).				B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			ovary(2)	2																		---	---	---	---
TAPT1	202018	broad.mit.edu	37	4	16215413	16215413	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:16215413C>T	uc010ied.1	-	2	389	c.308G>A	c.(307-309)CGA>CAA	p.R103Q	TAPT1_uc011bxe.1_Intron|TAPT1_uc003gow.3_Intron	NM_153365	NP_699196	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation	103						integral to membrane	growth hormone-releasing hormone receptor activity				0																		---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22425958	22425958	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22425958A>G	uc003gqm.1	-	11	1726	c.1461T>C	c.(1459-1461)GTT>GTC	p.V487V	GPR125_uc010ieo.1_Silent_p.V361V|GPR125_uc003gqn.1_Silent_p.V261V|GPR125_uc003gqo.2_Silent_p.V487V	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	487	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
GPR125	166647	broad.mit.edu	37	4	22449096	22449096	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22449096C>A	uc003gqm.1	-	5	777	c.512G>T	c.(511-513)GGA>GTA	p.G171V	GPR125_uc010ieo.1_Missense_Mutation_p.G45V|GPR125_uc003gqo.2_Missense_Mutation_p.G171V	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	171	Extracellular (Potential).|LRR 4.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)																---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22729385	22729385	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22729385A>G	uc003gqp.3	+						GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Intron	NM_020973	NP_066024			cytosolic beta-glucosidase isoform a						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
GBA3	57733	broad.mit.edu	37	4	22750561	22750561	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:22750561A>G	uc003gqp.3	+	4	1276	c.1185A>G	c.(1183-1185)CAA>CAG	p.Q395Q	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Silent_p.Q396Q	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	395					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0																		---	---	---	---
CCDC149	91050	broad.mit.edu	37	4	24875302	24875302	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:24875302C>T	uc011bxr.1	-	4	408	c.264_splice	c.e4+1	p.Q88_splice	CCDC149_uc003grc.2_Splice_Site_p.Q88_splice|CCDC149_uc003grb.2_Splice_Site|CCDC149_uc003grd.2_Splice_Site_p.Q88_splice|CCDC149_uc003gre.2_Splice_Site_p.Q33_splice	NM_173463	NP_775734			coiled-coil domain containing 149 isoform 1												0		Breast(46;0.173)																---	---	---	---
SLC34A2	10568	broad.mit.edu	37	4	25671295	25671295	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25671295A>T	uc003grr.2	+	7	743	c.662A>T	c.(661-663)GAC>GTC	p.D221V	SLC34A2_uc003grs.2_Missense_Mutation_p.D220V|SLC34A2_uc010iev.2_Missense_Mutation_p.D220V	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	221	Helical; Name=M3; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)																---	---	---	---
SLC34A2	10568	broad.mit.edu	37	4	25677873	25677873	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25677873T>A	uc003grr.2	+	13	1656	c.1575T>A	c.(1573-1575)TAT>TAA	p.Y525*	SLC34A2_uc003grs.2_Nonsense_Mutation_p.Y524*|SLC34A2_uc010iev.2_Nonsense_Mutation_p.Y524*	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	525	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)																---	---	---	---
SEL1L3	23231	broad.mit.edu	37	4	25806334	25806334	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:25806334C>T	uc003gru.3	-	10	1757	c.1605G>A	c.(1603-1605)GGG>GGA	p.G535G	SEL1L3_uc003grv.2_5'UTR	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	535						integral to membrane	binding				0																		---	---	---	---
PCDH7	5099	broad.mit.edu	37	4	30725028	30725028	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:30725028A>G	uc003gsk.1	+	1	2992	c.1984A>G	c.(1984-1986)ACC>GCC	p.T662A	PCDH7_uc011bxw.1_Missense_Mutation_p.T615A|PCDH7_uc011bxx.1_Missense_Mutation_p.T662A	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	662	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4																		---	---	---	---
TBC1D1	23216	broad.mit.edu	37	4	38023271	38023271	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38023271A>G	uc003gtb.2	+	6	1485	c.1142A>G	c.(1141-1143)AAG>AGG	p.K381R	TBC1D1_uc011byd.1_Missense_Mutation_p.K381R|TBC1D1_uc010ifd.2_Missense_Mutation_p.K128R|TBC1D1_uc011byf.1_Missense_Mutation_p.K252R	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	381	PID.					nucleus	Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39314558	39314558	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39314558A>C	uc003gty.1	-						RFC1_uc003gtx.1_Intron	NM_002913	NP_002904			replication factor C large subunit						DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
KLB	152831	broad.mit.edu	37	4	39409016	39409016	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39409016T>C	uc003gua.2	+	1	544	c.447T>C	c.(445-447)TAT>TAC	p.Y149Y	KLB_uc011byj.1_Silent_p.Y149Y	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	149	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1																		---	---	---	---
UBE2K	3093	broad.mit.edu	37	4	39779998	39779998	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39779998T>G	uc003guu.3	+	7	831	c.547T>G	c.(547-549)TTG>GTG	p.L183V	UBE2K_uc003gus.3_Missense_Mutation_p.L140V|UBE2K_uc003gut.3_Missense_Mutation_p.L132V|UBE2K_uc010ifn.2_RNA|UBE2K_uc011byq.1_Missense_Mutation_p.L122V|UBE2K_uc003guq.3_Missense_Mutation_p.L80V	NM_005339	NP_005330	P61086	UBE2K_HUMAN	ubiquitin-conjugating enzyme E2K isoform 1	183	UBA.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1																		---	---	---	---
PDS5A	23244	broad.mit.edu	37	4	39899999	39899999	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39899999A>G	uc003guv.3	-						PDS5A_uc010ifo.2_Intron|PDS5A_uc003guw.3_Missense_Mutation_p.S594P	NM_001100399	NP_001093869			PDS5, regulator of cohesion maintenance, homolog						cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0																		---	---	---	---
N4BP2	55728	broad.mit.edu	37	4	40122482	40122482	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40122482A>G	uc003guy.3	+	9	3089	c.2751A>G	c.(2749-2751)AAA>AAG	p.K917K	N4BP2_uc010ifq.2_Silent_p.K837K|N4BP2_uc010ifr.2_Silent_p.K837K	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	917						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8																		---	---	---	---
CHRNA9	55584	broad.mit.edu	37	4	40356386	40356386	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40356386A>G	uc003gva.1	+	5	1305	c.1289A>G	c.(1288-1290)TAC>TGC	p.Y430C		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	430	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)													---	---	---	---
BEND4	389206	broad.mit.edu	37	4	42119623	42119623	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42119623T>C	uc003gwn.2	-	6	2097	c.1517A>G	c.(1516-1518)AAC>AGC	p.N506S	BEND4_uc003gwm.2_3'UTR	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	506											0																		---	---	---	---
GRXCR1	389207	broad.mit.edu	37	4	42895333	42895333	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42895333G>T	uc003gwt.2	+	1	50	c.50G>T	c.(49-51)CGG>CTG	p.R17L		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	17					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1																		---	---	---	---
YIPF7	285525	broad.mit.edu	37	4	44638028	44638028	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:44638028C>T	uc010ifx.1	-	3	280	c.263G>A	c.(262-264)GGA>GAA	p.G88E	YIPF7_uc010ify.1_Missense_Mutation_p.G88E	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	88						endoplasmic reticulum membrane|integral to membrane					0																		---	---	---	---
GNPDA2	132789	broad.mit.edu	37	4	44724091	44724091	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:44724091A>G	uc003gwy.2	-						GNPDA2_uc010iga.2_Intron|GNPDA2_uc011bzb.1_Intron|GNPDA2_uc003gwz.1_Intron	NM_138335	NP_612208			glucosamine-6-phosphate deaminase 2						N-acetylglucosamine metabolic process	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			ovary(1)	1																		---	---	---	---
NIPAL1	152519	broad.mit.edu	37	4	48036924	48036924	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48036924A>G	uc003gxw.2	+	5	554	c.488A>G	c.(487-489)AAC>AGC	p.N163S		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	163	Cytoplasmic (Potential).					integral to membrane					0																		---	---	---	---
TEC	7006	broad.mit.edu	37	4	48173385	48173385	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48173385C>A	uc003gxz.2	-	4	416	c.325G>T	c.(325-327)GAA>TAA	p.E109*		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	109	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9																		---	---	---	---
SLAIN2	57606	broad.mit.edu	37	4	48384952	48384952	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48384952A>G	uc003gya.3	+						SLAIN2_uc003gyb.1_Intron	NM_020846	NP_065897			SLAIN motif family, member 2							centrosome					0																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48530056	48530056	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48530056T>C	uc003gyh.1	-	52	7677	c.7072A>G	c.(7072-7074)ACA>GCA	p.T2358A	FRYL_uc003gyg.1_Missense_Mutation_p.T1054A|FRYL_uc003gyi.1_Missense_Mutation_p.T1246A|FRYL_uc003gyj.1_Missense_Mutation_p.T653A	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2358					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48563635	48563635	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48563635A>G	uc003gyh.1	-	33	4320	c.3715T>C	c.(3715-3717)TTT>CTT	p.F1239L	FRYL_uc003gyk.2_Missense_Mutation_p.F1239L|FRYL_uc003gyi.1_Missense_Mutation_p.F128L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1239					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
CWH43	80157	broad.mit.edu	37	4	48990684	48990684	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48990684T>C	uc003gyv.2	+	2	416	c.234T>C	c.(232-234)ATT>ATC	p.I78I	CWH43_uc011bzl.1_Silent_p.I51I	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	78					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
CWH43	80157	broad.mit.edu	37	4	49046852	49046852	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:49046852G>A	uc003gyv.2	+	14	2035	c.1853G>A	c.(1852-1854)CGA>CAA	p.R618Q	CWH43_uc011bzl.1_Missense_Mutation_p.R591Q	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	618	Required for function in lipid remodeling (By similarity).				GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
USP46	64854	broad.mit.edu	37	4	53468063	53468063	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:53468063G>A	uc003gzn.2	-	7	1065	c.880C>T	c.(880-882)CGC>TGC	p.R294C	USP46_uc003gzm.3_Missense_Mutation_p.R287C|USP46_uc011bzr.1_Missense_Mutation_p.R271C|USP46_uc011bzs.1_Missense_Mutation_p.R178C	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	294					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)															---	---	---	---
SCFD2	152579	broad.mit.edu	37	4	54231560	54231560	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54231560A>G	uc003gzu.2	-	1	683	c.549T>C	c.(547-549)GAT>GAC	p.D183D	SCFD2_uc010igm.2_Silent_p.D183D	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	183					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)															---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	54245411	54245411	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54245411G>A	uc003haa.2	+	3	336	c.150G>A	c.(148-150)AGG>AGA	p.R50R	FIP1L1_uc003gzx.3_Silent_p.R35R|FIP1L1_uc011bzt.1_Silent_p.R50R|FIP1L1_uc003gzy.2_Silent_p.R50R|FIP1L1_uc011bzu.1_Silent_p.R35R|FIP1L1_uc003gzz.2_Silent_p.R35R|FIP1L1_uc003hab.2_Silent_p.R38R	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	54373643	54373643	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54373643A>G	uc003haa.2	+						LNX1_uc003haf.3_Intron|LNX1_uc003hag.3_Intron|LNX1_uc003hah.3_Intron	NM_006206	NP_006197			platelet-derived growth factor receptor alpha						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
SRD5A3	79644	broad.mit.edu	37	4	56236243	56236243	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56236243A>G	uc003hau.2	+	5	1037	c.942A>G	c.(940-942)CTA>CTG	p.L314L	uc003hav.1_Intron|uc003haw.1_Intron	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	314	Cytoplasmic (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)															---	---	---	---
EXOC1	55763	broad.mit.edu	37	4	56763012	56763012	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56763012C>T	uc003hbe.1	+	16	2241	c.2083C>T	c.(2083-2085)CGT>TGT	p.R695C	EXOC1_uc003hbf.1_Missense_Mutation_p.R695C|EXOC1_uc003hbg.1_Missense_Mutation_p.R680C	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	695					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
CEP135	9662	broad.mit.edu	37	4	56841097	56841097	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:56841097G>A	uc003hbi.2	+	11	1669	c.1435G>A	c.(1435-1437)GCA>ACA	p.A479T	CEP135_uc003hbj.2_Missense_Mutation_p.A185T	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	479	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
AASDH	132949	broad.mit.edu	37	4	57220334	57220334	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57220334T>C	uc003hbn.2	-	8	1407	c.1254A>G	c.(1252-1254)GTA>GTG	p.V418V	AASDH_uc010ihb.2_5'UTR|AASDH_uc011caa.1_Silent_p.V265V|AASDH_uc003hbo.2_Silent_p.V318V|AASDH_uc011cab.1_Intron|AASDH_uc010ihc.2_Silent_p.V418V|AASDH_uc003hbp.2_Silent_p.V418V	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	418					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)																---	---	---	---
REST	5978	broad.mit.edu	37	4	57777024	57777024	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57777024G>A	uc003hch.2	+	2	567	c.220G>A	c.(220-222)GCA>ACA	p.A74T	REST_uc003hci.2_Missense_Mutation_p.A74T|REST_uc003hcj.1_Missense_Mutation_p.A74T|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	74	Interaction with SIN3A.				cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)																	---	---	---	---
REST	5978	broad.mit.edu	37	4	57777250	57777250	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57777250A>G	uc003hch.2	+	2	793	c.446A>G	c.(445-447)GAC>GGC	p.D149G	REST_uc003hci.2_Missense_Mutation_p.D149G|REST_uc003hcj.1_Missense_Mutation_p.D149G|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	149					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)																	---	---	---	---
LPHN3	23284	broad.mit.edu	37	4	62758502	62758502	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:62758502A>G	uc010ihh.2	+	7	1578	c.1405A>G	c.(1405-1407)ACC>GCC	p.T469A	LPHN3_uc003hcq.3_Missense_Mutation_p.T469A|LPHN3_uc003hcs.1_Missense_Mutation_p.T298A	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	469	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18																		---	---	---	---
EPHA5	2044	broad.mit.edu	37	4	66197715	66197715	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:66197715T>G	uc003hcy.2	-	17	3177	c.2984A>C	c.(2983-2985)GAC>GCC	p.D995A	EPHA5_uc003hcx.2_Missense_Mutation_p.D927A|EPHA5_uc003hcz.2_Missense_Mutation_p.D973A|EPHA5_uc011cah.1_Missense_Mutation_p.D996A|EPHA5_uc011cai.1_Missense_Mutation_p.D974A|EPHA5_uc003hda.2_Missense_Mutation_p.D996A	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	995	Cytoplasmic (Potential).|SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24															TSP Lung(17;0.13)			---	---	---	---
YTHDC1	91746	broad.mit.edu	37	4	69202829	69202829	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69202829G>A	uc003hdx.2	-	4	1152	c.799C>T	c.(799-801)CGA>TGA	p.R267*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.R267*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	267										upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	69343161	69343161	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69343161G>A	uc003hdz.3	+	8	846	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_014058	NP_054777			transmembrane protease, serine 11E																														---	---	---	---
UGT2B10	7365	broad.mit.edu	37	4	69682128	69682128	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69682128T>C	uc003hee.2	+	1	416	c.391T>C	c.(391-393)TCA>CCA	p.S131P	UGT2B10_uc011cam.1_Missense_Mutation_p.S131P	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	131					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5																		---	---	---	---
UGT2B10	7365	broad.mit.edu	37	4	69696589	69696589	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69696589A>G	uc003hee.2	+	6	1604	c.1579A>G	c.(1579-1581)AGG>GGG	p.R527G	UGT2B10_uc011cam.1_Missense_Mutation_p.R443G	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	527					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5																		---	---	---	---
UGT2A3	79799	broad.mit.edu	37	4	69817054	69817054	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69817054T>C	uc003hef.2	-	1	456	c.425A>G	c.(424-426)AAC>AGC	p.N142S	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	142	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
C4orf35	85438	broad.mit.edu	37	4	71201539	71201539	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71201539T>C	uc003hff.2	+	1	869	c.783T>C	c.(781-783)GAT>GAC	p.D261D		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	261						flagellum	calcium ion binding				0		all_hematologic(202;0.196)																---	---	---	---
MUC7	4589	broad.mit.edu	37	4	71346984	71346984	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71346984A>G	uc011cat.1	+	4	811	c.523A>G	c.(523-525)ACT>GCT	p.T175A	MUC7_uc011cau.1_Missense_Mutation_p.T175A|MUC7_uc003hfj.2_Missense_Mutation_p.T175A|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	175	1.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)															---	---	---	---
ADAMTS3	9508	broad.mit.edu	37	4	73205379	73205379	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73205379A>G	uc003hgk.1	-	5	730	c.693T>C	c.(691-693)GGT>GGC	p.G231G		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	231					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	73950955	73950955	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73950955A>G	uc003hgp.2	-						ANKRD17_uc003hgo.2_Intron|ANKRD17_uc003hgq.2_Intron|ANKRD17_uc003hgr.2_Intron	NM_032217	NP_115593			ankyrin repeat domain protein 17 isoform a						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	73981536	73981536	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73981536A>G	uc003hgp.2	-	23	4401	c.4284_splice	c.e23+1	p.K1428_splice	ANKRD17_uc003hgo.2_Splice_Site_p.K1315_splice|ANKRD17_uc003hgq.2_Splice_Site_p.K1177_splice|ANKRD17_uc003hgr.2_Splice_Site_p.K1427_splice|ANKRD17_uc011cbd.1_Splice_Site_p.K993_splice	NM_032217	NP_115593			ankyrin repeat domain protein 17 isoform a						interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	74008406	74008406	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74008406A>G	uc003hgp.2	-	12	2153	c.2036T>C	c.(2035-2037)GTG>GCG	p.V679A	ANKRD17_uc003hgo.2_Missense_Mutation_p.V566A|ANKRD17_uc003hgq.2_Missense_Mutation_p.V679A|ANKRD17_uc003hgr.2_Missense_Mutation_p.V679A|ANKRD17_uc011cbd.1_Missense_Mutation_p.V244A	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	679	ANK 14.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
ALB	213	broad.mit.edu	37	4	74279175	74279175	+	Silent	SNP	G	A	A	rs143665140		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:74279175G>A	uc003hgs.3	+	8	955	c.882G>A	c.(880-882)TCG>TCA	p.S294S	ALB_uc003hgw.3_Silent_p.S102S|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Silent_p.S294S|ALB_uc010iii.2_Silent_p.S179S|ALB_uc003hgu.3_Silent_p.S144S|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Silent_p.S184S|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	294	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)													---	---	---	---
CDKL2	8999	broad.mit.edu	37	4	76551133	76551133	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76551133T>C	uc003hiq.2	-	2	565	c.40A>G	c.(40-42)AGT>GGT	p.S14G	CDKL2_uc011cbp.1_Missense_Mutation_p.S14G|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	14	ATP (By similarity).|Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)															---	---	---	---
G3BP2	9908	broad.mit.edu	37	4	76570767	76570767	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76570767T>C	uc003hir.2	-	12	1461	c.1296A>G	c.(1294-1296)CGA>CGG	p.R432R	G3BP2_uc003his.2_Silent_p.R432R|G3BP2_uc003hit.2_Silent_p.R399R	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	432	Gly-rich.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)															---	---	---	---
SHROOM3	57619	broad.mit.edu	37	4	77661944	77661944	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77661944A>G	uc011cbx.1	+	5	3571	c.2618A>G	c.(2617-2619)GAC>GGC	p.D873G	SHROOM3_uc011cbz.1_Missense_Mutation_p.D697G|SHROOM3_uc003hkf.1_Missense_Mutation_p.D748G|SHROOM3_uc003hkg.2_Missense_Mutation_p.D651G	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	873					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)															---	---	---	---
ANKRD56	345079	broad.mit.edu	37	4	77817393	77817393	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77817393G>A	uc003hki.2	-	1	1610	c.1610C>T	c.(1609-1611)ACG>ATG	p.T537M		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	537											0																		---	---	---	---
FRAS1	80144	broad.mit.edu	37	4	79205664	79205664	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79205664G>A	uc003hlb.2	+	13	1801	c.1361G>A	c.(1360-1362)TGT>TAT	p.C454Y	FRAS1_uc003hkw.2_Missense_Mutation_p.C454Y|FRAS1_uc003hky.1_Missense_Mutation_p.C158Y|FRAS1_uc003hkz.2_Missense_Mutation_p.C158Y|FRAS1_uc003hla.1_5'Flank	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	454	FU 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5																		---	---	---	---
NAA11	84779	broad.mit.edu	37	4	80246583	80246583	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:80246583T>A	uc003hlt.3	-	1	589	c.449A>T	c.(448-450)GAT>GTT	p.D150V		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	150	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SCD5	79966	broad.mit.edu	37	4	83557734	83557734	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83557734C>T	uc003hna.2	-							NM_001037582	NP_001032671			stearoyl-CoA desaturase 5 isoform a						fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)																---	---	---	---
SEC31A	22872	broad.mit.edu	37	4	83765642	83765642	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83765642C>T	uc003hnf.2	-	21	2687	c.2523G>A	c.(2521-2523)CCG>CCA	p.P841P	SEC31A_uc003hnd.2_5'UTR|SEC31A_uc003hne.2_Silent_p.P605P|SEC31A_uc011ccl.1_Silent_p.P802P|SEC31A_uc003hnl.2_Silent_p.P802P|SEC31A_uc003hng.2_Silent_p.P841P|SEC31A_uc003hnh.2_Silent_p.P841P|SEC31A_uc003hni.2_Silent_p.P841P|SEC31A_uc003hnj.2_Silent_p.P802P|SEC31A_uc011ccm.1_Silent_p.P836P|SEC31A_uc011ccn.1_Silent_p.P841P|SEC31A_uc003hnk.2_Silent_p.P802P|SEC31A_uc003hnm.2_Silent_p.P841P|SEC31A_uc003hnn.1_Silent_p.P841P	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	841	Interaction with PDCD6.|Pro-rich.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)																---	---	---	---
CDS1	1040	broad.mit.edu	37	4	85553014	85553014	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85553014G>A	uc011ccv.1	+	6	1121	c.623G>A	c.(622-624)CGT>CAT	p.R208H	CDS1_uc010ike.1_Missense_Mutation_p.R12H	NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	208					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)														---	---	---	---
CDS1	1040	broad.mit.edu	37	4	85569713	85569713	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85569713C>T	uc011ccv.1	+	13	1758	c.1260C>T	c.(1258-1260)GGC>GGT	p.G420G		NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	420					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85660161	85660161	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85660161A>G	uc003hpd.2	-	40	6982	c.6574_splice	c.e40+1	p.G2192_splice		NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85672710	85672710	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85672710G>A	uc003hpd.2	-	36	6307	c.5899C>T	c.(5899-5901)CGG>TGG	p.R1967W		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1967						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85694043	85694043	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85694043C>T	uc003hpd.2	-	30	5202	c.4794G>A	c.(4792-4794)GCG>GCA	p.A1598A		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1598						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85731422	85731422	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85731422T>C	uc003hpd.2	-	14	2371	c.1963A>G	c.(1963-1965)ACA>GCA	p.T655A	WDFY3_uc003hpf.2_Missense_Mutation_p.T655A	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	655						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
MAPK10	5602	broad.mit.edu	37	4	86989018	86989018	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:86989018A>G	uc003hpq.2	-	9	960	c.893T>C	c.(892-894)GTG>GCG	p.V298A	MAPK10_uc010ikg.2_Missense_Mutation_p.V260A|MAPK10_uc003hpr.2_Missense_Mutation_p.V260A|MAPK10_uc003hps.2_Missense_Mutation_p.V298A|MAPK10_uc003hpt.2_Missense_Mutation_p.V298A|MAPK10_uc003hpu.2_Missense_Mutation_p.V298A|MAPK10_uc003hpv.2_Missense_Mutation_p.V153A|MAPK10_uc003hpn.2_Missense_Mutation_p.V46A|MAPK10_uc003hpo.2_Missense_Mutation_p.V153A|MAPK10_uc011ccw.1_Missense_Mutation_p.V184A|MAPK10_uc003hpp.2_Missense_Mutation_p.V153A	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	298	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87638237	87638237	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87638237A>G	uc003hpz.2	+	9	1832	c.1352A>G	c.(1351-1353)GAA>GGA	p.E451G	PTPN13_uc003hpy.2_Missense_Mutation_p.E451G|PTPN13_uc003hqa.2_Missense_Mutation_p.E451G|PTPN13_uc003hqb.2_Missense_Mutation_p.E451G	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	451						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87672210	87672210	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87672210T>C	uc003hpz.2	+	19	3579	c.3099T>C	c.(3097-3099)AGT>AGC	p.S1033S	PTPN13_uc003hpy.2_Silent_p.S1033S|PTPN13_uc003hqa.2_Silent_p.S1033S|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1033						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87679930	87679930	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87679930T>C	uc003hpz.2	+	22	3893	c.3413T>C	c.(3412-3414)TTG>TCG	p.L1138S	PTPN13_uc003hpy.2_Missense_Mutation_p.L1138S|PTPN13_uc003hqa.2_Missense_Mutation_p.L1119S|PTPN13_uc003hqb.2_Missense_Mutation_p.L947S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1138	PDZ 1.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
KLHL8	57563	broad.mit.edu	37	4	88099686	88099686	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88099686A>G	uc011cdb.1	-	5	1424	c.1039T>C	c.(1039-1041)TTC>CTC	p.F347L	KLHL8_uc003hql.1_Missense_Mutation_p.F347L|KLHL8_uc003hqm.1_Missense_Mutation_p.F271L|KLHL8_uc003hqn.1_Missense_Mutation_p.F164L|KLHL8_uc010ikj.1_5'UTR	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	347	Kelch 1.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)														---	---	---	---
NUDT9	53343	broad.mit.edu	37	4	88363012	88363012	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88363012C>T	uc003hqq.2	+	4	798	c.475C>T	c.(475-477)CGG>TGG	p.R159W	NUDT9_uc003hqr.2_Missense_Mutation_p.R109W|NUDT9_uc010ikl.2_Missense_Mutation_p.R127W	NM_024047	NP_076952	Q9BW91	NUDT9_HUMAN	nudix-type motif 9 isoform a	159						mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)														---	---	---	---
NUDT9	53343	broad.mit.edu	37	4	88375511	88375511	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88375511T>C	uc003hqq.2	+						NUDT9_uc003hqr.2_Intron|NUDT9_uc010ikl.2_Intron	NM_024047	NP_076952			nudix-type motif 9 isoform a							mitochondrion	ADP-ribose diphosphatase activity				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000937)														---	---	---	---
SPARCL1	8404	broad.mit.edu	37	4	88414912	88414912	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88414912T>C	uc010ikm.2	-	5	1612	c.1040A>G	c.(1039-1041)GAT>GGT	p.D347G	SPARCL1_uc011cdc.1_Missense_Mutation_p.D222G|SPARCL1_uc003hqs.3_Missense_Mutation_p.D347G|SPARCL1_uc011cdd.1_Missense_Mutation_p.D222G|SPARCL1_uc003hqt.2_Missense_Mutation_p.D347G	NM_001128310	NP_001121782	Q14515	SPRL1_HUMAN	SPARC-like 1 precursor	347					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)														---	---	---	---
HERC5	51191	broad.mit.edu	37	4	89425424	89425424	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89425424A>G	uc003hrt.2	+	21	2777	c.2624A>G	c.(2623-2625)GAC>GGC	p.D875G	HERC5_uc011cdm.1_Missense_Mutation_p.D513G	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	875	HECT.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)														---	---	---	---
HERC3	8916	broad.mit.edu	37	4	89608434	89608434	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89608434G>A	uc003hrw.1	+	23	2807	c.2641G>A	c.(2641-2643)GTG>ATG	p.V881M	HERC3_uc011cdn.1_Missense_Mutation_p.V763M|HERC3_uc011cdo.1_Missense_Mutation_p.V325M	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	881					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)														---	---	---	---
GPRIN3	285513	broad.mit.edu	37	4	90169014	90169014	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90169014G>A	uc003hsm.1	-	2	2767	c.2248C>T	c.(2248-2250)CAC>TAC	p.H750Y		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	750										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)														---	---	---	---
GPRIN3	285513	broad.mit.edu	37	4	90171194	90171194	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90171194T>C	uc003hsm.1	-	2	587	c.68A>G	c.(67-69)GAC>GGC	p.D23G		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	23										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)														---	---	---	---
MMRN1	22915	broad.mit.edu	37	4	90816310	90816310	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90816310C>T	uc003hst.2	+	1	259	c.188C>T	c.(187-189)GCG>GTG	p.A63V	MMRN1_uc010iku.2_Missense_Mutation_p.A63V	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	63					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)														---	---	---	---
MMRN1	22915	broad.mit.edu	37	4	90849013	90849013	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:90849013G>A	uc003hst.2	+	5	1094	c.1023G>A	c.(1021-1023)AAG>AAA	p.K341K	MMRN1_uc010iku.2_Silent_p.K307K|MMRN1_uc011cds.1_Silent_p.K83K	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	341	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)														---	---	---	---
FAM190A	401145	broad.mit.edu	37	4	91230144	91230144	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:91230144C>T	uc003hsv.3	+	2	1049	c.709C>T	c.(709-711)CGG>TGG	p.R237W	FAM190A_uc003hsu.3_Missense_Mutation_p.R237W|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.R237W	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	237										large_intestine(1)|ovary(1)	2																		---	---	---	---
GRID2	2895	broad.mit.edu	37	4	94436447	94436447	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94436447T>C	uc011cdt.1	+	13	2336	c.2078T>C	c.(2077-2079)ATG>ACG	p.M693T	GRID2_uc011cdu.1_Missense_Mutation_p.M598T	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	693	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)													---	---	---	---
GRID2	2895	broad.mit.edu	37	4	94436498	94436498	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94436498G>A	uc011cdt.1	+	13	2387	c.2129G>A	c.(2128-2130)CGG>CAG	p.R710Q	GRID2_uc011cdu.1_Missense_Mutation_p.R615Q	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	710	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)													---	---	---	---
ATOH1	474	broad.mit.edu	37	4	94750593	94750593	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:94750593G>A	uc003hta.1	+	1	516	c.516G>A	c.(514-516)ATG>ATA	p.M172I		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	172	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)														---	---	---	---
HPGDS	27306	broad.mit.edu	37	4	95220654	95220654	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95220654G>A	uc003hte.1	-	6	668	c.577C>T	c.(577-579)CGA>TGA	p.R193*		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	193	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)													---	---	---	---
HPGDS	27306	broad.mit.edu	37	4	95220656	95220656	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95220656T>C	uc003hte.1	-	6	666	c.575A>G	c.(574-576)AAA>AGA	p.K192R		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	192	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)													---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95506156	95506156	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95506156T>C	uc003hti.2	+						PDLIM5_uc003htf.2_Splice_Site_p.R114_splice|PDLIM5_uc003htg.2_Splice_Site_p.R134_splice|PDLIM5_uc011cdx.1_Splice_Site_p.R134_splice|PDLIM5_uc003hth.2_Intron|PDLIM5_uc003htj.2_Intron|PDLIM5_uc003htk.2_Splice_Site_p.R134_splice|PDLIM5_uc011cdy.1_Intron|PDLIM5_uc003htl.2_Splice_Site	NM_006457	NP_006448			PDZ and LIM domain 5 isoform a						regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
PDLIM5	10611	broad.mit.edu	37	4	95561578	95561578	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:95561578C>T	uc003hti.2	+	9	1411	c.1260C>T	c.(1258-1260)TGC>TGT	p.C420C	PDLIM5_uc011cdx.1_Silent_p.C317C|PDLIM5_uc003hth.2_Silent_p.C311C|PDLIM5_uc003htj.2_Silent_p.C95C|PDLIM5_uc003htk.2_Silent_p.C449C|PDLIM5_uc011cdy.1_Silent_p.C298C|PDLIM5_uc003htl.2_Silent_p.C95C	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	420	LIM zinc-binding 1.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)														---	---	---	---
ADH4	127	broad.mit.edu	37	4	100052676	100052676	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100052676A>G	uc003hun.2	-	6	898	c.822T>C	c.(820-822)TGT>TGC	p.C274C	uc003hum.1_Intron|ADH4_uc011ced.1_Silent_p.C293C	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	274					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)													---	---	---	---
ADH6	130	broad.mit.edu	37	4	100128683	100128683	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100128683A>G	uc003hup.3	-	7	978	c.884T>C	c.(883-885)GTG>GCG	p.V295A	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.V295A|ADH6_uc011cef.1_Missense_Mutation_p.V86A|ADH6_uc010ile.2_Intron	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	295	NAD (By similarity).				ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)													---	---	---	---
ADH6	130	broad.mit.edu	37	4	100131424	100131424	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100131424T>C	uc003hup.3	-	5	476	c.382A>G	c.(382-384)ACC>GCC	p.T128A	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.T128A|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Missense_Mutation_p.T128A	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	128					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)													---	---	---	---
RG9MTD2	93587	broad.mit.edu	37	4	100479326	100479326	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100479326T>C	uc003huy.2	-	3	541	c.228A>G	c.(226-228)CGA>CGG	p.R76R	RG9MTD2_uc003huz.3_Silent_p.R76R|RG9MTD2_uc003hva.3_Silent_p.R76R	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	76	Potential.						methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)														---	---	---	---
DNAJB14	79982	broad.mit.edu	37	4	100844195	100844195	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100844195A>G	uc003hvl.2	-	3	602	c.451_splice	c.e3+1	p.K151_splice	DNAJB14_uc003hvk.2_Splice_Site_p.K66_splice|DNAJB14_uc010ili.2_Splice_Site_p.K84_splice	NM_001031723	NP_001026893			DnaJ (Hsp40) homolog, subfamily B, member 14						protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)														---	---	---	---
DDIT4L	115265	broad.mit.edu	37	4	101111136	101111136	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101111136A>G	uc003hvq.2	-	2	208	c.5T>C	c.(4-6)GTT>GCT	p.V2A		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	2					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)														---	---	---	---
CENPE	1062	broad.mit.edu	37	4	104104378	104104378	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104104378T>C	uc003hxb.1	-	10	903	c.813A>G	c.(811-813)AAA>AAG	p.K271K	CENPE_uc003hxc.1_Silent_p.K271K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	271	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)														---	---	---	---
TET2	54790	broad.mit.edu	37	4	106156249	106156249	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106156249A>G	uc003hxk.2	+	3	1536	c.1150A>G	c.(1150-1152)AGC>GGC	p.S384G	TET2_uc011cez.1_Missense_Mutation_p.S405G|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.S384G|TET2_uc003hxi.1_Missense_Mutation_p.S384G	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	384					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)				Mis N|F		MDS								---	---	---	---
NPNT	255743	broad.mit.edu	37	4	106848587	106848587	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106848587T>C	uc003hya.2	+	3	470	c.265_splice	c.e3+2	p.D89_splice	NPNT_uc011cfc.1_Splice_Site_p.D106_splice|NPNT_uc011cfd.1_Splice_Site_p.D89_splice|NPNT_uc011cfe.1_Splice_Site_p.D89_splice|NPNT_uc010ilt.1_Splice_Site_p.D89_splice|NPNT_uc011cff.1_Splice_Site_p.D89_splice|NPNT_uc010ilu.1_Splice_Site	NM_001033047	NP_001028219			nephronectin precursor						cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)														---	---	---	---
PAPSS1	9061	broad.mit.edu	37	4	108622349	108622349	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:108622349A>G	uc003hyk.2	-	2	237	c.153T>C	c.(151-153)CGT>CGC	p.R51R	PAPSS1_uc011cfh.1_RNA	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	51	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)														---	---	---	---
HADH	3033	broad.mit.edu	37	4	108940769	108940769	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:108940769C>T	uc003hyq.2	+	4	642	c.493C>T	c.(493-495)CGA>TGA	p.R165*	HADH_uc010ilx.2_Nonsense_Mutation_p.R165*|HADH_uc010ily.2_5'UTR|HADH_uc003hyr.2_Nonsense_Mutation_p.R169*	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	165					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)													---	---	---	---
AGXT2L1	64850	broad.mit.edu	37	4	109675819	109675819	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:109675819T>G	uc003hzc.2	-	5	639	c.458A>C	c.(457-459)AAG>ACG	p.K153T	AGXT2L1_uc010imc.2_Missense_Mutation_p.K147T|AGXT2L1_uc011cfm.1_Missense_Mutation_p.K113T|AGXT2L1_uc011cfn.1_Missense_Mutation_p.K80T|AGXT2L1_uc011cfo.1_Missense_Mutation_p.K95T	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	153					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)														---	---	---	---
GAR1	54433	broad.mit.edu	37	4	110739135	110739135	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110739135T>C	uc003hzt.2	+	3	565	c.258T>C	c.(256-258)TGT>TGC	p.C86C	GAR1_uc003hzu.2_Silent_p.C86C|GAR1_uc010imh.1_Silent_p.C86C|GAR1_uc010imi.2_Silent_p.C86C	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	86					rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0																		---	---	---	---
EGF	1950	broad.mit.edu	37	4	110909752	110909752	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110909752G>A	uc003hzy.3	+	18	3073	c.2621G>A	c.(2620-2622)TGT>TAT	p.C874Y	EGF_uc011cfu.1_Missense_Mutation_p.C832Y|EGF_uc011cfv.1_Missense_Mutation_p.C874Y|EGF_uc010imk.2_Intron	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	874	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)													---	---	---	---
ENPEP	2028	broad.mit.edu	37	4	111398135	111398135	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111398135A>G	uc003iab.3	+	1	907	c.565A>G	c.(565-567)ACC>GCC	p.T189A		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	189	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)													---	---	---	---
ENPEP	2028	broad.mit.edu	37	4	111409702	111409702	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111409702T>C	uc003iab.3	+	2	992	c.650T>C	c.(649-651)ATA>ACA	p.I217T		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	217	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)													---	---	---	---
ALPK1	80216	broad.mit.edu	37	4	113352170	113352170	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113352170C>T	uc003iap.3	+	11	1746	c.1467C>T	c.(1465-1467)TGC>TGT	p.C489C	ALPK1_uc003ian.3_Silent_p.C489C|ALPK1_uc011cfx.1_Silent_p.C411C|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Silent_p.C317C	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	489							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)														---	---	---	---
C4orf21	55345	broad.mit.edu	37	4	113540080	113540080	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113540080T>C	uc003iau.2	-	6	1329	c.1118A>G	c.(1117-1119)CAG>CGG	p.Q373R	C4orf21_uc003iaw.2_Missense_Mutation_p.Q373R	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)														---	---	---	---
LARP7	51574	broad.mit.edu	37	4	113568024	113568024	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113568024T>C	uc003iay.2	+	5	743	c.465T>C	c.(463-465)AGT>AGC	p.S155S	LARP7_uc003iaz.2_Silent_p.S162S|LARP7_uc003iba.2_Silent_p.S76S|LARP7_uc003ibb.2_Silent_p.S155S	NM_016648	NP_057732	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	155	RRM.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(3)	3		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114290964	114290964	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114290964A>G	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
PRSS12	8492	broad.mit.edu	37	4	119203203	119203203	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119203203A>G	uc003ica.1	-	13	2563	c.2516T>C	c.(2515-2517)GTG>GCG	p.V839A		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	839	Peptidase S1.			VVY -> AAL (in Ref. 3; AAD25919).		membrane	scavenger receptor activity			skin(1)	1																		---	---	---	---
PRSS12	8492	broad.mit.edu	37	4	119216958	119216958	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119216958T>A	uc003ica.1	-	10	1938	c.1891A>T	c.(1891-1893)ATC>TTC	p.I631F		NM_003619	NP_003610	P56730	NETR_HUMAN	neurotrypsin precursor	631	Peptidase S1.	Reactive bond homolog (Potential).				membrane	scavenger receptor activity			skin(1)	1																		---	---	---	---
PRDM5	11107	broad.mit.edu	37	4	121732558	121732558	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121732558A>G	uc003idn.2	-	8	1162	c.912T>C	c.(910-912)TGT>TGC	p.C304C	PRDM5_uc003ido.2_Silent_p.C273C|PRDM5_uc010ine.2_Silent_p.C273C	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	304	C2H2-type 5.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
PRDM5	11107	broad.mit.edu	37	4	121737729	121737729	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:121737729A>G	uc003idn.2	-	7	994	c.744T>C	c.(742-744)AGT>AGC	p.S248S	PRDM5_uc003ido.2_Silent_p.H217H|PRDM5_uc010ine.2_Silent_p.H217H|PRDM5_uc010inf.2_Silent_p.H217H	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	248	C2H2-type 3; atypical.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123109234	123109234	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123109234A>G	uc003ieh.2	+	7	857	c.812A>G	c.(811-813)CAA>CGA	p.Q271R	KIAA1109_uc003iei.1_Missense_Mutation_p.Q25R	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	271					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123128293	123128293	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123128293T>C	uc003ieh.2	+	14	1572	c.1527T>C	c.(1525-1527)AGT>AGC	p.S509S	KIAA1109_uc003iei.1_Silent_p.S263S|KIAA1109_uc010ins.1_5'UTR|KIAA1109_uc003iej.1_5'Flank	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	509					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123141513	123141513	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123141513G>A	uc003ieh.2	+	20	2546	c.2501G>A	c.(2500-2502)TGC>TAC	p.C834Y	KIAA1109_uc003iei.1_Missense_Mutation_p.C588Y|KIAA1109_uc010ins.1_Missense_Mutation_p.C178Y|KIAA1109_uc003iej.1_Missense_Mutation_p.C219Y	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	834					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123156180	123156180	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123156180T>C	uc003ieh.2	+	25	3619	c.3574_splice	c.e25+2	p.G1192_splice	KIAA1109_uc003iei.1_Splice_Site_p.G945_splice|KIAA1109_uc010ins.1_Splice_Site_p.G535_splice	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123161495	123161495	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123161495T>C	uc003ieh.2	+	27	4703	c.4658T>C	c.(4657-4659)GTT>GCT	p.V1553A	KIAA1109_uc003iei.1_Missense_Mutation_p.V1306A|KIAA1109_uc010ins.1_Missense_Mutation_p.V896A|KIAA1109_uc003iek.2_Missense_Mutation_p.V172A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1553					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123170828	123170828	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123170828A>G	uc003ieh.2	+	34	5746	c.5701A>G	c.(5701-5703)ACC>GCC	p.T1901A	KIAA1109_uc003iek.2_Missense_Mutation_p.T520A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1901					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123175388	123175388	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123175388A>T	uc003ieh.2	+	36	6006	c.5961A>T	c.(5959-5961)CTA>CTT	p.L1987L	KIAA1109_uc003iel.1_5'Flank|KIAA1109_uc003iek.2_Silent_p.L606L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1987					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123255605	123255605	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123255605A>G	uc003ieh.2	+	67	11798	c.11753A>G	c.(11752-11754)GAT>GGT	p.D3918G	KIAA1109_uc003iem.2_Intron	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3918					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
ADAD1	132612	broad.mit.edu	37	4	123342484	123342484	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123342484A>G	uc003ieo.2	+	12	1788	c.1556A>G	c.(1555-1557)AAC>AGC	p.N519S	ADAD1_uc003iep.2_Missense_Mutation_p.N508S|ADAD1_uc003ieq.2_Missense_Mutation_p.N501S	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	519	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0																		---	---	---	---
SPATA5	166378	broad.mit.edu	37	4	123949496	123949496	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123949496A>G	uc003iez.3	+	11	2098	c.2025A>G	c.(2023-2025)ACA>ACG	p.T675T	SPATA5_uc003iey.2_Silent_p.T674T	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	675	ATP 2 (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0																		---	---	---	---
ANKRD50	57182	broad.mit.edu	37	4	125591594	125591594	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:125591594A>G	uc003ifg.3	-	3	3104	c.2838T>C	c.(2836-2838)GGT>GGC	p.G946G	ANKRD50_uc011cgo.1_Silent_p.G767G|ANKRD50_uc010inw.2_Silent_p.G946G	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	946	ANK 15.									central_nervous_system(1)	1																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126240723	126240723	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126240723T>C	uc003ifj.3	+	1	3157	c.3157T>C	c.(3157-3159)TAT>CAT	p.Y1053H		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1053	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126328057	126328057	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126328057A>G	uc003ifj.3	+	3	5330	c.5330A>G	c.(5329-5331)TAC>TGC	p.Y1777C	FAT4_uc011cgp.1_Missense_Mutation_p.Y75C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1777	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126336235	126336235	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126336235T>C	uc003ifj.3	+	5	6117	c.6117T>C	c.(6115-6117)ATT>ATC	p.I2039I	FAT4_uc011cgp.1_Silent_p.I337I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2039	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126389698	126389698	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126389698T>C	uc003ifj.3	+	11	11931	c.11931T>C	c.(11929-11931)AGT>AGC	p.S3977S	FAT4_uc011cgp.1_Silent_p.S2240S|FAT4_uc003ifi.1_Silent_p.S1455S	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3977	Laminin G-like 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126398439	126398439	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126398439A>G	uc003ifj.3	+	13	12423	c.12423A>G	c.(12421-12423)GGA>GGG	p.G4141G	FAT4_uc011cgp.1_Silent_p.G2404G|FAT4_uc003ifi.1_Silent_p.G1619G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4141	Laminin G-like 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126400953	126400953	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126400953T>C	uc003ifj.3	+	14	12531	c.12531T>C	c.(12529-12531)TGT>TGC	p.C4177C	FAT4_uc011cgp.1_Intron|FAT4_uc003ifi.1_Silent_p.C1655C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4177	EGF-like 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126411790	126411790	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126411790A>G	uc003ifj.3	+	17	13813	c.13813A>G	c.(13813-13815)ATC>GTC	p.I4605V	FAT4_uc011cgp.1_Missense_Mutation_p.I2846V|FAT4_uc003ifi.1_Missense_Mutation_p.I2082V	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4605	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128554306	128554306	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128554306T>C	uc003ifk.1	+	1	187	c.117T>C	c.(115-117)GGT>GGC	p.G39G	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	39										ovary(1)	1																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128627893	128627893	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128627893A>G	uc003ifk.1	+	12	2110	c.2040A>G	c.(2038-2040)CTA>CTG	p.L680L	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	680										ovary(1)	1																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128632194	128632194	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128632194A>G	uc003ifk.1	+	14	2566	c.2496A>G	c.(2494-2496)ATA>ATG	p.I832M	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	832										ovary(1)	1																		---	---	---	---
PLK4	10733	broad.mit.edu	37	4	128814700	128814700	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128814700A>G	uc003ifo.2	+	12	2600	c.2355A>G	c.(2353-2355)ATA>ATG	p.I785M	PLK4_uc011cgs.1_Missense_Mutation_p.I753M|PLK4_uc011cgt.1_Missense_Mutation_p.I744M	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	785					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0																		---	---	---	---
PHF17	79960	broad.mit.edu	37	4	129783206	129783206	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:129783206T>C	uc003igk.2	+	9	1609	c.1329T>C	c.(1327-1329)CCT>CCC	p.P443P	PHF17_uc003igj.2_Silent_p.P443P|PHF17_uc003igl.2_Silent_p.P431P|PHF17_uc011cgy.1_Silent_p.P443P|PHF17_uc003igm.2_Silent_p.P443P	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	443					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0																		---	---	---	---
SCLT1	132320	broad.mit.edu	37	4	129878253	129878253	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:129878253T>C	uc003igp.2	-	13	1580	c.1074A>G	c.(1072-1074)GAA>GAG	p.E358E	SCLT1_uc003ign.2_Silent_p.E22E|SCLT1_uc003igo.2_5'UTR|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	358	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5																		---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134073171	134073171	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134073171A>G	uc003iha.2	+	1	2702	c.1876A>G	c.(1876-1878)ATG>GTG	p.M626V	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.M626V	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	626	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
PCDH18	54510	broad.mit.edu	37	4	138451686	138451686	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:138451686G>T	uc003ihe.3	-	1	1944	c.1557C>A	c.(1555-1557)ACC>ACA	p.T519T	PCDH18_uc003ihf.3_Silent_p.T512T|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Silent_p.T299T|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	519	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)																	---	---	---	---
MAML3	55534	broad.mit.edu	37	4	140810714	140810714	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:140810714T>C	uc003ihz.1	-	3	2616	c.1864A>G	c.(1864-1866)AAC>GAC	p.N622D	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	622	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)																	---	---	---	---
CLGN	1047	broad.mit.edu	37	4	141311858	141311858	+	Missense_Mutation	SNP	T	C	C	rs113979220		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:141311858T>C	uc011chi.1	-	15	1894	c.1676A>G	c.(1675-1677)AAG>AGG	p.K559R	CLGN_uc003iii.2_Missense_Mutation_p.K559R	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	559	Cytoplasmic (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)																	---	---	---	---
OTUD4	54726	broad.mit.edu	37	4	146059468	146059468	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146059468C>T	uc003ika.3	-	21	2402	c.2264G>A	c.(2263-2265)GGG>GAG	p.G755E	OTUD4_uc003ijz.3_Missense_Mutation_p.G754E	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	819							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)																	---	---	---	---
MMAA	166785	broad.mit.edu	37	4	146560420	146560420	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146560420G>A	uc003ikh.3	+	2	214	c.129G>A	c.(127-129)CCG>CCA	p.P43P	MMAA_uc003ikg.2_Silent_p.P43P|MMAA_uc003iki.1_RNA|MMAA_uc010iow.2_RNA	NM_172250	NP_758454	Q8IVH4	MMAA_HUMAN	methylmalonic aciduria type A precursor	43						mitochondrion	GTP binding|nucleoside-triphosphatase activity			ovary(1)	1	all_hematologic(180;0.151)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
POU4F2	5458	broad.mit.edu	37	4	147561397	147561397	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:147561397G>T	uc003ikv.2	+	2	915	c.667G>T	c.(667-669)GCC>TCC	p.A223S		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	223					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)																	---	---	---	---
ARHGAP10	79658	broad.mit.edu	37	4	148993227	148993227	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148993227C>T	uc003ilf.2	+	23	2356	c.2356C>T	c.(2356-2358)CTG>TTG	p.L786L	ARHGAP10_uc003ilg.2_Silent_p.L384L|ARHGAP10_uc003ilh.2_Silent_p.L367L|ARHGAP10_uc003ili.2_Silent_p.L219L	NM_024605	NP_078881	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	786	SH3.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)														---	---	---	---
NR3C2	4306	broad.mit.edu	37	4	149002532	149002532	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:149002532G>A	uc003ilj.3	-	9	3252	c.2918C>T	c.(2917-2919)TCG>TTG	p.S973L	NR3C2_uc003ilk.3_Missense_Mutation_p.S856L|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	973	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)													---	---	---	---
NR3C2	4306	broad.mit.edu	37	4	149357029	149357029	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:149357029A>G	uc003ilj.3	-	2	1318	c.984T>C	c.(982-984)AGT>AGC	p.S328S	NR3C2_uc003ilk.3_Silent_p.S328S|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	328	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)													---	---	---	---
LRBA	987	broad.mit.edu	37	4	151236759	151236759	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151236759T>C	uc010ipj.2	-	52	8154	c.7680A>G	c.(7678-7680)GTA>GTG	p.V2560V	LRBA_uc010ipi.2_Silent_p.V82V|LRBA_uc003ils.3_Silent_p.V455V|LRBA_uc003ilt.3_Silent_p.V1208V|LRBA_uc003ilu.3_Silent_p.V2549V	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2560						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
LRBA	987	broad.mit.edu	37	4	151356858	151356858	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151356858T>C	uc010ipj.2	-	47	7431	c.6957A>G	c.(6955-6957)GAA>GAG	p.E2319E	LRBA_uc010ipi.2_Intron|LRBA_uc003ils.3_Silent_p.E209E|LRBA_uc003ilt.3_Silent_p.E967E|LRBA_uc003ilu.3_Silent_p.E2308E	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2319	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
MAB21L2	10586	broad.mit.edu	37	4	151504269	151504269	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151504269A>G	uc003ilw.2	+	1	1193	c.88A>G	c.(88-90)ACC>GCC	p.T30A	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	30					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)														---	---	---	---
LRBA	987	broad.mit.edu	37	4	151604819	151604819	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151604819A>G	uc010ipj.2	-	37	6279	c.5805T>C	c.(5803-5805)TGT>TGC	p.C1935C	LRBA_uc003ilt.3_Silent_p.C594C|LRBA_uc003ilu.3_Silent_p.C1935C	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1935						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
PRSS48	345062	broad.mit.edu	37	4	152212379	152212379	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:152212379A>C	uc011cif.1	+	5	761	c.761A>C	c.(760-762)AAT>ACT	p.N254T	PRSS48_uc011cig.1_Missense_Mutation_p.N111T	NM_183375	NP_899231	Q7RTY5	PRS48_HUMAN	epidermis-specific serine protease-like protein	254	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.G254R(1)		large_intestine(1)	1																		---	---	---	---
FBXW7	55294	broad.mit.edu	37	4	153247360	153247360	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153247360G>A	uc003ims.2	-	10	1591	c.1442C>T	c.(1441-1443)GCC>GTC	p.A481V	FBXW7_uc011cii.1_Missense_Mutation_p.A481V|FBXW7_uc003imt.2_Missense_Mutation_p.A481V|FBXW7_uc011cih.1_Missense_Mutation_p.A305V|FBXW7_uc003imq.2_Missense_Mutation_p.A401V|FBXW7_uc003imr.2_Missense_Mutation_p.A363V	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	481	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)						Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---	---
FBXW7	55294	broad.mit.edu	37	4	153273753	153273753	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153273753A>G	uc003ims.2	-						FBXW7_uc011cii.1_Intron|FBXW7_uc003imt.2_Intron|FBXW7_uc003imq.2_Missense_Mutation_p.Y44H|FBXW7_uc003imr.2_Intron	NM_033632	NP_361014			F-box and WD repeat domain containing 7 isoform						interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)						Mis|N|D|F		colorectal|endometrial|T-ALL								---	---	---	---
FHDC1	85462	broad.mit.edu	37	4	153874647	153874647	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:153874647C>T	uc003inf.2	+							NM_033393	NP_203751			FH2 domain containing 1						actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)																	---	---	---	---
RNF175	285533	broad.mit.edu	37	4	154636790	154636790	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154636790T>C	uc003int.2	-	7	1028	c.655A>G	c.(655-657)ACA>GCA	p.T219A	RNF175_uc003inu.1_Missense_Mutation_p.T91A	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	219						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
PLRG1	5356	broad.mit.edu	37	4	155468901	155468901	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155468901G>A	uc003iny.2	-	3	284	c.221C>T	c.(220-222)ACG>ATG	p.T74M	PLRG1_uc003inz.2_Missense_Mutation_p.T74M|PLRG1_uc011cil.1_Translation_Start_Site	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	74						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)																---	---	---	---
NPY2R	4887	broad.mit.edu	37	4	156135287	156135287	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156135287A>T	uc003ioq.2	+	2	691	c.196A>T	c.(196-198)ATT>TTT	p.I66F	NPY2R_uc003ior.2_Missense_Mutation_p.I66F	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	66	Helical; Name=1; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)																---	---	---	---
GUCY1A3	2982	broad.mit.edu	37	4	156618283	156618283	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156618283G>A	uc003iov.2	+						GUCY1A3_uc003iou.2_Intron|GUCY1A3_uc010iqc.2_Intron|GUCY1A3_uc003iow.2_Intron|GUCY1A3_uc010iqd.2_Intron|GUCY1A3_uc003iox.2_Intron|GUCY1A3_uc003ioz.2_Intron|GUCY1A3_uc003ioy.2_Intron|GUCY1A3_uc010iqe.2_Intron|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Intron	NM_000856	NP_000847			guanylate cyclase 1, soluble, alpha 3 isoform A						blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)														---	---	---	---
GUCY1B3	2983	broad.mit.edu	37	4	156721148	156721148	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156721148C>T	uc003ipc.2	+	9	1264	c.1097C>T	c.(1096-1098)ACC>ATC	p.T366I	GUCY1B3_uc011cio.1_Missense_Mutation_p.T388I|GUCY1B3_uc011cip.1_Missense_Mutation_p.T346I|GUCY1B3_uc003ipd.2_Missense_Mutation_p.T294I|GUCY1B3_uc010iqf.2_Missense_Mutation_p.T366I|GUCY1B3_uc010iqg.2_Missense_Mutation_p.T294I|GUCY1B3_uc011ciq.1_Missense_Mutation_p.T294I	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	366					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)														---	---	---	---
PDGFC	56034	broad.mit.edu	37	4	157693895	157693895	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:157693895A>G	uc003iph.1	-	4	1137	c.646T>C	c.(646-648)TAT>CAT	p.Y216H	PDGFC_uc003ipi.1_Missense_Mutation_p.Y53H|PDGFC_uc011cis.1_Missense_Mutation_p.Y53H|PDGFC_uc011cir.1_Missense_Mutation_p.Y60H	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	216					central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)														---	---	---	---
FAM198B	51313	broad.mit.edu	37	4	159091420	159091420	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159091420T>A	uc003ipp.3	-						uc003ipu.1_5'Flank|FAM198B_uc003ipq.3_Missense_Mutation_p.K330N|FAM198B_uc003ipr.3_Intron|FAM198B_uc003ips.2_3'UTR|uc003ipt.1_5'Flank	NM_016613	NP_057697			hypothetical protein LOC51313 isoform 2							Golgi membrane|integral to membrane					0																		---	---	---	---
RXFP1	59350	broad.mit.edu	37	4	159559213	159559213	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159559213T>C	uc003ipz.2	+	13	1107	c.1025T>C	c.(1024-1026)CTT>CCT	p.L342P	RXFP1_uc010iqj.1_Missense_Mutation_p.L171P|RXFP1_uc011cja.1_Missense_Mutation_p.L237P|RXFP1_uc010iqo.2_Intron|RXFP1_uc011cjb.1_Intron|RXFP1_uc010iqk.2_Missense_Mutation_p.L210P|RXFP1_uc011cjc.1_Missense_Mutation_p.L261P|RXFP1_uc011cjd.1_Missense_Mutation_p.L261P|RXFP1_uc010iql.2_Missense_Mutation_p.L186P|RXFP1_uc011cje.1_Missense_Mutation_p.L369P|RXFP1_uc010iqm.2_Missense_Mutation_p.L309P|RXFP1_uc011cjf.1_Missense_Mutation_p.L212P|RXFP1_uc010iqn.2_Missense_Mutation_p.L288P	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	342	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)														---	---	---	---
RXFP1	59350	broad.mit.edu	37	4	159569818	159569818	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159569818A>T	uc003ipz.2	+	17	2006	c.1924A>T	c.(1924-1926)ATA>TTA	p.I642L	RXFP1_uc011cja.1_Missense_Mutation_p.I537L|RXFP1_uc010iqo.2_Missense_Mutation_p.I594L|RXFP1_uc011cjb.1_Missense_Mutation_p.I540L|RXFP1_uc010iqk.2_Missense_Mutation_p.I510L|RXFP1_uc011cjc.1_Missense_Mutation_p.I561L|RXFP1_uc011cjd.1_Missense_Mutation_p.I561L|RXFP1_uc010iql.2_Missense_Mutation_p.I486L|RXFP1_uc011cje.1_Missense_Mutation_p.I669L|RXFP1_uc010iqm.2_Missense_Mutation_p.I609L|RXFP1_uc011cjf.1_Missense_Mutation_p.I511L|RXFP1_uc010iqn.2_Missense_Mutation_p.I587L	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	642	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)														---	---	---	---
FNIP2	57600	broad.mit.edu	37	4	159780291	159780291	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159780291A>G	uc003iqe.3	+	9	1123	c.940A>G	c.(940-942)AGC>GGC	p.S314G		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	314					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)														---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162376252	162376252	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162376252G>T	uc003iqh.2	-	15	2181	c.1745C>A	c.(1744-1746)CCT>CAT	p.P582H	FSTL5_uc003iqi.2_Missense_Mutation_p.P581H|FSTL5_uc010iqv.2_Missense_Mutation_p.P572H	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	582						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162459394	162459394	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162459394A>G	uc003iqh.2	-	10	1672	c.1236T>C	c.(1234-1236)ACT>ACC	p.T412T	FSTL5_uc003iqi.2_Silent_p.T411T|FSTL5_uc010iqv.2_Silent_p.T411T	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	412	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162463689	162463689	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162463689A>G	uc003iqh.2	-	9	1608	c.1172T>C	c.(1171-1173)CTT>CCT	p.L391P	FSTL5_uc003iqi.2_Missense_Mutation_p.L390P|FSTL5_uc010iqv.2_Missense_Mutation_p.L390P	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	391	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162697185	162697185	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162697185T>C	uc003iqh.2	-	5	887	c.451A>G	c.(451-453)ATG>GTG	p.M151V	FSTL5_uc003iqi.2_Missense_Mutation_p.M150V|FSTL5_uc010iqv.2_Missense_Mutation_p.M150V	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	151						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
TKTL2	84076	broad.mit.edu	37	4	164393014	164393014	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:164393014T>G	uc003iqp.3	-	1	2034	c.1873A>C	c.(1873-1875)ATG>CTG	p.M625L		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	625						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)																---	---	---	---
TKTL2	84076	broad.mit.edu	37	4	164394169	164394169	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:164394169T>C	uc003iqp.3	-	1	879	c.718A>G	c.(718-720)ACT>GCT	p.T240A		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	240						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)																---	---	---	---
Unknown	0	broad.mit.edu	37	4	165981469	165981469	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:165981469A>G	uc011cjl.1	+	1	1170	c.1170A>G	c.(1168-1170)CAA>CAG	p.Q390Q		NM_001105575	NP_001099045			tripartite motif-containing 75																														---	---	---	---
KLHL2	11275	broad.mit.edu	37	4	166160048	166160048	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166160048A>G	uc003irb.2	+	4	637	c.378A>G	c.(376-378)GTA>GTG	p.V126V	KLHL2_uc011cjm.1_Silent_p.V130V|KLHL2_uc003irc.2_Silent_p.V38V	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	126					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)														---	---	---	---
SC4MOL	6307	broad.mit.edu	37	4	166254547	166254547	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166254547A>G	uc003ire.2	+	2	155	c.25A>G	c.(25-27)ATC>GTC	p.I9V	SC4MOL_uc010irb.2_Missense_Mutation_p.I9V|SC4MOL_uc003irf.2_Intron	NM_006745	NP_006736	Q15800	ERG25_HUMAN	sterol-C4-methyl oxidase-like isoform 1	9					cholesterol biosynthetic process|fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	C-4 methylsterol oxidase activity|iron ion binding				0	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0875)	NADH(DB00157)													---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169146804	169146804	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169146804C>A	uc003irp.2	-	34	4849	c.4557G>T	c.(4555-4557)GAG>GAT	p.E1519D	DDX60_uc003iro.2_Translation_Start_Site	NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1519							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169300872	169300872	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169300872G>A	uc003irq.3	-							NM_001012967	NP_001012985			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169325220	169325220	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169325220A>G	uc003irq.3	-	25	3472	c.3251T>C	c.(3250-3252)TTG>TCG	p.L1084S	DDX60L_uc003irr.1_Missense_Mutation_p.L1084S|DDX60L_uc003irs.1_Missense_Mutation_p.L779S	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1084							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
PALLD	23022	broad.mit.edu	37	4	169845505	169845505	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169845505T>C	uc011cjx.1	+	19	3369	c.3158T>C	c.(3157-3159)GTG>GCG	p.V1053A	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Missense_Mutation_p.V1036A|PALLD_uc003irv.2_Missense_Mutation_p.V654A|PALLD_uc003irw.2_Missense_Mutation_p.V538A|PALLD_uc003irx.2_Missense_Mutation_p.V262A	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	1260	Ig-like C2-type 5.|Interaction with EZR.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)										Pancreatic_Cancer_Familial_Clustering_of				---	---	---	---
NEK1	4750	broad.mit.edu	37	4	170498105	170498105	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170498105T>C	uc003isb.1	-	11	1486	c.994A>G	c.(994-996)AAG>GAG	p.K332E	NEK1_uc003isc.1_Missense_Mutation_p.K332E|NEK1_uc003isd.1_Missense_Mutation_p.K332E|NEK1_uc003ise.1_Missense_Mutation_p.K332E|NEK1_uc003isf.1_Missense_Mutation_p.K332E|NEK1_uc003isg.1_Missense_Mutation_p.K253E	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	332					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)														---	---	---	---
CLCN3	1182	broad.mit.edu	37	4	170618838	170618838	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170618838G>A	uc003isi.2	+	9	2025	c.1516G>A	c.(1516-1518)GCA>ACA	p.A506T	CLCN3_uc003ish.2_Missense_Mutation_p.A506T|CLCN3_uc011cjz.1_Missense_Mutation_p.A489T|CLCN3_uc011cka.1_Missense_Mutation_p.A479T|CLCN3_uc003isj.1_Missense_Mutation_p.A479T	NM_001829	NP_001820	P51790	CLCN3_HUMAN	chloride channel 3 isoform b	506	Helical; (By similarity).				endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(2)|ovary(1)	3		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)														---	---	---	---
MFAP3L	9848	broad.mit.edu	37	4	170913013	170913013	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170913013T>C	uc003isp.3	-	3	924	c.746A>G	c.(745-747)AAC>AGC	p.N249S	MFAP3L_uc003isn.3_Missense_Mutation_p.N146S	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	249	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)														---	---	---	---
AADAT	51166	broad.mit.edu	37	4	170983111	170983111	+	Missense_Mutation	SNP	C	T	T	rs139598358		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170983111C>T	uc003isr.2	-	12	1510	c.1168G>A	c.(1168-1170)GAT>AAT	p.D390N	AADAT_uc003iss.2_Missense_Mutation_p.D390N|AADAT_uc003ist.2_Missense_Mutation_p.D394N	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II	390					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173232782	173232782	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173232782A>G	uc003isv.2	+	4	1001	c.265A>G	c.(265-267)AAA>GAA	p.K89E		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	89	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173873306	173873306	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173873306A>C	uc003isv.2	+	10	2004	c.1268A>C	c.(1267-1269)AAG>ACG	p.K423T		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	423	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
GALNT7	51809	broad.mit.edu	37	4	174219377	174219377	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:174219377T>C	uc003isz.3	+	6	1160	c.1077T>C	c.(1075-1077)AGT>AGC	p.S359S	GALNT7_uc011ckb.1_Intron	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	359	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)														---	---	---	---
ADAM29	11086	broad.mit.edu	37	4	175897485	175897485	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:175897485G>A	uc003iuc.2	+	5	1479	c.809G>A	c.(808-810)TGC>TAC	p.C270Y	ADAM29_uc003iud.2_Missense_Mutation_p.C270Y|ADAM29_uc010irr.2_Missense_Mutation_p.C270Y|ADAM29_uc011cki.1_Missense_Mutation_p.C270Y	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	270	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183603166	183603166	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183603166C>T	uc003ivd.1	+	10	2071	c.2034C>T	c.(2032-2034)AAC>AAT	p.N678N	ODZ3_uc003ive.1_Silent_p.N84N	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	678	Extracellular (Potential).|EGF-like 6.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183664498	183664498	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183664498T>A	uc003ivd.1	+	18	3592	c.3555T>A	c.(3553-3555)AGT>AGA	p.S1185R	ODZ3_uc003ive.1_Missense_Mutation_p.S591R	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1185	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183675540	183675540	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183675540A>G	uc003ivd.1	+	21	4057	c.4020A>G	c.(4018-4020)GTA>GTG	p.V1340V	ODZ3_uc003ive.1_Silent_p.V753V	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1340	Extracellular (Potential).|NHL 3.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183710405	183710405	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183710405A>G	uc003ivd.1	+	24	5501	c.5464A>G	c.(5464-5466)ACC>GCC	p.T1822A		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1822	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183721189	183721189	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183721189C>T	uc003ivd.1	+	27	7822	c.7785C>T	c.(7783-7785)GAC>GAT	p.D2595D		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2595	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
CCDC111	201973	broad.mit.edu	37	4	185593425	185593425	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185593425T>C	uc003iwk.2	+	7	1088	c.655T>C	c.(655-657)TTT>CTT	p.F219L	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Missense_Mutation_p.F219L|CCDC111_uc003iwl.2_Missense_Mutation_p.F219L|CCDC111_uc003iwm.2_Missense_Mutation_p.F90L|CCDC111_uc003iwn.2_Missense_Mutation_p.F44L	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	219					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)														---	---	---	---
HELT	391723	broad.mit.edu	37	4	185940960	185940960	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185940960A>G	uc011ckq.1	+	3	447	c.447A>G	c.(445-447)GCA>GCG	p.A149A	HELT_uc011cko.1_Silent_p.A64A|HELT_uc003ixa.3_Silent_p.A64A|HELT_uc011ckp.1_Silent_p.A8A	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	149	Helix-loop-helix motif.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)														---	---	---	---
SNX25	83891	broad.mit.edu	37	4	186274723	186274723	+	Missense_Mutation	SNP	A	G	G	rs149097763		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186274723A>G	uc003ixh.2	+	15	2248	c.2059A>G	c.(2059-2061)ATG>GTG	p.M687V	SNX25_uc010ish.2_Missense_Mutation_p.M403V|SNX25_uc003ixi.2_Missense_Mutation_p.M191V	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	687					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)														---	---	---	---
PDLIM3	27295	broad.mit.edu	37	4	186435463	186435463	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186435463T>C	uc003ixw.3	-	4	483	c.359A>G	c.(358-360)AAT>AGT	p.N120S	PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron|PDLIM3_uc003ixy.2_Missense_Mutation_p.I183V|PDLIM3_uc003ixz.2_Missense_Mutation_p.I183V	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	120						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)														---	---	---	---
SORBS2	8470	broad.mit.edu	37	4	186533064	186533064	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186533064C>A	uc003iyl.2	-	18	3812	c.2954G>T	c.(2953-2955)AGA>ATA	p.R985I	SORBS2_uc003iyh.2_Missense_Mutation_p.R709I|SORBS2_uc011ckw.1_Missense_Mutation_p.R546I|SORBS2_uc003iyi.2_Missense_Mutation_p.R616I|SORBS2_uc011ckx.1_Missense_Mutation_p.R551I|SORBS2_uc003iyk.2_Missense_Mutation_p.R529I|SORBS2_uc003iym.2_Missense_Mutation_p.R1085I|SORBS2_uc003iyn.1_Missense_Mutation_p.R576I|SORBS2_uc011cku.1_Missense_Mutation_p.R377I|SORBS2_uc011ckv.1_Missense_Mutation_p.R889I|SORBS2_uc003iyd.2_Missense_Mutation_p.R684I|SORBS2_uc003iye.2_Missense_Mutation_p.R558I|SORBS2_uc003iya.2_Missense_Mutation_p.R505I|SORBS2_uc003iyb.2_Missense_Mutation_p.R458I|SORBS2_uc003iyc.2_Missense_Mutation_p.R438I|SORBS2_uc003iyg.2_Missense_Mutation_p.R1099I|SORBS2_uc003iyf.2_Missense_Mutation_p.R521I|SORBS2_uc003iyo.1_Missense_Mutation_p.R434I	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	985	SH3 2.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)														---	---	---	---
SORBS2	8470	broad.mit.edu	37	4	186544622	186544622	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:186544622T>C	uc003iyl.2	-	13	2807	c.1949A>G	c.(1948-1950)CAC>CGC	p.H650R	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.H750R|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.H554R|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.H764R|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	650	His-rich.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)														---	---	---	---
TLR3	7098	broad.mit.edu	37	4	187000110	187000110	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187000110A>G	uc003iyq.2	+	3	659	c.558A>G	c.(556-558)CTA>CTG	p.L186L	TLR3_uc011ckz.1_5'Flank	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	186	Lumenal (Potential).|LRR 6.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)														---	---	---	---
TLR3	7098	broad.mit.edu	37	4	187005313	187005313	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187005313C>T	uc003iyq.2	+	4	2574	c.2473C>T	c.(2473-2475)CCA>TCA	p.P825S	TLR3_uc011ckz.1_Missense_Mutation_p.P548S|TLR3_uc003iyr.2_Missense_Mutation_p.P548S	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	825	Cytoplasmic (Potential).|TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)														---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187549306	187549306	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187549306A>G	uc003izf.2	-	9	4998	c.4810_splice	c.e9+1	p.G1604_splice		NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
SDHA	6389	broad.mit.edu	37	5	240561	240561	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:240561A>G	uc003jao.3	+	11	1636	c.1521A>G	c.(1519-1521)AGA>AGG	p.R507R	SDHA_uc011clv.1_Silent_p.R507R|SDHA_uc011clw.1_Silent_p.R459R|SDHA_uc003jap.3_Silent_p.R507R|SDHA_uc003jaq.3_Silent_p.R282R|SDHA_uc003jar.3_Silent_p.R101R	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	507					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)									Familial_Paragangliomas				---	---	---	---
CEP72	55722	broad.mit.edu	37	5	635582	635582	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:635582T>C	uc003jbf.2	+	6	859	c.787T>C	c.(787-789)TGC>CGC	p.C263R	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	263					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)															---	---	---	---
TPPP	11076	broad.mit.edu	37	5	678016	678016	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:678016C>T	uc003jbg.3	-	1	878	c.160G>A	c.(160-162)GCC>ACC	p.A54T	TPPP_uc003jbh.3_Missense_Mutation_p.A54T	NM_007030	NP_008961	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	54	Mediates interaction with LIMK1.				microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding				0		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)														---	---	---	---
BRD9	65980	broad.mit.edu	37	5	889777	889777	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:889777A>G	uc003jbq.2	-						BRD9_uc003jbl.2_Missense_Mutation_p.F13S|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Intron|BRD9_uc003jbo.2_Missense_Mutation_p.F13S|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413			bromodomain containing 9 isoform 1								nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)															---	---	---	---
TRIP13	9319	broad.mit.edu	37	5	908157	908157	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:908157A>G	uc003jbr.2	+	8	837	c.727A>G	c.(727-729)AAA>GAA	p.K243E	TRIP13_uc010ite.1_Missense_Mutation_p.K243E	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	243					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)															---	---	---	---
TRIP13	9319	broad.mit.edu	37	5	916037	916037	+	Silent	SNP	C	T	T	rs147247158		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:916037C>T	uc003jbr.2	+	12	1262	c.1152C>T	c.(1150-1152)AGC>AGT	p.S384S		NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	384					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)															---	---	---	---
NKD2	85409	broad.mit.edu	37	5	1037966	1037966	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1037966G>A	uc003jbt.1	+	10	839	c.834G>A	c.(832-834)TCG>TCA	p.S278S	NKD2_uc010itf.1_3'UTR	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	278					exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)															---	---	---	---
SLC6A19	340024	broad.mit.edu	37	5	1221330	1221330	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1221330C>T	uc003jbw.3	+	11	1659	c.1603C>T	c.(1603-1605)CGC>TGC	p.R535C		NM_001003841	NP_001003841	Q695T7	S6A19_HUMAN	solute carrier family 6, member 19	535	Helical; Name=11; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)															---	---	---	---
CLPTM1L	81037	broad.mit.edu	37	5	1331946	1331946	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1331946T>C	uc003jch.2	-	8	990	c.944A>G	c.(943-945)AAG>AGG	p.K315R	CLPTM1L_uc003jcg.2_Missense_Mutation_p.K182R	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	315	Cytoplasmic (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)														---	---	---	---
IRX1	79192	broad.mit.edu	37	5	3600153	3600153	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:3600153A>G	uc003jde.2	+	2	1143	c.1091A>G	c.(1090-1092)TAC>TGC	p.Y364C		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	364						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ADAMTS16	170690	broad.mit.edu	37	5	5235263	5235263	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5235263C>T	uc003jdl.2	+	13	2125	c.1987C>T	c.(1987-1989)CGG>TGG	p.R663W	ADAMTS16_uc003jdk.1_Missense_Mutation_p.R663W|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	663	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8																		---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5473675	5473675	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5473675C>T	uc003jdm.3	+	16	6449	c.6227C>T	c.(6226-6228)GCC>GTC	p.A2076V		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2076										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5476116	5476116	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5476116G>A	uc003jdm.3	+	17	6666	c.6444G>A	c.(6442-6444)TGG>TGA	p.W2148*		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2148										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
SEMA5A	9037	broad.mit.edu	37	5	9136697	9136697	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:9136697C>A	uc003jek.2	-	13	2230	c.1518G>T	c.(1516-1518)TGG>TGT	p.W506C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	506	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CTNND2	1501	broad.mit.edu	37	5	11023012	11023012	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:11023012C>T	uc003jfa.1	-	17	3013	c.2868G>A	c.(2866-2868)TCG>TCA	p.S956S	CTNND2_uc010itt.2_Silent_p.S865S|CTNND2_uc011cmy.1_Silent_p.S619S|CTNND2_uc011cmz.1_Silent_p.S523S|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.S548S	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	956					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8																		---	---	---	---
CTNND2	1501	broad.mit.edu	37	5	11199700	11199700	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:11199700G>A	uc003jfa.1	-	11	1980	c.1835C>T	c.(1834-1836)GCC>GTC	p.A612V	CTNND2_uc010itt.2_Missense_Mutation_p.A521V|CTNND2_uc011cmy.1_Missense_Mutation_p.A275V|CTNND2_uc011cmz.1_Missense_Mutation_p.A179V|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.A179V	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	612	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13721260	13721260	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13721260G>A	uc003jfd.2	-	71	12170	c.12128C>T	c.(12127-12129)ACG>ATG	p.T4043M	DNAH5_uc003jfc.2_Missense_Mutation_p.T211M	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4043	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13830698	13830698	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13830698A>G	uc003jfd.2	-							NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14291346	14291346	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14291346G>A	uc003jff.2	+						TRIO_uc003jfg.2_Intron|TRIO_uc011cna.1_Intron|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049			triple functional domain (PTPRF interacting)						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
FAM105B	90268	broad.mit.edu	37	5	14692970	14692970	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14692970T>C	uc003jfk.2	+	7	1024	c.872T>C	c.(871-873)ATG>ACG	p.M291T		NM_138348	NP_612357	Q96BN8	F105B_HUMAN	hypothetical protein LOC90268	291										ovary(2)	2	Lung NSC(4;0.00696)																	---	---	---	---
FBXL7	23194	broad.mit.edu	37	5	15928130	15928130	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:15928130A>G	uc003jfn.1	+	3	740	c.259A>G	c.(259-261)ATG>GTG	p.M87V		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	87					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3																		---	---	---	---
FBXL7	23194	broad.mit.edu	37	5	15928377	15928377	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:15928377C>T	uc003jfn.1	+	3	987	c.506C>T	c.(505-507)GCC>GTC	p.A169V		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	169					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3																		---	---	---	---
MYO10	4651	broad.mit.edu	37	5	16670845	16670845	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:16670845C>T	uc003jft.3	-	39	6141	c.5673G>A	c.(5671-5673)CGG>CGA	p.R1891R	MYO10_uc011cnb.1_Silent_p.R520R|MYO10_uc011cnc.1_Silent_p.R770R|MYO10_uc011cnd.1_Silent_p.R1248R|MYO10_uc011cne.1_Silent_p.R1248R|MYO10_uc010itx.2_Silent_p.R1513R	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1891	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
CDH18	1016	broad.mit.edu	37	5	19520773	19520773	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:19520773G>T	uc003jgc.2	-	9	1882	c.1505C>A	c.(1504-1506)CCT>CAT	p.P502H	CDH18_uc003jgd.2_Missense_Mutation_p.P502H|CDH18_uc011cnm.1_Missense_Mutation_p.P502H	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	502	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)																	---	---	---	---
CDH10	1008	broad.mit.edu	37	5	24593567	24593567	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:24593567T>A	uc003jgr.1	-	2	365	c.33A>T	c.(31-33)CTA>CTT	p.L11L	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	11					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)											HNSCC(23;0.051)			---	---	---	---
CDH9	1007	broad.mit.edu	37	5	26885845	26885845	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:26885845C>T	uc003jgs.1	-	11	1929	c.1760G>A	c.(1759-1761)CGT>CAT	p.R587H	CDH9_uc011cnv.1_Missense_Mutation_p.R180H	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	587	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9																		---	---	---	---
CDH6	1004	broad.mit.edu	37	5	31305309	31305309	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31305309A>T	uc003jhe.1	+	7	1354	c.1028A>T	c.(1027-1029)TAT>TTT	p.Y343F	CDH6_uc003jhd.1_Missense_Mutation_p.Y343F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	343	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32052721	32052721	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32052721A>G	uc003jhl.2	+	9	2058	c.1670A>G	c.(1669-1671)TAC>TGC	p.Y557C	PDZD2_uc003jhm.2_Missense_Mutation_p.Y557C|PDZD2_uc011cnx.1_Missense_Mutation_p.Y383C	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	557					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
PDZD2	23037	broad.mit.edu	37	5	32061149	32061149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32061149G>A	uc003jhl.2	+	14	2748	c.2360G>A	c.(2359-2361)CGC>CAC	p.R787H	PDZD2_uc003jhm.2_Missense_Mutation_p.R787H|PDZD2_uc011cnx.1_Missense_Mutation_p.R613H	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	787	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9																		---	---	---	---
ZFR	51663	broad.mit.edu	37	5	32390499	32390499	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32390499T>C	uc003jhr.1	-	12	2104	c.2024A>G	c.(2023-2025)CAA>CGA	p.Q675R	ZFR_uc011cny.1_5'Flank	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	675					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)														---	---	---	---
NPR3	4883	broad.mit.edu	37	5	32712294	32712294	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32712294T>C	uc003jhv.2	+	1	630	c.412T>C	c.(412-414)TAT>CAT	p.Y138H	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.Y138H	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	138	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)													---	---	---	---
NPR3	4883	broad.mit.edu	37	5	32712393	32712393	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32712393T>C	uc003jhv.2	+	1	729	c.511T>C	c.(511-513)TAC>CAC	p.Y171H	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.Y171H	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	171	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)													---	---	---	---
TARS	6897	broad.mit.edu	37	5	33457407	33457407	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33457407C>T	uc003jhy.2	+	9	1178	c.883C>T	c.(883-885)CAG>TAG	p.Q295*	TARS_uc011cob.1_Nonsense_Mutation_p.Q283*|TARS_uc010iup.1_Nonsense_Mutation_p.Q236*|TARS_uc011coc.1_Nonsense_Mutation_p.Q316*|TARS_uc003jhz.2_Nonsense_Mutation_p.Q191*|TARS_uc011cod.1_Nonsense_Mutation_p.Q174*	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	295					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)													---	---	---	---
ADAMTS12	81792	broad.mit.edu	37	5	33751615	33751615	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33751615A>G	uc003jia.1	-	3	691	c.528T>C	c.(526-528)ATT>ATC	p.I176I	ADAMTS12_uc010iuq.1_Silent_p.I176I|ADAMTS12_uc003jib.1_Silent_p.I176I	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	176					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9															HNSCC(64;0.19)			---	---	---	---
RXFP3	51289	broad.mit.edu	37	5	33937720	33937720	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:33937720G>A	uc003jic.1	+	1	1232	c.875G>A	c.(874-876)CGC>CAC	p.R292H		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	292	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
RAI14	26064	broad.mit.edu	37	5	34824309	34824309	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34824309T>C	uc003jir.2	+	15	2558	c.2362T>C	c.(2362-2364)TCC>CCC	p.S788P	RAI14_uc010iur.2_Missense_Mutation_p.S759P|RAI14_uc011coj.1_Missense_Mutation_p.S788P|RAI14_uc003jis.2_Missense_Mutation_p.S791P|RAI14_uc003jit.2_Missense_Mutation_p.S788P|RAI14_uc011cok.1_Missense_Mutation_p.S780P	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	788	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)																	---	---	---	---
AGXT2	64902	broad.mit.edu	37	5	35026572	35026572	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35026572A>G	uc003jjf.2	-	8	892	c.813T>C	c.(811-813)GAT>GAC	p.D271D	AGXT2_uc003jje.1_5'Flank|AGXT2_uc011com.1_Silent_p.D271D	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	271					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)													---	---	---	---
SPEF2	79925	broad.mit.edu	37	5	35700587	35700587	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35700587T>A	uc003jjo.2	+						SPEF2_uc003jjq.3_Intron|SPEF2_uc003jjp.1_Intron	NM_024867	NP_079143			KPL2 protein isoform 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
SPEF2	79925	broad.mit.edu	37	5	35792435	35792435	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35792435A>G	uc003jjo.2	+						SPEF2_uc003jjp.1_Intron|SPEF2_uc003jjr.2_Intron	NM_024867	NP_079143			KPL2 protein isoform 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A1	133688	broad.mit.edu	37	5	35957483	35957483	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:35957483C>T	uc003jjv.1	-	5	1039	c.882G>A	c.(880-882)GGG>GGA	p.G294G	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.G294G|UGT3A1_uc011cor.1_Silent_p.G260G	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	294	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A2	167127	broad.mit.edu	37	5	36035842	36035842	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36035842A>G	uc003jjz.1	-	7	1623	c.1530T>C	c.(1528-1530)GCT>GCC	p.A510A	UGT3A2_uc011cos.1_Silent_p.A476A|UGT3A2_uc011cot.1_Silent_p.A208A	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	510	Cytoplasmic (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A2	167127	broad.mit.edu	37	5	36038130	36038130	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36038130A>G	uc003jjz.1	-						UGT3A2_uc011cos.1_Intron|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574			UDP glycosyltransferase 3 family, polypeptide A2							integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
UGT3A2	167127	broad.mit.edu	37	5	36064364	36064364	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36064364A>G	uc003jjz.1	-	2	276	c.183T>C	c.(181-183)GGT>GGC	p.G61G	UGT3A2_uc011cos.1_Intron|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	61	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	36985832	36985832	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36985832T>C	uc003jkl.3	+	10	3049	c.2550T>C	c.(2548-2550)AGT>AGC	p.S850S	NIPBL_uc003jkk.3_Silent_p.S850S|NIPBL_uc003jkm.1_Silent_p.S729S	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	850					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37024793	37024793	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37024793G>A	uc003jkl.3	+	30	6180	c.5681G>A	c.(5680-5682)CGC>CAC	p.R1894H	NIPBL_uc003jkk.3_Missense_Mutation_p.R1894H	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1894					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
WDR70	55100	broad.mit.edu	37	5	37703147	37703147	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37703147T>C	uc003jkv.2	+	13	1432	c.1374T>C	c.(1372-1374)CGT>CGC	p.R458R		NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	WD repeat domain 70	458	WD 6.									ovary(1)|central_nervous_system(1)	2	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)															---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38407115	38407115	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38407115A>G	uc003jlc.1	+	8	1338	c.1014A>G	c.(1012-1014)ATA>ATG	p.I338M	EGFLAM_uc003jlb.1_Missense_Mutation_p.I338M|EGFLAM_uc003jle.1_Missense_Mutation_p.I104M|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	338						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38464058	38464058	+	Silent	SNP	G	A	A	rs17855226		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38464058G>A	uc003jlc.1	+	23	3348	c.3024G>A	c.(3022-3024)GGG>GGA	p.G1008G	EGFLAM_uc003jlb.1_Silent_p.G1000G|EGFLAM_uc003jle.1_Silent_p.G766G|EGFLAM_uc003jlf.1_Silent_p.G366G|EGFLAM_uc003jlg.1_Silent_p.G143G|EGFLAM_uc003jlh.1_Silent_p.G90G	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	1008	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
LIFR	3977	broad.mit.edu	37	5	38506631	38506631	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38506631A>G	uc010ive.1	-	8	1427	c.1095T>C	c.(1093-1095)CGT>CGC	p.R365R	LIFR_uc003jli.2_Silent_p.R365R	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	365	Fibronectin type-III 2.|Extracellular (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)							T	PLAG1	salivary adenoma								---	---	---	---
DAB2	1601	broad.mit.edu	37	5	39376963	39376963	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39376963T>C	uc003jlx.2	-	12	2457	c.1926A>G	c.(1924-1926)CCA>CCG	p.P642P	DAB2_uc003jlw.2_Silent_p.P621P	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	642					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)													OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DAB2	1601	broad.mit.edu	37	5	39377133	39377133	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39377133T>C	uc003jlx.2	-	12	2287	c.1756A>G	c.(1756-1758)ACA>GCA	p.T586A	DAB2_uc003jlw.2_Missense_Mutation_p.T565A	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	586					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)													OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
HEATR7B2	133558	broad.mit.edu	37	5	41015568	41015568	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41015568T>G	uc003jmj.3	-	29	3387	c.2897A>C	c.(2896-2898)GAA>GCA	p.E966A	HEATR7B2_uc003jmi.3_Missense_Mutation_p.E521A	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	966	HEAT 10.						binding			ovary(6)|central_nervous_system(2)	8																		---	---	---	---
FBXO4	26272	broad.mit.edu	37	5	41927177	41927177	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41927177T>C	uc003jmq.2	+	2	308	c.252T>C	c.(250-252)AGT>AGC	p.S84S	FBXO4_uc003jmp.2_Silent_p.S84S|FBXO4_uc003jmr.2_Silent_p.S84S	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	84	F-box.				positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)																---	---	---	---
ZNF131	7690	broad.mit.edu	37	5	43161820	43161820	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43161820A>G	uc011cpw.1	+	5	877	c.841A>G	c.(841-843)AAA>GAA	p.K281E	ZNF131_uc010ivl.1_Missense_Mutation_p.K247E|ZNF131_uc003jnj.3_Missense_Mutation_p.K2E|ZNF131_uc003jnk.2_Missense_Mutation_p.K247E|ZNF131_uc003jnn.3_Missense_Mutation_p.K2E|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	281	C2H2-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
NNT	23530	broad.mit.edu	37	5	43644365	43644365	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43644365T>C	uc003joe.2	+	8	1291	c.1036T>C	c.(1036-1038)TTA>CTA	p.L346L	NNT_uc003jof.2_Silent_p.L346L	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	346	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)													---	---	---	---
MRPS30	10884	broad.mit.edu	37	5	44811164	44811164	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:44811164C>T	uc003joh.2	+	2	693	c.655C>T	c.(655-657)CGT>TGT	p.R219C	MRPS30_uc003joi.1_RNA	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	219					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)																	---	---	---	---
EMB	133418	broad.mit.edu	37	5	49699039	49699039	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:49699039A>G	uc003jom.2	-	6	1099	c.850T>C	c.(850-852)TAC>CAC	p.Y284H	EMB_uc010ivq.2_Missense_Mutation_p.Y78H|EMB_uc003jol.2_Missense_Mutation_p.Y215H|EMB_uc011cpy.1_Missense_Mutation_p.Y234H|EMB_uc010ivr.2_Missense_Mutation_p.Y230H	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	284	Cytoplasmic (Potential).					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)																---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50055574	50055574	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50055574T>C	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
NDUFS4	4724	broad.mit.edu	37	5	52856488	52856488	+	5'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52856488G>A	uc003jpe.2	+	1						NM_002495	NP_002486			NADH dehydrogenase (ubiquinone) Fe-S protein 4						brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)	1		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)													---	---	---	---
DHX29	54505	broad.mit.edu	37	5	54569171	54569171	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54569171T>C	uc003jpx.2	-	17	2845	c.2725A>G	c.(2725-2727)ACC>GCC	p.T909A	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	909	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)																---	---	---	---
DHX29	54505	broad.mit.edu	37	5	54591220	54591220	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54591220T>C	uc003jpx.2	-	5	758	c.638A>G	c.(637-639)GAC>GGC	p.D213G	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	213							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)																---	---	---	---
ANKRD55	79722	broad.mit.edu	37	5	55407612	55407612	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55407612A>G	uc003jqu.2	-						ANKRD55_uc003jqt.2_Intron	NM_024669	NP_078945			ankyrin repeat domain 55 isoform 1											skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)																---	---	---	---
GPBP1	65056	broad.mit.edu	37	5	56509990	56509990	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:56509990T>C	uc003jrh.3	+	3	1307	c.33T>C	c.(31-33)CTT>CTC	p.L11L	GPBP1_uc010iwg.2_Silent_p.L11L|GPBP1_uc003jri.3_Intron|GPBP1_uc003jrj.3_Silent_p.L11L|GPBP1_uc003jrk.3_Silent_p.L11L	NM_022913	NP_075064	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1 isoform 1	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			large_intestine(1)|central_nervous_system(1)	2		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)														---	---	---	---
KIF2A	3796	broad.mit.edu	37	5	61659541	61659541	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:61659541G>A	uc003jsy.3	+	14	1593	c.1282G>A	c.(1282-1284)GCA>ACA	p.A428T	KIF2A_uc003jsz.3_Missense_Mutation_p.A428T|KIF2A_uc010iwp.2_Missense_Mutation_p.A409T|KIF2A_uc003jsx.3_Missense_Mutation_p.A408T|KIF2A_uc010iwq.2_Missense_Mutation_p.A231T	NM_004520	NP_004511	O00139	KIF2A_HUMAN	kinesin heavy chain member 2 isoform 1	428	Kinesin-motor.				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)														---	---	---	---
IPO11	51194	broad.mit.edu	37	5	61923155	61923155	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:61923155A>G	uc003jtc.2	+	30					IPO11_uc011cqr.1_3'UTR|IPO11_uc010iwr.2_3'UTR|IPO11_uc003jte.2_3'UTR	NM_016338	NP_057422			Ran binding protein 11 isoform 2							cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)														---	---	---	---
HTR1A	3350	broad.mit.edu	37	5	63256867	63256867	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63256867C>T	uc011cqt.1	-	1	680	c.680G>A	c.(679-681)CGC>CAC	p.R227H		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	227	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity	p.R227H(1)		ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)													---	---	---	---
RNF180	285671	broad.mit.edu	37	5	63509837	63509837	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63509837A>G	uc003jti.2	+	4	794	c.684A>G	c.(682-684)TCA>TCG	p.S228S	RNF180_uc003jth.3_Silent_p.S228S|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	228	Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)														---	---	---	---
RGS7BP	401190	broad.mit.edu	37	5	63803674	63803674	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:63803674A>G	uc003jtj.2	+	2	302	c.302A>G	c.(301-303)CAG>CGG	p.Q101R		NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	101					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)														---	---	---	---
PPWD1	23398	broad.mit.edu	37	5	64879030	64879030	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64879030A>G	uc003jtv.3	+	8	1523	c.1516A>G	c.(1516-1518)AAA>GAA	p.K506E	PPWD1_uc011cqv.1_Missense_Mutation_p.K476E|PPWD1_uc011cqw.1_Missense_Mutation_p.K350E	NM_015342	NP_056157	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat	506	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)														---	---	---	---
NLN	57486	broad.mit.edu	37	5	65084052	65084052	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65084052A>G	uc003juf.2	+	8	1182	c.1066A>G	c.(1066-1068)ATC>GTC	p.I356V	NLN_uc003jue.2_Missense_Mutation_p.I356V|NLN_uc003jug.2_Missense_Mutation_p.I185V|NLN_uc010iww.2_Missense_Mutation_p.I51V	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	356					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)														---	---	---	---
ERBB2IP	55914	broad.mit.edu	37	5	65324153	65324153	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65324153G>A	uc003juk.1	+	14	1496	c.1188G>A	c.(1186-1188)ATG>ATA	p.M396I	ERBB2IP_uc003juh.1_Missense_Mutation_p.M396I|ERBB2IP_uc003jui.1_Missense_Mutation_p.M396I|ERBB2IP_uc003juj.1_Missense_Mutation_p.M396I|ERBB2IP_uc011cqx.1_Missense_Mutation_p.M396I|ERBB2IP_uc011cqy.1_Missense_Mutation_p.M396I|ERBB2IP_uc011cqz.1_Missense_Mutation_p.M396I|ERBB2IP_uc010iwx.1_Missense_Mutation_p.M396I|ERBB2IP_uc003jul.1_Missense_Mutation_p.M396I	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	396	LRR 17.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)														---	---	---	---
ERBB2IP	55914	broad.mit.edu	37	5	65350643	65350643	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65350643G>A	uc003juk.1	+	21	3805	c.3497G>A	c.(3496-3498)CGG>CAG	p.R1166Q	ERBB2IP_uc003jui.1_Missense_Mutation_p.R1166Q|ERBB2IP_uc003juj.1_Missense_Mutation_p.R1166Q|ERBB2IP_uc011cqx.1_Missense_Mutation_p.R1166Q|ERBB2IP_uc011cqy.1_Missense_Mutation_p.R1166Q|ERBB2IP_uc011cqz.1_Intron|ERBB2IP_uc010iwx.1_Missense_Mutation_p.R1162Q|ERBB2IP_uc003jul.1_Missense_Mutation_p.R1162Q	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	1166					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)														---	---	---	---
CD180	4064	broad.mit.edu	37	5	66478818	66478818	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66478818A>G	uc003juy.2	-	3	2001	c.1853T>C	c.(1852-1854)CTA>CCA	p.L618P		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	618	Extracellular (Potential).|LRRCT.				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)														---	---	---	---
CD180	4064	broad.mit.edu	37	5	66479818	66479818	+	Missense_Mutation	SNP	G	A	A	rs140099362		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66479818G>A	uc003juy.2	-	3	1001	c.853C>T	c.(853-855)CGC>TGC	p.R285C		NM_005582	NP_005573	Q99467	CD180_HUMAN	CD180 molecule precursor	285	Extracellular (Potential).|LRR 8.				inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			ovary(1)	1		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)														---	---	---	---
RAD17	5884	broad.mit.edu	37	5	68687758	68687758	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68687758A>G	uc003jwo.2	+	10	1202	c.1140A>G	c.(1138-1140)GAA>GAG	p.E380E	RAD17_uc003jwg.2_Silent_p.E369E|RAD17_uc003jwh.2_Silent_p.E369E|RAD17_uc003jwi.2_Silent_p.E369E|RAD17_uc003jwj.2_Silent_p.E369E|RAD17_uc003jwk.2_Silent_p.E369E|RAD17_uc003jwl.2_Silent_p.E369E|RAD17_uc003jwm.2_Silent_p.E204E|RAD17_uc003jwn.2_Silent_p.E283E|RAD17_uc003jwp.2_5'Flank	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	380					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)									Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					---	---	---	---
MARVELD2	153562	broad.mit.edu	37	5	68728430	68728430	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:68728430A>G	uc003jwq.2	+	4	1318	c.1259A>G	c.(1258-1260)AAA>AGA	p.K420R	MARVELD2_uc010ixf.2_Missense_Mutation_p.K408R|MARVELD2_uc003jwr.1_Missense_Mutation_p.K420R|MARVELD2_uc003jws.1_RNA	NM_001038603	NP_001033692	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2 isoform 1	420	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane|tight junction					0		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)														---	---	---	---
ZNF366	167465	broad.mit.edu	37	5	71756026	71756026	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:71756026G>A	uc003kce.1	-	2	1484	c.1298C>T	c.(1297-1299)CCG>CTG	p.P433L		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	433	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)														---	---	---	---
TNPO1	3842	broad.mit.edu	37	5	72173153	72173153	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:72173153A>G	uc003kck.3	+	9	1047	c.900A>G	c.(898-900)GTA>GTG	p.V300V	TNPO1_uc011csi.1_RNA|TNPO1_uc011csj.1_Silent_p.V250V|TNPO1_uc003kch.2_Silent_p.V292V|TNPO1_uc003kci.3_Silent_p.V292V|TNPO1_uc003kcg.3_Silent_p.V292V	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	300					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)														---	---	---	---
RGNEF	64283	broad.mit.edu	37	5	73048780	73048780	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:73048780G>A	uc011csq.1	+	3	239	c.228G>A	c.(226-228)TCG>TCA	p.S76S	RGNEF_uc003kcx.2_Silent_p.S76S|RGNEF_uc003kcy.1_Silent_p.S76S|RGNEF_uc010izf.2_Silent_p.S76S	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	76					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)														---	---	---	---
ARSB	411	broad.mit.edu	37	5	78076471	78076471	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78076471A>G	uc003kfq.2	-	8	2637	c.1351T>C	c.(1351-1353)TTC>CTC	p.F451L		NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	451					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)														---	---	---	---
BHMT	635	broad.mit.edu	37	5	78423758	78423758	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78423758G>A	uc003kfu.3	+	7	1094	c.989G>A	c.(988-990)AGC>AAC	p.S330N	BHMT_uc011cti.1_Missense_Mutation_p.S177N	NM_001713	NP_001704	Q93088	BHMT1_HUMAN	betaine-homocysteine methyltransferase	330					protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)													---	---	---	---
JMY	133746	broad.mit.edu	37	5	78610597	78610597	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:78610597A>G	uc003kfx.3	+	9	3102	c.2582A>G	c.(2581-2583)CAC>CGC	p.H861R	JMY_uc003kfw.1_Missense_Mutation_p.H507R	NM_152405	NP_689618	Q8N9B5	JMY_HUMAN	junction-mediating and regulatory protein	861					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity				0		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)														---	---	---	---
CMYA5	202333	broad.mit.edu	37	5	79031641	79031641	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79031641C>T	uc003kgc.2	+	2	7125	c.7053C>T	c.(7051-7053)ATC>ATT	p.I2351I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2351						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)														---	---	---	---
CMYA5	202333	broad.mit.edu	37	5	79034494	79034494	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79034494T>A	uc003kgc.2	+	2	9978	c.9906T>A	c.(9904-9906)TAT>TAA	p.Y3302*		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3302						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)														---	---	---	---
CMYA5	202333	broad.mit.edu	37	5	79095361	79095361	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79095361T>C	uc003kgc.2	+	13	12204	c.12132T>C	c.(12130-12132)CCT>CCC	p.P4044P		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	4044	B30.2/SPRY.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)														---	---	---	---
ZFYVE16	9765	broad.mit.edu	37	5	79770525	79770525	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79770525C>G	uc003kgr.3	+	18	4639	c.4337C>G	c.(4336-4338)ACT>AGT	p.T1446S	ZFYVE16_uc003kgq.3_Missense_Mutation_p.T1446S|ZFYVE16_uc003kgs.3_Missense_Mutation_p.T1446S|ZFYVE16_uc003kgt.3_Missense_Mutation_p.T534S|ZFYVE16_uc003kgu.3_Missense_Mutation_p.T198S	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1446					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)														---	---	---	---
MSH3	4437	broad.mit.edu	37	5	80109433	80109433	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80109433G>A	uc003kgz.2	+	20	2939	c.2686G>A	c.(2686-2688)GGA>AGA	p.G896R		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	896	ATP (Potential).				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)									MMR					---	---	---	---
RASGRF2	5924	broad.mit.edu	37	5	80503095	80503095	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80503095T>A	uc003kha.1	+	21	2998	c.2998T>A	c.(2998-3000)TCC>ACC	p.S1000T	RNU5E_uc011cto.1_Intron|RASGRF2_uc011ctn.1_RNA	NM_006909	NP_008840	O14827	RGRF2_HUMAN	Ras protein-specific guanine	1000					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)														---	---	---	---
ZCCHC9	84240	broad.mit.edu	37	5	80607037	80607037	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80607037T>A	uc003khj.2	+	5	769	c.636T>A	c.(634-636)GGT>GGA	p.G212G	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Silent_p.G212G|ZCCHC9_uc003khi.2_Silent_p.G212G	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	212	CCHC-type 4.						nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)														---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82817461	82817461	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82817461C>T	uc003kii.3	+	7	3692	c.3336C>T	c.(3334-3336)CAC>CAT	p.H1112H	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.H1112H|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1112	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82832848	82832848	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82832848A>G	uc003kii.3	+	8	4382	c.4026A>G	c.(4024-4026)GTA>GTG	p.V1342V	VCAN_uc003kij.3_Silent_p.V355V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.V6V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1342	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82835440	82835440	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82835440C>T	uc003kii.3	+	8	6974	c.6618C>T	c.(6616-6618)TTC>TTT	p.F2206F	VCAN_uc003kij.3_Silent_p.F1219F|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.F870F	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2206	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
EDIL3	10085	broad.mit.edu	37	5	83360623	83360623	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:83360623T>C	uc003kio.1	-	8	1267	c.848A>G	c.(847-849)AAC>AGC	p.N283S	EDIL3_uc003kip.1_Missense_Mutation_p.N273S|EDIL3_uc011ctt.1_Missense_Mutation_p.N60S	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	283	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)														---	---	---	---
TMEM161B	153396	broad.mit.edu	37	5	87536644	87536644	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87536644T>C	uc003kjc.2	-	2	218	c.93A>G	c.(91-93)CTA>CTG	p.L31L	TMEM161B_uc011cty.1_Silent_p.L20L|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctz.1_Intron	NM_153354	NP_699185	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	31						integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89949384	89949384	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89949384C>T	uc003kju.2	+	20	4089	c.3993C>T	c.(3991-3993)ACC>ACT	p.T1331T	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1331	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
MCTP1	79772	broad.mit.edu	37	5	94288931	94288931	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94288931A>G	uc003kkx.2	-	3	973	c.973T>C	c.(973-975)TAT>CAT	p.Y325H	MCTP1_uc003kkv.2_Missense_Mutation_p.Y104H|MCTP1_uc003kkw.2_Missense_Mutation_p.Y104H|MCTP1_uc003kkz.2_5'UTR	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	325	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)														---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94859446	94859446	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94859446T>C	uc003klb.2	-	17	1815	c.1545A>G	c.(1543-1545)GGA>GGG	p.G515G	TTC37_uc010jbf.1_Silent_p.G467G	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	515	TPR 8.						binding			ovary(3)|pancreas(1)	4																		---	---	---	---
ARSK	153642	broad.mit.edu	37	5	94927320	94927320	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94927320A>G	uc003kld.2	+	6	1245	c.1087A>G	c.(1087-1089)ACC>GCC	p.T363A	ARSK_uc010jbg.2_Missense_Mutation_p.T204A|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	363						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)														---	---	---	---
ELL2	22936	broad.mit.edu	37	5	95249473	95249473	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:95249473A>G	uc003klr.3	-	4	831	c.481_splice	c.e4+1	p.G161_splice		NM_012081	NP_036213			elongation factor, RNA polymerase II, 2						regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)														---	---	---	---
LNPEP	4012	broad.mit.edu	37	5	96315402	96315402	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96315402G>A	uc003kmv.1	+	2	1094	c.580G>A	c.(580-582)GTG>ATG	p.V194M	LNPEP_uc003kmw.1_Missense_Mutation_p.V180M	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	194	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)														---	---	---	---
LNPEP	4012	broad.mit.edu	37	5	96315595	96315595	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:96315595C>T	uc003kmv.1	+	2	1287	c.773C>T	c.(772-774)ACG>ATG	p.T258M	LNPEP_uc003kmw.1_Missense_Mutation_p.T244M	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	258	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)														---	---	---	---
CHD1	1105	broad.mit.edu	37	5	98209302	98209302	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:98209302C>T	uc003knf.2	-	25	3714	c.3566G>A	c.(3565-3567)CGA>CAA	p.R1189Q	CHD1_uc010jbn.2_5'UTR	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1189					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)													---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101726676	101726676	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101726676A>G	uc003knn.2	-						SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Intron|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759			solute carrier organic anion transporter family,							integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
PPIP5K2	23262	broad.mit.edu	37	5	102494895	102494895	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102494895A>G	uc003kod.3	+	17	2302	c.1783A>G	c.(1783-1785)ATG>GTG	p.M595V	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.M595V	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	595					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2																		---	---	---	---
MAN2A1	4124	broad.mit.edu	37	5	109181585	109181585	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:109181585T>C	uc003kou.1	+	18	3683	c.2720T>C	c.(2719-2721)CTG>CCG	p.L907P		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	907	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)														---	---	---	---
SLC25A46	91137	broad.mit.edu	37	5	110096994	110096994	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110096994C>T	uc003koz.2	+	8	836	c.769C>T	c.(769-771)CGA>TGA	p.R257*	SLC25A46_uc011cvi.1_Nonsense_Mutation_p.R166*	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	257					transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)														---	---	---	---
SLC25A46	91137	broad.mit.edu	37	5	110097241	110097241	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110097241A>G	uc003koz.2	+	8	1083	c.1016A>G	c.(1015-1017)CAC>CGC	p.H339R	SLC25A46_uc011cvi.1_Missense_Mutation_p.H248R	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	339	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)														---	---	---	---
WDR36	134430	broad.mit.edu	37	5	110445992	110445992	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110445992C>T	uc003kpd.2	+	13	1716	c.1599C>T	c.(1597-1599)GGC>GGT	p.G533G	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	533					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)														---	---	---	---
WDR36	134430	broad.mit.edu	37	5	110462497	110462497	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110462497G>T	uc003kpd.2	+	23	2889	c.2772G>T	c.(2770-2772)CAG>CAT	p.Q924H	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	924					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)														---	---	---	---
APC	324	broad.mit.edu	37	5	112102935	112102935	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112102935A>G	uc010jby.2	+	4	650	c.270A>G	c.(268-270)AAA>AAG	p.K90K	APC_uc011cvt.1_Silent_p.K100K|APC_uc003kpz.3_Silent_p.K90K|APC_uc003kpy.3_Silent_p.K90K|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	90	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---
APC	324	broad.mit.edu	37	5	112176628	112176628	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112176628A>G	uc010jby.2	+	16	5717	c.5337A>G	c.(5335-5337)ATA>ATG	p.I1779M	APC_uc011cvt.1_Missense_Mutation_p.I1761M|APC_uc003kpz.3_Missense_Mutation_p.I1779M|APC_uc003kpy.3_Missense_Mutation_p.I1779M|APC_uc010jbz.2_Missense_Mutation_p.I1496M|APC_uc010jca.2_Missense_Mutation_p.I1079M	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1779	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)			12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			---	---	---	---
REEP5	7905	broad.mit.edu	37	5	112222733	112222733	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112222733C>T	uc003kqe.1	-	4	643	c.499G>A	c.(499-501)GCA>ACA	p.A167T	SRP19_uc011cvu.1_Intron|SRP19_uc011cvv.1_Intron|REEP5_uc011cvw.1_Missense_Mutation_p.A140T|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_RNA	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	167						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)														---	---	---	---
YTHDC2	64848	broad.mit.edu	37	5	112915375	112915375	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112915375T>C	uc003kqn.2	+	24	3520	c.3337T>C	c.(3337-3339)TTC>CTC	p.F1113L		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1113							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)														---	---	---	---
TRIM36	55521	broad.mit.edu	37	5	114469592	114469592	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114469592C>T	uc003kqs.2	-	8	2008	c.1499G>A	c.(1498-1500)AGC>AAC	p.S500N	TRIM36_uc011cwc.1_Missense_Mutation_p.S488N|TRIM36_uc003kqt.2_Missense_Mutation_p.S345N	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	500	Fibronectin type-III.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)														---	---	---	---
PGGT1B	5229	broad.mit.edu	37	5	114572137	114572137	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114572137A>G	uc003kqw.3	-	5	583	c.562T>C	c.(562-564)TGG>CGG	p.W188R	PGGT1B_uc003kqx.3_Missense_Mutation_p.W65R|PGGT1B_uc010jch.2_Missense_Mutation_p.W188R	NM_005023	NP_005014	P53609	PGTB1_HUMAN	geranylgeranyltransferase type 1 beta	188					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity				0		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)													---	---	---	---
TMED7-TICAM2	100302736	broad.mit.edu	37	5	114916287	114916287	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114916287T>C	uc003krd.2	-	4	1673	c.667A>G	c.(667-669)AAA>GAA	p.K223E	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.K392E|TICAM2_uc003krc.2_Missense_Mutation_p.K223E	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	223	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0																		---	---	---	---
TMED7-TICAM2	100302736	broad.mit.edu	37	5	114916505	114916505	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:114916505T>C	uc003krd.2	-	4	1455	c.449A>G	c.(448-450)AAT>AGT	p.N150S	TMED7-TICAM2_uc003kre.2_Missense_Mutation_p.N319S|TICAM2_uc003krc.2_Missense_Mutation_p.N150S	NM_021649	NP_067681	Q86XR7	TCAM2_HUMAN	toll-like receptor adaptor molecule 2	150	TIR.				I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	Golgi apparatus|intrinsic to membrane|plasma membrane	protein binding|transmembrane receptor activity				0																		---	---	---	---
SEMA6A	57556	broad.mit.edu	37	5	115813736	115813736	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115813736C>T	uc010jck.2	-	14	2251	c.1542G>A	c.(1540-1542)CGG>CGA	p.R514R	SEMA6A_uc003krx.3_Silent_p.R514R|SEMA6A_uc003krw.3_Silent_p.R46R|SEMA6A_uc010jcj.2_Silent_p.R58R	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	514	Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118485923	118485923	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118485923G>A	uc003ksd.2	+	18	4582	c.4401G>A	c.(4399-4401)AAG>AAA	p.K1467K	DMXL1_uc010jcl.1_Silent_p.K1467K	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1467										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
CEP120	153241	broad.mit.edu	37	5	122717893	122717893	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122717893A>G	uc003ktk.2	-	15	2097	c.2015T>C	c.(2014-2016)CTG>CCG	p.L672P	CEP120_uc011cwq.1_Missense_Mutation_p.L481P|CEP120_uc010jcz.1_Missense_Mutation_p.L646P	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	672	Potential.					centrosome				ovary(1)	1																		---	---	---	---
CEP120	153241	broad.mit.edu	37	5	122726848	122726848	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122726848C>T	uc003ktk.2	-	8	1076	c.994G>A	c.(994-996)GTG>ATG	p.V332M	CEP120_uc011cwq.1_Missense_Mutation_p.V141M|CEP120_uc010jcz.1_Missense_Mutation_p.V306M	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	332						centrosome				ovary(1)	1																		---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122911419	122911419	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122911419C>T	uc003ktm.2	+						CSNK1G3_uc003ktl.2_Intron|CSNK1G3_uc003ktn.2_Intron|CSNK1G3_uc003kto.2_Intron|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Intron	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122911547	122911547	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122911547T>C	uc003ktm.2	+	6	1282	c.563T>C	c.(562-564)TTG>TCG	p.L188S	CSNK1G3_uc003ktl.2_Missense_Mutation_p.L188S|CSNK1G3_uc003ktn.2_Missense_Mutation_p.L188S|CSNK1G3_uc003kto.2_Missense_Mutation_p.L188S|CSNK1G3_uc011cwr.1_Missense_Mutation_p.L113S|CSNK1G3_uc011cws.1_Missense_Mutation_p.L75S|CSNK1G3_uc010jda.2_Missense_Mutation_p.L188S	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	188	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
LMNB1	4001	broad.mit.edu	37	5	126156662	126156662	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126156662T>C	uc003kud.1	+	7	1589	c.1221T>C	c.(1219-1221)CGT>CGC	p.R407R	LMNB1_uc010jdb.1_RNA|LMNB1_uc011cxb.1_Silent_p.R197R	NM_005573	NP_005564	P20700	LMNB1_HUMAN	lamin B1	407	Tail.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			kidney(1)|central_nervous_system(1)	2		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127599336	127599336	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127599336C>T	uc003kuu.2	-	63	8412	c.7973G>A	c.(7972-7974)TGC>TAC	p.C2658Y		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2658	EGF-like 46; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127647035	127647035	+	Silent	SNP	G	A	A	rs147452231	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127647035G>A	uc003kuu.2	-	39	5470	c.5031C>T	c.(5029-5031)TGC>TGT	p.C1677C		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1677	EGF-like 27; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
ADAMTS19	171019	broad.mit.edu	37	5	128861990	128861990	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:128861990T>A	uc003kvb.1	+	4	909	c.909T>A	c.(907-909)CCT>CCA	p.P303P	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	303					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)														---	---	---	---
ADAMTS19	171019	broad.mit.edu	37	5	129015545	129015545	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:129015545T>G	uc003kvb.1	+	17	2577	c.2577T>G	c.(2575-2577)CAT>CAG	p.H859Q	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	859	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)														---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130928073	130928073	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130928073T>A	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvr.2_Intron|RAPGEF6_uc011cxe.1_Intron|RAPGEF6_uc010jdk.2_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
RAD50	10111	broad.mit.edu	37	5	131953957	131953957	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131953957T>G	uc003kxi.2	+	21	3747	c.3360T>G	c.(3358-3360)GAT>GAG	p.D1120E	RAD50_uc003kxh.2_Missense_Mutation_p.D981E	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1120					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)										Homologous_recombination					---	---	---	---
RAD50	10111	broad.mit.edu	37	5	131953995	131953995	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:131953995T>C	uc003kxi.2	+						RAD50_uc003kxh.2_Intron	NM_005732	NP_005723			RAD50 homolog isoform 1						DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)										Homologous_recombination					---	---	---	---
KIF3A	11127	broad.mit.edu	37	5	132070038	132070038	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132070038T>C	uc003kxo.2	-	2	293	c.139A>G	c.(139-141)ACT>GCT	p.T47A	KIF3A_uc003kxn.2_Missense_Mutation_p.T6A|KIF3A_uc011cxf.1_Missense_Mutation_p.T47A|KIF3A_uc003kxp.2_Missense_Mutation_p.T47A	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	47	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SHROOM1	134549	broad.mit.edu	37	5	132158969	132158969	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132158969C>T	uc003kxx.2	-	9	3004	c.2199G>A	c.(2197-2199)GCG>GCA	p.A733A	SHROOM1_uc003kxy.1_Silent_p.A733A	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	733	ASD2.				actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
AFF4	27125	broad.mit.edu	37	5	132220768	132220768	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132220768C>A	uc003kyd.2	-	19	3551	c.3143G>T	c.(3142-3144)AGC>ATC	p.S1048I	AFF4_uc011cxk.1_Missense_Mutation_p.S726I	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	1048					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132424147	132424147	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132424147G>A	uc003kyj.2	+	9	1318	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	346					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
HSPA4	3308	broad.mit.edu	37	5	132428415	132428415	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132428415A>G	uc003kyj.2	+	13	1865	c.1584A>G	c.(1582-1584)GAA>GAG	p.E528E		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	528					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
FSTL4	23105	broad.mit.edu	37	5	132535212	132535212	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132535212C>T	uc003kyn.1	-	16	2322	c.2104G>A	c.(2104-2106)GTC>ATC	p.V702I	FSTL4_uc003kym.1_Missense_Mutation_p.V351I	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	702						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
TCF7	6932	broad.mit.edu	37	5	133473800	133473800	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133473800A>G	uc003kyt.2	+	4	688	c.492A>G	c.(490-492)GAA>GAG	p.E164E	TCF7_uc003kyu.1_Silent_p.E49E|TCF7_uc003kyv.2_Silent_p.E49E|TCF7_uc003kyw.2_Silent_p.E49E|TCF7_uc003kyx.2_5'UTR|TCF7_uc003kyy.2_Silent_p.E49E|TCF7_uc003kyz.2_Silent_p.E49E|TCF7_uc003kza.2_Silent_p.E49E	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	164					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
TCF7	6932	broad.mit.edu	37	5	133479022	133479022	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133479022G>A	uc003kyt.2	+						TCF7_uc003kyu.1_Intron|TCF7_uc003kyv.2_Intron|TCF7_uc003kyw.2_Intron|TCF7_uc003kyx.2_Intron|TCF7_uc003kyy.2_Intron|TCF7_uc003kyz.2_Intron|TCF7_uc003kza.2_Intron|TCF7_uc003kzb.2_Intron|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193			transcription factor 7 (T-cell specific,						cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
PPP2CA	5515	broad.mit.edu	37	5	133536726	133536726	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133536726T>C	uc003kze.2	-	4	924	c.526A>G	c.(526-528)ACA>GCA	p.T176A		NM_002715	NP_002706	P67775	PP2AA_HUMAN	protein phosphatase 2, catalytic subunit, alpha	176					ceramide metabolic process|inactivation of MAPK activity|induction of apoptosis|meiosis|negative regulation of cell growth|negative regulation of epithelial to mesenchymal transition|negative regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of protein serine/threonine kinase activity|protein dephosphorylation|regulation of cell adhesion|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction|spindle pole	metal ion binding|phosphoprotein phosphatase activity			ovary(2)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Vitamin E(DB00163)													---	---	---	---
PPP2CA	5515	broad.mit.edu	37	5	133561534	133561534	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133561534T>C	uc003kze.2	-	1	417	c.19A>G	c.(19-21)ACC>GCC	p.T7A	CDKL3_uc011cxm.1_Intron|CDKL3_uc011cxn.1_Intron	NM_002715	NP_002706	P67775	PP2AA_HUMAN	protein phosphatase 2, catalytic subunit, alpha	7					ceramide metabolic process|inactivation of MAPK activity|induction of apoptosis|meiosis|negative regulation of cell growth|negative regulation of epithelial to mesenchymal transition|negative regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of protein serine/threonine kinase activity|protein dephosphorylation|regulation of cell adhesion|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction|spindle pole	metal ion binding|phosphoprotein phosphatase activity			ovary(2)|lung(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Vitamin E(DB00163)													---	---	---	---
SEC24A	10802	broad.mit.edu	37	5	133997278	133997278	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133997278T>C	uc003kzs.2	+	2	853	c.565_splice	c.e2+2	p.G189_splice	SEC24A_uc011cxu.1_Splice_Site	NM_021982	NP_068817			SEC24 related gene family, member A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SEC24A	10802	broad.mit.edu	37	5	134044487	134044487	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134044487G>A	uc003kzs.2	+	18	2924	c.2636G>A	c.(2635-2637)CGT>CAT	p.R879H	SEC24A_uc011cxu.1_Missense_Mutation_p.R643H	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	879					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
DDX46	9879	broad.mit.edu	37	5	134109545	134109545	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134109545G>A	uc003kzw.2	+	5	775	c.607G>A	c.(607-609)GAT>AAT	p.D203N	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	203	Poly-Asp.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
FBXL21	26223	broad.mit.edu	37	5	135277366	135277366	+	3'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:135277366T>C	uc010jec.1	+	5					FBXL21_uc003lbc.2_Intron	NM_012159	NP_036291			F-box and leucine-rich repeat protein 21						rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
KLHL3	26249	broad.mit.edu	37	5	137056206	137056206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137056206C>T	uc010jek.2	-	2	526	c.82G>A	c.(82-84)GTC>ATC	p.V28I	MYOT_uc011cye.1_Intron|KLHL3_uc010jem.1_Intron	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	28						cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)														---	---	---	---
PKD2L2	27039	broad.mit.edu	37	5	137271556	137271556	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137271556T>A	uc003lby.2	+	13	1798	c.1742T>A	c.(1741-1743)ATT>AAT	p.I581N	PKD2L2_uc003lbw.1_Missense_Mutation_p.I581N|PKD2L2_uc003lbx.2_Missense_Mutation_p.I480N|PKD2L2_uc011cyi.1_Missense_Mutation_p.I189N	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	581	Cytoplasmic (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
NME5	8382	broad.mit.edu	37	5	137454576	137454576	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137454576A>C	uc003lce.2	-	5	564	c.486T>G	c.(484-486)AAT>AAG	p.N162K	BRD8_uc003lcc.1_Intron	NM_003551	NP_003542	P56597	NDK5_HUMAN	non-metastatic cells 5, protein expressed in	162					anti-apoptosis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatid development|UTP biosynthetic process		ATP binding|nucleoside diphosphate kinase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
CDC23	8697	broad.mit.edu	37	5	137533902	137533902	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137533902G>A	uc003lcl.2	-	9	1029	c.998C>T	c.(997-999)ACG>ATG	p.T333M		NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	333	TPR 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
KDM3B	51780	broad.mit.edu	37	5	137727078	137727078	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137727078G>T	uc003lcy.1	+	8	1957	c.1757G>T	c.(1756-1758)GGC>GTC	p.G586V	KDM3B_uc010jew.1_Missense_Mutation_p.G242V|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	586					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11																		---	---	---	---
CTNNA1	1495	broad.mit.edu	37	5	138265055	138265055	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138265055C>T	uc003ldh.2	+						CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|CTNNA1_uc003ldl.2_Intron	NM_001903	NP_001894			catenin, alpha 1						adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)															---	---	---	---
CTNNA1	1495	broad.mit.edu	37	5	138269585	138269585	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138269585A>G	uc003ldh.2	+	18	2623	c.2528A>G	c.(2527-2529)TAC>TGC	p.Y843C	CTNNA1_uc011cyx.1_Missense_Mutation_p.Y740C|CTNNA1_uc011cyy.1_Missense_Mutation_p.Y720C|CTNNA1_uc003ldi.2_Missense_Mutation_p.Y541C|CTNNA1_uc003ldj.2_3'UTR|CTNNA1_uc003ldl.2_Missense_Mutation_p.Y473C	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	843					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)															---	---	---	---
SLC23A1	9963	broad.mit.edu	37	5	138714371	138714371	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138714371C>T	uc003leh.2	-	10	1173	c.1076G>A	c.(1075-1077)GGC>GAC	p.G359D	SLC23A1_uc003leg.2_Missense_Mutation_p.G363D	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	359	Helical; (Potential).				brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)													---	---	---	---
PSD2	84249	broad.mit.edu	37	5	139193808	139193808	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139193808C>T	uc003leu.1	+	4	1080	c.875C>T	c.(874-876)TCG>TTG	p.S292L		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	292	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139884751	139884751	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:139884751T>C	uc003lfs.1	+	17	3319	c.3195T>C	c.(3193-3195)GGT>GGC	p.G1065G	ANKHD1_uc003lfq.1_Silent_p.G1084G|ANKHD1_uc003lfr.2_Silent_p.G1065G|ANKHD1_uc003lft.1_Silent_p.G276G|ANKHD1_uc003lfu.1_Silent_p.G545G|ANKHD1_uc003lfv.1_Silent_p.G142G	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1065						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA4	56144	broad.mit.edu	37	5	140188651	140188651	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140188651T>C	uc003lhi.2	+	1	1980	c.1879T>C	c.(1879-1881)TAC>CAC	p.Y627H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.Y627H|PCDHA4_uc011daa.1_Missense_Mutation_p.Y627H	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	627	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA5	56143	broad.mit.edu	37	5	140203141	140203141	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140203141G>A	uc003lhl.2	+	1	1781	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R594H|PCDHA5_uc003lhj.1_Missense_Mutation_p.R594H	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	594	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA5	56143	broad.mit.edu	37	5	140203465	140203465	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140203465C>T	uc003lhl.2	+	1	2105	c.2105C>T	c.(2104-2106)GCC>GTC	p.A702V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.A702V|PCDHA5_uc003lhj.1_Missense_Mutation_p.A702V	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	702	Helical; (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA7	56141	broad.mit.edu	37	5	140214272	140214272	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140214272T>C	uc003lhq.2	+	1	304	c.304T>C	c.(304-306)TGC>CGC	p.C102R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.C102R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	102	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140228384	140228384	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140228384T>C	uc003lhu.2	+	1	1028	c.304T>C	c.(304-306)TGC>CGC	p.C102R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.C102R	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	102	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140229555	140229555	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140229555A>G	uc003lhu.2	+	1	2199	c.1475A>G	c.(1474-1476)TAC>TGC	p.Y492C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.Y492C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	492	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140229744	140229744	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140229744T>C	uc003lhu.2	+	1	2388	c.1664T>C	c.(1663-1665)GTG>GCG	p.V555A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.V555A	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	555	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140230117	140230117	+	Silent	SNP	G	A	A	rs140380568	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140230117G>A	uc003lhu.2	+	1	2761	c.2037G>A	c.(2035-2037)TCG>TCA	p.S679S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.S679S	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	679	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA10	56139	broad.mit.edu	37	5	140236179	140236179	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140236179A>T	uc003lhx.2	+	1	546	c.546A>T	c.(544-546)ATA>ATT	p.I182I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.I182I|PCDHA10_uc011dad.1_Silent_p.I182I	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	182	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140249416	140249416	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140249416A>T	uc003lia.2	+	1	1586	c.728A>T	c.(727-729)GAT>GTT	p.D243V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.D243V	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	243	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA11	56138	broad.mit.edu	37	5	140250295	140250295	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140250295C>T	uc003lia.2	+	1	2465	c.1607C>T	c.(1606-1608)GCG>GTG	p.A536V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A536V	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	536	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA13	56136	broad.mit.edu	37	5	140263420	140263420	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140263420T>C	uc003lif.2	+	1	1567	c.1567T>C	c.(1567-1569)TTG>CTG	p.L523L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L523L|PCDHA13_uc003lid.2_Silent_p.L523L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	523	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHA13	56136	broad.mit.edu	37	5	140263984	140263984	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140263984T>C	uc003lif.2	+	1	2131	c.2131T>C	c.(2131-2133)TTG>CTG	p.L711L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L711L|PCDHA13_uc003lid.2_Silent_p.L711L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	711	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC1	56135	broad.mit.edu	37	5	140306707	140306707	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140306707T>C	uc003lih.2	+	1	406	c.230T>C	c.(229-231)GTC>GCC	p.V77A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.V77A	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	77	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB5	26167	broad.mit.edu	37	5	140516540	140516540	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140516540C>T	uc003liq.2	+	1	1741	c.1524C>T	c.(1522-1524)GAC>GAT	p.D508D		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	508	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB7	56129	broad.mit.edu	37	5	140554005	140554005	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140554005G>A	uc003lit.2	+	1	1763	c.1589G>A	c.(1588-1590)CGC>CAC	p.R530H		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	530	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB16	57717	broad.mit.edu	37	5	140562720	140562720	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140562720T>C	uc003liv.2	+	1	1741	c.586T>C	c.(586-588)TTG>CTG	p.L196L	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	196	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB16	57717	broad.mit.edu	37	5	140564077	140564077	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140564077G>C	uc003liv.2	+	1	3098	c.1943G>C	c.(1942-1944)GGC>GCC	p.G648A	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	648	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB9	56127	broad.mit.edu	37	5	140568285	140568285	+	Missense_Mutation	SNP	G	A	A	rs17844522		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140568285G>A	uc003liw.1	+	3	1394	c.1394G>A	c.(1393-1395)AGC>AAC	p.S465N		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	465	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB9	56127	broad.mit.edu	37	5	140568579	140568579	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140568579A>G	uc003liw.1	+	3	1688	c.1688A>G	c.(1687-1689)TAC>TGC	p.Y563C		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	563	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB10	56126	broad.mit.edu	37	5	140573462	140573462	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140573462A>C	uc003lix.2	+	1	1511	c.1337A>C	c.(1336-1338)GAC>GCC	p.D446A		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	446	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB12	56124	broad.mit.edu	37	5	140590145	140590145	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140590145G>A	uc003liz.2	+	1	1855	c.1666G>A	c.(1666-1668)GAC>AAC	p.D556N	PCDHB12_uc011dak.1_Missense_Mutation_p.D219N	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	556	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGA3	56112	broad.mit.edu	37	5	140725675	140725675	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140725675A>G	uc003ljm.1	+	1	2075	c.2075A>G	c.(2074-2076)TAC>TGC	p.Y692C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.Y452C|PCDHGA3_uc011dap.1_Missense_Mutation_p.Y692C	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	692	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA4	56111	broad.mit.edu	37	5	140735157	140735157	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140735157A>G	uc003ljq.1	+	1	390	c.390A>G	c.(388-390)CCA>CCG	p.P130P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Silent_p.P130P	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	130	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB3	56102	broad.mit.edu	37	5	140751421	140751421	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140751421T>C	uc003ljw.1	+	1	1460	c.1460T>C	c.(1459-1461)GTC>GCC	p.V487A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.V487A|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	487	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA8	9708	broad.mit.edu	37	5	140772702	140772702	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140772702A>G	uc003lkd.1	+	1	1220	c.322A>G	c.(322-324)ACC>GCC	p.T108A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.T108A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	108	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA9	56107	broad.mit.edu	37	5	140782733	140782733	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140782733A>G	uc003lkh.1	+	1	214	c.214A>G	c.(214-216)ACG>GCG	p.T72A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.T72A	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	72	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA9	56107	broad.mit.edu	37	5	140782869	140782869	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140782869A>G	uc003lkh.1	+	1	350	c.350A>G	c.(349-351)TAC>TGC	p.Y117C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc011dax.1_Missense_Mutation_p.Y117C	NM_018921	NP_061744	Q9Y5G4	PCDG9_HUMAN	protocadherin gamma subfamily A, 9 isoform 1	117	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA10	56106	broad.mit.edu	37	5	140794829	140794829	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140794829A>G	uc003lkl.1	+	1	2087	c.2087A>G	c.(2086-2088)TAC>TGC	p.Y696C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.Y696C|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	696	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB7	56099	broad.mit.edu	37	5	140797840	140797840	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140797840A>G	uc003lkn.1	+	1	559	c.414A>G	c.(412-414)ATA>ATG	p.I138M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.I138M|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	138	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA11	56105	broad.mit.edu	37	5	140801979	140801979	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140801979A>G	uc003lkq.1	+	1	1443	c.1185A>G	c.(1183-1185)TTA>TTG	p.L395L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Silent_p.L395L|PCDHGA11_uc003lkp.1_Silent_p.L395L	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	395	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA12	26025	broad.mit.edu	37	5	140812322	140812322	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140812322G>A	uc003lkt.1	+	1	2165	c.1996G>A	c.(1996-1998)GAC>AAC	p.D666N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.D666N	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	666	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGC4	56098	broad.mit.edu	37	5	140865090	140865090	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140865090A>G	uc003lky.1	+	1	350	c.350A>G	c.(349-351)TAC>TGC	p.Y117C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.Y117C	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	117	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDH1	5097	broad.mit.edu	37	5	141243673	141243673	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141243673G>A	uc003llq.2	-	3	2340	c.2223C>T	c.(2221-2223)GCC>GCT	p.A741A	PCDH1_uc003llp.2_Silent_p.A741A|PCDH1_uc011dbf.1_Silent_p.A719A	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	741	Extracellular (Potential).|Cadherin 7.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)														---	---	---	---
PCDH1	5097	broad.mit.edu	37	5	141248257	141248257	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:141248257G>A	uc003llq.2	-	2	897	c.780C>T	c.(778-780)CGC>CGT	p.R260R	PCDH1_uc003llp.2_Silent_p.R260R|PCDH1_uc011dbf.1_Silent_p.R238R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	260	Extracellular (Potential).|Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)														---	---	---	---
YIPF5	81555	broad.mit.edu	37	5	143540084	143540084	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:143540084T>G	uc003lnk.3	-	6	1092	c.651A>C	c.(649-651)GGA>GGC	p.G217G	YIPF5_uc003lnl.3_Silent_p.G217G|YIPF5_uc010jgl.2_Silent_p.G163G	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	217	Helical; (Potential).				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)															---	---	---	---
KCTD16	57528	broad.mit.edu	37	5	143587110	143587110	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:143587110G>A	uc003lnm.1	+	3	1461	c.832_splice	c.e3+1	p.R278_splice	KCTD16_uc003lnn.1_Splice_Site_p.R278_splice	NM_020768	NP_065819			potassium channel tetramerisation domain							cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)															---	---	---	---
LARS	51520	broad.mit.edu	37	5	145493676	145493676	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145493676A>G	uc003lnx.1	-	32	3762	c.3524T>C	c.(3523-3525)GTT>GCT	p.V1175A	LARS_uc003lnw.1_Missense_Mutation_p.V333A|LARS_uc011dbq.1_Missense_Mutation_p.V1129A|LARS_uc011dbr.1_Missense_Mutation_p.V1121A|LARS_uc011dbs.1_Missense_Mutation_p.V1148A	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	1175					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)													---	---	---	---
GPR151	134391	broad.mit.edu	37	5	145895104	145895104	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145895104T>C	uc003lod.1	-	1	573	c.573A>G	c.(571-573)GTA>GTG	p.V191V		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	191	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
DPYSL3	1809	broad.mit.edu	37	5	146792252	146792252	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:146792252C>T	uc003lon.1	-	6	651	c.541_splice	c.e6-1	p.L181_splice	DPYSL3_uc003loo.2_Splice_Site_p.L295_splice	NM_001387	NP_001378			dihydropyrimidinase-like 3						axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
JAKMIP2	9832	broad.mit.edu	37	5	147019216	147019216	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147019216G>A	uc003loq.1	-	10	1891	c.1509C>T	c.(1507-1509)ATC>ATT	p.I503I	JAKMIP2_uc011dbx.1_Silent_p.I461I|JAKMIP2_uc003lor.1_Silent_p.I503I|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Silent_p.I503I	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	503	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SPINK5	11005	broad.mit.edu	37	5	147503389	147503389	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147503389T>C	uc003lox.2	+						SPINK5_uc010jgr.2_Intron|SPINK5_uc003low.2_Intron|SPINK5_uc003loy.2_Intron	NM_006846	NP_006837			serine peptidase inhibitor, Kazal type 5 isoform						anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
HTR4	3360	broad.mit.edu	37	5	147902878	147902878	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147902878A>G	uc003lpn.2	-	5	549	c.385T>C	c.(385-387)TAT>CAT	p.Y129H	HTR4_uc010jgu.1_RNA|HTR4_uc003lpi.1_Missense_Mutation_p.Y129H|HTR4_uc003lpj.1_Missense_Mutation_p.Y129H|HTR4_uc003lpk.2_Missense_Mutation_p.Y129H|HTR4_uc011dby.1_Missense_Mutation_p.Y129H|HTR4_uc003lpl.2_Missense_Mutation_p.Y129H|HTR4_uc003lpm.2_Missense_Mutation_p.Y129H|HTR4_uc010jgv.2_RNA|HTR4_uc003lpo.1_Missense_Mutation_p.Y129H	NM_000870	NP_000861	Q13639	5HT4R_HUMAN	serotonin 5-HT4 receptor isoform b	129	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)													---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148388499	148388499	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148388499C>T	uc003lpu.2	-	15	3545	c.3393G>A	c.(3391-3393)AAG>AAA	p.K1131K	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Silent_p.K775K|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Silent_p.K678K|SH3TC2_uc010jgx.2_Silent_p.K1124K	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1131	TPR 6.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148388548	148388548	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148388548A>G	uc003lpu.2	-	15	3496	c.3344T>C	c.(3343-3345)TTA>TCA	p.L1115S	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.L759S|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.L662S|SH3TC2_uc010jgx.2_Missense_Mutation_p.L1108S	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	1115	TPR 5.						binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148431762	148431762	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148431762A>G	uc003lpu.2	-	2	246	c.94T>C	c.(94-96)TGT>CGT	p.C32R	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.C32R|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_5'UTR|SH3TC2_uc003lpw.1_Missense_Mutation_p.C32R	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	32							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
ABLIM3	22885	broad.mit.edu	37	5	148617149	148617149	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148617149A>G	uc003lpy.2	+	11	1278	c.1027A>G	c.(1027-1029)AGA>GGA	p.R343G	ABLIM3_uc003lpz.1_Missense_Mutation_p.R343G|ABLIM3_uc003lqa.1_Intron|ABLIM3_uc003lqb.2_Intron|ABLIM3_uc003lqc.1_Missense_Mutation_p.R343G|ABLIM3_uc003lqd.1_Intron|ABLIM3_uc003lqf.2_Intron|ABLIM3_uc003lqe.1_Intron	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	343					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
ARHGEF37	389337	broad.mit.edu	37	5	149003693	149003693	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149003693C>T	uc003lra.1	+	10	1518	c.1454C>T	c.(1453-1455)CCC>CTC	p.P485L		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	485					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0																		---	---	---	---
ARSI	340075	broad.mit.edu	37	5	149677489	149677489	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149677489A>G	uc003lrv.2	-	2	1587	c.998T>C	c.(997-999)CTG>CCG	p.L333P		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	333						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
SYNPO	11346	broad.mit.edu	37	5	150029518	150029518	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150029518A>G	uc003lsn.2	+	3	2787	c.2413A>G	c.(2413-2415)AAG>GAG	p.K805E	SYNPO_uc003lso.3_Missense_Mutation_p.K561E|SYNPO_uc003lsp.2_Missense_Mutation_p.K561E	NM_001109974	NP_001103444	Q8N3V7	SYNPO_HUMAN	synaptopodin isoform B	805	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			large_intestine(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
TNIP1	10318	broad.mit.edu	37	5	150410293	150410293	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150410293T>C	uc003ltf.2	-	18	2481	c.1892A>G	c.(1891-1893)GAC>GGC	p.D631G	TNIP1_uc011dcn.1_Missense_Mutation_p.D149G|TNIP1_uc010jhl.2_RNA|TNIP1_uc010jhm.2_Missense_Mutation_p.D567G|TNIP1_uc010jhn.2_Missense_Mutation_p.T535A|TNIP1_uc011dco.1_3'UTR|TNIP1_uc003lth.2_RNA|TNIP1_uc003lti.2_Missense_Mutation_p.D631G|TNIP1_uc003ltg.2_Missense_Mutation_p.D578G|TNIP1_uc003ltj.2_Missense_Mutation_p.D631G|TNIP1_uc010jho.1_Intron|TNIP1_uc010jhq.1_Intron|TNIP1_uc010jhp.1_Intron|TNIP1_uc010jhr.1_Intron|TNIP1_uc003ltk.2_Intron	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	631	Pro-rich.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
ANXA6	309	broad.mit.edu	37	5	150484828	150484828	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150484828T>C	uc003ltl.1	-	24	1969	c.1817A>G	c.(1816-1818)GAC>GGC	p.D606G	ANXA6_uc011dcp.1_Missense_Mutation_p.D574G|ANXA6_uc003ltm.1_Missense_Mutation_p.D600G|ANXA6_uc003ltn.1_Missense_Mutation_p.D393G|ANXA6_uc003lto.1_Missense_Mutation_p.D193G	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	606						melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150900933	150900933	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150900933C>G	uc003lue.3	-	18	11234	c.11221G>C	c.(11221-11223)GTG>CTG	p.V3741L	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.V434L	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3741	Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
SPARC	6678	broad.mit.edu	37	5	151052748	151052748	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151052748C>T	uc003luh.2	-	3	174	c.150G>A	c.(148-150)GTG>GTA	p.V50V	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_5'UTR|SPARC_uc003lui.2_Silent_p.V50V	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	50	Asp/Glu-rich (acidic; binds calcium).				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)													---	---	---	---
G3BP1	10146	broad.mit.edu	37	5	151170481	151170481	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151170481T>C	uc003lun.2	+	4	380	c.209T>C	c.(208-210)TTC>TCC	p.F70S	G3BP1_uc010jhy.1_Missense_Mutation_p.F70S|G3BP1_uc003lum.2_Missense_Mutation_p.F70S|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	70	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)															---	---	---	---
GALNT10	55568	broad.mit.edu	37	5	153792536	153792536	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:153792536C>T	uc003lvh.2	+	10	1606	c.1474C>T	c.(1474-1476)CGT>TGT	p.R492C	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Missense_Mutation_p.R333C|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Missense_Mutation_p.R163C	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	492	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)															---	---	---	---
LARP1	23367	broad.mit.edu	37	5	154173252	154173252	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154173252A>G	uc003lvp.2	+	5	1266	c.837A>G	c.(835-837)AGA>AGG	p.R279R	LARP1_uc003lvo.2_Silent_p.R202R|LARP1_uc010jie.1_Silent_p.R74R	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	279							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154284949	154284949	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154284949T>C	uc003lvx.3	-	17	2566	c.2483A>G	c.(2482-2484)AAA>AGA	p.K828R	GEMIN5_uc011ddk.1_Missense_Mutation_p.K827R	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	828					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
KIF4B	285643	broad.mit.edu	37	5	154394631	154394631	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154394631T>C	uc010jih.1	+	1	1372	c.1212T>C	c.(1210-1212)CGT>CGC	p.R404R		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	404	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
KIF4B	285643	broad.mit.edu	37	5	154396976	154396976	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154396976C>T	uc010jih.1	+	1	3717	c.3557C>T	c.(3556-3558)GCT>GTT	p.A1186V		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1186	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
C5orf40	408263	broad.mit.edu	37	5	156769912	156769912	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156769912C>A	uc003lwu.2	-	2	821	c.633G>T	c.(631-633)GGG>GGT	p.G211G	CYFIP2_uc003lwq.2_Intron|CYFIP2_uc011ddn.1_Intron|CYFIP2_uc011ddo.1_Intron|CYFIP2_uc003lwr.2_Intron|CYFIP2_uc003lws.2_Intron|CYFIP2_uc003lwt.2_Intron|CYFIP2_uc011ddp.1_Intron	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	hypothetical protein LOC408263	211						integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)													OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SOX30	11063	broad.mit.edu	37	5	157053373	157053373	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:157053373T>A	uc003lxb.1	-	5	2579	c.2237A>T	c.(2236-2238)GAA>GTA	p.E746V	SOX30_uc003lxc.1_3'UTR|SOX30_uc011dds.1_Missense_Mutation_p.E441V	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	746					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
EBF1	1879	broad.mit.edu	37	5	158135143	158135143	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158135143G>T	uc010jip.2	-	15	1890	c.1588C>A	c.(1588-1590)CTC>ATC	p.L530I	EBF1_uc011ddw.1_Missense_Mutation_p.L398I|EBF1_uc011ddx.1_Missense_Mutation_p.L531I|EBF1_uc003lxl.3_Missense_Mutation_p.L499I	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	530	Pro/Ser/Thr-rich.				multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)					T	HMGA2	lipoma								---	---	---	---
FABP6	2172	broad.mit.edu	37	5	159659203	159659203	+	Missense_Mutation	SNP	G	A	A	rs140576066		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159659203G>A	uc003lya.1	+	2	294	c.166G>A	c.(166-168)GGG>AGG	p.G56R	FABP6_uc003lxx.1_Missense_Mutation_p.G105R|FABP6_uc003lxz.1_Missense_Mutation_p.G105R	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	56					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
SLU7	10569	broad.mit.edu	37	5	159835377	159835377	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:159835377T>C	uc003lyg.2	-	8	933	c.778A>G	c.(778-780)ATT>GTT	p.I260V		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	260					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
GABRA6	2559	broad.mit.edu	37	5	161113279	161113279	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161113279T>C	uc003lyu.2	+	2	420	c.82T>C	c.(82-84)TAC>CAC	p.Y28H		NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	28	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)										TCGA Ovarian(5;0.080)			---	---	---	---
GABRA1	2554	broad.mit.edu	37	5	161318037	161318037	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:161318037A>G	uc010jiw.2	+	9	1305	c.837A>G	c.(835-837)GTA>GTG	p.V279V	GABRA1_uc010jix.2_Silent_p.V279V|GABRA1_uc010jiy.2_Silent_p.V279V|GABRA1_uc003lyx.3_Silent_p.V279V|GABRA1_uc010jiz.2_Silent_p.V279V|GABRA1_uc010jja.2_Silent_p.V279V|GABRA1_uc010jjb.2_Silent_p.V279V	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	279	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)													---	---	---	---
NUDCD2	134492	broad.mit.edu	37	5	162886992	162886992	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:162886992T>C	uc003lze.2	-	1	152	c.65A>G	c.(64-66)TAC>TGC	p.Y22C	HMMR_uc003lzh.2_5'Flank|HMMR_uc003lzf.2_5'Flank|HMMR_uc003lzg.2_5'Flank|HMMR_uc011dem.1_5'Flank	NM_145266	NP_660309	Q8WVJ2	NUDC2_HUMAN	NudC domain containing 2	22	CS.					intracellular					0	Renal(175;0.000281)	Medulloblastoma(196;0.0207)|all_neural(177;0.0966)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0981)|OV - Ovarian serous cystadenocarcinoma(192;0.183)|Epithelial(171;0.247)														---	---	---	---
ODZ2	57451	broad.mit.edu	37	5	167645692	167645692	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167645692A>G	uc010jjd.2	+	23	4769	c.4769A>G	c.(4768-4770)GAT>GGT	p.D1590G	ODZ2_uc003lzr.3_Missense_Mutation_p.D1360G|ODZ2_uc003lzt.3_Missense_Mutation_p.D963G|ODZ2_uc010jje.2_Missense_Mutation_p.D854G	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)														---	---	---	---
WWC1	23286	broad.mit.edu	37	5	167850759	167850759	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167850759C>T	uc003lzu.2	+	11	1589	c.1496C>T	c.(1495-1497)ACC>ATC	p.T499I	WWC1_uc003lzv.2_Missense_Mutation_p.T499I|WWC1_uc011den.1_Missense_Mutation_p.T499I|WWC1_uc003lzw.2_Missense_Mutation_p.T298I	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	499					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)														---	---	---	---
SLIT3	6586	broad.mit.edu	37	5	168098380	168098380	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:168098380T>C	uc003mab.2	-	34	4370	c.3950A>G	c.(3949-3951)GAC>GGC	p.D1317G	SLIT3_uc010jjg.2_Missense_Mutation_p.D1324G	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1317	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
SLIT3	6586	broad.mit.edu	37	5	168176497	168176497	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:168176497A>C	uc003mab.2	-	19	2537	c.2117T>G	c.(2116-2118)ATC>AGC	p.I706S	SLIT3_uc010jjg.2_Missense_Mutation_p.I706S	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	706	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
DOCK2	1794	broad.mit.edu	37	5	169145773	169145773	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169145773C>T	uc003maf.2	+	22	2325	c.2245C>T	c.(2245-2247)CGG>TGG	p.R749W	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R241W	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	749					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
DOCK2	1794	broad.mit.edu	37	5	169454930	169454930	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169454930T>C	uc003maf.2	+	34	3525	c.3445T>C	c.(3445-3447)TAC>CAC	p.Y1149H	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.Y641H	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1149	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
GABRP	2568	broad.mit.edu	37	5	170224460	170224460	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170224460T>C	uc003mau.2	+						GABRP_uc011dev.1_Intron	NM_014211	NP_055026			gamma-aminobutyric acid (GABA) A receptor, pi							cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
FBXW11	23291	broad.mit.edu	37	5	171318497	171318497	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171318497T>C	uc003mbm.1	-	6	1134	c.763A>G	c.(763-765)AGT>GGT	p.S255G	FBXW11_uc011dey.1_Missense_Mutation_p.S223G|FBXW11_uc003mbl.1_Missense_Mutation_p.S242G|FBXW11_uc003mbn.1_Missense_Mutation_p.S221G	NM_012300	NP_036432	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11 isoform	255	WD 1.				cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.N260_I262(1)		ovary(1)|breast(1)	2	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
UBTD2	92181	broad.mit.edu	37	5	171638962	171638962	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171638962G>A	uc003mbp.1	-	3	703	c.577C>T	c.(577-579)CGG>TGG	p.R193W		NM_152277	NP_689490	Q8WUN7	UBTD2_HUMAN	dendritic cell-derived ubiquitin-like protein	193	Ubiquitin-like.					cytoplasm					0	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
SH3PXD2B	285590	broad.mit.edu	37	5	171766816	171766816	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171766816C>T	uc003mbr.2	-	13	1464	c.1293G>A	c.(1291-1293)GCG>GCA	p.A431A		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	431					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
DUSP1	1843	broad.mit.edu	37	5	172195808	172195808	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172195808A>G	uc003mbv.1	-	4	1309	c.1061T>C	c.(1060-1062)CTG>CCG	p.L354P	DUSP1_uc011dez.1_Missense_Mutation_p.L212P|DUSP1_uc003mbu.1_Missense_Mutation_p.L242P	NM_004417	NP_004408	P28562	DUS1_HUMAN	dual specificity phosphatase 1	354	Tyrosine-protein phosphatase.				cell cycle|endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding			breast(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00431)|all_lung(126;0.00729)	all_hematologic(541;4.11e-18)|Breast(839;0.00637)|Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.15)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)	GBM - Glioblastoma multiforme(465;0.0103)														---	---	---	---
RPL26L1	51121	broad.mit.edu	37	5	172386967	172386967	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172386967T>C	uc003mcc.2	+	2	133	c.91T>C	c.(91-93)TCA>CCA	p.S31P	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	31					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
BNIP1	662	broad.mit.edu	37	5	172590823	172590823	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172590823C>T	uc003mcj.3	+	6	690	c.586C>T	c.(586-588)CGC>TGC	p.R196C	BNIP1_uc003mci.3_Missense_Mutation_p.R239C|BNIP1_uc003mck.3_Missense_Mutation_p.R205C|BNIP1_uc003mcl.3_Missense_Mutation_p.R162C	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1	196	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)															---	---	---	---
STC2	8614	broad.mit.edu	37	5	172755145	172755145	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:172755145T>C	uc003mco.1	-	1	1362	c.52A>G	c.(52-54)ACC>GCC	p.T18A	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	18					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)															---	---	---	---
C5orf25	375484	broad.mit.edu	37	5	175772238	175772238	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175772238T>C	uc003mds.3	+	12	2816	c.2409T>C	c.(2407-2409)ATT>ATC	p.I803I	C5orf25_uc003mdt.3_Silent_p.I388I|C5orf25_uc003mdr.3_RNA|C5orf25_uc003mdv.2_Silent_p.I264I			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	803											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)														---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	175995828	175995828	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175995828A>G	uc003mem.1	+						CDHR2_uc003men.1_Intron	NM_017675	NP_060145			protocadherin LKC precursor						homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176004743	176004743	+	Missense_Mutation	SNP	G	A	A	rs115283964	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176004743G>A	uc003mem.1	+	14	1522	c.1456G>A	c.(1456-1458)GTC>ATC	p.V486I	CDHR2_uc003men.1_Missense_Mutation_p.V486I	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	486	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176005416	176005416	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176005416A>G	uc003mem.1	+	16	1691	c.1625A>G	c.(1624-1626)AAC>AGC	p.N542S	CDHR2_uc003men.1_Missense_Mutation_p.N542S	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	542	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176011443	176011443	+	Missense_Mutation	SNP	G	A	A	rs116786975	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176011443G>A	uc003mem.1	+	19	2227	c.2161G>A	c.(2161-2163)GCG>ACG	p.A721T	CDHR2_uc003men.1_Missense_Mutation_p.A721T	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	721	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176016062	176016062	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176016062G>A	uc003mem.1	+	22	2953	c.2887G>A	c.(2887-2889)GTC>ATC	p.V963I	CDHR2_uc003men.1_Missense_Mutation_p.V963I	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	963	Extracellular (Potential).|Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
CDHR2	54825	broad.mit.edu	37	5	176017111	176017111	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176017111A>G	uc003mem.1	+	25	3305	c.3239A>G	c.(3238-3240)TAC>TGC	p.Y1080C	CDHR2_uc003men.1_Missense_Mutation_p.Y1080C	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1080	Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2																		---	---	---	---
UNC5A	90249	broad.mit.edu	37	5	176304606	176304606	+	Missense_Mutation	SNP	A	G	G	rs143892682		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176304606A>G	uc003mey.2	+	10	1729	c.1537A>G	c.(1537-1539)ACC>GCC	p.T513A		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	513	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
F12	2161	broad.mit.edu	37	5	176830304	176830304	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176830304G>T	uc003mgo.3	-	12	1531	c.1482C>A	c.(1480-1482)CCC>CCA	p.P494P	PFN3_uc003mgl.2_5'Flank|F12_uc011dfy.1_Missense_Mutation_p.P25H|F12_uc003mgn.3_Missense_Mutation_p.P25H|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	494	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)											Hereditary_Angioedema				---	---	---	---
DDX41	51428	broad.mit.edu	37	5	176939332	176939332	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176939332T>C	uc003mho.2	-	15	1633	c.1612A>G	c.(1612-1614)AAA>GAA	p.K538E	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhk.2_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.K318E|DDX41_uc003mhn.2_Missense_Mutation_p.K407E|DDX41_uc003mhp.2_Missense_Mutation_p.K407E	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	538	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)															---	---	---	---
FAM193B	54540	broad.mit.edu	37	5	176958383	176958383	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176958383C>T	uc003mhs.3	-	7	2665	c.1076G>A	c.(1075-1077)CGA>CAA	p.R359Q	FAM193B_uc003mht.2_Missense_Mutation_p.R18Q|FAM193B_uc003mhu.2_Intron|FAM193B_uc003mhv.2_Missense_Mutation_p.R18Q|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0																		---	---	---	---
N4BP3	23138	broad.mit.edu	37	5	177548744	177548744	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:177548744C>T	uc003mik.1	+	5	1624	c.1377C>T	c.(1375-1377)AGC>AGT	p.S459S	N4BP3_uc003mil.1_Silent_p.S128S	NM_015111	NP_055926	O15049	N4BP3_HUMAN	Nedd4 binding protein 3	459	Potential.					cytoplasmic vesicle membrane					0	all_cancers(89;0.00294)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
CLK4	57396	broad.mit.edu	37	5	178035470	178035470	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178035470A>G	uc003mjf.1	-						CLK4_uc003mjg.1_Intron|CLK4_uc010jku.1_Intron|CLK4_uc003mjh.1_Intron|CLK4_uc010jkv.1_Intron|CLK4_uc011dgg.1_Intron|CLK4_uc011dgh.1_Intron	NM_020666	NP_065717			CDC-like kinase 4							nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)														---	---	---	---
CLK4	57396	broad.mit.edu	37	5	178040801	178040801	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178040801G>A	uc003mjf.1	-	6	694	c.586C>T	c.(586-588)CGT>TGT	p.R196C	CLK4_uc003mjg.1_Missense_Mutation_p.R160C|CLK4_uc010jku.1_Missense_Mutation_p.R16C|CLK4_uc003mjh.1_Missense_Mutation_p.R16C|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Missense_Mutation_p.R196C|CLK4_uc011dgh.1_Missense_Mutation_p.R16C	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	196	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)														---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178413444	178413444	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178413444A>G	uc003mjr.2	-	8	1990	c.1811T>C	c.(1810-1812)GTG>GCG	p.V604A	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Missense_Mutation_p.V187A|GRM6_uc003mjs.1_Missense_Mutation_p.V224A	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	604	Helical; Name=1; (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
ADAMTS2	9509	broad.mit.edu	37	5	178552049	178552049	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178552049G>A	uc003mjw.2	-	19	2883	c.2883C>T	c.(2881-2883)GAC>GAT	p.D961D		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	961	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)														---	---	---	---
ADAMTS2	9509	broad.mit.edu	37	5	178699958	178699958	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178699958C>T	uc003mjw.2	-	3	642	c.642G>A	c.(640-642)CGG>CGA	p.R214R	ADAMTS2_uc011dgm.1_Silent_p.R214R	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	214					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)														---	---	---	---
RUFY1	80230	broad.mit.edu	37	5	179021905	179021905	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179021905C>T	uc003mka.1	+	12	1452	c.1452C>T	c.(1450-1452)ATC>ATT	p.I484I	RUFY1_uc003mkb.1_Silent_p.I376I|RUFY1_uc003mkc.1_Silent_p.I376I|RUFY1_uc003mkd.1_Silent_p.I86I	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	484	Potential.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)												HNSCC(44;0.11)			---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179290695	179290695	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179290695T>C	uc003mlh.2	-	22	3543	c.3506A>G	c.(3505-3507)GAC>GGC	p.D1169G	TBC1D9B_uc003mli.2_Missense_Mutation_p.D1152G|TBC1D9B_uc003mlj.2_Missense_Mutation_p.D1151G|TBC1D9B_uc003mlf.2_Missense_Mutation_p.D243G|TBC1D9B_uc003mlg.2_Missense_Mutation_p.D328G|TBC1D9B_uc011dgv.1_Missense_Mutation_p.D328G	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	1169						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179320379	179320379	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179320379G>A	uc003mlh.2	-	5	703	c.666C>T	c.(664-666)CGC>CGT	p.R222R	TBC1D9B_uc003mli.2_Silent_p.R222R|TBC1D9B_uc003mlj.2_Silent_p.R222R	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	222						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
MAPK9	5601	broad.mit.edu	37	5	179663507	179663507	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179663507G>A	uc003mls.3	-	12	1423	c.1152C>T	c.(1150-1152)AAC>AAT	p.N384N	MAPK9_uc003mlt.3_3'UTR|MAPK9_uc010jlc.2_Silent_p.N384N|MAPK9_uc003mlv.3_3'UTR	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	384					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
CNOT6	57472	broad.mit.edu	37	5	179994949	179994949	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179994949A>G	uc003mlx.2	+	9	1322	c.973A>G	c.(973-975)AAC>GAC	p.N325D	CNOT6_uc010jld.2_Missense_Mutation_p.N325D|CNOT6_uc010jle.2_Missense_Mutation_p.N320D	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	325					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding				0	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)														---	---	---	---
BTNL9	153579	broad.mit.edu	37	5	180477189	180477189	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180477189T>C	uc003mmt.2	+	4	787	c.556T>C	c.(556-558)TGG>CGG	p.W186R	BTNL9_uc011dhi.1_Missense_Mutation_p.W117R	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	186	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
Unknown	0	broad.mit.edu	37	5	180651770	180651770	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180651770G>A	uc003mnb.1	-	2	442	c.122C>T	c.(121-123)GCT>GTT	p.A41V	TRIM41_uc003mnc.1_Silent_p.Q257Q|TRIM41_uc003mnd.1_Silent_p.Q257Q|TRIM41_uc003mne.1_Silent_p.Q257Q|TRIM41_uc003mnf.1_RNA					Homo sapiens cDNA FLJ36305 fis, clone THYMU2004677.																														---	---	---	---
EXOC2	55770	broad.mit.edu	37	6	598135	598135	+	Intron	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:598135G>C	uc003mtd.2	-						EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773			Sec5 protein						exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)														---	---	---	---
TUBB2A	7280	broad.mit.edu	37	6	3154142	3154142	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:3154142G>A	uc003mvc.2	-	4	1379	c.1293C>T	c.(1291-1293)GAC>GAT	p.D431D	TUBB2A_uc003mvb.2_Silent_p.D424D|TUBB2A_uc003mvd.2_Silent_p.D394D	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	tubulin, beta 2	431					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			skin(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.0895)																---	---	---	---
FARS2	10667	broad.mit.edu	37	6	5369143	5369143	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:5369143G>A	uc010jnv.1	+	2	676	c.340G>A	c.(340-342)GAC>AAC	p.D114N	FARS2_uc003mwr.2_Missense_Mutation_p.D114N|FARS2_uc003mws.1_Missense_Mutation_p.D114N	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	114					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)													---	---	---	---
F13A1	2162	broad.mit.edu	37	6	6224953	6224953	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:6224953G>A	uc003mwv.2	-	7	1062	c.939C>T	c.(937-939)GGC>GGT	p.G313G	F13A1_uc011dib.1_Silent_p.G250G	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	313					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)													---	---	---	---
DSP	1832	broad.mit.edu	37	6	7580913	7580913	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7580913G>A	uc003mxp.1	+	23	4769	c.4490G>A	c.(4489-4491)CGG>CAG	p.R1497Q	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1497	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)														---	---	---	---
SNRNP48	154007	broad.mit.edu	37	6	7594321	7594321	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7594321T>C	uc003mxr.2	+						SNRNP48_uc003mxs.2_Intron	NM_152551	NP_689764			U11/U12 snRNP 48K						mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0																		---	---	---	---
TXNDC5	81567	broad.mit.edu	37	6	7904918	7904918	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:7904918T>C	uc003mxv.2	-	2	334	c.302A>G	c.(301-303)GAC>GGC	p.D101G	TXNDC5_uc003mxw.2_Missense_Mutation_p.D58G|TXNDC5_uc010jnz.2_5'UTR|TXNDC5_uc010joa.1_5'UTR	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	101	Thioredoxin 1.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)																	---	---	---	---
MAK	4117	broad.mit.edu	37	6	10764770	10764770	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10764770T>C	uc003mzl.2	-	13	2016	c.1787A>G	c.(1786-1788)AAC>AGC	p.N596S	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.N596S	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	596					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)																---	---	---	---
MAK	4117	broad.mit.edu	37	6	10791920	10791920	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10791920T>A	uc003mzl.2	-	9	1533	c.1304A>T	c.(1303-1305)GAT>GTT	p.D435V	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Missense_Mutation_p.D435V|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	435					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)																---	---	---	---
NEDD9	4739	broad.mit.edu	37	6	11190367	11190367	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:11190367A>G	uc003mzv.2	-	5	1902	c.1735T>C	c.(1735-1737)TAC>CAC	p.Y579H	NEDD9_uc010joz.2_Missense_Mutation_p.Y579H|NEDD9_uc003mzw.3_Missense_Mutation_p.Y433H	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	579					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)															---	---	---	---
HIVEP1	3096	broad.mit.edu	37	6	12131031	12131031	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:12131031C>T	uc003nac.2	+	6	6420	c.6241C>T	c.(6241-6243)CGA>TGA	p.R2081*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	2081					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)																---	---	---	---
GFOD1	54438	broad.mit.edu	37	6	13486930	13486930	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13486930C>T	uc003nat.1	-	1	858	c.193G>A	c.(193-195)GAC>AAC	p.D65N	GFOD1_uc003nas.1_5'Flank|C6orf114_uc003nav.2_5'Flank	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	65						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)															---	---	---	---
SIRT5	23408	broad.mit.edu	37	6	13595769	13595769	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13595769C>A	uc003nay.2	+	6	832	c.536C>A	c.(535-537)CCA>CAA	p.P179Q	SIRT5_uc003naw.2_Missense_Mutation_p.P179Q|SIRT5_uc003nax.2_Missense_Mutation_p.P71Q|SIRT5_uc011dit.1_Missense_Mutation_p.P179Q	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	179	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)													---	---	---	---
MYLIP	29116	broad.mit.edu	37	6	16141988	16141988	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:16141988G>T	uc003nbq.2	+	3	648	c.411G>T	c.(409-411)AAG>AAT	p.K137N	MYLIP_uc003nbr.2_5'UTR	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	137	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)															---	---	---	---
ATXN1	6310	broad.mit.edu	37	6	16326924	16326924	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:16326924T>C	uc003nbt.2	-	8	2589	c.1618A>G	c.(1618-1620)ACC>GCC	p.T540A	ATXN1_uc010jpi.2_Missense_Mutation_p.T540A|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	540	Self-association.|Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)																---	---	---	---
ATXN1	6310	broad.mit.edu	37	6	16326947	16326947	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:16326947T>C	uc003nbt.2	-	8	2566	c.1595A>G	c.(1594-1596)AAC>AGC	p.N532S	ATXN1_uc010jpi.2_Missense_Mutation_p.N532S|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	532	Self-association.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)																---	---	---	---
NUP153	9972	broad.mit.edu	37	6	17628924	17628924	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17628924G>A	uc003ncd.1	-	18	3706	c.3506C>T	c.(3505-3507)GCC>GTC	p.A1169V	NUP153_uc011dje.1_Missense_Mutation_p.A1200V|NUP153_uc010jpl.1_Missense_Mutation_p.A1127V	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	1169					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)															---	---	---	---
NUP153	9972	broad.mit.edu	37	6	17637582	17637582	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17637582G>A	uc003ncd.1	-	16	2466	c.2266C>T	c.(2266-2268)CGA>TGA	p.R756*	NUP153_uc011dje.1_Nonsense_Mutation_p.R787*|NUP153_uc010jpl.1_Nonsense_Mutation_p.R714*	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	756					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)															---	---	---	---
DEK	7913	broad.mit.edu	37	6	18237751	18237751	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18237751T>C	uc003ncr.1	-						DEK_uc011djf.1_Intron|DEK_uc011djg.1_Intron	NM_003472	NP_003463			DEK oncogene isoform 1						chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)					T	NUP214	AML								---	---	---	---
PRL	5617	broad.mit.edu	37	6	22290499	22290499	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:22290499A>G	uc003ndp.2	-	4	915	c.396T>C	c.(394-396)GGT>GGC	p.G132G	PRL_uc003ndo.2_Silent_p.G133G|PRL_uc003ndq.2_Silent_p.G132G	NM_000948	NP_000939	P01236	PRL_HUMAN	prolactin precursor	132					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding				0	Ovarian(93;0.163)																	---	---	---	---
MRS2	57380	broad.mit.edu	37	6	24403466	24403466	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24403466T>C	uc003neb.2	+	1	312	c.190_splice	c.e1+2	p.G64_splice	MRS2_uc003nea.2_Splice_Site_p.G64_splice|MRS2_uc011djl.1_Splice_Site_p.G64_splice|MRS2_uc011djm.1_Splice_Site|MRS2_uc011djn.1_Splice_Site_p.G64_splice	NM_020662	NP_065713			MRS2-like, magnesium homeostasis factor						ion transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
MRS2	57380	broad.mit.edu	37	6	24423918	24423918	+	Missense_Mutation	SNP	G	A	A	rs114959453	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24423918G>A	uc003neb.2	+	11	1450	c.1328G>A	c.(1327-1329)CGT>CAT	p.R443H	MRS2_uc011djl.1_Missense_Mutation_p.R446H|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Missense_Mutation_p.R393H|MRS2_uc003nec.2_Missense_Mutation_p.R320H	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	443	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
TDP2	51567	broad.mit.edu	37	6	24666997	24666997	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24666997A>G	uc003nej.2	-	1	119	c.94T>C	c.(94-96)TTT>CTT	p.F32L	TDP2_uc003nei.2_5'Flank|TDP2_uc010jpu.1_Missense_Mutation_p.F32L|ACOT13_uc010jpv.2_5'Flank|ACOT13_uc003nek.2_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	32					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2													Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
SCGN	10590	broad.mit.edu	37	6	25652698	25652698	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25652698C>T	uc003nfb.2	+	1	270	c.67C>T	c.(67-69)CGC>TGC	p.R23C	SCGN_uc010jpz.2_5'UTR	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	23	EF-hand 1.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
HIST1H2BB	3018	broad.mit.edu	37	6	26043727	26043727	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26043727G>A	uc003nfu.2	-	1	159	c.159C>T	c.(157-159)ACC>ACT	p.T53T	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	53					nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
HIST1H1C	3006	broad.mit.edu	37	6	26056487	26056487	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26056487A>G	uc003nfw.2	-	1	213	c.170T>C	c.(169-171)GTT>GCT	p.V57A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	57	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5																		---	---	---	---
HIST1H2BD	3017	broad.mit.edu	37	6	26158506	26158506	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26158506A>T	uc003ngr.2	+	1	158	c.109A>T	c.(109-111)AGC>TGC	p.S37C	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.S37C	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	37					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2																		---	---	---	---
HIST1H2BH	8345	broad.mit.edu	37	6	26251978	26251978	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26251978C>T	uc003nhh.2	+	1	100	c.100C>T	c.(100-102)CGC>TGC	p.R34C	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	34					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3																		---	---	---	---
BTN2A1	11120	broad.mit.edu	37	6	26463655	26463655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26463655C>T	uc003nib.1	+	4	826	c.614C>T	c.(613-615)ACG>ATG	p.T205M	BTN2A1_uc003nic.1_Missense_Mutation_p.T205M|BTN2A1_uc003nid.1_Missense_Mutation_p.T53M|BTN2A1_uc011dko.1_Missense_Mutation_p.T144M|BTN2A1_uc010jqk.1_5'Flank	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	205	Extracellular (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
HIST1H2AH	85235	broad.mit.edu	37	6	27114940	27114940	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27114940T>C	uc003niz.2	+	1	33	c.33T>C	c.(31-33)GCT>GCC	p.A11A	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	11					nucleosome assembly	nucleosome|nucleus	DNA binding				0																		---	---	---	---
HIST1H4L	8368	broad.mit.edu	37	6	27841075	27841075	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27841075T>C	uc003njz.2	-	1	215	c.214A>G	c.(214-216)ACC>GCC	p.T72A	HIST1H3I_uc003njy.2_5'Flank	NM_003546	NP_003537	P62805	H4_HUMAN	histone cluster 1, H4l	72					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)|breast(1)	2																		---	---	---	---
HIST1H3I	8354	broad.mit.edu	37	6	27841295	27841295	+	5'Flank	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27841295T>C	uc003njy.2	-						HIST1H4L_uc003njz.2_5'Flank	NM_003533	NP_003524			histone cluster 1, H3i						blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1																		---	---	---	---
ZNF165	7718	broad.mit.edu	37	6	28056918	28056918	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28056918A>T	uc003nkg.2	+	5	2212	c.1128A>T	c.(1126-1128)GAA>GAT	p.E376D	ZNF165_uc003nkh.2_Missense_Mutation_p.E376D|ZNF165_uc003nki.3_Missense_Mutation_p.E376D|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	376	C2H2-type 3.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
ZSCAN16	80345	broad.mit.edu	37	6	28093556	28093556	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28093556C>T	uc003nkm.2	+	2	435	c.335C>T	c.(334-336)GCA>GTA	p.A112V	uc010jqw.1_Intron|uc003nkk.1_RNA|uc003nkl.1_Intron|ZSCAN16_uc011dky.1_Missense_Mutation_p.A112V	NM_025231	NP_079507	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	112	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)	1																		---	---	---	---
ZNF193	7746	broad.mit.edu	37	6	28200920	28200920	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28200920C>T	uc003nkq.1	+	4	1264	c.1149C>T	c.(1147-1149)CGC>CGT	p.R383R	ZNF193_uc003nkr.1_Silent_p.R383R|ZNF193_uc010jqz.1_Silent_p.R434R	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	383	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
NKAPL	222698	broad.mit.edu	37	6	28227368	28227368	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28227368G>A	uc003nkt.2	+	1	271	c.219G>A	c.(217-219)GGG>GGA	p.G73G	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	73										upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ZNF323	64288	broad.mit.edu	37	6	28294405	28294405	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28294405T>C	uc003nla.2	-	4	1159	c.759A>G	c.(757-759)GTA>GTG	p.V253V	ZNF323_uc003nld.2_Silent_p.V253V|ZNF323_uc010jra.2_Silent_p.V253V|ZNF323_uc003nlb.2_Silent_p.V94V|ZNF323_uc010jrb.2_Silent_p.V94V|ZNF323_uc003nlc.2_Silent_p.V253V	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	253	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
ZNF311	282890	broad.mit.edu	37	6	28963503	28963503	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28963503G>A	uc003nlu.2	-	7	1789	c.1276C>T	c.(1276-1278)CGG>TGG	p.R426W	ZNF311_uc011dlk.1_Missense_Mutation_p.R334W|ZNF311_uc003nlv.2_Missense_Mutation_p.R334W	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	426	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
OR2B3	442184	broad.mit.edu	37	6	29054534	29054534	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29054534A>G	uc003nlx.2	-	1	557	c.492T>C	c.(490-492)CTT>CTC	p.L164L		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1																		---	---	---	---
OR2J2	26707	broad.mit.edu	37	6	29141711	29141711	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29141711T>C	uc011dlm.1	+	1	401	c.299T>C	c.(298-300)GTT>GCT	p.V100A		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
OR2J2	26707	broad.mit.edu	37	6	29142197	29142197	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29142197A>G	uc011dlm.1	+	1	887	c.785A>G	c.(784-786)CAG>CGG	p.Q262R		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
OR14J1	442191	broad.mit.edu	37	6	29275052	29275052	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29275052G>A	uc011dln.1	+	1	586	c.586G>A	c.(586-588)GCA>ACA	p.A196T		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
OR11A1	26531	broad.mit.edu	37	6	29394640	29394640	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29394640T>C	uc003nmg.2	-	1	870	c.779A>G	c.(778-780)TAT>TGT	p.Y260C		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
HLA-F	3134	broad.mit.edu	37	6	29694737	29694737	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29694737T>A	uc003nno.3	+	7	1238	c.1114T>A	c.(1114-1116)TAT>AAT	p.Y372N	HLA-F_uc011dlx.1_Missense_Mutation_p.Y372N|HLA-F_uc011dly.1_RNA|LOC285830_uc003nnp.2_RNA|LOC285830_uc011dlz.1_RNA	NM_001098479	NP_001091949	P30511	HLAF_HUMAN	major histocompatibility complex, class I, F	Error:Variant_position_missing_in_P30511_after_alignment					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity				0																		---	---	---	---
HLA-G	3135	broad.mit.edu	37	6	29796520	29796520	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29796520G>A	uc003nnw.2	+	4	722	c.544G>A	c.(544-546)GCC>ACC	p.A182T	HLA-G_uc011dmb.1_Missense_Mutation_p.A154T|HLA-G_uc003raj.3_Missense_Mutation_p.A187T|HLA-G_uc003nnz.3_Intron|HLA-G_uc010jrn.2_Intron|HLA-G_uc003nny.3_Intron|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	182	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
TRIM31	11074	broad.mit.edu	37	6	30078246	30078246	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30078246C>T	uc003npg.1	-	4	833	c.723G>A	c.(721-723)ATG>ATA	p.M241I	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	241						mitochondrion	ligase activity|zinc ion binding			lung(1)	1																		---	---	---	---
HLA-L	3139	broad.mit.edu	37	6	30228370	30228370	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30228370C>A	uc003npv.2	+	3	491	c.41C>A	c.(40-42)ACG>AAG	p.T14K		NR_027822				SubName: Full=MHC class I antigen; Flags: Fragment;												0																		---	---	---	---
MDC1	9656	broad.mit.edu	37	6	30673546	30673546	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30673546A>G	uc003nrg.3	-	10	3854	c.3414T>C	c.(3412-3414)ACT>ACC	p.T1138T	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Silent_p.T745T	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1138	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4													Other_conserved_DNA_damage_response_genes					---	---	---	---
IER3	8870	broad.mit.edu	37	6	30712102	30712102	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30712102A>G	uc003nrn.2	-	1	226	c.194T>C	c.(193-195)GTT>GCT	p.V65A	FLOT1_uc003nrm.2_5'Flank|FLOT1_uc011dmr.1_5'Flank	NM_003897	NP_003888	P46695	IEX1_HUMAN	immediate early response 3	65	Cytoplasmic (Potential).				anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding				0																		---	---	---	---
DDR1	780	broad.mit.edu	37	6	30866961	30866961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30866961C>T	uc003nrr.2	+	19	2889	c.2630C>T	c.(2629-2631)CCG>CTG	p.P877L	DDR1_uc010jse.2_Missense_Mutation_p.P840L|DDR1_uc003nrq.2_Missense_Mutation_p.P840L|DDR1_uc003nrs.2_Missense_Mutation_p.P877L|DDR1_uc003nrt.2_Missense_Mutation_p.P840L|DDR1_uc011dms.1_Missense_Mutation_p.P858L|DDR1_uc003nru.2_Missense_Mutation_p.P840L|DDR1_uc003nrv.2_Missense_Mutation_p.P883L|DDR1_uc003nrz.1_Silent_p.P241P	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	877	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)													---	---	---	---
DDR1	780	broad.mit.edu	37	6	30867847	30867847	+	3'UTR	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30867847A>T	uc003nrr.2	+	19					DDR1_uc010jse.2_3'UTR|DDR1_uc003nrq.2_3'UTR|DDR1_uc003nrs.2_3'UTR|DDR1_uc003nrt.2_3'UTR|DDR1_uc011dms.1_3'UTR|DDR1_uc003nru.2_3'UTR|DDR1_uc003nrv.2_3'UTR	NM_013993	NP_054699			discoidin domain receptor family, member 1						cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)													---	---	---	---
VARS2	57176	broad.mit.edu	37	6	30887979	30887979	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30887979G>A	uc003nsc.1	+	12	1911	c.1279G>A	c.(1279-1281)GGG>AGG	p.G427R	VARS2_uc011dmx.1_Missense_Mutation_p.G427R|VARS2_uc011dmy.1_Missense_Mutation_p.G287R|VARS2_uc011dmz.1_Missense_Mutation_p.G457R|VARS2_uc011dna.1_Missense_Mutation_p.G425R|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'UTR|VARS2_uc010jsg.1_5'UTR|VARS2_uc010jsh.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	427					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
CCHCR1	54535	broad.mit.edu	37	6	31113487	31113487	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31113487A>G	uc003nsr.3	-	11	1535	c.1412T>C	c.(1411-1413)GTC>GCC	p.V471A	CCHCR1_uc011dne.1_Missense_Mutation_p.V471A|CCHCR1_uc003nsq.3_Missense_Mutation_p.V524A|CCHCR1_uc003nsp.3_Missense_Mutation_p.V560A|CCHCR1_uc010jsk.1_Missense_Mutation_p.V471A	NM_019052	NP_061925	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1 isoform	471					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			skin(1)	1																		---	---	---	---
BAT2	7916	broad.mit.edu	37	6	31594921	31594921	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31594921A>G	uc003nvb.3	+	11	1485	c.1236A>G	c.(1234-1236)CTA>CTG	p.L412L	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Silent_p.L412L	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	412	4 X 57 AA type A repeats.|2 X type B repeats.|2-1.					cytoplasm|nucleus	protein binding				0																		---	---	---	---
HSPA1L	3305	broad.mit.edu	37	6	31779558	31779558	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31779558A>G	uc003nxh.2	-	2	375	c.192T>C	c.(190-192)AAT>AAC	p.N64N	HSPA1L_uc010jte.2_Silent_p.N64N	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	64					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6																		---	---	---	---
EHMT2	10919	broad.mit.edu	37	6	31851644	31851644	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31851644T>C	uc003nxz.1	-	22	2865	c.2855A>G	c.(2854-2856)TAC>TGC	p.Y952C	EHMT2_uc003nxv.1_5'UTR|EHMT2_uc003nxw.1_5'UTR|EHMT2_uc003nxx.1_Missense_Mutation_p.Y150C|EHMT2_uc003nxy.1_Missense_Mutation_p.Y750C|EHMT2_uc011don.1_Missense_Mutation_p.Y975C|EHMT2_uc003nya.1_Missense_Mutation_p.Y918C	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	952					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TNXB	7148	broad.mit.edu	37	6	32017065	32017065	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32017065A>G	uc003nzl.2	-	28	9935	c.9733T>C	c.(9733-9735)TCC>CCC	p.S3245P	TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3292	Fibronectin type-III 24.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0																		---	---	---	---
TNXB	7148	broad.mit.edu	37	6	32020473	32020473	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32020473C>G	uc003nzl.2	-	26	9285	c.9083G>C	c.(9082-9084)GGC>GCC	p.G3028A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3075	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0																		---	---	---	---
C6orf10	10665	broad.mit.edu	37	6	32304400	32304400	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32304400G>A	uc011dpy.1	-							NM_006781	NP_006772			chromosome 6 open reading frame 10							integral to membrane				skin(1)	1																		---	---	---	---
HLA-DQB1	3119	broad.mit.edu	37	6	32632719	32632719	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32632719A>G	uc003obw.2	-	2	317	c.235T>C	c.(235-237)TAC>CAC	p.Y79H	HLA-DQB1_uc010juc.1_Missense_Mutation_p.Y34H|HLA-DQB1_uc003obv.2_Missense_Mutation_p.Y79H|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.Y79H|HLA-DQB1_uc011dqe.1_Missense_Mutation_p.Y79H	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	79	Extracellular (Potential).|Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)									Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				---	---	---	---
TAP1	6890	broad.mit.edu	37	6	32814837	32814837	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32814837T>C	uc003ocg.2	-						PSMB8_uc003ocf.2_5'Flank|TAP1_uc011dqi.1_Intron	NM_000593	NP_000584			transporter 1, ATP-binding cassette, sub-family						antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1																		---	---	---	---
BRD2	6046	broad.mit.edu	37	6	32944141	32944141	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32944141A>G	uc003ocn.3	+	6	2426	c.725A>G	c.(724-726)CAC>CGC	p.H242R	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.H242R|BRD2_uc003ocp.3_Missense_Mutation_p.H122R|BRD2_uc010juh.2_Missense_Mutation_p.H242R	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	242					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5																		---	---	---	---
RING1	6015	broad.mit.edu	37	6	33177562	33177562	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33177562G>A	uc003odk.2	+	3	432	c.238G>A	c.(238-240)GGG>AGG	p.G80R	RING1_uc011dqx.1_Missense_Mutation_p.G80R|RING1_uc003odl.2_Missense_Mutation_p.G51R	NM_002931	NP_002922	Q06587	RING1_HUMAN	ring finger protein 1	80	Necessary for transcriptional repression (By similarity).|RING-type.				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear speck|PcG protein complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
TAPBP	6892	broad.mit.edu	37	6	33281604	33281604	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33281604G>A	uc003odx.1	-	2	246	c.75C>T	c.(73-75)ATC>ATT	p.I25I	TAPBP_uc010jus.1_Silent_p.I25I|TAPBP_uc003ody.2_Silent_p.I25I|TAPBP_uc003odz.2_Silent_p.I25I|TAPBP_uc010jut.1_Silent_p.I25I|TAPBP_uc011drc.1_Silent_p.I25I	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	25	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1																		---	---	---	---
SYNGAP1	8831	broad.mit.edu	37	6	33411288	33411288	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33411288G>A	uc011dri.1	+	15	3154	c.2959G>A	c.(2959-2961)GAC>AAC	p.D987N	SYNGAP1_uc010juy.2_Missense_Mutation_p.D958N|SYNGAP1_uc010juz.2_Missense_Mutation_p.D699N	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	987					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4																		---	---	---	---
SNRPC	6631	broad.mit.edu	37	6	34730484	34730484	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34730484T>C	uc003ojt.1	+							NM_003093	NP_003084			small nuclear ribonucleoprotein polypeptide C						spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			pancreas(1)	1																		---	---	---	---
ANKS1A	23294	broad.mit.edu	37	6	34937796	34937796	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34937796C>T	uc003ojx.3	+	3	430	c.288C>T	c.(286-288)GTC>GTT	p.V96V	ANKS1A_uc011dss.1_Silent_p.V96V|ANKS1A_uc011dst.1_5'UTR|ANKS1A_uc010jvp.1_5'UTR|ANKS1A_uc010jvq.1_RNA|ANKS1A_uc010jvr.1_5'Flank	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	96	ANK 1.					cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
SRPK1	6732	broad.mit.edu	37	6	35854499	35854499	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35854499A>G	uc003olj.2	-	6	601	c.478_splice	c.e6+1	p.H160_splice	SRPK1_uc011dtg.1_Splice_Site_p.H144_splice|SRPK1_uc003olh.2_Splice_Site_p.H53_splice|SRPK1_uc003oli.2_Splice_Site_p.H53_splice	NM_003137	NP_003128			SFRS protein kinase 1						cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1																		---	---	---	---
SLC26A8	116369	broad.mit.edu	37	6	35919034	35919034	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35919034A>T	uc003olm.2	-	19	2489	c.2378T>A	c.(2377-2379)CTG>CAG	p.L793Q	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.L375Q|SLC26A8_uc003oln.2_Missense_Mutation_p.L793Q|SLC26A8_uc003oll.2_Missense_Mutation_p.L688Q	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	793	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2																		---	---	---	---
SLC26A8	116369	broad.mit.edu	37	6	35930388	35930388	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35930388G>A	uc003olm.2	-	12	1487	c.1376C>T	c.(1375-1377)GCT>GTT	p.A459V	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.A41V|SLC26A8_uc003oln.2_Missense_Mutation_p.A459V|SLC26A8_uc003oll.2_Missense_Mutation_p.A354V	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	459	Helical; (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2																		---	---	---	---
PNPLA1	285848	broad.mit.edu	37	6	36274133	36274133	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36274133C>T	uc010jwf.2	+	7	1449	c.1449C>T	c.(1447-1449)ACC>ACT	p.T483T	PNPLA1_uc003olw.1_Silent_p.T388T|PNPLA1_uc010jwe.1_Silent_p.T397T	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	483					lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4																		---	---	---	---
FGD2	221472	broad.mit.edu	37	6	36993651	36993651	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36993651C>T	uc010jwp.1	+	14	1713	c.1542C>T	c.(1540-1542)TAC>TAT	p.Y514Y	FGD2_uc003ong.2_Silent_p.Y236Y|FGD2_uc011dtv.1_Silent_p.Y142Y|FGD2_uc003onj.1_Silent_p.Y91Y	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	514	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3																		---	---	---	---
TBC1D22B	55633	broad.mit.edu	37	6	37298880	37298880	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37298880C>T	uc003onn.2	+	13	1596	c.1450C>T	c.(1450-1452)CTG>TTG	p.L484L	TBC1D22B_uc010jwt.2_RNA|TBC1D22B_uc003onp.2_Silent_p.L142L	NM_017772	NP_060242	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	484						intracellular	Rab GTPase activator activity				0			OV - Ovarian serous cystadenocarcinoma(102;0.241)															---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38723785	38723785	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38723785C>T	uc003ooe.1	+	8	1394	c.794C>T	c.(793-795)GCC>GTC	p.A265V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38843564	38843564	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38843564C>A	uc003ooe.1	+	51	7767	c.7167C>A	c.(7165-7167)GGC>GGA	p.G2389G		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38919215	38919215	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38919215C>T	uc003ooe.1	+	80	12319	c.11719C>T	c.(11719-11721)CGG>TGG	p.R3907W	DNAH8_uc003oog.1_Missense_Mutation_p.R356W|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38998045	38998045	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38998045T>C	uc003ooe.1	+	91	13950	c.13350T>C	c.(13348-13350)TGT>TGC	p.C4450C		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
KCNK17	89822	broad.mit.edu	37	6	39267322	39267322	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39267322G>A	uc003ooo.2	-	5	1020	c.880C>T	c.(880-882)CCT>TCT	p.P294S	KCNK17_uc003oop.2_3'UTR	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	294	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2																		---	---	---	---
MED20	9477	broad.mit.edu	37	6	41875024	41875024	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41875024A>G	uc003ork.2	-	4	546	c.425T>C	c.(424-426)GTG>GCG	p.V142A	MED20_uc003orj.2_Missense_Mutation_p.V77A|MED20_uc011duh.1_Missense_Mutation_p.W117R|MED20_uc011dui.1_RNA|MED20_uc011duj.1_Missense_Mutation_p.V77A	NM_004275	NP_004266	Q9H944	MED20_HUMAN	Trf (TATA binding protein-related	142					regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|protein binding				0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000367)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42620271	42620271	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42620271C>G	uc011dur.1	+	25	2657	c.2657C>G	c.(2656-2658)GCA>GGA	p.A886G	UBR2_uc011dus.1_Missense_Mutation_p.A531G|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	886					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42650804	42650804	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42650804A>G	uc011dur.1	+	43	4730	c.4730A>G	c.(4729-4731)AAC>AGC	p.N1577S	UBR2_uc011dus.1_Missense_Mutation_p.N1222S|UBR2_uc003osh.2_RNA|UBR2_uc011dut.1_Missense_Mutation_p.N165S	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1577					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
CUL7	9820	broad.mit.edu	37	6	43012495	43012495	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43012495G>A	uc003otq.2	-	16	3470	c.3167C>T	c.(3166-3168)TCC>TTC	p.S1056F	CUL7_uc010jyg.2_Missense_Mutation_p.S335F|CUL7_uc011dvb.1_Missense_Mutation_p.S1140F|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1056					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)															---	---	---	---
MRPL2	51069	broad.mit.edu	37	6	43023745	43023745	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43023745A>G	uc003ots.1	-	5	644	c.521T>C	c.(520-522)GTT>GCT	p.V174A	CUL7_uc011dvb.1_5'Flank|CUL7_uc003otq.2_5'Flank|CUL7_uc010jyh.2_5'Flank|KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_Silent_p.S198S	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor	174					translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)														---	---	---	---
MRPL2	51069	broad.mit.edu	37	6	43025842	43025842	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43025842G>A	uc003ots.1	-	2	349	c.226C>T	c.(226-228)CCA>TCA	p.P76S	KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.1_Missense_Mutation_p.P76S|MRPL2_uc010jyi.2_3'UTR|MRPL2_uc003ott.3_Missense_Mutation_p.P76S|KLC4_uc011dvd.1_5'Flank|KLC4_uc003otu.2_5'Flank|KLC4_uc003otv.1_5'Flank|KLC4_uc003otw.1_5'Flank|KLC4_uc003otx.1_5'Flank|KLC4_uc003oty.1_5'Flank|KLC4_uc003otz.1_5'Flank	NM_015950	NP_057034	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2 precursor	76					translation	mitochondrion|ribosome	structural constituent of ribosome				0		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)														---	---	---	---
TTBK1	84630	broad.mit.edu	37	6	43226884	43226884	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43226884C>T	uc003ouq.1	+	11	1404	c.1125C>T	c.(1123-1125)CCC>CCT	p.P375P		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	375						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)															---	---	---	---
ZNF318	24149	broad.mit.edu	37	6	43308192	43308192	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43308192G>A	uc003oux.2	-	10	3622	c.3544C>T	c.(3544-3546)CGC>TGC	p.R1182C	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1182					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)															---	---	---	---
ABCC10	89845	broad.mit.edu	37	6	43410857	43410857	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:43410857C>T	uc003ouy.1	+	10	2591	c.2376C>T	c.(2374-2376)GAC>GAT	p.D792D	ABCC10_uc003ouz.1_Silent_p.D764D|ABCC10_uc010jyo.1_Translation_Start_Site	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	792	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)															---	---	---	---
TMEM63B	55362	broad.mit.edu	37	6	44116270	44116270	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44116270T>C	uc003owr.2	+	14	1206	c.1142T>C	c.(1141-1143)GTG>GCG	p.V381A	TMEM63B_uc003owq.1_Missense_Mutation_p.V381A|TMEM63B_uc003ows.2_Missense_Mutation_p.V284A|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	381						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)															---	---	---	---
TCTE1	202500	broad.mit.edu	37	6	44250298	44250298	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44250298T>C	uc003oxi.2	-	4	1003	c.847_splice	c.e4-1	p.I283_splice	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345			t-complex-associated testis expressed 1											ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
TCTE1	202500	broad.mit.edu	37	6	44253990	44253990	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:44253990T>A	uc003oxi.2	-	3	713	c.557A>T	c.(556-558)AAT>ATT	p.N186I	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	186										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)															---	---	---	---
GPR116	221395	broad.mit.edu	37	6	46826170	46826170	+	Missense_Mutation	SNP	G	A	A	rs141322343	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46826170G>A	uc003oyo.3	-	17	3759	c.3470C>T	c.(3469-3471)ACG>ATG	p.T1157M	GPR116_uc011dwj.1_Missense_Mutation_p.T712M|GPR116_uc011dwk.1_Missense_Mutation_p.T586M|GPR116_uc003oyp.3_Missense_Mutation_p.T1015M|GPR116_uc003oyq.3_Missense_Mutation_p.T1157M|GPR116_uc010jzi.1_Missense_Mutation_p.T829M	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	1157	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)															---	---	---	---
GPR115	221393	broad.mit.edu	37	6	47682298	47682298	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47682298T>C	uc003oza.1	+	6	1575	c.1317T>C	c.(1315-1317)CGT>CGC	p.R439R	GPR115_uc003oyz.1_Silent_p.R496R|GPR115_uc003ozb.1_Silent_p.R437R	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	439	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8																		---	---	---	---
RHAG	6005	broad.mit.edu	37	6	49574880	49574880	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49574880A>G	uc003ozk.3	-	8	1183	c.1121T>C	c.(1120-1122)GTT>GCT	p.V374A	RHAG_uc010jzl.2_Missense_Mutation_p.V374A|RHAG_uc010jzm.2_Silent_p.C333C	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	374	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)																	---	---	---	---
PGK2	5232	broad.mit.edu	37	6	49753787	49753787	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49753787C>T	uc003ozu.2	-	1	1221	c.1114G>A	c.(1114-1116)GGG>AGG	p.G372R		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	372					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)																	---	---	---	---
TFAP2D	83741	broad.mit.edu	37	6	50681777	50681777	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50681777T>C	uc003paf.2	+	1	521	c.9T>C	c.(7-9)ACT>ACC	p.T3T	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	3							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)																	---	---	---	---
C6orf142	90523	broad.mit.edu	37	6	54025582	54025582	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54025582T>C	uc003pcg.3	+	7	992	c.879T>C	c.(877-879)GGT>GGC	p.G293G	C6orf142_uc003pcf.2_Silent_p.G817G|C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Silent_p.G828G	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	293						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)																	---	---	---	---
FAM83B	222584	broad.mit.edu	37	6	54805207	54805207	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54805207C>T	uc003pck.2	+	5	1554	c.1438C>T	c.(1438-1440)CGA>TGA	p.R480*		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	480										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)																	---	---	---	---
FAM83B	222584	broad.mit.edu	37	6	54806569	54806569	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54806569T>C	uc003pck.2	+	5	2916	c.2800T>C	c.(2800-2802)TAC>CAC	p.Y934H		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	934										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)																	---	---	---	---
GFRAL	389400	broad.mit.edu	37	6	55264054	55264054	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55264054A>T	uc003pcm.1	+	7	1115	c.1029A>T	c.(1027-1029)GGA>GGT	p.G343G		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	343	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)															---	---	---	---
HMGCLL1	54511	broad.mit.edu	37	6	55441964	55441964	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55441964G>A	uc003pcn.2	-	2	269	c.110C>T	c.(109-111)ACT>ATT	p.T37I	HMGCLL1_uc003pco.2_Intron|HMGCLL1_uc010jzx.2_Intron|HMGCLL1_uc011dxc.1_Intron|HMGCLL1_uc011dxd.1_Intron|HMGCLL1_uc011dxe.1_Intron|HMGCLL1_uc003pcp.2_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	37							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)															---	---	---	---
BMP5	653	broad.mit.edu	37	6	55684535	55684535	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:55684535A>G	uc003pcq.2	-	2	1313	c.601T>C	c.(601-603)TAC>CAC	p.Y201H	BMP5_uc011dxf.1_Missense_Mutation_p.Y201H	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	201					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
DST	667	broad.mit.edu	37	6	56330869	56330869	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56330869T>C	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pcv.3_5'Flank|DST_uc003pcw.3_Intron|DST_uc003pcx.3_Intron	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
DST	667	broad.mit.edu	37	6	56468029	56468029	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56468029T>A	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
PRIM2	5558	broad.mit.edu	37	6	57512649	57512649	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57512649T>C	uc003pdx.2	+	15	1564	c.1477T>C	c.(1477-1479)TCT>CCT	p.S493P		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	493					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)														---	---	---	---
KHDRBS2	202559	broad.mit.edu	37	6	62688109	62688109	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:62688109T>C	uc003peg.2	-	4	592	c.345A>G	c.(343-345)GAA>GAG	p.E115E		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	115	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)														---	---	---	---
PHF3	23469	broad.mit.edu	37	6	64408425	64408425	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:64408425G>A	uc003pep.1	+	7	2938	c.2912G>A	c.(2911-2913)CGG>CAG	p.R971Q	PHF3_uc010kah.1_Missense_Mutation_p.R785Q|PHF3_uc003pen.2_Missense_Mutation_p.R883Q|PHF3_uc011dxs.1_Missense_Mutation_p.R240Q	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	971	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)															---	---	---	---
LMBRD1	55788	broad.mit.edu	37	6	70490403	70490403	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70490403A>G	uc003pfa.2	-	3	405	c.290T>C	c.(289-291)GTA>GCA	p.V97A	LMBRD1_uc003pez.2_Missense_Mutation_p.V24A|LMBRD1_uc010kal.2_Missense_Mutation_p.V24A|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	97	Extracellular (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1																		---	---	---	---
COL19A1	1310	broad.mit.edu	37	6	70831829	70831829	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70831829A>G	uc003pfc.1	+	17	1453	c.1336A>G	c.(1336-1338)AAC>GAC	p.N446D	COL19A1_uc010kam.1_Missense_Mutation_p.N342D	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	446					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4																		---	---	---	---
COL19A1	1310	broad.mit.edu	37	6	70909413	70909413	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70909413G>A	uc003pfc.1	+	49	3313	c.3196G>A	c.(3196-3198)GGG>AGG	p.G1066R		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1066	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4																		---	---	---	---
RIMS1	22999	broad.mit.edu	37	6	72806716	72806716	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72806716C>T	uc003pga.2	+	3	387	c.310C>T	c.(310-312)CGT>TGT	p.R104C		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	104	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)																---	---	---	---
EEF1A1	1915	broad.mit.edu	37	6	74227952	74227952	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74227952G>A	uc003phi.2	-	6	1102	c.1065C>T	c.(1063-1065)GCC>GCT	p.A355A	EEF1A1_uc003phd.2_Silent_p.A80A|EEF1A1_uc003phe.2_Silent_p.A345A|EEF1A1_uc003phf.2_Silent_p.A348A|EEF1A1_uc003phg.2_Intron|EEF1A1_uc003phh.2_Silent_p.A201A|EEF1A1_uc003phj.2_Silent_p.A355A|EEF1A1_uc003phk.2_Silent_p.A355A|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	355						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0																		---	---	---	---
SLC17A5	26503	broad.mit.edu	37	6	74348179	74348179	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74348179G>A	uc003phn.3	-	4	697	c.569C>T	c.(568-570)GCT>GTT	p.A190V	SLC17A5_uc010kax.2_5'Flank|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Intron	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	190					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6																		---	---	---	---
CD109	135228	broad.mit.edu	37	6	74512960	74512960	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74512960C>T	uc003php.2	+	24	3321	c.2896C>T	c.(2896-2898)CTC>TTC	p.L966F	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Missense_Mutation_p.L966F|CD109_uc010kba.2_Missense_Mutation_p.L889F	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	966						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4																		---	---	---	---
CD109	135228	broad.mit.edu	37	6	74516797	74516797	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74516797T>C	uc003php.2	+	25	3614	c.3189_splice	c.e25+2	p.Q1063_splice	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Splice_Site_p.Q1063_splice|CD109_uc010kba.2_Splice_Site_p.Q986_splice	NM_133493	NP_598000			CD109 antigen isoform 1 precursor							anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4																		---	---	---	---
CD109	135228	broad.mit.edu	37	6	74528108	74528108	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:74528108T>C	uc003php.2	+						CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Intron|CD109_uc010kba.2_Intron	NM_133493	NP_598000			CD109 antigen isoform 1 precursor							anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75848672	75848672	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75848672C>T	uc003phs.2	-	28	5129	c.4963G>A	c.(4963-4965)GTG>ATG	p.V1655M	COL12A1_uc003pht.2_Missense_Mutation_p.V491M	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1655	Fibronectin type-III 12.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75875301	75875301	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75875301T>C	uc003phs.2	-	14	3071	c.2905A>G	c.(2905-2907)ACC>GCC	p.T969A	COL12A1_uc003pht.2_Intron	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	969	Fibronectin type-III 6.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
SENP6	26054	broad.mit.edu	37	6	76369129	76369129	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76369129T>C	uc003pid.3	+						SENP6_uc003pie.3_Intron|SENP6_uc003pic.2_Intron|SENP6_uc003pif.1_Intron	NM_015571	NP_056386			SUMO1/sentrin specific peptidase 6 isoform 1						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)																---	---	---	---
IRAK1BP1	134728	broad.mit.edu	37	6	79577355	79577355	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79577355G>A	uc003pim.2	+	1	167	c.62G>A	c.(61-63)CGG>CAG	p.R21Q	IRAK1BP1_uc010kbg.1_RNA	NM_001010844	NP_001010844	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1	21	Intrinsically disordered.				I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79724917	79724917	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79724917A>G	uc003pir.2	-	15	1632	c.1406T>C	c.(1405-1407)GTA>GCA	p.V469A	PHIP_uc011dyp.1_Missense_Mutation_p.V469A	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	469	WD 7.		V -> I (in a colorectal cancer sample; somatic mutation).		insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding	p.V469I(1)		large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
TTK	7272	broad.mit.edu	37	6	80749999	80749999	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80749999T>C	uc003pjc.2	+	20	2466	c.2392_splice	c.e20+2	p.V798_splice	TTK_uc003pjb.3_Splice_Site_p.V797_splice	NM_003318	NP_003309			TTK protein kinase						mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)														---	---	---	---
IBTK	25998	broad.mit.edu	37	6	82950212	82950212	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82950212T>C	uc003pjl.1	-	2					IBTK_uc011dyv.1_5'UTR|IBTK_uc011dyw.1_5'UTR|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_5'UTR	NM_015525	NP_056340			inhibitor of Bruton's tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)														---	---	---	---
DOPEY1	23033	broad.mit.edu	37	6	83819867	83819867	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83819867T>C	uc003pjs.1	+	6	775	c.515T>C	c.(514-516)GTT>GCT	p.V172A	DOPEY1_uc011dyy.1_Missense_Mutation_p.V172A|DOPEY1_uc010kbl.1_Missense_Mutation_p.V172A	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	172					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)														---	---	---	---
PGM3	5238	broad.mit.edu	37	6	83891476	83891476	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83891476T>C	uc003pjv.2	-	6	806	c.766A>G	c.(766-768)AGT>GGT	p.S256G	PGM3_uc003pjw.2_Missense_Mutation_p.S175G|PGM3_uc011dyz.1_Missense_Mutation_p.S284G	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	256					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)														---	---	---	---
ME1	4199	broad.mit.edu	37	6	83933648	83933648	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83933648C>T	uc003pjy.2	-	12	1386	c.1280G>A	c.(1279-1281)CGT>CAT	p.R427H	ME1_uc011dzb.1_Missense_Mutation_p.R352H|ME1_uc011dzc.1_Missense_Mutation_p.R261H	NM_002395	NP_002386	P48163	MAOX_HUMAN	cytosolic malic enzyme 1	427					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)													---	---	---	---
PRSS35	167681	broad.mit.edu	37	6	84234379	84234379	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84234379G>A	uc003pjz.2	+	2	1382	c.1219G>A	c.(1219-1221)GAT>AAT	p.D407N	PRSS35_uc010kbm.2_Missense_Mutation_p.D407N	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	407	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)														---	---	---	---
SNX14	57231	broad.mit.edu	37	6	86281916	86281916	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86281916T>C	uc003pkr.2	-	4	549	c.356A>G	c.(355-357)GAA>GGA	p.E119G	SNX14_uc003pkq.2_5'UTR|SNX14_uc011dzg.1_Missense_Mutation_p.E67G|SNX14_uc003pks.2_Missense_Mutation_p.E119G|SNX14_uc003pkt.2_Missense_Mutation_p.E119G	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	119					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)														---	---	---	---
ZNF292	23036	broad.mit.edu	37	6	87969203	87969203	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87969203T>A	uc003plm.3	+	8	5897	c.5856T>A	c.(5854-5856)CCT>CCA	p.P1952P		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1952	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)														---	---	---	---
SLC35A1	10559	broad.mit.edu	37	6	88210879	88210879	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88210879A>G	uc011dzj.1	+	4	437	c.358A>G	c.(358-360)ACC>GCC	p.T120A	SLC35A1_uc003plx.2_RNA|SLC35A1_uc010kbw.2_5'UTR|SLC35A1_uc003plz.2_RNA|SLC35A1_uc011dzi.1_5'UTR|SLC35A1_uc003ply.2_RNA|SLC35A1_uc010kbx.2_Missense_Mutation_p.T120A|SLC35A1_uc010kby.2_RNA	NM_006416	NP_006407	P78382	S35A1_HUMAN	solute carrier family 35 (CMP-sialic acid	120	Helical; (Potential).				carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
CNR1	1268	broad.mit.edu	37	6	88853864	88853864	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88853864G>A	uc011dzq.1	-	2	4693	c.1130C>T	c.(1129-1131)ACG>ATG	p.T377M	CNR1_uc010kbz.2_Missense_Mutation_p.T377M|CNR1_uc011dzr.1_Missense_Mutation_p.T377M|CNR1_uc011dzs.1_Missense_Mutation_p.T377M|CNR1_uc003pmq.3_Missense_Mutation_p.T377M|CNR1_uc011dzt.1_Missense_Mutation_p.T377M|CNR1_uc010kca.2_Missense_Mutation_p.T344M	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	377	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)													---	---	---	---
PNRC1	10957	broad.mit.edu	37	6	89790771	89790771	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89790771C>A	uc003pmv.2	+	1	343	c.158C>A	c.(157-159)CCG>CAG	p.P53Q	PNRC1_uc003pmu.2_Missense_Mutation_p.P53Q|PNRC1_uc003pmx.2_5'Flank	NM_006813	NP_006804	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	53					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)											Multiple Myeloma(7;0.094)			---	---	---	---
MDN1	23195	broad.mit.edu	37	6	90397786	90397786	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90397786T>C	uc003pnn.1	-							NM_014611	NP_055426			MDN1, midasin homolog						protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)														---	---	---	---
BACH2	60468	broad.mit.edu	37	6	90661192	90661192	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90661192G>A	uc011eab.1	-	7	1442	c.633C>T	c.(631-633)GAC>GAT	p.D211D	BACH2_uc003pnw.2_Silent_p.D211D|BACH2_uc010kch.2_Silent_p.D211D	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	211						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)														---	---	---	---
BACH2	60468	broad.mit.edu	37	6	90661316	90661316	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:90661316G>A	uc011eab.1	-	7	1318	c.509C>T	c.(508-510)ACG>ATG	p.T170M	BACH2_uc003pnw.2_Missense_Mutation_p.T170M|BACH2_uc010kch.2_Missense_Mutation_p.T170M	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	170						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)														---	---	---	---
KIAA0776	23376	broad.mit.edu	37	6	96974251	96974251	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:96974251T>C	uc003por.2	+	5	453	c.405T>C	c.(403-405)GGT>GGC	p.G135G	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	135	Required for E3 UFM1-protein ligase activity.|Involved in CDK5RAP3-binding.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)														---	---	---	---
KLHL32	114792	broad.mit.edu	37	6	97562108	97562108	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97562108T>C	uc010kcm.1	+	7	1549	c.1077T>C	c.(1075-1077)AGT>AGC	p.S359S	KLHL32_uc003poy.2_Silent_p.S359S|KLHL32_uc011ead.1_Silent_p.S323S|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.S290S|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	359	Kelch 2.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97679388	97679388	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97679388A>T	uc003ppb.2	-	13	1709	c.1443T>A	c.(1441-1443)TAT>TAA	p.Y481*	C6orf167_uc011eaf.1_Nonsense_Mutation_p.Y441*|C6orf167_uc010kcn.1_Nonsense_Mutation_p.Y255*	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	481					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97715821	97715821	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97715821A>T	uc003ppb.2	-	8	1021	c.755T>A	c.(754-756)ATC>AAC	p.I252N	C6orf167_uc011eaf.1_Missense_Mutation_p.I252N|C6orf167_uc010kcn.1_Missense_Mutation_p.I26N|C6orf167_uc010kco.1_Missense_Mutation_p.I26N|C6orf167_uc003ppc.2_Missense_Mutation_p.I252N	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	252					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
FBXL4	26235	broad.mit.edu	37	6	99328484	99328484	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99328484C>T	uc003ppf.1	-	7	1692	c.1334G>A	c.(1333-1335)AGC>AAC	p.S445N	FBXL4_uc003ppg.1_Missense_Mutation_p.S445N|FBXL4_uc003pph.1_Missense_Mutation_p.S47N|FBXL4_uc010kcp.2_Intron	NM_012160	NP_036292	Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	445	LRR 3.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				skin(2)	2		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)														---	---	---	---
COQ3	51805	broad.mit.edu	37	6	99828203	99828203	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99828203C>T	uc003ppk.2	-	3	275	c.248G>A	c.(247-249)AGA>AAA	p.R83K		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	83					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)														---	---	---	---
SFRS18	25957	broad.mit.edu	37	6	99860536	99860536	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99860536T>C	uc003ppo.3	-	4	396	c.168A>G	c.(166-168)CAA>CAG	p.Q56Q	SFRS18_uc003ppp.3_Silent_p.Q56Q|SFRS18_uc011eag.1_Silent_p.Q56Q|SFRS18_uc003ppr.2_Silent_p.Q56Q|SFRS18_uc003ppt.2_Silent_p.Q56Q|SFRS18_uc003pps.2_Silent_p.Q56Q	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	56	Gln-rich.					nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)														---	---	---	---
PRDM13	59336	broad.mit.edu	37	6	100062346	100062346	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:100062346A>G	uc003pqg.1	+	4	2096	c.1835A>G	c.(1834-1836)GAC>GGC	p.D612G		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	612	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)														---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101054919	101054919	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101054919T>C	uc003pqk.2	-	31	5160	c.4831A>G	c.(4831-4833)ACC>GCC	p.T1611A		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1611	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
ASCC3	10973	broad.mit.edu	37	6	101296426	101296426	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:101296426A>G	uc003pqk.2	-	4	728	c.399T>C	c.(397-399)GCT>GCC	p.A133A	ASCC3_uc011eai.1_Silent_p.A35A|ASCC3_uc003pql.2_Silent_p.A133A|ASCC3_uc010kcv.2_Silent_p.A133A	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)														---	---	---	---
GRIK2	2898	broad.mit.edu	37	6	102337511	102337511	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:102337511A>G	uc003pqp.3	+						GRIK2_uc003pqn.2_Intron|GRIK2_uc003pqo.3_Intron|GRIK2_uc010kcw.2_Intron	NM_021956	NP_068775			glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)													---	---	---	---
PREP	5550	broad.mit.edu	37	6	105781311	105781311	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105781311G>A	uc003prc.2	-	8	1096	c.893C>T	c.(892-894)ACG>ATG	p.T298M		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	298				T -> A (in Ref. 2; BAA04661).	proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)													---	---	---	---
RTN4IP1	84816	broad.mit.edu	37	6	107050772	107050772	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107050772C>T	uc003prj.2	-	5	1123	c.646G>A	c.(646-648)GGA>AGA	p.G216R	RTN4IP1_uc010kdd.2_Intron|RTN4IP1_uc003prk.2_Missense_Mutation_p.G116R	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	216						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)														---	---	---	---
BEND3	57673	broad.mit.edu	37	6	107391162	107391162	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107391162G>A	uc003prs.2	-	5	1883	c.1233C>T	c.(1231-1233)GCC>GCT	p.A411A		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	411	BEN 2.									ovary(3)	3																		---	---	---	---
PDSS2	57107	broad.mit.edu	37	6	107780386	107780386	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107780386A>G	uc003prt.2	-	1	394	c.104T>C	c.(103-105)GTG>GCG	p.V35A	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Missense_Mutation_p.V35A|PDSS2_uc003pru.2_Missense_Mutation_p.V35A|PDSS2_uc003prv.2_Missense_Mutation_p.V35A	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	35					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)												OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
OSTM1	28962	broad.mit.edu	37	6	108385478	108385478	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108385478G>A	uc003psd.2	-	2	514	c.428C>T	c.(427-429)GCC>GTC	p.A143V		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	143	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)												OREG0003974	type=REGULATORY REGION|Gene=OSTM1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
SESN1	27244	broad.mit.edu	37	6	109323528	109323528	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109323528G>A	uc003pst.3	-	2	213	c.121C>T	c.(121-123)CCT>TCT	p.P41S	SESN1_uc003psu.2_Missense_Mutation_p.P100S	NM_014454	NP_055269	Q9Y6P5	SESN1_HUMAN	sestrin 1	41					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)														---	---	---	---
MICAL1	64780	broad.mit.edu	37	6	109774467	109774467	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109774467C>A	uc003ptj.2	-	3	824	c.570G>T	c.(568-570)AAG>AAT	p.K190N	MICAL1_uc003ptk.2_Missense_Mutation_p.K190N|MICAL1_uc010kdr.2_Missense_Mutation_p.K190N|MICAL1_uc011eaq.1_Missense_Mutation_p.K209N	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	190					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)														---	---	---	---
ZBTB24	9841	broad.mit.edu	37	6	109787303	109787303	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109787303T>C	uc003ptl.1	-	7	2013	c.1845A>G	c.(1843-1845)GAA>GAG	p.E615E	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Silent_p.E559E|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)														---	---	---	---
AKD1	221264	broad.mit.edu	37	6	109962765	109962765	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109962765T>C	uc003ptn.2	-	10	966	c.889A>G	c.(889-891)AAA>GAA	p.K297E	AKD1_uc003ptr.3_Missense_Mutation_p.K297E	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	297					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1																		---	---	---	---
GPR6	2830	broad.mit.edu	37	6	110300895	110300895	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110300895A>T	uc011eaw.1	+	2	760	c.580A>T	c.(580-582)ACC>TCC	p.T194S	GPR6_uc011eav.1_Missense_Mutation_p.T209S|GPR6_uc003ptu.2_Missense_Mutation_p.T194S	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	194	Helical; Name=4; (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)														---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110434550	110434550	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110434550G>A	uc003ptv.1	-	5	1084	c.247C>T	c.(247-249)CTT>TTT	p.L83F	WASF1_uc003ptw.1_Missense_Mutation_p.L83F|WASF1_uc003ptx.1_Missense_Mutation_p.L83F|WASF1_uc003pty.1_Missense_Mutation_p.L83F|WASF1_uc003ptz.1_Missense_Mutation_p.L83F	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	83					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
DDO	8528	broad.mit.edu	37	6	110714482	110714482	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110714482C>T	uc003puc.2	-	5	610	c.606G>A	c.(604-606)CCG>CCA	p.P202P	C6orf186_uc003pub.2_Intron|DDO_uc003pud.2_Silent_p.P143P	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	174					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)														---	---	---	---
CDK19	23097	broad.mit.edu	37	6	110943323	110943323	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110943323T>C	uc003puh.1	-	11	1151	c.1078A>G	c.(1078-1080)AAT>GAT	p.N360D	CDK19_uc003pui.1_Missense_Mutation_p.N300D|CDK19_uc011eax.1_Missense_Mutation_p.N236D	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	360							ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
SLC16A10	117247	broad.mit.edu	37	6	111543440	111543440	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111543440A>G	uc003pus.2	+	6					SLC16A10_uc003put.2_3'UTR	NM_018593	NP_061063			solute carrier family 16, member 10						aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)														---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111628643	111628643	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111628643C>T	uc003puy.3	-	31	9496	c.9173G>A	c.(9172-9174)CGG>CAG	p.R3058Q	REV3L_uc003pux.3_Missense_Mutation_p.R2980Q|REV3L_uc003puz.3_Missense_Mutation_p.R2980Q|REV3L_uc003puw.3_Missense_Mutation_p.R125Q	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	3058					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111650832	111650832	+	Missense_Mutation	SNP	C	T	T	rs141338934		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111650832C>T	uc003puy.3	-	25	8467	c.8144G>A	c.(8143-8145)CGA>CAA	p.R2715Q	REV3L_uc003pux.3_Missense_Mutation_p.R2637Q|REV3L_uc003puz.3_Missense_Mutation_p.R2637Q|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2715					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
FYN	2534	broad.mit.edu	37	6	112015676	112015676	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112015676C>T	uc003pvj.2	-	11	1515	c.1175G>A	c.(1174-1176)CGA>CAA	p.R392Q	FYN_uc003pvi.2_Missense_Mutation_p.R337Q|FYN_uc003pvk.2_Missense_Mutation_p.R392Q|FYN_uc003pvh.2_Missense_Mutation_p.R389Q|FYN_uc010kdy.1_Missense_Mutation_p.R83Q	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	392	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)													---	---	---	---
ROS1	6098	broad.mit.edu	37	6	117681045	117681045	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117681045T>A	uc003pxp.1	-	23	3774	c.3575A>T	c.(3574-3576)GAT>GTT	p.D1192V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1192	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)				T	GOPC|ROS1	glioblastoma|NSCLC								---	---	---	---
ROS1	6098	broad.mit.edu	37	6	117709040	117709040	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117709040C>T	uc003pxp.1	-	13	2116	c.1917G>A	c.(1915-1917)CTG>CTA	p.L639L	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	639	Fibronectin type-III 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)				T	GOPC|ROS1	glioblastoma|NSCLC								---	---	---	---
SLC35F1	222553	broad.mit.edu	37	6	118588225	118588225	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:118588225A>G	uc003pxx.3	+	4	746	c.545A>G	c.(544-546)AAG>AGG	p.K182R	SLC35F1_uc003pxy.1_5'UTR	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	182					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)														---	---	---	---
C6orf204	387119	broad.mit.edu	37	6	118845081	118845081	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:118845081A>G	uc003pxz.1	-	4	1611	c.1023T>C	c.(1021-1023)GTT>GTC	p.V341V	C6orf204_uc003pya.1_Silent_p.V344V|C6orf204_uc003pyb.2_Silent_p.V341V|C6orf204_uc011ebj.1_Silent_p.V239V|C6orf204_uc003pyc.2_Silent_p.V344V	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	341						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)														---	---	---	---
MCM9	254394	broad.mit.edu	37	6	119252713	119252713	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:119252713T>C	uc003pyh.2	-	2	439	c.176A>G	c.(175-177)AAC>AGC	p.N59S		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	59					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)														---	---	---	---
FAM184A	79632	broad.mit.edu	37	6	119345686	119345686	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:119345686A>G	uc003pyj.2	-	2	800	c.452T>C	c.(451-453)ATA>ACA	p.I151T	FAM184A_uc003pyk.3_Missense_Mutation_p.I31T|FAM184A_uc003pyl.3_Missense_Mutation_p.I31T	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	151	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7																		---	---	---	---
PKIB	5570	broad.mit.edu	37	6	123039072	123039072	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:123039072T>C	uc003pyz.2	+	6	594	c.133T>C	c.(133-135)TTG>CTG	p.L45L	PKIB_uc003pza.2_Silent_p.L45L|PKIB_uc003pzb.2_Silent_p.L45L|PKIB_uc003pzc.2_Silent_p.L52L|PKIB_uc011ebq.1_Silent_p.L45L	NM_181794	NP_861459	Q9C010	IPKB_HUMAN	cAMP-dependent protein kinase inhibitor beta	45							cAMP-dependent protein kinase inhibitor activity				0				GBM - Glioblastoma multiforme(226;0.164)														---	---	---	---
STL	7955	broad.mit.edu	37	6	125233370	125233370	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125233370A>G	uc003pzq.2	-	7		c.1364T>C				NR_026876				Homo sapiens mRNA; cDNA DKFZp451I132 (from clone DKFZp451I132).												0								T	ETV6	B-ALL								---	---	---	---
C6orf174	387104	broad.mit.edu	37	6	127796588	127796588	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127796588G>A	uc003qbd.2	-	6	3448	c.2583C>T	c.(2581-2583)GAC>GAT	p.D861D	C6orf174_uc003qbc.2_Translation_Start_Site	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	861						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129511376	129511376	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129511376T>C	uc003qbn.2	+	11	1599	c.1494T>C	c.(1492-1494)AGT>AGC	p.S498S	LAMA2_uc003qbo.2_Silent_p.S498S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	498	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129649468	129649468	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129649468C>T	uc003qbn.2	+	29	4327	c.4222C>T	c.(4222-4224)CGC>TGC	p.R1408C	LAMA2_uc003qbo.2_Missense_Mutation_p.R1408C	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1408	Laminin EGF-like 14; second part.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129802514	129802514	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129802514C>T	uc003qbn.2	+	54	7784	c.7679C>T	c.(7678-7680)TCC>TTC	p.S2560F	LAMA2_uc003qbo.2_Missense_Mutation_p.S2556F|uc003qbq.2_RNA	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2560	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
MED23	9439	broad.mit.edu	37	6	131911475	131911475	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131911475C>T	uc003qcs.1	-	27	3968	c.3794G>A	c.(3793-3795)CGT>CAT	p.R1265H	MED23_uc003qcq.2_Missense_Mutation_p.R1271H|MED23_uc003qcr.1_Missense_Mutation_p.R120H	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	1265					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)														---	---	---	---
MED23	9439	broad.mit.edu	37	6	131944545	131944545	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131944545A>G	uc003qcs.1	-	5	516	c.342T>C	c.(340-342)CTT>CTC	p.L114L	MED23_uc003qcq.2_Silent_p.L114L|MED23_uc003qct.1_Silent_p.L114L|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	114					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)														---	---	---	---
ENPP3	5169	broad.mit.edu	37	6	132006573	132006573	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132006573A>G	uc003qcu.3	+	14	1537	c.1190A>G	c.(1189-1191)TAC>TGC	p.Y397C	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.Y397C	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	397	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)														---	---	---	---
ENPP1	5167	broad.mit.edu	37	6	132198309	132198309	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132198309T>C	uc011ecf.1	+						ENPP1_uc003qcy.2_Missense_Mutation_p.I264T	NM_006208	NP_006199			ectonucleotide pyrophosphatase/phosphodiesterase						3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)													---	---	---	---
TAAR6	319100	broad.mit.edu	37	6	132892197	132892197	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:132892197A>G	uc011eck.1	+	1	737	c.737A>G	c.(736-738)AAA>AGA	p.K246R		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	246	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)														---	---	---	---
VNN2	8875	broad.mit.edu	37	6	133079002	133079002	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133079002T>G	uc003qdt.2	-	1	32	c.21A>C	c.(19-21)CCA>CCC	p.P7P	VNN2_uc003qds.2_5'Flank|VNN2_uc010kgb.2_Silent_p.P7P|VNN2_uc003qdv.2_Intron	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	7					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)														---	---	---	---
ALDH8A1	64577	broad.mit.edu	37	6	135239850	135239850	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135239850C>T	uc003qew.2	-	7	1220	c.1167G>A	c.(1165-1167)ACG>ACA	p.T389T	ALDH8A1_uc003qex.2_Silent_p.T335T|ALDH8A1_uc010kgh.2_Silent_p.T167T|ALDH8A1_uc011ecx.1_Silent_p.T339T	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	389					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)														---	---	---	---
BCLAF1	9774	broad.mit.edu	37	6	136599140	136599140	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136599140A>G	uc003qgx.1	-	4	1132	c.879T>C	c.(877-879)CAT>CAC	p.H293H	BCLAF1_uc003qgw.1_Silent_p.H293H|BCLAF1_uc003qgy.1_Silent_p.H291H|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.H291H	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	293					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)														---	---	---	---
BCLAF1	9774	broad.mit.edu	37	6	136600996	136600996	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136600996G>A	uc003qgx.1	-	3	262	c.9C>T	c.(7-9)CGC>CGT	p.R3R	BCLAF1_uc003qgw.1_Silent_p.R3R|BCLAF1_uc003qgy.1_Silent_p.R3R|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.R3R	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	3					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)														---	---	---	---
MAP7	9053	broad.mit.edu	37	6	136682268	136682268	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136682268G>A	uc003qgz.2	-	12	1822	c.1576C>T	c.(1576-1578)CGC>TGC	p.R526C	MAP7_uc011edf.1_Missense_Mutation_p.R511C|MAP7_uc011edg.1_Missense_Mutation_p.R556C|MAP7_uc010kgu.2_Missense_Mutation_p.R548C|MAP7_uc011edh.1_Missense_Mutation_p.R511C|MAP7_uc010kgv.2_Missense_Mutation_p.R548C|MAP7_uc010kgs.2_Missense_Mutation_p.R380C|MAP7_uc011edi.1_Missense_Mutation_p.R380C|MAP7_uc010kgq.1_Missense_Mutation_p.R432C|MAP7_uc003qha.1_Missense_Mutation_p.R489C	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	526	Potential.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)														---	---	---	---
MAP7	9053	broad.mit.edu	37	6	136732783	136732783	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:136732783T>C	uc003qgz.2	-	3	465	c.219A>G	c.(217-219)CGA>CGG	p.R73R	MAP7_uc011edf.1_Silent_p.R58R|MAP7_uc011edg.1_Silent_p.R95R|MAP7_uc010kgu.2_Silent_p.R95R|MAP7_uc011edh.1_Silent_p.R95R|MAP7_uc010kgv.2_Silent_p.R95R|MAP7_uc010kgs.2_5'UTR|MAP7_uc011edi.1_5'UTR|MAP7_uc010kgq.1_Silent_p.R73R|MAP7_uc003qha.1_Silent_p.R73R|MAP7_uc010kgr.2_Intron|MAP7_uc010kgt.2_Silent_p.R95R	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	73					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)														---	---	---	---
IL20RA	53832	broad.mit.edu	37	6	137329777	137329777	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137329777C>T	uc003qhj.2	-	5	1116	c.683G>A	c.(682-684)CGT>CAT	p.R228H	IL20RA_uc011edl.1_Missense_Mutation_p.R179H|IL20RA_uc003qhk.2_Missense_Mutation_p.R117H|IL20RA_uc003qhi.2_Translation_Start_Site	NM_014432	NP_055247	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha precursor	228	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	receptor activity			ovary(2)|skin(2)	4	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)														---	---	---	---
KIAA1244	57221	broad.mit.edu	37	6	138584111	138584111	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:138584111C>T	uc003qhu.2	+	12	1491	c.1491C>T	c.(1489-1491)AAC>AAT	p.N497N		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	497					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)														---	---	---	---
REPS1	85021	broad.mit.edu	37	6	139262580	139262580	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139262580A>G	uc003qii.2	-	8	1606	c.1027T>C	c.(1027-1029)TTT>CTT	p.F343L	REPS1_uc003qig.3_Missense_Mutation_p.F343L|REPS1_uc011edr.1_Missense_Mutation_p.F343L|REPS1_uc003qij.2_Missense_Mutation_p.F343L|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	343	EF-hand.|EH 2.					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)														---	---	---	---
HECA	51696	broad.mit.edu	37	6	139488248	139488248	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139488248C>T	uc003qin.2	+	2	1384	c.1099C>T	c.(1099-1101)CGC>TGC	p.R367C		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	367					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)														---	---	---	---
TXLNB	167838	broad.mit.edu	37	6	139563930	139563930	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:139563930T>A	uc011eds.1	-	10	1953	c.1788A>T	c.(1786-1788)GGA>GGT	p.G596G		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	596						cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)														---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143091213	143091213	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143091213T>A	uc003qjd.2	-	5	5406	c.4663A>T	c.(4663-4665)AAG>TAG	p.K1555*		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1555	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143093607	143093607	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143093607G>A	uc003qjd.2	-	5	3012	c.2269C>T	c.(2269-2271)CGC>TGC	p.R757C		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	757					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	145095484	145095484	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145095484A>G	uc003qkt.2	+	59	8708	c.8616A>G	c.(8614-8616)CTA>CTG	p.L2872L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2872	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
EPM2A	7957	broad.mit.edu	37	6	145956616	145956616	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:145956616T>C	uc003qkw.2	-	3	840	c.483A>G	c.(481-483)CTA>CTG	p.L161L	EPM2A_uc003qkv.2_Silent_p.L161L|EPM2A_uc010khr.2_Intron|EPM2A_uc003qkx.2_Silent_p.L23L|EPM2A_uc003qku.2_Silent_p.L7L	NM_005670	NP_005661	O95278	EPM2A_HUMAN	laforin isoform a	161					glycogen metabolic process	cytosol|endoplasmic reticulum|nucleus|plasma membrane|polysome	carbohydrate binding|identical protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Ovarian(120;0.162)		OV - Ovarian serous cystadenocarcinoma(155;3.38e-07)|GBM - Glioblastoma multiforme(68;0.0203)														---	---	---	---
FBXO30	84085	broad.mit.edu	37	6	146127309	146127309	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146127309T>C	uc003qla.2	-	2	432	c.233A>G	c.(232-234)GAA>GGA	p.E78G	uc003qky.1_Intron	NM_032145	NP_115521	Q8TB52	FBX30_HUMAN	F-box only protein 30	78	TRAF-type.						ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146267451	146267451	+	Silent	SNP	C	T	T	rs140562619	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146267451C>T	uc003qlf.2	-	7	1638	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	SHPRH_uc003qld.2_Silent_p.P413P|SHPRH_uc003qle.2_Silent_p.P413P|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Silent_p.P302P	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	413					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
SASH1	23328	broad.mit.edu	37	6	148865705	148865705	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:148865705C>T	uc003qme.1	+	18	3574	c.3099C>T	c.(3097-3099)AGC>AGT	p.S1033S	SASH1_uc011eeb.1_Silent_p.S794S|SASH1_uc003qmf.1_Silent_p.S443S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	1033	Pro-rich.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)														---	---	---	---
C6orf72	116254	broad.mit.edu	37	6	149911891	149911891	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149911891G>A	uc003qmq.1	+	8	937	c.910G>A	c.(910-912)GTC>ATC	p.V304I		NM_138785	NP_620140	Q9NU53	CF072_HUMAN	hypothetical protein LOC116254 precursor	304	Cytoplasmic (Potential).					integral to membrane					0		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;9.66e-12)|GBM - Glioblastoma multiforme(68;0.171)														---	---	---	---
LATS1	9113	broad.mit.edu	37	6	150004383	150004383	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150004383A>G	uc003qmu.1	-	4	2390	c.1842T>C	c.(1840-1842)CCT>CCC	p.P614P	LATS1_uc010kif.1_Silent_p.P509P|LATS1_uc003qmv.1_Silent_p.P614P|LATS1_uc003qmw.2_Silent_p.P614P|LATS1_uc010kig.1_Silent_p.P509P	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	614	Interaction with YAP1.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)														---	---	---	---
LATS1	9113	broad.mit.edu	37	6	150004895	150004895	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150004895A>G	uc003qmu.1	-	4	1878	c.1330T>C	c.(1330-1332)TCC>CCC	p.S444P	LATS1_uc010kif.1_Missense_Mutation_p.S339P|LATS1_uc003qmv.1_Missense_Mutation_p.S444P|LATS1_uc003qmw.2_Missense_Mutation_p.S444P|LATS1_uc010kig.1_Missense_Mutation_p.S339P	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	444					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)														---	---	---	---
PLEKHG1	57480	broad.mit.edu	37	6	151130245	151130245	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151130245T>C	uc003qny.1	+	9	1229	c.917T>C	c.(916-918)ATA>ACA	p.I306T	PLEKHG1_uc011eel.1_Missense_Mutation_p.I346T|PLEKHG1_uc011eem.1_Missense_Mutation_p.I365T|PLEKHG1_uc003qnz.2_Missense_Mutation_p.I306T	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	306					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)														---	---	---	---
AKAP12	9590	broad.mit.edu	37	6	151671447	151671447	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151671447G>A	uc011eep.1	+	4	2161	c.1921G>A	c.(1921-1923)GCT>ACT	p.A641T	AKAP12_uc003qoe.2_Missense_Mutation_p.A641T|AKAP12_uc003qof.2_Missense_Mutation_p.A543T|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.A536T	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	641					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)														---	---	---	---
AKAP12	9590	broad.mit.edu	37	6	151674211	151674211	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151674211T>C	uc011eep.1	+	4	4925	c.4685T>C	c.(4684-4686)GTA>GCA	p.V1562A	AKAP12_uc003qoe.2_Missense_Mutation_p.V1562A|AKAP12_uc003qof.2_Missense_Mutation_p.V1464A|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.V1457A	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1562					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)														---	---	---	---
C6orf97	80129	broad.mit.edu	37	6	151917602	151917602	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:151917602A>C	uc003qol.2	+	9	1689	c.1600A>C	c.(1600-1602)ACC>CCC	p.T534P		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	534	Potential.										0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152643022	152643022	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152643022C>T	uc010kiw.2	-	83	16520	c.15918_splice	c.e83-1	p.N5306_splice	SYNE1_uc003qot.3_Splice_Site_p.N5235_splice|SYNE1_uc003qou.3_Splice_Site_p.N5306_splice|SYNE1_uc010kiz.2_Splice_Site_p.N1061_splice	NM_182961	NP_892006			spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152786491	152786491	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152786491T>C	uc010kiw.2	-	18	2436	c.1834A>G	c.(1834-1836)ATC>GTC	p.I612V	SYNE1_uc003qot.3_Missense_Mutation_p.I619V|SYNE1_uc003qou.3_Missense_Mutation_p.I612V|SYNE1_uc010kjb.1_Missense_Mutation_p.I595V|SYNE1_uc003qpa.1_Missense_Mutation_p.I612V|SYNE1_uc003qow.2_5'Flank|SYNE1_uc003qox.1_Missense_Mutation_p.I128V|SYNE1_uc003qoz.2_Missense_Mutation_p.I44V|SYNE1_uc003qoy.2_Missense_Mutation_p.I179V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	612	Cytoplasmic (Potential).|HAT 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152831446	152831446	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152831446C>T	uc010kiw.2	-	8	1065	c.463G>A	c.(463-465)GTG>ATG	p.V155M	SYNE1_uc003qot.3_Missense_Mutation_p.V162M|SYNE1_uc003qou.3_Missense_Mutation_p.V155M|SYNE1_uc010kjb.1_Missense_Mutation_p.V155M|SYNE1_uc003qpa.1_Missense_Mutation_p.V155M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	155	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
MTRF1L	54516	broad.mit.edu	37	6	153315653	153315653	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:153315653T>C	uc003qpi.3	-	4	787	c.682A>G	c.(682-684)ACT>GCT	p.T228A	MTRF1L_uc003qpl.3_Missense_Mutation_p.T228A|MTRF1L_uc011efa.1_Missense_Mutation_p.T192A|MTRF1L_uc003qpj.3_Missense_Mutation_p.T86A|MTRF1L_uc003qpk.3_Missense_Mutation_p.T192A	NM_019041	NP_061914	Q9UGC7	RF1ML_HUMAN	mitochondrial translational release factor	228						mitochondrion	translation release factor activity, codon specific				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.24e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0888)														---	---	---	---
RBM16	22828	broad.mit.edu	37	6	155114029	155114029	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155114029T>C	uc003qqa.2	+	6	626	c.394T>C	c.(394-396)TTG>CTG	p.L132L	RBM16_uc011efj.1_Silent_p.L198L|RBM16_uc011efk.1_Silent_p.L177L|RBM16_uc003qpz.2_Silent_p.L132L|RBM16_uc010kji.2_Silent_p.L153L	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	132	CID.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)														---	---	---	---
ARID1B	57492	broad.mit.edu	37	6	157522190	157522190	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157522190C>G	uc003qqn.2	+	18	4560	c.4408C>G	c.(4408-4410)CCC>GCC	p.P1470A	ARID1B_uc003qqo.2_Missense_Mutation_p.P1430A|ARID1B_uc003qqp.2_Missense_Mutation_p.P1417A	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1475	Pro-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)														---	---	---	---
ARID1B	57492	broad.mit.edu	37	6	157527749	157527749	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157527749A>G	uc003qqn.2	+	20	5572	c.5420A>G	c.(5419-5421)GAC>GGC	p.D1807G	ARID1B_uc003qqo.2_Missense_Mutation_p.D1767G|ARID1B_uc003qqp.2_Missense_Mutation_p.D1754G	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1812					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)														---	---	---	---
C6orf35	729515	broad.mit.edu	37	6	157739925	157739925	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:157739925C>T	uc003sih.3	-	3	479	c.216G>A	c.(214-216)CCG>CCA	p.P72P		NM_018452	NP_060922	Q9NWH2	CF035_HUMAN	hypothetical protein LOC729515	72						integral to membrane					0																		---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158483115	158483115	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158483115T>C	uc003qqx.1	+	8	1121	c.1046T>C	c.(1045-1047)TTG>TCG	p.L349S	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.L349S|SYNJ2_uc003qqy.1_Missense_Mutation_p.L62S|SYNJ2_uc011efn.1_Missense_Mutation_p.L277S|SYNJ2_uc010kjo.1_Missense_Mutation_p.L298S|SYNJ2_uc003qqz.1_5'UTR	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	349	SAC.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
FNDC1	84624	broad.mit.edu	37	6	159642717	159642717	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:159642717G>A	uc010kjv.2	+	6	955	c.755G>A	c.(754-756)CGA>CAA	p.R252Q	FNDC1_uc010kjw.1_Missense_Mutation_p.R200Q	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	252						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)														---	---	---	---
ACAT2	39	broad.mit.edu	37	6	160197274	160197274	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160197274A>G	uc010kjy.2	+	6	858	c.727A>G	c.(727-729)ACG>GCG	p.T243A	ACAT2_uc011efw.1_Missense_Mutation_p.T272A	NM_005891	NP_005882	Q9BWD1	THIC_HUMAN	acetyl-Coenzyme A acetyltransferase 2	243						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)														---	---	---	---
TCP1	6950	broad.mit.edu	37	6	160206922	160206922	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160206922A>G	uc003qsr.2	-						TCP1_uc003qss.2_Intron|TCP1_uc010kjz.2_Intron|TCP1_uc003qst.2_Intron|SNORA29_uc003qsv.1_5'Flank	NM_030752	NP_110379			T-complex protein 1 isoform a						'de novo' posttranslational protein folding|tubulin complex assembly	cell junction|Golgi apparatus	ATP binding|unfolded protein binding			breast(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(65;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160466820	160466820	+	Silent	SNP	C	T	T	rs139665293		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160466820C>T	uc003qta.2	+	14	1957	c.1809C>T	c.(1807-1809)GGC>GGT	p.G603G		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	603	4.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160494304	160494304	+	Missense_Mutation	SNP	G	A	A	rs140858283		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160494304G>A	uc003qta.2	+	34	4898	c.4750G>A	c.(4750-4752)GTG>ATG	p.V1584M		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1584	11.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
SLC22A1	6580	broad.mit.edu	37	6	160560826	160560826	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160560826C>T	uc003qtc.2	+	7	1308	c.1203C>T	c.(1201-1203)GGC>GGT	p.G401G	SLC22A1_uc003qtd.2_Silent_p.G401G	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	401	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)														---	---	---	---
SLC22A3	6581	broad.mit.edu	37	6	160819102	160819102	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160819102A>G	uc003qti.2	+	2	548	c.521A>G	c.(520-522)TAT>TGT	p.Y174C	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	174						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)														---	---	---	---
SLC22A3	6581	broad.mit.edu	37	6	160858109	160858109	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160858109T>G	uc003qti.2	+	7	1181	c.1154T>G	c.(1153-1155)ATC>AGC	p.I385S	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	385	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)														---	---	---	---
LPA	4018	broad.mit.edu	37	6	161007564	161007564	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161007564G>A	uc003qtl.2	-	26	4166	c.4046C>T	c.(4045-4047)ACG>ATG	p.T1349M		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3857	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)													---	---	---	---
PLG	5340	broad.mit.edu	37	6	161162399	161162399	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161162399T>C	uc003qtm.3	+	17	2138	c.2075T>C	c.(2074-2076)GTG>GCG	p.V692A		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	692	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)													---	---	---	---
MAP3K4	4216	broad.mit.edu	37	6	161523764	161523764	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161523764C>T	uc003qtn.2	+	19	3951	c.3809C>T	c.(3808-3810)TCC>TTC	p.S1270F	MAP3K4_uc010kkc.1_Missense_Mutation_p.S1266F|MAP3K4_uc003qto.2_Missense_Mutation_p.S1220F|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.S723F|MAP3K4_uc003qtp.2_Missense_Mutation_p.S206F|MAP3K4_uc003qtq.2_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1270					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)														---	---	---	---
AGPAT4	56895	broad.mit.edu	37	6	161653160	161653160	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161653160T>C	uc003qtr.1	-	2	313	c.86A>G	c.(85-87)AAC>AGC	p.N29S	AGPAT4_uc003qts.1_5'UTR|AGPAT4_uc011egb.1_Missense_Mutation_p.N29S|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Missense_Mutation_p.N29S|AGPAT4_uc011egd.1_Intron|AGPAT4_uc011ege.1_Missense_Mutation_p.N29S	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	29	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)														---	---	---	---
PACRG	135138	broad.mit.edu	37	6	163149299	163149299	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:163149299A>G	uc003qua.2	+	2	256	c.32A>G	c.(31-33)AAC>AGC	p.N11S	PARK2_uc003qtx.3_5'Flank|PARK2_uc003qty.3_5'Flank|PARK2_uc003qtz.3_5'Flank|PARK2_uc010kke.1_5'Flank|PACRG_uc003qub.2_Missense_Mutation_p.N11S|PACRG_uc003quc.2_Missense_Mutation_p.N11S	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	11											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)														---	---	---	---
C6orf118	168090	broad.mit.edu	37	6	165712998	165712998	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:165712998A>G	uc003qum.3	-						C6orf118_uc011egi.1_Intron	NM_144980	NP_659417			hypothetical protein LOC168090												0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)														---	---	---	---
SMOC2	64094	broad.mit.edu	37	6	168947819	168947819	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:168947819T>C	uc003qws.1	+	6	552	c.532T>C	c.(532-534)TTG>CTG	p.L178L	SMOC2_uc003qwr.1_Silent_p.L189L	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	178					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)														---	---	---	---
SMOC2	64094	broad.mit.edu	37	6	169064767	169064767	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169064767T>C	uc003qws.1	+	12	1319	c.1299T>C	c.(1297-1299)CAT>CAC	p.H433H	SMOC2_uc003qwr.1_Silent_p.H444H|SMOC2_uc011egu.1_Silent_p.H110H	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	433					signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)														---	---	---	---
THBS2	7058	broad.mit.edu	37	6	169621532	169621532	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169621532A>G	uc003qwt.2	-	21	3612	c.3364T>C	c.(3364-3366)TAC>CAC	p.Y1122H		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	1122	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)														---	---	---	---
THBS2	7058	broad.mit.edu	37	6	169625316	169625316	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169625316A>G	uc003qwt.2	-	18	2945	c.2697T>C	c.(2695-2697)GAT>GAC	p.D899D		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	899	TSP type-3 7.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)														---	---	---	---
THBS2	7058	broad.mit.edu	37	6	169625355	169625355	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169625355G>A	uc003qwt.2	-	18	2906	c.2658C>T	c.(2656-2658)GAC>GAT	p.D886D		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	886	TSP type-3 7.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)														---	---	---	---
THBS2	7058	broad.mit.edu	37	6	169648841	169648841	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:169648841C>T	uc003qwt.2	-	4	528	c.280G>A	c.(280-282)GGC>AGC	p.G94S		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	94	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)														---	---	---	---
DLL1	28514	broad.mit.edu	37	6	170592196	170592196	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170592196A>G	uc003qxm.2	-							NM_005618	NP_005609			delta-like 1 precursor						cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)														---	---	---	---
DLL1	28514	broad.mit.edu	37	6	170597560	170597560	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170597560C>T	uc003qxm.2	-	4	907	c.437G>A	c.(436-438)CGC>CAC	p.R146H	DLL1_uc011ehc.1_Missense_Mutation_p.R146H|DLL1_uc003qxn.3_3'UTR	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	146	Extracellular (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)														---	---	---	---
DLL1	28514	broad.mit.edu	37	6	170597811	170597811	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170597811T>C	uc003qxm.2	-						DLL1_uc011ehc.1_Intron|DLL1_uc003qxn.3_3'UTR	NM_005618	NP_005609			delta-like 1 precursor						cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)														---	---	---	---
FAM120B	84498	broad.mit.edu	37	6	170632185	170632185	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170632185G>A	uc003qxp.2	+	3	1861	c.1753G>A	c.(1753-1755)GTC>ATC	p.V585I	FAM120B_uc003qxo.1_Missense_Mutation_p.V585I|FAM120B_uc011ehd.1_Intron	NM_032448	NP_115824	Q96EK7	F120B_HUMAN	family with sequence similarity 120B	585					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			ovary(1)	1		Breast(66;0.000338)|Esophageal squamous(34;0.241)		OV - Ovarian serous cystadenocarcinoma(33;3.94e-22)|BRCA - Breast invasive adenocarcinoma(81;6.47e-06)|GBM - Glioblastoma multiforme(31;0.0899)														---	---	---	---
FAM20C	56975	broad.mit.edu	37	7	195593	195593	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:195593C>T	uc003sip.2	+	2	876	c.645C>T	c.(643-645)CCC>CCT	p.P215P		NM_020223	NP_064608	Q8IXL6	DMP4_HUMAN	family with sequence similarity 20, member C	215						extracellular region					0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.57e-17)|Epithelial(4;1.26e-16)|all cancers(6;4.79e-14)														---	---	---	---
GET4	51608	broad.mit.edu	37	7	930607	930607	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:930607C>T	uc003sjl.1	+	5	601	c.509C>T	c.(508-510)GCG>GTG	p.A170V	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	170					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0																		---	---	---	---
GPER	2852	broad.mit.edu	37	7	1131459	1131459	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1131459A>G	uc010ksd.1	+	2	484	c.95A>G	c.(94-96)AAC>AGC	p.N32S	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.N32S|GPER_uc003ska.1_Missense_Mutation_p.N32S|GPER_uc003skb.2_Missense_Mutation_p.N32S	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	32	Extracellular (Potential).			Missing (in Ref. 7; AAB02736).		endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)														---	---	---	---
FTSJ2	29960	broad.mit.edu	37	7	2278837	2278837	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2278837G>T	uc003slm.2	-						FTSJ2_uc003slk.2_Intron|FTSJ2_uc003sll.2_Intron|FTSJ2_uc003sln.2_Intron|FTSJ2_uc003slo.2_Intron	NM_013393	NP_037525			FtsJ homolog 2						cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)														---	---	---	---
CHST12	55501	broad.mit.edu	37	7	2472497	2472497	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2472497A>G	uc003smc.2	+	2	358	c.223A>G	c.(223-225)AGT>GGT	p.S75G	CHST12_uc003smd.2_Missense_Mutation_p.S75G	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	75	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)														---	---	---	---
TTYH3	80727	broad.mit.edu	37	7	2698073	2698073	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2698073C>T	uc003smp.2	+	12	1591	c.1404C>T	c.(1402-1404)AAC>AAT	p.N468N	TTYH3_uc010ksn.2_Silent_p.N188N|TTYH3_uc003smq.2_Silent_p.N297N	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	468	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)														---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2953031	2953031	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2953031T>C	uc003smv.2	-	22	3313	c.2909A>G	c.(2908-2910)TAC>TGC	p.Y970C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	970					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2979388	2979388	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2979388T>C	uc003smv.2	-	6	1263	c.859A>G	c.(859-861)ATC>GTC	p.I287V		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	287	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
CARD11	84433	broad.mit.edu	37	7	2987388	2987388	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2987388G>A	uc003smv.2	-	3	445	c.41C>T	c.(40-42)ACG>ATG	p.T14M		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	14					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)				Mis		DLBCL								---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4007008	4007008	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4007008A>T	uc003smx.2	+	10	1627	c.1488A>T	c.(1486-1488)ACA>ACT	p.T496T		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	496	Ig-like C2-type 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4198165	4198165	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4198165G>A	uc003smx.2	+	31	4850	c.4711G>A	c.(4711-4713)GTG>ATG	p.V1571M	SDK1_uc010kso.2_Missense_Mutation_p.V847M|SDK1_uc003smy.2_Missense_Mutation_p.V58M	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1571	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4304866	4304866	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4304866A>G	uc003smx.2	+	45	6631	c.6492A>G	c.(6490-6492)GCA>GCG	p.A2164A	SDK1_uc010kso.2_Silent_p.A1420A|SDK1_uc003smy.2_Silent_p.A651A|SDK1_uc003smz.2_Silent_p.A224A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2164	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4308313	4308313	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4308313A>G	uc003smx.2	+	45					SDK1_uc010kso.2_3'UTR|SDK1_uc003smy.2_Silent_p.V657V|SDK1_uc003smz.2_3'UTR	NM_152744	NP_689957			sidekick 1 precursor						cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
KIAA0415	9907	broad.mit.edu	37	7	4830774	4830774	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4830774A>G	uc003sne.2	+	17	2265	c.2182A>G	c.(2182-2184)ACC>GCC	p.T728A	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Missense_Mutation_p.T205A	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	728					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)														---	---	---	---
RADIL	55698	broad.mit.edu	37	7	4856879	4856879	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4856879A>G	uc003snj.1	-	7	1892	c.1719T>C	c.(1717-1719)TAT>TAC	p.Y573Y	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Silent_p.Y78Y|RADIL_uc011jwc.1_Silent_p.Y333Y|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	573	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)														---	---	---	---
RBAK	57786	broad.mit.edu	37	7	5104755	5104755	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5104755A>G	uc010kss.1	+	6	1992	c.1668A>G	c.(1666-1668)GAA>GAG	p.E556E	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Silent_p.E556E	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	556	Interaction with AR.|C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)														---	---	---	---
WIPI2	26100	broad.mit.edu	37	7	5269339	5269339	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5269339A>G	uc003snv.2	+	12	1438	c.1222A>G	c.(1222-1224)ACT>GCT	p.T408A	WIPI2_uc003snw.2_Intron|WIPI2_uc003snx.2_Missense_Mutation_p.T390A|WIPI2_uc003sny.2_Intron|WIPI2_uc010ksv.2_Missense_Mutation_p.T264A|WIPI2_uc003soa.2_Intron|WIPI2_uc003sob.2_Missense_Mutation_p.T151A	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	408					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)														---	---	---	---
SLC29A4	222962	broad.mit.edu	37	7	5338952	5338952	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5338952T>C	uc003sod.2	+	9	1264	c.1103T>C	c.(1102-1104)CTG>CCG	p.L368P	SLC29A4_uc003soc.2_Missense_Mutation_p.L368P|SLC29A4_uc003soe.2_Missense_Mutation_p.L354P|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	368	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)														---	---	---	---
TNRC18	84629	broad.mit.edu	37	7	5401582	5401582	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5401582T>C	uc003soi.3	-	13	4827	c.4478A>G	c.(4477-4479)CAG>CGG	p.Q1493R		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1493	Potential.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)														---	---	---	---
FSCN1	6624	broad.mit.edu	37	7	5643159	5643159	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5643159G>A	uc003sou.2	+	3	1136	c.1022G>A	c.(1021-1023)CGT>CAT	p.R341H	FSCN1_uc003sov.2_Missense_Mutation_p.R63H|FSCN1_uc003sow.2_Missense_Mutation_p.R63H	NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	341					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)														---	---	---	---
C7orf28A	51622	broad.mit.edu	37	7	5959509	5959509	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5959509C>T	uc003spf.2	+	12	1108	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	340						lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)														---	---	---	---
ZDHHC4	55146	broad.mit.edu	37	7	6624663	6624663	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6624663T>C	uc003sqi.2	+	8	871	c.513T>C	c.(511-513)TGT>TGC	p.C171C	ZDHHC4_uc003sql.2_Silent_p.C171C|ZDHHC4_uc003sqh.2_Silent_p.C171C|ZDHHC4_uc003sqj.2_Silent_p.C171C|ZDHHC4_uc003sqk.2_Silent_p.C171C|ZDHHC4_uc003sqm.2_Silent_p.C171C	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	171	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)														---	---	---	---
C7orf28B	221960	broad.mit.edu	37	7	6844657	6844657	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6844657G>A	uc003sqx.1	-	12	1051	c.1018C>T	c.(1018-1020)CGA>TGA	p.R340*	C7orf28B_uc011jxd.1_Nonsense_Mutation_p.R197*	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960	340						lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)														---	---	---	---
C7orf28B	221960	broad.mit.edu	37	7	6862932	6862932	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6862932C>T	uc003sqx.1	-						C7orf28B_uc011jxd.1_Intron|C7orf28B_uc003sqy.1_3'UTR	NM_198097	NP_932765			hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)														---	---	---	---
COL28A1	340267	broad.mit.edu	37	7	7410437	7410437	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7410437C>T	uc003src.1	-	33	3102	c.2985G>A	c.(2983-2985)TCG>TCA	p.S995S	COL28A1_uc011jxe.1_Silent_p.S678S	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	995					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)														---	---	---	---
COL28A1	340267	broad.mit.edu	37	7	7514247	7514247	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7514247T>C	uc003src.1	-	15	1404	c.1287A>G	c.(1285-1287)TCA>TCG	p.S429S	COL28A1_uc011jxe.1_Silent_p.S112S|COL28A1_uc003srd.2_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	429					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)														---	---	---	---
COL28A1	340267	broad.mit.edu	37	7	7571101	7571101	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7571101T>C	uc003src.1	-	3	676	c.559A>G	c.(559-561)ACC>GCC	p.T187A	COL28A1_uc011jxe.1_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	187	VWFA 1.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11415490	11415490	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11415490T>C	uc003ssf.3	-	27	5157	c.4905A>G	c.(4903-4905)AAA>AAG	p.K1635K	uc003ssb.2_Intron|THSD7A_uc003ssd.3_Silent_p.K139K	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1635	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11676323	11676323	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11676323A>G	uc003ssf.3	-	2	708	c.456T>C	c.(454-456)GGT>GGC	p.G152G		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	152	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21598618	21598618	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21598618T>C	uc003svc.2	+	3	723	c.692_splice	c.e3+2	p.K231_splice		NM_003777	NP_003768			dynein, axonemal, heavy chain 11						microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21744053	21744053	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21744053T>C	uc003svc.2	+	39	6327	c.6296T>C	c.(6295-6297)GTA>GCA	p.V2099A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2099					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
DNAH11	8701	broad.mit.edu	37	7	21934625	21934625	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21934625A>G	uc003svc.2	+							NM_003777	NP_003768			dynein, axonemal, heavy chain 11						microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15														Kartagener_syndrome				---	---	---	---
C7orf30	115416	broad.mit.edu	37	7	23340583	23340583	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23340583A>G	uc003swd.1	+	2	414	c.382A>G	c.(382-384)AGT>GGT	p.S128G		NM_138446	NP_612455	Q96EH3	CG030_HUMAN	hypothetical protein LOC115416	128						mitochondrion					0			GBM - Glioblastoma multiforme(13;0.154)															---	---	---	---
IGF2BP3	10643	broad.mit.edu	37	7	23387308	23387308	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23387308C>T	uc003swg.2	-	7	995	c.729G>A	c.(727-729)TCG>TCA	p.S243S	IGF2BP3_uc003swf.2_5'UTR	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	243	KH 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2																		---	---	---	---
OSBPL3	26031	broad.mit.edu	37	7	24881939	24881939	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:24881939C>T	uc003sxf.2	-	13	1765	c.1360G>A	c.(1360-1362)GCT>ACT	p.A454T	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.A418T|OSBPL3_uc003sxh.2_Missense_Mutation_p.A423T|OSBPL3_uc003sxi.2_Missense_Mutation_p.A387T|OSBPL3_uc003sxj.1_Missense_Mutation_p.A183T|OSBPL3_uc003sxk.1_Missense_Mutation_p.A152T	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	454					lipid transport		lipid binding|protein binding			skin(1)	1																		---	---	---	---
HOXA7	3204	broad.mit.edu	37	7	27195919	27195919	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27195919G>A	uc003sys.2	-	1	378	c.246C>T	c.(244-246)TGC>TGT	p.C82C		NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	82					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0																		---	---	---	---
TRIL	9865	broad.mit.edu	37	7	28996503	28996503	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:28996503A>G	uc003szt.2	-	3	1527	c.1160T>C	c.(1159-1161)TTC>TCC	p.F387S	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	387	Extracellular (Potential).|LRRCT.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0																		---	---	---	---
SCRN1	9805	broad.mit.edu	37	7	29980470	29980470	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29980470A>G	uc010kvp.2	-	4	771	c.567T>C	c.(565-567)AGT>AGC	p.S189S	SCRN1_uc011jzy.1_Silent_p.S121S|SCRN1_uc003tak.2_Silent_p.S189S|SCRN1_uc011jzz.1_Silent_p.S189S|SCRN1_uc011kaa.1_Silent_p.S209S|SCRN1_uc011jzw.1_Intron|SCRN1_uc011jzx.1_Intron	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	189					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2																		---	---	---	---
SCRN1	9805	broad.mit.edu	37	7	29983717	29983717	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29983717A>G	uc010kvp.2	-	3	624	c.420T>C	c.(418-420)GGT>GGC	p.G140G	SCRN1_uc011jzy.1_Silent_p.G72G|SCRN1_uc003tak.2_Silent_p.G140G|SCRN1_uc011jzz.1_Silent_p.G140G|SCRN1_uc011kaa.1_Silent_p.G160G|SCRN1_uc011jzw.1_Silent_p.G72G|SCRN1_uc011jzx.1_Intron	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	140					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2																		---	---	---	---
PLEKHA8	84725	broad.mit.edu	37	7	30094382	30094382	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30094382A>G	uc003tam.1	+	8	945	c.854A>G	c.(853-855)AAC>AGC	p.N285S	PLEKHA8_uc003tao.2_Missense_Mutation_p.N169S|PLEKHA8_uc003tap.1_Missense_Mutation_p.N285S|PLEKHA8_uc003tan.2_Missense_Mutation_p.N285S	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	285					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4																		---	---	---	---
FAM188B	84182	broad.mit.edu	37	7	30825490	30825490	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30825490T>C	uc003tbt.2	+	4	622	c.545T>C	c.(544-546)ATA>ACA	p.I182T	FAM188B_uc010kwe.2_Missense_Mutation_p.I153T	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	182											0																		---	---	---	---
FAM188B	84182	broad.mit.edu	37	7	30931599	30931599	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30931599C>T	uc003tbt.2	+	18	2330	c.2253C>T	c.(2251-2253)AAC>AAT	p.N751N	FAM188B_uc010kwe.2_Silent_p.N722N|AQP1_uc011kac.1_Intron|FAM188B_uc003tbu.2_Silent_p.N271N	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	751											0																		---	---	---	---
KBTBD2	25948	broad.mit.edu	37	7	32910428	32910428	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32910428A>G	uc003tdb.2	-	4	1060	c.401T>C	c.(400-402)GTA>GCA	p.V134A	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	134											0			GBM - Glioblastoma multiforme(11;0.0499)															---	---	---	---
KBTBD2	25948	broad.mit.edu	37	7	32914664	32914664	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:32914664A>G	uc003tdb.2	-	3	935	c.276T>C	c.(274-276)GGT>GGC	p.G92G	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	92	BTB.										0			GBM - Glioblastoma multiforme(11;0.0499)															---	---	---	---
RP9	6100	broad.mit.edu	37	7	33140139	33140139	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33140139T>C	uc003tdm.2	-							NM_203288	NP_976033			retinitis pigmentosa 9						RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)															---	---	---	---
BBS9	27241	broad.mit.edu	37	7	33303903	33303903	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33303903T>C	uc003tdn.1	+	7	1132	c.619T>C	c.(619-621)TAC>CAC	p.Y207H	BBS9_uc003tdo.1_Missense_Mutation_p.Y207H|BBS9_uc003tdp.1_Missense_Mutation_p.Y207H|BBS9_uc003tdq.1_Missense_Mutation_p.Y207H|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.Y207H|BBS9_uc011kao.1_Missense_Mutation_p.Y85H	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	207					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)											Bardet-Biedl_syndrome				---	---	---	---
ANLN	54443	broad.mit.edu	37	7	36462243	36462243	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:36462243T>C	uc003tff.2	+	14	2505	c.2301T>C	c.(2299-2301)ACT>ACC	p.T767T	ANLN_uc011kaz.1_Silent_p.T679T|ANLN_uc003tfg.2_Silent_p.T730T|ANLN_uc010kxe.2_Silent_p.T729T	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	767	Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3																		---	---	---	---
ANLN	54443	broad.mit.edu	37	7	36465653	36465653	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:36465653T>C	uc003tff.2	+						ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Intron|ANLN_uc010kxe.2_Intron	NM_018685	NP_061155			anillin, actin binding protein						cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3																		---	---	---	---
ELMO1	9844	broad.mit.edu	37	7	37354480	37354480	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:37354480T>C	uc003tfk.1	-	4	473	c.166A>G	c.(166-168)AGT>GGT	p.S56G	ELMO1_uc010kxg.1_Missense_Mutation_p.S56G	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	56					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	38398364	38398364	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38398364A>G	uc003tgp.1	+						uc003tgr.2_Missense_Mutation_p.S35P					Homo sapiens cDNA FLJ43658 fis, clone SYNOV4004184.																														---	---	---	---
AMPH	273	broad.mit.edu	37	7	38505843	38505843	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38505843A>G	uc003tgu.2	-	8	665	c.596T>C	c.(595-597)GTT>GCT	p.V199A	AMPH_uc003tgv.2_Missense_Mutation_p.V199A|AMPH_uc003tgt.2_5'Flank	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	199	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5																		---	---	---	---
VPS41	27072	broad.mit.edu	37	7	38765894	38765894	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:38765894A>G	uc003tgy.2	-	29	2543	c.2517T>C	c.(2515-2517)AGT>AGC	p.S839S	VPS41_uc003tgz.2_Silent_p.S814S|VPS41_uc010kxn.2_Silent_p.S750S|VPS41_uc003tgx.2_RNA	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	839	RING-type; atypical.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39500291	39500291	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39500291G>A	uc003thb.1	+	9	1590	c.1548G>A	c.(1546-1548)GCG>GCA	p.A516A		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	516	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39503921	39503921	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39503921C>T	uc003thb.1	+	10	1754	c.1712C>T	c.(1711-1713)GCC>GTC	p.A571V		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	571	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
INHBA	3624	broad.mit.edu	37	7	41729279	41729279	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:41729279T>C	uc003thq.2	-	2	1485	c.1250A>G	c.(1249-1251)AAC>AGC	p.N417S	INHBA_uc003thr.2_Missense_Mutation_p.N417S	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	417					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6															TSP Lung(11;0.080)			---	---	---	---
CAMK2B	816	broad.mit.edu	37	7	44260472	44260472	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44260472C>A	uc003tkq.2	-	21	1836	c.1626G>T	c.(1624-1626)ACG>ACT	p.T542T	CAMK2B_uc003tkp.2_Silent_p.T418T|CAMK2B_uc003tkx.2_Silent_p.T378T|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Silent_p.T394T|CAMK2B_uc003tks.2_Silent_p.T393T|CAMK2B_uc003tku.2_Silent_p.T379T|CAMK2B_uc003tkv.2_Silent_p.T355T|CAMK2B_uc003tkt.2_Silent_p.T394T|CAMK2B_uc003tkw.2_Silent_p.T325T|CAMK2B_uc010kyc.2_Silent_p.T418T|CAMK2B_uc003tkn.2_Silent_p.T175T	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	542					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
NUDCD3	23386	broad.mit.edu	37	7	44507527	44507527	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44507527A>C	uc003tkz.2	-						NUDCD3_uc010kye.2_Intron	NM_015332	NP_056147			NudC domain containing 3												0																		---	---	---	---
DDX56	54606	broad.mit.edu	37	7	44607803	44607803	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44607803G>T	uc003tlg.2	-	12	2046	c.1403C>A	c.(1402-1404)CCT>CAT	p.P468H	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.P404H|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.P428H	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	468					rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
ZMIZ2	83637	broad.mit.edu	37	7	44802571	44802571	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44802571A>T	uc003tlr.2	+	12	1811	c.1688A>T	c.(1687-1689)CAC>CTC	p.H563L	ZMIZ2_uc003tlq.2_Missense_Mutation_p.H505L|ZMIZ2_uc003tls.2_Missense_Mutation_p.H537L|ZMIZ2_uc003tlt.2_Missense_Mutation_p.H186L|ZMIZ2_uc010kyj.2_Missense_Mutation_p.H85L|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	563					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5																		---	---	---	---
MYO1G	64005	broad.mit.edu	37	7	45005794	45005794	+	Missense_Mutation	SNP	C	T	T	rs145905005	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45005794C>T	uc003tmh.2	-	16	2179	c.2035G>A	c.(2035-2037)GGG>AGG	p.G679R	MYO1G_uc003tmf.2_Missense_Mutation_p.G122R|MYO1G_uc003tmg.2_Missense_Mutation_p.G441R|MYO1G_uc010kym.2_Missense_Mutation_p.G564R|MYO1G_uc003tmi.1_3'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	679	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
ADCY1	107	broad.mit.edu	37	7	45717522	45717522	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45717522A>G	uc003tne.3	+	9	1678	c.1660A>G	c.(1660-1662)ACC>GCC	p.T554A		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	554	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
IGFBP1	3484	broad.mit.edu	37	7	45930221	45930221	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:45930221G>A	uc003tnp.2	+	2	717	c.424G>A	c.(424-426)GCC>ACC	p.A142T	IGFBP1_uc003tno.3_Missense_Mutation_p.A142T|IGFBP1_uc010kyn.2_Missense_Mutation_p.A142T	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	142						extracellular space	insulin-like growth factor binding			lung(1)	1																OREG0018048	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TNS3	64759	broad.mit.edu	37	7	47479116	47479116	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47479116A>G	uc003tnv.2	-	6	486	c.119T>C	c.(118-120)ATG>ACG	p.M40T	TNS3_uc003tnw.2_Missense_Mutation_p.M40T|TNS3_uc010kyo.1_Missense_Mutation_p.M40T	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	40	Phosphatase tensin-type.					focal adhesion	protein binding			ovary(4)	4																		---	---	---	---
PKD1L1	168507	broad.mit.edu	37	7	47947666	47947666	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47947666C>T	uc003tny.1	-							NM_138295	NP_612152			polycystin-1L1						cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11																		---	---	---	---
HUS1	3364	broad.mit.edu	37	7	48018405	48018405	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48018405T>C	uc003tod.1	-	2	191	c.61A>G	c.(61-63)AAC>GAC	p.N21D	HUS1_uc003toe.1_Missense_Mutation_p.N21D|HUS1_uc011kce.1_RNA	NM_004507	NP_004498	O60921	HUS1_HUMAN	HUS1 checkpoint protein	21					DNA damage checkpoint|DNA replication	Golgi apparatus|nucleolus|nucleoplasm	protein binding			ovary(2)|lung(2)|kidney(1)	5		Breast(660;0.00139)											Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48313721	48313721	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48313721T>C	uc003toq.2	+	17	4483	c.4458T>C	c.(4456-4458)TTT>TTC	p.F1486F	ABCA13_uc010kyr.2_Silent_p.F989F	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1486					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48522768	48522768	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48522768T>C	uc003toq.2	+						ABCA13_uc010kys.1_Intron|ABCA13_uc010kyt.1_Intron|ABCA13_uc010kyu.1_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
IKZF1	10320	broad.mit.edu	37	7	50467961	50467961	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50467961A>G	uc003tow.3	+	9	1364	c.1196A>G	c.(1195-1197)GAC>GGC	p.D399G	IKZF1_uc003tox.3_Missense_Mutation_p.D357G|IKZF1_uc003toy.3_Missense_Mutation_p.D357G|IKZF1_uc011kck.1_Missense_Mutation_p.D312G|IKZF1_uc003toz.3_Missense_Mutation_p.D369G|IKZF1_uc010kyx.2_Missense_Mutation_p.D139G|IKZF1_uc003tpa.3_Missense_Mutation_p.D141G	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	399					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)						D		ALL								---	---	---	---
COBL	23242	broad.mit.edu	37	7	51095667	51095667	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:51095667G>A	uc003tpr.3	-	10	3311	c.3126C>T	c.(3124-3126)CGC>CGT	p.R1042R	COBL_uc003tps.2_Silent_p.R1099R|COBL_uc011kcl.1_Silent_p.R1042R|COBL_uc003tpp.3_Silent_p.R828R|COBL_uc003tpq.3_Silent_p.R983R|COBL_uc003tpo.3_Silent_p.R584R	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1042										skin(3)|ovary(2)	5	Glioma(55;0.08)																	---	---	---	---
COBL	23242	broad.mit.edu	37	7	51096316	51096316	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:51096316C>T	uc003tpr.3	-	10	2662	c.2477G>A	c.(2476-2478)CGG>CAG	p.R826Q	COBL_uc003tps.2_Missense_Mutation_p.R883Q|COBL_uc011kcl.1_Missense_Mutation_p.R826Q|COBL_uc003tpp.3_Missense_Mutation_p.R612Q|COBL_uc003tpq.3_Missense_Mutation_p.R767Q|COBL_uc003tpo.3_Missense_Mutation_p.R368Q	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	826										skin(3)|ovary(2)	5	Glioma(55;0.08)																	---	---	---	---
POM121L12	285877	broad.mit.edu	37	7	53103642	53103642	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:53103642T>C	uc003tpz.2	+	1	294	c.278T>C	c.(277-279)GTC>GCC	p.V93A		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	93											0																		---	---	---	---
EGFR	1956	broad.mit.edu	37	7	55220349	55220349	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55220349G>A	uc003tqk.2	+	6	985	c.739G>A	c.(739-741)GAC>AAC	p.D247N	EGFR_uc003tqh.2_Missense_Mutation_p.D247N|EGFR_uc003tqi.2_Missense_Mutation_p.D247N|EGFR_uc003tqj.2_Missense_Mutation_p.D247N|EGFR_uc010kzg.1_Missense_Mutation_p.D202N|EGFR_uc011kco.1_Missense_Mutation_p.D194N|EGFR_uc003tql.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	247	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---	---
CCT6A	908	broad.mit.edu	37	7	56123451	56123451	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56123451T>C	uc003trl.1	+	4	635	c.471T>C	c.(469-471)CGT>CGC	p.R157R	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Silent_p.R112R|CCT6A_uc011kcu.1_Silent_p.R126R	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	157					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
CCT6A	908	broad.mit.edu	37	7	56128609	56128609	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56128609T>C	uc003trl.1	+	11	1487	c.1323T>C	c.(1321-1323)GCT>GCC	p.A441A	PSPH_uc003trj.2_Intron|CCT6A_uc003trm.1_Silent_p.A396A|CCT6A_uc011kcu.1_Silent_p.A410A	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	441					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
PHKG1	5260	broad.mit.edu	37	7	56148962	56148962	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56148962G>A	uc003trz.1	-	10	1144	c.949C>T	c.(949-951)CGG>TGG	p.R317W	PSPH_uc003trj.2_Intron|PHKG1_uc003try.1_Missense_Mutation_p.R211W|PHKG1_uc011kdb.1_Missense_Mutation_p.R349W|PHKG1_uc011kdc.1_Missense_Mutation_p.R308W|PHKG1_uc011kdd.1_Missense_Mutation_p.R263W	NM_006213	NP_006204	Q16816	PHKG1_HUMAN	phosphorylase kinase gamma subunit 1	317	Calmodulin-binding (domain-N).				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			large_intestine(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
ZNF117	51351	broad.mit.edu	37	7	64439903	64439903	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64439903A>G	uc003ttr.2	-	4	1331	c.46T>C	c.(46-48)TAT>CAT	p.Y16H		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	16						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)																---	---	---	---
ZNF92	168374	broad.mit.edu	37	7	64863286	64863286	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64863286C>T	uc003ttz.2	+	4	402	c.259C>T	c.(259-261)CCA>TCA	p.P87S	ZNF92_uc003tua.2_Missense_Mutation_p.P18S|ZNF92_uc010kzu.2_Missense_Mutation_p.P55S|ZNF92_uc003tub.2_Missense_Mutation_p.P11S	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	87						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)																---	---	---	---
VKORC1L1	154807	broad.mit.edu	37	7	65419289	65419289	+	3'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65419289G>A	uc003tul.2	+	3					VKORC1L1_uc011kds.1_Silent_p.T141T|VKORC1L1_uc003tum.1_5'Flank	NM_173517	NP_775788			vitamin K epoxide reductase complex, subunit							integral to membrane					0		Lung NSC(55;0.197)			Menadione(DB00170)|Warfarin(DB00682)													---	---	---	---
KCTD7	154881	broad.mit.edu	37	7	66104004	66104004	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66104004G>A	uc003tve.2	+	4	817	c.655G>A	c.(655-657)GGG>AGG	p.G219R	RABGEF1_uc003tvf.2_Intron|KCTD7_uc003tvd.3_Missense_Mutation_p.G219R	NM_153033	NP_694578	Q96MP8	KCTD7_HUMAN	potassium channel tetramerisation domain	219						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
C7orf42	55069	broad.mit.edu	37	7	66413599	66413599	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66413599G>A	uc003tvk.2	+	4	778	c.514G>A	c.(514-516)GCC>ACC	p.A172T	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Missense_Mutation_p.A172T	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	172						integral to membrane				ovary(1)	1																		---	---	---	---
TYW1	55253	broad.mit.edu	37	7	66483036	66483036	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66483036G>A	uc003tvn.2	+	6	916	c.767G>A	c.(766-768)TGC>TAC	p.C256Y	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	256					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)																---	---	---	---
TYW1	55253	broad.mit.edu	37	7	66660204	66660204	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66660204C>A	uc003tvn.2	+	15	2006	c.1857C>A	c.(1855-1857)GCC>GCA	p.A619A	TYW1_uc010lai.2_RNA|TYW1_uc011kef.1_Silent_p.A233A|PMS2L4_uc003tvo.2_Intron	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	619					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)																---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	69064829	69064829	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:69064829T>C	uc003tvw.3	+	1	933	c.190T>C	c.(190-192)TCC>CCC	p.S64P	AUTS2_uc003tvv.3_Missense_Mutation_p.S64P|AUTS2_uc003tvx.3_Missense_Mutation_p.S64P	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	64										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	69064944	69064944	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:69064944T>C	uc003tvw.3	+	1	1048	c.305T>C	c.(304-306)CTG>CCG	p.L102P	AUTS2_uc003tvv.3_Missense_Mutation_p.L102P|AUTS2_uc003tvx.3_Missense_Mutation_p.L102P	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	102										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
AUTS2	26053	broad.mit.edu	37	7	70249919	70249919	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70249919A>C	uc003tvw.3	+						AUTS2_uc003tvx.3_Intron|AUTS2_uc011keg.1_Intron	NM_015570	NP_056385			autism susceptibility candidate 2 isoform 1											ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)														---	---	---	---
WBSCR17	64409	broad.mit.edu	37	7	70886037	70886037	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:70886037A>G	uc003tvy.2	+	5	908	c.908A>G	c.(907-909)TAC>TGC	p.Y303C	WBSCR17_uc003tvz.2_Missense_Mutation_p.Y2C	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	303	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)																---	---	---	---
NSUN5	55695	broad.mit.edu	37	7	72717856	72717856	+	Missense_Mutation	SNP	C	T	T	rs3950374		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72717856C>T	uc003txw.2	-	8	1148	c.1112G>A	c.(1111-1113)CGA>CAA	p.R371Q	FKBP6_uc003twz.2_Intron|NSUN5_uc003txv.2_Missense_Mutation_p.R371Q|NSUN5_uc003txx.2_Missense_Mutation_p.R333Q|NSUN5_uc011kev.1_Missense_Mutation_p.R371Q	NM_018044	NP_060514	Q96P11	NSUN5_HUMAN	NOL1/NOP2/Sun domain family, member 5 isoform 2	371							methyltransferase activity				0		Lung NSC(55;0.163)																---	---	---	---
BAZ1B	9031	broad.mit.edu	37	7	72892413	72892413	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72892413T>C	uc003tyc.2	-	7	1723	c.1378A>G	c.(1378-1380)ACA>GCA	p.T460A		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	460	Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)																---	---	---	---
MLXIPL	51085	broad.mit.edu	37	7	73030508	73030508	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73030508C>T	uc003tyn.1	-	2	342	c.294_splice	c.e2-1	p.S98_splice	MLXIPL_uc003tyk.1_Splice_Site_p.S98_splice|MLXIPL_uc003tyl.1_Splice_Site_p.S98_splice|MLXIPL_uc003tym.1_Splice_Site_p.S98_splice|MLXIPL_uc003tyo.1_Splice_Site|MLXIPL_uc003typ.1_Splice_Site_p.S98_splice	NM_032951	NP_116569			Williams Beuren syndrome chromosome region 14						anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)																---	---	---	---
ELN	2006	broad.mit.edu	37	7	73471776	73471776	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73471776G>A	uc003tzw.2	+						RFC2_uc011kfa.1_Intron|ELN_uc011kfe.1_Intron|ELN_uc003tzn.2_Intron|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Intron|ELN_uc003tzt.2_Intron|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Intron|ELN_uc011kff.1_Intron|ELN_uc003tzy.2_Intron	NM_000501	NP_001075224			elastin isoform a precursor						blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						---	---	---	---
ELN	2006	broad.mit.edu	37	7	73474460	73474460	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73474460C>T	uc003tzw.2	+						RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Intron|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Intron|ELN_uc003tzt.2_Intron|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Intron|ELN_uc011kff.1_Intron|ELN_uc003tzy.2_Intron	NM_000501	NP_001075224			elastin isoform a precursor						blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						---	---	---	---
RFC2	5982	broad.mit.edu	37	7	73646517	73646517	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73646517C>T	uc003uaj.2	-	11	1009	c.984G>A	c.(982-984)GCG>GCA	p.A328A	RFC2_uc011kfa.1_RNA|RFC2_uc003uak.2_Silent_p.A294A|RFC2_uc010lbp.2_Silent_p.A257A|RFC2_uc003ual.2_Silent_p.A227A	NM_181471	NP_852136	P35250	RFC2_HUMAN	replication factor C 2 isoform 1	328					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			liver(1)|central_nervous_system(1)	2																		---	---	---	---
POMZP3	22932	broad.mit.edu	37	7	76241116	76241116	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76241116G>A	uc003uft.2	-	5	1107	c.360C>T	c.(358-360)TGC>TGT	p.C120C	uc003ufs.1_Intron|POMZP3_uc003ufu.2_Intron|POMZP3_uc003ufv.2_RNA|POMZP3_uc011kgm.1_RNA	NM_012230	NP_036362	Q6PJE2	POZP3_HUMAN	POMZP3 fusion protein isoform 1	120											0		Myeloproliferative disorder(862;0.204)																---	---	---	---
POMZP3	22932	broad.mit.edu	37	7	76254925	76254925	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76254925T>C	uc003uft.2	-	3	888	c.141A>G	c.(139-141)GTA>GTG	p.V47V	uc003ufs.1_Intron|POMZP3_uc003ufu.2_Silent_p.V47V|POMZP3_uc003ufv.2_RNA|POMZP3_uc011kgm.1_RNA	NM_012230	NP_036362	Q6PJE2	POZP3_HUMAN	POMZP3 fusion protein isoform 1	47											0		Myeloproliferative disorder(862;0.204)																---	---	---	---
POMZP3	22932	broad.mit.edu	37	7	76254929	76254929	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76254929G>C	uc003uft.2	-	3	884	c.137C>G	c.(136-138)ACT>AGT	p.T46S	uc003ufs.1_Intron|POMZP3_uc003ufu.2_Missense_Mutation_p.T46S|POMZP3_uc003ufv.2_RNA|POMZP3_uc011kgm.1_RNA	NM_012230	NP_036362	Q6PJE2	POZP3_HUMAN	POMZP3 fusion protein isoform 1	46											0		Myeloproliferative disorder(862;0.204)																---	---	---	---
CCDC146	57639	broad.mit.edu	37	7	76883847	76883847	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76883847A>G	uc003uga.2	+	5	601	c.474A>G	c.(472-474)ATA>ATG	p.I158M		NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	158										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)																---	---	---	---
PION	54103	broad.mit.edu	37	7	76940744	76940744	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76940744A>G	uc003ugf.2	-	31	2575	c.2496T>C	c.(2494-2496)CAT>CAC	p.H832H	PION_uc011kgo.1_Silent_p.H153H|PION_uc003ugd.2_Silent_p.H226H	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	832					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1																		---	---	---	---
PION	54103	broad.mit.edu	37	7	76941475	76941475	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:76941475A>G	uc003ugf.2	-	29	2395	c.2316T>C	c.(2314-2316)AGT>AGC	p.S772S	PION_uc011kgo.1_Silent_p.S93S|PION_uc003ugd.2_Silent_p.S166S	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	772					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1																		---	---	---	---
PION	54103	broad.mit.edu	37	7	77035409	77035409	+	Silent	SNP	G	A	A	rs144142632	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77035409G>A	uc003ugf.2	-	2	202	c.123C>T	c.(121-123)AAC>AAT	p.N41N	PION_uc003ugg.1_Translation_Start_Site	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	41					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1																		---	---	---	---
RSBN1L	222194	broad.mit.edu	37	7	77402579	77402579	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:77402579C>T	uc010ldt.1	+	6	1785	c.1741C>T	c.(1741-1743)CGA>TGA	p.R581*	RSBN1L_uc003ugm.2_Nonsense_Mutation_p.R363*	NM_198467	NP_940869	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like	581						nucleus				ovary(1)	1																		---	---	---	---
MAGI2	9863	broad.mit.edu	37	7	78119138	78119138	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:78119138A>G	uc003ugx.2	-	6	1239	c.985T>C	c.(985-987)TCA>CCA	p.S329P	MAGI2_uc003ugy.2_Missense_Mutation_p.S329P|MAGI2_uc010ldx.1_5'UTR|MAGI2_uc010ldy.1_5'UTR|MAGI2_uc011kgr.1_Missense_Mutation_p.S161P|MAGI2_uc011kgs.1_Missense_Mutation_p.S166P	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	329	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)																---	---	---	---
HGF	3082	broad.mit.edu	37	7	81372722	81372722	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81372722C>T	uc003uhl.2	-	7	977	c.812G>A	c.(811-813)TGC>TAC	p.C271Y	HGF_uc003uhm.2_Missense_Mutation_p.C266Y|HGF_uc003uhn.1_Missense_Mutation_p.C271Y|HGF_uc003uho.1_Missense_Mutation_p.C266Y	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	271	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
HGF	3082	broad.mit.edu	37	7	81372723	81372723	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81372723A>G	uc003uhl.2	-	7	976	c.811T>C	c.(811-813)TGC>CGC	p.C271R	HGF_uc003uhm.2_Missense_Mutation_p.C266R|HGF_uc003uhn.1_Missense_Mutation_p.C271R|HGF_uc003uho.1_Missense_Mutation_p.C266R	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	271	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
HGF	3082	broad.mit.edu	37	7	81392115	81392115	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81392115A>T	uc003uhl.2	-	2	327	c.162T>A	c.(160-162)GAT>GAA	p.D54E	HGF_uc003uhm.2_Missense_Mutation_p.D54E|HGF_uc003uhn.1_Missense_Mutation_p.D54E|HGF_uc003uho.1_Missense_Mutation_p.D54E|HGF_uc003uhp.2_Missense_Mutation_p.D54E	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	54	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
CACNA2D1	781	broad.mit.edu	37	7	81611899	81611899	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81611899T>C	uc003uhr.1	-	24	2195	c.1939A>G	c.(1939-1941)ACA>GCA	p.T647A		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	659	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)													---	---	---	---
CACNA2D1	781	broad.mit.edu	37	7	81643727	81643727	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:81643727A>G	uc003uhr.1	-	13	1468	c.1212T>C	c.(1210-1212)TGT>TGC	p.C404C	uc003uhs.1_Intron	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	404	Extracellular (Potential).|VWFA.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)													---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82453563	82453563	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82453563T>C	uc003uhx.2	-	19	14874	c.14585A>G	c.(14584-14586)GAC>GGC	p.D4862G	PCLO_uc003uhv.2_Missense_Mutation_p.D4862G|PCLO_uc003uht.1_Missense_Mutation_p.D304G|PCLO_uc003uhu.1_Missense_Mutation_p.D283G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4724	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
PCLO	27445	broad.mit.edu	37	7	82584247	82584247	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82584247T>C	uc003uhx.2	-	5	6311	c.6022A>G	c.(6022-6024)ACA>GCA	p.T2008A	PCLO_uc003uhv.2_Missense_Mutation_p.T2008A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1939					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7																		---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83037696	83037696	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83037696G>A	uc003uhy.1	-	6	1124	c.658C>T	c.(658-660)CGT>TGT	p.R220C		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	220	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83095872	83095872	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83095872T>A	uc003uhy.1	-	4	848	c.382A>T	c.(382-384)ACA>TCA	p.T128S		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	128	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
SEMA3D	223117	broad.mit.edu	37	7	84649547	84649547	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:84649547A>G	uc003uic.2	-	12	1543	c.1503_splice	c.e12+1	p.K501_splice	SEMA3D_uc010led.2_Splice_Site_p.K501_splice|SEMA3D_uc003uib.2_Splice_Site_p.K140_splice	NM_152754	NP_689967			semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5																		---	---	---	---
GRM3	2913	broad.mit.edu	37	7	86469092	86469092	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86469092C>T	uc003uid.2	+	4	3361	c.2262C>T	c.(2260-2262)TAC>TAT	p.Y754Y	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Silent_p.Y626Y|GRM3_uc010leh.2_Silent_p.Y346Y	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	754	Helical; Name=5; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)													---	---	---	---
DMTF1	9988	broad.mit.edu	37	7	86813838	86813838	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86813838C>T	uc003uih.2	+	11	1272	c.946C>T	c.(946-948)CGC>TGC	p.R316C	DMTF1_uc003uii.2_Missense_Mutation_p.R50C|DMTF1_uc003uij.2_Missense_Mutation_p.R50C|DMTF1_uc011khb.1_Missense_Mutation_p.R228C|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.R316C|DMTF1_uc003uin.2_Missense_Mutation_p.R50C	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	316	H-T-H motif (By similarity).|Interaction with CCND1, CCND2 and CCND3 (By similarity).|HTH myb-type.|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)																	---	---	---	---
DMTF1	9988	broad.mit.edu	37	7	86817425	86817425	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86817425A>G	uc003uih.2	+	13	1545	c.1219A>G	c.(1219-1221)AAA>GAA	p.K407E	DMTF1_uc003uii.2_Missense_Mutation_p.K141E|DMTF1_uc003uij.2_Missense_Mutation_p.K141E|DMTF1_uc011khb.1_Missense_Mutation_p.K319E|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.K407E|DMTF1_uc003uin.2_Missense_Mutation_p.K141E	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	407	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)																	---	---	---	---
ABCB4	5244	broad.mit.edu	37	7	87101978	87101978	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87101978T>C	uc003uiv.1	-	3	170	c.94A>G	c.(94-96)AAA>GAA	p.K32E	ABCB4_uc003uiw.1_Missense_Mutation_p.K32E|ABCB4_uc003uix.1_Missense_Mutation_p.K32E|ABCB4_uc003uiy.2_Missense_Mutation_p.K32E	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	32	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)																	---	---	---	---
ZNF804B	219578	broad.mit.edu	37	7	88964603	88964603	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:88964603A>G	uc011khi.1	+	4	2845	c.2307A>G	c.(2305-2307)ATA>ATG	p.I769M		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	769						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)												HNSCC(36;0.09)			---	---	---	---
FZD1	8321	broad.mit.edu	37	7	90895582	90895582	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:90895582C>G	uc003ula.2	+	1	1800	c.1387C>G	c.(1387-1389)CTG>GTG	p.L463V		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	463	Helical; Name=4; (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)															---	---	---	---
FZD1	8321	broad.mit.edu	37	7	90895892	90895892	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:90895892A>C	uc003ula.2	+	1	2110	c.1697A>C	c.(1696-1698)GAA>GCA	p.E566A		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	566	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)															---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91630524	91630524	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91630524A>G	uc003ulg.2	+	8	1518	c.1293A>G	c.(1291-1293)GAA>GAG	p.E431E	AKAP9_uc003ule.2_Silent_p.E443E|AKAP9_uc003ulf.2_Silent_p.E431E|AKAP9_uc003uli.2_Silent_p.E56E	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	443	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
CYP51A1	1595	broad.mit.edu	37	7	91747922	91747922	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91747922T>A	uc003ulm.3	-	8	1256	c.1094A>T	c.(1093-1095)GAT>GTT	p.D365V	CYP51A1_uc011khn.1_Missense_Mutation_p.D260V|CYP51A1_uc003uln.3_Missense_Mutation_p.D302V	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	359					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)													---	---	---	---
CDK6	1021	broad.mit.edu	37	7	92247394	92247394	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92247394G>A	uc011khw.1	-	7	1238	c.826C>T	c.(826-828)CTA>TTA	p.L276L	CDK6_uc010lez.2_Silent_p.L276L	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	276	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)					T	MLLT10	ALL								---	---	---	---
CDK6	1021	broad.mit.edu	37	7	92462455	92462455	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92462455C>T	uc011khw.1	-	2	595	c.183G>A	c.(181-183)GAG>GAA	p.E61E	CDK6_uc010lez.2_Silent_p.E61E	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	61	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)					T	MLLT10	ALL								---	---	---	---
SAMD9L	219285	broad.mit.edu	37	7	92760647	92760647	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92760647T>C	uc003umh.1	-	5	5854	c.4638A>G	c.(4636-4638)ATA>ATG	p.I1546M	SAMD9L_uc003umj.1_Missense_Mutation_p.I1546M|SAMD9L_uc003umi.1_Missense_Mutation_p.I1546M|SAMD9L_uc010lfb.1_Missense_Mutation_p.I1546M|SAMD9L_uc003umk.1_Missense_Mutation_p.I1546M|SAMD9L_uc010lfc.1_Missense_Mutation_p.I1546M|SAMD9L_uc010lfd.1_Missense_Mutation_p.I1546M|SAMD9L_uc011khx.1_3'UTR	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1546										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92923955	92923955	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92923955T>C	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
COL1A2	1278	broad.mit.edu	37	7	94056542	94056542	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94056542A>G	uc003ung.1	+	48	3673	c.3202A>G	c.(3202-3204)ACT>GCT	p.T1068A	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1068					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)										HNSCC(75;0.22)			---	---	---	---
CASD1	64921	broad.mit.edu	37	7	94174901	94174901	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94174901A>G	uc003uni.3	+	12	1748	c.1521A>G	c.(1519-1521)GTA>GTG	p.V507V	CASD1_uc003unj.3_Silent_p.V507V	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	507	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
PEG10	23089	broad.mit.edu	37	7	94293419	94293419	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94293419A>G	uc011kie.1	+	2	996	c.779A>G	c.(778-780)TAC>TGC	p.Y260C		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	184	Necessary for interaction with ALK1.				apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
PON2	5445	broad.mit.edu	37	7	95034793	95034793	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95034793C>T	uc003unv.2	-	9	1035	c.914G>A	c.(913-915)CGC>CAC	p.R305H	PON2_uc003unu.2_Missense_Mutation_p.R293H|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Missense_Mutation_p.R218H	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	305					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)															---	---	---	---
DYNC1I1	1780	broad.mit.edu	37	7	95665019	95665019	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95665019T>C	uc003uoc.3	+	13	1647	c.1370T>C	c.(1369-1371)GTT>GCT	p.V457A	DYNC1I1_uc003uod.3_Missense_Mutation_p.V440A|DYNC1I1_uc003uob.2_Missense_Mutation_p.V420A|DYNC1I1_uc003uoe.3_Missense_Mutation_p.V437A|DYNC1I1_uc010lfl.2_Missense_Mutation_p.V446A	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	457	WD 4.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)															---	---	---	---
SLC25A13	10165	broad.mit.edu	37	7	95750584	95750584	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95750584C>A	uc003uof.3	-	18	2138	c.1947G>T	c.(1945-1947)GGG>GGT	p.G649G	SLC25A13_uc003uog.3_Silent_p.G650G|SLC25A13_uc011kik.1_Silent_p.G541G	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	649					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)													---	---	---	---
LMTK2	22853	broad.mit.edu	37	7	97821801	97821801	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97821801A>G	uc003upd.1	+	11	2317	c.2024A>G	c.(2023-2025)AAC>AGC	p.N675S		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	675					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)																	---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98506451	98506451	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98506451A>G	uc003upp.2	+	14	1425	c.1216A>G	c.(1216-1218)ATC>GTC	p.I406V	TRRAP_uc011kis.1_Missense_Mutation_p.I406V|TRRAP_uc003upr.2_Missense_Mutation_p.I98V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	406					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
PDAP1	11333	broad.mit.edu	37	7	99002549	99002549	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99002549G>A	uc003uqe.2	-	2	162	c.41C>T	c.(40-42)GCG>GTG	p.A14V		NM_014891	NP_055706	Q13442	HAP28_HUMAN	PDGFA associated protein 1	14					cell proliferation|signal transduction						0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)													---	---	---	---
ZNF789	285989	broad.mit.edu	37	7	99084556	99084556	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99084556G>A	uc003uqq.1	+	5	942	c.723G>A	c.(721-723)CGG>CGA	p.R241R	ZNF789_uc010lfw.1_Silent_p.R146R|ZNF789_uc003uqr.1_Silent_p.R183R	NM_213603	NP_998768	Q5FWF6	ZN789_HUMAN	zinc finger protein 789 isoform 1	241	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
ZNF394	84124	broad.mit.edu	37	7	99091161	99091161	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99091161T>C	uc003uqs.2	-	3	1838	c.1677A>G	c.(1675-1677)TCA>TCG	p.S559S	ZNF394_uc003uqt.2_Silent_p.S352S	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	559					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)																	---	---	---	---
CYP3A43	64816	broad.mit.edu	37	7	99441821	99441821	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99441821A>G	uc003urx.1	+	4	377	c.274A>G	c.(274-276)ACA>GCA	p.T92A	CYP3A43_uc003ury.1_Missense_Mutation_p.T92A|CYP3A43_uc003urz.1_Missense_Mutation_p.T92A|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Intron	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	92			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)													---	---	---	---
TAF6	6878	broad.mit.edu	37	7	99707849	99707849	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99707849C>T	uc003uti.2	-	11	1213	c.1132G>A	c.(1132-1134)GCA>ACA	p.A378T	AP4M1_uc003utd.2_3'UTR|TAF6_uc003utg.2_Missense_Mutation_p.A300T|TAF6_uc003uth.2_Missense_Mutation_p.A435T|TAF6_uc003utk.2_Missense_Mutation_p.A378T|TAF6_uc011kji.1_Missense_Mutation_p.A415T|TAF6_uc003utj.2_Missense_Mutation_p.A368T|TAF6_uc003utl.2_Missense_Mutation_p.A378T|TAF6_uc003utm.2_Missense_Mutation_p.A378T|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	378					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
STAG3	10734	broad.mit.edu	37	7	99779803	99779803	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99779803G>A	uc003utx.1	+	3	362	c.207G>A	c.(205-207)CCG>CCA	p.P69P	STAG3_uc010lgs.1_5'UTR|STAG3_uc011kjk.1_Silent_p.P69P	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	69					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
SPDYE3	441272	broad.mit.edu	37	7	99913460	99913460	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99913460A>G	uc003uug.1	+	2	363	c.123A>G	c.(121-123)TCA>TCG	p.S41S		NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	418											0																		---	---	---	---
ZAN	7455	broad.mit.edu	37	7	100345207	100345207	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100345207A>G	uc003uwj.2	+	9	1131	c.966A>G	c.(964-966)CAA>CAG	p.Q322Q	ZAN_uc003uwk.2_Silent_p.Q322Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	322	MAM 2.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)															---	---	---	---
SLC12A9	56996	broad.mit.edu	37	7	100459368	100459368	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100459368T>C	uc003uwp.2	+	12	1688	c.1546T>C	c.(1546-1548)TAT>CAT	p.Y516H	SLC12A9_uc003uwq.2_Missense_Mutation_p.Y427H|SLC12A9_uc011kki.1_Missense_Mutation_p.Y47H|SLC12A9_uc003uwr.2_Missense_Mutation_p.Y252H|SLC12A9_uc003uws.2_Missense_Mutation_p.Y47H|SLC12A9_uc003uwt.2_Missense_Mutation_p.Y252H|SLC12A9_uc003uwv.2_Missense_Mutation_p.Y47H	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	516	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
SLC12A9	56996	broad.mit.edu	37	7	100463584	100463584	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100463584G>T	uc003uwp.2	+	14	2244	c.2102G>T	c.(2101-2103)CGG>CTG	p.R701L	SLC12A9_uc011kki.1_Missense_Mutation_p.R232L|SLC12A9_uc003uwr.2_Missense_Mutation_p.R437L|SLC12A9_uc003uws.2_Missense_Mutation_p.R232L|SLC12A9_uc003uwt.2_Missense_Mutation_p.R437L|SLC12A9_uc003uwv.2_Missense_Mutation_p.R232L|TRIP6_uc010lhk.1_5'Flank|TRIP6_uc003uww.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	701	Extracellular (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
TRIP6	7205	broad.mit.edu	37	7	100468291	100468291	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100468291A>G	uc003uww.2	+	6	1095	c.925A>G	c.(925-927)ACA>GCA	p.T309A	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	309	LIM zinc-binding 1.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
SRRT	51593	broad.mit.edu	37	7	100482368	100482368	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100482368A>G	uc003uwy.2	+	9	1218	c.950A>G	c.(949-951)AAT>AGT	p.N317S	SRRT_uc010lhl.1_Missense_Mutation_p.N317S|SRRT_uc003uxa.2_Missense_Mutation_p.N317S|SRRT_uc003uwz.2_Missense_Mutation_p.N317S	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	317	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101559512	101559512	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101559512C>T	uc003uyx.3	+						CUX1_uc003uys.3_Intron|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530			cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101925200	101925200	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101925200C>T	uc003uyt.2	+	21	1909	c.1890C>T	c.(1888-1890)TGC>TGT	p.C630C	CUX1_uc011kkn.1_Silent_p.C591C|CUX1_uc003uyw.2_Silent_p.C584C|CUX1_uc003uyv.2_Silent_p.C614C|CUX1_uc003uyu.2_Silent_p.C628C|CUX1_uc003uyz.2_RNA	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:Variant_position_missing_in_P39880_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
LRWD1	222229	broad.mit.edu	37	7	102113440	102113440	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102113440A>G	uc003uzn.2	+	15	2026	c.1888A>G	c.(1888-1890)ACC>GCC	p.T630A	LRWD1_uc003uzo.2_Missense_Mutation_p.T478A	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	630	WD 5.				chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1																		---	---	---	---
POLR2J	5439	broad.mit.edu	37	7	102114133	102114133	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102114133T>C	uc003uzp.1	-							NM_006234	NP_006225			DNA directed RNA polymerase II polypeptide J						mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|LRR domain binding|protein dimerization activity			pancreas(1)	1																		---	---	---	---
LRRC17	10234	broad.mit.edu	37	7	102574928	102574928	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102574928G>T	uc003vau.2	+	2	957	c.568G>T	c.(568-570)GCC>TCC	p.A190S	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.A190S	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	190	LRRCT 1.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1																		---	---	---	---
FBXL13	222235	broad.mit.edu	37	7	102669859	102669859	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102669859G>A	uc003vaq.2	-	3	434	c.7C>T	c.(7-9)CCG>TCG	p.P3S	FBXL13_uc010lir.1_Missense_Mutation_p.P3S|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.P3S|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	3											0																		---	---	---	---
ARMC10	83787	broad.mit.edu	37	7	102738781	102738781	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102738781C>T	uc003vaw.1	+	7	1205	c.813C>T	c.(811-813)CAC>CAT	p.H271H	ARMC10_uc003vay.1_Silent_p.H212H|ARMC10_uc003vax.1_Silent_p.H236H|ARMC10_uc003vbb.1_Silent_p.H177H|ARMC10_uc011kli.1_Silent_p.H212H|ARMC10_uc010lis.1_Silent_p.H153H|ARMC10_uc003vba.1_RNA|ARMC10_uc003vaz.1_Silent_p.H149H	NM_031905	NP_114111	Q8N2F6	ARM10_HUMAN	SVH protein isoform a	271					regulation of growth	endoplasmic reticulum membrane|integral to membrane	binding	p.H271Y(1)		ovary(1)	1																		---	---	---	---
DNAJC2	27000	broad.mit.edu	37	7	102963071	102963071	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102963071A>G	uc003vbo.2	-	9	1071	c.820T>C	c.(820-822)TAC>CAC	p.Y274H	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_5'UTR|DNAJC2_uc010lix.2_Missense_Mutation_p.Y274H|DNAJC2_uc003vbp.2_5'UTR	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	274					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103029793	103029793	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103029793T>C	uc003vbz.2	-	13	1626	c.1390A>G	c.(1390-1392)ACC>GCC	p.T464A	SLC26A5_uc003vbt.1_Missense_Mutation_p.T464A|SLC26A5_uc003vbu.1_Missense_Mutation_p.T464A|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Intron|SLC26A5_uc003vby.2_Intron|SLC26A5_uc010liy.2_Intron	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	464	Extracellular (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103033447	103033447	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103033447T>C	uc003vbz.2	-	10	1274	c.1038A>G	c.(1036-1038)ATA>ATG	p.I346M	SLC26A5_uc003vbt.1_Missense_Mutation_p.I346M|SLC26A5_uc003vbu.1_Missense_Mutation_p.I346M|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_Intron|SLC26A5_uc003vbx.2_Missense_Mutation_p.I346M|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	346	Helical; Name=8; (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
RELN	5649	broad.mit.edu	37	7	103179513	103179513	+	Intron	SNP	C	T	T	rs142041722	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103179513C>T	uc003vca.2	-						RELN_uc010liz.2_Intron	NM_005045	NP_005036			reelin isoform a						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)														---	---	---	---
RELN	5649	broad.mit.edu	37	7	103179593	103179593	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103179593G>A	uc003vca.2	-	45	7272	c.7112C>T	c.(7111-7113)GCC>GTC	p.A2371V	RELN_uc010liz.2_Missense_Mutation_p.A2371V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2371					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)														---	---	---	---
MLL5	55904	broad.mit.edu	37	7	104707256	104707256	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104707256T>C	uc003vcm.2	+	6	1031	c.497_splice	c.e6+2	p.R166_splice	MLL5_uc010lja.1_Splice_Site_p.R20_splice|MLL5_uc010ljb.1_Splice_Site_p.R166_splice|MLL5_uc003vcl.2_Splice_Site_p.R166_splice|MLL5_uc010ljc.2_Splice_Site_p.R166_splice	NM_182931	NP_891847			myeloid/lymphoid or mixed-lineage leukemia 5						cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
SRPK2	6733	broad.mit.edu	37	7	104773245	104773245	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104773245G>A	uc003vct.2	-	12	1899	c.1712C>T	c.(1711-1713)GCG>GTG	p.A571V	SRPK2_uc003vcu.2_Missense_Mutation_p.A571V|SRPK2_uc003vcv.2_Missense_Mutation_p.A582V|SRPK2_uc003vcs.1_RNA	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	571	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
SRPK2	6733	broad.mit.edu	37	7	104782498	104782498	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:104782498T>C	uc003vct.2	-	10	1654	c.1467A>G	c.(1465-1467)AGA>AGG	p.R489R	SRPK2_uc003vcu.2_Silent_p.R489R|SRPK2_uc003vcv.2_Silent_p.R500R|SRPK2_uc003vcw.1_Silent_p.R489R	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	489	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
PUS7	54517	broad.mit.edu	37	7	105111264	105111264	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105111264T>G	uc003vcx.2	-	11	1488	c.1269A>C	c.(1267-1269)GAA>GAC	p.E423D	PUS7_uc010lji.2_Missense_Mutation_p.E429D|PUS7_uc003vcy.2_Missense_Mutation_p.E423D|PUS7_uc003vcz.1_Missense_Mutation_p.E423D	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	423	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1																		---	---	---	---
PIK3CG	5294	broad.mit.edu	37	7	106508581	106508581	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:106508581A>G	uc003vdv.3	+	2	660	c.575A>G	c.(574-576)GAC>GGC	p.D192G	PIK3CG_uc003vdu.2_Missense_Mutation_p.D192G|PIK3CG_uc003vdw.2_Missense_Mutation_p.D192G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	192					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38																		---	---	---	---
SLC26A4	5172	broad.mit.edu	37	7	107334918	107334918	+	Missense_Mutation	SNP	T	C	C	rs111033307		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107334918T>C	uc003vep.2	+	11	1558	c.1334T>C	c.(1333-1335)TTG>TCG	p.L445S	SLC26A4_uc011kmb.1_Missense_Mutation_p.L32S|SLC26A4_uc011kmc.1_Intron|SLC26A4_uc011kmd.1_Missense_Mutation_p.L14S	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	445	Cytoplasmic (Potential).		L -> W (in PDS and DFNB4).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7														Pendred_syndrome				---	---	---	---
NRCAM	4897	broad.mit.edu	37	7	107808754	107808754	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107808754A>G	uc003vfb.2	-	29	3752	c.3281T>C	c.(3280-3282)GTG>GCG	p.V1094A	NRCAM_uc003vfc.2_Intron|NRCAM_uc011kmk.1_Intron|NRCAM_uc003vfd.2_Intron|NRCAM_uc003vfe.2_Intron|NRCAM_uc011kmj.1_Intron	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	1094	Fibronectin type-III 5.|Extracellular (Potential).			HV -> YA (in Ref. 8; CAA04507).	angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5																		---	---	---	---
DNAJB9	4189	broad.mit.edu	37	7	108212350	108212350	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:108212350C>T	uc003vfn.2	+	2	382	c.180C>T	c.(178-180)AGC>AGT	p.S60S	THAP5_uc003vfl.2_5'Flank|THAP5_uc003vfm.2_5'Flank	NM_012328	NP_036460	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	60	J.				ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding				0																		---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111381280	111381280	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111381280G>A	uc003vfx.2	-						DOCK4_uc011kml.1_Intron|DOCK4_uc011kmm.1_Intron|DOCK4_uc003vfw.2_Intron|DOCK4_uc003vfy.2_Intron|DOCK4_uc003vfv.2_5'Flank	NM_014705	NP_055520			dedicator of cytokinesis 4						cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111512518	111512518	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111512518T>C	uc003vfx.2	-						DOCK4_uc003vfw.2_Intron|DOCK4_uc003vfy.2_Intron|DOCK4_uc003vga.1_Intron	NM_014705	NP_055520			dedicator of cytokinesis 4						cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
ZNF277	11179	broad.mit.edu	37	7	111981052	111981052	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111981052A>G	uc003vge.2	+	11	1264	c.1135A>G	c.(1135-1137)ACT>GCT	p.T379A	ZNF277_uc003vgf.2_Missense_Mutation_p.T301A|ZNF277_uc003vgg.2_Missense_Mutation_p.T204A	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	379	C2H2-type 2.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4																		---	---	---	---
TMEM168	64418	broad.mit.edu	37	7	112423920	112423920	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112423920T>C	uc003vgn.2	-	2	1353	c.961A>G	c.(961-963)ACC>GCC	p.T321A	TMEM168_uc010lju.2_Missense_Mutation_p.T321A|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	321						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
FOXP2	93986	broad.mit.edu	37	7	114270053	114270053	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:114270053C>T	uc003vhb.2	+	5	964	c.590C>T	c.(589-591)GCG>GTG	p.A197V	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.A222V|FOXP2_uc003vha.2_Missense_Mutation_p.A105V|FOXP2_uc011kmu.1_Missense_Mutation_p.A214V|FOXP2_uc011kmv.1_Missense_Mutation_p.A197V|FOXP2_uc010ljz.1_Missense_Mutation_p.A105V|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Missense_Mutation_p.A197V|FOXP2_uc003vgx.2_Missense_Mutation_p.A197V|FOXP2_uc003vhd.2_Missense_Mutation_p.A197V|FOXP2_uc003vhc.2_Missense_Mutation_p.A222V	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	197	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8																		---	---	---	---
ING3	54556	broad.mit.edu	37	7	120593419	120593419	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120593419A>G	uc003vjn.2	+	3	296	c.162A>G	c.(160-162)AAA>AAG	p.K54K	ING3_uc011knr.1_Silent_p.K54K|ING3_uc003vjl.2_Silent_p.K54K|ING3_uc003vjm.1_Silent_p.K54K|ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Silent_p.K54K|ING3_uc011kns.1_Silent_p.K39K	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	54					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)																	---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121650430	121650430	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121650430A>G	uc003vjy.2	+	12	1725	c.1330A>G	c.(1330-1332)AAT>GAT	p.N444D	PTPRZ1_uc003vjz.2_Missense_Mutation_p.N444D|PTPRZ1_uc011knt.1_5'UTR	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	444	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
AASS	10157	broad.mit.edu	37	7	121753238	121753238	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121753238C>T	uc003vka.2	-	10	1308	c.1212G>A	c.(1210-1212)CCG>CCA	p.P404P	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.P404P|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	404	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
FEZF1	389549	broad.mit.edu	37	7	121944256	121944256	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121944256G>T	uc003vkd.2	-	1	310	c.236C>A	c.(235-237)CCT>CAT	p.P79H	FEZF1_uc003vkc.2_Missense_Mutation_p.P79H|uc010lko.1_RNA|uc003vkf.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	79					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3																		---	---	---	---
IQUB	154865	broad.mit.edu	37	7	123109382	123109382	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123109382C>T	uc003vkn.2	-	9	2044	c.1467G>A	c.(1465-1467)ACG>ACA	p.T489T	IQUB_uc003vko.2_Silent_p.T489T|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Silent_p.T489T	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	489										ovary(3)|large_intestine(1)	4																		---	---	---	---
ASB15	142685	broad.mit.edu	37	7	123256454	123256454	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123256454A>G	uc003vku.1	+	6	489	c.197A>G	c.(196-198)AAA>AGA	p.K66R	ASB15_uc003vkv.1_Missense_Mutation_p.K66R|ASB15_uc003vkw.1_Missense_Mutation_p.K66R	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	66					intracellular signal transduction					skin(2)|lung(1)	3																		---	---	---	---
SPAM1	6677	broad.mit.edu	37	7	123594255	123594255	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123594255C>T	uc003vld.2	+	4	1033	c.631C>T	c.(631-633)CGG>TGG	p.R211W	SPAM1_uc003vle.2_Missense_Mutation_p.R211W|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.R211W|SPAM1_uc010lku.2_Missense_Mutation_p.R211W	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	211				R->G: Reduces activity by over 90%.	binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)													---	---	---	---
SPAM1	6677	broad.mit.edu	37	7	123594523	123594523	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123594523T>C	uc003vld.2	+	4	1301	c.899T>C	c.(898-900)GTT>GCT	p.V300A	SPAM1_uc003vle.2_Missense_Mutation_p.V300A|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.V300A|SPAM1_uc010lku.2_Missense_Mutation_p.V300A	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	300					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)													---	---	---	---
POT1	25913	broad.mit.edu	37	7	124511107	124511107	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:124511107A>G	uc003vlm.2	-						POT1_uc011koe.1_Intron|POT1_uc003vlk.2_Intron|POT1_uc003vll.2_Intron|POT1_uc003vlo.2_Intron|POT1_uc003vln.2_Intron	NM_015450	NP_056265			protection of telomeres 1 isoform 1						DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1																		---	---	---	---
GRM8	2918	broad.mit.edu	37	7	126409971	126409971	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:126409971A>G	uc003vlr.2	-	6	1616	c.1305T>C	c.(1303-1305)AGT>AGC	p.S435S	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.S435S|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Silent_p.S156S	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	435	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)										HNSCC(24;0.065)			---	---	---	---
ATP6V1F	9296	broad.mit.edu	37	7	128505435	128505435	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128505435T>C	uc003voc.1	+	2	224	c.163T>C	c.(163-165)TTT>CTT	p.F55L	KCP_uc003vob.1_Intron	NM_004231	NP_004222	Q16864	VATF_HUMAN	ATPase, H+ transporting, lysosomal 14kD, V1	55					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|membrane fraction|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATPase activity, uncoupled|hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1																		---	---	---	---
TNPO3	23534	broad.mit.edu	37	7	128655045	128655045	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128655045T>C	uc003vol.1	-	4	914	c.540A>G	c.(538-540)GTA>GTG	p.V180V	TNPO3_uc003vom.1_Silent_p.V114V|TNPO3_uc010lly.1_Silent_p.V180V|TNPO3_uc010llz.1_Silent_p.V180V	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	180					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5																		---	---	---	---
FAM40B	57464	broad.mit.edu	37	7	129098164	129098164	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129098164C>T	uc011koy.1	+	10	1187	c.1147C>T	c.(1147-1149)CGA>TGA	p.R383*	FAM40B_uc003vow.2_Nonsense_Mutation_p.R383*|FAM40B_uc011koz.1_Translation_Start_Site	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	383											0																		---	---	---	---
FAM40B	57464	broad.mit.edu	37	7	129102882	129102882	+	Splice_Site	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129102882G>T	uc011koy.1	+	14	1591	c.1551_splice	c.e14+1	p.M517_splice	FAM40B_uc003vow.2_Splice_Site_p.M517_splice|FAM40B_uc011koz.1_Splice_Site_p.M9_splice	NM_020704	NP_065755			hypothetical protein LOC57464 isoform a												0																		---	---	---	---
MEST	4232	broad.mit.edu	37	7	130138019	130138019	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130138019G>A	uc003vqg.2	+	5	596	c.379G>A	c.(379-381)GTG>ATG	p.V127M	MEST_uc003vqc.2_Missense_Mutation_p.V118M|MEST_uc003vqd.2_Missense_Mutation_p.V118M|MEST_uc003vqf.2_Missense_Mutation_p.V118M|MEST_uc011kph.1_Missense_Mutation_p.V113M|MEST_uc010lmg.2_Missense_Mutation_p.V127M	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	127					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)																	---	---	---	---
PLXNA4	91584	broad.mit.edu	37	7	131982902	131982902	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:131982902T>C	uc003vra.3	-	4	1680	c.1451A>G	c.(1450-1452)GAT>GGT	p.D484G		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	484	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1																		---	---	---	---
LRGUK	136332	broad.mit.edu	37	7	133859333	133859333	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:133859333A>G	uc003vrm.1	+	8	981	c.965A>G	c.(964-966)TAC>TGC	p.Y322C		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	322	LRR 9.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5																		---	---	---	---
PTN	5764	broad.mit.edu	37	7	136938333	136938333	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:136938333A>G	uc003vtq.2	-	3	530	c.167T>C	c.(166-168)GTG>GCG	p.V56A	PTN_uc010lmx.2_Missense_Mutation_p.V56A|PTN_uc003vtr.1_Missense_Mutation_p.V56A	NM_002825	NP_002816	P21246	PTN_HUMAN	pleiotrophin	56					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			upper_aerodigestive_tract(1)|pancreas(1)	2																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137154289	137154289	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137154289A>G	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
KIAA1549	57670	broad.mit.edu	37	7	138601633	138601633	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138601633A>G	uc011kql.1	-	2	2788	c.2739T>C	c.(2737-2739)AGT>AGC	p.S913S	KIAA1549_uc003vuk.3_Silent_p.S863S|KIAA1549_uc011kqj.1_Silent_p.S913S	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	913						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230								O	BRAF	pilocytic astrocytoma								---	---	---	---
HIPK2	28996	broad.mit.edu	37	7	139315945	139315945	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139315945T>C	uc003vvf.3	-	4	1487	c.1313A>G	c.(1312-1314)GAC>GGC	p.D438G	HIPK2_uc003vvd.3_Missense_Mutation_p.D438G	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	438	Protein kinase.|Interaction with DAXX.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)																	---	---	---	---
BRAF	673	broad.mit.edu	37	7	140434564	140434564	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140434564C>T	uc003vwc.3	-	18	2195	c.2134G>A	c.(2134-2136)GCC>ACC	p.A712T		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	712	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
BRAF	673	broad.mit.edu	37	7	140534520	140534520	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140534520T>C	uc003vwc.3	-	3	454	c.393A>G	c.(391-393)CTA>CTG	p.L131L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	131					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				---	---	---	---
SSBP1	6742	broad.mit.edu	37	7	141443490	141443490	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141443490T>C	uc003vwo.1	+	4	293	c.215T>C	c.(214-216)GTT>GCT	p.V72A	SSBP1_uc011kri.1_Missense_Mutation_p.V72A|SSBP1_uc010lnp.1_Missense_Mutation_p.V72A	NM_003143	NP_003134	Q04837	SSBP_HUMAN	single-stranded DNA binding protein 1 precursor	72	SSB.				DNA replication|positive regulation of helicase activity	mitochondrial nucleoid	single-stranded DNA binding			ovary(1)	1	Melanoma(164;0.0171)																	---	---	---	---
MGAM	8972	broad.mit.edu	37	7	141731569	141731569	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141731569A>G	uc003vwy.2	+	13	1614	c.1560A>G	c.(1558-1560)CAA>CAG	p.Q520Q		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	520	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)													---	---	---	---
TRYX3	136541	broad.mit.edu	37	7	141952285	141952285	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141952285A>G	uc003vxb.2	-						TRYX3_uc003vxc.3_Intron	NM_001001317	NP_001001317			trypsin X3 precursor						proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	142448734	142448734	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142448734G>A	uc011krr.1	+						uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc011ksl.1_Missense_Mutation_p.V110I					SubName: Full=V_segment translation product; Flags: Fragment;																														---	---	---	---
PRSS1	5644	broad.mit.edu	37	7	142460323	142460323	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142460323C>T	uc003wak.2	+	4	513	c.496C>T	c.(496-498)CTG>TTG	p.L166L	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Silent_p.L106L	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	166	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)											Hereditary_Pancreatitis				---	---	---	---
TRPV6	55503	broad.mit.edu	37	7	142574268	142574268	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142574268A>G	uc003wbx.1	-	6	871	c.655T>C	c.(655-657)TTG>CTG	p.L219L	TRPV6_uc003wbw.1_Silent_p.L5L|TRPV6_uc010lou.1_Silent_p.L90L	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	219	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)																	---	---	---	---
CASP2	835	broad.mit.edu	37	7	142989724	142989724	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142989724C>T	uc003wco.2	+	4	555	c.408C>T	c.(406-408)TAC>TAT	p.Y136Y	CASP2_uc003wcp.2_Intron|CASP2_uc011kta.1_Silent_p.Y20Y|CASP2_uc003wcq.2_RNA	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	136					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)																	---	---	---	---
CASP2	835	broad.mit.edu	37	7	142991808	142991808	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142991808T>C	uc003wco.2	+	6	836	c.689T>C	c.(688-690)GTC>GCC	p.V230A	CASP2_uc003wcp.2_3'UTR|CASP2_uc011kta.1_Missense_Mutation_p.V114A|CASP2_uc003wcq.2_RNA	NM_032982	NP_116764	P42575	CASP2_HUMAN	caspase 2 isoform 1 preproprotein	230					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			lung(2)|ovary(1)	3	Melanoma(164;0.059)																	---	---	---	---
EPHA1	2041	broad.mit.edu	37	7	143091895	143091895	+	Intron	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143091895T>G	uc003wcz.2	-							NM_005232	NP_005223			ephrin receptor EphA1 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)																---	---	---	---
EPHA1	2041	broad.mit.edu	37	7	143095474	143095474	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143095474C>T	uc003wcz.2	-	7	1491	c.1404G>A	c.(1402-1404)GCG>GCA	p.A468A		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	468	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)																---	---	---	---
ARHGEF5	7984	broad.mit.edu	37	7	144068315	144068315	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:144068315A>G	uc003wel.2	+	6	3711	c.3593A>G	c.(3592-3594)GAT>GGT	p.D1198G	ARHGEF5_uc003wek.2_Missense_Mutation_p.D1198G|ARHGEF5_uc003wem.2_Missense_Mutation_p.D53G	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1198	DH.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)																	---	---	---	---
C7orf33	202865	broad.mit.edu	37	7	148288118	148288118	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148288118G>A	uc003wew.2	+	1	462	c.101G>A	c.(100-102)CGC>CAC	p.R34H		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	34										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)															---	---	---	---
ZNF398	57541	broad.mit.edu	37	7	148875952	148875952	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148875952G>A	uc003wfl.2	+	6	1263	c.988G>A	c.(988-990)GGT>AGT	p.G330S	ZNF398_uc011kul.1_Missense_Mutation_p.G159S|ZNF398_uc011kum.1_Missense_Mutation_p.G335S	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	330					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)															---	---	---	---
ZNF212	7988	broad.mit.edu	37	7	148949824	148949824	+	Missense_Mutation	SNP	C	T	T	rs150585649	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148949824C>T	uc003wfp.2	+	4	665	c.569C>T	c.(568-570)GCG>GTG	p.A190V		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	190	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)															---	---	---	---
ZNF777	27153	broad.mit.edu	37	7	149148196	149148196	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149148196T>C	uc003wfv.2	-	4	1144	c.981A>G	c.(979-981)GCA>GCG	p.A327A		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	327	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
ZNF777	27153	broad.mit.edu	37	7	149152530	149152530	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149152530A>G	uc003wfv.2	-	2	747	c.584T>C	c.(583-585)GTG>GCG	p.V195A		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
ZNF746	155061	broad.mit.edu	37	7	149189961	149189961	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149189961T>C	uc003wfw.2	-	4	780	c.509A>G	c.(508-510)GAC>GGC	p.D170G	ZNF746_uc010lpi.2_Missense_Mutation_p.D170G	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	170					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
ZNF746	155061	broad.mit.edu	37	7	149191542	149191542	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149191542T>C	uc003wfw.2	-	2	348	c.77A>G	c.(76-78)GAA>GGA	p.E26G	ZNF746_uc010lpi.2_Missense_Mutation_p.E26G	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	26	Potential.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)															---	---	---	---
SSPO	23145	broad.mit.edu	37	7	149480000	149480000	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149480000C>T	uc010lpk.2	+	15	1966	c.1966C>T	c.(1966-1968)CGC>TGC	p.R656C	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	656	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)															---	---	---	---
SSPO	23145	broad.mit.edu	37	7	149522125	149522125	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149522125C>T	uc010lpk.2	+	97	13912	c.13912C>T	c.(13912-13914)CGC>TGC	p.R4638C	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_Intron|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4638	TSP type-1 23.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)															---	---	---	---
REPIN1	29803	broad.mit.edu	37	7	150069806	150069806	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150069806C>T	uc010lpq.1	+	4	1965	c.1476C>T	c.(1474-1476)TGC>TGT	p.C492C	REPIN1_uc003whd.2_Silent_p.C481C|REPIN1_uc010lpr.1_Silent_p.C549C|REPIN1_uc003whc.2_Silent_p.C492C|REPIN1_uc003whe.2_Silent_p.C492C	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	492	C2H2-type 13.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)															---	---	---	---
ZNF775	285971	broad.mit.edu	37	7	150094516	150094516	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150094516G>A	uc003whf.1	+	3	1072	c.947G>A	c.(946-948)CGC>CAC	p.R316H		NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	316	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
GIMAP8	155038	broad.mit.edu	37	7	150164279	150164279	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150164279T>C	uc003whj.2	+	2	823	c.493T>C	c.(493-495)TAC>CAC	p.Y165H		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	165						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)														---	---	---	---
ACCN3	9311	broad.mit.edu	37	7	150746479	150746479	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150746479A>G	uc003win.2	+	1	875	c.507A>G	c.(505-507)CAA>CAG	p.Q169Q	ACCN3_uc003wio.2_Silent_p.Q169Q|ACCN3_uc003wip.2_Silent_p.Q169Q|ACCN3_uc003wiq.2_RNA	NM_004769	NP_004760	Q9UHC3	ACCN3_HUMAN	amiloride-sensitive cation channel 3 isoform a	169	Extracellular (Potential).				sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
SMARCD3	6604	broad.mit.edu	37	7	150936814	150936814	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150936814A>G	uc003wjs.2	-	11	1293	c.1192T>C	c.(1192-1194)TCC>CCC	p.S398P	SMARCD3_uc003wjt.2_Missense_Mutation_p.S385P|SMARCD3_uc003wju.2_Missense_Mutation_p.S385P	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	398					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
PRKAG2	51422	broad.mit.edu	37	7	151478262	151478262	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151478262T>C	uc003wkk.2	-	3	1053	c.442A>G	c.(442-444)AGG>GGG	p.R148G	PRKAG2_uc003wkj.2_Missense_Mutation_p.R104G|PRKAG2_uc010lqe.1_RNA|PRKAG2_uc003wkm.1_Missense_Mutation_p.R148G	NM_016203	NP_057287	Q9UGJ0	AAKG2_HUMAN	AMP-activated protein kinase gamma2 subunit	148					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(1)|kidney(1)	2	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151845715	151845715	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151845715C>T	uc003wla.2	-	52	13516	c.13297G>A	c.(13297-13299)GCT>ACT	p.A4433T	MLL3_uc003wkz.2_Missense_Mutation_p.A3551T|MLL3_uc003wkx.2_Missense_Mutation_p.A591T|MLL3_uc003wky.2_Missense_Mutation_p.A1997T	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4433					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.A4433T(1)		large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151853312	151853312	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151853312G>A	uc003wla.2	-	45	12009	c.11790C>T	c.(11788-11790)GCC>GCT	p.A3930A	MLL3_uc003wkz.2_Silent_p.A3048A|MLL3_uc003wkx.2_Silent_p.A88A|MLL3_uc003wky.2_Silent_p.A1494A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3930					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151859654	151859654	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151859654T>C	uc003wla.2	-	43	11227	c.11008A>G	c.(11008-11010)AAT>GAT	p.N3670D	MLL3_uc003wkz.2_Missense_Mutation_p.N2731D|MLL3_uc003wky.2_Missense_Mutation_p.N1179D	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3670					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151866269	151866269	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151866269A>G	uc003wla.2	-	41	9736	c.9517_splice	c.e41+1	p.N3173_splice	MLL3_uc003wkz.2_Splice_Site_p.N2234_splice|MLL3_uc003wky.2_Splice_Site_p.N682_splice	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
DPP6	1804	broad.mit.edu	37	7	154263973	154263973	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154263973A>G	uc003wlk.2	+	5	728	c.599A>G	c.(598-600)TAT>TGT	p.Y200C	DPP6_uc003wli.2_Missense_Mutation_p.Y136C|DPP6_uc003wlj.2_Missense_Mutation_p.Y200C|DPP6_uc003wlm.2_Missense_Mutation_p.Y138C|DPP6_uc011kvq.1_Missense_Mutation_p.Y138C	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	200	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)															---	---	---	---
DPP6	1804	broad.mit.edu	37	7	154679440	154679440	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154679440A>G	uc003wlk.2	+	23	2429	c.2300A>G	c.(2299-2301)TAC>TGC	p.Y767C	DPP6_uc003wli.2_Missense_Mutation_p.Y703C|DPP6_uc003wlm.2_Missense_Mutation_p.Y705C|DPP6_uc011kvq.1_Missense_Mutation_p.Y660C	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	767	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)															---	---	---	---
PAXIP1	22976	broad.mit.edu	37	7	154748932	154748932	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154748932A>G	uc003wlp.2	-	14	2592	c.2549_splice	c.e14+1	p.R850_splice	PAXIP1_uc003wlq.1_Splice_Site_p.R816_splice|PAXIP1_uc011kvs.1_Splice_Site_p.R814_splice	NM_007349	NP_031375			PAX interacting protein 1						DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)														---	---	---	---
RBM33	155435	broad.mit.edu	37	7	155531064	155531064	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155531064G>A	uc010lqk.1	+	11	2072	c.1704G>A	c.(1702-1704)CCG>CCA	p.P568P	RBM33_uc011kvv.1_Silent_p.P377P	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	568	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)														---	---	---	---
RNF32	140545	broad.mit.edu	37	7	156437357	156437357	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156437357A>G	uc003wmo.2	+	3	362	c.180A>G	c.(178-180)ATA>ATG	p.I60M	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.I60M|RNF32_uc003wmp.2_Missense_Mutation_p.I60M|RNF32_uc003wmq.2_Missense_Mutation_p.I60M|RNF32_uc003wmr.2_Missense_Mutation_p.I60M|RNF32_uc003wms.2_Missense_Mutation_p.I60M|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.I60M	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	60						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)														---	---	---	---
UBE3C	9690	broad.mit.edu	37	7	157000100	157000100	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157000100T>C	uc010lqs.2	+	12	1739	c.1427T>C	c.(1426-1428)GTA>GCA	p.V476A	UBE3C_uc003wng.2_Missense_Mutation_p.V476A	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	476					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)														---	---	---	---
PTPRN2	5799	broad.mit.edu	37	7	157414139	157414139	+	Silent	SNP	G	A	A	rs77143062	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157414139G>A	uc003wno.2	-	15	2380	c.2259C>T	c.(2257-2259)TGC>TGT	p.C753C	PTPRN2_uc003wnp.2_Silent_p.C736C|PTPRN2_uc003wnq.2_Silent_p.C724C|PTPRN2_uc003wnr.2_Silent_p.C715C|PTPRN2_uc011kwa.1_Silent_p.C776C	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	753	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)														---	---	---	---
PTPRN2	5799	broad.mit.edu	37	7	157929357	157929357	+	Missense_Mutation	SNP	A	G	G	rs7456452	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:157929357A>G	uc003wno.2	-	8	1284	c.1163T>C	c.(1162-1164)CTT>CCT	p.L388P	PTPRN2_uc003wnp.2_Missense_Mutation_p.L371P|PTPRN2_uc003wnq.2_Missense_Mutation_p.L388P|PTPRN2_uc003wnr.2_Missense_Mutation_p.L350P|PTPRN2_uc011kwa.1_Missense_Mutation_p.L411P	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	388	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)														---	---	---	---
NCAPG2	54892	broad.mit.edu	37	7	158472666	158472666	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:158472666A>G	uc003wnv.1	-	11	1277	c.1132T>C	c.(1132-1134)TTT>CTT	p.F378L	NCAPG2_uc010lqu.1_Missense_Mutation_p.F170L|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Missense_Mutation_p.F378L|NCAPG2_uc011kwe.1_Missense_Mutation_p.F378L	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	378					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)														---	---	---	---
DLGAP2	9228	broad.mit.edu	37	8	1626408	1626408	+	Missense_Mutation	SNP	G	A	A	rs34274599		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1626408G>A	uc003wpl.2	+	9	2174	c.2077G>A	c.(2077-2079)GTC>ATC	p.V693I	DLGAP2_uc003wpm.2_Missense_Mutation_p.V679I	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	772					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)														---	---	---	---
ARHGEF10	9639	broad.mit.edu	37	8	1893759	1893759	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:1893759C>T	uc003wpr.2	+	27	3513	c.3335C>T	c.(3334-3336)ACG>ATG	p.T1112M	ARHGEF10_uc003wps.2_Missense_Mutation_p.T1074M|ARHGEF10_uc010lre.2_Missense_Mutation_p.T763M	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1137					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)														---	---	---	---
MYOM2	9172	broad.mit.edu	37	8	2071423	2071423	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2071423T>C	uc003wpx.3	+						MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961			myomesin 2						muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3263618	3263618	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3263618A>G	uc011kwk.1	-	15	2590	c.2200T>C	c.(2200-2202)TCC>CCC	p.S734P	CSMD1_uc011kwj.1_Missense_Mutation_p.S126P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	734	Sushi 4.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	3265725	3265725	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:3265725C>T	uc011kwk.1	-	14	2160	c.1770G>A	c.(1768-1770)ACG>ACA	p.T590T	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	590	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
MCPH1	79648	broad.mit.edu	37	8	6302320	6302320	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6302320A>G	uc003wqi.2	+	8	1145	c.1077A>G	c.(1075-1077)GTA>GTG	p.V359V	MCPH1_uc003wqh.2_Silent_p.V359V|MCPH1_uc011kwl.1_Silent_p.V311V	NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	359						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)														---	---	---	---
ANGPT2	285	broad.mit.edu	37	8	6360765	6360765	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6360765A>G	uc003wqj.3	-	9	1677	c.1348T>C	c.(1348-1350)TGT>CGT	p.C450R	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.C449R|ANGPT2_uc010lri.2_Missense_Mutation_p.C398R	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	450	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)														---	---	---	---
SGK223	157285	broad.mit.edu	37	8	8235521	8235521	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8235521A>G	uc003wsh.3	-	2	398	c.398T>C	c.(397-399)CTG>CCG	p.L133P		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	133							ATP binding|non-membrane spanning protein tyrosine kinase activity				0																		---	---	---	---
CLDN23	137075	broad.mit.edu	37	8	8560303	8560303	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8560303T>G	uc003wsi.2	+	1	638	c.395T>G	c.(394-396)GTG>GGG	p.V132G		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	132	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)														---	---	---	---
PPP1R3B	79660	broad.mit.edu	37	8	8998516	8998516	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:8998516A>G	uc003wsn.3	-	2	811	c.646T>C	c.(646-648)TGC>CGC	p.C216R	PPP1R3B_uc003wso.3_Missense_Mutation_p.C215R	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	216	CBM21.				glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)														---	---	---	---
TNKS	8658	broad.mit.edu	37	8	9609199	9609199	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:9609199A>G	uc003wss.2	+	19	2918	c.2913A>G	c.(2911-2913)GTA>GTG	p.V971V	TNKS_uc011kww.1_Silent_p.V734V|TNKS_uc010lrt.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	971					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)														---	---	---	---
TNKS	8658	broad.mit.edu	37	8	9623891	9623891	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:9623891A>G	uc003wss.2	+	25	3701	c.3696A>G	c.(3694-3696)ACA>ACG	p.T1232T	TNKS_uc011kww.1_Silent_p.T995T	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1232	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)														---	---	---	---
RP1L1	94137	broad.mit.edu	37	8	10469723	10469723	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10469723A>G	uc003wtc.2	-	4	2114	c.1885T>C	c.(1885-1887)TCC>CCC	p.S629P		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	629					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)														---	---	---	---
PINX1	54984	broad.mit.edu	37	8	10677706	10677706	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10677706G>A	uc003wth.2	-	6	501	c.468C>T	c.(466-468)CCC>CCT	p.P156P	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_Intron	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	156					mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)														---	---	---	---
BLK	640	broad.mit.edu	37	8	11405571	11405571	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11405571A>G	uc003wty.2	+	4	787	c.206A>G	c.(205-207)TAC>TGC	p.Y69C	BLK_uc003wtz.2_5'UTR	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	69	SH3.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)														---	---	---	---
BLK	640	broad.mit.edu	37	8	11420560	11420560	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11420560T>C	uc003wty.2	+	12	1834	c.1253T>C	c.(1252-1254)GTG>GCG	p.V418A	BLK_uc003wtz.2_Missense_Mutation_p.V347A|BLK_uc003wua.2_Missense_Mutation_p.V254A	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	418	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)														---	---	---	---
USP17L2	377630	broad.mit.edu	37	8	11995092	11995092	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:11995092G>A	uc003wvc.1	-	1	1178	c.1178C>T	c.(1177-1179)GCC>GTC	p.A393V	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	393					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
DLC1	10395	broad.mit.edu	37	8	12957275	12957275	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:12957275G>A	uc003wwm.2	-	9	3015	c.2571C>T	c.(2569-2571)AGC>AGT	p.S857S	DLC1_uc003wwk.1_Silent_p.S420S|DLC1_uc003wwl.1_Silent_p.S454S|DLC1_uc011kxx.1_Silent_p.S346S	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	857					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7																		---	---	---	---
EFHA2	286097	broad.mit.edu	37	8	16974118	16974118	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:16974118A>G	uc003wxd.2	+							NM_181723	NP_859074			EF-hand domain family, member A2							integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)														---	---	---	---
VPS37A	137492	broad.mit.edu	37	8	17125756	17125756	+	Intron	SNP	A	G	G	rs145800895	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17125756A>G	uc003wxj.2	+						VPS37A_uc003wxk.2_Intron	NM_152415	NP_689628			hepatocellular carcinoma related protein 1						cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus					0				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)														---	---	---	---
SLC7A2	6542	broad.mit.edu	37	8	17407891	17407891	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17407891T>C	uc011kyc.1	+	5	949	c.780T>C	c.(778-780)GGT>GGC	p.G260G	SLC7A2_uc011kyd.1_Silent_p.G300G|SLC7A2_uc011kye.1_Silent_p.G300G|SLC7A2_uc011kyf.1_Silent_p.G260G	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	260	Helical; (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)													---	---	---	---
PDGFRL	5157	broad.mit.edu	37	8	17446966	17446966	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17446966A>G	uc003wxr.2	+							NM_006207	NP_006198			platelet-derived growth factor receptor-like							extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity				0				Colorectal(111;0.0752)														---	---	---	---
ASAH1	427	broad.mit.edu	37	8	17915037	17915037	+	3'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17915037G>A	uc003wyl.2	-	14					ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_3'UTR|ASAH1_uc003wyn.2_3'UTR|ASAH1_uc003wyo.2_3'UTR	NM_177924	NP_808592			N-acylsphingosine amidohydrolase 1 isoform a						ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21856749	21856749	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21856749A>G	uc003xaa.3	+	23	2678	c.2576A>G	c.(2575-2577)GAT>GGT	p.D859G	XPO7_uc010lti.2_Missense_Mutation_p.D868G|XPO7_uc010ltk.2_Missense_Mutation_p.D860G	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	859					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
XPO7	23039	broad.mit.edu	37	8	21857143	21857143	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21857143A>G	uc003xaa.3	+	24	2842	c.2740A>G	c.(2740-2742)ATG>GTG	p.M914V	XPO7_uc010lti.2_Missense_Mutation_p.M923V|XPO7_uc010ltk.2_Missense_Mutation_p.M915V	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	914					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)														---	---	---	---
FAM160B2	64760	broad.mit.edu	37	8	21956814	21956814	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:21956814C>T	uc011kyx.1	+	9	1145	c.1094C>T	c.(1093-1095)GCG>GTG	p.A365V	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	365											0																		---	---	---	---
TNFRSF10B	8795	broad.mit.edu	37	8	22900649	22900649	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22900649A>G	uc003xcu.2	-	2	543	c.250_splice	c.e2+1	p.G84_splice	TNFRSF10B_uc003xct.2_Splice_Site_p.G84_splice|TNFRSF10B_uc011kzq.1_Intron|TNFRSF10B_uc003xcv.2_Splice_Site	NM_003842	NP_003833			tumor necrosis factor receptor superfamily,						activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)														---	---	---	---
CHMP7	91782	broad.mit.edu	37	8	23112844	23112844	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23112844C>A	uc003xdc.2	+	4	1204	c.556C>A	c.(556-558)CTC>ATC	p.L186I	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Missense_Mutation_p.L76I|CHMP7_uc003xde.2_Missense_Mutation_p.L44I	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	186					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)														---	---	---	---
LOXL2	4017	broad.mit.edu	37	8	23174508	23174508	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23174508G>A	uc003xdh.1	-	9	1929	c.1590C>T	c.(1588-1590)TGC>TGT	p.C530C	LOXL2_uc010lty.1_Silent_p.C69C	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	530	SRCR 4.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)														---	---	---	---
KCTD9	54793	broad.mit.edu	37	8	25287452	25287452	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25287452T>C	uc003xeo.2	-	12	1249	c.1091A>G	c.(1090-1092)AAC>AGC	p.N364S	PPP2R2A_uc003xek.2_Intron|KCTD9_uc011lad.1_RNA	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	364	Pentapeptide repeat 3.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)														---	---	---	---
CDCA2	157313	broad.mit.edu	37	8	25361069	25361069	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25361069A>G	uc003xep.1	+						PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Missense_Mutation_p.T618A|CDCA2_uc003xeq.1_Intron|CDCA2_uc003xer.1_Intron	NM_152562	NP_689775			cell division cycle associated 2						cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)														---	---	---	---
CDCA2	157313	broad.mit.edu	37	8	25364485	25364485	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25364485A>G	uc003xep.1	+	15	2782	c.2303A>G	c.(2302-2304)GAC>GGC	p.D768G	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.D753G|CDCA2_uc003xer.1_Missense_Mutation_p.D431G	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	768					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)														---	---	---	---
PTK2B	2185	broad.mit.edu	37	8	27297910	27297910	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27297910A>G	uc003xfn.1	+	26	2799	c.1991A>G	c.(1990-1992)TAC>TGC	p.Y664C	PTK2B_uc003xfo.1_Missense_Mutation_p.Y664C|PTK2B_uc003xfp.1_Missense_Mutation_p.Y664C|PTK2B_uc003xfq.1_Missense_Mutation_p.Y664C|PTK2B_uc003xfr.1_Missense_Mutation_p.Y410C	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	664	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)														---	---	---	---
EXTL3	2137	broad.mit.edu	37	8	28588840	28588840	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28588840G>A	uc003xgz.1	+	4	2842	c.2249G>A	c.(2248-2250)CGC>CAC	p.R750H		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	750	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)														---	---	---	---
KIF13B	23303	broad.mit.edu	37	8	28980934	28980934	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28980934G>A	uc003xhh.3	-	28	3487	c.3428C>T	c.(3427-3429)GCG>GTG	p.A1143V	uc003xhi.1_Intron	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1143	Potential.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)														---	---	---	---
RBPMS	11030	broad.mit.edu	37	8	30407035	30407035	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30407035G>A	uc003xic.1	+						RBPMS_uc003xid.1_Missense_Mutation_p.V183M|RBPMS_uc003xie.1_Intron|RBPMS_uc003xif.1_Intron	NM_006867	NP_006858			RNA-binding protein with multiple splicing						positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)														---	---	---	---
GSR	2936	broad.mit.edu	37	8	30560691	30560691	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30560691T>C	uc003xih.1	-	5	650	c.559A>G	c.(559-561)AGT>GGT	p.S187G		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	187					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)													---	---	---	---
TEX15	56154	broad.mit.edu	37	8	30705316	30705316	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30705316T>C	uc003xil.2	-	1	1218	c.1218A>G	c.(1216-1218)GAA>GAG	p.E406E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	406										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)														---	---	---	---
PURG	29942	broad.mit.edu	37	8	30889698	30889698	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30889698T>C	uc003xin.2	-	1	620	c.601A>G	c.(601-603)ACC>GCC	p.T201A	WRN_uc003xio.3_5'Flank|PURG_uc003xim.1_Missense_Mutation_p.T201A	NM_013357	NP_037489	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G isoform A	201	By similarity.					nucleus	DNA binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)														---	---	---	---
WRN	7486	broad.mit.edu	37	8	30977830	30977830	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30977830T>G	uc003xio.3	+	21	3308	c.2520T>G	c.(2518-2520)GGT>GGG	p.G840G	WRN_uc010lvk.2_Silent_p.G307G	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	840	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)				Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---	---
C8orf41	80185	broad.mit.edu	37	8	33369912	33369912	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:33369912G>A	uc003xjl.3	-	1	745	c.220C>T	c.(220-222)CGG>TGG	p.R74W	C8orf41_uc003xjk.3_Missense_Mutation_p.R74W|C8orf41_uc010lvv.2_Missense_Mutation_p.R74W|C8orf41_uc003xjm.3_Missense_Mutation_p.R74W|C8orf41_uc003xjn.1_Missense_Mutation_p.R74W	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	74							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)														---	---	---	---
KCNU1	157855	broad.mit.edu	37	8	36766982	36766982	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:36766982A>C	uc010lvw.2	+	21	2347	c.2260A>C	c.(2260-2262)ATT>CTT	p.I754L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	754	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)														---	---	---	---
PROSC	11212	broad.mit.edu	37	8	37635559	37635559	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37635559A>G	uc003xkh.2	+	8	842	c.765A>G	c.(763-765)AAA>AAG	p.K255K		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	255							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GPR124	25960	broad.mit.edu	37	8	37698297	37698297	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37698297G>T	uc003xkj.2	+	18	3040	c.2677G>T	c.(2677-2679)GGG>TGG	p.G893W	GPR124_uc010lvy.2_Missense_Mutation_p.G676W	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	893	Helical; Name=4; (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)															---	---	---	---
GPR124	25960	broad.mit.edu	37	8	37699017	37699017	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37699017A>G	uc003xkj.2	+	19	3524	c.3161A>G	c.(3160-3162)TAC>TGC	p.Y1054C	GPR124_uc010lvy.2_Missense_Mutation_p.Y837C	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	1054	Helical; Name=7; (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)															---	---	---	---
DDHD2	23259	broad.mit.edu	37	8	38092104	38092104	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38092104T>C	uc003xlb.2	+	3	788	c.411_splice	c.e3+2	p.E137_splice	DDHD2_uc003xla.2_Splice_Site_p.E137_splice|DDHD2_uc003xlc.2_Splice_Site_p.E137_splice|DDHD2_uc011lbl.1_Splice_Site	NM_015214	NP_056029			DDHD domain containing 2 isoform 1						lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)															---	---	---	---
LETM2	137994	broad.mit.edu	37	8	38250157	38250157	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38250157A>G	uc003xlm.1	+	3	175	c.4A>G	c.(4-6)AAG>GAG	p.K2E	LETM2_uc003xlk.2_Missense_Mutation_p.K49E|LETM2_uc011lbn.1_5'UTR|LETM2_uc003xll.1_Missense_Mutation_p.K2E|LETM2_uc003xln.1_5'UTR|LETM2_uc003xlo.1_5'UTR	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	49	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)															---	---	---	---
ADAM32	203102	broad.mit.edu	37	8	39044429	39044429	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39044429A>G	uc003xmt.3	+	11	1162	c.917A>G	c.(916-918)TAC>TGC	p.Y306C	ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	306	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)															---	---	---	---
ADAM18	8749	broad.mit.edu	37	8	39525631	39525631	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39525631C>T	uc003xni.2	+	14	1441	c.1441C>T	c.(1441-1443)CGT>TGT	p.R481C	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.R457C	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	481	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)															---	---	---	---
AGPAT6	137964	broad.mit.edu	37	8	41467407	41467407	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:41467407A>G	uc003xnz.2	+	4	1408	c.469A>G	c.(469-471)AGC>GGC	p.S157G		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	157	Helical; (Potential).				acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)															---	---	---	---
FNTA	2339	broad.mit.edu	37	8	42939922	42939922	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42939922T>C	uc003xps.2	+	8	963	c.915T>C	c.(913-915)AGT>AGC	p.S305S	FNTA_uc003xpt.2_Silent_p.S214S|FNTA_uc003xpu.2_Silent_p.S238S|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	305					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---
HGSNAT	138050	broad.mit.edu	37	8	43002198	43002198	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:43002198T>C	uc003xpx.3	+	2	274	c.226T>C	c.(226-228)TGT>CGT	p.C76R		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	104	Lumenal, vesicle (Potential).		C -> F (in MPS3C; results in a negligible amount of protein synthesis and very low enzyme activity; retained in the endoplasmic reticulum and loss of intralysosomal proteolytic cleavage).		lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48701752	48701752	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48701752T>C	uc003xqi.2	-	76	10775	c.10718A>G	c.(10717-10719)AAT>AGT	p.N3573S	PRKDC_uc003xqj.2_Missense_Mutation_p.N3573S|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3573					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48732055	48732055	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48732055T>C	uc003xqi.2	-	68	9410	c.9353A>G	c.(9352-9354)GAT>GGT	p.D3118G	PRKDC_uc003xqj.2_Missense_Mutation_p.D3118G|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3118	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48774943	48774943	+	Silent	SNP	T	C	C	rs66507466		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48774943T>C	uc003xqi.2	-	44	5967	c.5910A>G	c.(5908-5910)AAA>AAG	p.K1970K	PRKDC_uc003xqj.2_Silent_p.K1970K|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1970					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48817531	48817531	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48817531T>C	uc003xqi.2	-	26	2997	c.2940A>G	c.(2938-2940)ACA>ACG	p.T980T	PRKDC_uc003xqj.2_Silent_p.T980T|PRKDC_uc011ldh.1_Silent_p.T980T	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	980					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
PXDNL	137902	broad.mit.edu	37	8	52322005	52322005	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:52322005A>G	uc003xqu.3	-	17	2280	c.2179T>C	c.(2179-2181)TAC>CAC	p.Y727H	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	727					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)																---	---	---	---
PXDNL	137902	broad.mit.edu	37	8	52322094	52322094	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:52322094G>A	uc003xqu.3	-	17	2191	c.2090C>T	c.(2089-2091)CCG>CTG	p.P697L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	697					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)																---	---	---	---
NPBWR1	2831	broad.mit.edu	37	8	53853400	53853400	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53853400C>T	uc011ldu.1	+	1	933	c.933C>T	c.(931-933)GAC>GAT	p.D311D		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	311	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)																---	---	---	---
SOX17	64321	broad.mit.edu	37	8	55372532	55372532	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55372532T>C	uc003xsb.3	+	2	1426	c.1222T>C	c.(1222-1224)TAC>CAC	p.Y408H		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	408	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)															---	---	---	---
RP1	6101	broad.mit.edu	37	8	55534685	55534685	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:55534685C>T	uc003xsd.1	+	3	772	c.624C>T	c.(622-624)AGC>AGT	p.S208S	RP1_uc011ldy.1_Silent_p.S208S	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	208	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)															---	---	---	---
XKR4	114786	broad.mit.edu	37	8	56435964	56435964	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56435964C>T	uc003xsf.2	+	3	1163	c.1131C>T	c.(1129-1131)TGC>TGT	p.C377C		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	377	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)															---	---	---	---
XKR4	114786	broad.mit.edu	37	8	56436422	56436422	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56436422A>G	uc003xsf.2	+	3	1621	c.1589A>G	c.(1588-1590)GAC>GGC	p.D530G		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	530						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)															---	---	---	---
RPS20	6224	broad.mit.edu	37	8	56986428	56986428	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:56986428T>C	uc003xsn.2	-						RPS20_uc003xsm.2_Intron|SNORD54_uc003xso.1_RNA	NM_001023	NP_001014			ribosomal protein S20 isoform 2						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)															---	---	---	---
PENK	5179	broad.mit.edu	37	8	57353979	57353979	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:57353979C>T	uc003xsz.2	-	2	737	c.656G>A	c.(655-657)CGC>CAC	p.R219H	PENK_uc003xta.3_Missense_Mutation_p.R219H	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	219					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)															---	---	---	---
SDCBP	6386	broad.mit.edu	37	8	59490615	59490615	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59490615G>A	uc003xtn.2	+	6	576	c.426G>A	c.(424-426)CAG>CAA	p.Q142Q	SDCBP_uc003xto.2_Silent_p.Q141Q|SDCBP_uc003xtr.2_Silent_p.Q141Q|SDCBP_uc003xtp.2_Silent_p.Q136Q|SDCBP_uc003xtq.2_Silent_p.Q142Q|SDCBP_uc003xts.2_Silent_p.Q148Q|SDCBP_uc011led.1_Silent_p.Q83Q	NM_005625	NP_005616	O00560	SDCB1_HUMAN	syntenin isoform 1	142	PDZ 1.				actin cytoskeleton organization|axon guidance|positive regulation of phosphorylation|protein targeting to membrane|substrate-dependent cell migration, cell extension|synaptic transmission	cytoskeleton|cytosol|endoplasmic reticulum membrane|focal adhesion|interleukin-5 receptor complex|melanosome|nucleus	cytoskeletal adaptor activity|frizzled binding|interleukin-5 receptor binding|protein heterodimerization activity|protein N-terminus binding|syndecan binding				0		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)																---	---	---	---
NSMAF	8439	broad.mit.edu	37	8	59502099	59502099	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:59502099T>C	uc003xtt.2	-	26	2337	c.2123A>G	c.(2122-2124)GAC>GGC	p.D708G	NSMAF_uc011lee.1_Missense_Mutation_p.D739G	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	708					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61654075	61654075	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61654075T>C	uc003xue.2	+	2	561	c.84T>C	c.(82-84)GGT>GGC	p.G28G		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	28					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61742985	61742985	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61742985G>T	uc003xue.2	+	15	4104	c.3627G>T	c.(3625-3627)GAG>GAT	p.E1209D		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1209					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61743072	61743072	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61743072A>G	uc003xue.2	+	15	4191	c.3714A>G	c.(3712-3714)GTA>GTG	p.V1238V		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1238					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61765392	61765392	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61765392G>A	uc003xue.2	+	31	6585	c.6108G>A	c.(6106-6108)CCG>CCA	p.P2036P		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2036					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
ASPH	444	broad.mit.edu	37	8	62566121	62566121	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62566121G>T	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
ASPH	444	broad.mit.edu	37	8	62588830	62588830	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62588830A>G	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron|ASPH_uc011lel.1_Intron|ASPH_uc011lem.1_Intron|ASPH_uc003xur.2_Missense_Mutation_p.V139A|ASPH_uc003xus.2_3'UTR	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
ADHFE1	137872	broad.mit.edu	37	8	67357523	67357523	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67357523A>G	uc003xwb.3	+	6	458	c.424A>G	c.(424-426)ACC>GCC	p.T142A	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Missense_Mutation_p.T94A|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Missense_Mutation_p.T72A|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	142					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
MYBL1	4603	broad.mit.edu	37	8	67479108	67479108	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67479108T>C	uc003xwj.2	-						MYBL1_uc003xwl.2_Intron|MYBL1_uc003xwk.2_Intron	NM_001080416	NP_001073885			v-myb myeloblastosis viral oncogene homolog						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)															---	---	---	---
VCPIP1	80124	broad.mit.edu	37	8	67578033	67578033	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67578033C>T	uc003xwn.2	-	1	1420	c.1161G>A	c.(1159-1161)AAG>AAA	p.K387K	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	387					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)															---	---	---	---
COPS5	10987	broad.mit.edu	37	8	67970406	67970406	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67970406T>C	uc003xxe.2	-	3	750	c.419A>G	c.(418-420)CAC>CGC	p.H140R	COPS5_uc003xxd.2_Missense_Mutation_p.H76R|COPS5_uc003xxf.2_Missense_Mutation_p.H185R|COPS5_uc010lyu.1_5'Flank|COPS5_uc010lyv.1_Missense_Mutation_p.H140R	NM_006837	NP_006828	Q92905	CSN5_HUMAN	COP9 signalosome subunit 5	140	JAMM motif.|MPN.	Zinc; catalytic (By similarity).			cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
CSPP1	79848	broad.mit.edu	37	8	68007638	68007638	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68007638T>A	uc003xxi.2	+	8	757	c.726T>A	c.(724-726)ACT>ACA	p.T242T	CSPP1_uc003xxg.1_Silent_p.T234T|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Silent_p.T207T|CSPP1_uc003xxk.2_5'UTR	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	242						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68213490	68213490	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68213490C>T	uc003xxo.1	-	3	671	c.281G>A	c.(280-282)CGC>CAC	p.R94H		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	94					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
SULF1	23213	broad.mit.edu	37	8	70488282	70488282	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70488282A>G	uc010lza.1	+	6	967	c.250A>G	c.(250-252)ACA>GCA	p.T84A	SULF1_uc003xyd.2_Missense_Mutation_p.T84A|SULF1_uc003xye.2_Missense_Mutation_p.T84A|SULF1_uc003xyf.2_Missense_Mutation_p.T84A|SULF1_uc003xyg.2_Missense_Mutation_p.T84A	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	84					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)															---	---	---	---
SLCO5A1	81796	broad.mit.edu	37	8	70744455	70744455	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:70744455C>T	uc003xyl.2	-	2	1161	c.454G>A	c.(454-456)GTA>ATA	p.V152I	SLCO5A1_uc010lzb.2_Missense_Mutation_p.V152I|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.V152I|SLCO5A1_uc010lzc.2_Missense_Mutation_p.V152I	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	152	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)													OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NCOA2	10499	broad.mit.edu	37	8	71071751	71071751	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:71071751A>G	uc003xyn.1	-	10	1275	c.1113T>C	c.(1111-1113)CAT>CAC	p.H371H		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	371					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)					T	RUNXBP2	AML								---	---	---	---
MSC	9242	broad.mit.edu	37	8	72756075	72756075	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:72756075G>A	uc003xyx.1	-	1	657	c.339C>T	c.(337-339)AAC>AAT	p.N113N	uc011lff.1_Intron|uc003xyy.2_5'Flank	NM_005098	NP_005089	O60682	MUSC_HUMAN	musculin	113	Basic motif.				transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Breast(64;0.176)		Epithelial(68;0.137)|BRCA - Breast invasive adenocarcinoma(89;0.203)													OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C8orf84	157869	broad.mit.edu	37	8	73979655	73979655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:73979655C>T	uc003xzf.2	-	5	921	c.716G>A	c.(715-717)CGG>CAG	p.R239Q		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	239					immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0																		---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77764330	77764330	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77764330A>G	uc003yav.2	+	10	5425	c.5038A>G	c.(5038-5040)ACC>GCC	p.T1680A	ZFHX4_uc003yau.1_Missense_Mutation_p.T1725A|ZFHX4_uc003yaw.1_Missense_Mutation_p.T1680A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1680	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77767833	77767833	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77767833G>A	uc003yav.2	+	10	8928	c.8541G>A	c.(8539-8541)CCG>CCA	p.P2847P	ZFHX4_uc003yau.1_Silent_p.P2892P|ZFHX4_uc003yaw.1_Silent_p.P2847P	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2847						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
PEX2	5828	broad.mit.edu	37	8	77895910	77895910	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77895910G>A	uc003yax.2	-	4	963	c.505C>T	c.(505-507)CGT>TGT	p.R169C	PEX2_uc003yay.2_Missense_Mutation_p.R169C|PEX2_uc003yaz.2_Missense_Mutation_p.R169C	NM_000318	NP_000309	P28328	PEX2_HUMAN	peroxin 2	169					peroxisome organization	integral to peroxisomal membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TPD52	7163	broad.mit.edu	37	8	80963804	80963804	+	Missense_Mutation	SNP	G	A	A	rs141089311		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:80963804G>A	uc003ybr.1	-	4	786	c.464C>T	c.(463-465)TCG>TTG	p.S155L	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Missense_Mutation_p.S115L|TPD52_uc003ybt.1_Missense_Mutation_p.S115L|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	155					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)															---	---	---	---
IMPA1	3612	broad.mit.edu	37	8	82586104	82586104	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82586104A>G	uc003ych.2	-	6	556	c.429T>C	c.(427-429)GGT>GGC	p.G143G	IMPA1_uc011lfq.1_Silent_p.G202G|IMPA1_uc011lfr.1_Silent_p.G143G	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	143					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)													---	---	---	---
RALYL	138046	broad.mit.edu	37	8	85774581	85774581	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:85774581C>T	uc003ycq.3	+	7	880	c.464C>T	c.(463-465)CCG>CTG	p.P155L	RALYL_uc003ycr.3_Missense_Mutation_p.P155L|RALYL_uc003ycs.3_Missense_Mutation_p.P155L|RALYL_uc010lzy.2_Missense_Mutation_p.P144L|RALYL_uc003yct.3_Missense_Mutation_p.P168L|RALYL_uc003ycu.3_Missense_Mutation_p.P82L|RALYL_uc003ycv.3_Missense_Mutation_p.P67L	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	155							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
LRRCC1	85444	broad.mit.edu	37	8	86035830	86035830	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:86035830C>T	uc003ycw.2	+	7	1267	c.1113C>T	c.(1111-1113)AAC>AAT	p.N371N	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Silent_p.N72N|LRRCC1_uc003ycx.2_Silent_p.N278N|LRRCC1_uc003ycy.2_Silent_p.N351N	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	371					cell division|mitosis	centriole|nucleus					0																		---	---	---	---
LRRCC1	85444	broad.mit.edu	37	8	86050657	86050657	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:86050657A>G	uc003ycw.2	+	17	2941	c.2787A>G	c.(2785-2787)GAA>GAG	p.E929E	LRRCC1_uc003ycx.2_Silent_p.E836E|LRRCC1_uc003ycy.2_Silent_p.E909E	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	929					cell division|mitosis	centriole|nucleus					0																		---	---	---	---
NBN	4683	broad.mit.edu	37	8	90982768	90982768	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90982768G>A	uc003yej.1	-	7	830	c.720C>T	c.(718-720)TCC>TCT	p.S240S	NBN_uc003yei.1_Silent_p.S158S|NBN_uc011lgb.1_Silent_p.S240S	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	240					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)										Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				---	---	---	---
NBN	4683	broad.mit.edu	37	8	90990516	90990516	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90990516T>C	uc003yej.1	-	5	626	c.516A>G	c.(514-516)GTA>GTG	p.V172V	NBN_uc003yei.1_Silent_p.V90V|NBN_uc011lgb.1_Silent_p.V172V	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	172	BRCT.				cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)										Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				---	---	---	---
SLC26A7	115111	broad.mit.edu	37	8	92352788	92352788	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92352788T>C	uc003yex.2	+						SLC26A7_uc003yey.2_Intron|SLC26A7_uc003yez.2_Intron|SLC26A7_uc003yfa.2_Intron	NM_052832	NP_439897			solute carrier family 26, member 7 isoform a							basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)															---	---	---	---
SLC26A7	115111	broad.mit.edu	37	8	92406197	92406197	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92406197A>G	uc003yex.2	+	19	2143	c.1865A>G	c.(1864-1866)AAC>AGC	p.N622S	SLC26A7_uc003yey.2_RNA|SLC26A7_uc003yez.2_Missense_Mutation_p.N622S|SLC26A7_uc003yfa.2_Missense_Mutation_p.N622S	NM_052832	NP_439897	Q8TE54	S26A7_HUMAN	solute carrier family 26, member 7 isoform a	622	STAS.|Cytoplasmic (Potential).					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.00802)															---	---	---	---
RUNX1T1	862	broad.mit.edu	37	8	92972632	92972632	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:92972632A>G	uc003yfd.2	-	11	1737	c.1653T>C	c.(1651-1653)TGT>TGC	p.C551C	RUNX1T1_uc003yfc.1_Silent_p.C524C|RUNX1T1_uc003yfe.1_Silent_p.C514C|RUNX1T1_uc010mao.2_Silent_p.C524C|RUNX1T1_uc011lgi.1_Silent_p.C562C|uc010mam.2_5'Flank|RUNX1T1_uc010man.1_Silent_p.C176C|RUNX1T1_uc003yfb.1_Silent_p.C514C	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	551	MYND-type.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)															---	---	---	---
FAM92A1	137392	broad.mit.edu	37	8	94713550	94713550	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94713550C>T	uc010maq.2	+	2	228	c.125C>T	c.(124-126)GCC>GTC	p.A42V	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	42											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)															---	---	---	---
TMEM67	91147	broad.mit.edu	37	8	94793924	94793924	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94793924A>G	uc011lgk.1	+	10	1088	c.1017A>G	c.(1015-1017)ATA>ATG	p.I339M	TMEM67_uc010mat.1_Missense_Mutation_p.I254M|TMEM67_uc010maw.2_Intron|TMEM67_uc003yga.3_Missense_Mutation_p.I258M	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	339					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)															---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95143161	95143161	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95143161A>G	uc003ygh.2	-	16	2352	c.2227T>C	c.(2227-2229)TTG>CTG	p.L743L	CDH17_uc011lgo.1_Silent_p.L529L|CDH17_uc011lgp.1_Silent_p.L743L	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	743	Cadherin 7.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95161011	95161011	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95161011C>T	uc003ygh.2	-	14	2013	c.1888G>A	c.(1888-1890)GGA>AGA	p.G630R	CDH17_uc011lgo.1_Missense_Mutation_p.G416R|CDH17_uc011lgp.1_Missense_Mutation_p.G630R	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	630	Cadherin 6.|Extracellular (Potential).					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95503952	95503952	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95503952A>G	uc003ygo.1	-	22	5007	c.4994T>C	c.(4993-4995)GTG>GCG	p.V1665A	KIAA1429_uc010maz.1_Intron	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1665					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95504890	95504890	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95504890T>C	uc003ygo.1	-	21	4811	c.4798A>G	c.(4798-4800)ATA>GTA	p.I1600V	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1600					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95523695	95523695	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95523695C>T	uc003ygo.1	-	13	3121	c.3108G>A	c.(3106-3108)GCG>GCA	p.A1036A	KIAA1429_uc003ygp.2_Silent_p.A1036A|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1036					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
ESRP1	54845	broad.mit.edu	37	8	95690551	95690551	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95690551A>G	uc003ygq.3	+	13	1955	c.1772A>G	c.(1771-1773)TAC>TGC	p.Y591C	ESRP1_uc003ygr.3_Missense_Mutation_p.Y587C|ESRP1_uc003ygs.3_Missense_Mutation_p.Y587C|ESRP1_uc003ygt.3_Missense_Mutation_p.Y591C|ESRP1_uc003ygu.3_Missense_Mutation_p.Y587C|ESRP1_uc003ygv.2_Missense_Mutation_p.Y431C|ESRP1_uc003ygw.2_Missense_Mutation_p.Y431C	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	591					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4																		---	---	---	---
DPY19L4	286148	broad.mit.edu	37	8	95746974	95746974	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95746974A>G	uc003ygx.2	+	3	368	c.244A>G	c.(244-246)AAC>GAC	p.N82D	DPY19L4_uc003ygy.2_Missense_Mutation_p.N19D	NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	82						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)																	---	---	---	---
TP53INP1	94241	broad.mit.edu	37	8	95942825	95942825	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95942825T>C	uc003yhg.2	-	4	989	c.605A>G	c.(604-606)CAG>CGG	p.Q202R	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_3'UTR	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	202					apoptosis	PML body					0	Breast(36;8.75e-07)																	---	---	---	---
PTDSS1	9791	broad.mit.edu	37	8	97307438	97307438	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:97307438G>A	uc003yht.1	+	5	656	c.554G>A	c.(553-555)AGT>AAT	p.S185N	PTDSS1_uc003yhu.1_Missense_Mutation_p.S39N	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	185					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)													---	---	---	---
PGCP	10404	broad.mit.edu	37	8	98041636	98041636	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98041636C>T	uc003yhw.2	+	6	1133	c.967C>T	c.(967-969)CGT>TGT	p.R323C		NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	323					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)																	---	---	---	---
TSPYL5	85453	broad.mit.edu	37	8	98289418	98289418	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98289418C>T	uc003yhy.2	-	1	759	c.655G>A	c.(655-657)GCG>ACG	p.A219T		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	219					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)																	---	---	---	---
TSPYL5	85453	broad.mit.edu	37	8	98289628	98289628	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:98289628C>G	uc003yhy.2	-	1	549	c.445G>C	c.(445-447)GCC>CCC	p.A149P		NM_033512	NP_277047	Q86VY4	TSYL5_HUMAN	TSPY-like 5	149					cellular response to gamma radiation|nucleosome assembly|positive regulation of cell proliferation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|regulation of growth	nucleus	protein binding			large_intestine(1)|ovary(1)	2	Breast(36;2.56e-06)																	---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100396469	100396469	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100396469C>T	uc003yiv.2	+	20	2969	c.2858C>T	c.(2857-2859)GCA>GTA	p.A953V	VPS13B_uc003yiw.2_Missense_Mutation_p.A953V|VPS13B_uc003yiu.1_Missense_Mutation_p.A953V|VPS13B_uc003yix.1_Missense_Mutation_p.A424V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	953					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100403908	100403908	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100403908C>T	uc003yiv.2	+	21	3169	c.3058C>T	c.(3058-3060)CCT>TCT	p.P1020S	VPS13B_uc003yiw.2_Missense_Mutation_p.P1020S|VPS13B_uc003yiu.1_Missense_Mutation_p.P1020S|VPS13B_uc003yix.1_Missense_Mutation_p.P490S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1020					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100711773	100711773	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100711773T>A	uc003yiv.2	+	36	6253	c.6142T>A	c.(6142-6144)TCA>ACA	p.S2048T	VPS13B_uc003yiw.2_Missense_Mutation_p.S2023T	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2048					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100833587	100833587	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100833587A>G	uc003yiv.2	+	50	9246	c.9135A>G	c.(9133-9135)AAA>AAG	p.K3045K	VPS13B_uc003yiw.2_Silent_p.K3020K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3045					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100871606	100871606	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100871606G>A	uc003yiv.2	+	57	11128	c.11017G>A	c.(11017-11019)GAC>AAC	p.D3673N	VPS13B_uc003yiw.2_Missense_Mutation_p.D3648N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3673					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100871692	100871692	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100871692A>G	uc003yiv.2	+	57	11214	c.11103A>G	c.(11101-11103)GTA>GTG	p.V3701V	VPS13B_uc003yiw.2_Silent_p.V3676V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3701					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
PABPC1	26986	broad.mit.edu	37	8	101730110	101730110	+	Missense_Mutation	SNP	A	G	G	rs76261471	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101730110A>G	uc003yjs.1	-	3	898	c.394T>C	c.(394-396)TGT>CGT	p.C132R	PABPC1_uc011lhc.1_Missense_Mutation_p.C100R|PABPC1_uc011lhd.1_Missense_Mutation_p.C87R|PABPC1_uc003yjt.1_Missense_Mutation_p.C132R|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	132	RRM 2.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)															---	---	---	---
ZNF706	51123	broad.mit.edu	37	8	102213823	102213823	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:102213823A>G	uc003yka.2	-						ZNF706_uc003ykb.2_Intron	NM_001042510	NP_001035975			HSPC038 protein							intracellular	zinc ion binding			ovary(2)	2	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103297965	103297965	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103297965G>A	uc003ykr.1	-	39	5293	c.5260C>T	c.(5260-5262)CGG>TGG	p.R1754W	UBR5_uc003yks.1_Missense_Mutation_p.R1754W	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1754					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103312362	103312362	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103312362A>G	uc003ykr.1	-	23	3005	c.2972T>C	c.(2971-2973)ATG>ACG	p.M991T	UBR5_uc003yks.1_Missense_Mutation_p.M991T	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	991					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103338886	103338886	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103338886A>G	uc003ykr.1	-	13	1520	c.1487T>C	c.(1486-1488)GTA>GCA	p.V496A	UBR5_uc003yks.1_Missense_Mutation_p.V496A	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	496					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
FZD6	8323	broad.mit.edu	37	8	104330885	104330885	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104330885T>C	uc003ylh.2	+	3	529	c.245T>C	c.(244-246)GTA>GCA	p.V82A	FZD6_uc003yli.2_Missense_Mutation_p.V82A|FZD6_uc003ylj.2_Missense_Mutation_p.V82A|FZD6_uc011lhn.1_Missense_Mutation_p.V48A|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.V27A	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	82	FZ.|Extracellular (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)															---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	104927830	104927830	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104927830T>C	uc003yls.2	+						RIMS2_uc003ylp.2_Intron|RIMS2_uc003ylw.2_Intron|RIMS2_uc003ylq.2_Intron|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_Intron|RIMS2_uc003ylu.1_Intron|RIMS2_uc003ylv.1_Intron	NM_014677	NP_055492			regulating synaptic membrane exocytosis 2						intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
RIMS2	9699	broad.mit.edu	37	8	105263882	105263882	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105263882T>C	uc003yls.2	+	28	4179	c.3938T>C	c.(3937-3939)GTG>GCG	p.V1313A	RIMS2_uc003ylp.2_Missense_Mutation_p.V1295A|RIMS2_uc003ylq.2_Missense_Mutation_p.V1109A|RIMS2_uc003ylr.2_Missense_Mutation_p.V1134A	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1357	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)												HNSCC(12;0.0054)			---	---	---	---
LRP12	29967	broad.mit.edu	37	8	105510164	105510164	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105510164G>A	uc003yma.2	-	5	711	c.616C>T	c.(616-618)CCT>TCT	p.P206S	LRP12_uc003ymb.2_Missense_Mutation_p.P187S|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	206	Extracellular (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)															---	---	---	---
OXR1	55074	broad.mit.edu	37	8	107758085	107758085	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:107758085T>C	uc011lht.1	+	15	2583	c.2484T>C	c.(2482-2484)GGT>GGC	p.G828G	OXR1_uc003ymf.2_Silent_p.G800G|OXR1_uc011lhu.1_Silent_p.G793G|OXR1_uc010mcg.2_RNA|OXR1_uc010mch.2_Silent_p.G456G|OXR1_uc003ymk.2_Silent_p.G197G|OXR1_uc003yml.2_Silent_p.G170G	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	828	TLD.				cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)															---	---	---	---
NUDCD1	84955	broad.mit.edu	37	8	110257628	110257628	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110257628A>G	uc003ynb.3	-	9	1493	c.1382T>C	c.(1381-1383)GTT>GCT	p.V461A	NUDCD1_uc003yna.2_Missense_Mutation_p.V432A|NUDCD1_uc010mcl.2_Missense_Mutation_p.V374A	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	461										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110425663	110425663	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110425663A>G	uc003yne.2	+	21	2353	c.2249A>G	c.(2248-2250)TAC>TGC	p.Y750C		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	750	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110453524	110453524	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110453524A>G	uc003yne.2	+	34	4224	c.4120A>G	c.(4120-4122)ACA>GCA	p.T1374A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1374	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110474095	110474095	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110474095A>G	uc003yne.2	+	48	7445	c.7341A>G	c.(7339-7341)GTA>GTG	p.V2447V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2447	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
KCNV1	27012	broad.mit.edu	37	8	110980664	110980664	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110980664C>T	uc003ynr.3	-	3	1498	c.1156G>A	c.(1156-1158)GCC>ACC	p.A386T	KCNV1_uc010mcw.2_Missense_Mutation_p.A386T	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	386						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)															---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113256718	113256718	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113256718T>C	uc003ynu.2	-	65	10466	c.10307A>G	c.(10306-10308)TAT>TGT	p.Y3436C	CSMD3_uc003yns.2_Missense_Mutation_p.Y2638C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y3396C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y3267C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3436	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113293395	113293395	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113293395A>G	uc003ynu.2	-						CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Intron|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113702138	113702138	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113702138T>C	uc003ynu.2	-	14	2273	c.2114A>G	c.(2113-2115)CAA>CGA	p.Q705R	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.Q665R|CSMD3_uc011lhx.1_Missense_Mutation_p.Q601R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	705	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	114449089	114449089	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:114449089T>C	uc003ynu.2	-	1					CSMD3_uc011lhx.1_5'UTR|CSMD3_uc010mcx.1_5'UTR|CSMD3_uc003ynx.3_5'UTR	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)	OREG0018933	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116599390	116599390	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116599390C>T	uc003ynz.2	-	4	2958	c.2499G>A	c.(2497-2499)GTG>GTA	p.V833V	TRPS1_uc011lhy.1_Silent_p.V837V|TRPS1_uc003yny.2_Silent_p.V846V|TRPS1_uc010mcy.2_Silent_p.V833V	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	833					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116616290	116616290	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116616290T>C	uc003ynz.2	-	3	2326	c.1867A>G	c.(1867-1869)ACC>GCC	p.T623A	TRPS1_uc011lhy.1_Missense_Mutation_p.T627A|TRPS1_uc003yny.2_Missense_Mutation_p.T636A|TRPS1_uc010mcy.2_Missense_Mutation_p.T623A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	623	C2H2-type 3; atypical.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116617019	116617019	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116617019T>C	uc003ynz.2	-	3	1597	c.1138A>G	c.(1138-1140)AAC>GAC	p.N380D	TRPS1_uc011lhy.1_Missense_Mutation_p.N384D|TRPS1_uc003yny.2_Missense_Mutation_p.N393D|TRPS1_uc010mcy.2_Missense_Mutation_p.N380D	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	380					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
EXT1	2131	broad.mit.edu	37	8	118825188	118825188	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:118825188G>A	uc003yok.1	-	8	2418	c.1645C>T	c.(1645-1647)CGT>TGT	p.R549C		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	549	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)					Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				---	---	---	---
EXT1	2131	broad.mit.edu	37	8	118831934	118831934	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:118831934T>A	uc003yok.1	-	6	2290	c.1517A>T	c.(1516-1518)AAG>ATG	p.K506M		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	506	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)					Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120809270	120809270	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120809270C>T	uc003you.2	-	8	1321	c.1051G>A	c.(1051-1053)GCC>ACC	p.A351T		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	351					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
DEPDC6	64798	broad.mit.edu	37	8	120977536	120977536	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120977536A>G	uc003yow.3	+	4	677	c.490A>G	c.(490-492)ACC>GCC	p.T164A	DEPDC6_uc011lid.1_Missense_Mutation_p.T63A	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	164	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
DEPDC6	64798	broad.mit.edu	37	8	121061867	121061867	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121061867A>G	uc003yow.3	+	9	1341	c.1154A>G	c.(1153-1155)TAC>TGC	p.Y385C	DEPDC6_uc011lid.1_Missense_Mutation_p.Y284C	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	385	PDZ.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
COL14A1	7373	broad.mit.edu	37	8	121327827	121327827	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121327827T>C	uc003yox.2	+	39	4870	c.4605_splice	c.e39+2	p.Q1535_splice	COL14A1_uc003yoz.2_Splice_Site_p.Q500_splice	NM_021110	NP_066933			collagen, type XIV, alpha 1 precursor						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
ZHX2	22882	broad.mit.edu	37	8	123964290	123964290	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:123964290G>T	uc003ypk.1	+	3	1107	c.540G>T	c.(538-540)TCG>TCT	p.S180S		NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	180						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
WDR67	93594	broad.mit.edu	37	8	124140543	124140543	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124140543A>G	uc003ypp.1	+	14	1997	c.1907A>G	c.(1906-1908)AAC>AGC	p.N636S	WDR67_uc011lig.1_Missense_Mutation_p.N636S|WDR67_uc011lih.1_Missense_Mutation_p.N526S|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Intron|WDR67_uc003ypt.1_Missense_Mutation_p.N93S|WDR67_uc003ypu.1_Missense_Mutation_p.N93S	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	636						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
WDR67	93594	broad.mit.edu	37	8	124164129	124164129	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124164129A>G	uc003ypp.1	+	22	3241	c.3151A>G	c.(3151-3153)ACT>GCT	p.T1051A	WDR67_uc011lig.1_Missense_Mutation_p.T955A|WDR67_uc011lih.1_Missense_Mutation_p.T941A|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.T685A|WDR67_uc003ypt.1_Missense_Mutation_p.T443A|WDR67_uc003ypu.1_Missense_Mutation_p.T443A	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	1051						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
ZHX1	11244	broad.mit.edu	37	8	124267009	124267009	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124267009T>C	uc003yqe.2	-	3	1608	c.1178A>G	c.(1177-1179)CAG>CGG	p.Q393R	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.Q393R|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.Q393R	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	393	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)															---	---	---	---
ATAD2	29028	broad.mit.edu	37	8	124348743	124348743	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124348743T>C	uc003yqh.3	-	22	3189	c.3081A>G	c.(3079-3081)CAA>CAG	p.Q1027Q	ATAD2_uc011lii.1_Silent_p.Q818Q|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1027	Bromo.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
ATAD2	29028	broad.mit.edu	37	8	124382167	124382167	+	Missense_Mutation	SNP	A	T	T	rs149531312	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124382167A>T	uc003yqh.3	-	7	933	c.825T>A	c.(823-825)GAT>GAA	p.D275E	ATAD2_uc011lii.1_Missense_Mutation_p.D66E|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.D275E	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	275	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
ATAD2	29028	broad.mit.edu	37	8	124382203	124382203	+	Missense_Mutation	SNP	T	A	A	rs145837201	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124382203T>A	uc003yqh.3	-	7	897	c.789A>T	c.(787-789)GAA>GAT	p.E263D	ATAD2_uc011lii.1_Missense_Mutation_p.E54D|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Missense_Mutation_p.E263D	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	263	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
ANXA13	312	broad.mit.edu	37	8	124705988	124705988	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124705988T>C	uc003yqu.2	-	7	576	c.503A>G	c.(502-504)AAA>AGA	p.K168R	ANXA13_uc003yqt.2_Missense_Mutation_p.K209R	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	168					cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
FER1L6	654463	broad.mit.edu	37	8	125015417	125015417	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125015417A>G	uc003yqw.2	+	13	1736	c.1530A>G	c.(1528-1530)GGA>GGG	p.G510G	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	510	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)															---	---	---	---
RNF139	11236	broad.mit.edu	37	8	125498142	125498142	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125498142A>G	uc003yrc.2	+	2	595	c.252A>G	c.(250-252)TCA>TCG	p.S84S		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	84					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)											Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				---	---	---	---
TATDN1	83940	broad.mit.edu	37	8	125528239	125528239	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125528239T>C	uc003yrd.2	-	5	277	c.235A>G	c.(235-237)ACA>GCA	p.T79A	TATDN1_uc003yre.2_RNA|TATDN1_uc010mdm.2_Missense_Mutation_p.T32A|TATDN1_uc003yrf.2_Missense_Mutation_p.T79A	NM_032026	NP_114415	Q6P1N9	TATD1_HUMAN	TatD DNase domain containing 1 isoform a	79						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
KIAA0196	9897	broad.mit.edu	37	8	126087304	126087304	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126087304T>C	uc003yrt.2	-	8	1243	c.914A>G	c.(913-915)GAA>GGA	p.E305G	KIAA0196_uc011lir.1_Missense_Mutation_p.E157G	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	305					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)															---	---	---	---
ADCY8	114	broad.mit.edu	37	8	131812714	131812714	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131812714T>C	uc003ytd.3	-	15	3274	c.3018A>G	c.(3016-3018)GAA>GAG	p.E1006E	ADCY8_uc010mds.2_Silent_p.E875E	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1006	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)												HNSCC(32;0.087)			---	---	---	---
ADCY8	114	broad.mit.edu	37	8	131826480	131826480	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:131826480T>C	uc003ytd.3	-						ADCY8_uc010mds.2_Intron	NM_001115	NP_001106			adenylate cyclase 8						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)												HNSCC(32;0.087)			---	---	---	---
EFR3A	23167	broad.mit.edu	37	8	132997309	132997309	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:132997309T>C	uc003yte.2	+	16	2070	c.1869_splice	c.e16+2	p.K623_splice		NM_015137	NP_055952			EFR3 homolog A							plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)															---	---	---	---
TG	7038	broad.mit.edu	37	8	133879302	133879302	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133879302C>T	uc003ytw.2	+	1	98	c.57C>T	c.(55-57)GCC>GCT	p.A19A		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	19					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
TG	7038	broad.mit.edu	37	8	133883660	133883660	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133883660C>A	uc003ytw.2	+	4	383	c.342C>A	c.(340-342)ACC>ACA	p.T114T		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	114	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
TG	7038	broad.mit.edu	37	8	133899319	133899319	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133899319C>A	uc003ytw.2	+	9	1743	c.1702C>A	c.(1702-1704)CTT>ATT	p.L568I		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	568					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
TG	7038	broad.mit.edu	37	8	133900283	133900283	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133900283C>T	uc003ytw.2	+	10	2272	c.2231C>T	c.(2230-2232)GCC>GTC	p.A744V		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	744	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
WISP1	8840	broad.mit.edu	37	8	134225274	134225274	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134225274C>T	uc003yub.2	+	2	313	c.237C>T	c.(235-237)TGC>TGT	p.C79C	WISP1_uc003yuc.2_Silent_p.C79C|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Silent_p.C79C|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_5'Flank	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	79	IGFBP N-terminal.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
FAM135B	51059	broad.mit.edu	37	8	139164318	139164318	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139164318A>G	uc003yuy.2	-	13	2571	c.2400T>C	c.(2398-2400)GAT>GAC	p.D800D	FAM135B_uc003yux.2_Silent_p.D701D|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.D362D|FAM135B_uc003yvb.2_Silent_p.D362D	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	800										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)												HNSCC(54;0.14)			---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139628233	139628233	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139628233A>G	uc003yvd.2	-						COL22A1_uc011ljo.1_Intron	NM_152888	NP_690848			collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139890062	139890062	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139890062C>T	uc003yvd.2	-	3	1036	c.589G>A	c.(589-591)GTC>ATC	p.V197I		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	197	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
EIF2C2	27161	broad.mit.edu	37	8	141542189	141542189	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141542189G>A	uc003yvn.2	-	19	2574	c.2534C>T	c.(2533-2535)GCG>GTG	p.A845V	EIF2C2_uc010men.2_Missense_Mutation_p.A768V|EIF2C2_uc010meo.2_Missense_Mutation_p.A811V	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	845					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)															---	---	---	---
EIF2C2	27161	broad.mit.edu	37	8	141566004	141566004	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141566004G>A	uc003yvn.2	-	10	1300	c.1260C>T	c.(1258-1260)TAC>TAT	p.Y420Y	EIF2C2_uc010men.2_Silent_p.Y343Y|EIF2C2_uc010meo.2_Silent_p.Y420Y	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	420					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)															---	---	---	---
DENND3	22898	broad.mit.edu	37	8	142151331	142151331	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142151331G>A	uc003yvy.2	+	4	569	c.291G>A	c.(289-291)ACG>ACA	p.T97T	DENND3_uc003yvw.1_Silent_p.T110T|DENND3_uc003yvx.2_Missense_Mutation_p.R176H|DENND3_uc010mep.2_Silent_p.T110T	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	97										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
DENND3	22898	broad.mit.edu	37	8	142160983	142160983	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142160983C>T	uc003yvy.2	+	6	824	c.546C>T	c.(544-546)CCC>CCT	p.P182P	DENND3_uc010mep.2_Silent_p.P195P	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	182	DENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
DENND3	22898	broad.mit.edu	37	8	142200505	142200505	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142200505G>A	uc003yvy.2	+	20	3406	c.3128G>A	c.(3127-3129)CGC>CAC	p.R1043H	DENND3_uc010mep.2_Missense_Mutation_p.R1004H|DENND3_uc003ywa.1_Missense_Mutation_p.R93H|DENND3_uc003ywb.2_Missense_Mutation_p.R93H	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1043										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
SLC45A4	57210	broad.mit.edu	37	8	142228816	142228816	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142228816T>C	uc003ywd.1	-	4	1078	c.770A>G	c.(769-771)GAC>GGC	p.D257G	SLC45A4_uc003ywc.1_Missense_Mutation_p.D257G|SLC45A4_uc010meq.1_Missense_Mutation_p.D255G	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	308					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
GPR20	2843	broad.mit.edu	37	8	142367700	142367700	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142367700C>T	uc003ywf.2	-	2	413	c.324G>A	c.(322-324)ACG>ACA	p.T108T		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	108	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)															---	---	---	---
FLJ43860	389690	broad.mit.edu	37	8	142445294	142445294	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142445294T>C	uc003ywi.2	-	29	3692	c.3611A>G	c.(3610-3612)CAC>CGC	p.H1204R	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1204							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
LYNX1	66004	broad.mit.edu	37	8	143856711	143856711	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143856711G>A	uc003yxc.1	-	4	495	c.225C>T	c.(223-225)GGC>GGT	p.G75G	LYNX1_uc003yxb.2_Intron|LYNX1_uc003yxd.1_Silent_p.G75G|LYNX1_uc003yxe.1_Silent_p.G75G	NM_177476	NP_803429	Q9BZG9	LYNX1_HUMAN	Ly-6 neurotoxin-like protein 1 isoform c	75	UPAR/Ly6.					anchored to membrane|plasma membrane					0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
LY6D	8581	broad.mit.edu	37	8	143867011	143867011	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143867011T>C	uc003yxf.1	-	2	221	c.145A>G	c.(145-147)AAC>GAC	p.N49D		NM_003695	NP_003686	Q14210	LY6D_HUMAN	lymphocyte antigen 6 complex, locus D precursor	49	UPAR/Ly6.				cell adhesion	anchored to membrane|membrane fraction|plasma membrane	protein binding				0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
CYP11B2	1585	broad.mit.edu	37	8	143994741	143994741	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143994741C>T	uc003yxk.1	-	6	1084	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	361					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)									Familial_Hyperaldosteronism_type_I				---	---	---	---
PUF60	22827	broad.mit.edu	37	8	144900634	144900634	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144900634A>G	uc003yzs.2	-	6	483	c.419T>C	c.(418-420)CTG>CCG	p.L140P	PUF60_uc003yzr.2_Missense_Mutation_p.L80P|PUF60_uc003yzt.2_Missense_Mutation_p.L123P|PUF60_uc003yzq.2_Missense_Mutation_p.L97P|PUF60_uc003yzu.1_Missense_Mutation_p.L129P	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	140	RRM 1.|Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
EPPK1	83481	broad.mit.edu	37	8	144945718	144945718	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144945718T>C	uc003zaa.1	-	1	1717	c.1704A>G	c.(1702-1704)ACA>ACG	p.T568T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	568	Plectin 10.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144994121	144994121	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144994121T>C	uc003zaf.1	-	32	10449	c.10279A>G	c.(10279-10281)ACC>GCC	p.T3427A	PLEC_uc003zab.1_Missense_Mutation_p.T3290A|PLEC_uc003zac.1_Missense_Mutation_p.T3294A|PLEC_uc003zad.2_Missense_Mutation_p.T3290A|PLEC_uc003zae.1_Missense_Mutation_p.T3258A|PLEC_uc003zag.1_Missense_Mutation_p.T3268A|PLEC_uc003zah.2_Missense_Mutation_p.T3276A|PLEC_uc003zaj.2_Missense_Mutation_p.T3317A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3427	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
PLEC	5339	broad.mit.edu	37	8	145005812	145005812	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145005812G>A	uc003zaf.1	-	19	2775	c.2605C>T	c.(2605-2607)CGG>TGG	p.R869W	PLEC_uc003zab.1_Missense_Mutation_p.R732W|PLEC_uc003zac.1_Missense_Mutation_p.R736W|PLEC_uc003zad.2_Missense_Mutation_p.R732W|PLEC_uc003zae.1_Missense_Mutation_p.R700W|PLEC_uc003zag.1_Missense_Mutation_p.R710W|PLEC_uc003zah.2_Missense_Mutation_p.R718W|PLEC_uc003zaj.2_Missense_Mutation_p.R759W	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	869	Spectrin 3.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
GRINA	2907	broad.mit.edu	37	8	145066997	145066997	+	Silent	SNP	C	T	T	rs139058041	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145066997C>T	uc003zan.1	+	7	1270	c.1104C>T	c.(1102-1104)CGC>CGT	p.R368R	GRINA_uc003zao.1_Silent_p.R368R|GRINA_uc003zap.1_Silent_p.R368R	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	368						integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
GPAA1	8733	broad.mit.edu	37	8	145139749	145139749	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145139749G>A	uc003zax.2	+	8	1245	c.1135G>A	c.(1135-1137)GGC>AGC	p.G379S	GPAA1_uc003zav.1_Missense_Mutation_p.G257S|GPAA1_uc003zaw.1_Missense_Mutation_p.G319S	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	379	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
FBXL6	26233	broad.mit.edu	37	8	145579255	145579255	+	Missense_Mutation	SNP	T	C	C	rs140699050		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145579255T>C	uc003zcb.2	-	9	1581	c.1556A>G	c.(1555-1557)TAC>TGC	p.Y519C	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'UTR|FBXL6_uc003zbz.2_Missense_Mutation_p.Y246C|FBXL6_uc003zca.2_Missense_Mutation_p.Y513C|FBXL6_uc010mfx.2_Missense_Mutation_p.Y280C|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	519					proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)															---	---	---	---
CPSF1	29894	broad.mit.edu	37	8	145619366	145619366	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145619366C>T	uc003zcj.2	-	34	3896	c.3821G>A	c.(3820-3822)CGC>CAC	p.R1274H	MIR939_hsa-mir-939|MI0005761_RNA	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	1274					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)															---	---	---	---
SLC39A4	55630	broad.mit.edu	37	8	145640188	145640188	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145640188G>A	uc003zcq.2	-	5	997	c.897C>T	c.(895-897)GCC>GCT	p.A299A	SLC39A4_uc003zcm.1_5'Flank|SLC39A4_uc003zcn.2_5'Flank|SLC39A4_uc003zco.2_Silent_p.A23A|SLC39A4_uc003zcp.2_Silent_p.A274A	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	299	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)															---	---	---	---
NFKBIL2	4796	broad.mit.edu	37	8	145655794	145655794	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145655794G>A	uc011llg.1	-	25	3951	c.3936C>T	c.(3934-3936)GGC>GGT	p.G1312G	VPS28_uc003zcs.1_5'Flank|VPS28_uc003zct.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1312					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
MFSD3	113655	broad.mit.edu	37	8	145735779	145735779	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145735779T>C	uc003zdi.1	+	2	884	c.719T>C	c.(718-720)CTG>CCG	p.L240P		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	240	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)															---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145773654	145773654	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145773654C>T	uc003zdt.1	-	6	1371	c.816G>A	c.(814-816)CCG>CCA	p.P272P	ARHGAP39_uc011llk.1_Silent_p.P272P|ARHGAP39_uc003zds.1_Silent_p.P272P	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	272	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145780968	145780968	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145780968G>A	uc003zdt.1	-	5	1127	c.572C>T	c.(571-573)GCG>GTG	p.A191V	ARHGAP39_uc011llk.1_Missense_Mutation_p.A191V|ARHGAP39_uc003zds.1_Missense_Mutation_p.A191V	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	191					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
ZNF34	80778	broad.mit.edu	37	8	145999512	145999512	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145999512A>G	uc003zdy.3	-	6	924	c.822T>C	c.(820-822)ACT>ACC	p.T274T	ZNF34_uc010mgb.2_Silent_p.T171T|ZNF34_uc003zdx.3_Silent_p.T253T	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)														---	---	---	---
ZNF34	80778	broad.mit.edu	37	8	145999668	145999668	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145999668T>C	uc003zdy.3	-	6	768	c.666A>G	c.(664-666)ACA>ACG	p.T222T	ZNF34_uc010mgb.2_Silent_p.T119T|ZNF34_uc003zdx.3_Silent_p.T201T	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)														---	---	---	---
ZNF7	7553	broad.mit.edu	37	8	146054477	146054477	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146054477T>C	uc003zeg.3	+	2	140	c.3_splice	c.e2+2	p.M1_splice	ZNF7_uc010mge.2_Splice_Site_p.M1_splice|ZNF7_uc011lln.1_Splice_Site|ZNF7_uc003zeh.2_Splice_Site_p.M1_splice|ZNF7_uc003zej.2_Splice_Site_p.M1_splice	NM_003416	NP_003407			zinc finger protein 7						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)														---	---	---	---
ZNF250	58500	broad.mit.edu	37	8	146108158	146108158	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146108158T>C	uc003zeq.3	-	6	542	c.425A>G	c.(424-426)CAA>CGA	p.Q142R	COMMD5_uc010mgf.2_Intron|ZNF250_uc003zer.3_Missense_Mutation_p.Q137R|ZNF250_uc010mgg.2_Missense_Mutation_p.Q137R	NM_021061	NP_066405	P15622	ZN250_HUMAN	zinc finger protein 250 isoform a	142					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)														---	---	---	---
FOXD4	2298	broad.mit.edu	37	9	117563	117563	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117563T>C	uc003zfz.2	-	1	855	c.557A>G	c.(556-558)GAC>GGC	p.D186G		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	186	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
DOCK8	81704	broad.mit.edu	37	9	382641	382641	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:382641C>A	uc003zgf.2	+	22	2846	c.2734C>A	c.(2734-2736)CAC>AAC	p.H912N	DOCK8_uc010mgu.2_Missense_Mutation_p.H214N|DOCK8_uc010mgv.2_Missense_Mutation_p.H844N|DOCK8_uc010mgw.1_Missense_Mutation_p.H214N|DOCK8_uc003zgk.2_Missense_Mutation_p.H370N	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	912					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)														---	---	---	---
DMRT1	1761	broad.mit.edu	37	9	916875	916875	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:916875A>G	uc003zgv.2	+	4	1084	c.935A>G	c.(934-936)GAT>GGT	p.D312G		NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	312					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)														---	---	---	---
SMARCA2	6595	broad.mit.edu	37	9	2161726	2161726	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2161726T>C	uc003zhc.2	+	28	4121	c.4022T>C	c.(4021-4023)GTA>GCA	p.V1341A	SMARCA2_uc003zhd.2_Missense_Mutation_p.V1341A|SMARCA2_uc010mha.2_Missense_Mutation_p.V1274A|SMARCA2_uc011llw.1_Missense_Mutation_p.V45A|SMARCA2_uc003zhf.2_Missense_Mutation_p.V5A|SMARCA2_uc011llx.1_Missense_Mutation_p.V5A|SMARCA2_uc003zhe.2_Missense_Mutation_p.V47A|SMARCA2_uc003zhg.2_Missense_Mutation_p.V5A|SMARCA2_uc010mhb.2_Missense_Mutation_p.V29A	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1341					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)														---	---	---	---
RFX3	5991	broad.mit.edu	37	9	3262957	3262957	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:3262957C>T	uc003zhr.2	-	14	1895	c.1583G>A	c.(1582-1584)CGT>CAT	p.R528H	RFX3_uc010mhd.2_Missense_Mutation_p.R528H|RFX3_uc003zhs.1_Missense_Mutation_p.R528H	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	528					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)														---	---	---	---
GLIS3	169792	broad.mit.edu	37	9	4118618	4118618	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4118618C>T	uc003zhw.1	-	3	589	c.395G>A	c.(394-396)CGG>CAG	p.R132Q	GLIS3_uc003zhx.1_Missense_Mutation_p.R287Q|GLIS3_uc003zic.1_Missense_Mutation_p.R287Q|GLIS3_uc003zie.1_Missense_Mutation_p.R287Q|GLIS3_uc010mhh.1_Missense_Mutation_p.R162Q|GLIS3_uc003zid.1_Missense_Mutation_p.R65Q|GLIS3_uc010mhi.1_Missense_Mutation_p.R94Q|GLIS3_uc003zif.1_Missense_Mutation_p.R65Q|GLIS3_uc003zig.1_Missense_Mutation_p.R131Q|GLIS3_uc003zih.1_Missense_Mutation_p.R65Q|GLIS3_uc003zhy.1_Missense_Mutation_p.R65Q|GLIS3_uc003zhz.1_Missense_Mutation_p.R65Q|GLIS3_uc003zib.1_Missense_Mutation_p.R131Q|GLIS3_uc010mhg.1_Missense_Mutation_p.R65Q	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	132	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)														---	---	---	---
JAK2	3717	broad.mit.edu	37	9	5072632	5072632	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5072632T>C	uc010mhm.2	+						JAK2_uc003ziw.2_Intron	NM_004972	NP_004963			Janus kinase 2						actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				---	---	---	---
ERMP1	79956	broad.mit.edu	37	9	5811260	5811260	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5811260T>G	uc003zjm.1	-	7	1232	c.1178A>C	c.(1177-1179)AAG>ACG	p.K393T	ERMP1_uc011lme.1_RNA|ERMP1_uc010mhs.1_Missense_Mutation_p.K7T	NM_024896	NP_079172	Q7Z2K6	ERMP1_HUMAN	aminopeptidase Fxna	393	Extracellular (Potential).				proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)														---	---	---	---
KIAA2026	158358	broad.mit.edu	37	9	5929149	5929149	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5929149T>C	uc003zjq.3	-	6	2609	c.2393A>G	c.(2392-2394)TAT>TGT	p.Y798C	KIAA2026_uc010mht.2_5'UTR	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	798										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)														---	---	---	---
KIAA2026	158358	broad.mit.edu	37	9	5968410	5968410	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5968410T>C	uc003zjq.3	-	3	2037	c.1821A>G	c.(1819-1821)CCA>CCG	p.P607P		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	607										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)														---	---	---	---
KIAA2026	158358	broad.mit.edu	37	9	5988525	5988525	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:5988525G>A	uc003zjq.3	-	2	830	c.614C>T	c.(613-615)ACG>ATG	p.T205M		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	205										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)														---	---	---	---
RANBP6	26953	broad.mit.edu	37	9	6012876	6012876	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6012876A>G	uc003zjr.2	-	1	2743	c.2732T>C	c.(2731-2733)GTA>GCA	p.V911A	RANBP6_uc011lmf.1_Missense_Mutation_p.V559A|RANBP6_uc003zjs.2_Missense_Mutation_p.V499A	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	911	HEAT 6.				protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)														---	---	---	---
UHRF2	115426	broad.mit.edu	37	9	6486850	6486850	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6486850T>C	uc003zjy.2	+	9	1762	c.1422T>C	c.(1420-1422)CAT>CAC	p.H474H	UHRF2_uc003zjz.2_RNA|UHRF2_uc003zka.1_Silent_p.H251H|UHRF2_uc003zkb.2_RNA	NM_152896	NP_690856	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains	474	YDG.|Methyl-CpG binding and interaction with HDAC1.				cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)														---	---	---	---
GLDC	2731	broad.mit.edu	37	9	6536071	6536071	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6536071G>A	uc003zkc.2	-	23	3024	c.2831C>T	c.(2830-2832)CCG>CTG	p.P944L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	944					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
KDM4C	23081	broad.mit.edu	37	9	6984274	6984274	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6984274T>G	uc003zkh.2	+	10	1804	c.1224T>G	c.(1222-1224)GAT>GAG	p.D408E	KDM4C_uc010mhu.2_Missense_Mutation_p.D430E|KDM4C_uc011lmi.1_Missense_Mutation_p.D408E|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Missense_Mutation_p.D408E|KDM4C_uc011lmk.1_Missense_Mutation_p.D227E|KDM4C_uc011lml.1_Missense_Mutation_p.D95E	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	408					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1																		---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8500960	8500960	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8500960A>G	uc003zkk.2	-	23	2633	c.1922T>C	c.(1921-1923)ATT>ACT	p.I641T	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.I641T|PTPRD_uc003zkm.2_Missense_Mutation_p.I628T|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	641	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8518133	8518133	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8518133C>T	uc003zkk.2	-	20	1969	c.1258G>A	c.(1258-1260)GCC>ACC	p.A420T	PTPRD_uc003zkp.2_Missense_Mutation_p.A420T|PTPRD_uc003zkq.2_Missense_Mutation_p.A420T|PTPRD_uc003zkr.2_Missense_Mutation_p.A414T|PTPRD_uc003zks.2_Missense_Mutation_p.A410T|PTPRD_uc003zkl.2_Missense_Mutation_p.A420T|PTPRD_uc003zkm.2_Missense_Mutation_p.A407T|PTPRD_uc003zkn.2_Missense_Mutation_p.A420T|PTPRD_uc003zko.2_Missense_Mutation_p.A417T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	420	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8521543	8521543	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8521543C>T	uc003zkk.2	-	19	1406	c.695G>A	c.(694-696)CGC>CAC	p.R232H	PTPRD_uc003zkp.2_Missense_Mutation_p.R232H|PTPRD_uc003zkq.2_Missense_Mutation_p.R232H|PTPRD_uc003zkr.2_Missense_Mutation_p.R226H|PTPRD_uc003zks.2_Missense_Mutation_p.R222H|PTPRD_uc003zkl.2_Missense_Mutation_p.R232H|PTPRD_uc003zkm.2_Missense_Mutation_p.R219H|PTPRD_uc003zkn.2_Missense_Mutation_p.R232H|PTPRD_uc003zko.2_Missense_Mutation_p.R229H	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	232	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14746967	14746967	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14746967T>C	uc003zlm.2	-	34	6682	c.6092A>G	c.(6091-6093)TAT>TGT	p.Y2031C	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.Y567C	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2031					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
C9orf93	203238	broad.mit.edu	37	9	15777690	15777690	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15777690T>C	uc003zmd.2	+	19	3079	c.2764T>C	c.(2764-2766)TGT>CGT	p.C922R	C9orf93_uc003zme.2_Missense_Mutation_p.C837R|C9orf93_uc011lmu.1_Missense_Mutation_p.C930R|C9orf93_uc003zmf.1_Missense_Mutation_p.C230R	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	922											0				GBM - Glioblastoma multiforme(50;4.84e-07)														---	---	---	---
C9orf93	203238	broad.mit.edu	37	9	15777832	15777832	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15777832T>C	uc003zmd.2	+						C9orf93_uc003zme.2_Intron|C9orf93_uc011lmu.1_Intron|C9orf93_uc003zmf.1_Intron	NM_173550	NP_775821			hypothetical protein LOC203238												0				GBM - Glioblastoma multiforme(50;4.84e-07)														---	---	---	---
ADAMTSL1	92949	broad.mit.edu	37	9	18675914	18675914	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:18675914A>G	uc003zne.3	+						ADAMTSL1_uc003znb.2_Intron|ADAMTSL1_uc003znc.3_Intron	NM_001040272	NP_001035362			ADAMTS-like 1 isoform 4 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)														---	---	---	---
HAUS6	54801	broad.mit.edu	37	9	19083042	19083042	+	Splice_Site	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19083042C>A	uc003znk.2	-	8	953	c.700_splice	c.e8-1	p.V234_splice	HAUS6_uc011lmz.1_Splice_Site|HAUS6_uc003znl.1_Splice_Site_p.V98_splice|HAUS6_uc003znm.1_Splice_Site	NM_017645	NP_060115			HAUS augmin-like complex, subunit 6						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2																		---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20923715	20923715	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20923715T>C	uc003zog.1	+	27	3272	c.2909T>C	c.(2908-2910)GTC>GCC	p.V970A	KIAA1797_uc003zoh.1_Missense_Mutation_p.V406A	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	970						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
KIAA1797	54914	broad.mit.edu	37	9	20976409	20976409	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:20976409T>C	uc003zog.1	+						KIAA1797_uc003zoh.1_Intron	NM_017794	NP_060264			hypothetical protein LOC54914							integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)														---	---	---	---
IFNB1	3456	broad.mit.edu	37	9	21077708	21077708	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21077708T>G	uc003zok.2	-	1	236	c.161A>C	c.(160-162)AAG>ACG	p.K54T		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	54					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)													---	---	---	---
IFNA17	3451	broad.mit.edu	37	9	21227977	21227977	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21227977A>G	uc003zos.1	-	1	245	c.196T>C	c.(196-198)TTT>CTT	p.F66L	IFNA14_uc003zoo.1_Intron	NM_021268	NP_067091	P01571	IFN17_HUMAN	interferon, alpha 17 precursor	66					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)														---	---	---	---
IFNA5	3442	broad.mit.edu	37	9	21304924	21304924	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21304924T>C	uc011lnh.1	-	1	332	c.332A>G	c.(331-333)GAA>GGA	p.E111G		NM_002169	NP_002160	P01569	IFNA5_HUMAN	interferon, alpha 5 precursor	111					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			ovary(1)	1				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)														---	---	---	---
IFNA1	3439	broad.mit.edu	37	9	21441040	21441040	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21441040A>G	uc003zpd.1	+	1	601	c.534A>G	c.(532-534)TCA>TCG	p.S178S		NM_024013	NP_076918	P01562	IFNA1_HUMAN	interferon, alpha 1 precursor	178					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(2)	2				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)														---	---	---	---
IFNA1	3439	broad.mit.edu	37	9	21441041	21441041	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:21441041A>G	uc003zpd.1	+	1	602	c.535A>G	c.(535-537)ACA>GCA	p.T179A		NM_024013	NP_076918	P01562	IFNA1_HUMAN	interferon, alpha 1 precursor	179					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(2)	2				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0173)														---	---	---	---
PLAA	9373	broad.mit.edu	37	9	26920381	26920381	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26920381A>G	uc003zqd.2	-	8	1466	c.1041T>C	c.(1039-1041)GGT>GGC	p.G347G	PLAA_uc003zqe.2_Silent_p.G347G	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	347					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)														---	---	---	---
LRRC19	64922	broad.mit.edu	37	9	26998038	26998038	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26998038T>C	uc003zqh.2	-	3	394	c.283A>G	c.(283-285)AAC>GAC	p.N95D	IFT74_uc010mja.2_Intron|IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_022901	NP_075052	Q9H756	LRC19_HUMAN	leucine rich repeat containing 19 precursor	95	Extracellular (Potential).|LRR 2.					integral to membrane					0		all_neural(11;1.81e-09)		Lung(218;1.06e-05)|LUSC - Lung squamous cell carcinoma(38;0.0001)														---	---	---	---
IFT74	80173	broad.mit.edu	37	9	27009025	27009025	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27009025A>G	uc010mja.2	+	9	722	c.595A>G	c.(595-597)AAA>GAA	p.K199E	IFT74_uc010mjb.2_Missense_Mutation_p.K199E|IFT74_uc003zqf.3_Missense_Mutation_p.K199E|IFT74_uc003zqg.3_Missense_Mutation_p.K199E	NM_001099223	NP_001092693	Q96LB3	IFT74_HUMAN	coiled-coil domain containing 2 isoform a	199	Potential.					cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)														---	---	---	---
TEK	7010	broad.mit.edu	37	9	27109651	27109651	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27109651G>A	uc003zqi.3	+						TEK_uc010mjc.1_Intron|TEK_uc011lnn.1_Intron|TEK_uc011lno.1_Intron|TEK_uc011lnp.1_Intron	NM_000459	NP_000450			TEK tyrosine kinase, endothelial precursor						angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)														---	---	---	---
DDX58	23586	broad.mit.edu	37	9	32485235	32485235	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32485235T>C	uc003zra.2	-	10	1576	c.1418A>G	c.(1417-1419)TAC>TGC	p.Y473C	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Missense_Mutation_p.Y428C|DDX58_uc011lnr.1_Missense_Mutation_p.Y270C|DDX58_uc010mji.2_Missense_Mutation_p.Y402C	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	473					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)														---	---	---	---
APTX	54840	broad.mit.edu	37	9	32987768	32987768	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32987768A>G	uc003zrm.2	-	3	454	c.257T>C	c.(256-258)GTT>GCT	p.V86A	APTX_uc010mjm.2_Intron|APTX_uc003zrj.2_5'UTR|APTX_uc011lns.1_Intron|APTX_uc003zrl.2_Intron|APTX_uc003zrn.2_5'UTR|APTX_uc003zro.2_Missense_Mutation_p.V86A|APTX_uc003zrp.2_5'UTR|APTX_uc003zrq.2_5'UTR|APTX_uc003zrr.2_Intron|APTX_uc003zrs.2_Missense_Mutation_p.V86A|APTX_uc003zrt.2_5'UTR|APTX_uc003zru.2_Intron|APTX_uc003zrv.2_Missense_Mutation_p.V100A|APTX_uc003zrw.2_Missense_Mutation_p.V86A|APTX_uc003zrx.2_Missense_Mutation_p.V86A|APTX_uc003zry.2_Missense_Mutation_p.V86A|APTX_uc003zrz.2_Intron|APTX_uc003zsa.1_Intron|APTX_uc003zsb.1_Intron|APTX_uc003zsc.1_Intron	NM_175072	NP_778242	Q7Z2E3	APTX_HUMAN	aprataxin isoform c	100	Interactions with ADPRT and NCL.				cell death|double-strand break repair|regulation of protein stability|response to hydrogen peroxide|single strand break repair	chromatin|nucleolus|nucleoplasm	chromatin binding|damaged DNA binding|DNA 5'-adenosine monophosphate hydrolase activity|double-stranded DNA binding|double-stranded RNA binding|phosphoglycolate phosphatase activity|phosphoprotein binding|polynucleotide 3'-phosphatase activity|protein N-terminus binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0302)	GBM - Glioblastoma multiforme(74;0.105)									Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
DNAJA1	3301	broad.mit.edu	37	9	33038770	33038770	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33038770A>G	uc003zsd.1	+	9	1246	c.1063A>G	c.(1063-1065)ACT>GCT	p.T355A	DNAJA1_uc011lnt.1_Missense_Mutation_p.T198A	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	355					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)														---	---	---	---
SMU1	55234	broad.mit.edu	37	9	33053213	33053213	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33053213C>T	uc003zsf.1	-	10	1306	c.1198G>A	c.(1198-1200)GTC>ATC	p.V400I	SMU1_uc010mjo.1_Missense_Mutation_p.V400I|SMU1_uc010mjp.1_Intron|SMU1_uc011lnu.1_Missense_Mutation_p.V239I	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	400	WD 5.					cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)														---	---	---	---
B4GALT1	2683	broad.mit.edu	37	9	33120581	33120581	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33120581A>G	uc003zsg.2	-	3	861	c.672T>C	c.(670-672)CGT>CGC	p.R224R		NM_001497	NP_001488	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	224	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)													---	---	---	---
AQP7	364	broad.mit.edu	37	9	33386157	33386157	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33386157A>G	uc003zst.2	-	6	615	c.443T>C	c.(442-444)GTG>GCG	p.V148A	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Missense_Mutation_p.V91A|AQP7_uc010mjs.2_Missense_Mutation_p.V56A|AQP7_uc010mjt.2_Missense_Mutation_p.V56A|AQP7_uc011lnx.1_Missense_Mutation_p.V148A|AQP7_uc011lny.1_Missense_Mutation_p.V147A|AQP7_uc003zss.3_Missense_Mutation_p.V56A|AQP7_uc011lnz.1_Missense_Mutation_p.V56A|AQP7_uc011loa.1_Intron	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	148	Extracellular (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)														---	---	---	---
UBAP2	55833	broad.mit.edu	37	9	33948577	33948577	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33948577G>A	uc003ztq.1	-	13	1178	c.1065C>T	c.(1063-1065)GTC>GTT	p.V355V	UBAP2_uc011loc.1_Silent_p.V264V|UBAP2_uc011lod.1_Silent_p.V88V|UBAP2_uc011loe.1_Silent_p.V110V|UBAP2_uc011lof.1_Silent_p.V280V|UBAP2_uc011log.1_Silent_p.V301V|UBAP2_uc003ztr.2_Silent_p.V227V|UBAP2_uc003zts.2_5'UTR	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	355										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)														---	---	---	---
DNAI1	27019	broad.mit.edu	37	9	34512331	34512331	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34512331A>G	uc003zum.2	+							NM_012144	NP_036276			dynein, axonemal, intermediate chain 1						cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity				0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)										Kartagener_syndrome				---	---	---	---
C9orf23	138716	broad.mit.edu	37	9	34611198	34611198	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34611198A>G	uc003zuu.2	-	2	377	c.96T>C	c.(94-96)GAT>GAC	p.D32D	C9orf23_uc003zuv.2_Silent_p.D32D	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	hypothetical protein LOC138716	32							nucleic acid binding				0	all_epithelial(49;0.0863)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.0385)														---	---	---	---
ARID3C	138715	broad.mit.edu	37	9	34622508	34622508	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34622508T>C	uc011lon.1	-	5	884	c.884A>G	c.(883-885)AAC>AGC	p.N295S	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	295	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)														---	---	---	---
SIGMAR1	10280	broad.mit.edu	37	9	34635783	34635783	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34635783T>C	uc003zvb.2	-	4	592	c.518A>G	c.(517-519)TAC>TGC	p.Y173C	SIGMAR1_uc003zva.3_Missense_Mutation_p.Y153C|SIGMAR1_uc003zuz.2_Missense_Mutation_p.Y84C|SIGMAR1_uc003zvc.2_Missense_Mutation_p.Y142C|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	173	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)													---	---	---	---
PIGO	84720	broad.mit.edu	37	9	35091856	35091856	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35091856C>T	uc003zwd.2	-	7	2424	c.2028G>A	c.(2026-2028)GCG>GCA	p.A676A	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Silent_p.A239A	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	676	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)															---	---	---	---
STOML2	30968	broad.mit.edu	37	9	35100102	35100102	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35100102C>A	uc003zwi.2	-	10	1064	c.1001G>T	c.(1000-1002)GGG>GTG	p.G334V	STOML2_uc003zwh.2_Missense_Mutation_p.G225V|STOML2_uc003zwj.2_Missense_Mutation_p.G225V|STOML2_uc011lou.1_Missense_Mutation_p.G289V|STOML2_uc003zwk.2_Missense_Mutation_p.G283V	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	stomatin (EPB72)-like 2	334						cytoskeleton	receptor binding				0			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)															---	---	---	---
UNC13B	10497	broad.mit.edu	37	9	35378381	35378381	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35378381A>G	uc003zwq.2	+	16	2198	c.1906A>G	c.(1906-1908)ACC>GCC	p.T636A	UNC13B_uc003zwr.2_Missense_Mutation_p.T636A	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	636	C2 2.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
UNC13B	10497	broad.mit.edu	37	9	35403993	35403993	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35403993T>A	uc003zwq.2	+	39	5031	c.4739T>A	c.(4738-4740)CTC>CAC	p.L1580H	UNC13B_uc003zwr.2_Missense_Mutation_p.L1599H|ATP8B5P_uc010mkn.1_5'Flank|ATP8B5P_uc010mko.2_5'Flank|ATP8B5P_uc010mkp.2_5'Flank|ATP8B5P_uc003zwu.2_5'Flank	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1580					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
RUSC2	9853	broad.mit.edu	37	9	35547398	35547398	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35547398A>G	uc003zww.2	+	2	1135	c.880A>G	c.(880-882)ACC>GCC	p.T294A	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.T294A	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	294						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TESK1	7016	broad.mit.edu	37	9	35609379	35609379	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35609379C>T	uc003zxa.2	+	10	1857	c.1521C>T	c.(1519-1521)TCC>TCT	p.S507S	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Silent_p.S347S	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	507					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TLN1	7094	broad.mit.edu	37	9	35707150	35707150	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35707150C>T	uc003zxt.2	-	37	5228	c.4874G>A	c.(4873-4875)CGG>CAG	p.R1625Q		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1625	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TLN1	7094	broad.mit.edu	37	9	35723937	35723937	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35723937T>C	uc003zxt.2	-						TLN1_uc003zxu.3_3'UTR	NM_006289	NP_006280			talin 1						axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TMEM8B	51754	broad.mit.edu	37	9	35852855	35852855	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35852855T>C	uc003zym.2	+	12	1866	c.851T>C	c.(850-852)GTG>GCG	p.V284A	TMEM8B_uc003zyo.2_Missense_Mutation_p.V284A	NM_001042589	NP_001036054	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B isoform a	284	Extracellular (Potential).				cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			ovary(1)	1																		---	---	---	---
MELK	9833	broad.mit.edu	37	9	36643018	36643018	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36643018G>A	uc003zzn.2	+	11	997	c.859G>A	c.(859-861)GTA>ATA	p.V287I	MELK_uc011lpm.1_Missense_Mutation_p.V156I|MELK_uc011lpn.1_Missense_Mutation_p.V287I|MELK_uc011lpo.1_Missense_Mutation_p.V93I|MELK_uc010mll.2_Missense_Mutation_p.V255I|MELK_uc011lpp.1_Missense_Mutation_p.V239I|MELK_uc010mlm.2_Missense_Mutation_p.V216I|MELK_uc011lpq.1_Missense_Mutation_p.V93I|MELK_uc011lpr.1_Missense_Mutation_p.V216I|MELK_uc011lps.1_Missense_Mutation_p.V207I	NM_014791	NP_055606	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	287						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
FBXO10	26267	broad.mit.edu	37	9	37541449	37541449	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37541449T>C	uc004aab.2	-	2	366	c.317A>G	c.(316-318)GAA>GGA	p.E106G	FBXO10_uc004aac.2_Missense_Mutation_p.E122G|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	106						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)														---	---	---	---
FRMPD1	22844	broad.mit.edu	37	9	37745884	37745884	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37745884T>C	uc004aag.1	+	16	3899	c.3855T>C	c.(3853-3855)TCT>TCC	p.S1285S	FRMPD1_uc004aah.1_Silent_p.S1285S	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1285						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)														---	---	---	---
RG9MTD3	158234	broad.mit.edu	37	9	37768227	37768227	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37768227T>C	uc004aai.2	+	5	650	c.573_splice	c.e5+2	p.L191_splice	RG9MTD3_uc011lqo.1_Intron|RG9MTD3_uc011lqp.1_Splice_Site_p.L113_splice|RG9MTD3_uc011lqq.1_Splice_Site_p.L80_splice|RG9MTD3_uc004aaj.2_Splice_Site|RG9MTD3_uc004aak.2_Splice_Site_p.L96_splice	NM_144964	NP_659401			RNA (guanine-9-) methyltransferase domain								methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)														---	---	---	---
ALDH1B1	219	broad.mit.edu	37	9	38397185	38397185	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:38397185G>A	uc004aay.2	+	2	1552	c.1440G>A	c.(1438-1440)ACG>ACA	p.T480T		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	480					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)													---	---	---	---
ZNF658	26149	broad.mit.edu	37	9	40774856	40774856	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40774856T>C	uc004abs.2	-	5	571	c.419A>G	c.(418-420)GAC>GGC	p.D140G	ZNF658_uc010mmm.1_Missense_Mutation_p.D140G|ZNF658_uc010mmn.1_Missense_Mutation_p.D140G	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)														---	---	---	---
PRKACG	5568	broad.mit.edu	37	9	71628684	71628684	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71628684A>G	uc004agy.2	-	1	356	c.325T>C	c.(325-327)TTC>CTC	p.F109L		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	109	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
PRKACG	5568	broad.mit.edu	37	9	71628958	71628958	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71628958G>A	uc004agy.2	-	1	82	c.51C>T	c.(49-51)AAC>AAT	p.N17N		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	17					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
C9orf135	138255	broad.mit.edu	37	9	72501762	72501762	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72501762T>A	uc004ahl.2	+	5	523	c.458T>A	c.(457-459)TTG>TAG	p.L153*	C9orf135_uc011lrw.1_Nonsense_Mutation_p.L45*|C9orf135_uc010moq.2_Nonsense_Mutation_p.L45*|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Intron	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	153	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1																		---	---	---	---
TRPM3	80036	broad.mit.edu	37	9	73151634	73151634	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:73151634T>C	uc004aid.2	-	25	4603	c.4359A>G	c.(4357-4359)AGA>AGG	p.R1453R	TRPM3_uc004ahu.2_Silent_p.R1295R|TRPM3_uc004ahv.2_Silent_p.R1255R|TRPM3_uc004ahw.2_Silent_p.R1325R|TRPM3_uc004ahx.2_Silent_p.R1312R|TRPM3_uc004ahy.2_Silent_p.R1315R|TRPM3_uc004ahz.2_Silent_p.R1302R|TRPM3_uc004aia.2_Silent_p.R1300R|TRPM3_uc004aib.2_Silent_p.R1290R|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1478	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9																		---	---	---	---
TRPM3	80036	broad.mit.edu	37	9	73213424	73213424	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:73213424C>T	uc004aid.2	-	20	3167	c.2923G>A	c.(2923-2925)GTG>ATG	p.V975M	TRPM3_uc004ahu.2_Missense_Mutation_p.V805M|TRPM3_uc004ahv.2_Missense_Mutation_p.V777M|TRPM3_uc004ahw.2_Missense_Mutation_p.V847M|TRPM3_uc004ahx.2_Missense_Mutation_p.V834M|TRPM3_uc004ahy.2_Missense_Mutation_p.V837M|TRPM3_uc004ahz.2_Missense_Mutation_p.V824M|TRPM3_uc004aia.2_Missense_Mutation_p.V822M|TRPM3_uc004aib.2_Missense_Mutation_p.V812M|TRPM3_uc004aic.2_Missense_Mutation_p.V975M	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1000	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9																		---	---	---	---
ALDH1A1	216	broad.mit.edu	37	9	75524662	75524662	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:75524662A>G	uc004ajd.2	-	11	1267	c.1214T>C	c.(1213-1215)GTG>GCG	p.V405A	ALDH1A1_uc011lsh.1_Missense_Mutation_p.V326A|ALDH1A1_uc011lsg.1_Missense_Mutation_p.V231A	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	405					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)													---	---	---	---
RORB	6096	broad.mit.edu	37	9	77257488	77257488	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77257488A>G	uc004aji.2	+	4	476	c.427A>G	c.(427-429)AAC>GAC	p.N143D	RORB_uc004ajh.2_Missense_Mutation_p.N132D	NM_006914	NP_008845	Q92753	RORB_HUMAN	RAR-related orphan receptor B	143	Hinge (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
TRPM6	140803	broad.mit.edu	37	9	77435270	77435270	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77435270A>G	uc004ajl.1	-	9	1322	c.1084T>C	c.(1084-1086)TCC>CCC	p.S362P	TRPM6_uc004ajk.1_Missense_Mutation_p.S357P|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.S362P|TRPM6_uc010mpd.1_Missense_Mutation_p.S362P|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	362	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
OSTF1	26578	broad.mit.edu	37	9	77755814	77755814	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77755814C>T	uc004ajv.3	+	9	763	c.552C>T	c.(550-552)GCC>GCT	p.A184A	OSTF1_uc004ajw.3_Silent_p.A141A|OSTF1_uc004ajx.3_Silent_p.A187A	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	184					ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78711023	78711023	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78711023G>A	uc004ajz.2	+						PCSK5_uc004ajy.2_Intron|PCSK5_uc004aka.2_Intron	NM_006200	NP_006191			proprotein convertase subtilisin/kexin type 5						anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
PCSK5	5125	broad.mit.edu	37	9	78749046	78749046	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78749046C>T	uc004ajz.2	+	10	1768	c.1230C>T	c.(1228-1230)GAC>GAT	p.D410D	PCSK5_uc004ajy.2_Silent_p.D410D|PCSK5_uc004aka.2_Intron	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	410	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	78947412	78947412	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78947412C>T	uc004akc.1	+	6	1029	c.809C>T	c.(808-810)GCC>GTC	p.A270V						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																														---	---	---	---
Unknown	0	broad.mit.edu	37	9	78953321	78953321	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78953321C>T	uc004akc.1	+	7	1319	c.1099C>T	c.(1099-1101)CAG>TAG	p.Q367*						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																														---	---	---	---
Unknown	0	broad.mit.edu	37	9	78973828	78973828	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78973828A>G	uc004akc.1	+	10	2049	c.1829A>G	c.(1828-1830)TAC>TGC	p.Y610C						Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.																														---	---	---	---
PRUNE2	158471	broad.mit.edu	37	9	79321580	79321580	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79321580T>C	uc010mpk.2	-	8	5734	c.5610A>G	c.(5608-5610)GTA>GTG	p.V1870V	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1870					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0																		---	---	---	---
FOXB2	442425	broad.mit.edu	37	9	79634951	79634951	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79634951G>A	uc004ako.1	+	1	381	c.381G>A	c.(379-381)GCG>GCA	p.A127A		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	127					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0																		---	---	---	---
VPS13A	23230	broad.mit.edu	37	9	79952387	79952387	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79952387A>G	uc004akr.2	+	47	6572	c.6312A>G	c.(6310-6312)ATA>ATG	p.I2104M	VPS13A_uc004akp.3_Missense_Mutation_p.I2104M|VPS13A_uc004akq.3_Missense_Mutation_p.I2104M|VPS13A_uc004aks.2_Missense_Mutation_p.I2065M|VPS13A_uc004akt.2_Missense_Mutation_p.I444M	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2104					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10																		---	---	---	---
TLE4	7091	broad.mit.edu	37	9	82308557	82308557	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:82308557A>G	uc004ald.2	+						TLE4_uc004alc.2_Intron|TLE4_uc010mpr.2_Intron|TLE4_uc004ale.2_Intron|TLE4_uc011lsq.1_Intron|TLE4_uc010mps.2_Intron|TLE4_uc004alf.2_Intron	NM_007005	NP_008936			transducin-like enhancer protein 4											lung(2)|ovary(1)|breast(1)|skin(1)	5																		---	---	---	---
FRMD3	257019	broad.mit.edu	37	9	85925432	85925432	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:85925432T>G	uc004ams.1	-	9	1007	c.805A>C	c.(805-807)AAG>CAG	p.K269Q	FRMD3_uc004amr.1_Missense_Mutation_p.K255Q	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	269	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
UBQLN1	29979	broad.mit.edu	37	9	86292640	86292640	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86292640A>G	uc004amv.2	-	6	1679	c.1105_splice	c.e6+1	p.A369_splice	UBQLN1_uc004amw.2_Splice_Site_p.A369_splice	NM_013438	NP_038466			ubiquilin 1 isoform 1						apoptosis|regulation of protein ubiquitination|response to hypoxia	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm|proteasome complex	kinase binding				0																		---	---	---	---
GKAP1	80318	broad.mit.edu	37	9	86357453	86357453	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86357453T>C	uc004amy.2	-	11	1463	c.967A>G	c.(967-969)ACT>GCT	p.T323A	GKAP1_uc004amz.2_Missense_Mutation_p.T272A	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	323	Potential.				signal transduction	Golgi apparatus					0																		---	---	---	---
AGTPBP1	23287	broad.mit.edu	37	9	88236136	88236136	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88236136A>G	uc011ltd.1	-	14	2113	c.2080T>C	c.(2080-2082)TAT>CAT	p.Y694H	AGTPBP1_uc004aod.3_Missense_Mutation_p.Y320H|AGTPBP1_uc011ltc.1_Missense_Mutation_p.Y592H|AGTPBP1_uc010mqc.2_Missense_Mutation_p.Y654H|AGTPBP1_uc011lte.1_Missense_Mutation_p.Y706H	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	694					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7																		---	---	---	---
CTSL3	392360	broad.mit.edu	37	9	90388469	90388469	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:90388469C>T	uc004apm.1	+	3	335	c.329C>T	c.(328-330)GCT>GTT	p.A110V		NR_027917				RecName: Full=Putative cathepsin L-like protein 3;          Short=Cathepsin L-like protein; AltName: Full=HCTSL-s;									p.M110V(1)		ovary(1)	1																		---	---	---	---
IARS	3376	broad.mit.edu	37	9	95050089	95050089	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95050089T>A	uc004art.1	-	4	637	c.380A>T	c.(379-381)TAT>TTT	p.Y127F	IARS_uc004ars.1_5'UTR|IARS_uc004aru.3_Missense_Mutation_p.Y127F|IARS_uc010mqr.2_Missense_Mutation_p.Y17F|IARS_uc010mqt.2_Intron	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	127					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)													---	---	---	---
OGN	4969	broad.mit.edu	37	9	95165630	95165630	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95165630T>C	uc004asa.2	-	2	295	c.60A>G	c.(58-60)GCA>GCG	p.A20A	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Silent_p.A20A|OGN_uc011ltx.1_Silent_p.A38A	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein	20						extracellular space|proteinaceous extracellular matrix	growth factor activity				0																		---	---	---	---
IPPK	64768	broad.mit.edu	37	9	95378327	95378327	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95378327C>T	uc004asl.1	-	13	1540	c.1263G>A	c.(1261-1263)AGG>AGA	p.R421R	IPPK_uc004ask.1_Silent_p.R120R|uc004asm.2_5'Flank	NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	421					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2																		---	---	---	---
IPPK	64768	broad.mit.edu	37	9	95432206	95432206	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95432206A>G	uc004asl.1	-	1	342	c.65T>C	c.(64-66)GTG>GCG	p.V22A		NM_022755	NP_073592	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	22					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			ovary(2)	2																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	95947742	95947742	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95947742G>C	uc004ati.1	+	1	531	c.531G>C	c.(529-531)GAG>GAC	p.E177D	WNK2_uc011lud.1_Missense_Mutation_p.E177D|WNK2_uc004atj.2_Missense_Mutation_p.E177D|WNK2_uc010mrc.1_Missense_Mutation_p.E177D	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	177					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	95947835	95947835	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95947835G>A	uc004ati.1	+	1	624	c.624G>A	c.(622-624)ACG>ACA	p.T208T	WNK2_uc011lud.1_Silent_p.T208T|WNK2_uc004atj.2_Silent_p.T208T|WNK2_uc010mrc.1_Silent_p.T208T	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	208	ATP (By similarity).|Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
FAM120A	23196	broad.mit.edu	37	9	96323469	96323469	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96323469G>A	uc004atw.2	+	16	2910	c.2885G>A	c.(2884-2886)CGG>CAG	p.R962Q	FAM120A_uc004aty.2_Missense_Mutation_p.R743Q|FAM120A_uc004atz.2_Missense_Mutation_p.R610Q|FAM120A_uc010mrg.2_Missense_Mutation_p.R229Q|FAM120A_uc004aua.1_5'Flank	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	962	RNA binding.					cytoplasm|plasma membrane	RNA binding				0																		---	---	---	---
PTPDC1	138639	broad.mit.edu	37	9	96847621	96847621	+	Silent	SNP	G	A	A	rs149606330	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96847621G>A	uc004auf.1	+	3	511	c.171G>A	c.(169-171)GCG>GCA	p.A57A	PTPDC1_uc004aug.1_Silent_p.A57A|PTPDC1_uc004auh.1_Silent_p.A109A|PTPDC1_uc010mrj.1_Silent_p.A111A|PTPDC1_uc010mri.1_Silent_p.A109A	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	57							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1																		---	---	---	---
FANCC	2176	broad.mit.edu	37	9	97887409	97887409	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:97887409T>C	uc004avh.2	-	10	1217	c.955A>G	c.(955-957)ACG>GCG	p.T319A	FANCC_uc004avi.3_Missense_Mutation_p.T319A|uc004avj.2_5'Flank	NM_000136	NP_000127	Q00597	FANCC_HUMAN	Fanconi anemia, complementation group C	319					protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)						D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
PTCH1	5727	broad.mit.edu	37	9	98231280	98231280	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98231280T>C	uc004avk.3	-	14	2191	c.2003A>G	c.(2002-2004)TAC>TGC	p.Y668C	PTCH1_uc010mro.2_Missense_Mutation_p.Y517C|PTCH1_uc010mrp.2_Missense_Mutation_p.Y517C|PTCH1_uc010mrq.2_Missense_Mutation_p.Y517C|PTCH1_uc004avl.3_Missense_Mutation_p.Y517C|PTCH1_uc010mrr.2_Missense_Mutation_p.Y602C|PTCH1_uc004avm.3_Missense_Mutation_p.Y667C|PTCH1_uc010mrs.1_Missense_Mutation_p.Y336C	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	668	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.Y668Y(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)												Basal_Cell_Nevus_syndrome				---	---	---	---
C9orf102	375748	broad.mit.edu	37	9	98683534	98683534	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98683534A>G	uc004avt.3	+	7	1657	c.1269A>G	c.(1267-1269)ATA>ATG	p.I423M	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.I125M|C9orf102_uc010mry.1_Missense_Mutation_p.I125M|C9orf102_uc010mrz.2_Missense_Mutation_p.I234M|C9orf102_uc004avu.2_5'Flank	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	423					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
C9orf102	375748	broad.mit.edu	37	9	98740497	98740497	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98740497G>T	uc004avu.2	+	12	2610	c.1365G>T	c.(1363-1365)AAG>AAT	p.K455N	uc010msa.1_Missense_Mutation_p.K145N|uc011lun.1_Missense_Mutation_p.K145N			Q5T890	RAD26_HUMAN	Homo sapiens cDNA, FLJ97452.	Error:Variant_position_missing_in_Q5T890_after_alignment					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
FAM22G	441457	broad.mit.edu	37	9	99699428	99699428	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99699428G>T	uc004awq.1	+	5	1780	c.1065G>T	c.(1063-1065)AAG>AAT	p.K355N	HIATL2_uc004awr.1_Intron	NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	355	Pro-rich.									skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
KIAA1529	57653	broad.mit.edu	37	9	100120005	100120005	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100120005A>G	uc011lut.1	+	37	4683	c.3910A>G	c.(3910-3912)ACC>GCC	p.T1304A	KIAA1529_uc004axe.1_Missense_Mutation_p.T1136A|KIAA1529_uc004axg.1_Missense_Mutation_p.T1165A|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Missense_Mutation_p.T321A	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)																---	---	---	---
TBC1D2	55357	broad.mit.edu	37	9	100983263	100983263	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100983263T>C	uc011lvb.1	-	6	1406	c.1226A>G	c.(1225-1227)GAC>GGC	p.D409G	TBC1D2_uc004ayq.2_Missense_Mutation_p.D409G|TBC1D2_uc004ayr.2_Missense_Mutation_p.D191G|TBC1D2_uc004ayo.3_Missense_Mutation_p.D409G	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	409	Potential.|Interaction with RAC1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)														---	---	---	---
COL15A1	1306	broad.mit.edu	37	9	101748054	101748054	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101748054G>A	uc004azb.1	+	3	514	c.308G>A	c.(307-309)CGT>CAT	p.R103H	COL15A1_uc004aza.2_Missense_Mutation_p.R103H	NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	103	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---
INVS	27130	broad.mit.edu	37	9	103035332	103035332	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103035332A>G	uc004bap.1	+	12	1970	c.1758A>G	c.(1756-1758)GAA>GAG	p.E586E	INVS_uc010mta.1_Silent_p.E490E|INVS_uc011lve.1_Silent_p.E490E|INVS_uc004bao.1_Silent_p.E586E|INVS_uc004baq.1_Silent_p.E490E|INVS_uc004bar.1_Silent_p.E490E|INVS_uc010mtb.1_Silent_p.E260E	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	586					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)																---	---	---	---
C9orf30	91283	broad.mit.edu	37	9	103213194	103213194	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103213194T>C	uc004baw.2	+	3	841	c.774T>C	c.(772-774)TTT>TTC	p.F258F	TMEFF1_uc004bay.1_Intron|C9orf30_uc004bax.2_RNA	NM_080655	NP_542386	Q96H12	CI030_HUMAN	hypothetical protein LOC91283	258										ovary(1)	1		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
ALDOB	229	broad.mit.edu	37	9	104187728	104187728	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:104187728G>A	uc004bbk.2	-							NM_000035	NP_000026			aldolase B, fructose-bisphosphate						fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
ABCA1	19	broad.mit.edu	37	9	107594877	107594877	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:107594877C>T	uc004bcl.2	-	12	1800	c.1487G>A	c.(1486-1488)CGG>CAG	p.R496Q		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	496	Extracellular.		R -> W (associated with increased plasma HDL cholesterol).		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
SLC44A1	23446	broad.mit.edu	37	9	108118594	108118594	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108118594T>C	uc004bcn.2	+	6	823	c.602T>C	c.(601-603)TTA>TCA	p.L201S	SLC44A1_uc010mtk.1_Missense_Mutation_p.L201S|SLC44A1_uc004bco.1_5'UTR	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	201	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)													---	---	---	---
SLC44A1	23446	broad.mit.edu	37	9	108118607	108118607	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108118607T>C	uc004bcn.2	+	6	836	c.615T>C	c.(613-615)ATT>ATC	p.I205I	SLC44A1_uc010mtk.1_Silent_p.I205I|SLC44A1_uc004bco.1_5'UTR	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	205	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)													---	---	---	---
TMEM38B	55151	broad.mit.edu	37	9	108536265	108536265	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:108536265A>G	uc004bcu.1	+	6	897	c.780A>G	c.(778-780)GCA>GCG	p.A260A	TMEM38B_uc010mtn.1_3'UTR	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	260	Cytoplasmic (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2																		---	---	---	---
ZNF462	58499	broad.mit.edu	37	9	109734375	109734375	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:109734375C>T	uc004bcz.2	+	8	6806	c.6517C>T	c.(6517-6519)CCT>TCT	p.P2173S	ZNF462_uc010mto.2_Missense_Mutation_p.P2082S|ZNF462_uc004bda.2_Missense_Mutation_p.P2081S|ZNF462_uc011lvz.1_Missense_Mutation_p.P130S|ZNF462_uc004bdb.1_Missense_Mutation_p.P81S	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2173					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5																		---	---	---	---
KLF4	9314	broad.mit.edu	37	9	110250404	110250404	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:110250404G>A	uc004bdh.2	-	3	865	c.244C>T	c.(244-246)CTA>TTA	p.L82L	KLF4_uc004bdf.1_Silent_p.L41L|KLF4_uc004bdg.2_Silent_p.L91L	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	91					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3																		---	---	---	---
ACTL7A	10881	broad.mit.edu	37	9	111625200	111625200	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111625200T>C	uc004bdj.1	+	1	598	c.598T>C	c.(598-600)TAC>CAC	p.Y200H		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	200						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0																		---	---	---	---
ACTL7A	10881	broad.mit.edu	37	9	111625720	111625720	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111625720G>A	uc004bdj.1	+	1	1118	c.1118G>A	c.(1117-1119)CGT>CAT	p.R373H		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	373						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0																		---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111663739	111663739	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111663739G>A	uc004bdm.3	-	18	2500	c.1980C>T	c.(1978-1980)TGC>TGT	p.C660C	IKBKAP_uc004bdl.2_Silent_p.C311C|IKBKAP_uc011lwc.1_Silent_p.C546C|IKBKAP_uc010mtq.2_Silent_p.C311C	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	660					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111681604	111681604	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111681604T>C	uc004bdm.3	-	7	1098	c.578A>G	c.(577-579)GAC>GGC	p.D193G	IKBKAP_uc004bdl.2_5'Flank|IKBKAP_uc011lwc.1_Missense_Mutation_p.D79G|IKBKAP_uc010mtq.2_Intron	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	193					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
CTNNAL1	8727	broad.mit.edu	37	9	111706106	111706106	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111706106A>G	uc004bdo.1	-						CTNNAL1_uc010mts.1_Intron|CTNNAL1_uc010mtt.1_Intron|CTNNAL1_uc004bdp.1_Intron|CTNNAL1_uc004bdq.1_Intron	NM_003798	NP_003789			catenin, alpha-like 1						cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)														---	---	---	---
EPB41L4B	54566	broad.mit.edu	37	9	112029799	112029799	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112029799T>C	uc004bdz.1	-	4	782	c.487A>G	c.(487-489)AAA>GAA	p.K163E	EPB41L4B_uc004bea.2_Missense_Mutation_p.K163E	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	163	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
PTPN3	5774	broad.mit.edu	37	9	112166752	112166752	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112166752G>A	uc004bed.2	-	19	2041	c.1929C>T	c.(1927-1929)AGC>AGT	p.S643S	PTPN3_uc004beb.2_Silent_p.S512S|PTPN3_uc004bec.2_Silent_p.S467S|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.S598S|PTPN3_uc011lwh.1_Silent_p.S489S|PTPN3_uc011lwd.1_Silent_p.S111S|PTPN3_uc011lwe.1_Silent_p.S356S|PTPN3_uc011lwf.1_Silent_p.S311S	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	643					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3																		---	---	---	---
SVEP1	79987	broad.mit.edu	37	9	113166770	113166770	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113166770C>T	uc010mtz.2	-	39	9840	c.9503G>A	c.(9502-9504)CGC>CAC	p.R3168H	SVEP1_uc010mty.2_Missense_Mutation_p.R1094H	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3168	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7																		---	---	---	---
MUSK	4593	broad.mit.edu	37	9	113530124	113530124	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113530124C>T	uc004bey.2	+	8	1043	c.945C>T	c.(943-945)GGC>GGT	p.G315G		NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	315	FZ.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---
MUSK	4593	broad.mit.edu	37	9	113547866	113547866	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113547866A>G	uc004bey.2	+	12	1744	c.1646A>G	c.(1645-1647)CAT>CGT	p.H549R	MUSK_uc004bez.1_Missense_Mutation_p.H129R	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	549	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114155165	114155165	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114155165A>G	uc004bfe.1	-							NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114184265	114184265	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114184265T>C	uc004bfe.1	-	16	1925	c.1925A>G	c.(1924-1926)TAT>TGT	p.Y642C	KIAA0368_uc010muc.1_Missense_Mutation_p.Y464C	NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
C9orf84	158401	broad.mit.edu	37	9	114490230	114490230	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114490230G>A	uc004bfr.2	-	11	1460	c.1325C>T	c.(1324-1326)GCA>GTA	p.A442V	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.A403V|C9orf84_uc010mug.2_Missense_Mutation_p.A388V	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	442										ovary(2)	2																		---	---	---	---
SUSD1	64420	broad.mit.edu	37	9	114911561	114911561	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114911561G>C	uc004bfu.2	-	3	377	c.336C>G	c.(334-336)AAC>AAG	p.N112K	SUSD1_uc010mui.2_Missense_Mutation_p.N112K|SUSD1_uc010muj.2_Missense_Mutation_p.N112K	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	112	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).					integral to membrane	calcium ion binding				0																		---	---	---	---
ROD1	9991	broad.mit.edu	37	9	114997101	114997101	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114997101T>C	uc004bfw.2	-	9	1150	c.963A>G	c.(961-963)ACA>ACG	p.T321T	ROD1_uc004bfv.2_Silent_p.T327T|ROD1_uc004bfx.2_Silent_p.T324T|ROD1_uc011lwu.1_Silent_p.T293T|ROD1_uc004bfy.2_Silent_p.T226T|ROD1_uc004bfz.2_Silent_p.T293T	NM_005156	NP_005147	O95758	ROD1_HUMAN	ROD1 regulator of differentiation 1 isoform 1	321					anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
BSPRY	54836	broad.mit.edu	37	9	116130558	116130558	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116130558A>G	uc004bhg.3	+	5	625	c.577A>G	c.(577-579)ATT>GTT	p.I193V	BSPRY_uc010muw.2_Intron	NM_017688	NP_060158	Q5W0U4	BSPRY_HUMAN	B-box and SPRY domain containing	193					calcium ion transport	cytoplasm|membrane	zinc ion binding			breast(1)	1																		---	---	---	---
HDHD3	81932	broad.mit.edu	37	9	116136524	116136524	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116136524C>T	uc004bhi.1	-	2	895	c.111G>A	c.(109-111)GGG>GGA	p.G37G	HDHD3_uc004bhj.2_Silent_p.G37G|HDHD3_uc004bhk.2_Silent_p.G37G	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	37							phosphoglycolate phosphatase activity|protein binding				0																		---	---	---	---
RGS3	5998	broad.mit.edu	37	9	116356778	116356778	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116356778C>T	uc004bhq.2	+	23	3358	c.3149C>T	c.(3148-3150)GCG>GTG	p.A1050V	RGS3_uc004bhs.2_Missense_Mutation_p.A940V|RGS3_uc004bht.2_Missense_Mutation_p.A769V|RGS3_uc010muy.2_Missense_Mutation_p.A443V|RGS3_uc004bhv.2_Missense_Mutation_p.A371V|RGS3_uc004bhw.2_Missense_Mutation_p.A20V|RGS3_uc011lxh.1_Missense_Mutation_p.A360V|RGS3_uc004bhx.2_Missense_Mutation_p.A371V|RGS3_uc004bhz.2_Missense_Mutation_p.A392V|RGS3_uc004bia.2_Missense_Mutation_p.A163V	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1050					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
ORM1	5004	broad.mit.edu	37	9	117087437	117087437	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117087437A>G	uc004bik.3	+						ORM1_uc011lxo.1_Intron	NM_000607	NP_000598			orosomucoid 1 precursor						acute-phase response|regulation of immune system process|transport	extracellular space	protein binding				0		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)													---	---	---	---
AKNA	80709	broad.mit.edu	37	9	117129918	117129918	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117129918C>A	uc004biq.3	-	5	1768	c.1633G>T	c.(1633-1635)GGG>TGG	p.G545W	AKNA_uc004bio.3_Missense_Mutation_p.G5W|AKNA_uc004bip.3_Missense_Mutation_p.G464W|AKNA_uc004bir.3_Missense_Mutation_p.G545W|AKNA_uc004bis.3_Missense_Mutation_p.G545W|AKNA_uc010mve.2_Missense_Mutation_p.G426W|AKNA_uc004biu.1_Missense_Mutation_p.G286W|AKNA_uc004biv.1_Missense_Mutation_p.G545W	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
DFNB31	25861	broad.mit.edu	37	9	117186606	117186606	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117186606C>T	uc004biz.3	-						DFNB31_uc004bix.2_Intron|DFNB31_uc004biy.3_Intron|DFNB31_uc004bja.3_Intron	NM_015404	NP_056219			CASK-interacting protein CIP98 isoform 1						inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
DFNB31	25861	broad.mit.edu	37	9	117186646	117186646	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117186646C>T	uc004biz.3	-	6	2033	c.1384G>A	c.(1384-1386)GCC>ACC	p.A462T	DFNB31_uc004bix.2_Missense_Mutation_p.A111T|DFNB31_uc004biy.3_Missense_Mutation_p.A79T|DFNB31_uc004bja.3_Missense_Mutation_p.A462T	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	462					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
DFNB31	25861	broad.mit.edu	37	9	117266884	117266884	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117266884G>A	uc004biz.3	-	1	847	c.198C>T	c.(196-198)CAC>CAT	p.H66H	DFNB31_uc004biy.3_5'Flank|DFNB31_uc004bja.3_Silent_p.H66H|DFNB31_uc004bjb.2_Silent_p.H66H	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	66					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
TNC	3371	broad.mit.edu	37	9	117826299	117826299	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117826299T>C	uc004bjj.3	-	12	3898	c.3536A>G	c.(3535-3537)GAT>GGT	p.D1179G	TNC_uc010mvf.2_Missense_Mutation_p.D1179G	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1179	Fibronectin type-III 7.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7																		---	---	---	---
TNC	3371	broad.mit.edu	37	9	117853152	117853152	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117853152A>G	uc004bjj.3	-	2	508	c.146T>C	c.(145-147)GTG>GCG	p.V49A	TNC_uc010mvf.2_Missense_Mutation_p.V49A	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	49					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7																		---	---	---	---
PAPPA	5069	broad.mit.edu	37	9	118950133	118950133	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:118950133C>T	uc004bjn.2	+	2	1497	c.1116C>T	c.(1114-1116)CGC>CGT	p.R372R	PAPPA_uc011lxp.1_Silent_p.R165R|PAPPA_uc011lxq.1_Silent_p.R165R	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	372	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9																		---	---	---	---
PAPPA	5069	broad.mit.edu	37	9	118974132	118974132	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:118974132T>C	uc004bjn.2	+	4	2220	c.1839T>C	c.(1837-1839)GGT>GGC	p.G613G	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	613					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9																		---	---	---	---
ASTN2	23245	broad.mit.edu	37	9	119204810	119204810	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:119204810T>C	uc004bjs.1	-	21	3621	c.3520A>G	c.(3520-3522)ACA>GCA	p.T1174A	ASTN2_uc004bjr.1_Missense_Mutation_p.T1170A|ASTN2_uc004bjt.1_Missense_Mutation_p.T1123A|ASTN2_uc004bjp.1_Missense_Mutation_p.T267A|ASTN2_uc004bjq.1_Missense_Mutation_p.T226A|ASTN2_uc011lxr.1_Missense_Mutation_p.T226A|ASTN2_uc011lxs.1_Missense_Mutation_p.T226A|ASTN2_uc011lxt.1_Missense_Mutation_p.T226A|ASTN2_uc004bjo.1_Translation_Start_Site	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1174	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9																		---	---	---	---
DBC1	1620	broad.mit.edu	37	9	122011371	122011371	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:122011371G>A	uc004bkc.2	-	3	732	c.276C>T	c.(274-276)CGC>CGT	p.R92R	DBC1_uc004bkd.2_Silent_p.R92R	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	92	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8																		---	---	---	---
C5	727	broad.mit.edu	37	9	123737152	123737152	+	Missense_Mutation	SNP	G	A	A	rs141543606	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123737152G>A	uc004bkv.2	-	30	3952	c.3922C>T	c.(3922-3924)CGC>TGC	p.R1308C		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1308					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)													---	---	---	---
DAB2IP	153090	broad.mit.edu	37	9	124543794	124543794	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124543794G>A	uc004bln.2	+	15	3351	c.3282G>A	c.(3280-3282)GCG>GCA	p.A1094A	DAB2IP_uc004blo.2_Silent_p.A998A|DAB2IP_uc004blp.2_Silent_p.A527A	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	1122	Potential.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TTLL11	158135	broad.mit.edu	37	9	124751996	124751996	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124751996T>C	uc004blt.1	-	4	1205	c.1017A>G	c.(1015-1017)AAA>AAG	p.K339K	TTLL11_uc011lyl.1_Silent_p.K339K|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Silent_p.K16K|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	339	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0																		---	---	---	---
TTLL11	158135	broad.mit.edu	37	9	124801573	124801573	+	Silent	SNP	G	A	A	rs116781476	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124801573G>A	uc004blt.1	-	2	995	c.807C>T	c.(805-807)TCC>TCT	p.S269S	TTLL11_uc011lyl.1_Silent_p.S269S|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_5'UTR|TTLL11_uc004blu.1_Silent_p.S269S	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	269	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0																		---	---	---	---
NDUFA8	4702	broad.mit.edu	37	9	124914655	124914655	+	Silent	SNP	C	T	T	rs117079538	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124914655C>T	uc004blv.2	-	2	226	c.84G>A	c.(82-84)GCG>GCA	p.A28A		NM_014222	NP_055037	P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	28					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1					NADH(DB00157)													---	---	---	---
MRRF	92399	broad.mit.edu	37	9	125033202	125033202	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125033202T>C	uc004bmb.2	+	2	147	c.32T>C	c.(31-33)GTC>GCC	p.V11A	MRRF_uc004bmc.2_Missense_Mutation_p.V11A|MRRF_uc011lyq.1_Missense_Mutation_p.V32A|MRRF_uc010mvz.1_RNA|MRRF_uc010mwa.2_Missense_Mutation_p.V11A|MRRF_uc011lyr.1_Missense_Mutation_p.V11A|MRRF_uc004bmd.2_Missense_Mutation_p.V11A|MRRF_uc004bme.2_RNA	NM_138777	NP_620132	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor isoform	11					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3																		---	---	---	---
ZBTB6	10773	broad.mit.edu	37	9	125673881	125673881	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125673881A>G	uc004bnh.2	-	2	560	c.471T>C	c.(469-471)TCT>TCC	p.S157S		NM_006626	NP_006617	Q15916	ZBTB6_HUMAN	zinc finger and BTB domain containing 6	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
CRB2	286204	broad.mit.edu	37	9	126133465	126133465	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:126133465G>A	uc004bnx.1	+	8	2136	c.2044G>A	c.(2044-2046)GCT>ACT	p.A682T	CRB2_uc004bnw.1_Missense_Mutation_p.A682T	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	682	Extracellular (Potential).|Laminin G-like 2.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1																		---	---	---	---
DENND1A	57706	broad.mit.edu	37	9	126212994	126212994	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:126212994A>C	uc004bnz.1	-	18	1567	c.1334T>G	c.(1333-1335)GTG>GGG	p.V445G	DENND1A_uc011lzl.1_Missense_Mutation_p.V220G|DENND1A_uc004bny.1_Missense_Mutation_p.V184G|DENND1A_uc011lzm.1_Missense_Mutation_p.V413G|DENND1A_uc004boa.1_Missense_Mutation_p.V445G|DENND1A_uc004bob.1_Missense_Mutation_p.V415G|DENND1A_uc004boc.2_Missense_Mutation_p.V413G	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	445						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2																		---	---	---	---
NR5A1	2516	broad.mit.edu	37	9	127245230	127245230	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127245230T>C	uc004boo.1	-	7	1380	c.1193A>G	c.(1192-1194)AAC>AGC	p.N398S		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	398	Important for dimerization.				cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0																		---	---	---	---
OLFML2A	169611	broad.mit.edu	37	9	127549284	127549284	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127549284A>G	uc004bov.2	+	2	234	c.121A>G	c.(121-123)ACC>GCC	p.T41A	OLFML2A_uc010mwr.1_Missense_Mutation_p.T41A	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	41											0																		---	---	---	---
OLFML2A	169611	broad.mit.edu	37	9	127549392	127549392	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127549392G>T	uc004bov.2	+	2	342	c.229G>T	c.(229-231)GTG>TTG	p.V77L	OLFML2A_uc010mwr.1_Missense_Mutation_p.V77L	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	77											0																		---	---	---	---
ANGPTL2	23452	broad.mit.edu	37	9	129870558	129870558	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:129870558G>A	uc004bqr.1	-	2	953	c.453C>T	c.(451-453)AAC>AAT	p.N151N	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Intron	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	151					multicellular organismal development|signal transduction	extracellular space	receptor binding				0																		---	---	---	---
GARNL3	84253	broad.mit.edu	37	9	130100385	130100385	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130100385A>G	uc011mae.1	+						GARNL3_uc011mad.1_Intron|GARNL3_uc004bqt.1_Intron	NM_032293	NP_115669			GTPase activating Rap/RanGAP domain-like 3						regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
ZNF79	7633	broad.mit.edu	37	9	130207103	130207103	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130207103A>G	uc004bqw.3	+	5	1538	c.1124A>G	c.(1123-1125)AAC>AGC	p.N375S	ZNF79_uc011maf.1_Missense_Mutation_p.N351S|ZNF79_uc011mag.1_Missense_Mutation_p.N351S	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	375	C2H2-type 7.			Missing (in Ref. 4; CAA46339).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
STXBP1	6812	broad.mit.edu	37	9	130416038	130416038	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130416038C>T	uc004brl.2	+	3	329	c.132C>T	c.(130-132)TGC>TGT	p.C44C	STXBP1_uc004brk.2_Silent_p.C44C	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	44					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1																		---	---	---	---
PTRH1	138428	broad.mit.edu	37	9	130476402	130476402	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130476402G>T	uc004bro.2	-	5	640	c.622C>A	c.(622-624)CAG>AAG	p.Q208K	PTRH1_uc004brm.2_Intron|PTRH1_uc010mxm.2_3'UTR|PTRH1_uc011mah.1_Missense_Mutation_p.Q221K|TTC16_uc004brq.1_5'Flank|TTC16_uc011mai.1_5'Flank|TTC16_uc004brr.1_5'Flank	NM_001002913	NP_001002913	Q86Y79	PTH_HUMAN	peptidyl-tRNA hydrolase 1 homolog	208					translation		aminoacyl-tRNA hydrolase activity|protein binding				0																		---	---	---	---
SH2D3C	10044	broad.mit.edu	37	9	130502658	130502658	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130502658C>T	uc004bsc.2	-						SH2D3C_uc010mxo.2_Intron|SH2D3C_uc004bry.2_Intron|SH2D3C_uc004brz.3_Intron|SH2D3C_uc011mak.1_Intron|SH2D3C_uc004bsa.2_Intron|SH2D3C_uc004bsb.2_Intron	NM_170600	NP_733745			SH2 domain containing 3C isoform a						JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1																		---	---	---	---
PIP5KL1	138429	broad.mit.edu	37	9	130687442	130687442	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130687442T>C	uc011mao.1	-	9	906	c.861A>G	c.(859-861)CAA>CAG	p.Q287Q	PIP5KL1_uc004bsu.2_Silent_p.Q84Q	NM_001135219	NP_001128691	Q5T9C9	PI5L1_HUMAN	phosphatidylinositol-4-phosphate 5-kinase-like 1	287	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			lung(1)|kidney(1)	2																		---	---	---	---
SLC25A25	114789	broad.mit.edu	37	9	130868031	130868031	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130868031C>T	uc004bte.2	+	6	698	c.669C>T	c.(667-669)AAC>AAT	p.N223N	SLC25A25_uc004btb.2_Silent_p.N257N|SLC25A25_uc004btc.2_Silent_p.N243N|SLC25A25_uc004btd.2_Silent_p.N255N|SLC25A25_uc004btf.2_Silent_p.N120N	NM_052901	NP_443133	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform a	223	Solcar 1.|Mitochondrial matrix (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0																		---	---	---	---
CIZ1	25792	broad.mit.edu	37	9	130941627	130941627	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130941627T>A	uc004btt.2	-	8	1022	c.859A>T	c.(859-861)ATG>TTG	p.M287L	CIZ1_uc004btr.2_Missense_Mutation_p.M287L|CIZ1_uc004bts.2_Missense_Mutation_p.M258L|CIZ1_uc011maq.1_Missense_Mutation_p.M282L|CIZ1_uc004btu.2_Missense_Mutation_p.M263L|CIZ1_uc011mar.1_Missense_Mutation_p.M186L|CIZ1_uc011mas.1_Missense_Mutation_p.M317L|CIZ1_uc004btw.2_Missense_Mutation_p.M287L|CIZ1_uc004btv.2_Missense_Mutation_p.M287L|CIZ1_uc004btx.2_Missense_Mutation_p.M263L	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	287	Gln-rich.					nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
GOLGA2	2801	broad.mit.edu	37	9	131021357	131021357	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131021357C>T	uc011maw.1	-	20	2034	c.2021G>A	c.(2020-2022)CGC>CAC	p.R674H	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004buh.2_Missense_Mutation_p.R147H	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	674	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1																		---	---	---	---
COQ4	51117	broad.mit.edu	37	9	131087459	131087459	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131087459C>T	uc004bur.3	+	3	587	c.240C>T	c.(238-240)CGC>CGT	p.R80R	TRUB2_uc004buq.1_5'Flank|COQ4_uc011max.1_Silent_p.R80R|COQ4_uc004bus.2_Silent_p.R56R|COQ4_uc010mxy.2_Silent_p.R56R	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	80					ubiquinone biosynthetic process	mitochondrial inner membrane					0																		---	---	---	---
PKN3	29941	broad.mit.edu	37	9	131469074	131469074	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131469074G>A	uc004bvw.2	+	4	887	c.494G>A	c.(493-495)AGC>AAC	p.S165N	PKN3_uc010myh.2_Missense_Mutation_p.S165N|PKN3_uc011mbk.1_5'UTR	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	165	REM 2.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4																		---	---	---	---
ENDOG	2021	broad.mit.edu	37	9	131584738	131584738	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131584738T>C	uc004bwc.2	+	3	928	c.743T>C	c.(742-744)GTG>GCG	p.V248A	C9orf114_uc004bwd.2_3'UTR|C9orf114_uc004bwe.2_3'UTR|C9orf114_uc010mym.2_RNA	NM_004435	NP_004426	Q14249	NUCG_HUMAN	endonuclease G precursor	248						mitochondrion	endonuclease activity|metal ion binding|nucleic acid binding				0																		---	---	---	---
PHYHD1	254295	broad.mit.edu	37	9	131703842	131703842	+	Silent	SNP	G	A	A	rs147819781	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131703842G>A	uc004bwo.2	+	12	1755	c.822G>A	c.(820-822)CCG>CCA	p.P274P	PHYHD1_uc004bwn.2_Missense_Mutation_p.R267Q|PHYHD1_uc004bwm.2_RNA|PHYHD1_uc004bwp.2_Silent_p.P253P|NUP188_uc004bwq.1_Silent_p.P10P	NM_001100876	NP_001094346	Q5SRE7	PHYD1_HUMAN	phytanoyl-CoA dioxygenase domain containing 1	274							metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---
DOLK	22845	broad.mit.edu	37	9	131709341	131709341	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131709341A>G	uc004bwr.2	-	1	672	c.242T>C	c.(241-243)CTA>CCA	p.L81P	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	81	Helical; (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0																		---	---	---	---
NUP188	23511	broad.mit.edu	37	9	131730780	131730780	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131730780T>C	uc004bws.1	+							NM_015354	NP_056169			nucleoporin 188kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7																		---	---	---	---
NUP188	23511	broad.mit.edu	37	9	131767594	131767594	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131767594G>A	uc004bws.1	+	40	4544	c.4522G>A	c.(4522-4524)GAT>AAT	p.D1508N		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1508					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7																		---	---	---	---
FAM73B	84895	broad.mit.edu	37	9	131832578	131832578	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131832578A>G	uc004bxa.2	+	16	1814	c.1628A>G	c.(1627-1629)TAC>TGC	p.Y543C	FAM73B_uc004bwy.2_RNA|FAM73B_uc004bwz.2_RNA|FAM73B_uc004bxb.2_Missense_Mutation_p.Y119C	NM_032809	NP_116198	Q7L4E1	FA73B_HUMAN	hypothetical protein LOC84895	543						integral to membrane				skin(1)	1																		---	---	---	---
CRAT	1384	broad.mit.edu	37	9	131857756	131857756	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131857756C>T	uc004bxh.2	-	14	2083	c.1801G>A	c.(1801-1803)GCC>ACC	p.A601T	CRAT_uc004bxg.2_Missense_Mutation_p.A580T|CRAT_uc004bxk.3_Missense_Mutation_p.A580T	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	601					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)													---	---	---	---
C9orf106	414318	broad.mit.edu	37	9	132084350	132084350	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132084350T>C	uc004bxs.2	+	2	311	c.258T>C	c.(256-258)CTT>CTC	p.L86L		NM_001012715	NP_001012733	Q8NAJ2	CI106_HUMAN	hypothetical protein LOC414318	86											0		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)																---	---	---	---
USP20	10868	broad.mit.edu	37	9	132620767	132620767	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132620767G>A	uc004bys.2	+	6	431	c.220G>A	c.(220-222)GTG>ATG	p.V74M	USP20_uc004byr.2_Missense_Mutation_p.V74M|USP20_uc004byt.1_Missense_Mutation_p.V74M	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	74	UBP-type.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)																---	---	---	---
USP20	10868	broad.mit.edu	37	9	132630544	132630544	+	Silent	SNP	G	A	A	rs35868738		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132630544G>A	uc004bys.2	+	11	1162	c.951G>A	c.(949-951)GCG>GCA	p.A317A	USP20_uc004byr.2_Silent_p.A317A|USP20_uc004byt.1_Silent_p.A317A	NM_001110303	NP_001103773	Q9Y2K6	UBP20_HUMAN	ubiquitin specific protease 20	317					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			lung(1)|breast(1)	2		Ovarian(14;0.00556)																---	---	---	---
FNBP1	23048	broad.mit.edu	37	9	132687349	132687349	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132687349G>A	uc004byw.1	-	9	1096	c.877C>T	c.(877-879)CGC>TGC	p.R293C	FNBP1_uc011mbv.1_Missense_Mutation_p.R293C|FNBP1_uc011mbw.1_Missense_Mutation_p.R293C|FNBP1_uc004bza.2_Missense_Mutation_p.R293C|FNBP1_uc004byz.1_Missense_Mutation_p.R293C|FNBP1_uc004byx.1_Missense_Mutation_p.R214C|FNBP1_uc004byy.1_Missense_Mutation_p.R214C	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	293	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)				T	MLL	AML								---	---	---	---
ASS1	445	broad.mit.edu	37	9	133342148	133342148	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133342148C>T	uc004bzm.2	+	7	813	c.457C>T	c.(457-459)CGG>TGG	p.R153W	ASS1_uc004bzn.2_Missense_Mutation_p.R153W|ASS1_uc010mza.2_Missense_Mutation_p.R229W|ASS1_uc004bzo.2_Missense_Mutation_p.R134W|ASS1_uc010mzb.2_Missense_Mutation_p.R191W|ASS1_uc004bzp.2_Missense_Mutation_p.R153W|ASS1_uc010mzc.2_Missense_Mutation_p.R153W	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	153					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)													---	---	---	---
FUBP3	8939	broad.mit.edu	37	9	133491810	133491810	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:133491810T>C	uc004bzr.1	+	7	581	c.473T>C	c.(472-474)ATA>ACA	p.I158T	FUBP3_uc010mzd.1_Missense_Mutation_p.I98T|FUBP3_uc004bzs.1_Missense_Mutation_p.I71T	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	158					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)														---	---	---	---
NUP214	8021	broad.mit.edu	37	9	134073745	134073745	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134073745T>C	uc004cag.2	+	29	4975	c.4864T>C	c.(4864-4866)TCC>CCC	p.S1622P	NUP214_uc004cah.2_Missense_Mutation_p.S1612P|NUP214_uc004cai.2_Missense_Mutation_p.S1052P|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S448P|NUP214_uc011mcf.1_Missense_Mutation_p.S399P|NUP214_uc010mzh.1_Missense_Mutation_p.S136P|NUP214_uc010mzi.1_Missense_Mutation_p.S136P	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1622	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)				T	DEK|SET|ABL1	AML|T-ALL								---	---	---	---
FAM78A	286336	broad.mit.edu	37	9	134151238	134151238	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134151238A>G	uc004cak.2	-							NM_033387	NP_203745			hypothetical protein LOC286336											ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)														---	---	---	---
POMT1	10585	broad.mit.edu	37	9	134379614	134379614	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134379614A>T	uc004cav.2	+	2	211	c.9A>T	c.(7-9)GGA>GGT	p.G3G	POMT1_uc011mci.1_Silent_p.G3G|POMT1_uc004cax.2_Silent_p.G3G|POMT1_uc011mcj.1_Intron|POMT1_uc004cau.2_Silent_p.G3G|POMT1_uc004caw.2_Intron|POMT1_uc011mck.1_Intron|POMT1_uc011mcl.1_Intron|POMT1_uc011mcm.1_Silent_p.G3G	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	3					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)												OREG0019563	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
UCK1	83549	broad.mit.edu	37	9	134405877	134405877	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134405877A>T	uc004cay.2	-	2	365	c.264T>A	c.(262-264)CAT>CAA	p.H88Q	UCK1_uc010mzk.2_Missense_Mutation_p.H79Q|UCK1_uc004cba.2_Missense_Mutation_p.H88Q|UCK1_uc004caz.2_RNA	NM_031432	NP_113620	Q9HA47	UCK1_HUMAN	uridine-cytidine kinase 1 isoform a	88					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;2.34e-05)|Epithelial(140;0.000219)														---	---	---	---
NTNG2	84628	broad.mit.edu	37	9	135042324	135042324	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135042324T>C	uc004cbh.2	+	2	882	c.106T>C	c.(106-108)TTC>CTC	p.F36L		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	36	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)														---	---	---	---
SETX	23064	broad.mit.edu	37	9	135152521	135152521	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135152521T>C	uc004cbk.2	-	22	7044	c.6861A>G	c.(6859-6861)CGA>CGG	p.R2287R	SETX_uc004cbj.2_Silent_p.R1906R|SETX_uc010mzt.2_Silent_p.R1906R	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2287					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)														---	---	---	---
SETX	23064	broad.mit.edu	37	9	135211677	135211677	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135211677A>G	uc004cbk.2	-							NM_015046	NP_055861			senataxin						cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)														---	---	---	---
C9orf98	158067	broad.mit.edu	37	9	135742312	135742312	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135742312G>A	uc004cbu.1	-	3	754	c.198C>T	c.(196-198)CCC>CCT	p.P66P	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_5'UTR	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	66						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)														---	---	---	---
CEL	1056	broad.mit.edu	37	9	135939927	135939927	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135939927A>G	uc010naa.1	+	2	228	c.212A>G	c.(211-213)CAT>CGT	p.H71R		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	68	Heparin-binding.				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)														---	---	---	---
CEL	1056	broad.mit.edu	37	9	135945877	135945877	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135945877C>T	uc010naa.1	+	10	1341	c.1325C>T	c.(1324-1326)TCC>TTC	p.S442F		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	439					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)														---	---	---	---
RALGDS	5900	broad.mit.edu	37	9	135985812	135985812	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135985812G>A	uc004cco.2	-	3	379	c.359C>T	c.(358-360)ACG>ATG	p.T120M	RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.T120M|RALGDS_uc004ccr.2_Missense_Mutation_p.T119M|RALGDS_uc011mcv.1_Missense_Mutation_p.T103M|RALGDS_uc004ccs.2_Missense_Mutation_p.T65M|RALGDS_uc011mcw.1_Missense_Mutation_p.T191M|RALGDS_uc004ccv.1_5'Flank|RALGDS_uc004ccu.1_5'Flank	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	120	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)				T	CIITA	PMBL|Hodgkin Lymphona|								---	---	---	---
REXO4	57109	broad.mit.edu	37	9	136279819	136279819	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136279819T>C	uc004cdm.2	-	2	738	c.538A>G	c.(538-540)AAA>GAA	p.K180E	ADAMTS13_uc004cdp.3_Intron|REXO4_uc011mde.1_Missense_Mutation_p.K43E|REXO4_uc011mdf.1_Missense_Mutation_p.K43E|REXO4_uc004cdn.2_Intron|REXO4_uc004cdo.2_Silent_p.G120G	NM_020385	NP_065118	Q9GZR2	REXO4_HUMAN	XPMC2 prevents mitotic catastrophe 2 homolog	180						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)														---	---	---	---
ADAMTS13	11093	broad.mit.edu	37	9	136304555	136304555	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136304555T>C	uc004cdv.3	+	15	2218	c.1774T>C	c.(1774-1776)TTC>CTC	p.F592L	ADAMTS13_uc004cdp.3_5'UTR|ADAMTS13_uc004cdt.1_Missense_Mutation_p.F592L|ADAMTS13_uc004cdu.1_Missense_Mutation_p.F561L|ADAMTS13_uc004cdw.3_Missense_Mutation_p.F592L|ADAMTS13_uc004cdx.3_Missense_Mutation_p.F561L|ADAMTS13_uc004cdy.1_RNA|ADAMTS13_uc004cdz.3_Missense_Mutation_p.F262L|ADAMTS13_uc004cds.1_Missense_Mutation_p.F117L|ADAMTS13_uc004cdr.1_RNA	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	592	Spacer.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)														---	---	---	---
TMEM8C	389827	broad.mit.edu	37	9	136384051	136384051	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136384051T>C	uc011mdk.1	-	3	344	c.344A>G	c.(343-345)TAC>TGC	p.Y115C		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	115	Helical; (Potential).					integral to membrane					0																		---	---	---	---
VAV2	7410	broad.mit.edu	37	9	136629235	136629235	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136629235A>G	uc004ces.2	-						VAV2_uc004cer.2_Intron	NM_001134398	NP_001127870			vav 2 guanine nucleotide exchange factor isoform						angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)														---	---	---	---
VAV2	7410	broad.mit.edu	37	9	136641200	136641200	+	Silent	SNP	C	T	T	rs150295787		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136641200C>T	uc004ces.2	-	24	2014	c.1968G>A	c.(1966-1968)CCG>CCA	p.P656P	VAV2_uc004cer.2_Silent_p.P646P|VAV2_uc004cet.1_Silent_p.P195P	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	656					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)														---	---	---	---
VAV2	7410	broad.mit.edu	37	9	136674187	136674187	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136674187T>C	uc004ces.2	-	7	687	c.641A>G	c.(640-642)TAC>TGC	p.Y214C	VAV2_uc004cer.2_Missense_Mutation_p.Y209C	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	214	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)														---	---	---	---
BRD3	8019	broad.mit.edu	37	9	136917441	136917441	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136917441T>C	uc004cew.2	-	3	526	c.338A>G	c.(337-339)TAC>TGC	p.Y113C	BRD3_uc004cex.2_Missense_Mutation_p.Y113C	NM_007371	NP_031397	Q15059	BRD3_HUMAN	bromodomain containing protein 3	113	Bromo 1.					nucleus	protein binding		BRD3/C15orf55(3)	stomach(4)|midline_organs(3)|kidney(1)	8				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)				T	NUT|C15orf55	lethal midline carcinoma of young people								---	---	---	---
KIAA0649	9858	broad.mit.edu	37	9	138376588	138376588	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138376588T>C	uc004cfr.1	+	4	781	c.232T>C	c.(232-234)TGC>CGC	p.C78R		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	78						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)														---	---	---	---
LHX3	8022	broad.mit.edu	37	9	139092558	139092558	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139092558G>A	uc004cha.2	-	2	218	c.121C>T	c.(121-123)CGC>TGC	p.R41C	LHX3_uc004cgz.2_Missense_Mutation_p.R46C	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	41	LIM zinc-binding 1.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)														---	---	---	---
PMPCA	23203	broad.mit.edu	37	9	139313291	139313291	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139313291T>C	uc004chl.2	+	10	1126	c.1121T>C	c.(1120-1122)ATG>ACG	p.M374T	PMPCA_uc010nbl.2_Missense_Mutation_p.M274T|PMPCA_uc011mdz.1_Missense_Mutation_p.M243T|PMPCA_uc004chm.1_Missense_Mutation_p.M124T|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	374					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)														---	---	---	---
SEC16A	9919	broad.mit.edu	37	9	139370019	139370019	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139370019C>T	uc004chx.2	-	3	2358	c.2049G>A	c.(2047-2049)ACG>ACA	p.T683T	SEC16A_uc004chv.3_Silent_p.T310T|SEC16A_uc004chw.2_Silent_p.T683T|SEC16A_uc010nbn.2_Silent_p.T683T|SEC16A_uc010nbo.1_Silent_p.T683T	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	505					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)														---	---	---	---
SEC16A	9919	broad.mit.edu	37	9	139370931	139370931	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139370931T>C	uc004chx.2	-	3	1446	c.1137A>G	c.(1135-1137)GGA>GGG	p.G379G	SEC16A_uc004chv.3_Silent_p.G6G|SEC16A_uc004chw.2_Silent_p.G379G|SEC16A_uc010nbn.2_Silent_p.G379G|SEC16A_uc010nbo.1_Silent_p.G379G	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	201					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)														---	---	---	---
NOTCH1	4851	broad.mit.edu	37	9	139396368	139396368	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139396368A>G	uc004chz.2	-							NM_017617	NP_060087			notch1 preproprotein						aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)				T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			---	---	---	---
KIAA1984	84960	broad.mit.edu	37	9	139699251	139699251	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139699251G>A	uc004cjf.2	+	8	878	c.830G>A	c.(829-831)AGC>AAC	p.S277N	C9orf86_uc004cjm.2_5'Flank|C9orf86_uc004cjh.2_5'Flank|C9orf86_uc004cjj.1_5'Flank|C9orf86_uc004cjk.1_5'Flank|LOC100131193_uc004cjg.1_RNA	NM_001039374	NP_001034463	Q5T5S1	K1984_HUMAN	hypothetical protein LOC84960	277										ovary(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.33e-06)|Epithelial(140;0.000124)														---	---	---	---
MAMDC4	158056	broad.mit.edu	37	9	139752922	139752922	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139752922C>A	uc004cjs.2	+	22	2795	c.2745C>A	c.(2743-2745)AGC>AGA	p.S915R	MAMDC4_uc011mej.1_Missense_Mutation_p.S252R	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	994	Extracellular (Potential).|MAM 6.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)														---	---	---	---
MAMDC4	158056	broad.mit.edu	37	9	139752975	139752975	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139752975A>G	uc004cjs.2	+	22	2848	c.2798A>G	c.(2797-2799)GAC>GGC	p.D933G	MAMDC4_uc011mej.1_Missense_Mutation_p.D270G	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1012	Extracellular (Potential).|MAM 6.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)														---	---	---	---
TRAF2	7186	broad.mit.edu	37	9	139814796	139814796	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139814796C>T	uc010nbu.2	+	9	962	c.789C>T	c.(787-789)CAC>CAT	p.H263H	TRAF2_uc004cjv.2_Silent_p.H263H|TRAF2_uc011mek.1_Silent_p.H252H|TRAF2_uc010nbw.2_Silent_p.H238H	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	263				Missing (in Ref. 2; BAB70792).	activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)														---	---	---	---
ABCA2	20	broad.mit.edu	37	9	139911421	139911421	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139911421G>A	uc011mem.1	-	18	2854	c.2706C>T	c.(2704-2706)GAC>GAT	p.D902D	ABCA2_uc011mel.1_Silent_p.D903D|ABCA2_uc004ckl.1_Silent_p.D833D|ABCA2_uc004ckm.1_Silent_p.D933D|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	902	Helical; (Potential).				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
ABCA2	20	broad.mit.edu	37	9	139912270	139912270	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139912270A>G	uc011mem.1	-	15	2325	c.2177T>C	c.(2176-2178)ATC>ACC	p.I726T	ABCA2_uc011mel.1_Missense_Mutation_p.I727T|ABCA2_uc004ckl.1_Missense_Mutation_p.I657T|ABCA2_uc004ckm.1_Missense_Mutation_p.I757T|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	726					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
UAP1L1	91373	broad.mit.edu	37	9	139972986	139972986	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139972986C>A	uc010ncb.2	+	3	559	c.527C>A	c.(526-528)CCC>CAC	p.P176H	UAP1L1_uc004cla.3_Missense_Mutation_p.P53H	NM_207309	NP_997192	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like	176							nucleotidyltransferase activity			ovary(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)														---	---	---	---
NDOR1	27158	broad.mit.edu	37	9	140110800	140110800	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140110800C>T	uc004clw.2	+	14	1837	c.1726C>T	c.(1726-1728)CCG>TCG	p.P576S	NDOR1_uc004clx.2_Missense_Mutation_p.P585S|NDOR1_uc011mes.1_Missense_Mutation_p.P569S|NDOR1_uc004cly.2_3'UTR	NM_014434	NP_055249	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	576					cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
SLC34A3	142680	broad.mit.edu	37	9	140126242	140126242	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140126242A>G	uc004cmf.1	+						SLC34A3_uc004cmc.1_Intron|SLC34A3_uc004cmd.1_Intron|SLC34A3_uc011met.1_Intron	NM_080877	NP_543153			solute carrier family 34 (sodium phosphate),						cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
TUBB2C	10383	broad.mit.edu	37	9	140136267	140136267	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140136267A>G	uc004cmh.1	+	2	254	c.152A>G	c.(151-153)TAC>TGC	p.Y51C	TUBB2C_uc004cmg.1_5'UTR	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	51					'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
NOXA1	10811	broad.mit.edu	37	9	140328738	140328738	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140328738G>A	uc004cmv.2	+	14	1492	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.V460M|NOXA1_uc010nch.2_Missense_Mutation_p.V404M	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	453	SH3.		Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)														---	---	---	---
ENTPD8	377841	broad.mit.edu	37	9	140329696	140329696	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140329696A>C	uc004cmw.2	-	9	1440	c.1256T>G	c.(1255-1257)TTC>TGC	p.F419C	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.F382C	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	419	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)														---	---	---	---
ARRDC1	92714	broad.mit.edu	37	9	140508787	140508787	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140508787G>A	uc004cns.2	+	6	729	c.655G>A	c.(655-657)GTA>ATA	p.V219I	ARRDC1_uc004cnt.2_Missense_Mutation_p.V94I|ARRDC1_uc004cnu.2_RNA|ARRDC1_uc004cnv.2_Missense_Mutation_p.V199I|ARRDC1_uc004cnw.2_Missense_Mutation_p.V94I|ARRDC1_uc004cnp.1_Missense_Mutation_p.V219I|ARRDC1_uc004cnq.1_Missense_Mutation_p.V201I|ARRDC1_uc011mfb.1_Missense_Mutation_p.V94I|ARRDC1_uc004cnx.1_Missense_Mutation_p.V94I|ARRDC1_uc004cny.2_RNA	NM_152285	NP_689498	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	219											0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)														---	---	---	---
EHMT1	79813	broad.mit.edu	37	9	140685319	140685319	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140685319C>T	uc011mfc.1	+	16	2439	c.2402C>T	c.(2401-2403)ACC>ATC	p.T801I	EHMT1_uc004cob.1_Missense_Mutation_p.T770I	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	801	ANK 2.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)														---	---	---	---
CACNA1B	774	broad.mit.edu	37	9	140878582	140878582	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140878582C>T	uc004cog.2	+						CACNA1B_uc011mfd.1_Intron	NM_000718	NP_000709			calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)													---	---	---	---
CACNA1B	774	broad.mit.edu	37	9	140943773	140943773	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140943773T>C	uc004cog.2	+						CACNA1B_uc011mfd.1_Intron|CACNA1B_uc004coi.2_Intron	NM_000718	NP_000709			calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)													---	---	---	---
CACNA1B	774	broad.mit.edu	37	9	140968057	140968057	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140968057G>A	uc004cog.2	+	32	4936	c.4791_splice	c.e32+1	p.K1597_splice	CACNA1B_uc004coi.2_Splice_Site_p.K809_splice|CACNA1B_uc004cok.1_5'Flank|CACNA1B_uc010ncp.1_5'Flank	NM_000718	NP_000709			calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)													---	---	---	---
DIP2C	22982	broad.mit.edu	37	10	395363	395363	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:395363T>A	uc001ifp.2	-	25	3107	c.3017A>T	c.(3016-3018)CAG>CTG	p.Q1006L	DIP2C_uc009xhi.1_Missense_Mutation_p.Q392L	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1006						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)														---	---	---	---
ADARB2	105	broad.mit.edu	37	10	1232452	1232452	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:1232452T>C	uc009xhq.2	-						ADARB2_uc009xhp.2_Intron|ADARB2_uc001igl.3_Intron|ADARB2_uc001igm.3_Intron	NM_018702	NP_061172			adenosine deaminase, RNA-specific, B2						mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)														---	---	---	---
PITRM1	10531	broad.mit.edu	37	10	3199640	3199640	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3199640A>G	uc010qah.1	-	11	1270	c.1238T>C	c.(1237-1239)CTG>CCG	p.L413P	PITRM1_uc001igr.1_Missense_Mutation_p.L445P|PITRM1_uc001igt.1_Missense_Mutation_p.L445P|PITRM1_uc009xhv.1_Missense_Mutation_p.L10P|PITRM1_uc001igu.1_Missense_Mutation_p.L437P|PITRM1_uc010qai.1_Missense_Mutation_p.L416P|PITRM1_uc001igw.1_Missense_Mutation_p.L445P			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	413					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1																		---	---	---	---
KLF6	1316	broad.mit.edu	37	10	3821740	3821740	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:3821740C>T	uc001iha.2	-	4	1110	c.843G>A	c.(841-843)AGG>AGA	p.R281R	KLF6_uc010qaj.1_3'UTR|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Silent_p.R239R	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	281	C2H2-type 3.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)														---	---	---	---
AKR1E2	83592	broad.mit.edu	37	10	4875661	4875661	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:4875661A>G	uc001ihi.2	+						AKR1E2_uc001ihl.1_Intron|AKR1E2_uc010qam.1_Intron|AKR1E2_uc001ihh.1_Intron|AKR1E2_uc009xhw.2_Intron|AKR1E2_uc001ihj.2_Intron|AKR1E2_uc001ihk.2_Intron	NM_001040177	NP_001035267			aldo-keto reductase family 1, member E2							cytoplasm	1,5-anhydro-D-fructose reductase activity				0																		---	---	---	---
NET1	10276	broad.mit.edu	37	10	5498073	5498073	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5498073A>G	uc001iia.2	+	11	1359	c.1221A>G	c.(1219-1221)CAA>CAG	p.Q407Q	NET1_uc010qar.1_Silent_p.Q226Q|NET1_uc001iib.2_Silent_p.Q353Q|NET1_uc010qas.1_Silent_p.Q226Q	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	407	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1																		---	---	---	---
CALML5	51806	broad.mit.edu	37	10	5541219	5541219	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5541219G>A	uc001iic.2	-	1	315	c.183C>T	c.(181-183)GAC>GAT	p.D61D		NM_017422	NP_059118	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	61	EF-hand 2.|2 (Potential).				epidermis development|signal transduction		calcium ion binding|protein binding				0																		---	---	---	---
CALML3	810	broad.mit.edu	37	10	5567441	5567441	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5567441G>A	uc001iie.1	+	1	518	c.393G>A	c.(391-393)ACG>ACA	p.T131T	uc001iid.1_5'Flank	NM_005185	NP_005176	P27482	CALL3_HUMAN	calmodulin-like 3	131	4.|EF-hand 4.						calcium ion binding				0																		---	---	---	---
PRKCQ	5588	broad.mit.edu	37	10	6531351	6531351	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:6531351T>C	uc001ijj.1	-						PRKCQ_uc009xim.1_Intron|PRKCQ_uc001iji.1_Intron|PRKCQ_uc009xin.1_Intron|PRKCQ_uc010qax.1_Intron	NM_006257	NP_006248			protein kinase C, theta						axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6																		---	---	---	---
ITIH5	80760	broad.mit.edu	37	10	7683905	7683905	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7683905A>G	uc001ijq.2	-	3	363	c.284T>C	c.(283-285)ATC>ACC	p.I95T	ITIH5_uc001ijr.1_Missense_Mutation_p.I95T	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	95	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4																		---	---	---	---
TAF3	83860	broad.mit.edu	37	10	7866512	7866512	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7866512C>T	uc010qbd.1	+	2	398	c.398C>T	c.(397-399)TCT>TTT	p.S133F		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	133					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TAF3	83860	broad.mit.edu	37	10	8006770	8006770	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:8006770A>G	uc010qbd.1	+	3	1297	c.1297A>G	c.(1297-1299)ACT>GCT	p.T433A		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	433					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
TAF3	83860	broad.mit.edu	37	10	8007187	8007187	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:8007187A>G	uc010qbd.1	+	3	1714	c.1714A>G	c.(1714-1716)ACA>GCA	p.T572A		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	572	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
NMT2	9397	broad.mit.edu	37	10	15154898	15154898	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15154898T>C	uc001inz.1	-	10	1319	c.1235A>G	c.(1234-1236)CAC>CGC	p.H412R	NMT2_uc001ioa.1_Missense_Mutation_p.H399R|NMT2_uc009xjo.1_Missense_Mutation_p.H412R|NMT2_uc010qbz.1_Missense_Mutation_p.H224R	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	412					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1																		---	---	---	---
FAM171A1	221061	broad.mit.edu	37	10	15255063	15255063	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15255063C>T	uc001iob.2	-	8	2531	c.2524G>A	c.(2524-2526)GCC>ACC	p.A842T		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	842	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	16994323	16994323	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:16994323A>G	uc001ioo.2	-	33	4973	c.4921T>C	c.(4921-4923)TAT>CAT	p.Y1641H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1641	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
CACNB2	783	broad.mit.edu	37	10	18823131	18823131	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:18823131T>C	uc001ipr.2	+	11	1241	c.1181T>C	c.(1180-1182)GTA>GCA	p.V394A	CACNB2_uc009xjz.1_Intron|CACNB2_uc001ips.2_Missense_Mutation_p.V370A|CACNB2_uc001ipt.2_Missense_Mutation_p.V356A|CACNB2_uc001ipu.2_Missense_Mutation_p.V366A|CACNB2_uc001ipv.2_Missense_Mutation_p.V342A|CACNB2_uc009xka.1_Missense_Mutation_p.V328A|CACNB2_uc001ipw.2_Missense_Mutation_p.V301A|CACNB2_uc001ipx.2_Missense_Mutation_p.V339A|CACNB2_uc001ipz.2_Missense_Mutation_p.V316A|CACNB2_uc001ipy.2_Missense_Mutation_p.V340A|CACNB2_uc010qco.1_Missense_Mutation_p.V308A|CACNB2_uc001iqa.2_Missense_Mutation_p.V346A|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	394					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)													---	---	---	---
C10orf113	387638	broad.mit.edu	37	10	21414839	21414839	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21414839T>C	uc001iqm.2	-	2	371	c.351A>G	c.(349-351)ATA>ATG	p.I117M	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	127										ovary(3)|pancreas(1)	4																		---	---	---	---
PIP4K2A	5305	broad.mit.edu	37	10	22896941	22896941	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22896941G>A	uc001irl.3	-	3	502	c.254C>T	c.(253-255)CCG>CTG	p.P85L		NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	85	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2																		---	---	---	---
PIP4K2A	5305	broad.mit.edu	37	10	23003192	23003192	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:23003192G>A	uc001irl.3	-	1	312	c.64C>T	c.(64-66)CAC>TAC	p.H22Y		NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	22							1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2																		---	---	---	---
THNSL1	79896	broad.mit.edu	37	10	25314110	25314110	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25314110T>C	uc001isi.3	+	3	2287	c.1958T>C	c.(1957-1959)GTG>GCG	p.V653A	ENKUR_uc001ish.1_Intron	NM_024838	NP_079114	Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1	653					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			pancreas(1)	1					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25861658	25861658	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25861658T>C	uc001isj.2	+	7	1655	c.1595T>C	c.(1594-1596)GTA>GCA	p.V532A		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	532	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25887184	25887184	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25887184T>C	uc001isj.2	+	11	2689	c.2629T>C	c.(2629-2631)TGC>CGC	p.C877R	GPR158_uc001isk.2_Missense_Mutation_p.C252R	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	877	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
GPR158	57512	broad.mit.edu	37	10	25887641	25887641	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:25887641T>C	uc001isj.2	+	11	3146	c.3086T>C	c.(3085-3087)GTA>GCA	p.V1029A	GPR158_uc001isk.2_Missense_Mutation_p.V404A	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1029	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8																		---	---	---	---
ANKRD26	22852	broad.mit.edu	37	10	27306695	27306695	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27306695C>G	uc001ith.2	-	30	4411	c.4239G>C	c.(4237-4239)GAG>GAC	p.E1413D	ANKRD26_uc001itg.2_Missense_Mutation_p.E1100D|ANKRD26_uc009xku.1_Missense_Mutation_p.E1414D	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1413	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4																		---	---	---	---
ANKRD26	22852	broad.mit.edu	37	10	27311484	27311484	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27311484T>C	uc001ith.2	-						ANKRD26_uc001itg.2_Intron|ANKRD26_uc009xku.1_Intron	NM_014915	NP_055730			ankyrin repeat domain 26							centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4																		---	---	---	---
ANKRD26	22852	broad.mit.edu	37	10	27382687	27382687	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27382687A>G	uc001ith.2	-	2	456	c.284T>C	c.(283-285)GTA>GCA	p.V95A	ANKRD26_uc009xku.1_Missense_Mutation_p.V95A	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	95	ANK 2.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4																		---	---	---	---
MASTL	84930	broad.mit.edu	37	10	27454351	27454351	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27454351G>A	uc001itm.2	+	6	1333	c.694G>A	c.(694-696)GCA>ACA	p.A232T	MASTL_uc001itl.2_Missense_Mutation_p.A232T|MASTL_uc009xkw.1_Missense_Mutation_p.A232T|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	232	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
RAB18	22931	broad.mit.edu	37	10	27798869	27798869	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:27798869T>C	uc001itv.2	+						RAB18_uc001itw.2_Intron|RAB18_uc010qdq.1_Intron|RAB18_uc010qdr.1_Intron	NM_021252	NP_067075			RAB18, member RAS oncogene family						endocytosis|protein transport|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|GTPase activity|transcription factor binding				0																		---	---	---	---
MPP7	143098	broad.mit.edu	37	10	28358700	28358700	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28358700C>T	uc001iua.1	-	15	1608	c.1204_splice	c.e15+1	p.H402_splice	MPP7_uc009xkz.1_Splice_Site|MPP7_uc001iub.1_Splice_Site_p.H402_splice|MPP7_uc009xla.2_Splice_Site_p.H402_splice|MPP7_uc010qdv.1_Splice_Site	NM_173496	NP_775767			palmitoylated membrane protein 7						establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1																		---	---	---	---
WAC	51322	broad.mit.edu	37	10	28897190	28897190	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28897190C>T	uc001iuf.2	+	8	1080	c.995C>T	c.(994-996)CCC>CTC	p.P332L	WAC_uc001iud.2_Missense_Mutation_p.P287L|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Missense_Mutation_p.P287L|WAC_uc001iug.2_Missense_Mutation_p.P229L|WAC_uc001iuh.2_Missense_Mutation_p.P287L	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	332					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
KIAA1462	57608	broad.mit.edu	37	10	30316194	30316194	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:30316194A>G	uc001iux.2	-	2	2942	c.2883T>C	c.(2881-2883)GTT>GTC	p.V961V	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.V823V|KIAA1462_uc009xle.1_Silent_p.V961V	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	961										ovary(4)	4																		---	---	---	---
KIAA1462	57608	broad.mit.edu	37	10	30317740	30317740	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:30317740A>T	uc001iux.2	-	2	1396	c.1337T>A	c.(1336-1338)ATA>AAA	p.I446K	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.I308K|KIAA1462_uc009xle.1_Missense_Mutation_p.I446K	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	446										ovary(4)	4																		---	---	---	---
MAP3K8	1326	broad.mit.edu	37	10	30749625	30749625	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:30749625T>C	uc001ivi.1	+						MAP3K8_uc009xlf.1_Intron|MAP3K8_uc001ivj.1_Intron	NM_005204	NP_005195			mitogen-activated protein kinase kinase kinase						cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)																---	---	---	---
ZNF438	220929	broad.mit.edu	37	10	31134202	31134202	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:31134202T>C	uc010qdz.1	-	8	2610	c.2175A>G	c.(2173-2175)AGA>AGG	p.R725R	ZNF438_uc001ivn.2_Silent_p.R676R|ZNF438_uc010qdy.1_Silent_p.R715R|ZNF438_uc001ivo.3_Silent_p.R289R|ZNF438_uc009xlg.2_Silent_p.R725R|ZNF438_uc001ivp.3_Silent_p.R715R|ZNF438_uc010qea.1_Silent_p.R725R|ZNF438_uc010qeb.1_Silent_p.R725R	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)																---	---	---	---
EPC1	80314	broad.mit.edu	37	10	32575755	32575755	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32575755T>C	uc001iwg.1	-	9	1528	c.1258A>G	c.(1258-1260)ACT>GCT	p.T420A	EPC1_uc001iwi.3_Missense_Mutation_p.T370A|EPC1_uc009xlt.2_Missense_Mutation_p.T370A|EPC1_uc001iwh.1_Missense_Mutation_p.T420A	NM_025209	NP_079485	Q9H2F5	EPC1_HUMAN	enhancer of polycomb 1	420					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				ovary(3)|central_nervous_system(1)	4		Prostate(175;0.0199)																---	---	---	---
C10orf68	79741	broad.mit.edu	37	10	32983820	32983820	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32983820A>G	uc001iwn.3	+	6	752	c.279A>G	c.(277-279)GAA>GAG	p.E93E	C10orf68_uc001iwl.1_Silent_p.E101E|C10orf68_uc001iwm.1_Intron|C10orf68_uc010qei.1_Silent_p.E20E	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	93										skin(2)|ovary(1)	3																		---	---	---	---
NRP1	8829	broad.mit.edu	37	10	33474553	33474553	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33474553T>C	uc001iwx.3	-						NRP1_uc001iwv.3_Intron|NRP1_uc009xlz.2_Intron|NRP1_uc001iww.3_Intron|NRP1_uc001iwy.3_Intron	NM_003873	NP_003864			neuropilin 1 isoform a						axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)													---	---	---	---
NRP1	8829	broad.mit.edu	37	10	33481334	33481334	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33481334T>C	uc001iwx.3	-	13	2460	c.1937A>G	c.(1936-1938)TAT>TGT	p.Y646C	NRP1_uc001iwv.3_Missense_Mutation_p.Y646C|NRP1_uc009xlz.2_Missense_Mutation_p.Y639C|NRP1_uc001iww.3_Missense_Mutation_p.Y458C|NRP1_uc001iwy.3_Missense_Mutation_p.Y639C	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	646	Extracellular (Potential).|MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)													---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34620065	34620065	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34620065T>C	uc010qej.1	-	19	2822	c.2822A>G	c.(2821-2823)GAT>GGT	p.D941G	PARD3_uc010qek.1_Missense_Mutation_p.D938G|PARD3_uc010qel.1_Missense_Mutation_p.D941G|PARD3_uc010qem.1_Missense_Mutation_p.D925G|PARD3_uc010qen.1_Missense_Mutation_p.D895G|PARD3_uc010qeo.1_Missense_Mutation_p.D895G|PARD3_uc010qep.1_Missense_Mutation_p.D851G|PARD3_uc010qeq.1_Missense_Mutation_p.D866G|PARD3_uc001ixo.1_Missense_Mutation_p.D654G|PARD3_uc001ixp.1_Missense_Mutation_p.D772G|PARD3_uc001ixq.1_Missense_Mutation_p.D895G|PARD3_uc001ixr.1_Missense_Mutation_p.D938G|PARD3_uc001ixt.1_Missense_Mutation_p.D759G|PARD3_uc001ixu.1_Missense_Mutation_p.D883G|PARD3_uc001ixs.1_Missense_Mutation_p.D564G	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	941					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34739363	34739363	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34739363T>C	uc010qej.1	-	5	596	c.596A>G	c.(595-597)TAC>TGC	p.Y199C	PARD3_uc010qek.1_Missense_Mutation_p.Y199C|PARD3_uc010qel.1_Missense_Mutation_p.Y199C|PARD3_uc010qem.1_Missense_Mutation_p.Y199C|PARD3_uc010qen.1_Missense_Mutation_p.Y199C|PARD3_uc010qeo.1_Missense_Mutation_p.Y199C|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron|PARD3_uc001ixp.1_Missense_Mutation_p.Y64C|PARD3_uc001ixq.1_Missense_Mutation_p.Y199C|PARD3_uc001ixr.1_Missense_Mutation_p.Y199C|PARD3_uc001ixt.1_Intron|PARD3_uc001ixu.1_Intron	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	199					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
ZNF33A	7581	broad.mit.edu	37	10	38345181	38345181	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38345181T>C	uc001izh.2	+	5	2304	c.2126T>C	c.(2125-2127)GTA>GCA	p.V709A	ZNF33A_uc001izg.2_Missense_Mutation_p.V710A|ZNF33A_uc010qev.1_Missense_Mutation_p.V716A|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	709	C2H2-type 14.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
ZNF33A	7581	broad.mit.edu	37	10	38345257	38345257	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38345257A>G	uc001izh.2	+	5	2380	c.2202A>G	c.(2200-2202)GAA>GAG	p.E734E	ZNF33A_uc001izg.2_Silent_p.E735E|ZNF33A_uc010qev.1_Silent_p.E741E|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	734	C2H2-type 15.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
BMS1	9790	broad.mit.edu	37	10	43319235	43319235	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43319235A>G	uc001jaj.2	+							NM_014753	NP_055568			BMS1-like, ribosome assembly protein						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
HNRNPF	3185	broad.mit.edu	37	10	43882564	43882564	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43882564T>C	uc009xmh.1	-	3	1256	c.769A>G	c.(769-771)ACC>GCC	p.T257A	HNRNPF_uc001jar.2_Missense_Mutation_p.T257A|HNRNPF_uc001jas.2_Missense_Mutation_p.T257A|HNRNPF_uc001jat.2_Missense_Mutation_p.T257A|HNRNPF_uc001jav.2_Missense_Mutation_p.T257A|HNRNPF_uc001jau.2_Missense_Mutation_p.T257A|uc010qfa.1_Silent_p.G82G	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	257					regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0																		---	---	---	---
ZNF22	7570	broad.mit.edu	37	10	45499107	45499107	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:45499107T>C	uc001jbw.2	+	2	534	c.291T>C	c.(289-291)AAT>AAC	p.N97N	C10orf25_uc010qff.1_5'Flank|C10orf25_uc001jbv.1_5'Flank|uc001jbx.1_RNA	NM_006963	NP_008894	P17026	ZNF22_HUMAN	zinc finger protein 22 (KOX 15)	97	C2H2-type 2.				odontogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|plasma membrane	DNA binding|zinc ion binding			breast(1)|kidney(1)	2		Prostate(175;0.0352)|all_neural(218;0.202)																---	---	---	---
ANUBL1	93550	broad.mit.edu	37	10	46159025	46159025	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:46159025A>G	uc001jcp.3	-	2	391	c.149T>C	c.(148-150)GTT>GCT	p.V50A	ANUBL1_uc001jcm.3_Missense_Mutation_p.V50A|ANUBL1_uc009xmu.2_5'UTR|ANUBL1_uc001jcn.3_5'UTR|ANUBL1_uc001jco.3_Missense_Mutation_p.V50A|ANUBL1_uc001jcq.2_RNA|ANUBL1_uc001jcr.2_Missense_Mutation_p.V50A	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	50	Ubiquitin-like.						zinc ion binding				0																		---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49395242	49395242	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49395242C>A	uc001jgi.2	-	17	2366	c.2259G>T	c.(2257-2259)ATG>ATT	p.M753I	FRMPD2_uc001jgh.2_Missense_Mutation_p.M721I|FRMPD2_uc001jgj.2_Missense_Mutation_p.M731I	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	753					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49400886	49400886	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49400886C>T	uc001jgi.2	-	16	2113	c.2006G>A	c.(2005-2007)CGG>CAG	p.R669Q	FRMPD2_uc001jgh.2_Missense_Mutation_p.R637Q|FRMPD2_uc001jgj.2_Missense_Mutation_p.R647Q	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	669					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49447676	49447676	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49447676G>A	uc001jgi.2	-	7	867	c.760C>T	c.(760-762)CAC>TAC	p.H254Y	FRMPD2_uc001jgh.2_Missense_Mutation_p.H223Y|FRMPD2_uc001jgj.2_Missense_Mutation_p.H232Y	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	254					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
C10orf71	118461	broad.mit.edu	37	10	50532305	50532305	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50532305C>T	uc010qgp.1	+	3	2054	c.1715C>T	c.(1714-1716)CCC>CTC	p.P572L		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	572											0																		---	---	---	---
OGDHL	55753	broad.mit.edu	37	10	50946030	50946030	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50946030A>G	uc001jie.2	-	19	2622	c.2480T>C	c.(2479-2481)GTG>GCG	p.V827A	OGDHL_uc009xog.2_Missense_Mutation_p.V854A|OGDHL_uc010qgt.1_Missense_Mutation_p.V770A|OGDHL_uc010qgu.1_Missense_Mutation_p.V618A	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	827					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1																		---	---	---	---
OGDHL	55753	broad.mit.edu	37	10	50957801	50957801	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50957801A>G	uc001jie.2	-	8	1100	c.958T>C	c.(958-960)TTT>CTT	p.F320L	OGDHL_uc009xog.2_Missense_Mutation_p.F347L|OGDHL_uc010qgt.1_Missense_Mutation_p.F263L|OGDHL_uc010qgu.1_Missense_Mutation_p.F111L|OGDHL_uc009xoh.2_Missense_Mutation_p.F111L	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	320					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1																		---	---	---	---
BICC1	80114	broad.mit.edu	37	10	60562876	60562876	+	Silent	SNP	T	C	C	rs139787636		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60562876T>C	uc001jki.1	+	15	2055	c.2055T>C	c.(2053-2055)GCT>GCC	p.A685A	BICC1_uc001jkj.1_Silent_p.A326A	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	685					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
PHYHIPL	84457	broad.mit.edu	37	10	60994089	60994089	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60994089A>G	uc001jkk.3	+	2	398	c.132A>G	c.(130-132)ATA>ATG	p.I44M	PHYHIPL_uc001jkl.3_Translation_Start_Site|PHYHIPL_uc001jkm.3_Missense_Mutation_p.I18M	NM_032439	NP_115815	Q96FC7	PHIPL_HUMAN	phytanoyl-CoA 2-hydroxylase interacting	44											0																		---	---	---	---
FAM13C	220965	broad.mit.edu	37	10	61112119	61112119	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61112119C>T	uc001jkn.2	-	4	369	c.235G>A	c.(235-237)GTA>ATA	p.V79I	FAM13C_uc001jko.2_Missense_Mutation_p.V79I|FAM13C_uc010qid.1_5'UTR|FAM13C_uc010qie.1_5'UTR|FAM13C_uc010qif.1_Missense_Mutation_p.V101I|FAM13C_uc001jkp.2_5'UTR	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	79										ovary(2)	2																		---	---	---	---
SLC16A9	220963	broad.mit.edu	37	10	61413938	61413938	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61413938A>G	uc010qig.1	-	5	1295	c.846T>C	c.(844-846)CTT>CTC	p.L282L		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	282	Extracellular (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61832609	61832609	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61832609A>G	uc001jky.2	-	37	8222	c.8030T>C	c.(8029-8031)GTT>GCT	p.V2677A	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2677					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ARID5B	84159	broad.mit.edu	37	10	63852092	63852092	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63852092T>C	uc001jlt.1	+	10	2896	c.2870T>C	c.(2869-2871)GTA>GCA	p.V957A		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	957					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64944406	64944406	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64944406A>G	uc001jmn.2	-	21	7223	c.6923T>C	c.(6922-6924)GTA>GCA	p.V2308A	JMJD1C_uc001jml.2_Missense_Mutation_p.V2071A|JMJD1C_uc001jmm.2_Missense_Mutation_p.V2020A|JMJD1C_uc010qiq.1_Missense_Mutation_p.V2126A|JMJD1C_uc009xpi.2_Missense_Mutation_p.V2126A|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_Missense_Mutation_p.V215A	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2308	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding	p.V2071E(1)		ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
JMJD1C	221037	broad.mit.edu	37	10	64967249	64967249	+	Missense_Mutation	SNP	T	C	C	rs139881253	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64967249T>C	uc001jmn.2	-	10	4480	c.4180A>G	c.(4180-4182)ACC>GCC	p.T1394A	JMJD1C_uc001jml.2_Missense_Mutation_p.T1175A|JMJD1C_uc001jmm.2_Missense_Mutation_p.T1106A|JMJD1C_uc010qiq.1_Missense_Mutation_p.T1212A|JMJD1C_uc009xpi.2_Missense_Mutation_p.T1212A|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.T431A	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1394					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)																	---	---	---	---
CTNNA3	29119	broad.mit.edu	37	10	67748557	67748557	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:67748557T>C	uc009xpn.1	-	16	2283	c.2160_splice	c.e16-1	p.R720_splice	CTNNA3_uc001jmw.2_Splice_Site_p.R720_splice	NM_001127384	NP_001120856			catenin, alpha 3						cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8																		---	---	---	---
HERC4	26091	broad.mit.edu	37	10	69785304	69785304	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69785304G>A	uc001jng.3	-	8	1218	c.907C>T	c.(907-909)CGG>TGG	p.R303W	HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.R303W|HERC4_uc009xpr.2_Missense_Mutation_p.R303W|HERC4_uc001jni.3_Missense_Mutation_p.R47W|HERC4_uc001jnj.2_Missense_Mutation_p.R303W	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	303	RCC1 6.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
DNA2	1763	broad.mit.edu	37	10	70191674	70191674	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70191674T>C	uc001jof.2	-	13	2186	c.2186A>G	c.(2185-2187)TAC>TGC	p.Y729C	DNA2_uc001jog.1_Missense_Mutation_p.Y643C|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	643					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0																		---	---	---	---
TET1	80312	broad.mit.edu	37	10	70405606	70405606	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70405606A>G	uc001jok.3	+	4	3625	c.3120A>G	c.(3118-3120)CCA>CCG	p.P1040P		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1040					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9																		---	---	---	---
DDX50	79009	broad.mit.edu	37	10	70672961	70672961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70672961C>T	uc001jou.2	+	5	790	c.683C>T	c.(682-684)GCC>GTC	p.A228V	DDX50_uc001jot.2_Missense_Mutation_p.A228V|DDX50_uc010qjc.1_Missense_Mutation_p.A228V	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	228	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1																		---	---	---	---
VPS26A	9559	broad.mit.edu	37	10	70925872	70925872	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70925872A>G	uc001jpb.2	+						VPS26A_uc001jpc.2_Intron|VPS26A_uc009xqa.2_Intron|VPS26A_uc001jpd.2_Intron	NM_004896	NP_004887			vacuolar protein sorting 26 A isoform 1						retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity				0																		---	---	---	---
SUPV3L1	6832	broad.mit.edu	37	10	70951476	70951476	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70951476T>C	uc001jpe.1	+	6	862	c.807T>C	c.(805-807)GCT>GCC	p.A269A	SUPV3L1_uc010qjd.1_Silent_p.A138A	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	269	Helicase ATP-binding.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2																		---	---	---	---
HKDC1	80201	broad.mit.edu	37	10	71003054	71003054	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71003054C>A	uc001jpf.3	+	7	941	c.808C>A	c.(808-810)CTG>ATG	p.L270M	HKDC1_uc010qje.1_Missense_Mutation_p.L133M	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	270					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5																		---	---	---	---
HK1	3098	broad.mit.edu	37	10	71128328	71128328	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71128328A>G	uc001jpl.3	+	5	633	c.532A>G	c.(532-534)AGC>GGC	p.S178G	HK1_uc001jpg.3_Missense_Mutation_p.S166G|HK1_uc001jph.3_Missense_Mutation_p.S182G|HK1_uc001jpi.3_Missense_Mutation_p.S182G|HK1_uc001jpj.3_Missense_Mutation_p.S213G|HK1_uc001jpk.3_Missense_Mutation_p.S177G|HK1_uc009xqd.2_Missense_Mutation_p.S56G	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	178	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1																		---	---	---	---
PPA1	5464	broad.mit.edu	37	10	71970146	71970146	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71970146T>C	uc001jqv.1	-							NM_021129	NP_066952			pyrophosphatase 1						diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(1)	1																		---	---	---	---
ADAMTS14	140766	broad.mit.edu	37	10	72520481	72520481	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72520481A>G	uc001jrh.2	+	22	3544	c.3544A>G	c.(3544-3546)ACC>GCC	p.T1182A	ADAMTS14_uc001jrg.2_Missense_Mutation_p.T1185A	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1182	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73498265	73498265	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73498265C>T	uc001jrx.3	+	33	4597	c.4220C>T	c.(4219-4221)ACT>ATT	p.T1407I	C10orf105_uc001jsb.1_5'Flank|CDH23_uc001jsc.1_Missense_Mutation_p.T214I	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1407	Cadherin 13.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
CDH23	64072	broad.mit.edu	37	10	73553070	73553070	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:73553070A>T	uc001jrx.3	+	46	6762	c.6385A>T	c.(6385-6387)AAT>TAT	p.N2129Y	CDH23_uc001jsg.3_5'Flank|CDH23_uc001jsh.3_5'Flank	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	2129	Cadherin 20.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11																		---	---	---	---
DNAJB12	54788	broad.mit.edu	37	10	74095633	74095633	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74095633C>A	uc010qjv.1	-	8	1315	c.1165G>T	c.(1165-1167)GCA>TCA	p.A389S	DNAJB12_uc001jsz.2_Missense_Mutation_p.A389S|DNAJB12_uc001jta.2_Missense_Mutation_p.A389S	NM_017626	NP_060096	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	355					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding				0																		---	---	---	---
P4HA1	5033	broad.mit.edu	37	10	74813265	74813265	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74813265T>C	uc010qka.1	-	7	881	c.547A>G	c.(547-549)ACG>GCG	p.T183A	P4HA1_uc001jtg.2_Missense_Mutation_p.T183A|P4HA1_uc001jth.2_Missense_Mutation_p.T183A|P4HA1_uc010qkb.1_Missense_Mutation_p.T183A|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	183						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
TTC18	118491	broad.mit.edu	37	10	75051441	75051441	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75051441A>G	uc009xrc.2	-	19	2308	c.2187T>C	c.(2185-2187)GCT>GCC	p.A729A	TTC18_uc001jty.2_Silent_p.A729A|TTC18_uc001jtv.3_5'Flank|TTC18_uc001jtw.3_5'Flank|TTC18_uc001jtx.2_Silent_p.A110A	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	729	TPR 3.						binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75302625	75302625	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75302625C>T	uc001juo.2	-	5	525	c.508G>A	c.(508-510)GGT>AGT	p.G170S	USP54_uc001jum.2_5'Flank|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.G170S|USP54_uc010qkl.1_Missense_Mutation_p.G170S|USP54_uc001juq.1_5'Flank	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	170					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75331193	75331193	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75331193A>G	uc001juo.2	-	2	243	c.226T>C	c.(226-228)TTT>CTT	p.F76L	USP54_uc001jup.2_Missense_Mutation_p.F76L|USP54_uc010qkl.1_Missense_Mutation_p.F76L	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	76					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
SEC24C	9632	broad.mit.edu	37	10	75511011	75511011	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75511011T>C	uc001juw.2	+						SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Intron|SEC24C_uc001jux.2_Intron|SEC24C_uc010qko.1_Intron|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913			SEC24-related protein C						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)																	---	---	---	---
NDST2	8509	broad.mit.edu	37	10	75563469	75563469	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75563469T>C	uc001jvk.2	-	11	2809	c.2005A>G	c.(2005-2007)ACT>GCT	p.T669A	NDST2_uc010qks.1_Missense_Mutation_p.T295A|NDST2_uc010qkt.1_Missense_Mutation_p.T546A|NDST2_uc001jvl.1_Missense_Mutation_p.T76A|NDST2_uc009xro.2_Missense_Mutation_p.T295A|NDST2_uc010qku.1_Missense_Mutation_p.T544A	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	669	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)																	---	---	---	---
CAMK2G	818	broad.mit.edu	37	10	75612083	75612083	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75612083A>G	uc001jvv.1	-						CAMK2G_uc001jvm.1_Intron|CAMK2G_uc001jvo.1_Intron|CAMK2G_uc001jvq.1_Intron|CAMK2G_uc001jvr.1_Intron|CAMK2G_uc001jvp.1_Intron|CAMK2G_uc001jvs.1_Intron|CAMK2G_uc001jvt.1_Intron|CAMK2G_uc001jvu.1_Intron|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911			calcium/calmodulin-dependent protein kinase II						insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)																	---	---	---	---
DLG5	9231	broad.mit.edu	37	10	79589141	79589141	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79589141C>T	uc001jzk.2	-	12	2227	c.2157G>A	c.(2155-2157)CCG>CCA	p.P719P	DLG5_uc001jzj.2_Silent_p.P474P|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Silent_p.P323P	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	719	PDZ 2.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)															---	---	---	---
DLG5	9231	broad.mit.edu	37	10	79590513	79590513	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79590513A>G	uc001jzk.2	-	10	1937	c.1867T>C	c.(1867-1869)TTC>CTC	p.F623L	DLG5_uc001jzj.2_Missense_Mutation_p.F378L|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.F227L	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	623	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)															---	---	---	---
POLR3A	11128	broad.mit.edu	37	10	79769355	79769355	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79769355G>T	uc001jzn.2	-	14	1943	c.1849C>A	c.(1849-1851)CTG>ATG	p.L617M		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	617					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)															---	---	---	---
ZMIZ1	57178	broad.mit.edu	37	10	81056311	81056311	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:81056311G>A	uc001kaf.2	+	13	1886	c.1314G>A	c.(1312-1314)AGG>AGA	p.R438R	ZMIZ1_uc001kag.2_Silent_p.R314R|ZMIZ1_uc001kah.1_3'UTR	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	438	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)															---	---	---	---
GRID1	2894	broad.mit.edu	37	10	87615784	87615784	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:87615784A>G	uc001kdl.1	-	7	1214	c.1113_splice	c.e7+1	p.K371_splice	GRID1_uc009xsu.1_Splice_Site	NM_017551	NP_060021			glutamate receptor, ionotropic, delta 1							cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)										Multiple Myeloma(13;0.14)			---	---	---	---
C10orf116	10974	broad.mit.edu	37	10	88728350	88728350	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88728350G>A	uc001ked.2	+	1	163	c.49G>A	c.(49-51)GCC>ACC	p.A17T	AGAP11_uc001kee.2_5'Flank|uc001kec.1_3'UTR	NM_006829	NP_006820	Q15847	APM2_HUMAN	adipose specific 2	17											0																		---	---	---	---
AGAP11	119385	broad.mit.edu	37	10	88761502	88761502	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88761502A>G	uc001kee.2	+						AGAP11_uc001kef.2_Intron	NM_133447	NP_597704			ankyrin repeat and GTPase domain Arf GTPase						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0																		---	---	---	---
ATAD1	84896	broad.mit.edu	37	10	89574266	89574266	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:89574266A>G	uc001key.1	-	1	374	c.91T>C	c.(91-93)TAC>CAC	p.Y31H	ATAD1_uc009xth.1_RNA|ATAD1_uc001kez.1_Missense_Mutation_p.Y31H	NM_032810	NP_116199	Q8NBU5	ATAD1_HUMAN	ATPase family, AAA domain containing 1	31						peroxisome	ATP binding|nucleoside-triphosphatase activity			large_intestine(1)|ovary(1)	2		all_cancers(4;6.78e-12)|Prostate(4;3.56e-12)|all_epithelial(4;5.58e-09)|Melanoma(5;0.0273)|Breast(4;0.0424)|all_hematologic(4;0.0846)|Colorectal(252;0.207)|Glioma(4;0.217)|all_neural(4;0.224)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00131)|GBM - Glioblastoma multiforme(1;1.1e-32)|Lung(2;1.4e-05)|LUSC - Lung squamous cell carcinoma(2;2.69e-05)|Colorectal(12;7.09e-05)|COAD - Colon adenocarcinoma(12;0.000261)|STAD - Stomach adenocarcinoma(243;0.235)														---	---	---	---
IFIT3	3437	broad.mit.edu	37	10	91098570	91098570	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:91098570T>C	uc001kgf.2	+	2	387	c.158T>C	c.(157-159)ATG>ACG	p.M53T	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron|IFIT3_uc001kgg.2_Missense_Mutation_p.M53T	NM_001549	NP_001540	O14879	IFIT3_HUMAN	interferon-induced protein with	53	TPR 1.				type I interferon-mediated signaling pathway		protein binding			central_nervous_system(1)	1																		---	---	---	---
HECTD2	143279	broad.mit.edu	37	10	93185148	93185148	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93185148T>C	uc001khl.2	+	2	349	c.249T>C	c.(247-249)GTT>GTC	p.V83V	LOC100188947_uc010qnl.1_Intron|HECTD2_uc001khk.2_Silent_p.V83V|HECTD2_uc010qnm.1_Silent_p.V83V|HECTD2_uc001khm.2_RNA	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	83					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1																		---	---	---	---
TNKS2	80351	broad.mit.edu	37	10	93596680	93596680	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93596680T>C	uc001khp.2	+	13	1749	c.1452T>C	c.(1450-1452)GGT>GGC	p.G484G		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	484					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93740227	93740227	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93740227T>C	uc001khr.2	+	15	1765	c.1667T>C	c.(1666-1668)CTT>CCT	p.L556P	BTAF1_uc001khs.1_Missense_Mutation_p.L226P|BTAF1_uc001kht.1_5'UTR	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	556	HEAT 4.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
CPEB3	22849	broad.mit.edu	37	10	93940759	93940759	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93940759A>G	uc001khw.1	-	4	1356	c.1183T>C	c.(1183-1185)TTC>CTC	p.F395L	CPEB3_uc001khu.1_Missense_Mutation_p.F395L|CPEB3_uc001khv.1_Missense_Mutation_p.F372L|CPEB3_uc010qnn.1_Missense_Mutation_p.F372L	NM_014912	NP_055727	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding	395							nucleotide binding|RNA binding				0		Colorectal(252;0.0869)																---	---	---	---
MARCH5	54708	broad.mit.edu	37	10	94070932	94070932	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94070932A>C	uc001khx.1	+	2	408	c.76A>C	c.(76-78)ACA>CCA	p.T26P	MARCH5_uc010qno.1_5'UTR	NM_017824	NP_060294	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	26	RING-CH-type.				cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
IDE	3416	broad.mit.edu	37	10	94269801	94269801	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94269801A>G	uc001kia.2	-							NM_004969	NP_004960			insulin-degrading enzyme isoform 1 precursor						beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
CYP26A1	1592	broad.mit.edu	37	10	94834724	94834724	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94834724G>A	uc001kil.2	+	3	648	c.603G>A	c.(601-603)GCG>GCA	p.A201A	CYP26A1_uc001kik.1_Silent_p.A132A|CYP26A1_uc001kim.1_Silent_p.A99A	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	201					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)																---	---	---	---
PDE6C	5146	broad.mit.edu	37	10	95399875	95399875	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95399875T>C	uc001kiu.3	+	12	1669	c.1531T>C	c.(1531-1533)TTC>CTC	p.F511L		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	511					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)																---	---	---	---
PDE6C	5146	broad.mit.edu	37	10	95400298	95400298	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95400298T>G	uc001kiu.3	+	13	1859	c.1721T>G	c.(1720-1722)ATG>AGG	p.M574R		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	574					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)																---	---	---	---
C10orf4	118924	broad.mit.edu	37	10	95458056	95458056	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95458056A>G	uc001kiz.1	-	3	371	c.173_splice	c.e3+1	p.R58_splice	C10orf4_uc001kiv.1_Splice_Site|C10orf4_uc001kja.1_Splice_Site_p.R58_splice|C10orf4_uc001kjb.1_Splice_Site_p.R58_splice|C10orf4_uc009xuh.1_Splice_Site_p.R59_splice	NM_145246	NP_660289			FRA10AC1 protein							nucleus	protein binding				0		Colorectal(252;0.122)																---	---	---	---
PLCE1	51196	broad.mit.edu	37	10	96081696	96081696	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96081696G>T	uc001kjk.2	+	30	7015	c.6381G>T	c.(6379-6381)GAG>GAT	p.E2127D	PLCE1_uc010qnx.1_Missense_Mutation_p.E2111D|PLCE1_uc001kjm.2_Missense_Mutation_p.E1819D|PLCE1_uc001kjp.2_Missense_Mutation_p.E485D	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	2127					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)																---	---	---	---
HELLS	3070	broad.mit.edu	37	10	96306134	96306134	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96306134G>A	uc001kjt.2	+	2	137	c.32G>A	c.(31-33)GGC>GAC	p.G11D	HELLS_uc001kjs.2_5'UTR|HELLS_uc009xul.2_Missense_Mutation_p.G11D|HELLS_uc009xum.2_Missense_Mutation_p.G11D|HELLS_uc009xun.2_5'UTR|HELLS_uc009xuo.2_Missense_Mutation_p.G11D|HELLS_uc001kju.2_5'UTR|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_5'UTR|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	11					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)														---	---	---	---
CYP2C18	1562	broad.mit.edu	37	10	96493085	96493085	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96493085T>C	uc001kjv.3	+	8	1507	c.1181T>C	c.(1180-1182)GTG>GCG	p.V394A	CYP2C18_uc001kjw.3_Missense_Mutation_p.V335A|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	394					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)														---	---	---	---
ALDH18A1	5832	broad.mit.edu	37	10	97387227	97387227	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97387227A>G	uc001kkz.2	-	9	1292	c.1050T>C	c.(1048-1050)GGT>GGC	p.G350G	ALDH18A1_uc001kky.2_Silent_p.G348G|ALDH18A1_uc010qog.1_Silent_p.G239G|ALDH18A1_uc010qoh.1_Silent_p.G138G	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	350	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)													---	---	---	---
ALDH18A1	5832	broad.mit.edu	37	10	97392721	97392721	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97392721A>G	uc001kkz.2	-	7	1045	c.803T>C	c.(802-804)GTA>GCA	p.V268A	ALDH18A1_uc001kky.2_Missense_Mutation_p.V266A|ALDH18A1_uc010qog.1_Missense_Mutation_p.V157A|ALDH18A1_uc010qoh.1_Missense_Mutation_p.V56A	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	268	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)													---	---	---	---
ENTPD1	953	broad.mit.edu	37	10	97607278	97607278	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97607278T>C	uc001klh.3	+	7	1213	c.889T>C	c.(889-891)TAC>CAC	p.Y297H	ENTPD1_uc001kli.3_Missense_Mutation_p.Y304H|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Missense_Mutation_p.Y309H|ENTPD1_uc010qok.1_Missense_Mutation_p.Y189H|ENTPD1_uc010qol.1_Missense_Mutation_p.Y189H|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Missense_Mutation_p.Y159H|ENTPD1_uc009xva.2_Missense_Mutation_p.Y159H|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	297	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)														---	---	---	---
ZNF518A	9849	broad.mit.edu	37	10	97916643	97916643	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97916643T>A	uc001klp.2	+	6	1421	c.564T>A	c.(562-564)TAT>TAA	p.Y188*	ZNF518A_uc001klo.1_Intron|ZNF518A_uc001klq.2_Nonsense_Mutation_p.Y188*|ZNF518A_uc001klr.2_Nonsense_Mutation_p.Y188*	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)														---	---	---	---
ZNF518A	9849	broad.mit.edu	37	10	97918869	97918869	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97918869A>G	uc001klp.2	+	6	3647	c.2790A>G	c.(2788-2790)ATA>ATG	p.I930M	ZNF518A_uc001klo.1_Missense_Mutation_p.I400M|ZNF518A_uc001klq.2_Missense_Mutation_p.I930M|ZNF518A_uc001klr.2_Missense_Mutation_p.I930M	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	930					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)														---	---	---	---
ZNF518A	9849	broad.mit.edu	37	10	97920061	97920061	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97920061C>T	uc001klp.2	+	6	4839	c.3982C>T	c.(3982-3984)CGG>TGG	p.R1328W	ZNF518A_uc001klo.1_Missense_Mutation_p.R798W|ZNF518A_uc001klq.2_Missense_Mutation_p.R1328W|ZNF518A_uc001klr.2_Missense_Mutation_p.R1328W	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)														---	---	---	---
TM9SF3	56889	broad.mit.edu	37	10	98287919	98287919	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98287919C>T	uc001kmm.3	-	12	1627	c.1410G>A	c.(1408-1410)ACG>ACA	p.T470T	TM9SF3_uc010qot.1_Silent_p.T470T	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	470						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)														---	---	---	---
SLIT1	6585	broad.mit.edu	37	10	98807442	98807442	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98807442C>A	uc001kmw.2	-						SLIT1_uc009xvh.1_Intron	NM_003061	NP_003052			slit homolog 1 precursor						axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)														---	---	---	---
RRP12	23223	broad.mit.edu	37	10	99126849	99126849	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99126849T>A	uc001knf.2	-	26	3135	c.2996A>T	c.(2995-2997)CAC>CTC	p.H999L	RRP12_uc001kne.2_Missense_Mutation_p.H14L|RRP12_uc009xvl.2_Missense_Mutation_p.H116L|RRP12_uc009xvm.2_Missense_Mutation_p.H717L|RRP12_uc010qou.1_Missense_Mutation_p.H938L|RRP12_uc009xvn.2_Missense_Mutation_p.H899L	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	999						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)														---	---	---	---
RRP12	23223	broad.mit.edu	37	10	99132949	99132949	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99132949G>A	uc001knf.2	-	18	2174	c.2035C>T	c.(2035-2037)CGT>TGT	p.R679C	RRP12_uc009xvl.2_5'UTR|RRP12_uc009xvm.2_Missense_Mutation_p.R397C|RRP12_uc010qou.1_Missense_Mutation_p.R618C|RRP12_uc009xvn.2_Missense_Mutation_p.R579C	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	679						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)														---	---	---	---
RRP12	23223	broad.mit.edu	37	10	99148278	99148278	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99148278T>C	uc001knf.2	-	7	996	c.857A>G	c.(856-858)AAG>AGG	p.K286R	RRP12_uc009xvm.2_Intron|RRP12_uc010qou.1_Missense_Mutation_p.K225R|RRP12_uc009xvn.2_Missense_Mutation_p.K186R	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	286						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)														---	---	---	---
UBTD1	80019	broad.mit.edu	37	10	99330203	99330203	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99330203C>T	uc001knv.1	+	3	800	c.607C>T	c.(607-609)CGG>TGG	p.R203W	ANKRD2_uc001knw.2_5'Flank|ANKRD2_uc009xvu.2_5'Flank	NM_024954	NP_079230	Q9HAC8	UBTD1_HUMAN	ubiquitin domain containing 1	203	Ubiquitin-like.										0		Colorectal(252;0.162)		Epithelial(162;3.04e-10)|all cancers(201;2.86e-08)														---	---	---	---
ZFYVE27	118813	broad.mit.edu	37	10	99498302	99498302	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99498302T>C	uc001koo.2	+	2	268	c.68T>C	c.(67-69)CTG>CCG	p.L23P	ZFYVE27_uc001kon.2_Missense_Mutation_p.L23P|ZFYVE27_uc001koq.2_Missense_Mutation_p.L23P|ZFYVE27_uc010qpa.1_Missense_Mutation_p.L23P|ZFYVE27_uc001kop.2_Missense_Mutation_p.L23P|ZFYVE27_uc010qpb.1_Intron|ZFYVE27_uc010qpc.1_RNA|ZFYVE27_uc010qpd.1_Missense_Mutation_p.L23P|ZFYVE27_uc001kok.1_RNA|ZFYVE27_uc001kol.1_Missense_Mutation_p.L23P|ZFYVE27_uc001kom.1_Missense_Mutation_p.L23P	NM_144588	NP_653189	Q5T4F4	ZFY27_HUMAN	zinc finger, FYVE domain containing 27 isoform	23	Cytoplasmic (Potential).				cell death|nerve growth factor receptor signaling pathway|neuron projection development|protein localization in plasma membrane	axon|dendrite|endoplasmic reticulum membrane|growth cone membrane|integral to membrane|recycling endosome membrane	metal ion binding|protein binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;7.08e-10)|all cancers(201;5.18e-08)														---	---	---	---
LOXL4	84171	broad.mit.edu	37	10	100012116	100012116	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100012116G>A	uc001kpa.1	-	12	2096	c.1945C>T	c.(1945-1947)CCC>TCC	p.P649S		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	649	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)														---	---	---	---
PYROXD2	84795	broad.mit.edu	37	10	100167720	100167720	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100167720G>A	uc001kpc.2	-	3	268	c.182C>T	c.(181-183)GCC>GTC	p.A61V	PYROXD2_uc001kpb.2_RNA|PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Missense_Mutation_p.A61V	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	61	FAD (Potential).						oxidoreductase activity			central_nervous_system(1)	1																		---	---	---	---
HPS1	3257	broad.mit.edu	37	10	100189313	100189313	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100189313T>C	uc010qpf.1	-						HPS1_uc001kpi.1_Intron|HPS1_uc001kpj.1_Intron|HPS1_uc001kpk.1_Intron|HPS1_uc009xwb.2_Intron|HPS1_uc010qph.1_Intron|HPS1_uc001kpl.2_Silent_p.K318K	NM_000195	NP_000186			Hermansky-Pudlak syndrome 1 protein isoform a						lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)										Hermansky-Pudlak_syndrome				---	---	---	---
SLC25A28	81894	broad.mit.edu	37	10	101373648	101373648	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101373648C>T	uc001kpx.2	-	2	454	c.325G>A	c.(325-327)GCC>ACC	p.A109T	SLC25A28_uc001kpy.2_5'UTR|SLC25A28_uc009xwk.1_Missense_Mutation_p.A109T	NM_031212	NP_112489	Q96A46	MFRN2_HUMAN	solute carrier family 25, member 28	109	Solcar 1.				ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)														---	---	---	---
ABCC2	1244	broad.mit.edu	37	10	101567244	101567244	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101567244T>C	uc001kqf.2	+	12	1773	c.1634T>C	c.(1633-1635)GTA>GCA	p.V545A		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	545	ABC transmembrane type-1 1.|Helical; Name=10; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
ABCC2	1244	broad.mit.edu	37	10	101591749	101591749	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101591749T>C	uc001kqf.2	+	23	3258	c.3119T>C	c.(3118-3120)ATA>ACA	p.I1040T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1040	ABC transmembrane type-1 2.|Helical; Name=13; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
DNMBP	23268	broad.mit.edu	37	10	101656041	101656041	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101656041T>C	uc001kqj.2	-	10	3126	c.3034A>G	c.(3034-3036)ACT>GCT	p.T1012A	DNMBP_uc010qpl.1_Intron|DNMBP_uc001kqg.2_Missense_Mutation_p.T300A|DNMBP_uc001kqh.2_Missense_Mutation_p.T644A	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1012	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)														---	---	---	---
SEC31B	25956	broad.mit.edu	37	10	102249885	102249885	+	Missense_Mutation	SNP	G	A	A	rs146812157	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102249885G>A	uc001krc.1	-	21	2947	c.2845C>T	c.(2845-2847)CGC>TGC	p.R949C	SEC31B_uc010qpo.1_Missense_Mutation_p.R948C|SEC31B_uc001krd.1_Missense_Mutation_p.R486C|SEC31B_uc001krf.1_Intron|SEC31B_uc001kre.1_Intron	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	949	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)														---	---	---	---
FAM178A	55719	broad.mit.edu	37	10	102690834	102690834	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102690834G>A	uc001krt.3	+	9	2977	c.2435G>A	c.(2434-2436)CGG>CAG	p.R812Q	FAM178A_uc001krs.2_Missense_Mutation_p.R812Q	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	812											0																		---	---	---	---
FBXW4	6468	broad.mit.edu	37	10	103371117	103371117	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103371117A>G	uc001kto.2	-	9	1516	c.1170T>C	c.(1168-1170)CGT>CGC	p.R390R		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	390					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)														---	---	---	---
MGEA5	10724	broad.mit.edu	37	10	103551111	103551111	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103551111T>A	uc001ktv.2	-	13	2704	c.2261A>T	c.(2260-2262)AAG>ATG	p.K754M	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.K701M|MGEA5_uc009xws.2_Missense_Mutation_p.K687M	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	754	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)														---	---	---	---
MGEA5	10724	broad.mit.edu	37	10	103553747	103553747	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103553747T>C	uc001ktv.2	-	11	2436	c.1993A>G	c.(1993-1995)AGT>GGT	p.S665G	MGEA5_uc001ktu.2_Intron|MGEA5_uc010qqe.1_Missense_Mutation_p.S612G|MGEA5_uc009xws.2_Missense_Mutation_p.S612G	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	665	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)														---	---	---	---
MGEA5	10724	broad.mit.edu	37	10	103560141	103560141	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103560141A>G	uc001ktv.2	-	8	1496	c.1053T>C	c.(1051-1053)AGT>AGC	p.S351S	MGEA5_uc001ktu.2_5'Flank|MGEA5_uc010qqe.1_Intron|MGEA5_uc009xws.2_Intron|MGEA5_uc001ktw.2_Silent_p.S351S|MGEA5_uc009xwt.2_Silent_p.S114S	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	351					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)														---	---	---	---
KCNIP2	30819	broad.mit.edu	37	10	103587421	103587421	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103587421T>C	uc001kub.2	-						KCNIP2_uc010qqg.1_Intron|KCNIP2_uc001ktx.2_Intron|KCNIP2_uc001kty.2_Intron|KCNIP2_uc001ktz.2_Intron|KCNIP2_uc009xwu.2_Intron|KCNIP2_uc009xwv.2_Intron|KCNIP2_uc001kuc.2_Intron|KCNIP2_uc001kue.2_Intron|KCNIP2_uc001kud.2_Intron|KCNIP2_uc001kuf.2_Intron|KCNIP2_uc001kua.2_Intron|KCNIP2_uc009xww.2_Intron|KCNIP2_uc010qqh.1_Missense_Mutation_p.T219A|KCNIP2_uc010qqi.1_Missense_Mutation_p.T178A	NM_173191	NP_775283			Kv channel interacting protein 2 isoform 2						clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)														---	---	---	---
PITX3	5309	broad.mit.edu	37	10	103990855	103990855	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103990855A>G	uc001kuu.1	-	4	479	c.325T>C	c.(325-327)TGG>CGG	p.W109R		NM_005029	NP_005020	O75364	PITX3_HUMAN	paired-like homeodomain 3	109	Homeobox.				dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)														---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104127249	104127249	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104127249T>A	uc001kux.1	+	21	2811	c.2571T>A	c.(2569-2571)AAT>AAA	p.N857K	GBF1_uc001kuy.1_Missense_Mutation_p.N857K|GBF1_uc001kuz.1_Missense_Mutation_p.N858K	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	857	SEC7.				COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104129053	104129053	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104129053A>G	uc001kux.1	+	24	3296	c.3056A>G	c.(3055-3057)CAT>CGT	p.H1019R	GBF1_uc001kuy.1_Missense_Mutation_p.H1019R|GBF1_uc001kuz.1_Missense_Mutation_p.H1020R	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1019					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104129985	104129985	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104129985C>T	uc001kux.1	+	27	3631	c.3391C>T	c.(3391-3393)CTA>TTA	p.L1131L	GBF1_uc001kuy.1_Silent_p.L1131L|GBF1_uc001kuz.1_Silent_p.L1132L	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1131					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
CUEDC2	79004	broad.mit.edu	37	10	104183602	104183602	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104183602G>A	uc001kvn.2	-	7	760	c.609C>T	c.(607-609)CGC>CGT	p.R203R	CUEDC2_uc001kvm.2_5'Flank	NM_024040	NP_076945	Q9H467	CUED2_HUMAN	CUE domain containing 2	203						cytoplasm|nucleus	protein binding				0		Colorectal(252;0.122)		Epithelial(162;9.17e-09)|all cancers(201;2.16e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)														---	---	---	---
SUFU	51684	broad.mit.edu	37	10	104268964	104268964	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104268964A>G	uc001kvy.1	+	2	367	c.221A>G	c.(220-222)TAC>TGC	p.Y74C	SUFU_uc001kvw.1_Missense_Mutation_p.Y74C|SUFU_uc001kvx.2_Missense_Mutation_p.Y74C	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	74					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)				D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation				---	---	---	---
SUFU	51684	broad.mit.edu	37	10	104389822	104389822	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104389822G>A	uc001kvy.1	+	12	1512	c.1366_splice	c.e12-1	p.F456_splice	SUFU_uc009xxe.1_Splice_Site|SUFU_uc009xxf.1_Splice_Site	NM_016169	NP_057253			suppressor of fused						negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)				D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation				---	---	---	---
C10orf26	54838	broad.mit.edu	37	10	104557834	104557834	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104557834T>C	uc001kwe.3	+	2	372	c.112T>C	c.(112-114)TAC>CAC	p.Y38H	C10orf26_uc001kwf.3_Missense_Mutation_p.Y59H|C10orf26_uc009xxg.1_RNA	NM_017787	NP_060257	Q9NX94	OPA1L_HUMAN	hypothetical protein LOC54838 isoform 2	38						integral to membrane				central_nervous_system(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;6.14e-09)|all cancers(201;1.66e-07)|BRCA - Breast invasive adenocarcinoma(275;0.224)														---	---	---	---
AS3MT	57412	broad.mit.edu	37	10	104638614	104638614	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104638614C>T	uc001kwk.2	+	9	891	c.751C>T	c.(751-753)CGT>TGT	p.R251C	AS3MT_uc001kwj.2_Missense_Mutation_p.R253C|AS3MT_uc009xxh.2_Missense_Mutation_p.R251C	NM_020682	NP_065733	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	251					arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity				0		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)														---	---	---	---
USMG5	84833	broad.mit.edu	37	10	105151956	105151956	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105151956T>C	uc001kww.1	-	4	435	c.172A>G	c.(172-174)ACA>GCA	p.T58A	USMG5_uc001kwx.1_RNA	NM_032747	NP_116136	Q96IX5	USMG5_HUMAN	upregulated during skeletal muscle growth 5	58						integral to membrane					0		Colorectal(252;0.142)		Epithelial(162;3.94e-09)|all cancers(201;2.76e-08)|BRCA - Breast invasive adenocarcinoma(275;0.197)														---	---	---	---
CALHM1	255022	broad.mit.edu	37	10	105217967	105217967	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105217967C>T	uc001kxe.2	-	1	682	c.542G>A	c.(541-543)CGC>CAC	p.R181H		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	181						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1																		---	---	---	---
C10orf79	80217	broad.mit.edu	37	10	105920859	105920859	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105920859T>C	uc001kxw.2	-	27	3592	c.3476A>G	c.(3475-3477)AAA>AGA	p.K1159R	C10orf79_uc009xxq.2_Missense_Mutation_p.K467R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1159	Potential.										0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)														---	---	---	---
SHOC2	8036	broad.mit.edu	37	10	112769489	112769489	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112769489A>G	uc001kzl.3	+	8	1790	c.1441A>G	c.(1441-1443)AAC>GAC	p.N481D	SHOC2_uc009xxx.2_Missense_Mutation_p.N481D|SHOC2_uc010qrg.1_Missense_Mutation_p.N120D|SHOC2_uc001kzn.2_Missense_Mutation_p.N435D	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	481	LRR 17.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)														---	---	---	---
GPAM	57678	broad.mit.edu	37	10	113935430	113935430	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:113935430A>G	uc009xxy.1	-	6	539	c.341T>C	c.(340-342)TTT>TCT	p.F114S	GPAM_uc001kzp.2_Missense_Mutation_p.F114S|GPAM_uc001kzq.1_Missense_Mutation_p.F114S	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	114					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)														---	---	---	---
GPAM	57678	broad.mit.edu	37	10	113937763	113937763	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:113937763T>C	uc009xxy.1	-	5	476	c.278A>G	c.(277-279)TAT>TGT	p.Y93C	GPAM_uc001kzp.2_Missense_Mutation_p.Y93C|GPAM_uc001kzq.1_Missense_Mutation_p.Y93C	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	93					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)														---	---	---	---
HABP2	3026	broad.mit.edu	37	10	115334171	115334171	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115334171A>G	uc001lai.3	+						HABP2_uc010qrz.1_Intron|HABP2_uc010qry.1_Intron	NM_004132	NP_004123			hyaluronan binding protein 2 preproprotein						cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)														---	---	---	---
CASP7	840	broad.mit.edu	37	10	115451793	115451793	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115451793T>C	uc001lan.2	+						CASP7_uc001lam.2_Intron|CASP7_uc001lao.2_Silent_p.G21G|CASP7_uc001lap.2_5'UTR|CASP7_uc001laq.2_Intron|CASP7_uc010qsa.1_Intron	NM_033339	NP_203125			caspase 7 isoform alpha						activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)														---	---	---	---
TDRD1	56165	broad.mit.edu	37	10	115980582	115980582	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115980582T>C	uc001lbg.1	+	19	2903	c.2750T>C	c.(2749-2751)GTT>GCT	p.V917A	TDRD1_uc001lbf.2_Missense_Mutation_p.V794A|TDRD1_uc001lbh.1_Missense_Mutation_p.V908A|TDRD1_uc001lbi.1_Missense_Mutation_p.V908A|TDRD1_uc010qsc.1_Missense_Mutation_p.V521A|TDRD1_uc001lbj.2_Missense_Mutation_p.V626A	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	917					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)														---	---	---	---
VWA2	340706	broad.mit.edu	37	10	116046098	116046098	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116046098T>C	uc001lbl.1	+	11	1719	c.1398T>C	c.(1396-1398)CGT>CGC	p.R466R	VWA2_uc001lbk.1_Silent_p.R466R|VWA2_uc009xyf.1_Silent_p.R162R	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	466	VWFA 2.					extracellular region		p.R466H(1)		ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)														---	---	---	---
ABLIM1	3983	broad.mit.edu	37	10	116331048	116331048	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116331048G>A	uc010qsg.1	-						ABLIM1_uc010qsh.1_Intron|ABLIM1_uc010qsi.1_Intron|ABLIM1_uc010qsk.1_Intron|ABLIM1_uc009xyp.2_Intron|ABLIM1_uc009xyo.2_Intron	NM_002313	NP_002304			actin-binding LIM protein 1 isoform a						axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)														---	---	---	---
FAM160B1	57700	broad.mit.edu	37	10	116602927	116602927	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116602927T>C	uc001lcb.2	+	6	1093	c.758T>C	c.(757-759)GTT>GCT	p.V253A	FAM160B1_uc001lcc.2_Missense_Mutation_p.V253A	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	253										lung(1)	1																		---	---	---	---
FAM160B1	57700	broad.mit.edu	37	10	116603563	116603563	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116603563G>A	uc001lcb.2	+	7	1215	c.880G>A	c.(880-882)GCG>ACG	p.A294T	FAM160B1_uc001lcc.2_Missense_Mutation_p.A294T	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	294										lung(1)	1																		---	---	---	---
TRUB1	142940	broad.mit.edu	37	10	116731926	116731926	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116731926T>C	uc001lcd.2	+	6	690	c.629T>C	c.(628-630)CTT>CCT	p.L210P	TRUB1_uc010qsl.1_Missense_Mutation_p.L112P	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	210					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)														---	---	---	---
ATRNL1	26033	broad.mit.edu	37	10	116930924	116930924	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116930924C>T	uc001lcg.2	+	8	1608	c.1222C>T	c.(1222-1224)CAG>TAG	p.Q408*	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Nonsense_Mutation_p.Q408*|ATRNL1_uc009xyq.2_Silent_p.S378S	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	408	Kelch 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)														---	---	---	---
GFRA1	2674	broad.mit.edu	37	10	117884972	117884972	+	Missense_Mutation	SNP	G	T	T	rs77730201		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:117884972G>T	uc001lcj.2	-	6	1228	c.530C>A	c.(529-531)CCG>CAG	p.P177Q	GFRA1_uc001lci.2_Missense_Mutation_p.P172Q|GFRA1_uc009xyr.2_Missense_Mutation_p.P172Q	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	177	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)														---	---	---	---
HSPA12A	259217	broad.mit.edu	37	10	118439100	118439100	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118439100C>T	uc001lct.2	-	10	1305	c.1200G>A	c.(1198-1200)CCG>CCA	p.P400P	HSPA12A_uc001lcu.2_Silent_p.P317P	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	400							ATP binding			ovary(1)	1				all cancers(201;0.0158)														---	---	---	---
PDZD8	118987	broad.mit.edu	37	10	119043331	119043331	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119043331T>C	uc001lde.1	-	5	3112	c.2913A>G	c.(2911-2913)ACA>ACG	p.T971T		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	971					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)														---	---	---	---
PDZD8	118987	broad.mit.edu	37	10	119043801	119043801	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119043801G>A	uc001lde.1	-	5	2642	c.2443C>T	c.(2443-2445)CCC>TCC	p.P815S		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	815					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)														---	---	---	---
RAB11FIP2	22841	broad.mit.edu	37	10	119798815	119798815	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:119798815T>C	uc001ldj.1	-	3	1373	c.933A>G	c.(931-933)TTA>TTG	p.L311L	RAB11FIP2_uc009xyz.1_Silent_p.L311L	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	311					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)														---	---	---	---
SFXN4	119559	broad.mit.edu	37	10	120921921	120921921	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:120921921A>G	uc001leb.2	-	3	228	c.183T>C	c.(181-183)AGT>AGC	p.S61S	SFXN4_uc001ldy.2_5'Flank|SFXN4_uc001ldz.2_5'UTR|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	61					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)														---	---	---	---
BAG3	9531	broad.mit.edu	37	10	121436385	121436385	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121436385A>G	uc001lem.2	+	4	1625	c.1319A>G	c.(1318-1320)GAC>GGC	p.D440G	BAG3_uc001lel.2_Missense_Mutation_p.D439G	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	440	BAG.				anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)														---	---	---	---
INPP5F	22876	broad.mit.edu	37	10	121586661	121586661	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121586661T>C	uc001leo.2	+	20	2934	c.2768T>C	c.(2767-2769)GTT>GCT	p.V923A	INPP5F_uc001lep.2_Missense_Mutation_p.V313A	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	923							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)														---	---	---	---
SEC23IP	11196	broad.mit.edu	37	10	121658045	121658045	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121658045T>C	uc001leu.1	+	2	342	c.270T>C	c.(268-270)AGT>AGC	p.S90S	SEC23IP_uc010qtc.1_Intron	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	90	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)														---	---	---	---
PPAPDC1A	196051	broad.mit.edu	37	10	122348907	122348907	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:122348907C>A	uc001lev.1	+	7	1061	c.709C>A	c.(709-711)CCC>ACC	p.P237T	PPAPDC1A_uc009xzl.1_Missense_Mutation_p.P174T|PPAPDC1A_uc001lew.1_3'UTR|PPAPDC1A_uc001lex.1_Missense_Mutation_p.N86K|PPAPDC1A_uc001ley.1_Missense_Mutation_p.P116T	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	237					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)														---	---	---	---
TACC2	10579	broad.mit.edu	37	10	123989903	123989903	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:123989903T>C	uc001lfv.2	+	16	8435	c.8075T>C	c.(8074-8076)CTG>CCG	p.L2692P	TACC2_uc001lfw.2_Missense_Mutation_p.L838P|TACC2_uc009xzx.2_Intron|TACC2_uc010qtv.1_Intron|TACC2_uc001lfx.2_Intron|TACC2_uc001lfy.2_Intron|TACC2_uc001lfz.2_Missense_Mutation_p.L770P|TACC2_uc001lga.2_Intron|TACC2_uc009xzy.2_Intron|TACC2_uc001lgb.2_Intron	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2692	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
TACC2	10579	broad.mit.edu	37	10	124013541	124013541	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124013541C>T	uc001lfv.2	+	23	9177	c.8817C>T	c.(8815-8817)GAC>GAT	p.D2939D	TACC2_uc001lfw.2_Silent_p.D1085D|TACC2_uc009xzx.2_Silent_p.D2817D|TACC2_uc010qtv.1_Silent_p.D2866D|TACC2_uc001lfx.2_Silent_p.D566D|TACC2_uc001lfy.2_Silent_p.D562D|TACC2_uc001lfz.2_Silent_p.D1017D|TACC2_uc001lga.2_Silent_p.D987D|TACC2_uc009xzy.2_Silent_p.D999D|TACC2_uc001lgb.2_Silent_p.D897D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2939	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)																---	---	---	---
DMBT1	1755	broad.mit.edu	37	10	124330458	124330458	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124330458C>T	uc001lgk.1	+						DMBT1_uc001lgl.1_Intron|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Intron|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568			deleted in malignant brain tumors 1 isoform b						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)																---	---	---	---
PSTK	118672	broad.mit.edu	37	10	124742484	124742484	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124742484A>T	uc001lgy.1	+	2	892	c.452A>T	c.(451-453)GAT>GTT	p.D151V		NM_153336	NP_699167	Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	151							ATP binding|kinase activity			liver(1)	1		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)														---	---	---	---
GPR26	2849	broad.mit.edu	37	10	125426428	125426428	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125426428T>C	uc001lhh.2	+	1	558	c.505T>C	c.(505-507)TTC>CTC	p.F169L		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	169	Helical; Name=5; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)																---	---	---	---
GPR26	2849	broad.mit.edu	37	10	125447563	125447563	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125447563T>C	uc001lhh.2	+	3	954	c.901T>C	c.(901-903)TAC>CAC	p.Y301H		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	301	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)																---	---	---	---
GPR26	2849	broad.mit.edu	37	10	125447602	125447602	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125447602C>T	uc001lhh.2	+	3	993	c.940C>T	c.(940-942)CAC>TAC	p.H314Y		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	314	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)																---	---	---	---
CPXM2	119587	broad.mit.edu	37	10	125526528	125526528	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125526528A>G	uc001lhk.1	-	10	1765	c.1440T>C	c.(1438-1440)TAT>TAC	p.Y480Y	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	480					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)														---	---	---	---
CPXM2	119587	broad.mit.edu	37	10	125528175	125528175	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125528175A>G	uc001lhk.1	-	9	1491	c.1166T>C	c.(1165-1167)CTG>CCG	p.L389P	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	389	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)														---	---	---	---
CPXM2	119587	broad.mit.edu	37	10	125601960	125601960	+	Silent	SNP	C	T	T	rs112542031	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:125601960C>T	uc001lhk.1	-	4	883	c.558G>A	c.(556-558)GCG>GCA	p.A186A	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	186	F5/8 type C.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)														---	---	---	---
C10orf137	26098	broad.mit.edu	37	10	127413917	127413917	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127413917T>C	uc001liq.1	+	5	834	c.541T>C	c.(541-543)TAT>CAT	p.Y181H	C10orf137_uc001lin.2_Missense_Mutation_p.Y181H|C10orf137_uc001lio.1_Missense_Mutation_p.Y181H|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)																---	---	---	---
ADAM12	8038	broad.mit.edu	37	10	127730732	127730732	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:127730732T>C	uc001ljk.2	-						ADAM12_uc010qul.1_Intron|ADAM12_uc001ljm.2_Missense_Mutation_p.H729R|ADAM12_uc001ljn.2_Missense_Mutation_p.H726R|ADAM12_uc001ljl.3_Missense_Mutation_p.H728R	NM_003474	NP_003465			ADAM metallopeptidase domain 12 isoform 1						cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)														---	---	---	---
C10orf90	118611	broad.mit.edu	37	10	128192694	128192694	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128192694C>T	uc001ljq.2	-	3	1196	c.1075G>A	c.(1075-1077)GCT>ACT	p.A359T	C10orf90_uc001ljp.2_Missense_Mutation_p.A312T|C10orf90_uc010qum.1_Missense_Mutation_p.A456T|C10orf90_uc009yao.2_Missense_Mutation_p.A456T|C10orf90_uc001ljs.1_Missense_Mutation_p.A312T	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	359										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)												OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DOCK1	1793	broad.mit.edu	37	10	128821470	128821470	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128821470T>C	uc001ljt.2	+	14	1335	c.1271T>C	c.(1270-1272)GTT>GCT	p.V424A	DOCK1_uc010qun.1_Missense_Mutation_p.V445A	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	424	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)														---	---	---	---
FAM196A	642938	broad.mit.edu	37	10	128974139	128974139	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128974139A>G	uc001lju.1	-	1	562	c.521T>C	c.(520-522)GTT>GCT	p.V174A	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Missense_Mutation_p.V174A|FAM196A_uc001ljv.1_Missense_Mutation_p.V174A|FAM196A_uc009yap.1_Missense_Mutation_p.V174A	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	174										ovary(2)	2																		---	---	---	---
PTPRE	5791	broad.mit.edu	37	10	129871635	129871635	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129871635A>G	uc001lkb.2	+	17	1778	c.1499A>G	c.(1498-1500)CAG>CGG	p.Q500R	PTPRE_uc009yat.2_Missense_Mutation_p.Q511R|PTPRE_uc009yau.2_Missense_Mutation_p.Q500R|PTPRE_uc001lkd.2_Missense_Mutation_p.Q442R|PTPRE_uc010quq.1_Missense_Mutation_p.Q401R	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	500	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
MKI67	4288	broad.mit.edu	37	10	129906399	129906399	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129906399A>G	uc001lke.2	-	13	3900	c.3705T>C	c.(3703-3705)GGT>GGC	p.G1235G	MKI67_uc001lkf.2_Silent_p.G875G|MKI67_uc009yav.1_Silent_p.G810G|MKI67_uc009yaw.1_Silent_p.G385G	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1235	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
PWWP2B	170394	broad.mit.edu	37	10	134218153	134218153	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134218153C>T	uc001lll.3	+	2	178	c.149C>T	c.(148-150)CCG>CTG	p.P50L	PWWP2B_uc009ybe.2_Missense_Mutation_p.P50L	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	50											0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	134646945	134646945	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134646945A>G	uc010qux.1	-	42	6212	c.6212T>C	c.(6211-6213)GTG>GCG	p.V2071A		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																														---	---	---	---
GPR123	84435	broad.mit.edu	37	10	134886463	134886463	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134886463C>T	uc001llw.2	+	3	497	c.497C>T	c.(496-498)GCC>GTC	p.A166V				Q86SQ6	GP123_HUMAN	RecName: Full=Probable G-protein coupled receptor 123;	Error:Variant_position_missing_in_Q86SQ6_after_alignment						integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)														---	---	---	---
ADAM8	101	broad.mit.edu	37	10	135076741	135076741	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135076741G>T	uc010qva.1	-						ADAM8_uc010quz.1_Intron|ADAM8_uc009ybi.2_Intron					SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);						integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)														---	---	---	---
TUBGCP2	10844	broad.mit.edu	37	10	135099060	135099060	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135099060C>T	uc001lmg.1	-	12	2152	c.1795G>A	c.(1795-1797)GCG>ACG	p.A599T	TUBGCP2_uc001lmf.1_Missense_Mutation_p.A192T|TUBGCP2_uc010qvc.1_Missense_Mutation_p.A627T|TUBGCP2_uc009ybk.1_Intron|TUBGCP2_uc010qvd.1_Missense_Mutation_p.A469T|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	599					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)														---	---	---	---
CYP2E1	1571	broad.mit.edu	37	10	135346227	135346227	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135346227A>G	uc001lnj.1	+	5	713	c.680A>G	c.(679-681)TAC>TGC	p.Y227C	CYP2E1_uc001lnk.1_Missense_Mutation_p.Y90C|CYP2E1_uc009ybl.1_Missense_Mutation_p.Y28C|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Missense_Mutation_p.Y28C	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	227					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				---	---	---	---
NLRP6	171389	broad.mit.edu	37	11	281524	281524	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:281524C>G	uc010qvs.1	+	4	1790	c.1790C>G	c.(1789-1791)GCC>GGC	p.A597G	NLRP6_uc010qvt.1_Missense_Mutation_p.A597G	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	597						cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)														---	---	---	---
RNH1	6050	broad.mit.edu	37	11	498027	498027	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:498027G>A	uc001lpk.1	-	7	2479	c.1071C>T	c.(1069-1071)GGC>GGT	p.G357G	RNH1_uc001lpl.1_Silent_p.G357G|RNH1_uc001lpm.1_Silent_p.G357G|RNH1_uc001lpn.1_Silent_p.G357G|RNH1_uc001lpo.1_Silent_p.G357G|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Silent_p.G357G|RNH1_uc001lpt.1_Silent_p.G114G|RNH1_uc001lpq.1_Silent_p.G357G|RNH1_uc001lpr.1_Silent_p.G357G|RNH1_uc001lps.1_Silent_p.G357G	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	357	LRR 12.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
RASSF7	8045	broad.mit.edu	37	11	563560	563560	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:563560G>A	uc001lqc.2	+	6	1072	c.1037G>A	c.(1036-1038)GGC>GAC	p.G346D	C11orf35_uc001lpx.2_5'Flank|RASSF7_uc001lqa.2_3'UTR|RASSF7_uc001lqb.2_3'UTR|RASSF7_uc001lqd.2_Nonsense_Mutation_p.W318*	NM_003475	NP_003466	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family	346					regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
RASSF7	8045	broad.mit.edu	37	11	563570	563570	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:563570C>T	uc001lqc.2	+	6	1082	c.1047C>T	c.(1045-1047)GAC>GAT	p.D349D	C11orf35_uc001lpx.2_5'Flank|RASSF7_uc001lqa.2_3'UTR|RASSF7_uc001lqb.2_3'UTR|RASSF7_uc001lqd.2_3'UTR	NM_003475	NP_003466	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family	349					regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
PHRF1	57661	broad.mit.edu	37	11	605153	605153	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:605153C>T	uc001lqe.2	+	11	1318	c.1187C>T	c.(1186-1188)ACG>ATG	p.T396M	PHRF1_uc010qwc.1_Missense_Mutation_p.T396M|PHRF1_uc010qwd.1_Missense_Mutation_p.T395M|PHRF1_uc010qwe.1_Missense_Mutation_p.T392M|PHRF1_uc009ybz.1_Missense_Mutation_p.T187M|PHRF1_uc009yca.1_5'Flank	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	396	Arg-rich.						RNA polymerase binding|zinc ion binding				0																		---	---	---	---
DEAF1	10522	broad.mit.edu	37	11	679734	679734	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:679734G>A	uc001lqq.1	-	8	1773	c.1080C>T	c.(1078-1080)GTC>GTT	p.V360V	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	360					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)														---	---	---	---
CD151	977	broad.mit.edu	37	11	837482	837482	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:837482A>G	uc001lry.2	+	7	623	c.479A>G	c.(478-480)AAC>AGC	p.N160S	CD151_uc001lrx.2_RNA|CD151_uc001lrz.2_Missense_Mutation_p.N160S|CD151_uc001lsa.2_Missense_Mutation_p.N160S|CD151_uc001lsb.2_Missense_Mutation_p.N160S	NM_004357	NP_004348	P48509	CD151_HUMAN	CD151 antigen	160	Extracellular (Potential).				cell adhesion|hemidesmosome assembly	cytosol|integral to plasma membrane|membrane fraction	protein binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.54e-25)|Epithelial(43;1.22e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.91e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
MUC6	4588	broad.mit.edu	37	11	1025234	1025234	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1025234A>C	uc001lsw.2	-	23	2984	c.2933T>G	c.(2932-2934)CTC>CGC	p.L978R		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	978	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
MUC2	4583	broad.mit.edu	37	11	1081139	1081139	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1081139A>G	uc001lsx.1	+	11	1462	c.1435A>G	c.(1435-1437)ACC>GCC	p.T479A		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	479	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)													---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1258211	1258211	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1258211C>A	uc009ycr.1	+	41	5319	c.5193C>A	c.(5191-5193)GCC>GCA	p.A1731A	MUC5B_uc009yct.1_Silent_p.A1038A|MUC5B_uc001ltb.2_Silent_p.A1041A|MUC5B_uc001lta.2_Silent_p.A706A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1038	VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
DUSP8	1850	broad.mit.edu	37	11	1579347	1579347	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1579347A>G	uc001lts.2	-	5	820	c.692T>C	c.(691-693)TTC>TCC	p.F231S		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	231	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)														---	---	---	---
KRTAP5-5	439915	broad.mit.edu	37	11	1651339	1651339	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1651339G>C	uc001lty.2	+	1	307	c.269G>C	c.(268-270)GGC>GCC	p.G90A		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	90	8 X 4 AA repeats of C-C-X-P.					keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)														---	---	---	---
CTSD	1509	broad.mit.edu	37	11	1775320	1775320	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1775320G>T	uc001luc.1	-	7	1009	c.876C>A	c.(874-876)GCC>GCA	p.A292A	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	292					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
H19	283120	broad.mit.edu	37	11	2017345	2017345	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2017345C>T	uc001lvc.1	-	3	1526	c.908G>A	c.(907-909)GGC>GAC	p.G303D	H19_uc001luz.1_RNA|H19_uc001lva.3_RNA|H19_uc001lvd.2_RNA|H19_uc001lve.2_RNA|H19_uc001lvb.1_RNA					SubName: Full=cDNA FLJ32212 fis, clone PLACE6003399, weakly similar to SPIDROIN 1;												0														Beckwith-Wiedemann_syndrome				---	---	---	---
MIR675	100033819	broad.mit.edu	37	11	2018055	2018055	+	RNA	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:2018055C>T	hsa-mir-675|MI0005416	-			c.7C>T			H19_uc001luz.1_5'Flank|H19_uc001lva.3_RNA|H19_uc001lvd.2_RNA|H19_uc001lve.2_RNA|H19_uc001lvb.1_RNA|H19_uc001lvc.1_Silent_p.G131G																	0																OREG0003762|OREG0003763	type=REGULATORY REGION|Gene=H19|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=AF118081|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
OSBPL5	114879	broad.mit.edu	37	11	3141762	3141762	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3141762C>A	uc001lxk.2	-	6	653	c.495G>T	c.(493-495)TGG>TGT	p.W165C	OSBPL5_uc010qxq.1_Intron|OSBPL5_uc009ydw.2_Intron|OSBPL5_uc001lxl.2_Intron|OSBPL5_uc009ydx.2_Missense_Mutation_p.W189C	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	165	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)														---	---	---	---
NUP98	4928	broad.mit.edu	37	11	3744545	3744545	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3744545T>C	uc001lyh.2	-	16	2279	c.1988A>G	c.(1987-1989)AAC>AGC	p.N663S	NUP98_uc001lyi.2_Missense_Mutation_p.N663S|NUP98_uc001lyj.1_Missense_Mutation_p.N663S|NUP98_uc001lyk.1_Missense_Mutation_p.N680S	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	680					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)				T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								---	---	---	---
RRM1	6240	broad.mit.edu	37	11	4150330	4150330	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4150330T>C	uc001lyw.3	+	15	2038	c.1719T>C	c.(1717-1719)GTT>GTC	p.V573V	RRM1_uc009yej.2_RNA|RRM1_uc009yei.2_Silent_p.V533V|RRM1_uc010qyc.1_Silent_p.V476V|RRM1_uc010qyd.1_Silent_p.V235V	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	573					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)													---	---	---	---
RRM1	6240	broad.mit.edu	37	11	4159522	4159522	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4159522T>C	uc001lyw.3	+	19	2607	c.2288T>C	c.(2287-2289)GTA>GCA	p.V763A	RRM1_uc009yej.2_RNA|RRM1_uc009yei.2_Missense_Mutation_p.V723A|RRM1_uc010qyc.1_Missense_Mutation_p.V666A|RRM1_uc010qyd.1_Missense_Mutation_p.V425A	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	763					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)													---	---	---	---
OR52K2	119774	broad.mit.edu	37	11	4471390	4471390	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4471390T>C	uc001lyz.1	+	1	821	c.821T>C	c.(820-822)GTC>GCC	p.V274A		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	274	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR52K1	390036	broad.mit.edu	37	11	4510299	4510299	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4510299C>A	uc001lza.1	+	1	169	c.169C>A	c.(169-171)CTC>ATC	p.L57I		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)														---	---	---	---
OR51E2	81285	broad.mit.edu	37	11	4702990	4702990	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4702990C>A	uc001lzk.2	-	2	1196	c.952G>T	c.(952-954)GGA>TGA	p.G318*		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	318	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)														---	---	---	---
OR51F1	256892	broad.mit.edu	37	11	4790303	4790303	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4790303T>C	uc010qyl.1	-	1	845	c.845A>G	c.(844-846)TAC>TGC	p.Y282C		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	282						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)														---	---	---	---
OR51T1	401665	broad.mit.edu	37	11	4903765	4903765	+	Silent	SNP	C	T	T	rs138268565		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4903765C>T	uc010qyp.1	+	1	717	c.717C>T	c.(715-717)GAC>GAT	p.D239D		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR51G1	79324	broad.mit.edu	37	11	4945549	4945549	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4945549G>A	uc010qyr.1	-	1	21	c.21C>T	c.(19-21)AGC>AGT	p.S7S		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR51A4	401666	broad.mit.edu	37	11	4967443	4967443	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4967443T>C	uc010qys.1	-	1	888	c.888A>G	c.(886-888)AAA>AAG	p.K296K		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR51A4	401666	broad.mit.edu	37	11	4967610	4967610	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4967610T>C	uc010qys.1	-	1	721	c.721A>G	c.(721-723)ACT>GCT	p.T241A		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR51A4	401666	broad.mit.edu	37	11	4967644	4967644	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4967644A>G	uc010qys.1	-	1	687	c.687T>C	c.(685-687)ATT>ATC	p.I229I		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
HBD	3045	broad.mit.edu	37	11	5255572	5255572	+	Missense_Mutation	SNP	C	T	T	rs35654785		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5255572C>T	uc001maf.1	-	1	287	c.92G>A	c.(91-93)AGA>AAA	p.R31K		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	31					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR51B6	390058	broad.mit.edu	37	11	5373179	5373179	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5373179A>G	uc010qzb.1	+	1	442	c.442A>G	c.(442-444)ACA>GCA	p.T148A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR51M1	390059	broad.mit.edu	37	11	5411261	5411261	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5411261A>G	uc010qzc.1	+	1	633	c.633A>G	c.(631-633)GGA>GGG	p.G211G	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	211						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5625792	5625792	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5625792T>G	uc001mbf.2	+	3	780	c.536T>G	c.(535-537)CTG>CGG	p.L179R	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Missense_Mutation_p.L125R|TRIM6_uc010qzj.1_5'UTR|TRIM6_uc001mbc.1_Missense_Mutation_p.L151R|TRIM6_uc001mbe.2_5'UTR|TRIM6_uc010qzk.1_5'UTR|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Missense_Mutation_p.L179R|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	179						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)														---	---	---	---
OR52N5	390075	broad.mit.edu	37	11	5799138	5799138	+	Missense_Mutation	SNP	G	A	A	rs117500523	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5799138G>A	uc010qzn.1	-	1	727	c.727C>T	c.(727-729)CGG>TGG	p.R243W	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	243	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)														---	---	---	---
OR52N1	79473	broad.mit.edu	37	11	5810021	5810021	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5810021A>G	uc010qzo.1	-	1	26	c.26T>C	c.(25-27)CTA>CCA	p.L9P	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)														---	---	---	---
C11orf42	160298	broad.mit.edu	37	11	6232207	6232207	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6232207G>A	uc001mcj.2	+	3	985	c.937G>A	c.(937-939)GAC>AAC	p.D313N		NM_173525	NP_775796	Q8N5U0	CK042_HUMAN	hypothetical protein LOC160298	313										ovary(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
FAM160A2	84067	broad.mit.edu	37	11	6244318	6244318	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6244318C>T	uc001mcl.3	-	4	1287	c.928G>A	c.(928-930)GTA>ATA	p.V310I	FAM160A2_uc001mck.3_Missense_Mutation_p.V310I|FAM160A2_uc001mcm.2_Missense_Mutation_p.V310I	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	310					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2																		---	---	---	---
CNGA4	1262	broad.mit.edu	37	11	6261527	6261527	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6261527G>A	uc001mco.2	+	4	610	c.503G>A	c.(502-504)CGC>CAC	p.R168H	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.R128H	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	168	Extracellular (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
CCKBR	887	broad.mit.edu	37	11	6292348	6292348	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6292348A>G	uc001mcp.2	+	5	1112	c.919A>G	c.(919-921)ACG>GCG	p.T307A	CCKBR_uc001mcq.2_Missense_Mutation_p.T235A|CCKBR_uc001mcr.2_Missense_Mutation_p.T307A|CCKBR_uc001mcs.2_Missense_Mutation_p.T376A|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	307	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)													---	---	---	---
DNHD1	144132	broad.mit.edu	37	11	6540902	6540902	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6540902G>T	uc001mdw.3	+	8	2029	c.1465G>T	c.(1465-1467)GGC>TGC	p.G489C	DNHD1_uc001mdp.2_Missense_Mutation_p.G489C|DNHD1_uc001mdq.2_Missense_Mutation_p.G178C	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	489					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)														---	---	---	---
DNHD1	144132	broad.mit.edu	37	11	6592035	6592035	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6592035C>T	uc001mdw.3	+	42	13857	c.13293C>T	c.(13291-13293)GGC>GGT	p.G4431G	DNHD1_uc001mea.3_Silent_p.G700G|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Silent_p.G699G|DNHD1_uc010rao.1_Silent_p.G689G|DNHD1_uc009yfg.2_Silent_p.G56G	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4431	Potential.				microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)														---	---	---	---
DCHS1	8642	broad.mit.edu	37	11	6662222	6662222	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6662222A>G	uc001mem.1	-	2	1033	c.623T>C	c.(622-624)GTA>GCA	p.V208A		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	208	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
OR2AG2	338755	broad.mit.edu	37	11	6789715	6789715	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6789715T>C	uc001meq.1	-	1	474	c.474A>G	c.(472-474)GGA>GGG	p.G158G		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)														---	---	---	---
OR2D3	120775	broad.mit.edu	37	11	6942479	6942479	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6942479T>C	uc010rav.1	+	1	247	c.247T>C	c.(247-249)TCC>CCC	p.S83P		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	83	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)														---	---	---	---
NLRP14	338323	broad.mit.edu	37	11	7059912	7059912	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7059912T>C	uc001mfb.1	+	2	418	c.95T>C	c.(94-96)TTA>TCA	p.L32S		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	32	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)														---	---	---	---
TUB	7275	broad.mit.edu	37	11	8117104	8117104	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8117104A>T	uc001mga.2	+	5	606	c.457A>T	c.(457-459)ATT>TTT	p.I153F	TUB_uc010rbk.1_Missense_Mutation_p.I159F|TUB_uc001mfy.2_Missense_Mutation_p.I208F	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	153					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)														---	---	---	---
RIC3	79608	broad.mit.edu	37	11	8132264	8132264	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8132264T>C	uc001mgd.2	-	6	1145	c.1091A>G	c.(1090-1092)AAC>AGC	p.N364S	RIC3_uc001mgb.2_Missense_Mutation_p.N202S|RIC3_uc001mgc.2_Missense_Mutation_p.N363S|RIC3_uc001mge.2_Missense_Mutation_p.N182S|RIC3_uc010rbl.1_Missense_Mutation_p.N314S|RIC3_uc010rbm.1_Missense_Mutation_p.N392S|RIC3_uc009yfm.2_Missense_Mutation_p.N283S|RIC3_uc009yfn.2_Missense_Mutation_p.N167S	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	364	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)														---	---	---	---
RPL27A	6157	broad.mit.edu	37	11	8707119	8707119	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8707119A>G	uc001mgs.3	+							NM_000990	NP_000981			ribosomal protein L27a						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				Epithelial(150;3.24e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
ST5	6764	broad.mit.edu	37	11	8732470	8732470	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8732470A>G	uc001mgt.2	-						ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Intron|ST5_uc010rbq.1_Intron|ST5_uc010rbp.1_Intron|ST5_uc009yfs.2_Intron	NM_213618	NP_998783			suppression of tumorigenicity 5 isoform 1						positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)														---	---	---	---
SBF2	81846	broad.mit.edu	37	11	9803113	9803113	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9803113T>C	uc001mib.2	-	39	5530	c.5392A>G	c.(5392-5394)ATC>GTC	p.I1798V	uc001mhz.1_Intron|SBF2_uc001mid.2_Missense_Mutation_p.I442V|SBF2_uc001mic.2_Missense_Mutation_p.I88V|uc001mie.3_Intron	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1798	PH.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)														---	---	---	---
SBF2	81846	broad.mit.edu	37	11	9853940	9853940	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9853940T>C	uc001mib.2	-	27	3621	c.3483A>G	c.(3481-3483)CAA>CAG	p.Q1161Q		NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	1161	Myotubularin phosphatase.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)														---	---	---	---
AMPD3	272	broad.mit.edu	37	11	10518493	10518493	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:10518493T>C	uc001mio.1	+						AMPD3_uc010rbz.1_Intron|AMPD3_uc001min.1_Intron|AMPD3_uc009yfw.1_Intron|AMPD3_uc009yfz.2_Intron|AMPD3_uc001mip.1_Intron|AMPD3_uc009yfy.2_Intron	NM_001025389	NP_001020560			adenosine monophosphate deaminase 3 isoform 1B						AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)														---	---	---	---
USP47	55031	broad.mit.edu	37	11	11927031	11927031	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:11927031A>G	uc001mjq.1	+	9	1728	c.965A>G	c.(964-966)GAC>GGC	p.D322G	USP47_uc001mjr.2_Missense_Mutation_p.D234G|USP47_uc001mjs.2_Missense_Mutation_p.D302G	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	322					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)														---	---	---	---
PARVA	55742	broad.mit.edu	37	11	12530142	12530142	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:12530142A>G	uc001mki.2	+	7	718	c.669A>G	c.(667-669)GGA>GGG	p.G223G	PARVA_uc010rck.1_Silent_p.G170G	NM_018222	NP_060692	Q9NVD7	PARVA_HUMAN	parvin, alpha	223					cell adhesion|cell junction assembly|cilium morphogenesis	actin cytoskeleton|cytosol|focal adhesion	actin binding			breast(3)	3				Epithelial(150;0.00624)														---	---	---	---
RRAS2	22800	broad.mit.edu	37	11	14316397	14316397	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14316397C>T	uc001mlf.3	-	3	521	c.208G>A	c.(208-210)GCA>ACA	p.A70T	RRAS2_uc009ygq.2_5'UTR|RRAS2_uc010rco.1_Missense_Mutation_p.A76T	NM_012250	NP_036382	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	70	GTP (By similarity).					endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)	1				Epithelial(150;0.203)														---	---	---	---
COPB1	1315	broad.mit.edu	37	11	14486521	14486521	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14486521G>A	uc001mli.2	-	18	2653	c.2346C>T	c.(2344-2346)TTC>TTT	p.F782F	COPB1_uc001mlg.2_Silent_p.F782F|COPB1_uc001mlh.2_Silent_p.F782F	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	782					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
COPB1	1315	broad.mit.edu	37	11	14515965	14515965	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14515965T>A	uc001mli.2	-	3	419	c.112A>T	c.(112-114)AAG>TAG	p.K38*	COPB1_uc001mlg.2_Nonsense_Mutation_p.K38*|COPB1_uc001mlh.2_Nonsense_Mutation_p.K38*|PSMA1_uc010rcp.1_RNA	NM_016451	NP_057535	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	38					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
PDE3B	5140	broad.mit.edu	37	11	14839924	14839924	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14839924G>A	uc001mln.2	+	6	2071	c.1718G>A	c.(1717-1719)AGC>AAC	p.S573N	PDE3B_uc010rcr.1_Missense_Mutation_p.S522N	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	573					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0																		---	---	---	---
CYP2R1	120227	broad.mit.edu	37	11	14913534	14913534	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14913534T>C	uc001mlr.2	-	1	218	c.218A>G	c.(217-219)TAC>TGC	p.Y73C	CYP2R1_uc001mlo.2_5'Flank|CYP2R1_uc001mlp.2_5'Flank|CYP2R1_uc001mlq.2_5'Flank	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	73					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)													---	---	---	---
KCNJ11	3767	broad.mit.edu	37	11	17409176	17409176	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17409176C>T	uc001mna.2	-	1	1031	c.463G>A	c.(463-465)GTG>ATG	p.V155M	KCNJ11_uc001mnb.3_Missense_Mutation_p.V68M	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	155						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)												OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17531325	17531325	+	Intron	SNP	G	A	A	rs140528164	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17531325G>A	uc001mnf.2	-						USH1C_uc001mne.2_Missense_Mutation_p.R531C|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
USH1C	10083	broad.mit.edu	37	11	17531971	17531971	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17531971G>A	uc001mnf.2	-						USH1C_uc001mne.2_Missense_Mutation_p.A504V|USH1C_uc009yhb.2_Intron|USH1C_uc001mng.2_Intron|USH1C_uc001mnd.2_Intron	NM_005709	NP_005700			harmonin isoform a						equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1																		---	---	---	---
NAV2	89797	broad.mit.edu	37	11	20122663	20122663	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20122663G>A	uc001mpr.3	+	32	6732	c.6371G>A	c.(6370-6372)CGG>CAG	p.R2124Q	NAV2_uc001mpp.2_Missense_Mutation_p.R2057Q|NAV2_uc009yhx.2_Missense_Mutation_p.R1185Q|NAV2_uc009yhz.2_Missense_Mutation_p.R766Q|NAV2_uc001mpu.2_Missense_Mutation_p.R559Q	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	2180						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6																		---	---	---	---
SLC6A5	9152	broad.mit.edu	37	11	20629055	20629055	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20629055T>C	uc001mqd.2	+	5	1115	c.842T>C	c.(841-843)GTC>GCC	p.V281A	SLC6A5_uc009yic.2_Missense_Mutation_p.V46A	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	281	Helical; Name=3; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)													---	---	---	---
ANO5	203859	broad.mit.edu	37	11	22276909	22276909	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:22276909A>G	uc001mqi.2	+						ANO5_uc001mqj.2_Intron	NM_213599	NP_998764			anoctamin 5 isoform a							chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
MUC15	143662	broad.mit.edu	37	11	26587159	26587159	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26587159C>T	uc001mqx.2	-	2	513	c.247G>A	c.(247-249)GGA>AGA	p.G83R	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.G110R|MUC15_uc001mqy.2_Missense_Mutation_p.G110R	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	83	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
SLC5A12	159963	broad.mit.edu	37	11	26734184	26734184	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26734184T>C	uc001mra.2	-						SLC5A12_uc001mrb.2_Intron|SLC5A12_uc001mrc.3_Intron	NM_178498	NP_848593			solute carrier family 5 (sodium/glucose						sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			ovary(1)|skin(1)	2																		---	---	---	---
FIBIN	387758	broad.mit.edu	37	11	27016599	27016599	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:27016599A>G	uc001mrd.2	+	1	972	c.526A>G	c.(526-528)ACA>GCA	p.T176A		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	176						extracellular region|Golgi apparatus					0																		---	---	---	---
BBOX1	8424	broad.mit.edu	37	11	27141369	27141369	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:27141369A>G	uc001mre.1	+	7	1181	c.813A>G	c.(811-813)GTA>GTG	p.V271V	BBOX1_uc009yih.1_Silent_p.V271V|BBOX1_uc001mrg.1_Silent_p.V271V	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	271					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
KCNA4	3739	broad.mit.edu	37	11	30032677	30032677	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30032677A>G	uc001msk.2	-	2	2701	c.1549T>C	c.(1549-1551)TGG>CGG	p.W517R		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	517						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
DCDC1	341019	broad.mit.edu	37	11	31312290	31312290	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31312290T>C	uc001msv.2	-	7	1066	c.864A>G	c.(862-864)AAA>AAG	p.K288K	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	288					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)																	---	---	---	---
PAX6	5080	broad.mit.edu	37	11	31824298	31824298	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:31824298A>G	uc001mtd.3	-	4	985	c.95T>C	c.(94-96)CTA>CCA	p.L32P	PAX6_uc001mte.3_Missense_Mutation_p.L32P|PAX6_uc001mtg.3_Missense_Mutation_p.L32P|PAX6_uc001mtf.3_Missense_Mutation_p.L32P|PAX6_uc001mth.3_Missense_Mutation_p.L32P|PAX6_uc009yjr.2_Missense_Mutation_p.L32P	NM_001127612	NP_001121084	P26367	PAX6_HUMAN	paired box gene 6 isoform a	32	Paired.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			lung(4)|ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	9	Lung SC(675;0.225)													Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				---	---	---	---
RCN1	5954	broad.mit.edu	37	11	32118854	32118854	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:32118854A>G	uc010reb.1	+	2	685	c.419A>G	c.(418-420)TAC>TGC	p.Y140C	RCN1_uc010rea.1_Missense_Mutation_p.Y89C|RCN1_uc001mtk.2_Translation_Start_Site	NM_002901	NP_002892	Q15293	RCN1_HUMAN	reticulocalbin 1 precursor	140	EF-hand 2.					endoplasmic reticulum lumen	calcium ion binding			large_intestine(1)	1	Lung SC(675;0.225)																	---	---	---	---
CCDC73	493860	broad.mit.edu	37	11	32635338	32635338	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:32635338A>G	uc001mtv.2	-	16	2570	c.2526T>C	c.(2524-2526)AAT>AAC	p.N842N		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	842										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)																	---	---	---	---
TCP11L1	55346	broad.mit.edu	37	11	33087372	33087372	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33087372A>G	uc001mud.2	+						TCP11L1_uc009yju.2_Intron|TCP11L1_uc010rei.1_Intron|TCP11L1_uc001mue.2_Intron|TCP11L1_uc001muf.1_Intron	NM_018393	NP_060863			t-complex 11 (mouse) like 1												0																OREG0020866	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CSTF3	1479	broad.mit.edu	37	11	33113893	33113893	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33113893T>C	uc001muh.2	-						TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317			cleavage stimulation factor subunit 3 isoform 1						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0																		---	---	---	---
FBXO3	26273	broad.mit.edu	37	11	33780074	33780074	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33780074A>G	uc001muz.2	-	4	460	c.432T>C	c.(430-432)TGT>TGC	p.C144C	FBXO3_uc001muy.2_Silent_p.C31C|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Silent_p.C144C|FBXO3_uc001mvb.1_Silent_p.C139C|FBXO3_uc010rek.1_RNA	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	144					proteolysis	nucleus	ubiquitin-protein ligase activity			pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)														---	---	---	---
EHF	26298	broad.mit.edu	37	11	34680429	34680429	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34680429T>C	uc001mvr.1	+	9	965	c.854T>C	c.(853-855)GTA>GCA	p.V285A	EHF_uc009yke.1_Missense_Mutation_p.V262A|EHF_uc009ykf.1_Missense_Mutation_p.V288A	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	285	ETS.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)															---	---	---	---
PDHX	8050	broad.mit.edu	37	11	34991757	34991757	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34991757T>C	uc001mvt.2	+	7	1414	c.888T>C	c.(886-888)AGT>AGC	p.S296S	PDHX_uc010rep.1_Silent_p.S281S|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	296					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)															---	---	---	---
FJX1	24147	broad.mit.edu	37	11	35641182	35641182	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:35641182C>T	uc001mwh.2	+	1	1448	c.998C>T	c.(997-999)GCG>GTG	p.A333V		NM_014344	NP_055159	Q86VR8	FJX1_HUMAN	four jointed box 1 precursor	333						extracellular space					0	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)																---	---	---	---
LRRC4C	57689	broad.mit.edu	37	11	40136377	40136377	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:40136377A>G	uc001mxa.1	-	2	3430	c.1466T>C	c.(1465-1467)GTG>GCG	p.V489A	LRRC4C_uc001mxc.1_Missense_Mutation_p.V485A|LRRC4C_uc001mxd.1_Missense_Mutation_p.V485A|LRRC4C_uc001mxb.1_Missense_Mutation_p.V485A	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	489					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)																---	---	---	---
API5	8539	broad.mit.edu	37	11	43363975	43363975	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43363975T>C	uc010rfh.1	+						API5_uc010rfg.1_Intron|API5_uc001mxf.2_Intron|API5_uc010rfi.1_Intron	NM_001142930	NP_001136402			apoptosis inhibitor 5 isoform a						anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
TTC17	55761	broad.mit.edu	37	11	43427103	43427103	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:43427103A>G	uc001mxi.2	+	12	1533	c.1519A>G	c.(1519-1521)ACA>GCA	p.T507A	TTC17_uc001mxh.2_Missense_Mutation_p.T507A|TTC17_uc010rfj.1_Missense_Mutation_p.T450A|TTC17_uc001mxj.2_Missense_Mutation_p.T277A	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	507							binding			ovary(5)	5																		---	---	---	---
ACCSL	390110	broad.mit.edu	37	11	44072889	44072889	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44072889C>T	uc001mxw.1	+	4	696	c.640C>T	c.(640-642)CGG>TGG	p.R214W	ACCSL_uc009ykr.2_Missense_Mutation_p.R33W	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	214							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5																		---	---	---	---
CHST1	8534	broad.mit.edu	37	11	45671419	45671419	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45671419T>C	uc001mys.1	-	4	1726	c.1055A>G	c.(1054-1056)AAC>AGC	p.N352S		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	352	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)														---	---	---	---
MAPK8IP1	9479	broad.mit.edu	37	11	45923617	45923617	+	Intron	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45923617G>C	uc001nbr.2	+							NM_005456	NP_005447			mitogen-activated protein kinase 8 interacting						vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)														---	---	---	---
GYLTL1B	120071	broad.mit.edu	37	11	45947887	45947887	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45947887T>C	uc001nbv.1	+	8	1108	c.997T>C	c.(997-999)TCT>CCT	p.S333P	GYLTL1B_uc001nbw.1_Missense_Mutation_p.S302P|GYLTL1B_uc001nbx.1_Missense_Mutation_p.S333P|GYLTL1B_uc001nby.1_5'Flank|GYLTL1B_uc001nbz.1_5'Flank	NM_152312	NP_689525	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	333	Lumenal (Potential).				muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.226)														---	---	---	---
PHF21A	51317	broad.mit.edu	37	11	45992799	45992799	+	Silent	SNP	G	A	A	rs148927461		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45992799G>A	uc001ncc.3	-	7	1104	c.480C>T	c.(478-480)ACC>ACT	p.T160T	PHF21A_uc001ncb.3_Silent_p.T160T|PHF21A_uc009ykx.2_Silent_p.T160T|PHF21A_uc001nce.2_Silent_p.T160T|PHF21A_uc001nca.1_5'UTR	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	160					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
AMBRA1	55626	broad.mit.edu	37	11	46564329	46564329	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46564329C>A	uc010rgu.1	-	7	1598	c.1238G>T	c.(1237-1239)GGG>GTG	p.G413V	AMBRA1_uc010rgt.1_5'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.G413V|AMBRA1_uc001ncu.1_Missense_Mutation_p.G323V|AMBRA1_uc001ncv.2_Missense_Mutation_p.G323V|AMBRA1_uc001ncw.2_Missense_Mutation_p.G323V|AMBRA1_uc001ncx.2_Missense_Mutation_p.G413V	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	413					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)														---	---	---	---
ZNF408	79797	broad.mit.edu	37	11	46727107	46727107	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46727107G>A	uc001nde.1	+	5	2087	c.1857G>A	c.(1855-1857)CCG>CCA	p.P619P	ZNF408_uc010rgw.1_Silent_p.P611P	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	619	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0																		---	---	---	---
F2	2147	broad.mit.edu	37	11	46747671	46747671	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46747671C>T	uc001ndf.3	+	7	865	c.822C>T	c.(820-822)TGC>TGT	p.C274C	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	274	Kringle 2.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)													---	---	---	---
F2	2147	broad.mit.edu	37	11	46747718	46747718	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46747718A>G	uc001ndf.3	+	7	912	c.869A>G	c.(868-870)TAT>TGT	p.Y290C	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	290	Kringle 2.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)													---	---	---	---
CKAP5	9793	broad.mit.edu	37	11	46765729	46765729	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46765729T>C	uc001ndi.1	-	44	6053	c.5943A>G	c.(5941-5943)AAA>AAG	p.K1981K	CKAP5_uc009ylg.1_Silent_p.K1874K|CKAP5_uc001ndj.1_Silent_p.K1921K|CKAP5_uc001ndh.1_Silent_p.K910K	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1981					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
ARFGAP2	84364	broad.mit.edu	37	11	47187811	47187811	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47187811A>G	uc001ndt.2	-						ARFGAP2_uc010rha.1_Intron|ARFGAP2_uc010rhb.1_Intron|ARFGAP2_uc001ndu.2_Intron|ARFGAP2_uc010rhc.1_Intron	NM_032389	NP_115765			ADP-ribosylation factor GTPase activating						protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1																		---	---	---	---
PACSIN3	29763	broad.mit.edu	37	11	47203980	47203980	+	Missense_Mutation	SNP	C	T	T	rs147642333	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47203980C>T	uc001ndw.2	-	4	523	c.185G>A	c.(184-186)CGA>CAA	p.R62Q	PACSIN3_uc001ndx.2_Missense_Mutation_p.R62Q|PACSIN3_uc001ndy.2_Missense_Mutation_p.R62Q|PACSIN3_uc001ndz.2_RNA|PACSIN3_uc001nea.2_RNA	NM_016223	NP_057307	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in	62	FCH.				endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding				0																		---	---	---	---
SLC39A13	91252	broad.mit.edu	37	11	47436421	47436421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47436421G>A	uc009ylq.2	+	8	1051	c.880G>A	c.(880-882)GCT>ACT	p.A294T	SLC39A13_uc001nfd.2_3'UTR|SLC39A13_uc001nfe.1_RNA|SLC39A13_uc001nff.3_Missense_Mutation_p.A294T|SLC39A13_uc001nfg.3_Missense_Mutation_p.A294T	NM_001128225	NP_001121697	Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter),	294	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				Lung(87;0.0936)														---	---	---	---
AGBL2	79841	broad.mit.edu	37	11	47681718	47681718	+	3'UTR	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47681718G>T	uc001ngg.2	-	18					AGBL2_uc001ngf.2_RNA	NM_024783	NP_079059			carboxypeptidase 2, cytosolic						proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
NUP160	23279	broad.mit.edu	37	11	47837550	47837550	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47837550T>G	uc001ngm.2	-	12	1548	c.1463A>C	c.(1462-1464)GAT>GCT	p.D488A	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	488					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
PTPRJ	5795	broad.mit.edu	37	11	48152056	48152056	+	Missense_Mutation	SNP	C	T	T	rs140690947	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48152056C>T	uc001ngp.3	+	8	1758	c.1403C>T	c.(1402-1404)ACG>ATG	p.T468M	PTPRJ_uc001ngo.3_Missense_Mutation_p.T468M	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	468	Extracellular (Potential).|Fibronectin type-III 5.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8																		---	---	---	---
OR4C3	256144	broad.mit.edu	37	11	48347301	48347301	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48347301T>C	uc010rhv.1	+	1	809	c.809T>C	c.(808-810)ATT>ACT	p.I270T		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49197411	49197411	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49197411T>C	uc001ngy.2	-	8	1280	c.1019A>G	c.(1018-1020)CAA>CGA	p.Q340R	FOLH1_uc001ngz.2_Missense_Mutation_p.Q340R|FOLH1_uc009yly.2_Missense_Mutation_p.Q325R|FOLH1_uc009ylz.2_Missense_Mutation_p.Q325R|FOLH1_uc009yma.2_Missense_Mutation_p.Q32R	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	340	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
OR4C46	119749	broad.mit.edu	37	11	51515506	51515506	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:51515506T>C	uc010ric.1	+	1	225	c.225T>C	c.(223-225)AAT>AAC	p.N75N		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	75	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
OR4A15	81328	broad.mit.edu	37	11	55135662	55135662	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55135662T>C	uc010rif.1	+	1	303	c.303T>C	c.(301-303)TAT>TAC	p.Y101Y		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	101	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
OR4C16	219428	broad.mit.edu	37	11	55339775	55339775	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55339775T>G	uc010rih.1	+	1	172	c.172T>G	c.(172-174)TTC>GTC	p.F58V		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)																---	---	---	---
OR4C11	219429	broad.mit.edu	37	11	55371683	55371683	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55371683G>T	uc010rii.1	-	1	167	c.167C>A	c.(166-168)CCC>CAC	p.P56H		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
OR5W2	390148	broad.mit.edu	37	11	55681578	55681578	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55681578T>C	uc010rir.1	-	1	481	c.481A>G	c.(481-483)ACA>GCA	p.T161A		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
OR5AS1	219447	broad.mit.edu	37	11	55798339	55798339	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55798339T>C	uc010riw.1	+	1	445	c.445T>C	c.(445-447)TAT>CAT	p.Y149H		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)																	---	---	---	---
OR8I2	120586	broad.mit.edu	37	11	55861664	55861664	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55861664A>G	uc010rix.1	+	1	881	c.881A>G	c.(880-882)AAA>AGA	p.K294R		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	294	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)																	---	---	---	---
OR8H3	390152	broad.mit.edu	37	11	55890420	55890420	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55890420A>G	uc001nii.1	+	1	572	c.572A>G	c.(571-573)GAC>GGC	p.D191G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)																	---	---	---	---
OR8J3	81168	broad.mit.edu	37	11	55904915	55904915	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55904915A>T	uc010riz.1	-	1	280	c.280T>A	c.(280-282)TTC>ATC	p.F94I		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)																	---	---	---	---
OR5J2	282775	broad.mit.edu	37	11	55944776	55944776	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55944776T>G	uc010rjb.1	+	1	683	c.683T>G	c.(682-684)ATC>AGC	p.I228S		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)																	---	---	---	---
OR5T1	390155	broad.mit.edu	37	11	56043602	56043602	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56043602C>T	uc001nio.1	+	1	488	c.488C>T	c.(487-489)GCT>GTT	p.A163V		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	163	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)																	---	---	---	---
OR8J1	219477	broad.mit.edu	37	11	56128242	56128242	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56128242A>G	uc010rjh.1	+	1	520	c.520A>G	c.(520-522)ATC>GTC	p.I174V		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---
OR8J1	219477	broad.mit.edu	37	11	56128506	56128506	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56128506C>G	uc010rjh.1	+	1	784	c.784C>G	c.(784-786)CCC>GCC	p.P262A		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)																	---	---	---	---
APLNR	187	broad.mit.edu	37	11	57003976	57003976	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57003976C>T	uc001njo.2	-	1	952	c.503G>A	c.(502-504)CGC>CAC	p.R168H	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	168	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6																		---	---	---	---
SLC43A3	29015	broad.mit.edu	37	11	57182546	57182546	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57182546C>T	uc001nkg.2	-	10	1213	c.803G>A	c.(802-804)CGC>CAC	p.R268H	PRG2_uc001nke.2_Missense_Mutation_p.R167H|SLC43A3_uc001nkh.2_Missense_Mutation_p.R268H|SLC43A3_uc010rjr.1_Missense_Mutation_p.R281H|SLC43A3_uc009yme.2_Missense_Mutation_p.R268H|SLC43A3_uc001nki.2_Missense_Mutation_p.R268H|SLC43A3_uc009ymf.1_Missense_Mutation_p.R268H	NM_014096	NP_054815	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	268					transmembrane transport	integral to membrane				central_nervous_system(1)	1																		---	---	---	---
UBE2L6	9246	broad.mit.edu	37	11	57319863	57319863	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57319863T>C	uc001nkn.1	-	4	526	c.430A>G	c.(430-432)ACC>GCC	p.T144A	UBE2L6_uc001nko.1_Missense_Mutation_p.T78A	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	144					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
CLP1	10978	broad.mit.edu	37	11	57428563	57428563	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57428563T>C	uc001nkw.2	+	3	1072	c.933T>C	c.(931-933)TGT>TGC	p.C311C	CLP1_uc010rjw.1_Silent_p.C247C|CLP1_uc009yml.2_Silent_p.C311C	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	311					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1																		---	---	---	---
ZDHHC5	25921	broad.mit.edu	37	11	57466793	57466793	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57466793C>A	uc001nkx.1	+	11	3141	c.1885C>A	c.(1885-1887)CCA>ACA	p.P629T	ZDHHC5_uc001nky.1_Missense_Mutation_p.P576T|ZDHHC5_uc001nkz.1_Missense_Mutation_p.P443T	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	629						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1																		---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57564331	57564331	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57564331T>C	uc001nmc.3	+	6	1394	c.823T>C	c.(823-825)TTT>CTT	p.F275L	CTNND1_uc001nlf.1_Missense_Mutation_p.F275L|CTNND1_uc001nlh.1_Missense_Mutation_p.F275L|CTNND1_uc001nlu.3_Missense_Mutation_p.F174L|CTNND1_uc001nlt.3_Missense_Mutation_p.F174L|CTNND1_uc001nls.3_Missense_Mutation_p.F174L|CTNND1_uc001nlw.3_Missense_Mutation_p.F174L|CTNND1_uc001nmf.3_Missense_Mutation_p.F275L|CTNND1_uc001nmd.3_Missense_Mutation_p.F221L|CTNND1_uc001nlk.3_Missense_Mutation_p.F221L|CTNND1_uc001nme.3_Missense_Mutation_p.F275L|CTNND1_uc001nll.3_Missense_Mutation_p.F221L|CTNND1_uc001nmg.3_Missense_Mutation_p.F221L|CTNND1_uc001nlj.3_Missense_Mutation_p.F221L|CTNND1_uc001nlr.3_Missense_Mutation_p.F221L|CTNND1_uc001nlp.3_Missense_Mutation_p.F221L|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Missense_Mutation_p.F275L|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Missense_Mutation_p.F174L|CTNND1_uc001nmh.3_Missense_Mutation_p.F275L|CTNND1_uc001nlq.3_Missense_Mutation_p.F174L|CTNND1_uc001nln.3_Missense_Mutation_p.F275L|CTNND1_uc001nli.3_Missense_Mutation_p.F275L|CTNND1_uc001nlo.3_Missense_Mutation_p.F174L|CTNND1_uc001nlv.3_Missense_Mutation_p.F174L	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	275					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
OR9I1	219954	broad.mit.edu	37	11	57886082	57886082	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57886082T>C	uc001nml.1	-	1	835	c.835A>G	c.(835-837)ACA>GCA	p.T279A	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)																---	---	---	---
OR9Q2	219957	broad.mit.edu	37	11	57958080	57958080	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57958080T>C	uc010rka.1	+	1	118	c.118T>C	c.(118-120)TTA>CTA	p.L40L		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)																---	---	---	---
OR10Q1	219960	broad.mit.edu	37	11	57995544	57995544	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57995544C>T	uc010rkd.1	-	1	804	c.804G>A	c.(802-804)CGG>CGA	p.R268R		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)																---	---	---	---
OR5B3	441608	broad.mit.edu	37	11	58170499	58170499	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58170499T>A	uc010rkf.1	-	1	384	c.384A>T	c.(382-384)CTA>CTT	p.L128L		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)																---	---	---	---
OR5B2	390190	broad.mit.edu	37	11	58190667	58190667	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:58190667A>C	uc010rkg.1	-	1	68	c.68T>G	c.(67-69)ATC>AGC	p.I23S		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)																---	---	---	---
OR4D9	390199	broad.mit.edu	37	11	59283042	59283042	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59283042G>A	uc010rkv.1	+	1	657	c.657G>A	c.(655-657)ACG>ACA	p.T219T		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
PATL1	219988	broad.mit.edu	37	11	59419930	59419930	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59419930A>G	uc001noe.3	-						PATL1_uc009yms.1_Intron|PATL1_uc010rkw.1_Intron	NM_152716	NP_689929			protein associated with topoisomerase II homolog						cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1																		---	---	---	---
PATL1	219988	broad.mit.edu	37	11	59424057	59424057	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59424057G>T	uc001noe.3	-	6	781	c.638C>A	c.(637-639)CCT>CAT	p.P213H	PATL1_uc009yms.1_Missense_Mutation_p.P213H|PATL1_uc010rkw.1_Intron	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	213	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1																		---	---	---	---
PATL1	219988	broad.mit.edu	37	11	59425039	59425039	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59425039T>C	uc001noe.3	-	5	728	c.585A>G	c.(583-585)CCA>CCG	p.P195P	PATL1_uc009yms.1_Silent_p.P195P|PATL1_uc010rkw.1_Intron	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	195	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1																		---	---	---	---
MRPL16	54948	broad.mit.edu	37	11	59574011	59574011	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59574011C>T	uc001noh.2	-	4	779	c.565G>A	c.(565-567)GCT>ACT	p.A189T		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	189							rRNA binding			central_nervous_system(1)	1																		---	---	---	---
MS4A10	341116	broad.mit.edu	37	11	60557963	60557963	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60557963A>G	uc001npz.1	+	2	251	c.155A>G	c.(154-156)AAG>AGG	p.K52R		NM_206893	NP_996776	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member	52	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|skin(1)	2																		---	---	---	---
TMEM109	79073	broad.mit.edu	37	11	60689377	60689377	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60689377C>T	uc001nqg.2	+	4	850	c.472C>T	c.(472-474)CGG>TGG	p.R158W	TMEM109_uc001nqh.2_Missense_Mutation_p.R158W|TMEM132A_uc001nqi.2_5'Flank|TMEM132A_uc001nqj.2_5'Flank	NM_024092	NP_076997	Q9BVC6	TM109_HUMAN	transmembrane protein 109 precursor	158						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane					0																		---	---	---	---
TMEM132A	54972	broad.mit.edu	37	11	60704386	60704386	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60704386A>G	uc001nqj.2	+	11					TMEM132A_uc001nqi.2_3'UTR|TMEM132A_uc001nqm.2_3'UTR	NM_178031	NP_821174			transmembrane protein 132A isoform b							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1																		---	---	---	---
CD6	923	broad.mit.edu	37	11	60781400	60781400	+	Missense_Mutation	SNP	T	C	C	rs112948328		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60781400T>C	uc001nqq.2	+	8	1524	c.1301T>C	c.(1300-1302)GTA>GCA	p.V434A	CD6_uc001nqp.2_Missense_Mutation_p.V434A|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.V434A	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	434	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1																		---	---	---	---
PGA3	643834	broad.mit.edu	37	11	60971733	60971733	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60971733T>A	uc001nqx.2	+	2	264	c.211T>A	c.(211-213)TAC>AAC	p.Y71N	PGA3_uc010rld.1_Missense_Mutation_p.Y71N	NM_001079807	NP_001073275			pepsinogen 3, group I precursor											ovary(1)|skin(1)	2																		---	---	---	---
DAK	26007	broad.mit.edu	37	11	61106890	61106890	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61106890A>C	uc001nre.2	+	5	726	c.469A>C	c.(469-471)ACG>CCG	p.T157P	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_Missense_Mutation_p.T87P	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	157	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0																		---	---	---	---
DAK	26007	broad.mit.edu	37	11	61111397	61111397	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61111397G>A	uc001nre.2	+	12	1309	c.1052G>A	c.(1051-1053)CGG>CAG	p.R351Q	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Missense_Mutation_p.R281Q	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	351					glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0																		---	---	---	---
DAGLA	747	broad.mit.edu	37	11	61511005	61511005	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61511005A>G	uc001nsa.2	+	20	2284	c.2173A>G	c.(2173-2175)AGC>GGC	p.S725G		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	725	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)														---	---	---	---
RAB3IL1	5866	broad.mit.edu	37	11	61675578	61675578	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61675578A>T	uc001nso.2	-	2	370	c.212T>A	c.(211-213)ATC>AAC	p.I71N	RAB3IL1_uc001nsp.2_Missense_Mutation_p.I118N	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	71							protein binding			skin(2)|central_nervous_system(1)	3																		---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62285758	62285758	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62285758A>G	uc001ntl.2	-	5	16431	c.16131T>C	c.(16129-16131)TCT>TCC	p.S5377S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5377					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62297276	62297276	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62297276T>C	uc001ntl.2	-	5	4913	c.4613A>G	c.(4612-4614)GAC>GGC	p.D1538G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1538					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
AHNAK	79026	broad.mit.edu	37	11	62299953	62299953	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62299953G>A	uc001ntl.2	-	5	2236	c.1936C>T	c.(1936-1938)CCA>TCA	p.P646S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	646					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)																---	---	---	---
TUT1	64852	broad.mit.edu	37	11	62342880	62342880	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62342880A>G	uc001nto.2	-	9	2463	c.2425T>C	c.(2425-2427)TGG>CGG	p.W809R	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|EEF1G_uc001ntn.1_5'Flank|TUT1_uc001ntp.1_Missense_Mutation_p.W305R	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	771					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
MTA2	9219	broad.mit.edu	37	11	62364226	62364226	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62364226C>A	uc001ntq.1	-	9	1146	c.765G>T	c.(763-765)CAG>CAT	p.Q255H	MTA2_uc010rlx.1_Missense_Mutation_p.Q82H	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	255	ELM2.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
GANAB	23193	broad.mit.edu	37	11	62397917	62397917	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62397917G>T	uc001nub.2	-	12	1480	c.1447C>A	c.(1447-1449)CTG>ATG	p.L483M	GANAB_uc001nua.2_Missense_Mutation_p.L505M|GANAB_uc001nuc.2_Missense_Mutation_p.L386M|GANAB_uc010rma.1_Missense_Mutation_p.L391M|GANAB_uc010rmb.1_Missense_Mutation_p.L369M	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	483					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
INTS5	80789	broad.mit.edu	37	11	62417003	62417003	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62417003A>G	uc001nud.2	-	2	602	c.549T>C	c.(547-549)TGT>TGC	p.C183C	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	183					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2																		---	---	---	---
C11orf83	790955	broad.mit.edu	37	11	62439509	62439509	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62439509A>G	uc001nui.3	+	2	297	c.205A>G	c.(205-207)ACC>GCC	p.T69A	C11orf48_uc001nue.2_5'Flank|C11orf48_uc001nuf.2_5'Flank|C11orf48_uc010rmd.1_5'Flank	NM_001085372	NP_001078841	Q6UW78	CK083_HUMAN	hypothetical protein LOC790955 precursor	69						extracellular region					0																		---	---	---	---
UBXN1	51035	broad.mit.edu	37	11	62446168	62446168	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62446168A>G	uc001nul.1	-	2	239	c.107T>C	c.(106-108)ATG>ACG	p.M36T	UBXN1_uc001nuj.2_Missense_Mutation_p.M36T|UBXN1_uc001num.1_Missense_Mutation_p.M36T|UBXN1_uc001nuk.2_Missense_Mutation_p.M1T|UBXN1_uc010rme.1_Missense_Mutation_p.M36T|UBXN1_uc010rmf.1_Missense_Mutation_p.M36T	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	36	UBA.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0																		---	---	---	---
ZBTB3	79842	broad.mit.edu	37	11	62520195	62520195	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62520195T>G	uc001nuz.2	-	2	1214	c.1092A>C	c.(1090-1092)GAA>GAC	p.E364D		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3																		---	---	---	---
SLC22A6	9356	broad.mit.edu	37	11	62751091	62751091	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62751091T>C	uc001nwk.2	-	3	853	c.546A>G	c.(544-546)GCA>GCG	p.A182A	SLC22A6_uc001nwl.2_Silent_p.A182A|SLC22A6_uc001nwj.2_Silent_p.A182A|SLC22A6_uc001nwm.2_Silent_p.A182A	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	182	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0																		---	---	---	---
SLC22A25	387601	broad.mit.edu	37	11	62931516	62931516	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62931516A>G	uc001nwr.1	-	9	1424	c.1424T>C	c.(1423-1425)TTT>TCT	p.F475S	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	475	Helical; Name=11; (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4																		---	---	---	---
RTN3	10313	broad.mit.edu	37	11	63487482	63487482	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63487482C>T	uc001nxq.2	+	3	1695	c.1508C>T	c.(1507-1509)ACA>ATA	p.T503I	RTN3_uc001nxo.2_Intron|RTN3_uc001nxm.2_Intron|RTN3_uc001nxn.2_Missense_Mutation_p.T484I|RTN3_uc001nxp.2_Intron|RTN3_uc009yov.2_Missense_Mutation_p.T391I|RTN3_uc010rmt.1_Intron|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	503					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1																		---	---	---	---
RCOR2	283248	broad.mit.edu	37	11	63681926	63681926	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63681926C>T	uc001nyc.2	-	6	956	c.568G>A	c.(568-570)GCC>ACC	p.A190T		NM_173587	NP_775858	Q8IZ40	RCOR2_HUMAN	REST corepressor 2	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)|skin(1)	2																		---	---	---	---
FLRT1	23769	broad.mit.edu	37	11	63884888	63884888	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63884888G>A	uc001nyi.1	+	2	1490	c.1149G>A	c.(1147-1149)CCG>CCA	p.P383P	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	355	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0																		---	---	---	---
STIP1	10963	broad.mit.edu	37	11	63965054	63965054	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63965054C>T	uc001nyk.1	+	7	1036	c.889C>T	c.(889-891)CGA>TGA	p.R297*	STIP1_uc010rnb.1_Nonsense_Mutation_p.R273*	NM_006819	NP_006810	P31948	STIP1_HUMAN	stress-induced-phosphoprotein 1	297					axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3																		---	---	---	---
CCDC88B	283234	broad.mit.edu	37	11	64120560	64120560	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64120560C>T	uc001nzy.2	+	21	3579	c.3535C>T	c.(3535-3537)CGG>TGG	p.R1179W	CCDC88B_uc009ypo.1_Missense_Mutation_p.R1176W|CCDC88B_uc001oaa.2_Missense_Mutation_p.R331W|CCDC88B_uc001oab.1_Missense_Mutation_p.R10W|CCDC88B_uc001oac.2_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1179	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64398015	64398015	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64398015C>T	uc001oap.2	-	4	989	c.478G>A	c.(478-480)GTG>ATG	p.V160M	NRXN2_uc001oar.2_Missense_Mutation_p.V1206M|NRXN2_uc001oas.2_Missense_Mutation_p.V1166M|NRXN2_uc001oaq.2_Missense_Mutation_p.V873M	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	160	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64419563	64419563	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64419563C>T	uc001oar.2	-	14	2919	c.2480G>A	c.(2479-2481)AGG>AAG	p.R827K	NRXN2_uc001oas.2_Missense_Mutation_p.R787K|NRXN2_uc001oaq.2_Missense_Mutation_p.R494K	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	183	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
ATG2A	23130	broad.mit.edu	37	11	64677290	64677290	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64677290T>C	uc001obx.2	-	14	2085	c.1970A>G	c.(1969-1971)GAC>GGC	p.D657G		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	657							protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GPHA2	170589	broad.mit.edu	37	11	64702546	64702546	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64702546G>A	uc001oca.2	-	3	260	c.205C>T	c.(205-207)CGG>TGG	p.R69W		NM_130769	NP_570125	Q96T91	GPHA2_HUMAN	glycoprotein hormone alpha 2 precursor	69						extracellular region	hormone activity				0																		---	---	---	---
SAC3D1	29901	broad.mit.edu	37	11	64811817	64811817	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64811817T>C	uc001ocm.2	+	2	1084	c.695T>C	c.(694-696)TTC>TCC	p.F232S	SAC3D1_uc010rnv.1_Missense_Mutation_p.F219S	NM_013299	NP_037431			SAC3 domain containing 1												0																		---	---	---	---
ZFPL1	7542	broad.mit.edu	37	11	64855573	64855573	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64855573T>C	uc001ocq.1	+	8	1085	c.920T>C	c.(919-921)GTG>GCG	p.V307A		NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	307	Lumenal (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
C11orf2	738	broad.mit.edu	37	11	64876190	64876190	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64876190C>T	uc001ocr.1	+	5	1287	c.1247C>T	c.(1246-1248)GCG>GTG	p.A416V	C11orf2_uc001ocs.1_Missense_Mutation_p.A292V	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	416					lipid transport|protein transport	Golgi apparatus|integral to membrane					0																		---	---	---	---
TM7SF2	7108	broad.mit.edu	37	11	64880808	64880808	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64880808G>A	uc001oct.2	+	4	568	c.421G>A	c.(421-423)GCT>ACT	p.A141T	TM7SF2_uc010rny.1_Missense_Mutation_p.A25T|TM7SF2_uc001ocu.2_Missense_Mutation_p.A141T|TM7SF2_uc001ocv.2_Missense_Mutation_p.A162T	NM_003273	NP_003264	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	141	Helical; (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			ovary(1)	1																OREG0021072	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SPDYC	387778	broad.mit.edu	37	11	64940375	64940375	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64940375G>A	uc010rnz.1	+	6	737	c.737G>A	c.(736-738)CGC>CAC	p.R246H		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	246					cell cycle	nucleus	protein kinase binding				0																		---	---	---	---
TIGD3	220359	broad.mit.edu	37	11	65123616	65123616	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65123616A>G	uc001odo.3	+	2	500	c.337A>G	c.(337-339)ATG>GTG	p.M113V		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	113	H-T-H motif (By similarity).|HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0																		---	---	---	---
SLC25A45	283130	broad.mit.edu	37	11	65143909	65143909	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65143909C>T	uc001odp.1	-	6	1258	c.836G>A	c.(835-837)AGC>AAC	p.S279N	SLC25A45_uc009yqi.1_Missense_Mutation_p.S217N|SLC25A45_uc001odq.1_Missense_Mutation_p.S255N|SLC25A45_uc001odr.1_Missense_Mutation_p.S279N|SLC25A45_uc001ods.1_Missense_Mutation_p.S237N|SLC25A45_uc001odt.1_Missense_Mutation_p.S237N	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	279	Helical; Name=6; (Potential).|Solcar 3.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65268497	65268497	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65268497A>G	uc010roh.1	+	1		c.3265A>G			uc001ody.2_RNA|MALAT1_uc001odz.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65269794	65269794	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65269794A>G	uc010roh.1	+	1		c.4562A>G			uc001ody.2_RNA|MALAT1_uc001odz.2_RNA	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
MALAT1	378938	broad.mit.edu	37	11	65271405	65271405	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65271405A>G	uc010roh.1	+	1		c.6173A>G			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0																		---	---	---	---
EHBP1L1	254102	broad.mit.edu	37	11	65351025	65351025	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65351025T>C	uc001oeo.3	+	9	3147	c.2882T>C	c.(2881-2883)GTT>GCT	p.V961A	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	961										central_nervous_system(1)	1																		---	---	---	---
PCNXL3	399909	broad.mit.edu	37	11	65396413	65396413	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65396413A>G	uc001oey.2	+	24	3935	c.3935A>G	c.(3934-3936)GAC>GGC	p.D1312G	PCNXL3_uc001oez.2_Missense_Mutation_p.D199G	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1312						integral to membrane					0																		---	---	---	---
OVOL1	5017	broad.mit.edu	37	11	65562117	65562117	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65562117G>A	uc001ofp.2	+	3	743	c.427G>A	c.(427-429)GTC>ATC	p.V143I	OVOL1_uc001ofq.2_Missense_Mutation_p.V81I	NM_004561	NP_004552	O14753	OVOL1_HUMAN	OVO-like 1 binding protein	143					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.17)														---	---	---	---
EFEMP2	30008	broad.mit.edu	37	11	65635808	65635808	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65635808T>C	uc001ofy.3	-	9	1126	c.932A>G	c.(931-933)GAC>GGC	p.D311G	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.D311G	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	311	EGF-like 6; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)														---	---	---	---
CTSW	1521	broad.mit.edu	37	11	65650552	65650552	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65650552A>G	uc001ogc.1	+	8	800	c.758A>G	c.(757-759)TAC>TGC	p.Y253C	CTSW_uc001ogb.1_Missense_Mutation_p.Y253C	NM_001335	NP_001326	P56202	CATW_HUMAN	cathepsin W preproprotein	253					immune response|proteolysis		cysteine-type endopeptidase activity			central_nervous_system(1)	1				READ - Rectum adenocarcinoma(159;0.168)														---	---	---	---
SART1	9092	broad.mit.edu	37	11	65734962	65734962	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65734962G>A	uc001ogl.2	+	11	1426	c.1334G>A	c.(1333-1335)CGC>CAC	p.R445H		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	445					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1																		---	---	---	---
SART1	9092	broad.mit.edu	37	11	65745360	65745360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65745360C>T	uc001ogl.2	+	17	2254	c.2162C>T	c.(2161-2163)ACA>ATA	p.T721I		NM_005146	NP_005137	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T	721					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				ovary(1)	1																		---	---	---	---
GAL3ST3	89792	broad.mit.edu	37	11	65810615	65810615	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65810615T>C	uc001ogv.2	-	2	819	c.659A>G	c.(658-660)GAC>GGC	p.D220G	GAL3ST3_uc001ogw.2_Missense_Mutation_p.D220G	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	220	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1																		---	---	---	---
GAL3ST3	89792	broad.mit.edu	37	11	65810616	65810616	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65810616C>T	uc001ogv.2	-	2	818	c.658G>A	c.(658-660)GAC>AAC	p.D220N	GAL3ST3_uc001ogw.2_Missense_Mutation_p.D220N	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	220	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1																		---	---	---	---
GAL3ST3	89792	broad.mit.edu	37	11	65811111	65811111	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65811111G>A	uc001ogv.2	-	2	323	c.163C>T	c.(163-165)CGG>TGG	p.R55W	GAL3ST3_uc001ogw.2_Missense_Mutation_p.R55W	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	55	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1																		---	---	---	---
SF3B2	10992	broad.mit.edu	37	11	65829239	65829239	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65829239T>C	uc001ogy.1	+	15	1902	c.1862T>C	c.(1861-1863)GTA>GCA	p.V621A		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	621					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3																		---	---	---	---
SF3B2	10992	broad.mit.edu	37	11	65830509	65830509	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65830509C>T	uc001ogy.1	+	17	2047	c.2007C>T	c.(2005-2007)GGC>GGT	p.G669G		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	669					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3																		---	---	---	---
CD248	57124	broad.mit.edu	37	11	66083132	66083132	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66083132G>A	uc001ohm.1	-	1	1384	c.1367C>T	c.(1366-1368)ACG>ATG	p.T456M		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	456	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)													---	---	---	---
CTSF	8722	broad.mit.edu	37	11	66335072	66335072	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66335072C>T	uc001oip.2	-	3	464	c.374G>A	c.(373-375)GGC>GAC	p.G125D		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	125					proteolysis	lysosome	cysteine-type endopeptidase activity				0																		---	---	---	---
CCDC87	55231	broad.mit.edu	37	11	66358970	66358970	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66358970T>C	uc001oiq.3	-	1	1585	c.1517A>G	c.(1516-1518)CAC>CGC	p.H506R	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	506										ovary(1)|skin(1)	2																		---	---	---	---
RBM14	10432	broad.mit.edu	37	11	66392441	66392441	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66392441A>G	uc001oit.2	+	2	1233	c.1094A>G	c.(1093-1095)TAC>TGC	p.Y365C	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	365	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
RBM14	10432	broad.mit.edu	37	11	66393007	66393007	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66393007C>T	uc001oit.2	+	2	1799	c.1660C>T	c.(1660-1662)CCG>TCG	p.P554S	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	554	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
RBM14	10432	broad.mit.edu	37	11	66393926	66393926	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66393926G>A	uc001oit.2	+						RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319			RNA binding motif protein 14						DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
RBM4	5936	broad.mit.edu	37	11	66411167	66411167	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66411167C>T	uc009yrj.2	+	3	1147	c.659C>T	c.(658-660)GCC>GTC	p.A220V	RBM4_uc009yrk.2_Missense_Mutation_p.A195V|RBM4_uc001oiw.1_Missense_Mutation_p.A220V|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Missense_Mutation_p.A220V|RBM4_uc001oiz.1_Missense_Mutation_p.A220V	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	220	Interaction with TNPO3.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)														---	---	---	---
SPTBN2	6712	broad.mit.edu	37	11	66468627	66468627	+	Silent	SNP	G	A	A	rs139352096		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66468627G>A	uc001ojd.2	-	16	3015	c.2943C>T	c.(2941-2943)ATC>ATT	p.I981I		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	981	Spectrin 7.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
CARNS1	57571	broad.mit.edu	37	11	67191326	67191326	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67191326C>T	uc009yrp.2	+	9	2190	c.1738C>T	c.(1738-1740)CGA>TGA	p.R580*	PPP1CA_uc001okx.1_5'Flank|CARNS1_uc001olc.3_Nonsense_Mutation_p.R719*	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	580	ATP-grasp.|ATP (By similarity).				carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0																		---	---	---	---
CABP4	57010	broad.mit.edu	37	11	67223796	67223796	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67223796G>A	uc001olo.2	+	3	501	c.424G>A	c.(424-426)GAC>AAC	p.D142N	CABP4_uc001oln.2_Missense_Mutation_p.D37N	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	142	1 (Potential).|EF-hand 1.				visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)															---	---	---	---
PITPNM1	9600	broad.mit.edu	37	11	67267701	67267701	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67267701C>A	uc001olx.2	-	5	1021	c.832G>T	c.(832-834)GCC>TCC	p.A278S	PITPNM1_uc001olw.2_5'Flank|PITPNM1_uc001oly.2_Missense_Mutation_p.A278S|PITPNM1_uc001olz.2_Missense_Mutation_p.A278S	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	278					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3																		---	---	---	---
TBX10	347853	broad.mit.edu	37	11	67399796	67399796	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67399796C>T	uc001omp.2	-	7	949	c.861G>A	c.(859-861)AGG>AGA	p.R287R	NUDT8_uc001omn.2_5'Flank|NUDT8_uc001omo.1_5'Flank	NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	287					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
ACY3	91703	broad.mit.edu	37	11	67410319	67410319	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67410319T>C	uc001omq.2	-	8	1007	c.836A>G	c.(835-837)TAC>TGC	p.Y279C		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	279					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)													---	---	---	---
C11orf24	53838	broad.mit.edu	37	11	68029961	68029961	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68029961C>T	uc001onr.3	-	4	944	c.502G>A	c.(502-504)GCG>ACG	p.A168T	C11orf24_uc001ons.2_Missense_Mutation_p.A168T	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	168	Extracellular (Potential).					integral to membrane					0																		---	---	---	---
LRP5	4041	broad.mit.edu	37	11	68192577	68192577	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68192577T>C	uc001ont.2	+	15	3319	c.3244T>C	c.(3244-3246)TAC>CAC	p.Y1082H	LRP5_uc009ysg.2_Missense_Mutation_p.Y492H	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1082	LDL-receptor class B 18.|Beta-propeller 4.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7																		---	---	---	---
MTL5	9633	broad.mit.edu	37	11	68475936	68475936	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68475936A>G	uc001ooc.2	-	10	1507	c.1367T>C	c.(1366-1368)GTG>GCG	p.V456A		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	456					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)															---	---	---	---
IGHMBP2	3508	broad.mit.edu	37	11	68678967	68678967	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68678967G>A	uc001ook.1	+	5	709	c.607G>A	c.(607-609)GCG>ACG	p.A203T	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	203					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
IGHMBP2	3508	broad.mit.edu	37	11	68705747	68705747	+	Silent	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68705747A>C	uc001ook.1	+	14	2811	c.2709A>C	c.(2707-2709)ACA>ACC	p.T903T	IGHMBP2_uc001ool.1_Silent_p.T527T	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	903	AN1-type.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
TPCN2	219931	broad.mit.edu	37	11	68846360	68846360	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68846360A>T	uc001oos.2	+	16	1527	c.1411A>T	c.(1411-1413)ATT>TTT	p.I471F	TPCN2_uc001oor.2_Missense_Mutation_p.I386F|TPCN2_uc010rqg.1_Missense_Mutation_p.I471F|TPCN2_uc001oot.2_RNA	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	471	Helical; Name=S2 of repeat II; (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
ORAOV1	220064	broad.mit.edu	37	11	69482723	69482723	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69482723A>G	uc001opc.2	-	4	443	c.285T>C	c.(283-285)GAT>GAC	p.D95D	ORAOV1_uc010rqi.1_Silent_p.D95D|ORAOV1_uc009ysm.2_RNA|ORAOV1_uc001opd.2_Silent_p.D36D	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	95											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)															---	---	---	---
ORAOV1	220064	broad.mit.edu	37	11	69486577	69486577	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69486577T>C	uc001opc.2	-	3	325	c.167A>G	c.(166-168)TAC>TGC	p.Y56C	ORAOV1_uc010rqi.1_Missense_Mutation_p.Y56C|ORAOV1_uc009ysm.2_Intron|ORAOV1_uc001opd.2_Intron|ORAOV1_uc001ope.1_Missense_Mutation_p.Y56C	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	56											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)															---	---	---	---
PPFIA1	8500	broad.mit.edu	37	11	70172691	70172691	+	Intron	SNP	T	C	C	rs58447267		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70172691T>C	uc001opo.2	+						PPFIA1_uc001opn.1_Intron|PPFIA1_uc001opp.2_Intron|PPFIA1_uc001opq.1_Intron	NM_003626	NP_003617			PTPRF interacting protein alpha 1 isoform b						cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)															---	---	---	---
CTTN	2017	broad.mit.edu	37	11	70265913	70265913	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70265913C>A	uc001opv.3	+	9	836	c.630C>A	c.(628-630)GCC>GCA	p.A210A	CTTN_uc001opu.2_Silent_p.A210A|CTTN_uc001opw.3_Silent_p.A210A|CTTN_uc010rqm.1_5'Flank|CTTN_uc001opx.2_5'Flank	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	210	Cortactin 4.					cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)														---	---	---	---
SHANK2	22941	broad.mit.edu	37	11	70333642	70333642	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70333642G>A	uc001oqc.2	-	21	2834	c.2756C>T	c.(2755-2757)ACG>ATG	p.T919M	SHANK2_uc010rqn.1_Missense_Mutation_p.T331M|SHANK2_uc001opz.2_Missense_Mutation_p.T324M|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	540					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)															---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71726677	71726677	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71726677A>G	uc001orl.1	-	15	2044	c.1872T>C	c.(1870-1872)CTT>CTC	p.L624L	NUMA1_uc009ysw.1_Silent_p.L187L|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Silent_p.L624L|NUMA1_uc001orn.2_Silent_p.L187L|NUMA1_uc009ysx.1_Silent_p.L624L|NUMA1_uc001oro.1_Silent_p.L624L	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	624	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
INPPL1	3636	broad.mit.edu	37	11	71943988	71943988	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71943988C>T	uc001osf.2	+	16	2068	c.1921C>T	c.(1921-1923)CGG>TGG	p.R641W	INPPL1_uc001osg.2_Missense_Mutation_p.R399W	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	641					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4																		---	---	---	---
PDE2A	5138	broad.mit.edu	37	11	72288519	72288519	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72288519G>A	uc010rrc.1	-	31	2978	c.2735C>T	c.(2734-2736)TCG>TTG	p.S912L	PDE2A_uc001oso.2_Missense_Mutation_p.S891L|PDE2A_uc010rra.1_Missense_Mutation_p.S905L|PDE2A_uc001osn.2_Missense_Mutation_p.S656L|PDE2A_uc010rrb.1_Missense_Mutation_p.S903L|PDE2A_uc010rrd.1_Missense_Mutation_p.S797L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	912					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)													---	---	---	---
ARAP1	116985	broad.mit.edu	37	11	72408664	72408664	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72408664A>G	uc001osu.2	-	20	2957	c.2768T>C	c.(2767-2769)CTG>CCG	p.L923P	ARAP1_uc001osv.2_Missense_Mutation_p.L923P|ARAP1_uc001osr.2_Missense_Mutation_p.L683P|ARAP1_uc001oss.2_Missense_Mutation_p.L678P|ARAP1_uc009yth.2_Missense_Mutation_p.L617P|ARAP1_uc010rre.1_Missense_Mutation_p.L678P	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	923					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1																		---	---	---	---
PAAF1	80227	broad.mit.edu	37	11	73638354	73638354	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73638354T>C	uc001ouk.1	+	12	1160	c.1126T>C	c.(1126-1128)TAC>CAC	p.Y376H	PAAF1_uc001oul.1_Missense_Mutation_p.Y359H|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.Y359H|PAAF1_uc001oun.1_RNA	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	376	WD 5.				interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)																	---	---	---	---
UCP3	7352	broad.mit.edu	37	11	73716934	73716934	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73716934C>T	uc001our.2	-	4	737	c.382G>A	c.(382-384)GCC>ACC	p.A128T	UCP3_uc001ous.2_Missense_Mutation_p.A128T	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	128	Solcar 2.|Helical; Name=3; (Potential).				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)																	---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73824826	73824826	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73824826T>C	uc001ouu.2	-	11	2069	c.1842A>G	c.(1840-1842)GGA>GGG	p.G614G	C2CD3_uc001ouv.2_Silent_p.G614G	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	614						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
XRRA1	143570	broad.mit.edu	37	11	74554950	74554950	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74554950C>A	uc009yub.2	-	18	2406	c.2074G>T	c.(2074-2076)GAC>TAC	p.D692Y	XRRA1_uc001ovm.2_Intron|XRRA1_uc001ovn.2_Missense_Mutation_p.D315Y|XRRA1_uc001ovo.2_Missense_Mutation_p.D300Y|XRRA1_uc001ovq.3_Intron|XRRA1_uc001ovp.3_Missense_Mutation_p.D417Y|XRRA1_uc001ovr.2_Missense_Mutation_p.D315Y|XRRA1_uc001ovs.1_3'UTR	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	692					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1																		---	---	---	---
SLCO2B1	11309	broad.mit.edu	37	11	74911354	74911354	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74911354T>C	uc001owb.2	+	11	2072	c.1685T>C	c.(1684-1686)GTG>GCG	p.V562A	SLCO2B1_uc010rrq.1_Missense_Mutation_p.V307A|SLCO2B1_uc010rrr.1_Missense_Mutation_p.V418A|SLCO2B1_uc010rrs.1_Missense_Mutation_p.V446A|SLCO2B1_uc001owc.2_Missense_Mutation_p.V335A|SLCO2B1_uc001owd.2_Missense_Mutation_p.V540A	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	562	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)													---	---	---	---
ACER3	55331	broad.mit.edu	37	11	76730809	76730809	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76730809C>T	uc009yum.1	+	10	843	c.739C>T	c.(739-741)CCA>TCA	p.P247S	ACER3_uc001oxu.2_RNA|ACER3_uc009yun.1_Missense_Mutation_p.P205S|ACER3_uc009yuo.1_Missense_Mutation_p.P152S|ACER3_uc010rsh.1_Missense_Mutation_p.P210S|ACER3_uc010rsi.1_Missense_Mutation_p.P152S|ACER3_uc010rsj.1_Missense_Mutation_p.P152S	NM_018367	NP_060837	Q9NUN7	ACER3_HUMAN	phytoceramidase, alkaline	247					ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0																		---	---	---	---
KCTD21	283219	broad.mit.edu	37	11	77884849	77884849	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77884849T>C	uc001ozb.2	-	2	827	c.752A>G	c.(751-753)AAT>AGT	p.N251S		NM_001029859	NP_001025030	Q4G0X4	KCD21_HUMAN	potassium channel tetramerisation domain	251						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)															---	---	---	---
USP35	57558	broad.mit.edu	37	11	77907363	77907363	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77907363C>T	uc009yva.1	+	2	318	c.72C>T	c.(70-72)CGC>CGT	p.R24R	USP35_uc001oze.2_Intron|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_5'UTR|USP35_uc001ozf.2_5'Flank	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	24					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)															---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78369544	78369544	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78369544T>C	uc001ozl.3	-	34	8332	c.7869A>G	c.(7867-7869)GGA>GGG	p.G2623G	ODZ4_uc001ozk.3_Silent_p.G848G|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2623	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78383286	78383286	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78383286C>T	uc001ozl.3	-	31	6048	c.5585G>A	c.(5584-5586)CGG>CAG	p.R1862Q	ODZ4_uc001ozk.3_Missense_Mutation_p.R87Q|ODZ4_uc009yvb.1_Missense_Mutation_p.R446Q	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1862	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
DLG2	1740	broad.mit.edu	37	11	83641391	83641391	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:83641391T>C	uc001paj.2	-	10	1464	c.1161A>G	c.(1159-1161)CTA>CTG	p.L387L	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Silent_p.L354L|DLG2_uc010rsz.1_Silent_p.L387L|DLG2_uc010rta.1_Silent_p.L387L|DLG2_uc001pak.2_Silent_p.L492L|DLG2_uc010rtb.1_Silent_p.L354L|DLG2_uc001pal.1_Silent_p.L387L|DLG2_uc001pam.1_Silent_p.L426L	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	387						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)																---	---	---	---
DLG2	1740	broad.mit.edu	37	11	83810087	83810087	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:83810087T>A	uc001paj.2	-	5	616	c.313A>T	c.(313-315)AAT>TAT	p.N105Y	DLG2_uc001pai.2_Missense_Mutation_p.N54Y|DLG2_uc010rsy.1_Missense_Mutation_p.N72Y|DLG2_uc010rsz.1_Missense_Mutation_p.N105Y|DLG2_uc010rta.1_Missense_Mutation_p.N105Y|DLG2_uc001pak.2_Missense_Mutation_p.N210Y|DLG2_uc010rtb.1_Missense_Mutation_p.N72Y|DLG2_uc001pal.1_Missense_Mutation_p.N105Y|DLG2_uc001pam.1_Missense_Mutation_p.N144Y	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	105	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)																---	---	---	---
PRSS23	11098	broad.mit.edu	37	11	86519334	86519334	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86519334A>G	uc001pcb.2	+	2	865	c.649A>G	c.(649-651)ATG>GTG	p.M217V	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.M185V	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	217					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
TMEM135	65084	broad.mit.edu	37	11	87029214	87029214	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:87029214T>C	uc001pch.2	+	13	1136	c.1113T>C	c.(1111-1113)GTT>GTC	p.V371V	TMEM135_uc010rtt.1_Silent_p.V232V|TMEM135_uc001pci.2_Silent_p.V349V	NM_022918	NP_075069	Q86UB9	TM135_HUMAN	transmembrane protein 135	371						integral to membrane					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
GRM5	2915	broad.mit.edu	37	11	88337911	88337911	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:88337911C>T	uc001pcq.2	-	4	1569	c.1369G>A	c.(1369-1371)GAT>AAT	p.D457N	GRM5_uc009yvm.2_Missense_Mutation_p.D457N	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	457	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)													---	---	---	---
NOX4	50507	broad.mit.edu	37	11	89224368	89224368	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89224368T>C	uc001pct.2	-	1	286	c.47A>G	c.(46-48)CAC>CGC	p.H16R	NOX4_uc009yvr.2_5'Flank|NOX4_uc001pcu.2_5'UTR|NOX4_uc001pcw.2_Missense_Mutation_p.H16R|NOX4_uc001pcx.2_Missense_Mutation_p.H16R|NOX4_uc001pcv.2_Missense_Mutation_p.H16R|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_5'UTR|NOX4_uc009yvp.2_Missense_Mutation_p.H16R|NOX4_uc010rtv.1_Intron|NOX4_uc009yvq.2_Intron|NOX4_uc009yvs.1_RNA|NOX4_uc001pcy.2_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	16	Cytoplasmic (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)																---	---	---	---
NAALAD2	10003	broad.mit.edu	37	11	89880585	89880585	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89880585A>G	uc001pdf.3	+	3	391	c.282A>G	c.(280-282)GGA>GGG	p.G94G	NAALAD2_uc009yvx.2_Silent_p.G94G|NAALAD2_uc009yvy.2_Silent_p.G94G|NAALAD2_uc001pdd.2_Silent_p.G94G|NAALAD2_uc001pde.2_Silent_p.G94G	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	94	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
CHORDC1	26973	broad.mit.edu	37	11	89947184	89947184	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89947184A>G	uc001pdg.2	-	4	739	c.329_splice	c.e4+1	p.S110_splice	CHORDC1_uc009yvz.2_Splice_Site_p.S91_splice	NM_012124	NP_036256			cysteine and histidine-rich domain-containing						chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92495039	92495039	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92495039T>C	uc001pdj.3	+	4	3704	c.3687T>C	c.(3685-3687)GGT>GGC	p.G1229G		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1229	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92531033	92531033	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92531033G>A	uc001pdj.3	+	9	4871	c.4854G>A	c.(4852-4854)CCG>CCA	p.P1618P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1618	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92532943	92532943	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92532943A>G	uc001pdj.3	+	9	6781	c.6764A>G	c.(6763-6765)AAG>AGG	p.K2255R		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2255	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92538325	92538325	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92538325A>G	uc001pdj.3	+	10	8920	c.8903A>G	c.(8902-8904)AAC>AGC	p.N2968S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2968	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
SLC36A4	120103	broad.mit.edu	37	11	92901114	92901114	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92901114A>G	uc001pdn.2	-	7	861	c.764T>C	c.(763-765)GTC>GCC	p.V255A	SLC36A4_uc001pdm.2_Missense_Mutation_p.V120A	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	255					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)																---	---	---	---
ENDOD1	23052	broad.mit.edu	37	11	94862578	94862578	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94862578C>T	uc001pfh.2	+	2	1413	c.1338C>T	c.(1336-1338)GGC>GGT	p.G446G		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	446						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)																---	---	---	---
SESN3	143686	broad.mit.edu	37	11	94911072	94911072	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94911072T>C	uc001pfk.1	-	8	1280	c.1058A>G	c.(1057-1059)GAC>GGC	p.D353G	SESN3_uc010rug.1_Missense_Mutation_p.D214G	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	353					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)														---	---	---	---
CEP57	9702	broad.mit.edu	37	11	95562484	95562484	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95562484T>A	uc001pfp.1	+	10	1482	c.1261T>A	c.(1261-1263)TAC>AAC	p.Y421N	CEP57_uc010ruh.1_Missense_Mutation_p.Y412N|CEP57_uc010rui.1_Missense_Mutation_p.Y395N|CEP57_uc009ywn.1_Missense_Mutation_p.Y269N|CEP57_uc001pfq.1_Missense_Mutation_p.Y395N|CEP57_uc001pfr.1_Missense_Mutation_p.Y269N	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	421	Mediates interaction with microtubules (By similarity).|Potential.				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)												Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
MAML2	84441	broad.mit.edu	37	11	95712489	95712489	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95712489T>C	uc001pfw.1	-	5	4379	c.3094A>G	c.(3094-3096)ATG>GTG	p.M1032V		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	1032					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)						T	MECT1|CRTC3	salivary gland mucoepidermoid								---	---	---	---
MAML2	84441	broad.mit.edu	37	11	95826382	95826382	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95826382C>G	uc001pfw.1	-	2	2098	c.813G>C	c.(811-813)GAG>GAC	p.E271D		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	271					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)						T	MECT1|CRTC3	salivary gland mucoepidermoid								---	---	---	---
CNTN5	53942	broad.mit.edu	37	11	100221600	100221600	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:100221600A>G	uc001pga.2	+	24	3537	c.3198A>G	c.(3196-3198)TCA>TCG	p.S1066S	CNTN5_uc001pgb.2_Silent_p.S992S|CNTN5_uc010ruk.1_Silent_p.S337S	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	1066					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)														---	---	---	---
KIAA1377	57562	broad.mit.edu	37	11	101815143	101815143	+	Splice_Site	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:101815143T>A	uc001pgm.2	+	3	664	c.394_splice	c.e3+2	p.V132_splice	KIAA1377_uc001pgn.2_Splice_Site_p.V88_splice|KIAA1377_uc009yxa.1_Splice_Site	NM_020802	NP_065853			hypothetical protein LOC57562								protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)														---	---	---	---
MMP10	4319	broad.mit.edu	37	11	102650475	102650475	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102650475T>C	uc001phg.1	-	2	129	c.107A>G	c.(106-108)CAA>CGA	p.Q36R		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	36					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)														---	---	---	---
DCUN1D5	84259	broad.mit.edu	37	11	102953982	102953982	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:102953982T>C	uc001phm.2	-						DCUN1D5_uc010ruw.1_Intron	NM_032299	NP_115675			DCN1, defective in cullin neddylation 1, domain												0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103068666	103068666	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103068666T>C	uc001pho.2	+	48	7857	c.7713T>C	c.(7711-7713)AGT>AGC	p.S2571S	DYNC2H1_uc001phn.1_Silent_p.S2571S|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2571					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DDI1	414301	broad.mit.edu	37	11	103907841	103907841	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103907841T>C	uc001phr.2	+	1	534	c.291T>C	c.(289-291)AGT>AGC	p.S97S	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	97					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)														---	---	---	---
CARD16	114769	broad.mit.edu	37	11	104915212	104915212	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:104915212C>T	uc001pip.1	-	2	208	c.181G>A	c.(181-183)GTT>ATT	p.V61I	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Missense_Mutation_p.V61I	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	61	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1																		---	---	---	---
CARD16	114769	broad.mit.edu	37	11	104915354	104915354	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:104915354A>G	uc001pip.1	-	2	66	c.39T>C	c.(37-39)TTT>TTC	p.F13F	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Silent_p.F13F	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE	13	CARD.				regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1																		---	---	---	---
GRIA4	2893	broad.mit.edu	37	11	105758275	105758275	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105758275T>C	uc001pix.2	+	6	1149	c.703T>C	c.(703-705)TAC>CAC	p.Y235H	GRIA4_uc001piu.1_Missense_Mutation_p.Y235H|GRIA4_uc001piw.2_Missense_Mutation_p.Y235H|GRIA4_uc009yxk.1_Missense_Mutation_p.Y235H	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	235	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)													---	---	---	---
GRIA4	2893	broad.mit.edu	37	11	105776013	105776013	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105776013A>G	uc001pix.2	+	9	1590	c.1144A>G	c.(1144-1146)ACA>GCA	p.T382A	GRIA4_uc001piu.1_Missense_Mutation_p.T382A|GRIA4_uc001piw.2_Missense_Mutation_p.T382A|GRIA4_uc009yxk.1_Missense_Mutation_p.T382A	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	382	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)													---	---	---	---
GUCY1A2	2977	broad.mit.edu	37	11	106810451	106810451	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:106810451G>A	uc001pjg.1	-	4	1331	c.941C>T	c.(940-942)GCG>GTG	p.A314V	GUCY1A2_uc010rvo.1_Missense_Mutation_p.A314V|GUCY1A2_uc009yxn.1_Missense_Mutation_p.A314V	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	314					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)														---	---	---	---
CWF19L2	143884	broad.mit.edu	37	11	107299652	107299652	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107299652A>G	uc010rvp.1	-	8	1336	c.1306T>C	c.(1306-1308)TCG>CCG	p.S436P	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	436							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)														---	---	---	---
ELMOD1	55531	broad.mit.edu	37	11	107535915	107535915	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107535915A>G	uc010rvs.1	+	12	1401	c.997A>G	c.(997-999)AAC>GAC	p.N333D	ELMOD1_uc001pjm.2_Missense_Mutation_p.N325D|ELMOD1_uc010rvt.1_Missense_Mutation_p.N327D	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	333					phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)														---	---	---	---
CUL5	8065	broad.mit.edu	37	11	107965548	107965548	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107965548T>C	uc001pjv.2	+	15	2244	c.1577T>C	c.(1576-1578)GTT>GCT	p.V526A	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	526					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)														---	---	---	---
ACAT1	38	broad.mit.edu	37	11	108017014	108017014	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108017014T>C	uc001pjy.2	+	11	1167	c.1091T>C	c.(1090-1092)ATT>ACT	p.I364T		NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	364					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)													---	---	---	---
ATM	472	broad.mit.edu	37	11	108159816	108159816	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108159816C>T	uc001pkb.1	+	28	4607	c.4222C>T	c.(4222-4224)CTT>TTT	p.L1408F	ATM_uc009yxr.1_Missense_Mutation_p.L1408F|ATM_uc001pkd.3_Missense_Mutation_p.L60F|ATM_uc001pke.1_Missense_Mutation_p.L60F|ATM_uc010rvw.1_Missense_Mutation_p.L60F|ATM_uc001pkf.2_Missense_Mutation_p.L60F	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1408					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
ATM	472	broad.mit.edu	37	11	108202676	108202676	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108202676A>G	uc001pkb.1	+	52	8085	c.7700A>G	c.(7699-7701)AAC>AGC	p.N2567S	ATM_uc009yxr.1_Missense_Mutation_p.N2567S|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.N1219S|ATM_uc001pkg.1_Missense_Mutation_p.N924S	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2567					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
ATM	472	broad.mit.edu	37	11	108236086	108236086	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108236086C>T	uc001pkb.1	+	63	9407	c.9022C>T	c.(9022-9024)CGT>TGT	p.R3008C	ATM_uc009yxr.1_Missense_Mutation_p.R3008C|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.R1660C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3008			R -> C (in AT, T-prolymphocytic leukemia and mantle cell lymphoma).|R -> H (in B-cell chronic lymphocytic leukemia).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R3008C(4)|p.R3008H(4)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
EXPH5	23086	broad.mit.edu	37	11	108382343	108382343	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108382343T>C	uc001pkk.2	-	6	4002	c.3891A>G	c.(3889-3891)AAA>AAG	p.K1297K	EXPH5_uc010rvy.1_Silent_p.K1109K|EXPH5_uc010rvz.1_Silent_p.K1141K|EXPH5_uc010rwa.1_Silent_p.K1221K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1297					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)														---	---	---	---
EXPH5	23086	broad.mit.edu	37	11	108389088	108389088	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108389088A>G	uc001pkk.2	-	5	616	c.505T>C	c.(505-507)TAC>CAC	p.Y169H	EXPH5_uc010rvy.1_5'UTR|EXPH5_uc010rvz.1_Missense_Mutation_p.Y13H|EXPH5_uc010rwa.1_Missense_Mutation_p.Y93H	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	169					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)														---	---	---	---
PPP2R1B	5519	broad.mit.edu	37	11	111612842	111612842	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111612842A>G	uc001plx.1	-	14	1808	c.1724T>C	c.(1723-1725)GTA>GCA	p.V575A	PPP2R1B_uc001plw.1_Missense_Mutation_p.V575A|PPP2R1B_uc010rwi.1_Missense_Mutation_p.V511A|PPP2R1B_uc010rwj.1_Missense_Mutation_p.V414A|PPP2R1B_uc010rwk.1_Missense_Mutation_p.V530A|PPP2R1B_uc010rwl.1_Missense_Mutation_p.V448A	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	575	HEAT 15.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)														---	---	---	---
PPP2R1B	5519	broad.mit.edu	37	11	111625257	111625257	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111625257G>C	uc001plx.1	-	8	1079	c.995C>G	c.(994-996)ACC>AGC	p.T332S	PPP2R1B_uc001plw.1_Missense_Mutation_p.T332S|PPP2R1B_uc010rwi.1_Missense_Mutation_p.T268S|PPP2R1B_uc010rwj.1_Missense_Mutation_p.T171S|PPP2R1B_uc010rwk.1_Missense_Mutation_p.T332S|PPP2R1B_uc010rwl.1_Missense_Mutation_p.T205S	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	332	HEAT 8.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)														---	---	---	---
C11orf57	55216	broad.mit.edu	37	11	111953431	111953431	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111953431G>A	uc001pmr.3	+	6	1295	c.614G>A	c.(613-615)CGC>CAC	p.R205H	C11orf57_uc001pmw.3_Missense_Mutation_p.R206H|C11orf57_uc001pmt.3_Missense_Mutation_p.R206H|C11orf57_uc001pmv.3_Missense_Mutation_p.R205H|C11orf57_uc001pms.3_Missense_Mutation_p.R177H	NM_001082970	NP_001076439	Q6ZUT1	CK057_HUMAN	hypothetical protein LOC55216 isoform b	205	Lys-rich.									breast(2)|ovary(1)	3		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)														---	---	---	---
USP28	57646	broad.mit.edu	37	11	113672318	113672318	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113672318A>G	uc001poh.2	-	24	2978	c.2945T>C	c.(2944-2946)CTG>CCG	p.L982P	USP28_uc001pog.2_Missense_Mutation_p.L658P|USP28_uc010rwy.1_Missense_Mutation_p.L825P|USP28_uc001poi.2_Missense_Mutation_p.L305P	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	982					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
USP28	57646	broad.mit.edu	37	11	113684655	113684655	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113684655A>G	uc001poh.2	-	15	1728	c.1695T>C	c.(1693-1695)AGT>AGC	p.S565S	USP28_uc001pog.2_Silent_p.S273S|USP28_uc010rwy.1_Silent_p.S440S|USP28_uc001poi.2_Intron|USP28_uc001poj.3_Silent_p.S565S	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	565					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
USP28	57646	broad.mit.edu	37	11	113694409	113694409	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113694409T>A	uc001poh.2	-	12	1234	c.1201A>T	c.(1201-1203)AGC>TGC	p.S401C	USP28_uc001pog.2_Missense_Mutation_p.S109C|USP28_uc010rwy.1_Missense_Mutation_p.S276C|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Missense_Mutation_p.S401C	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	401					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
APOA1	335	broad.mit.edu	37	11	116708093	116708093	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116708093G>A	uc001ppu.1	-	2	90	c.11C>T	c.(10-12)GCG>GTG	p.A4V	APOA1_uc001ppv.1_Missense_Mutation_p.A4V	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	4					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116717117	116717117	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116717117C>T	uc001ppy.2	-	23	3823	c.3787G>A	c.(3787-3789)GTG>ATG	p.V1263M	SIK3_uc001ppz.2_Missense_Mutation_p.V1102M|SIK3_uc001pqa.2_Missense_Mutation_p.V1203M|SIK3_uc001ppw.2_Missense_Mutation_p.V620M|SIK3_uc001ppx.2_Missense_Mutation_p.V641M	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	1263						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116719861	116719861	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116719861G>A	uc001ppy.2	-	21	3512	c.3476C>T	c.(3475-3477)ACG>ATG	p.T1159M	SIK3_uc001ppz.2_Missense_Mutation_p.T998M|SIK3_uc001pqa.2_Missense_Mutation_p.T1099M|SIK3_uc001ppw.2_Missense_Mutation_p.T516M|SIK3_uc001ppx.2_Missense_Mutation_p.T537M	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	1159						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
TAGLN	6876	broad.mit.edu	37	11	117073798	117073798	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117073798C>T	uc001pqm.2	+	2	190	c.69C>T	c.(67-69)GAC>GAT	p.D23D	uc001pqk.1_5'Flank|TAGLN_uc001pql.1_Intron|TAGLN_uc001pqn.2_Silent_p.D23D|TAGLN_uc001pqo.2_Silent_p.D23D|TAGLN_uc001pqp.2_Silent_p.D23D|uc001pqq.1_5'Flank	NM_003186	NP_003177	Q01995	TAGL_HUMAN	transgelin	23					muscle organ development	cytoplasm	actin binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|Epithelial(105;5.49e-05)|all cancers(92;0.000435)														---	---	---	---
PCSK7	9159	broad.mit.edu	37	11	117098958	117098958	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117098958T>C	uc001pqr.2	-	4	778	c.577A>G	c.(577-579)ACC>GCC	p.T193A		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	193	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)				T	IGH@	MLCLS								---	---	---	---
PCSK7	9159	broad.mit.edu	37	11	117100293	117100293	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117100293C>T	uc001pqr.2	-	3	469	c.268G>A	c.(268-270)GGA>AGA	p.G90R		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	90					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)				T	IGH@	MLCLS								---	---	---	---
BACE1	23621	broad.mit.edu	37	11	117165972	117165972	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117165972T>C	uc001pqz.2	-	3	903	c.442A>G	c.(442-444)ATC>GTC	p.I148V	BACE1_uc001pqw.2_Missense_Mutation_p.I148V|BACE1_uc001pqx.2_Intron|BACE1_uc001pqy.2_Intron|BACE1_uc001pra.1_Intron|BACE1_uc010rxg.1_Missense_Mutation_p.I48V|BACE1_uc010rxh.1_Missense_Mutation_p.I48V	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	148	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)														---	---	---	---
BACE1	23621	broad.mit.edu	37	11	117186277	117186277	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117186277T>C	uc001pqz.2	-	1	696	c.235A>G	c.(235-237)ATG>GTG	p.M79V	BACE1_uc001pqw.2_Missense_Mutation_p.M79V|BACE1_uc001pqx.2_Missense_Mutation_p.M79V|BACE1_uc001pqy.2_Missense_Mutation_p.M79V|BACE1_uc001pra.1_Missense_Mutation_p.M79V	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	79	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)														---	---	---	---
CEP164	22897	broad.mit.edu	37	11	117279701	117279701	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117279701A>T	uc001prc.2	+	29	3852	c.3705A>T	c.(3703-3705)GAA>GAT	p.E1235D	CEP164_uc001prb.2_Missense_Mutation_p.E1238D|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_Missense_Mutation_p.E668D	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1235					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)														---	---	---	---
DSCAML1	57453	broad.mit.edu	37	11	117301513	117301513	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117301513C>T	uc001prh.1	-	32	5793	c.5791G>A	c.(5791-5793)GCC>ACC	p.A1931T		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1871	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)														---	---	---	---
DSCAML1	57453	broad.mit.edu	37	11	117391895	117391895	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117391895G>A	uc001prh.1	-	6	1345	c.1343C>T	c.(1342-1344)GCT>GTT	p.A448V	DSCAML1_uc001pri.1_Missense_Mutation_p.A252V	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	388	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)														---	---	---	---
MPZL3	196264	broad.mit.edu	37	11	118107987	118107987	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118107987A>G	uc001psm.2	-						MPZL3_uc010rxy.1_Intron|MPZL3_uc010rxz.1_Intron|MPZL3_uc009yzy.2_Intron	NM_198275	NP_938016			myelin protein zero-like 3 precursor						cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
MPZL2	10205	broad.mit.edu	37	11	118133782	118133782	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118133782T>C	uc001psn.2	-	2	230	c.89A>G	c.(88-90)TAT>TGT	p.Y30C	MPZL2_uc001pso.2_Missense_Mutation_p.Y30C|MPZL2_uc001psp.1_Missense_Mutation_p.Y30C	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	30	Extracellular (Potential).|Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118359442	118359442	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118359442T>C	uc001pta.2	+	11	4469	c.4446T>C	c.(4444-4446)TGT>TGC	p.C1482C	MLL_uc001ptb.2_Silent_p.C1482C|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1482	PHD-type 2.|PHD-type 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
MLL	4297	broad.mit.edu	37	11	118374582	118374582	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118374582C>T	uc001pta.2	+	27	7989	c.7966C>T	c.(7966-7968)CGA>TGA	p.R2656*	MLL_uc001ptb.2_Nonsense_Mutation_p.R2659*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2656					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
ARCN1	372	broad.mit.edu	37	11	118454616	118454616	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118454616A>G	uc001ptq.2	+	4	701	c.540A>G	c.(538-540)GCA>GCG	p.A180A	ARCN1_uc009zah.2_Intron|ARCN1_uc010ryg.1_Silent_p.A92A|ARCN1_uc009zag.2_Silent_p.A221A	NM_001655	NP_001646	P48444	COPD_HUMAN	archain isoform 1	180					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	clathrin adaptor complex|COPI vesicle coat|cytosol					0	all_hematologic(175;0.0349)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
PHLDB1	23187	broad.mit.edu	37	11	118514810	118514810	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118514810T>C	uc001ptr.1	+	16	3392	c.3039T>C	c.(3037-3039)AAT>AAC	p.N1013N	PHLDB1_uc001pts.2_Silent_p.N1013N|PHLDB1_uc001ptt.2_Silent_p.N966N|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Silent_p.N813N|PHLDB1_uc001ptw.1_Silent_p.N368N|PHLDB1_uc009zai.1_Silent_p.N49N|PHLDB1_uc001ptx.1_Silent_p.N49N|PHLDB1_uc010ryi.1_Silent_p.N156N|PHLDB1_uc010ryj.1_Silent_p.N151N	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1013											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)														---	---	---	---
BCL9L	283149	broad.mit.edu	37	11	118772844	118772844	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118772844T>C	uc001pug.2	-	6	2573	c.1608A>G	c.(1606-1608)GAA>GAG	p.E536E	BCL9L_uc009zal.2_Silent_p.E531E	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	536					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)														---	---	---	---
SLC37A4	2542	broad.mit.edu	37	11	118895642	118895642	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118895642C>T	uc010rys.1	-	11	2025	c.1268G>A	c.(1267-1269)CGA>CAA	p.R423Q	SLC37A4_uc009zam.2_RNA|SLC37A4_uc009zan.2_RNA|SLC37A4_uc010ryr.1_Missense_Mutation_p.R445Q|SLC37A4_uc010ryt.1_Missense_Mutation_p.R350Q|SLC37A4_uc001pus.2_Missense_Mutation_p.R423Q	NM_001164277	NP_001157749	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate	423					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity|glucose-6-phosphate transmembrane transporter activity			large_intestine(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)										Glycogen_Storage_Disease_type_Ib				---	---	---	---
NLRX1	79671	broad.mit.edu	37	11	119044607	119044607	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119044607G>A	uc001pvu.2	+	5	864	c.649G>A	c.(649-651)GCC>ACC	p.A217T	NLRX1_uc010rzc.1_Missense_Mutation_p.A39T|NLRX1_uc001pvv.2_Missense_Mutation_p.A217T|NLRX1_uc001pvw.2_Missense_Mutation_p.A217T|NLRX1_uc001pvx.2_Missense_Mutation_p.A217T	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	217	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
NLRX1	79671	broad.mit.edu	37	11	119045201	119045201	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119045201C>T	uc001pvu.2	+	6	1104	c.889C>T	c.(889-891)CGT>TGT	p.R297C	NLRX1_uc010rzc.1_Missense_Mutation_p.R119C|NLRX1_uc001pvv.2_Missense_Mutation_p.R297C|NLRX1_uc001pvw.2_Missense_Mutation_p.R297C|NLRX1_uc001pvx.2_Missense_Mutation_p.R297C	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	297	Required for interaction with MAVS.|NACHT.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
NLRX1	79671	broad.mit.edu	37	11	119050643	119050643	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119050643T>C	uc001pvu.2	+	7	2128	c.1913T>C	c.(1912-1914)GTG>GCG	p.V638A	NLRX1_uc010rzc.1_Missense_Mutation_p.V460A|NLRX1_uc001pvv.2_Missense_Mutation_p.V638A|NLRX1_uc001pvw.2_Missense_Mutation_p.V638A|NLRX1_uc001pvx.2_Missense_Mutation_p.V638A	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	638	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
PVRL1	5818	broad.mit.edu	37	11	119547833	119547833	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119547833G>A	uc001pwv.2	-	4	1002	c.830C>T	c.(829-831)GCC>GTC	p.A277V	PVRL1_uc001pwu.1_Missense_Mutation_p.A277V|PVRL1_uc001pww.2_Missense_Mutation_p.A277V	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	277	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)														---	---	---	---
POU2F3	25833	broad.mit.edu	37	11	120175765	120175765	+	Silent	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120175765A>T	uc001pxc.2	+	7	573	c.471A>T	c.(469-471)GGA>GGT	p.G157G	POU2F3_uc010rzk.1_Silent_p.G111G|POU2F3_uc010rzl.1_Silent_p.G87G|POU2F3_uc001pxe.1_5'Flank	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	157					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)														---	---	---	---
TECTA	7007	broad.mit.edu	37	11	120996338	120996338	+	Missense_Mutation	SNP	G	A	A	rs150927084		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120996338G>A	uc010rzo.1	+	7	1531	c.1531G>A	c.(1531-1533)GAC>AAC	p.D511N		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	511	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
SORL1	6653	broad.mit.edu	37	11	121466487	121466487	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121466487T>C	uc001pxx.2	+						SORL1_uc010rzp.1_Intron|SORL1_uc010rzq.1_Intron	NM_003105	NP_003096			sortilin-related receptor containing LDLR class						cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)														---	---	---	---
CRTAM	56253	broad.mit.edu	37	11	122722513	122722513	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122722513C>T	uc001pyj.2	+	3	306	c.306C>T	c.(304-306)AGC>AGT	p.S102S		NM_019604	NP_062550	O95727	CRTAM_HUMAN	class-I MHC-restricted T cell associated	102	Ig-like V-type.|Extracellular (Potential).				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			ovary(1)	1		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)														---	---	---	---
SCN3B	55800	broad.mit.edu	37	11	123508962	123508962	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123508962C>A	uc001pza.1	-	5	923	c.516G>T	c.(514-516)TGG>TGT	p.W172C	SCN3B_uc001pzb.1_Missense_Mutation_p.W172C	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	172	Helical; (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)														---	---	---	---
VWA5A	4013	broad.mit.edu	37	11	124012454	124012454	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124012454T>C	uc001pzu.2	+						VWA5A_uc001pzt.2_Intron	NM_001130142	NP_001123614			BCSC-1 isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
OR8B2	26595	broad.mit.edu	37	11	124252768	124252768	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124252768C>T	uc010sai.1	-	1	472	c.472G>A	c.(472-474)GCC>ACC	p.A158T		NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)														---	---	---	---
TBRG1	84897	broad.mit.edu	37	11	124496881	124496881	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124496881A>C	uc001qak.3	+	5	911	c.673A>C	c.(673-675)ATG>CTG	p.M225L	TBRG1_uc001qaj.3_Missense_Mutation_p.M74L|TBRG1_uc001qal.3_Missense_Mutation_p.M1L|TBRG1_uc001qam.3_RNA|TBRG1_uc009zbf.2_RNA|TBRG1_uc009zbg.2_Missense_Mutation_p.M74L|TBRG1_uc009zbh.2_Missense_Mutation_p.M1L	NM_032811	NP_116200	Q3YBR2	TBRG1_HUMAN	transforming growth factor beta regulator 1	225	FYR N-terminal.				cell cycle arrest|DNA replication|negative regulation of cell proliferation|nucleolus to nucleoplasm transport|protein stabilization	nucleus	DNA binding|protein binding				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0218)														---	---	---	---
ROBO4	54538	broad.mit.edu	37	11	124757724	124757724	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124757724G>A	uc001qbg.2	-	13	2101	c.1961C>T	c.(1960-1962)GCC>GTC	p.A654V	ROBO4_uc010sas.1_Missense_Mutation_p.A509V|ROBO4_uc001qbh.2_Missense_Mutation_p.A544V|ROBO4_uc001qbi.2_Missense_Mutation_p.A212V|ROBO4_uc010sat.1_Missense_Mutation_p.A212V	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	654					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)														---	---	---	---
HEPACAM	220296	broad.mit.edu	37	11	124793613	124793613	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124793613G>A	uc001qbk.2	-						HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Intron	NM_152722	NP_689935			hepatocyte cell adhesion molecule precursor						cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)														---	---	---	---
PKNOX2	63876	broad.mit.edu	37	11	125298986	125298986	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125298986T>C	uc001qbu.2	+	11	1327	c.1013_splice	c.e11+2	p.W338_splice	PKNOX2_uc010saz.1_Splice_Site_p.W309_splice|PKNOX2_uc010sba.1_Splice_Site_p.W309_splice|PKNOX2_uc010sbb.1_Splice_Site_p.W274_splice|PKNOX2_uc001qbv.2_Splice_Site_p.W103_splice	NM_022062	NP_071345			PBX/knotted 1 homeobox 2							nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)												OREG0021475	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
STT3A	3703	broad.mit.edu	37	11	125476321	125476321	+	Silent	SNP	C	T	T	rs1051714		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125476321C>T	uc001qcd.2	+	8	851	c.741C>T	c.(739-741)GGC>GGT	p.G247G	STT3A_uc009zbm.2_Silent_p.G247G|STT3A_uc001qce.2_Silent_p.G247G|STT3A_uc010sbg.1_Silent_p.G155G|STT3A_uc009zbn.2_Silent_p.G21G	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	247	Helical; (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)														---	---	---	---
PATE1	160065	broad.mit.edu	37	11	125618635	125618635	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125618635A>G	uc001qct.2	+	5					PATE1_uc009zbr.2_3'UTR	NM_138294	NP_612151			expressed in prostate and testis precursor							extracellular region					0																		---	---	---	---
CDON	50937	broad.mit.edu	37	11	125880279	125880279	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125880279T>C	uc009zbw.2	-	8	1637	c.1509A>G	c.(1507-1509)GCA>GCG	p.A503A	CDON_uc001qdc.3_Silent_p.A503A|CDON_uc001qdd.3_RNA	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	503	Ig-like C2-type 5.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)														---	---	---	---
FAM118B	79607	broad.mit.edu	37	11	126110831	126110831	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126110831T>C	uc001qdf.2	+	4	414	c.231T>C	c.(229-231)ATT>ATC	p.I77I	FAM118B_uc009zca.2_Silent_p.I81I|FAM118B_uc001qdg.2_Silent_p.I77I	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	77											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)														---	---	---	---
FOXRED1	55572	broad.mit.edu	37	11	126141443	126141443	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126141443T>C	uc001qdi.2	+	2	244	c.197T>C	c.(196-198)GTG>GCG	p.V66A	SRPR_uc001qdh.2_5'Flank|SRPR_uc010sbm.1_5'Flank|FOXRED1_uc010sbn.1_Intron|FOXRED1_uc010sbo.1_Intron|FOXRED1_uc010sbp.1_Intron|FOXRED1_uc010sbq.1_5'UTR|FOXRED1_uc001qdj.2_5'UTR|FOXRED1_uc010sbr.1_Missense_Mutation_p.V52A|FOXRED1_uc001qdk.2_5'UTR	NM_017547	NP_060017	Q96CU9	FXRD1_HUMAN	FAD-dependent oxidoreductase domain containing	66	Helical; (Potential).					integral to membrane|mitochondrion	oxidoreductase activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0729)														---	---	---	---
KIRREL3	84623	broad.mit.edu	37	11	126343330	126343330	+	Silent	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126343330G>C	uc001qea.2	-	5	826	c.465C>G	c.(463-465)GGC>GGG	p.G155G	KIRREL3_uc001qeb.2_Silent_p.G155G|KIRREL3_uc001qec.1_Silent_p.G155G	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	155	Ig-like C2-type 2.|Extracellular (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)														---	---	---	---
TP53AIP1	63970	broad.mit.edu	37	11	128805564	128805564	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:128805564T>A	uc001qey.2	-	4	507	c.297A>T	c.(295-297)ACA>ACT	p.T99T	TP53AIP1_uc001qex.2_3'UTR			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	99					apoptosis	mitochondrion				lung(1)	1																		---	---	---	---
TMEM45B	120224	broad.mit.edu	37	11	129724713	129724713	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129724713T>C	uc001qfe.1	+	3	446	c.385_splice	c.e3+2	p.G129_splice	TMEM45B_uc001qff.1_Splice_Site_p.G129_splice	NM_138788	NP_620143			transmembrane protein 45B							integral to membrane					0	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)														---	---	---	---
ST14	6768	broad.mit.edu	37	11	130079714	130079714	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:130079714T>C	uc001qfw.2	+	19	2757	c.2564T>C	c.(2563-2565)GTA>GCA	p.V855A		NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	855	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)													---	---	---	---
ADAMTS15	170689	broad.mit.edu	37	11	130331434	130331434	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:130331434T>C	uc010scd.1	+	2	1008	c.1008T>C	c.(1006-1008)GGT>GGC	p.G336G		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	336	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)														---	---	---	---
IGSF9B	22997	broad.mit.edu	37	11	133791211	133791211	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:133791211G>T	uc001qgx.3	-	18	2640	c.2409C>A	c.(2407-2409)CCC>CCA	p.P803P		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	803	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)														---	---	---	---
IGSF9B	22997	broad.mit.edu	37	11	133806051	133806051	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:133806051C>T	uc001qgx.3	-	6	949	c.718G>A	c.(718-720)GTC>ATC	p.V240I	IGSF9B_uc001qgy.1_Missense_Mutation_p.V82I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	240	Extracellular (Potential).|Ig-like 3.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)														---	---	---	---
VPS26B	112936	broad.mit.edu	37	11	134114906	134114906	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134114906T>C	uc001qhe.2	+	5	1252	c.796T>C	c.(796-798)TTC>CTC	p.F266L		NM_052875	NP_443107	Q4G0F5	VP26B_HUMAN	vacuolar protein sorting 26 homolog B	266					protein transport|vacuolar transport	cytosol|retromer complex					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;2.43e-10)|all cancers(11;2.94e-09)|BRCA - Breast invasive adenocarcinoma(10;9.57e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00164)|Lung(977;0.216)												OREG0021548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
B3GAT1	27087	broad.mit.edu	37	11	134253954	134253954	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134253954C>T	uc001qhq.2	-	4	502	c.241G>A	c.(241-243)GAC>AAC	p.D81N	B3GAT1_uc001qhr.2_Missense_Mutation_p.D81N|B3GAT1_uc010scv.1_Missense_Mutation_p.D94N	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	81	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)														---	---	---	---
KDM5A	5927	broad.mit.edu	37	12	416989	416989	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:416989G>A	uc001qif.1	-	23	3924	c.3561C>T	c.(3559-3561)AGC>AGT	p.S1187S	KDM5A_uc001qie.1_Silent_p.S1187S	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1187	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3								T 	NUP98	AML								---	---	---	---
B4GALNT3	283358	broad.mit.edu	37	12	667191	667191	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:667191C>T	uc001qii.1	+	17	2544	c.2544C>T	c.(2542-2544)TAC>TAT	p.Y848Y	B4GALNT3_uc001qik.1_Silent_p.Y397Y	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	848	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)															---	---	---	---
WNK1	65125	broad.mit.edu	37	12	1005855	1005855	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1005855G>A	uc001qio.3	+	24	6709	c.6202G>A	c.(6202-6204)GAA>AAA	p.E2068K	WNK1_uc001qip.3_Missense_Mutation_p.E1820K|WNK1_uc001qir.3_Missense_Mutation_p.E1241K	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2068					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)															---	---	---	---
RAD52	5893	broad.mit.edu	37	12	1023614	1023614	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1023614A>G	uc001qis.1	-	10	1064	c.950T>C	c.(949-951)GTG>GCG	p.V317A	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.V240A|RAD52_uc001qiu.1_Missense_Mutation_p.V317A|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	317					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)										Homologous_recombination					---	---	---	---
RAD52	5893	broad.mit.edu	37	12	1034619	1034619	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1034619G>A	uc001qis.1	-	7	654	c.540C>T	c.(538-540)CGC>CGT	p.R180R	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Silent_p.R103R|RAD52_uc001qiu.1_Silent_p.R180R|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Silent_p.R180R|RAD52_uc001qix.1_3'UTR	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	180					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)										Homologous_recombination					---	---	---	---
ERC1	23085	broad.mit.edu	37	12	1221375	1221375	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1221375T>C	uc001qjb.2	+						ERC1_uc001qiz.2_Intron|ERC1_uc001qjc.2_Intron|ERC1_uc001qja.2_Intron|ERC1_uc001qjd.2_Intron|ERC1_uc001qjf.2_Intron|ERC1_uc010sdv.1_Intron|ERC1_uc009zdp.2_Intron	NM_178040	NP_829884			RAB6-interacting protein 2 isoform epsilon						I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)															---	---	---	---
ADIPOR2	79602	broad.mit.edu	37	12	1882025	1882025	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1882025A>G	uc001qjm.2	+	3	386	c.189A>G	c.(187-189)GAA>GAG	p.E63E	ADIPOR2_uc001qjn.2_Silent_p.E63E	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	63	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)															---	---	---	---
ADIPOR2	79602	broad.mit.edu	37	12	1889790	1889790	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1889790C>T	uc001qjm.2	+	5	834	c.637C>T	c.(637-639)CGG>TGG	p.R213W	ADIPOR2_uc001qjn.2_Missense_Mutation_p.R213W	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	213	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)															---	---	---	---
CACNA2D4	93589	broad.mit.edu	37	12	1904931	1904931	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1904931C>T	uc001qjp.2	-	36	3360	c.3129G>A	c.(3127-3129)CAG>CAA	p.Q1043Q	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc001qjo.2_Silent_p.Q186Q|CACNA2D4_uc001qjs.1_Silent_p.Q110Q|CACNA2D4_uc010sdw.1_Silent_p.Q173Q|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	1043	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)														---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2676928	2676928	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2676928C>T	uc009zdu.1	+	13	2176	c.1863C>T	c.(1861-1863)TGC>TGT	p.C621C	CACNA1C_uc009zdv.1_Silent_p.C618C|CACNA1C_uc001qkb.2_Silent_p.C621C|CACNA1C_uc001qkc.2_Silent_p.C621C|CACNA1C_uc001qke.2_Silent_p.C621C|CACNA1C_uc001qkf.2_Silent_p.C621C|CACNA1C_uc001qjz.2_Silent_p.C621C|CACNA1C_uc001qkd.2_Silent_p.C621C|CACNA1C_uc001qkg.2_Silent_p.C621C|CACNA1C_uc009zdw.1_Silent_p.C621C|CACNA1C_uc001qkh.2_Silent_p.C621C|CACNA1C_uc001qkl.2_Silent_p.C621C|CACNA1C_uc001qkn.2_Silent_p.C621C|CACNA1C_uc001qko.2_Silent_p.C621C|CACNA1C_uc001qkp.2_Silent_p.C621C|CACNA1C_uc001qkr.2_Silent_p.C621C|CACNA1C_uc001qku.2_Silent_p.C621C|CACNA1C_uc001qkq.2_Silent_p.C621C|CACNA1C_uc001qks.2_Silent_p.C621C|CACNA1C_uc001qkt.2_Silent_p.C621C|CACNA1C_uc001qka.1_Silent_p.C156C|CACNA1C_uc001qki.1_Silent_p.C357C|CACNA1C_uc001qkj.1_Silent_p.C357C|CACNA1C_uc001qkk.1_Silent_p.C357C|CACNA1C_uc001qkm.1_Silent_p.C357C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	621	II.|Helical; Name=S4 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
CACNA1C	775	broad.mit.edu	37	12	2716226	2716226	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2716226T>C	uc009zdu.1	+	27	3659	c.3346T>C	c.(3346-3348)TTT>CTT	p.F1116L	CACNA1C_uc009zdv.1_Missense_Mutation_p.F1093L|CACNA1C_uc001qkb.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkc.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qke.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkf.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qjz.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkd.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkg.2_Missense_Mutation_p.F1096L|CACNA1C_uc009zdw.1_Missense_Mutation_p.F1096L|CACNA1C_uc001qkh.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkl.2_Missense_Mutation_p.F1116L|CACNA1C_uc001qkn.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qko.2_Missense_Mutation_p.F1116L|CACNA1C_uc001qkp.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkr.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qku.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkq.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qks.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qkt.2_Missense_Mutation_p.F1096L|CACNA1C_uc001qka.1_Missense_Mutation_p.F631L|CACNA1C_uc001qki.1_Missense_Mutation_p.F832L|CACNA1C_uc001qkj.1_Missense_Mutation_p.F832L|CACNA1C_uc001qkk.1_Missense_Mutation_p.F832L|CACNA1C_uc001qkm.1_Missense_Mutation_p.F832L	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1116	Extracellular (Potential).|III.|Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)													---	---	---	---
FKBP4	2288	broad.mit.edu	37	12	2909724	2909724	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2909724C>T	uc001qkz.2	+	8	1211	c.1013C>T	c.(1012-1014)GCC>GTC	p.A338V		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	338	TPR 2.|Interaction with tubulin (By similarity).				negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)													---	---	---	---
ITFG2	55846	broad.mit.edu	37	12	2926419	2926419	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2926419G>A	uc001qlb.1	+	2	191	c.127G>A	c.(127-129)GGG>AGG	p.G43R	ITFG2_uc001qla.1_Missense_Mutation_p.G43R|ITFG2_uc010seb.1_Intron|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	43	FG-GAP 1; atypical.										0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)															---	---	---	---
FOXM1	2305	broad.mit.edu	37	12	2983279	2983279	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:2983279C>T	uc001qlf.2	-	2	631	c.366G>A	c.(364-366)CGG>CGA	p.R122R	FOXM1_uc001qle.2_Silent_p.R122R|FOXM1_uc001qlg.2_Silent_p.R122R|FOXM1_uc009zea.2_Silent_p.R122R|FOXM1_uc009zeb.2_Silent_p.R122R	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	122					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)															---	---	---	---
TEAD4	7004	broad.mit.edu	37	12	3129841	3129841	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3129841C>T	uc010sej.1	+	9	899	c.622C>T	c.(622-624)CCC>TCC	p.P208S	TEAD4_uc010sek.1_Missense_Mutation_p.P165S|TEAD4_uc001qln.2_Missense_Mutation_p.P80S	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	209					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)															---	---	---	---
TEAD4	7004	broad.mit.edu	37	12	3129842	3129842	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3129842C>T	uc010sej.1	+	9	900	c.623C>T	c.(622-624)CCC>CTC	p.P208L	TEAD4_uc010sek.1_Missense_Mutation_p.P165L|TEAD4_uc001qln.2_Missense_Mutation_p.P80L	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	209					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)															---	---	---	---
PRMT8	56341	broad.mit.edu	37	12	3649830	3649830	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3649830G>A	uc001qmf.2	+	2	501	c.134G>A	c.(133-135)TGC>TAC	p.C45Y	PRMT8_uc009zed.2_Missense_Mutation_p.C36Y|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	45					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)															---	---	---	---
AKAP3	10566	broad.mit.edu	37	12	4737718	4737718	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4737718T>C	uc001qnb.3	-	4	579	c.350A>G	c.(349-351)AAC>AGC	p.N117S		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	117					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6																		---	---	---	---
GALNT8	26290	broad.mit.edu	37	12	4870167	4870167	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4870167G>A	uc001qne.1	+	7	1309	c.1217G>A	c.(1216-1218)CGG>CAG	p.R406Q		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	406	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
KCNA1	3736	broad.mit.edu	37	12	5020786	5020786	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5020786T>C	uc001qnh.2	+	2	1347	c.242T>C	c.(241-243)TTC>TCC	p.F81S		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	81					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)													---	---	---	---
KCNA5	3741	broad.mit.edu	37	12	5153912	5153912	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5153912T>C	uc001qni.2	+	1	828	c.599T>C	c.(598-600)ATA>ACA	p.I200T		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	200						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4																		---	---	---	---
NTF3	4908	broad.mit.edu	37	12	5603650	5603650	+	Silent	SNP	C	T	T	rs35988749	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5603650C>T	uc001qnl.3	+	1	353	c.270C>T	c.(268-270)ACC>ACT	p.T90T	NTF3_uc001qnk.3_Silent_p.T103T	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	90					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1																		---	---	---	---
CD27	939	broad.mit.edu	37	12	6559390	6559390	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6559390G>A	uc001qod.2	+	3	531	c.320G>A	c.(319-321)CGC>CAC	p.R107H	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_Intron|LOC678655_uc009zel.1_Intron|CD27_uc001qoe.2_5'UTR|LOC678655_uc009zem.1_Intron|LOC678655_uc001qof.2_Intron|TAPBPL_uc001qog.3_5'Flank|TAPBPL_uc001qoh.3_5'Flank|TAPBPL_uc001qoi.1_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	107	Extracellular (Potential).|TNFR-Cys 3.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0																		---	---	---	---
CD27	939	broad.mit.edu	37	12	6559772	6559772	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6559772C>T	uc001qod.2	+	4	725	c.514C>T	c.(514-516)CGG>TGG	p.R172W	LOC678655_uc001qob.2_Intron|LOC678655_uc001qoc.2_RNA|LOC678655_uc009zel.1_RNA|CD27_uc001qoe.2_Missense_Mutation_p.R22W|LOC678655_uc009zem.1_RNA|LOC678655_uc001qof.2_Intron|TAPBPL_uc001qog.3_5'Flank|TAPBPL_uc001qoh.3_5'Flank|TAPBPL_uc001qoi.1_5'Flank	NM_001242	NP_001233	P26842	CD27_HUMAN	tumor necrosis factor receptor superfamily,	172	Extracellular (Potential).				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity				0																		---	---	---	---
ZNF384	171017	broad.mit.edu	37	12	6778267	6778267	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6778267T>C	uc010sfh.1	-	10	1470	c.1262A>G	c.(1261-1263)CAC>CGC	p.H421R	ZNF384_uc001qpz.2_Missense_Mutation_p.H360R|ZNF384_uc001qqa.2_Missense_Mutation_p.H360R|ZNF384_uc001qqb.2_Missense_Mutation_p.H344R|ZNF384_uc001qqc.2_Missense_Mutation_p.H360R|ZNF384_uc001qqd.2_Missense_Mutation_p.H305R|ZNF384_uc001qqe.2_Missense_Mutation_p.H344R	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	421	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8								T	EWSR1|TAF15 	ALL								---	---	---	---
C12orf57	113246	broad.mit.edu	37	12	7053291	7053291	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7053291T>C	uc001qrz.2	+	1	89	c.7T>C	c.(7-9)TCC>CCC	p.S3P	C12orf57_uc009zfj.1_Intron|PTPN6_uc001qsa.1_5'Flank|PTPN6_uc010sfr.1_5'Flank	NM_138425	NP_612434	Q99622	C10_HUMAN	C10 protein	3											0																OREG0021642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PTPN6	5777	broad.mit.edu	37	12	7066906	7066906	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7066906C>T	uc001qsb.2	+	10	1406	c.1164C>T	c.(1162-1164)ACC>ACT	p.T388T	PTPN6_uc001qsa.1_Silent_p.T390T|PTPN6_uc010sfr.1_Silent_p.T349T|PTPN6_uc009zfl.1_Silent_p.T388T|PTPN6_uc010sfs.1_Silent_p.T376T	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	388	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1																		---	---	---	---
APOBEC1	339	broad.mit.edu	37	12	7805264	7805264	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7805264G>A	uc001qtb.2	-	3	246	c.212C>T	c.(211-213)ACG>ATG	p.T71M	APOBEC1_uc001qtc.2_Missense_Mutation_p.T26M|APOBEC1_uc010sgf.1_Missense_Mutation_p.T71M	NM_001644	NP_001635	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme	71					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding				0																		---	---	---	---
FOXJ2	55810	broad.mit.edu	37	12	8196589	8196589	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8196589C>T	uc001qtu.2	+	5	1605	c.520C>T	c.(520-522)CGG>TGG	p.R174W	FOXJ2_uc001qtt.1_Missense_Mutation_p.R174W	NM_018416	NP_060886	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	174					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				Kidney(36;0.0944)														---	---	---	---
PHC1	1911	broad.mit.edu	37	12	9089487	9089487	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9089487T>C	uc001qvd.2	+	12	2560	c.2404T>C	c.(2404-2406)TAC>CAC	p.Y802H	PHC1_uc001qve.2_Missense_Mutation_p.Y802H	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	802	FCS-type.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
KLRB1	3820	broad.mit.edu	37	12	9754153	9754153	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9754153A>T	uc010sgt.1	-	2	190	c.128T>A	c.(127-129)CTT>CAT	p.L43H		NM_002258	NP_002249	Q12918	KLRB1_HUMAN	killer cell lectin-like receptor subfamily B,	43	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0																		---	---	---	---
CLEC12A	160364	broad.mit.edu	37	12	10137458	10137458	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10137458T>C	uc001qwr.3	+						CLEC12A_uc001qwq.2_Intron|CLEC12A_uc001qws.3_Intron|CLEC12A_uc001qwt.2_Intron	NM_138337	NP_612210			myeloid inhibitory C-type lectin-like receptor							integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1																		---	---	---	---
KLRC2	3822	broad.mit.edu	37	12	10586526	10586526	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10586526T>C	uc001qyk.2	-	4	354	c.347A>G	c.(346-348)CAT>CGT	p.H116R	KLRC3_uc001qyh.2_Intron|KLRC2_uc010she.1_Missense_Mutation_p.H116R	NM_002260	NP_002251	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C,	116	Extracellular (Potential).|C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0																		---	---	---	---
KLRA1	10748	broad.mit.edu	37	12	10748416	10748416	+	RNA	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10748416T>A	uc010shf.1	-	4		c.682A>T			KLRA1_uc010shg.1_RNA|KLRA1_uc009zho.2_RNA|KLRA1_uc009zhn.2_Intron	NM_006611				Homo sapiens Ly-49L (LY49L) mRNA, complete cds.												0																		---	---	---	---
CSDA	8531	broad.mit.edu	37	12	10854626	10854626	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10854626T>C	uc001qyt.2	-	8	1229	c.986A>G	c.(985-987)TAC>TGC	p.Y329C	CSDA_uc001qyu.2_Missense_Mutation_p.Y260C	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	329					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)																	---	---	---	---
PRB3	5544	broad.mit.edu	37	12	11422608	11422608	+	5'UTR	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:11422608C>T	uc001qzs.2	-	1					PRB4_uc001qzf.1_Intron	NM_006249	NP_006240			proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)															---	---	---	---
GPRC5A	9052	broad.mit.edu	37	12	13065434	13065434	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13065434C>T	uc001rba.2	+	4	1685	c.1035C>T	c.(1033-1035)AGC>AGT	p.S345S	uc001rbb.3_5'Flank	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	345	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)													---	---	---	---
KIAA1467	57613	broad.mit.edu	37	12	13215855	13215855	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13215855C>T	uc001rbi.2	+	5	821	c.798C>T	c.(796-798)GAC>GAT	p.D266D	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	266						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)														---	---	---	---
GRIN2B	2904	broad.mit.edu	37	12	13716145	13716145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:13716145A>G	uc001rbt.2	-	13	4206	c.4027T>C	c.(4027-4029)TCA>CCA	p.S1343P		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1343	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)													---	---	---	---
ATF7IP	55729	broad.mit.edu	37	12	14613945	14613945	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14613945T>C	uc001rbw.2	+	9	2833	c.2675T>C	c.(2674-2676)GTG>GCG	p.V892A	ATF7IP_uc010shs.1_3'UTR|ATF7IP_uc001rbu.2_Missense_Mutation_p.V892A|ATF7IP_uc001rbv.1_Missense_Mutation_p.V891A|ATF7IP_uc001rbx.2_Missense_Mutation_p.V891A|ATF7IP_uc010sht.1_3'UTR|ATF7IP_uc001rby.3_Missense_Mutation_p.V892A|ATF7IP_uc001rca.2_Missense_Mutation_p.V892A	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	892					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5																		---	---	---	---
GUCY2C	2984	broad.mit.edu	37	12	14827604	14827604	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14827604T>C	uc001rcd.2	-	8	1176	c.1039A>G	c.(1039-1041)ACC>GCC	p.T347A	GUCY2C_uc009zhz.2_Missense_Mutation_p.T347A	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	347	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6																		---	---	---	---
C12orf60	144608	broad.mit.edu	37	12	14976450	14976450	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14976450T>C	uc001rcj.3	+	2	785	c.581T>C	c.(580-582)GTA>GCA	p.V194A		NM_175874	NP_787070	Q5U649	CL060_HUMAN	hypothetical protein LOC144608	194										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ERP27	121506	broad.mit.edu	37	12	15090939	15090939	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15090939C>T	uc001rco.2	-	2	163	c.142G>A	c.(142-144)GCT>ACT	p.A48T		NM_152321	NP_689534	Q96DN0	ERP27_HUMAN	endoplasmic reticulum protein 27 kDa precursor	48	Thioredoxin.					endoplasmic reticulum lumen				breast(1)	1																		---	---	---	---
RERG	85004	broad.mit.edu	37	12	15264338	15264338	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15264338T>C	uc001rcs.2	-	3	272	c.132A>G	c.(130-132)CGA>CGG	p.R44R	RERG_uc001rct.2_Silent_p.R44R|RERG_uc010shu.1_Silent_p.R25R	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	44					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1																		---	---	---	---
PTPRO	5800	broad.mit.edu	37	12	15734725	15734725	+	Missense_Mutation	SNP	G	A	A	rs146574957		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:15734725G>A	uc001rcv.1	+	23	3419	c.3245G>A	c.(3244-3246)CGG>CAG	p.R1082Q	PTPRO_uc001rcw.1_Missense_Mutation_p.R1054Q|PTPRO_uc001rcx.1_Missense_Mutation_p.R271Q|PTPRO_uc001rcy.1_Missense_Mutation_p.R271Q|PTPRO_uc001rcz.1_Missense_Mutation_p.R243Q|PTPRO_uc001rda.1_Missense_Mutation_p.R243Q	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	1082	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)																---	---	---	---
PDE3A	5139	broad.mit.edu	37	12	20766423	20766423	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20766423C>G	uc001reh.1	+	3	1080	c.1058C>G	c.(1057-1059)GCC>GGC	p.A353G		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	353					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)													---	---	---	---
PDE3A	5139	broad.mit.edu	37	12	20792787	20792787	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20792787A>G	uc001reh.1	+	10	2169	c.2147A>G	c.(2146-2148)TAC>TGC	p.Y716C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	716					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)													---	---	---	---
PDE3A	5139	broad.mit.edu	37	12	20799759	20799759	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20799759T>A	uc001reh.1	+	12	2462	c.2440T>A	c.(2440-2442)TAC>AAC	p.Y814N		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	814	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)													---	---	---	---
SLCO1B3	28234	broad.mit.edu	37	12	21015500	21015500	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21015500A>G	uc001rek.2	+						SLCO1B3_uc001rel.2_Intron|SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Intron	NM_019844	NP_062818			solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)																	---	---	---	---
LST-3TM12	338821	broad.mit.edu	37	12	21174422	21174422	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21174422T>C	uc010sin.1	+	3	246	c.246T>C	c.(244-246)ATT>ATC	p.I82I	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.I129I	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	82						membrane	transporter activity				0																		---	---	---	---
SLCO1B3	28234	broad.mit.edu	37	12	21229407	21229407	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21229407A>G	uc010sil.1	+	15	2017	c.1952A>G	c.(1951-1953)TAT>TGT	p.Y651C	LST-3TM12_uc010sim.1_Missense_Mutation_p.Y590C|LST-3TM12_uc010sin.1_Missense_Mutation_p.Y543C			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)																	---	---	---	---
SLCO1B1	10599	broad.mit.edu	37	12	21375266	21375266	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21375266T>C	uc001req.3	+	13	1819	c.1715T>C	c.(1714-1716)CTG>CCG	p.L572P		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	572	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)													---	---	---	---
RECQL	5965	broad.mit.edu	37	12	21623156	21623156	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21623156G>T	uc001rex.2	-	16	2270	c.1922C>A	c.(1921-1923)GCT>GAT	p.A641D	RECQL_uc001rey.2_Missense_Mutation_p.A641D|PYROXD1_uc001rew.2_3'UTR|PYROXD1_uc009ziq.2_3'UTR|PYROXD1_uc009zir.2_3'UTR	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	641					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2													Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
LDHB	3945	broad.mit.edu	37	12	21788591	21788591	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21788591T>C	uc001rfc.2	-	7	908	c.890A>G	c.(889-891)AAT>AGT	p.N297S	LDHB_uc001rfd.2_Missense_Mutation_p.N297S|LDHB_uc001rfe.2_Missense_Mutation_p.N297S	NM_002300	NP_002291	P07195	LDHB_HUMAN	L-lactate dehydrogenase B	297					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity			breast(2)|ovary(1)	3					NADH(DB00157)													---	---	---	---
KCNJ8	3764	broad.mit.edu	37	12	21919133	21919133	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21919133T>C	uc001rff.2	-	3	1137	c.799A>G	c.(799-801)ATC>GTC	p.I267V		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	267	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)													---	---	---	---
ABCC9	10060	broad.mit.edu	37	12	21970154	21970154	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21970154T>C	uc001rfi.1	-	31	3879	c.3859A>G	c.(3859-3861)ACT>GCT	p.T1287A	ABCC9_uc001rfh.2_Missense_Mutation_p.T1287A|ABCC9_uc001rfj.1_Missense_Mutation_p.T1251A	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1287	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
ABCC9	10060	broad.mit.edu	37	12	22061055	22061055	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22061055A>G	uc001rfi.1	-	9	1431	c.1411T>C	c.(1411-1413)TAC>CAC	p.Y471H	ABCC9_uc001rfh.2_Missense_Mutation_p.Y471H|ABCC9_uc001rfj.1_Missense_Mutation_p.Y471H	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	471	ABC transmembrane type-1 1.|Helical; Name=9; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
SOX5	6660	broad.mit.edu	37	12	23716308	23716308	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:23716308T>C	uc001rfw.2	-	11	1474	c.1372A>G	c.(1372-1374)AAG>GAG	p.K458E	SOX5_uc001rfx.2_Missense_Mutation_p.K445E|SOX5_uc001rfy.2_Intron|SOX5_uc001rfv.2_Missense_Mutation_p.K72E|SOX5_uc010siv.1_Missense_Mutation_p.K445E|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Missense_Mutation_p.K410E	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	458	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6																		---	---	---	---
SOX5	6660	broad.mit.edu	37	12	23893942	23893942	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:23893942C>T	uc001rfw.2	-	5	702	c.600G>A	c.(598-600)AGG>AGA	p.R200R	SOX5_uc001rfx.2_Silent_p.R187R|SOX5_uc001rfy.2_Silent_p.R187R|SOX5_uc010siv.1_Silent_p.R187R|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Silent_p.R152R	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	200	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6																		---	---	---	---
BCAT1	586	broad.mit.edu	37	12	25002718	25002718	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:25002718A>G	uc001rgd.3	-	6	1116	c.674_splice	c.e6+1	p.G225_splice	BCAT1_uc001rgc.2_Splice_Site_p.G224_splice|BCAT1_uc010six.1_Splice_Site_p.G237_splice|BCAT1_uc010siy.1_Splice_Site_p.G188_splice|BCAT1_uc001rge.3_Splice_Site_p.G164_splice	NM_005504	NP_005495			branched chain aminotransferase 1, cytosolic						branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)													---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26714699	26714699	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26714699A>G	uc001rhg.2	-	35	5234	c.4817T>C	c.(4816-4818)TTA>TCA	p.L1606S		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1606	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
FGFR1OP2	26127	broad.mit.edu	37	12	27107161	27107161	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27107161G>A	uc001rhm.2	+	2	412	c.70G>A	c.(70-72)GAT>AAT	p.D24N	FGFR1OP2_uc001rhl.2_Missense_Mutation_p.D24N|FGFR1OP2_uc001rhn.2_Missense_Mutation_p.D24N	NM_015633	NP_056448	Q9NVK5	FGOP2_HUMAN	FGFR1 oncogene partner 2	24	Potential.					cytoplasm					0	Colorectal(261;0.0847)																	---	---	---	---
STK38L	23012	broad.mit.edu	37	12	27475266	27475266	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27475266A>G	uc001rhr.2	+	14	1472	c.1273A>G	c.(1273-1275)AAT>GAT	p.N425D	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.N332D|STK38L_uc010sjn.1_Missense_Mutation_p.N163D|STK38L_uc010sjo.1_Missense_Mutation_p.N90D	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	425	AGC-kinase C-terminal.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27824360	27824360	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27824360A>G	uc001ric.1	+						PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Intron|PPFIBP1_uc001ria.2_Intron|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613			PTPRF interacting protein binding protein 1						cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
FAR2	55711	broad.mit.edu	37	12	29485561	29485561	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29485561A>G	uc001ris.3	+	11	1433	c.1286A>G	c.(1285-1287)AAC>AGC	p.N429S	FAR2_uc001rit.2_Missense_Mutation_p.N429S|FAR2_uc009zjm.2_Missense_Mutation_p.N332S	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	429					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0																		---	---	---	---
ERGIC2	51290	broad.mit.edu	37	12	29524548	29524548	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:29524548T>C	uc001riv.2	-	2	152	c.19A>G	c.(19-21)AAA>GAA	p.K7E	ERGIC2_uc001riw.2_RNA	NM_016570	NP_057654	Q96RQ1	ERGI2_HUMAN	PTX1 protein	7	Cytoplasmic (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				ovary(1)	1	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)													---	---	---	---
IPO8	10526	broad.mit.edu	37	12	30814171	30814171	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:30814171A>G	uc001rjd.2	-	16	1955	c.1785T>C	c.(1783-1785)AGT>AGC	p.S595S	IPO8_uc001rje.1_Silent_p.S84S|IPO8_uc010sjt.1_Silent_p.S390S	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	595					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)																	---	---	---	---
IPO8	10526	broad.mit.edu	37	12	30815390	30815390	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:30815390A>G	uc001rjd.2	-	15	1796	c.1626T>C	c.(1624-1626)CCT>CCC	p.P542P	IPO8_uc001rje.1_Silent_p.P31P|IPO8_uc010sjt.1_Silent_p.P337P	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	542					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)																	---	---	---	---
CAPRIN2	65981	broad.mit.edu	37	12	30873765	30873765	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:30873765T>A	uc001rji.1	-	12	2879	c.2128A>T	c.(2128-2130)ATG>TTG	p.M710L	CAPRIN2_uc001rjf.1_Missense_Mutation_p.M507L|CAPRIN2_uc001rjg.1_Missense_Mutation_p.M377L|CAPRIN2_uc001rjh.1_Missense_Mutation_p.M710L|CAPRIN2_uc001rjj.1_Missense_Mutation_p.M377L|CAPRIN2_uc001rjk.3_Missense_Mutation_p.M710L|CAPRIN2_uc001rjl.3_Intron|CAPRIN2_uc001rjm.1_Intron	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	710					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)																	---	---	---	---
DENND5B	160518	broad.mit.edu	37	12	31545266	31545266	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31545266A>G	uc001rki.1	-	19	3587	c.3401T>C	c.(3400-3402)GTT>GCT	p.V1134A	DENND5B_uc001rkh.1_Missense_Mutation_p.V1169A|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1134	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
FGD4	121512	broad.mit.edu	37	12	32754251	32754251	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32754251T>C	uc001rkz.2	+	6	1207	c.730T>C	c.(730-732)TCG>CCG	p.S244P	FGD4_uc001rlc.2_Missense_Mutation_p.S329P|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Missense_Mutation_p.S356P|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	244	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)																	---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39703510	39703510	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39703510A>G	uc001rly.2	-	33	4301	c.4155T>C	c.(4153-4155)GGT>GGC	p.G1385G	KIF21A_uc001rlv.2_Silent_p.G330G|KIF21A_uc001rlw.2_Silent_p.G655G|KIF21A_uc001rlx.2_Silent_p.G1372G|KIF21A_uc001rlz.2_Silent_p.G1332G|KIF21A_uc010skl.1_Silent_p.G1348G|KIF21A_uc001rlt.2_Silent_p.G5G|KIF21A_uc001rlu.2_Silent_p.G5G	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1385	WD 2.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
ABCD2	225	broad.mit.edu	37	12	40013362	40013362	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40013362G>T	uc001rmb.2	-	1	482	c.56C>A	c.(55-57)GCT>GAT	p.A19D		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	19	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
C12orf40	283461	broad.mit.edu	37	12	40040225	40040225	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40040225T>C	uc001rmc.2	+	4	464	c.297T>C	c.(295-297)TGT>TGC	p.C99C	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	99										ovary(6)	6																		---	---	---	---
SLC2A13	114134	broad.mit.edu	37	12	40223949	40223949	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40223949A>G	uc010skm.1	-	7	1452	c.1401T>C	c.(1399-1401)TGT>TGC	p.C467C	C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Silent_p.C114C	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	467	Extracellular (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)													HNSCC(50;0.14)			---	---	---	---
PDZRN4	29951	broad.mit.edu	37	12	41585354	41585354	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:41585354A>G	uc010skn.1	+							NM_013377	NP_037509			PDZ domain containing RING finger 4 isoform 2								ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)																---	---	---	---
PPHLN1	51535	broad.mit.edu	37	12	42729685	42729685	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42729685T>C	uc001rng.1	+	2					PPHLN1_uc001rmy.2_Missense_Mutation_p.V12A|PPHLN1_uc001rna.2_Missense_Mutation_p.M1T|PPHLN1_uc001rne.2_Missense_Mutation_p.M1T|PPHLN1_uc001rnb.2_Missense_Mutation_p.M1T|PPHLN1_uc001rnd.2_Missense_Mutation_p.M1T|PPHLN1_uc001rnc.2_5'UTR|PPHLN1_uc001rnf.2_5'UTR|PPHLN1_uc010skq.1_5'UTR|PPHLN1_uc010skr.1_5'UTR|PPHLN1_uc010sks.1_5'UTR|PPHLN1_uc010skt.1_Intron|PPHLN1_uc001rni.1_5'UTR|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Missense_Mutation_p.M1T	NM_016488	NP_057572			periphilin 1 isoform 1						keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)														---	---	---	---
PRICKLE1	144165	broad.mit.edu	37	12	42853620	42853620	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42853620A>G	uc010skv.1	-	8	2774	c.2487T>C	c.(2485-2487)ATT>ATC	p.I829I	PRICKLE1_uc001rnl.2_Silent_p.I829I|PRICKLE1_uc010skw.1_Silent_p.I829I|PRICKLE1_uc001rnm.2_Silent_p.I829I|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	829				Missing: Abolishes localization to the nuclear membrane.	negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)														---	---	---	---
PRICKLE1	144165	broad.mit.edu	37	12	42853889	42853889	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:42853889C>T	uc010skv.1	-	8	2505	c.2218G>A	c.(2218-2220)GAT>AAT	p.D740N	PRICKLE1_uc001rnl.2_Missense_Mutation_p.D740N|PRICKLE1_uc010skw.1_Missense_Mutation_p.D740N|PRICKLE1_uc001rnm.2_Missense_Mutation_p.D740N|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	740					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)														---	---	---	---
ADAMTS20	80070	broad.mit.edu	37	12	43792885	43792885	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:43792885G>A	uc010skx.1	-	29	4436	c.4436C>T	c.(4435-4437)GCC>GTC	p.A1479V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1479	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)														---	---	---	---
PUS7L	83448	broad.mit.edu	37	12	44136258	44136258	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44136258A>G	uc001rnq.3	-	5	1851	c.1362_splice	c.e5+1	p.M454_splice	PUS7L_uc001rnr.3_Splice_Site_p.M454_splice|PUS7L_uc001rns.3_Splice_Site_p.M454_splice|PUS7L_uc009zkb.2_Splice_Site_p.M141_splice	NM_001098615	NP_001092085			pseudouridylate synthase 7 homolog (S.						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)														---	---	---	---
TMEM117	84216	broad.mit.edu	37	12	44782204	44782204	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44782204A>G	uc001rod.2	+	8	1360	c.1294A>G	c.(1294-1296)ACT>GCT	p.T432A	TMEM117_uc001roe.2_Missense_Mutation_p.T328A|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	432						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)														---	---	---	---
NELL2	4753	broad.mit.edu	37	12	45170874	45170874	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45170874A>G	uc001rog.2	-	7	1308	c.713T>C	c.(712-714)GTG>GCG	p.V238A	NELL2_uc001rof.3_Missense_Mutation_p.V237A|NELL2_uc001roh.2_Missense_Mutation_p.V238A|NELL2_uc009zkd.2_Missense_Mutation_p.V237A|NELL2_uc010skz.1_Missense_Mutation_p.V288A|NELL2_uc010sla.1_Missense_Mutation_p.V261A|NELL2_uc001roi.1_Missense_Mutation_p.V238A|NELL2_uc010slb.1_Missense_Mutation_p.V237A|NELL2_uc001roj.2_Missense_Mutation_p.V238A	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	238	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)														---	---	---	---
ANO6	196527	broad.mit.edu	37	12	45771863	45771863	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:45771863A>G	uc001roo.2	+	10	1467	c.1132A>G	c.(1132-1134)ACC>GCC	p.T378A	ANO6_uc010sld.1_Missense_Mutation_p.T378A|ANO6_uc010sle.1_Missense_Mutation_p.T378A|ANO6_uc010slf.1_Missense_Mutation_p.T399A|ANO6_uc010slg.1_Missense_Mutation_p.T360A	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	378	Helical; (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2																		---	---	---	---
SFRS2IP	9169	broad.mit.edu	37	12	46316821	46316821	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46316821C>T	uc001rox.2	-	13	4310	c.4023G>A	c.(4021-4023)TCG>TCA	p.S1341S	SFRS2IP_uc001row.2_Silent_p.S1026S	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1341					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)														---	---	---	---
SFRS2IP	9169	broad.mit.edu	37	12	46322023	46322023	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46322023A>G	uc001rox.2	-	11	1748	c.1461T>C	c.(1459-1461)GGT>GGC	p.G487G	SFRS2IP_uc001row.2_Silent_p.G172G|SFRS2IP_uc001roy.1_Silent_p.G561G	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	487					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)														---	---	---	---
SLC38A2	54407	broad.mit.edu	37	12	46756417	46756417	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46756417C>T	uc001rpg.2	-	14	1624	c.1184G>A	c.(1183-1185)CGG>CAG	p.R395Q	SLC38A2_uc010sli.1_Missense_Mutation_p.R233Q|SLC38A2_uc001rph.2_Missense_Mutation_p.R295Q	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	395	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)														---	---	---	---
SLC38A2	54407	broad.mit.edu	37	12	46758170	46758170	+	Splice_Site	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46758170A>T	uc001rpg.2	-	10	1313	c.873_splice	c.e10+1	p.Q291_splice	SLC38A2_uc010sli.1_Splice_Site_p.Q129_splice|SLC38A2_uc001rph.2_Splice_Site_p.Q191_splice	NM_018976	NP_061849			solute carrier family 38, member 2						cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)														---	---	---	---
SLC38A2	54407	broad.mit.edu	37	12	46758283	46758283	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46758283G>A	uc001rpg.2	-	10	1202	c.762C>T	c.(760-762)AAC>AAT	p.N254N	SLC38A2_uc010sli.1_Silent_p.N92N|SLC38A2_uc001rph.2_Silent_p.N154N	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	254	Extracellular (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)														---	---	---	---
AMIGO2	347902	broad.mit.edu	37	12	47471555	47471555	+	Missense_Mutation	SNP	C	T	T	rs77621437	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47471555C>T	uc001rpm.2	-	3	1886	c.1231G>A	c.(1231-1233)GTT>ATT	p.V411I	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.V411I|AMIGO2_uc001rpl.2_Missense_Mutation_p.V411I	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	411	Helical; (Potential).				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)																	---	---	---	---
FAM113B	91523	broad.mit.edu	37	12	47628862	47628862	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47628862G>A	uc001rpn.2	+	4	747	c.16G>A	c.(16-18)GCC>ACC	p.A6T	FAM113B_uc010slj.1_Intron|FAM113B_uc001rpq.2_Missense_Mutation_p.A6T	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	6							hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)																	---	---	---	---
FAM113B	91523	broad.mit.edu	37	12	47629856	47629856	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47629856C>T	uc001rpn.2	+	4	1741	c.1010C>T	c.(1009-1011)CCC>CTC	p.P337L	FAM113B_uc001rpq.2_Missense_Mutation_p.P337L	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	337	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)																	---	---	---	---
ADCY6	112	broad.mit.edu	37	12	49170029	49170029	+	Missense_Mutation	SNP	A	G	G	rs143114060	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49170029A>G	uc001rsh.3	-	7	2300	c.1640T>C	c.(1639-1641)ATT>ACT	p.I547T	ADCY6_uc001rsj.3_Missense_Mutation_p.I547T|ADCY6_uc001rsi.3_Missense_Mutation_p.I547T|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	547	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0																		---	---	---	---
PRKAG1	5571	broad.mit.edu	37	12	49399287	49399287	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49399287G>A	uc001rsy.2	-	4	277	c.208C>T	c.(208-210)CGA>TGA	p.R70*	uc001rsw.2_Intron|PRKAG1_uc010smd.1_Nonsense_Mutation_p.R38*|PRKAG1_uc001rsx.2_Translation_Start_Site|PRKAG1_uc001rsz.2_Nonsense_Mutation_p.R70*|PRKAG1_uc009zlb.2_Translation_Start_Site|PRKAG1_uc010sme.1_Nonsense_Mutation_p.R70*	NM_002733	NP_002724	P54619	AAKG1_HUMAN	AMP-activated protein kinase, noncatalytic	70	CBS 1.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			kidney(1)	1																		---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49434235	49434235	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49434235C>T	uc001rta.3	-	31	7318	c.7318G>A	c.(7318-7320)GTT>ATT	p.V2440I		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2440	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49434729	49434729	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49434729G>A	uc001rta.3	-	31	6824	c.6824C>T	c.(6823-6825)CCC>CTC	p.P2275L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2275	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
LMBR1L	55716	broad.mit.edu	37	12	49499707	49499707	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49499707G>A	uc001rth.3	-	3	533	c.191C>T	c.(190-192)GCG>GTG	p.A64V	LMBR1L_uc001rtg.3_Missense_Mutation_p.A59V|LMBR1L_uc001rti.3_Missense_Mutation_p.A64V|LMBR1L_uc001rtj.1_5'Flank|LMBR1L_uc009zld.1_5'UTR|LMBR1L_uc010smf.1_Intron	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	64	LCN1-binding.|Cytoplasmic (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1																		---	---	---	---
PRPH	5630	broad.mit.edu	37	12	49689976	49689976	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49689976G>A	uc001rtu.2	+	2	636	c.561G>A	c.(559-561)ACG>ACA	p.T187T		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	187	Coil 1B.|Rod.						structural molecule activity				0																		---	---	---	---
NCKAP5L	57701	broad.mit.edu	37	12	50196941	50196941	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50196941T>G	uc009zlk.2	-	4	333	c.131A>C	c.(130-132)AAC>ACC	p.N44T		NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	40	Potential.									central_nervous_system(1)	1																		---	---	---	---
GPD1	2819	broad.mit.edu	37	12	50500173	50500173	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50500173G>A	uc001rvz.2	+	4	496	c.463G>A	c.(463-465)GAG>AAG	p.E155K	GPD1_uc001rwa.2_Missense_Mutation_p.E132K	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	155					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)													---	---	---	---
LARP4	113251	broad.mit.edu	37	12	50847269	50847269	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:50847269T>C	uc001rwp.1	+	9	975	c.831T>C	c.(829-831)TTT>TTC	p.F277F	LARP4_uc001rwo.1_Silent_p.F283F|LARP4_uc001rwq.1_Intron|LARP4_uc001rwr.1_Silent_p.F277F|LARP4_uc001rws.1_Silent_p.F276F|LARP4_uc009zlr.1_Silent_p.F96F|LARP4_uc001rwt.1_Intron|LARP4_uc001rwm.2_Silent_p.F277F|LARP4_uc001rwn.2_Silent_p.F207F	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	277	RRM.						nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
DIP2B	57609	broad.mit.edu	37	12	51034587	51034587	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51034587T>C	uc001rwv.2	+	3	409	c.253T>C	c.(253-255)TAC>CAC	p.Y85H	DIP2B_uc001rwu.2_Missense_Mutation_p.Y85H|DIP2B_uc009zls.1_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	85						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6																		---	---	---	---
LETMD1	25875	broad.mit.edu	37	12	51449688	51449688	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51449688A>G	uc001rxm.2	+	5	600	c.544A>G	c.(544-546)ATC>GTC	p.I182V	LETMD1_uc010smz.1_Missense_Mutation_p.I132V|LETMD1_uc010sna.1_Intron|LETMD1_uc001rxl.2_Missense_Mutation_p.I126V|LETMD1_uc009zlv.2_Intron|LETMD1_uc001rxs.2_Intron|LETMD1_uc009zlw.2_Missense_Mutation_p.I195V|LETMD1_uc001rxn.2_Missense_Mutation_p.I25V|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Missense_Mutation_p.I65V|LETMD1_uc001rxq.2_Intron|LETMD1_uc001rxr.2_Intron|LETMD1_uc001rxt.2_Intron	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	182	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2																		---	---	---	---
CSRNP2	81566	broad.mit.edu	37	12	51458364	51458364	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51458364C>T	uc001rxu.1	-	5	1095	c.797G>A	c.(796-798)CGG>CAG	p.R266Q		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	266					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
POU6F1	5463	broad.mit.edu	37	12	51590631	51590631	+	5'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51590631G>A	uc001rxy.2	-	1					POU6F1_uc001rxz.2_5'UTR|POU6F1_uc001rya.2_5'UTR	NM_002702	NP_002693			POU class 6 homeobox 1						brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
SLC4A8	9498	broad.mit.edu	37	12	51882561	51882561	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51882561C>A	uc001rys.1	+	18	2543	c.2365C>A	c.(2365-2367)CCA>ACA	p.P789T	SLC4A8_uc001rym.2_Missense_Mutation_p.P736T|SLC4A8_uc001ryn.2_Missense_Mutation_p.P736T|SLC4A8_uc001ryo.2_Missense_Mutation_p.P736T|SLC4A8_uc010snj.1_Missense_Mutation_p.P816T|SLC4A8_uc001ryr.2_Missense_Mutation_p.P789T	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	789	Helical; (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)														---	---	---	---
SCN8A	6334	broad.mit.edu	37	12	52156379	52156379	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52156379C>T	uc001ryw.2	+	15	2641	c.2463C>T	c.(2461-2463)GAC>GAT	p.D821D	SCN8A_uc010snl.1_Silent_p.D686D|SCN8A_uc001ryy.2_Silent_p.D686D	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	821	Helical; Name=S3 of repeat II; (Potential).|II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)													---	---	---	---
KRT80	144501	broad.mit.edu	37	12	52566892	52566892	+	Missense_Mutation	SNP	C	T	T	rs141107117		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52566892C>T	uc001rzx.2	-	6	985	c.887G>A	c.(886-888)CGC>CAC	p.R296H	KRT80_uc001rzw.2_Missense_Mutation_p.R331H|KRT80_uc001rzy.2_Missense_Mutation_p.R296H	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	296	Rod.|Coil 2.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)														---	---	---	---
KRT83	3889	broad.mit.edu	37	12	52714818	52714818	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52714818T>C	uc001saf.2	-	1	365	c.302A>G	c.(301-303)GAC>GGC	p.D101G		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	101	Head.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)														---	---	---	---
KRT82	3888	broad.mit.edu	37	12	52800051	52800051	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52800051T>A	uc001sai.1	-	1	126	c.11A>T	c.(10-12)CAC>CTC	p.H4L		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	4	Head.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)														---	---	---	---
KRT6A	3853	broad.mit.edu	37	12	52881872	52881872	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52881872G>A	uc001sam.2	-	8	1649	c.1440C>T	c.(1438-1440)GGC>GGT	p.G480G		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	480	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)														---	---	---	---
KRT1	3848	broad.mit.edu	37	12	53069123	53069123	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53069123C>T	uc001sau.1	-	9	1848	c.1789G>A	c.(1789-1791)GGC>AGC	p.G597S	KRT1_uc001sav.1_Missense_Mutation_p.G590S	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	597	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2																		---	---	---	---
TENC1	23371	broad.mit.edu	37	12	53449467	53449467	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53449467A>G	uc001sbp.2	+	9	824	c.689A>G	c.(688-690)TAC>TGC	p.Y230C	uc001sbk.1_5'Flank|TENC1_uc001sbl.2_Missense_Mutation_p.Y106C|TENC1_uc001sbm.2_Missense_Mutation_p.Y240C|TENC1_uc001sbn.2_Missense_Mutation_p.Y240C|TENC1_uc001sbo.1_Missense_Mutation_p.Y230C|TENC1_uc001sbq.2_5'Flank|TENC1_uc001sbr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	230	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2																		---	---	---	---
TENC1	23371	broad.mit.edu	37	12	53455004	53455004	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53455004T>C	uc001sbp.2	+	20	3449	c.3314T>C	c.(3313-3315)GTC>GCC	p.V1105A	TENC1_uc001sbl.2_Missense_Mutation_p.V981A|TENC1_uc001sbn.2_Missense_Mutation_p.V1115A|TENC1_uc001sbq.2_Missense_Mutation_p.V503A|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Missense_Mutation_p.V600A|TENC1_uc001sbs.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1105	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2																		---	---	---	---
TENC1	23371	broad.mit.edu	37	12	53456009	53456009	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53456009G>A	uc001sbp.2	+	23	3782	c.3647G>A	c.(3646-3648)TGC>TAC	p.C1216Y	TENC1_uc001sbl.2_Missense_Mutation_p.C1092Y|TENC1_uc001sbn.2_Missense_Mutation_p.C1226Y|TENC1_uc001sbq.2_Missense_Mutation_p.C614Y|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Missense_Mutation_p.C711Y|TENC1_uc001sbs.2_5'UTR	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1216	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2																		---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53671610	53671610	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53671610T>C	uc001sck.2	+	11	2321	c.2230T>C	c.(2230-2232)TCC>CCC	p.S744P	ESPL1_uc001scj.2_Missense_Mutation_p.S419P|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	744					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
ESPL1	9700	broad.mit.edu	37	12	53677233	53677233	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53677233C>T	uc001sck.2	+	16	3079	c.2988C>T	c.(2986-2988)TGC>TGT	p.C996C	ESPL1_uc001scj.2_Silent_p.C671C|ESPL1_uc010soe.1_Silent_p.C207C	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	996					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3																		---	---	---	---
C12orf10	60314	broad.mit.edu	37	12	53696953	53696953	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53696953C>T	uc001scp.3	+	3	517	c.465C>T	c.(463-465)AGC>AGT	p.S155S	C12orf10_uc010sof.1_Silent_p.S155S|C12orf10_uc009zmx.2_Silent_p.S155S|C12orf10_uc001scq.3_Silent_p.S40S	NM_021640	NP_067653	Q86UA3	Q86UA3_HUMAN	MYG1 protein precursor	155										ovary(2)	2																		---	---	---	---
HOXC8	3224	broad.mit.edu	37	12	54403221	54403221	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54403221C>T	uc001ser.2	+	1	332	c.153C>T	c.(151-153)CAC>CAT	p.H51H		NM_022658	NP_073149	P31273	HXC8_HUMAN	homeobox C8	51						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
ITGA5	3678	broad.mit.edu	37	12	54799103	54799103	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:54799103G>A	uc001sga.2	-	12	1140	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	358	Extracellular (Potential).|FG-GAP 5.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2																		---	---	---	---
KIAA0748	9840	broad.mit.edu	37	12	55356581	55356581	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55356581T>C	uc001sgn.3	-	9	1211	c.1101A>G	c.(1099-1101)GAA>GAG	p.E367E	KIAA0748_uc001sgl.3_Silent_p.E229E|KIAA0748_uc001sgm.3_Silent_p.E114E|KIAA0748_uc010spb.1_Silent_p.E114E|KIAA0748_uc010spc.1_Silent_p.E229E|KIAA0748_uc010spd.1_Silent_p.E367E|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	367										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ITGA7	3679	broad.mit.edu	37	12	56092633	56092633	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56092633G>A	uc001shh.2	-	6	1091	c.871C>T	c.(871-873)CGC>TGC	p.R291C	ITGA7_uc001shg.2_Missense_Mutation_p.R287C|ITGA7_uc010sps.1_Missense_Mutation_p.R194C|ITGA7_uc009znw.2_5'Flank|ITGA7_uc009znx.2_Missense_Mutation_p.R174C	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	331	FG-GAP 4.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
RDH5	5959	broad.mit.edu	37	12	56115741	56115741	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56115741A>G	uc001shk.2	+						BLOC1S1_uc001shj.3_3'UTR|RDH5_uc010spt.1_3'UTR|RDH5_uc010spu.1_3'UTR|RDH5_uc001shl.2_Intron	NM_002905	NP_002896			retinol dehydrogenase 5 (11-cis and 9-cis)						response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			ovary(1)	1					NADH(DB00157)|Vitamin A(DB00162)													---	---	---	---
DNAJC14	85406	broad.mit.edu	37	12	56221972	56221972	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56221972A>G	uc001shx.1	-	2	675	c.471T>C	c.(469-471)TGT>TGC	p.C157C	DNAJC14_uc001shu.1_Silent_p.C157C|DNAJC14_uc009zob.1_Silent_p.C157C|DNAJC14_uc001shy.1_Silent_p.C157C	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	157					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4																		---	---	---	---
IKZF4	64375	broad.mit.edu	37	12	56428913	56428913	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56428913T>C	uc001sjb.1	+	9	1715	c.1556T>C	c.(1555-1557)GTG>GCG	p.V519A	IKZF4_uc010sqa.1_Missense_Mutation_p.V472A|IKZF4_uc001sjc.1_Missense_Mutation_p.V519A|IKZF4_uc001sjd.1_Missense_Mutation_p.V417A|IKZF4_uc009zoi.1_Missense_Mutation_p.V474A|IKZF4_uc001sje.1_Missense_Mutation_p.V478A	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	519					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
ERBB3	2065	broad.mit.edu	37	12	56481863	56481863	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56481863T>C	uc001sjh.2	+	7	984	c.791T>C	c.(790-792)GTC>GCC	p.V264A	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V205A|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	264	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)															---	---	---	---
PA2G4	5036	broad.mit.edu	37	12	56505008	56505008	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56505008C>A	uc001sjm.2	+	11	1399	c.980C>A	c.(979-981)CCC>CAC	p.P327H	PA2G4_uc009zol.2_Missense_Mutation_p.P327H|PA2G4_uc009zom.2_Intron	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	327	Necessary for nucleolar localization.				cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)															---	---	---	---
ZC3H10	84872	broad.mit.edu	37	12	56515016	56515016	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56515016T>C	uc001sjp.1	+	3	859	c.670T>C	c.(670-672)TCA>CCA	p.S224P		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	224							nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)															---	---	---	---
SMARCC2	6601	broad.mit.edu	37	12	56563585	56563585	+	Silent	SNP	G	A	A	rs148688009	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56563585G>A	uc001skb.2	-	23	2536	c.2430C>T	c.(2428-2430)TCC>TCT	p.S810S	SMARCC2_uc001skd.2_Silent_p.S841S|SMARCC2_uc001ska.2_Silent_p.S841S|SMARCC2_uc001skc.2_Silent_p.S840S|SMARCC2_uc010sqf.1_Silent_p.S730S	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	810	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
SMARCC2	6601	broad.mit.edu	37	12	56565655	56565655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56565655C>T	uc001skb.2	-	20	2006	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K	SMARCC2_uc001skd.2_Missense_Mutation_p.E665K|SMARCC2_uc001ska.2_Missense_Mutation_p.E665K|SMARCC2_uc001skc.2_Missense_Mutation_p.E664K|SMARCC2_uc010sqf.1_Missense_Mutation_p.E554K	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	634	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
SMARCC2	6601	broad.mit.edu	37	12	56581046	56581046	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56581046C>T	uc001skb.2	-	2	262	c.156G>A	c.(154-156)CTG>CTA	p.L52L	SMARCC2_uc001skd.2_Silent_p.L52L|SMARCC2_uc001ska.2_Silent_p.L52L|SMARCC2_uc001skc.2_Silent_p.L52L|SMARCC2_uc010sqf.1_5'UTR	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	52					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
SMARCC2	6601	broad.mit.edu	37	12	56583145	56583145	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56583145T>C	uc001skb.2	-	1	207	c.101A>G	c.(100-102)AAC>AGC	p.N34S	SMARCC2_uc001skd.2_Missense_Mutation_p.N34S|SMARCC2_uc001ska.2_Missense_Mutation_p.N34S|SMARCC2_uc001skc.2_Missense_Mutation_p.N34S|SMARCC2_uc010sqf.1_5'UTR	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	34					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)															---	---	---	---
SLC39A5	283375	broad.mit.edu	37	12	56628733	56628733	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56628733C>T	uc010sqj.1	+	6	854	c.597C>T	c.(595-597)GGC>GGT	p.G199G	SLC39A5_uc010sqi.1_Silent_p.G90G|SLC39A5_uc010sqk.1_Silent_p.G199G	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	199	Extracellular (By similarity).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
PAN2	9924	broad.mit.edu	37	12	56713165	56713165	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56713165C>T	uc001skx.2	-	23	3582	c.3209G>A	c.(3208-3210)CGT>CAT	p.R1070H	PAN2_uc001skw.2_Missense_Mutation_p.R218H|PAN2_uc001skz.2_Missense_Mutation_p.R1069H|PAN2_uc001sky.2_Missense_Mutation_p.R1066H	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1070	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6																		---	---	---	---
PAN2	9924	broad.mit.edu	37	12	56717655	56717655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56717655C>T	uc001skx.2	-	14	2493	c.2120G>A	c.(2119-2121)CGA>CAA	p.R707Q	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.R706Q|PAN2_uc001sky.2_Missense_Mutation_p.R703Q	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	707					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6																		---	---	---	---
BAZ2A	11176	broad.mit.edu	37	12	57005600	57005600	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57005600G>A	uc001slq.1	-	6	1766	c.1572C>T	c.(1570-1572)GAC>GAT	p.D524D	BAZ2A_uc001slp.1_Silent_p.D522D|BAZ2A_uc009zow.1_Silent_p.D492D	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	524					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0																		---	---	---	---
PTGES3	10728	broad.mit.edu	37	12	57060033	57060033	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57060033A>G	uc001slu.3	-	6	688	c.393T>C	c.(391-393)GGT>GGC	p.G131G	PTGES3_uc001slw.3_RNA|PTGES3_uc010sqs.1_Silent_p.G98G|PTGES3_uc001slv.3_Silent_p.G101G|PTGES3_uc010sqt.1_Intron|PTGES3_uc009zox.2_RNA	NM_006601	NP_006592	Q15185	TEBP_HUMAN	prostaglandin-E synthase 3	131	Asp/Glu-rich.				chaperone cofactor-dependent protein refolding|hormone biosynthetic process|prostaglandin biosynthetic process|signal transduction|telomere maintenance	cytosol|telomerase holoenzyme complex	prostaglandin-E synthase activity|telomerase activity|unfolded protein binding				0																		---	---	---	---
NACA	4666	broad.mit.edu	37	12	57111810	57111810	+	Intron	SNP	T	A	A	rs2926745		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57111810T>A	uc001slz.2	-						NACA_uc001sly.2_Intron|NACA_uc009zoy.1_Silent_p.P1168P|NACA_uc001smc.2_Intron|NACA_uc001sma.2_Intron|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
PRIM1	5557	broad.mit.edu	37	12	57135217	57135217	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57135217A>G	uc001smd.2	-	9	1046	c.982_splice	c.e9+1	p.G328_splice		NM_000946	NP_000937			DNA primase polypeptide 1						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding				0																		---	---	---	---
GPR182	11318	broad.mit.edu	37	12	57389660	57389660	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57389660A>G	uc001smk.2	+	2	761	c.667A>G	c.(667-669)ACC>GCC	p.T223A	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	223	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1																		---	---	---	---
ZBTB39	9880	broad.mit.edu	37	12	57397714	57397714	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57397714A>G	uc001sml.1	-	2	1074	c.988T>C	c.(988-990)TTG>CTG	p.L330L	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1																		---	---	---	---
STAT6	6778	broad.mit.edu	37	12	57499295	57499295	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57499295C>T	uc009zpe.2	-	8	1019	c.768G>A	c.(766-768)TCG>TCA	p.S256S	STAT6_uc009zpf.2_Silent_p.S256S|STAT6_uc001sna.2_Silent_p.S256S|STAT6_uc010srb.1_Silent_p.S146S|STAT6_uc010src.1_Silent_p.S146S|STAT6_uc010srd.1_Silent_p.S146S|STAT6_uc009zpg.2_Silent_p.S305S	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	256					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
LRP1	4035	broad.mit.edu	37	12	57532311	57532311	+	Missense_Mutation	SNP	G	A	A	rs146149784	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57532311G>A	uc001snd.2	+	2	603	c.137G>A	c.(136-138)CGG>CAG	p.R46Q	LRP1_uc010sre.1_Missense_Mutation_p.R46Q|LRP1_uc001snb.2_Missense_Mutation_p.R46Q|LRP1_uc001snc.1_Missense_Mutation_p.R46Q	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	46	LDL-receptor class A 1.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)													---	---	---	---
INHBC	3626	broad.mit.edu	37	12	57843705	57843705	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57843705C>T	uc001snv.1	+	2	1086	c.959C>T	c.(958-960)ACG>ATG	p.T320M		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	320					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0																		---	---	---	---
DDIT3	1649	broad.mit.edu	37	12	57910686	57910686	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57910686T>C	uc001soi.2	-	4	596	c.416A>G	c.(415-417)GAA>GGA	p.E139G	MARS_uc001sof.1_Intron|DDIT3_uc009zps.2_Missense_Mutation_p.E162G|DDIT3_uc009zpt.2_Missense_Mutation_p.E162G	NM_004083	NP_004074	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	139	Leucine-zipper.				cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of DNA-dependent transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding		FUS/DDIT3(623)|EWSR1/DDIT3(43)	soft_tissue(666)|large_intestine(1)|central_nervous_system(1)|lung(1)|skin(1)|ovary(1)	671								T	FUS	liposarcoma								---	---	---	---
DDIT3	1649	broad.mit.edu	37	12	57911081	57911081	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57911081T>C	uc001soi.2	-	3	289	c.109A>G	c.(109-111)ACC>GCC	p.T37A	MARS_uc001sof.1_RNA|DDIT3_uc009zps.2_Missense_Mutation_p.T60A|DDIT3_uc009zpt.2_Missense_Mutation_p.T60A	NM_004083	NP_004074	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	37					cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of DNA-dependent transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding		FUS/DDIT3(623)|EWSR1/DDIT3(43)	soft_tissue(666)|large_intestine(1)|central_nervous_system(1)|lung(1)|skin(1)|ovary(1)	671								T	FUS	liposarcoma								---	---	---	---
KIF5A	3798	broad.mit.edu	37	12	57963058	57963058	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57963058G>A	uc001sor.1	+	10	1047	c.839G>A	c.(838-840)CGT>CAT	p.R280H	KIF5A_uc010srr.1_Missense_Mutation_p.R191H	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	280	Kinesin-motor.|Microtubule-binding.		R -> H (in SPG10; complicated form).|R -> L (in SPG10; pure form).|R -> C (in SPG10).	R->S: Strongly reduces microtubule affinity; slightly reduces gliding velocity.	blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3																		---	---	---	---
PIP4K2C	79837	broad.mit.edu	37	12	57994872	57994872	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57994872C>A	uc001sou.2	+						PIP4K2C_uc001sot.2_Intron|PIP4K2C_uc010srs.1_Intron|PIP4K2C_uc010srt.1_Intron	NM_001146258	NP_001139730			phosphatidylinositol-5-phosphate 4-kinase, type							cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)																	---	---	---	---
DTX3	196403	broad.mit.edu	37	12	58001403	58001403	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58001403A>G	uc001sow.1	+						DTX3_uc001sox.1_Intron|DTX3_uc001soy.1_Intron|GEFT_uc009zpy.2_5'Flank|GEFT_uc001soz.1_5'Flank	NM_178502	NP_848597			deltex homolog 3						Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)																	---	---	---	---
AGAP2	116986	broad.mit.edu	37	12	58124631	58124631	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58124631C>T	uc001spq.2	-	11	2251	c.2251G>A	c.(2251-2253)GCC>ACC	p.A751T	AGAP2_uc001spp.2_Missense_Mutation_p.A751T|AGAP2_uc001spr.2_Missense_Mutation_p.A415T	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	751	PH.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5																		---	---	---	---
AVIL	10677	broad.mit.edu	37	12	58193644	58193644	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58193644A>G	uc001sqj.1	-	18	2309	c.2280T>C	c.(2278-2280)CCT>CCC	p.P760P	AVIL_uc009zqe.1_Silent_p.P753P	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	760	Headpiece (By similarity).|HP.				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)																	---	---	---	---
XRCC6BP1	91419	broad.mit.edu	37	12	58350647	58350647	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58350647C>T	uc001sqp.2	+	6	755	c.715C>T	c.(715-717)CGT>TGT	p.R239C		NM_033276	NP_150592	Q9Y6H3	ATP23_HUMAN	XRCC6 binding protein 1	239					double-strand break repair via nonhomologous end joining	DNA-dependent protein kinase-DNA ligase 4 complex	DNA-dependent protein kinase activity|metal ion binding|metalloendopeptidase activity			ovary(1)	1																		---	---	---	---
USP15	9958	broad.mit.edu	37	12	62777633	62777633	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:62777633C>T	uc001src.1	+	10	1111	c.1102C>T	c.(1102-1104)CGT>TGT	p.R368C	USP15_uc001srb.1_Missense_Mutation_p.R339C	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	368					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)														---	---	---	---
MON2	23041	broad.mit.edu	37	12	62949836	62949836	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:62949836T>C	uc001sre.2	+	25	3664	c.3273T>C	c.(3271-3273)ATT>ATC	p.I1091I	MON2_uc009zqj.2_Silent_p.I1091I|MON2_uc010ssl.1_Silent_p.I1019I|MON2_uc010ssm.1_Silent_p.I1068I|MON2_uc010ssn.1_Silent_p.I1091I|MON2_uc001srf.2_Silent_p.I854I	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1092					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)														---	---	---	---
AVPR1A	552	broad.mit.edu	37	12	63544060	63544060	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:63544060T>C	uc001sro.1	-	1	2531	c.557A>G	c.(556-558)TAC>TGC	p.Y186C		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	186	Helical; Name=4; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)													---	---	---	---
DPY19L2	283417	broad.mit.edu	37	12	64061918	64061918	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64061918G>A	uc001srp.1	-	1	437	c.256C>T	c.(256-258)CGT>TGT	p.R86C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	86					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)														---	---	---	---
HELB	92797	broad.mit.edu	37	12	66704385	66704385	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66704385T>C	uc001sti.2	+	4	1705	c.1677T>C	c.(1675-1677)TGT>TGC	p.C559C	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	559					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)														---	---	---	---
CAND1	55832	broad.mit.edu	37	12	67691600	67691600	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:67691600A>G	uc001stn.2	+	6	1258	c.821A>G	c.(820-822)TAC>TGC	p.Y274C	CAND1_uc001sto.2_5'Flank	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	274	HEAT 7.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)														---	---	---	---
CAND1	55832	broad.mit.edu	37	12	67692747	67692747	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:67692747A>G	uc001stn.2	+	7	1309	c.872A>G	c.(871-873)TAT>TGT	p.Y291C	CAND1_uc001sto.2_Translation_Start_Site	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	291	HEAT 8.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)														---	---	---	---
DYRK2	8445	broad.mit.edu	37	12	68051408	68051408	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68051408G>A	uc001str.3	+	3	1123	c.721G>A	c.(721-723)GAT>AAT	p.D241N	DYRK2_uc001sts.3_Missense_Mutation_p.D168N	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	241	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)														---	---	---	---
DYRK2	8445	broad.mit.edu	37	12	68052075	68052075	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68052075G>A	uc001str.3	+	3	1790	c.1388G>A	c.(1387-1389)CGT>CAT	p.R463H	DYRK2_uc001sts.3_Missense_Mutation_p.R390H	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	463	Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)														---	---	---	---
IL26	55801	broad.mit.edu	37	12	68619014	68619014	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68619014A>G	uc001stx.1	-	3	313	c.278T>C	c.(277-279)GTT>GCT	p.V93A		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	93					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)														---	---	---	---
MDM1	56890	broad.mit.edu	37	12	68720795	68720795	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:68720795G>A	uc001stz.2	-	3	276	c.140C>T	c.(139-141)ACG>ATG	p.T47M	MDM1_uc010stc.1_Missense_Mutation_p.T47M|MDM1_uc009zqv.1_Intron|MDM1_uc001sua.3_Missense_Mutation_p.T47M|MDM1_uc010std.1_3'UTR	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	47						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)														---	---	---	---
MDM2	4193	broad.mit.edu	37	12	69233299	69233299	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69233299T>C	uc001sui.2	+	11	1451	c.1164T>C	c.(1162-1164)ATT>ATC	p.I388I	MDM2_uc009zri.2_Silent_p.I343I|MDM2_uc009zqx.2_Silent_p.I333I|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Silent_p.I207I|MDM2_uc009zqz.2_Silent_p.I335I|MDM2_uc009zra.2_Silent_p.I186I|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_Silent_p.I72I|MDM2_uc009zrc.2_Silent_p.I72I|MDM2_uc009zre.2_Silent_p.I129I|MDM2_uc009zrf.2_Silent_p.I72I|MDM2_uc001suo.2_Silent_p.I182I|MDM2_uc009zrg.2_Silent_p.I104I|MDM2_uc009zrh.2_Silent_p.I156I	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	382	Necessary for interaction with USP2.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)					A		sarcoma|glioma|colorectal|other								---	---	---	---
BEST3	144453	broad.mit.edu	37	12	70070687	70070687	+	Intron	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70070687A>T	uc001svg.2	-						BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Intron|BEST3_uc001svh.2_Intron	NM_032735	NP_116124			vitelliform macular dystrophy 2-like 3 isoform							chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)															---	---	---	---
PTPRR	5801	broad.mit.edu	37	12	71056272	71056272	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:71056272T>C	uc001swi.1	-						PTPRR_uc001swf.1_Intron|PTPRR_uc001swg.1_Intron|PTPRR_uc001swh.1_Intron|PTPRR_uc009zrs.2_Intron|PTPRR_uc010stq.1_Intron|PTPRR_uc010str.1_Intron	NM_002849	NP_002840			protein tyrosine phosphatase, receptor type, R						in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)														---	---	---	---
LGR5	8549	broad.mit.edu	37	12	71976241	71976241	+	Missense_Mutation	SNP	C	T	T	rs145133989		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:71976241C>T	uc001swl.2	+	17	1606	c.1558C>T	c.(1558-1560)CGT>TGT	p.R520C	LGR5_uc001swm.2_Missense_Mutation_p.R496C|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	520	Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9																		---	---	---	---
ZFC3H1	196441	broad.mit.edu	37	12	72008422	72008422	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72008422T>A	uc001swo.2	-	30	5778	c.5419A>T	c.(5419-5421)AAA>TAA	p.K1807*		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1807	HAT 5.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
CAPS2	84698	broad.mit.edu	37	12	75685541	75685541	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75685541A>G	uc001sxk.3	-	14	1477	c.1280T>C	c.(1279-1281)GTC>GCC	p.V427A	CAPS2_uc001sxm.3_Missense_Mutation_p.V195A|CAPS2_uc009zsa.2_Missense_Mutation_p.V17A|CAPS2_uc001sxi.3_Missense_Mutation_p.V163A|CAPS2_uc001sxj.3_Missense_Mutation_p.V338A|CAPS2_uc001sxl.3_Missense_Mutation_p.V408A	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	427							calcium ion binding			ovary(2)	2																		---	---	---	---
E2F7	144455	broad.mit.edu	37	12	77440086	77440086	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77440086A>G	uc001sym.3	-	5	797	c.561T>C	c.(559-561)TAT>TAC	p.Y187Y	E2F7_uc001syn.2_Silent_p.Y187Y	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	187	Potential.				cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3																		---	---	---	---
E2F7	144455	broad.mit.edu	37	12	77449892	77449892	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:77449892G>A	uc001sym.3	-	3	348	c.112C>T	c.(112-114)CGA>TGA	p.R38*	E2F7_uc001syn.2_Nonsense_Mutation_p.R38*	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	38					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3																		---	---	---	---
NAV3	89795	broad.mit.edu	37	12	78562562	78562562	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:78562562A>G	uc001syp.2	+	24	5070	c.4897A>G	c.(4897-4899)ACC>GCC	p.T1633A	NAV3_uc001syo.2_Missense_Mutation_p.T1633A|NAV3_uc010sub.1_Missense_Mutation_p.T1119A|NAV3_uc009zsf.2_Missense_Mutation_p.T464A	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1633	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17															HNSCC(70;0.22)			---	---	---	---
Unknown	0	broad.mit.edu	37	12	80699432	80699432	+	IGR	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80699432T>A								PPP1R12A (370197 upstream) : PTPRQ (138694 downstream)																																			---	---	---	---
LIN7A	8825	broad.mit.edu	37	12	81239535	81239535	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81239535C>T	uc001szj.1	-	4	650	c.457G>A	c.(457-459)GAC>AAC	p.D153N	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	153	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2																		---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81675044	81675044	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81675044A>G	uc001szo.1	-	27	3365	c.3204T>C	c.(3202-3204)AGT>AGC	p.S1068S	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	967										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81688654	81688654	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81688654A>G	uc001szo.1	-	24	3046	c.2885T>C	c.(2884-2886)GTT>GCT	p.V962A	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	888										ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
TMTC2	160335	broad.mit.edu	37	12	83290084	83290084	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:83290084T>C	uc001szt.2	+	3	1574	c.1142T>C	c.(1141-1143)GTA>GCA	p.V381A	TMTC2_uc001szr.1_Missense_Mutation_p.V381A|TMTC2_uc001szs.1_Missense_Mutation_p.V381A|TMTC2_uc010suk.1_Missense_Mutation_p.V136A	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	381						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2																		---	---	---	---
SLC6A15	55117	broad.mit.edu	37	12	85279318	85279318	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85279318T>C	uc001szv.2	-	4	963	c.470A>G	c.(469-471)TAC>TGC	p.Y157C	SLC6A15_uc010sul.1_Missense_Mutation_p.Y50C|SLC6A15_uc001szy.2_Missense_Mutation_p.Y157C	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	157	Helical; Name=3; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3																		---	---	---	---
LRRIQ1	84125	broad.mit.edu	37	12	85439837	85439837	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85439837A>G	uc001tac.2	+	5	487	c.376A>G	c.(376-378)AAA>GAA	p.K126E	LRRIQ1_uc001tab.1_Missense_Mutation_p.K126E|LRRIQ1_uc001taa.1_Missense_Mutation_p.K126E|LRRIQ1_uc001tad.2_Missense_Mutation_p.K34E	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	126										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)														---	---	---	---
ALX1	8092	broad.mit.edu	37	12	85677642	85677642	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:85677642G>T	uc001tae.3	+	2	523	c.519G>T	c.(517-519)GAG>GAT	p.E173D		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	173	Homeobox.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)														---	---	---	---
C12orf29	91298	broad.mit.edu	37	12	88436611	88436611	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88436611A>G	uc001tao.2	+	3	376	c.218A>G	c.(217-219)TAC>TGC	p.Y73C	C12orf29_uc001tap.2_RNA|C12orf29_uc009zsk.2_RNA	NM_001009894	NP_001009894	Q8N999	CL029_HUMAN	hypothetical protein LOC91298	73											0																		---	---	---	---
KITLG	4254	broad.mit.edu	37	12	88939540	88939540	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88939540C>A	uc001tav.2	-	2	301	c.118G>T	c.(118-120)GTC>TTC	p.V40F	KITLG_uc001taw.2_Missense_Mutation_p.V40F	NM_000899	NP_000890	P21583	SCF_HUMAN	KIT ligand isoform b precursor	40	Extracellular (Potential).				cell adhesion|cell proliferation|hemopoiesis|male gonad development|positive regulation of DNA replication|signal transduction	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	growth factor activity|identical protein binding|stem cell factor receptor binding			ovary(1)	1														Testicular_Cancer_Familial_Clustering_of				---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94654559	94654559	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94654559C>T	uc001tdc.2	+	20	3642	c.3393C>T	c.(3391-3393)TCC>TCT	p.S1131S	PLXNC1_uc010sut.1_Silent_p.S178S|PLXNC1_uc009zsv.2_5'Flank	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1131	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
FGD6	55785	broad.mit.edu	37	12	95488366	95488366	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95488366A>G	uc001tdp.3	-	15	3824	c.3600_splice	c.e15+1	p.E1200_splice	FGD6_uc009zsx.2_Splice_Site_p.E333_splice|FGD6_uc001tdq.1_Splice_Site_p.E236_splice	NM_018351	NP_060821			FYVE, RhoGEF and PH domain containing 6						actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3																		---	---	---	---
FGD6	55785	broad.mit.edu	37	12	95546740	95546740	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95546740A>G	uc001tdp.3	-	4	2840	c.2616T>C	c.(2614-2616)GTT>GTC	p.V872V	FGD6_uc009zsx.2_Silent_p.V5V	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	872	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3																		---	---	---	---
METAP2	10988	broad.mit.edu	37	12	95879760	95879760	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95879760A>G	uc001tec.2	+						METAP2_uc010suv.1_Intron|METAP2_uc009ztd.2_Intron|METAP2_uc001ted.2_Intron|METAP2_uc001tef.2_Intron|METAP2_uc001tee.2_Intron	NM_006838	NP_006829			methionyl aminopeptidase 2						N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0					L-Methionine(DB00134)													---	---	---	---
USP44	84101	broad.mit.edu	37	12	95927368	95927368	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:95927368G>A	uc001teg.2	-	2	809	c.665C>T	c.(664-666)TCG>TTG	p.S222L	USP44_uc001teh.2_Missense_Mutation_p.S222L|USP44_uc009zte.2_Missense_Mutation_p.S219L	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	222					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
CCDC38	120935	broad.mit.edu	37	12	96263270	96263270	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96263270T>C	uc001tek.1	-	15	1800	c.1566A>G	c.(1564-1566)CAA>CAG	p.Q522Q		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	522	Potential.									skin(1)	1																		---	---	---	---
LTA4H	4048	broad.mit.edu	37	12	96407035	96407035	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:96407035A>G	uc001ten.1	-	14	1378	c.1310T>C	c.(1309-1311)GTT>GCT	p.V437A	LTA4H_uc010suy.1_Missense_Mutation_p.V399A|LTA4H_uc010suz.1_Missense_Mutation_p.V399A|LTA4H_uc010sva.1_RNA|LTA4H_uc009ztj.2_RNA	NM_000895	NP_000886	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	437					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)	1																		---	---	---	---
SLC25A3	5250	broad.mit.edu	37	12	98989556	98989556	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98989556G>A	uc001tfo.2	+						SLC25A3_uc001tfm.2_Missense_Mutation_p.G70D|SLC25A3_uc001tfn.2_Missense_Mutation_p.G70D|SLC25A3_uc001tfp.2_Missense_Mutation_p.G70D|SLC25A3_uc001tfq.2_Intron|SLC25A3_uc001tfr.2_Intron|SLC25A3_uc001tfs.2_Missense_Mutation_p.G27D|SLC25A3_uc009ztn.2_Missense_Mutation_p.G70D|SLC25A3_uc001tft.2_Missense_Mutation_p.G70D	NM_005888	NP_005879			solute carrier family 25 member 3 isoform a						generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)														---	---	---	---
FAM71C	196472	broad.mit.edu	37	12	100042499	100042499	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100042499A>G	uc001tgn.2	+	1	969	c.547A>G	c.(547-549)ACC>GCC	p.T183A	ANKS1B_uc001tge.1_Intron|ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_153364	NP_699195	Q8NEG0	FA71C_HUMAN	hypothetical protein LOC196472	183											0				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)														---	---	---	---
SLC17A8	246213	broad.mit.edu	37	12	100784773	100784773	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100784773T>C	uc010svi.1	+						SLC17A8_uc009ztx.2_Intron	NM_139319	NP_647480			solute carrier family 17 (sodium-dependent						neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3																		---	---	---	---
NR1H4	9971	broad.mit.edu	37	12	100930827	100930827	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100930827T>C	uc001tht.1	+	6	989	c.961_splice	c.e6+2	p.G321_splice	NR1H4_uc001thp.1_Splice_Site_p.G307_splice|NR1H4_uc001thq.1_Splice_Site_p.G311_splice|NR1H4_uc010svj.1_Splice_Site|NR1H4_uc001thr.1_Splice_Site_p.G311_splice|NR1H4_uc010svk.1_Splice_Site_p.G260_splice|NR1H4_uc001ths.1_Splice_Site_p.G317_splice	NM_005123	NP_005114			nuclear receptor subfamily 1, group H, member 4						bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
ANO4	121601	broad.mit.edu	37	12	101336279	101336279	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101336279A>G	uc010svm.1	+	5	994	c.422A>G	c.(421-423)AAC>AGC	p.N141S	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.N106S|ANO4_uc001thx.2_Missense_Mutation_p.N141S	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	141	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6															HNSCC(74;0.22)			---	---	---	---
ANO4	121601	broad.mit.edu	37	12	101381332	101381332	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101381332A>G	uc010svm.1	+	8	1190	c.618A>G	c.(616-618)ATA>ATG	p.I206M	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.I171M|ANO4_uc001thx.2_Missense_Mutation_p.I206M	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	206	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6															HNSCC(74;0.22)	OREG0022059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GNPTAB	79158	broad.mit.edu	37	12	102158613	102158613	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102158613T>C	uc001tit.2	-	13	2261	c.2082A>G	c.(2080-2082)AAA>AAG	p.K694K		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	694					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2																		---	---	---	---
PAH	5053	broad.mit.edu	37	12	103306669	103306669	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:103306669C>A	uc001tjq.1	-	3	540	c.68G>T	c.(67-69)AGC>ATC	p.S23I	PAH_uc010swc.1_Missense_Mutation_p.S23I	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	23					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)													---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104067847	104067847	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104067847A>G	uc001tjw.2	+	23	2720	c.2534A>G	c.(2533-2535)TAC>TGC	p.Y845C		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	845	Extracellular (Potential).|EGF-like 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
HSP90B1	7184	broad.mit.edu	37	12	104340627	104340627	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104340627C>T	uc001tkb.1	+	16	2275	c.2170C>T	c.(2170-2172)CGG>TGG	p.R724W	HSP90B1_uc010swg.1_Missense_Mutation_p.R389W|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	724					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)													---	---	---	---
GLT8D2	83468	broad.mit.edu	37	12	104388210	104388210	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104388210A>G	uc001tkh.1	-	9	1076	c.670T>C	c.(670-672)TGC>CGC	p.C224R	GLT8D2_uc001tki.1_Missense_Mutation_p.C224R	NM_031302	NP_112592	Q9H1C3	GL8D2_HUMAN	glycosyltransferase 8 domain containing 2	224	Lumenal (Potential).					integral to membrane	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2																		---	---	---	---
APPL2	55198	broad.mit.edu	37	12	105622983	105622983	+	Missense_Mutation	SNP	C	T	T	rs143353224		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:105622983C>T	uc001tlf.1	-	2	291	c.73G>A	c.(73-75)GTG>ATG	p.V25M	APPL2_uc010swt.1_Translation_Start_Site|APPL2_uc001tlg.1_Translation_Start_Site|APPL2_uc010swu.1_Missense_Mutation_p.V25M|APPL2_uc009zuq.2_Translation_Start_Site	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	25	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
CKAP4	10970	broad.mit.edu	37	12	106633587	106633587	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:106633587C>T	uc001tlk.2	-	2	1108	c.1024G>A	c.(1024-1026)GCC>ACC	p.A342T		NM_006825	NP_006816	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	342	Potential.					ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction					0																		---	---	---	---
RIC8B	55188	broad.mit.edu	37	12	107208622	107208622	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107208622G>A	uc001tlx.2	+	3	406	c.281G>A	c.(280-282)CGA>CAA	p.R94Q	RIC8B_uc001tlw.2_Missense_Mutation_p.R94Q|RIC8B_uc001tly.2_Missense_Mutation_p.R54Q|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	94					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
CRY1	1407	broad.mit.edu	37	12	107386601	107386601	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107386601A>G	uc001tmi.3	-	12	2584	c.1725T>C	c.(1723-1725)AGT>AGC	p.S575S		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	575					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3																		---	---	---	---
SART3	9733	broad.mit.edu	37	12	108941702	108941702	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:108941702C>T	uc001tmz.1	-	3	740	c.505G>A	c.(505-507)GTG>ATG	p.V169M	SART3_uc009zux.1_Translation_Start_Site|SART3_uc010swx.1_Missense_Mutation_p.V169M|SART3_uc010swy.1_Missense_Mutation_p.V37M|SART3_uc010swz.1_Missense_Mutation_p.V169M|SART3_uc001tna.1_RNA	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	169	HAT 2.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1														Porokeratosis				---	---	---	---
USP30	84749	broad.mit.edu	37	12	109520724	109520724	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109520724A>G	uc010sxi.1	+	11	1129	c.1025A>G	c.(1024-1026)CAC>CGC	p.H342R	USP30_uc001tnu.3_Missense_Mutation_p.H311R|USP30_uc001tnw.3_Missense_Mutation_p.H59R	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	342	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1																		---	---	---	---
ACACB	32	broad.mit.edu	37	12	109685423	109685423	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109685423C>A	uc001tob.2	+	40	5703	c.5584C>A	c.(5584-5586)CTG>ATG	p.L1862M	ACACB_uc001toc.2_Missense_Mutation_p.L1862M|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.L528M	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1862	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)													---	---	---	---
KCTD10	83892	broad.mit.edu	37	12	109898554	109898554	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109898554G>C	uc001toi.1	-	3	362	c.274C>G	c.(274-276)CGA>GGA	p.R92G	KCTD10_uc001toh.1_5'Flank|KCTD10_uc009zvi.1_Missense_Mutation_p.R89G|KCTD10_uc001toj.1_Missense_Mutation_p.R100G|KCTD10_uc001tok.1_Intron	NM_031954	NP_114160	Q9H3F6	BACD3_HUMAN	potassium channel tetramerisation domain	92	BTB.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity				0																		---	---	---	---
TRPV4	59341	broad.mit.edu	37	12	110226519	110226519	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110226519G>A	uc001tpj.1	-	12	1989	c.1894C>T	c.(1894-1896)CTG>TTG	p.L632L	TRPV4_uc001tpg.1_Silent_p.L598L|TRPV4_uc001tph.1_Silent_p.L585L|TRPV4_uc001tpi.1_Silent_p.L525L|TRPV4_uc001tpk.1_Silent_p.L632L|TRPV4_uc001tpl.1_Silent_p.L572L	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	632	Helical; (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
PPTC7	160760	broad.mit.edu	37	12	110989605	110989605	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110989605A>G	uc001trh.1	-	2	620	c.392T>C	c.(391-393)GTC>GCC	p.V131A		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C	131	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity				0																		---	---	---	---
TCTN1	79600	broad.mit.edu	37	12	111057695	111057695	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111057695G>A	uc009zvs.2	+	2	383	c.275G>A	c.(274-276)TGC>TAC	p.C92Y	TCTN1_uc010syb.1_Missense_Mutation_p.C92Y|TCTN1_uc009zvr.1_RNA|TCTN1_uc001trl.2_RNA|TCTN1_uc001trm.2_Missense_Mutation_p.C32Y|TCTN1_uc010syc.1_RNA|TCTN1_uc001tro.2_RNA|TCTN1_uc001trp.3_Missense_Mutation_p.C92Y|TCTN1_uc001trn.3_Missense_Mutation_p.C92Y|TCTN1_uc001tri.2_Missense_Mutation_p.C36Y|TCTN1_uc001trj.1_Missense_Mutation_p.C36Y|TCTN1_uc001trk.3_RNA	NM_001082537	NP_001076006	Q2MV58	TECT1_HUMAN	tectonic family member 1 isoform 2	92	Cys-rich.				multicellular organismal development	extracellular region					0																		---	---	---	---
CCDC63	160762	broad.mit.edu	37	12	111317711	111317711	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111317711T>C	uc001trv.1	+	6	686	c.491T>C	c.(490-492)GTC>GCC	p.V164A	CCDC63_uc009zvt.1_Intron|CCDC63_uc010sye.1_Missense_Mutation_p.V124A|CCDC63_uc001trw.1_Missense_Mutation_p.V79A	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	164	Potential.									skin(6)|ovary(1)|pancreas(1)	8																		---	---	---	---
MYL2	4633	broad.mit.edu	37	12	111356998	111356998	+	Splice_Site	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111356998C>A	uc001try.3	-	2	75	c.4_splice	c.e2-1	p.A2_splice	MYL2_uc001trx.3_Translation_Start_Site	NM_000432	NP_000423			slow cardiac myosin regulatory light chain 2						cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1																		---	---	---	---
ACAD10	80724	broad.mit.edu	37	12	112193508	112193508	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112193508G>A	uc001tsq.2	+	20	3198	c.2998G>A	c.(2998-3000)GCC>ACC	p.A1000T	ACAD10_uc009zvx.2_Missense_Mutation_p.A1031T|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	1000							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2																		---	---	---	---
MAPKAPK5	8550	broad.mit.edu	37	12	112305379	112305379	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112305379C>T	uc001tta.2	+	4	449	c.190C>T	c.(190-192)CGT>TGT	p.R64C	MAPKAPK5_uc001tsz.2_Missense_Mutation_p.R64C|MAPKAPK5_uc001ttb.2_Translation_Start_Site	NM_139078	NP_620777	Q8IW41	MAPK5_HUMAN	MAP kinase-activated protein kinase 5 isoform 2	64	Protein kinase.				signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)	3																		---	---	---	---
ERP29	10961	broad.mit.edu	37	12	112460247	112460247	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112460247G>A	uc001ttk.1	+	3	695	c.577G>A	c.(577-579)GAG>AAG	p.E193K	ERP29_uc001ttl.1_3'UTR	NM_006817	NP_006808	P30040	ERP29_HUMAN	endoplasmic reticulum protein 29 isoform 1	193					intracellular protein transport|protein folding|protein secretion	endoplasmic reticulum lumen|melanosome	protein disulfide isomerase activity				0																		---	---	---	---
NAA25	80018	broad.mit.edu	37	12	112525484	112525484	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112525484T>C	uc001ttm.2	-						NAA25_uc001ttn.3_Intron|NAA25_uc009zvz.1_Intron|NAA25_uc009zwa.1_Intron	NM_024953	NP_079229			mitochondrial distribution and morphology 20							cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
RPH3A	22895	broad.mit.edu	37	12	113306354	113306354	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113306354A>G	uc010syl.1	+	8	926	c.564A>G	c.(562-564)GAA>GAG	p.E188E	RPH3A_uc001ttz.2_Silent_p.E188E|RPH3A_uc001tty.2_Silent_p.E184E|RPH3A_uc009zwe.1_Silent_p.E184E|RPH3A_uc010sym.1_Silent_p.E139E|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	188	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)														---	---	---	---
OAS1	4938	broad.mit.edu	37	12	113354471	113354471	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113354471A>G	uc001tud.2	+	4	918	c.812A>G	c.(811-813)TAC>TGC	p.Y271C	OAS1_uc010syn.1_Missense_Mutation_p.Y270C|OAS1_uc010syo.1_3'UTR|OAS1_uc001tub.2_Missense_Mutation_p.Y271C|OAS1_uc001tuc.2_Missense_Mutation_p.Y271C|OAS1_uc009zwf.2_Missense_Mutation_p.Y270C	NM_016816	NP_058132	P00973	OAS1_HUMAN	2',5'-oligoadenylate synthetase 1 isoform 1	271					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(2)	2																		---	---	---	---
DTX1	1840	broad.mit.edu	37	12	113532900	113532900	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113532900T>C	uc001tuk.1	+	7	1776	c.1440T>C	c.(1438-1440)GGT>GGC	p.G480G		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	480					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
DDX54	79039	broad.mit.edu	37	12	113612693	113612693	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113612693T>C	uc001tup.2	-	9	951	c.923A>G	c.(922-924)AAC>AGC	p.N308S	DDX54_uc001tuq.3_Missense_Mutation_p.N308S	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	308					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3																OREG0022139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TPCN1	53373	broad.mit.edu	37	12	113723763	113723763	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113723763A>G	uc001tuw.2	+	18	1820	c.1523A>G	c.(1522-1524)AAC>AGC	p.N508S	TPCN1_uc001tux.2_Missense_Mutation_p.N580S|TPCN1_uc010syt.1_Missense_Mutation_p.N440S	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	508	Helical; Name=S3 of repeat II; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3																		---	---	---	---
RBM19	9904	broad.mit.edu	37	12	114397151	114397151	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:114397151G>A	uc009zwi.2	-	5	581	c.437C>T	c.(436-438)GCA>GTA	p.A146V	RBM19_uc001tvn.3_Missense_Mutation_p.A146V|RBM19_uc001tvm.2_Missense_Mutation_p.A146V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	146					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)																	---	---	---	---
TBX5	6910	broad.mit.edu	37	12	114841604	114841604	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:114841604C>G	uc001tvo.2	-	2	595	c.100G>C	c.(100-102)GCC>CCC	p.A34P	TBX5_uc001tvp.2_Missense_Mutation_p.A34P|TBX5_uc001tvq.2_Intron|TBX5_uc010syv.1_Missense_Mutation_p.A34P	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	34				GFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFT QQ -> ALAGAHLWSLTQKTCLRFEPRARSGPPASPPGRPR SRLHPA (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)														---	---	---	---
TBX3	6926	broad.mit.edu	37	12	115117308	115117308	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:115117308A>G	uc001tvt.1	-	4	1828	c.864_splice	c.e4+1	p.K288_splice	TBX3_uc001tvu.1_Splice_Site_p.K268_splice	NM_016569	NP_057653			T-box 3 protein isoform 2						anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)														---	---	---	---
MED13L	23389	broad.mit.edu	37	12	116457117	116457117	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:116457117A>G	uc001tvw.2	-	7	976	c.921T>C	c.(919-921)GTT>GTC	p.V307V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	307					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)														---	---	---	---
NOS1	4842	broad.mit.edu	37	12	117723943	117723943	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:117723943C>T	uc001twm.1	-	6	1942	c.1256G>A	c.(1255-1257)CGC>CAC	p.R419H		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	419					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)													---	---	---	---
TAOK3	51347	broad.mit.edu	37	12	118590074	118590074	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118590074T>C	uc001twx.2	-	20	2788	c.2493A>G	c.(2491-2493)CTA>CTG	p.L831L	TAOK3_uc001twv.2_Silent_p.L371L|TAOK3_uc001tww.2_Silent_p.L661L|TAOK3_uc001twy.3_Silent_p.L831L	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	831	Potential.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
CIT	11113	broad.mit.edu	37	12	120142198	120142198	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120142198G>A	uc001txi.1	-	40	5201	c.5148C>T	c.(5146-5148)AAC>AAT	p.N1716N	CIT_uc001txh.1_Silent_p.N1235N|CIT_uc001txj.1_Silent_p.N1758N	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1716	CNH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)														---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120567101	120567101	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120567101C>T	uc001txo.2	-	57	7882	c.7869G>A	c.(7867-7869)CGG>CGA	p.R2623R		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2623	HEAT 24.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120575062	120575062	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120575062A>G	uc001txo.2	-	50	6738	c.6725T>C	c.(6724-6726)ATA>ACA	p.I2242T		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2242					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
GCN1L1	10985	broad.mit.edu	37	12	120593173	120593173	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120593173C>T	uc001txo.2	-	30	3515	c.3502G>A	c.(3502-3504)GTG>ATG	p.V1168M		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1168					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
RPLP0	6175	broad.mit.edu	37	12	120635190	120635190	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120635190T>C	uc001txp.2	-	7	964	c.727A>G	c.(727-729)AAC>GAC	p.N243D	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Missense_Mutation_p.N243D|RPLP0_uc001txr.2_Missense_Mutation_p.N181D	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	243					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
RNF34	80196	broad.mit.edu	37	12	121858092	121858092	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121858092C>T	uc001ual.1	+	4	795	c.681C>T	c.(679-681)GAC>GAT	p.D227D	RNF34_uc001uak.1_Silent_p.D228D|RNF34_uc001uam.1_Silent_p.D227D	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	227	Asp-rich.				apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)														---	---	---	---
ZCCHC8	55596	broad.mit.edu	37	12	122958303	122958303	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122958303G>A	uc001ucn.2	-	14	1996	c.1865C>T	c.(1864-1866)GCC>GTC	p.A622V	ZCCHC8_uc001ucl.2_Missense_Mutation_p.A233V|ZCCHC8_uc001ucm.2_Missense_Mutation_p.A384V|ZCCHC8_uc009zxp.2_Missense_Mutation_p.A384V|ZCCHC8_uc009zxq.2_Missense_Mutation_p.A384V	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	622						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)														---	---	---	---
RSRC2	65117	broad.mit.edu	37	12	123005956	123005956	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123005956G>A	uc001ucr.2	-	3	329	c.183C>T	c.(181-183)CAC>CAT	p.H61H	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_5'UTR|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.T6I|RSRC2_uc001ucu.2_Silent_p.H61H	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	61	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123060422	123060422	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123060422A>G	uc001ucv.2	+	29	2725	c.2562A>G	c.(2560-2562)GTA>GTG	p.V854V	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	854					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123099602	123099602	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123099602G>A	uc001ucv.2	+	56	6105	c.5942G>A	c.(5941-5943)GGA>GAA	p.G1981E	KNTC1_uc010taf.1_Missense_Mutation_p.G906E	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1981					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
SBNO1	55206	broad.mit.edu	37	12	123806165	123806165	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123806165T>C	uc010tap.1	-	16	2240	c.2240A>G	c.(2239-2241)TAT>TGT	p.Y747C	SBNO1_uc010tao.1_Missense_Mutation_p.Y746C|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.Y747C|SBNO1_uc001ueu.2_Missense_Mutation_p.Y746C|SBNO1_uc001uev.2_Missense_Mutation_p.Y745C|SBNO1_uc009zxy.1_Missense_Mutation_p.Y712C	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	747							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)														---	---	---	---
DDX55	57696	broad.mit.edu	37	12	124102328	124102328	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124102328G>A	uc001ufi.2	+	11	1097	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	DDX55_uc001ufh.2_Missense_Mutation_p.R211H|DDX55_uc001ufj.1_Missense_Mutation_p.R211H|DDX55_uc001ufk.2_Missense_Mutation_p.R211H|DDX55_uc001ufl.2_5'Flank	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	358	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124330240	124330240	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124330240G>A	uc001uft.3	+	30	5125	c.5100G>A	c.(5098-5100)GCG>GCA	p.A1700A		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1700	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124345724	124345724	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124345724A>G	uc001uft.3	+							NM_207437	NP_997320			dynein, axonemal, heavy chain 10						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124352477	124352477	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124352477G>A	uc001uft.3	+	42	7001	c.6976G>A	c.(6976-6978)GCG>ACG	p.A2326T		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2326					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
ZNF664	144348	broad.mit.edu	37	12	124496699	124496699	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124496699A>G	uc001ufz.2	+	6	1838	c.8A>G	c.(7-9)TAC>TGC	p.Y3C	ZNF664_uc001uga.2_Missense_Mutation_p.Y3C|ZNF664_uc001ugb.2_Missense_Mutation_p.Y3C	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	3	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)														---	---	---	---
DHX37	57647	broad.mit.edu	37	12	125432358	125432358	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:125432358G>T	uc001ugy.2	-	27	3563	c.3464C>A	c.(3463-3465)ACT>AAT	p.T1155N	DHX37_uc001ugz.1_3'UTR	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1155				YLLAEYCEWLPQAMHPDIEKAWPPTTVH -> CEFDQGQGV GVDRMGSLRQGLCALCTVSPGLAEGSGPTAAGQLFAT (in Ref. 2).			ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)														---	---	---	---
SLC15A4	121260	broad.mit.edu	37	12	129278857	129278857	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:129278857C>T	uc001uhu.2	-	8	1671	c.1618G>A	c.(1618-1620)GCT>ACT	p.A540T	SLC15A4_uc001uhv.2_RNA	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	solute carrier family 15, member 4	540	Helical; (Potential).				oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)														---	---	---	---
RIMBP2	23504	broad.mit.edu	37	12	130941158	130941158	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130941158G>A	uc001uil.2	-	4	354	c.190C>T	c.(190-192)CAC>TAC	p.H64Y	RIMBP2_uc001uim.2_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	64						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)														---	---	---	---
GPR133	283383	broad.mit.edu	37	12	131439178	131439178	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:131439178G>A	uc001uit.3	+	2	635	c.76G>A	c.(76-78)GTC>ATC	p.V26I	GPR133_uc010tbm.1_Missense_Mutation_p.V26I	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	26	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)														---	---	---	---
EP400	57634	broad.mit.edu	37	12	132512679	132512679	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132512679A>G	uc001ujn.2	+	26	5262	c.5227A>G	c.(5227-5229)AGC>GGC	p.S1743G	EP400_uc001ujl.2_Missense_Mutation_p.S1742G|EP400_uc001ujm.2_Missense_Mutation_p.S1662G	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1779					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)														---	---	---	---
EP400	57634	broad.mit.edu	37	12	132561083	132561083	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132561083T>C	uc001ujn.2	+	51	9079	c.9044T>C	c.(9043-9045)GTT>GCT	p.V3015A	EP400_uc001ujl.2_Missense_Mutation_p.V3014A|EP400_uc001ujm.2_Missense_Mutation_p.V2934A|EP400_uc001ujp.2_Missense_Mutation_p.V225A|EP400_uc010tbo.1_Silent_p.C81C	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	3051					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)														---	---	---	---
POLE	5426	broad.mit.edu	37	12	133241979	133241979	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133241979G>A	uc001uks.1	-	21	2421	c.2377C>T	c.(2377-2379)CGC>TGC	p.R793C	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R766C	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	793					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
POLE	5426	broad.mit.edu	37	12	133245254	133245254	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133245254G>A	uc001uks.1	-	18	2037	c.1993C>T	c.(1993-1995)CGG>TGG	p.R665W	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R638W	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	665					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
POLE	5426	broad.mit.edu	37	12	133256634	133256634	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133256634T>C	uc001uks.1	-	5	375	c.331_splice	c.e5-1	p.G111_splice	POLE_uc010tbq.1_Splice_Site|POLE_uc009zyu.1_Splice_Site_p.G84_splice	NM_006231	NP_006222			DNA-directed DNA polymerase epsilon						base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
ANKLE2	23141	broad.mit.edu	37	12	133310978	133310978	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133310978G>T	uc001ukx.2	-	10	1951	c.1884C>A	c.(1882-1884)ACC>ACA	p.T628T	ANKLE2_uc009zyw.1_5'UTR|ANKLE2_uc001uky.3_Silent_p.T566T	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	628						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)														---	---	---	---
GOLGA3	2802	broad.mit.edu	37	12	133354367	133354367	+	Missense_Mutation	SNP	C	T	T	rs141137343		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133354367C>T	uc001ukz.1	-	19	4166	c.3607G>A	c.(3607-3609)GGG>AGG	p.G1203R	GOLGA3_uc001ula.1_Missense_Mutation_p.G1203R	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1203	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)														---	---	---	---
ZNF605	100289635	broad.mit.edu	37	12	133502068	133502068	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133502068C>A	uc001ulh.2	-	5	2142	c.1817G>T	c.(1816-1818)AGG>ATG	p.R606M	ZNF605_uc001uli.2_Missense_Mutation_p.R637M|ZNF605_uc001ulj.2_Missense_Mutation_p.R606M	NM_183238	NP_899061	Q86T29	ZN605_HUMAN	zinc finger protein 605 isoform 1	606	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)														---	---	---	---
TPTE2	93492	broad.mit.edu	37	13	20056655	20056655	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20056655T>C	uc001umd.2	-	5	363	c.152A>G	c.(151-153)GAA>GGA	p.E51G	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Missense_Mutation_p.E51G|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	51						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)														---	---	---	---
TPTE2	93492	broad.mit.edu	37	13	20067054	20067054	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20067054A>C	uc001umd.2	-						TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_Intron	NM_199254	NP_954863			TPTE and PTEN homologous inositol lipid							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)														---	---	---	---
MPHOSPH8	54737	broad.mit.edu	37	13	20245347	20245347	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20245347A>G	uc001umh.2	+	13	2468	c.2459A>G	c.(2458-2460)GAC>GGC	p.D820G		NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	820					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)														---	---	---	---
PSPC1	55269	broad.mit.edu	37	13	20356666	20356666	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20356666A>G	uc001uml.2	-	1	418	c.232T>C	c.(232-234)TAC>CAC	p.Y78H	PSPC1_uc001umj.1_RNA|PSPC1_uc001umk.1_RNA	NM_001042414	NP_001035879	Q8WXF1	PSPC1_HUMAN	paraspeckle protein 1	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)														---	---	---	---
N6AMT2	221143	broad.mit.edu	37	13	21311923	21311923	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21311923T>C	uc001uno.1	-	3	247	c.166A>G	c.(166-168)AGT>GGT	p.S56G	N6AMT2_uc009zzr.1_Missense_Mutation_p.S56G|N6AMT2_uc001unp.2_Intron	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2	56							methyltransferase activity|nucleic acid binding				0		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)														---	---	---	---
LATS2	26524	broad.mit.edu	37	13	21562886	21562886	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21562886G>A	uc009zzs.2	-	4	1398	c.1033C>T	c.(1033-1035)CAG>TAG	p.Q345*	LATS2_uc001unr.3_Nonsense_Mutation_p.Q345*	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	345					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)														---	---	---	---
LATS2	26524	broad.mit.edu	37	13	21562970	21562970	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21562970G>A	uc009zzs.2	-	4	1314	c.949C>T	c.(949-951)CAC>TAC	p.H317Y	LATS2_uc001unr.3_Missense_Mutation_p.H317Y	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	317					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23932488	23932488	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23932488A>G	uc001uon.2	-	7	1179	c.590T>C	c.(589-591)GTC>GCC	p.V197A	SACS_uc001uoo.2_Missense_Mutation_p.V50A|SACS_uc001uop.1_5'Flank|SACS_uc001uoq.1_Missense_Mutation_p.V50A	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	197					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
ATP12A	479	broad.mit.edu	37	13	25268672	25268672	+	Missense_Mutation	SNP	C	T	T	rs145531717		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25268672C>T	uc001upp.2	+	11	1655	c.1468C>T	c.(1468-1470)CGC>TGC	p.R490C	ATP12A_uc010aaa.2_Missense_Mutation_p.R496C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	490	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)											OREG0022298	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RNF17	56163	broad.mit.edu	37	13	25338390	25338390	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25338390C>T	uc001upr.2	+	1	90	c.49C>T	c.(49-51)CGA>TGA	p.R17*	RNF17_uc010tdd.1_5'UTR|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Nonsense_Mutation_p.R17*|RNF17_uc001ups.2_5'UTR|RNF17_uc001upq.1_Nonsense_Mutation_p.R17*	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	17					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)														---	---	---	---
RNF17	56163	broad.mit.edu	37	13	25448299	25448299	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25448299A>G	uc001upr.2	+	33	4536	c.4495A>G	c.(4495-4497)AAG>GAG	p.K1499E	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.K1495E|RNF17_uc001ups.2_Missense_Mutation_p.K1438E|RNF17_uc010aac.2_Missense_Mutation_p.K691E|RNF17_uc010aad.2_Missense_Mutation_p.K509E	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1499	Tudor 4.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)														---	---	---	---
SHISA2	387914	broad.mit.edu	37	13	26621066	26621066	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:26621066T>C	uc001uqm.1	-	2	558	c.473A>G	c.(472-474)AAC>AGC	p.N158S		NM_001007538	NP_001007539	Q6UWI4	SHSA2_HUMAN	shisa homolog 2 precursor	158	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GPR12	2835	broad.mit.edu	37	13	27332961	27332961	+	Nonstop_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:27332961T>C	uc010aal.2	-	2	1226	c.1004A>G	c.(1003-1005)TAG>TGG	p.*335W	GPR12_uc010tdl.1_Nonstop_Mutation_p.*176W	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	335						integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)														---	---	---	---
MTIF3	219402	broad.mit.edu	37	13	28014141	28014141	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28014141C>A	uc001urh.2	-	1	1669	c.445G>T	c.(445-447)GCG>TCG	p.A149S	MTIF3_uc001uri.2_Missense_Mutation_p.A149S|MTIF3_uc001urj.2_Missense_Mutation_p.A149S|MTIF3_uc001urk.2_Missense_Mutation_p.A149S	NM_152912	NP_690876	Q9H2K0	IF3M_HUMAN	mitochondrial translational initiation factor 3	149					regulation of translational initiation|ribosome disassembly	mitochondrion	ribosomal small subunit binding|translation initiation factor activity			ovary(1)|skin(1)	2		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.108)|OV - Ovarian serous cystadenocarcinoma(117;0.157)														---	---	---	---
FLT3	2322	broad.mit.edu	37	13	28610120	28610120	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28610120T>C	uc001urw.2	-	11	1452	c.1370A>G	c.(1369-1371)TAC>TGC	p.Y457C	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.Y457C	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	457	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)			Mis|O		AML|ALL								---	---	---	---
FLT3	2322	broad.mit.edu	37	13	28611391	28611391	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28611391C>A	uc001urw.2	-	10	1322	c.1240G>T	c.(1240-1242)GGA>TGA	p.G414*	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Nonsense_Mutation_p.G414*	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	414	Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)			Mis|O		AML|ALL								---	---	---	---
PAN3	255967	broad.mit.edu	37	13	28841299	28841299	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28841299T>C	uc001urz.2	+	10	1211	c.1203T>C	c.(1201-1203)AAT>AAC	p.N401N	PAN3_uc010tdo.1_Silent_p.N547N|PAN3_uc001ury.2_Silent_p.N235N|PAN3_uc001urx.2_Silent_p.N347N	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	547	Protein kinase.|Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)														---	---	---	---
PAN3	255967	broad.mit.edu	37	13	28862168	28862168	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28862168T>C	uc001urz.2	+	17	2002	c.1994T>C	c.(1993-1995)TTG>TCG	p.L665S	PAN3_uc001ury.2_Missense_Mutation_p.L499S|PAN3_uc001urx.2_Missense_Mutation_p.L611S	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	811	Interaction with PAN2.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)														---	---	---	---
FLT1	2321	broad.mit.edu	37	13	28896941	28896941	+	Missense_Mutation	SNP	A	G	G	rs116741209	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:28896941A>G	uc001usb.3	-	21	3224	c.2939T>C	c.(2938-2940)GTT>GCT	p.V980A	FLT1_uc010aap.2_5'Flank|FLT1_uc010aaq.2_Missense_Mutation_p.V105A|FLT1_uc001usa.3_Missense_Mutation_p.V198A	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	980	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)													---	---	---	---
SLC46A3	283537	broad.mit.edu	37	13	29287455	29287455	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:29287455C>T	uc001usi.2	-	2	1392	c.422G>A	c.(421-423)TGT>TAT	p.C141Y	SLC46A3_uc001usg.2_Missense_Mutation_p.C66Y|SLC46A3_uc001usj.2_Missense_Mutation_p.C141Y|SLC46A3_uc001ush.2_Missense_Mutation_p.C141Y|SLC46A3_uc001usk.2_Missense_Mutation_p.C66Y	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	141	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)														---	---	---	---
USPL1	10208	broad.mit.edu	37	13	31232624	31232624	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31232624A>G	uc001utc.2	+	9	2842	c.2410A>G	c.(2410-2412)ATA>GTA	p.I804V	USPL1_uc001utd.2_Missense_Mutation_p.I475V|USPL1_uc001ute.1_Missense_Mutation_p.I475V	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	804					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)														---	---	---	---
HSPH1	10808	broad.mit.edu	37	13	31725327	31725327	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31725327A>T	uc001utj.2	-	7	1063	c.665T>A	c.(664-666)GTA>GAA	p.V222E	HSPH1_uc001utk.2_Missense_Mutation_p.V222E|HSPH1_uc010aaw.2_Missense_Mutation_p.V181E|HSPH1_uc001utl.2_Missense_Mutation_p.V224E|HSPH1_uc010tds.1_Missense_Mutation_p.V146E|HSPH1_uc010tdt.1_RNA	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	222					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)														---	---	---	---
RXFP2	122042	broad.mit.edu	37	13	32352645	32352645	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32352645A>G	uc001utt.2	+						RXFP2_uc010aba.2_Intron	NM_130806	NP_570718			relaxin/insulin-like family peptide receptor 2							integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)														---	---	---	---
RXFP2	122042	broad.mit.edu	37	13	32376343	32376343	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32376343T>A	uc001utt.2	+	18	2137	c.2066T>A	c.(2065-2067)ATC>AAC	p.I689N	RXFP2_uc010aba.2_Missense_Mutation_p.I648N	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	689	Helical; Name=7; (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)														---	---	---	---
FRY	10129	broad.mit.edu	37	13	32653054	32653054	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32653054C>T	uc001utx.2	+	2	650	c.154C>T	c.(154-156)CTA>TTA	p.L52L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)														---	---	---	---
BRCA2	675	broad.mit.edu	37	13	32913067	32913067	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32913067T>C	uc001uub.1	+	11	4802	c.4575T>C	c.(4573-4575)CAT>CAC	p.H1525H		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1525	BRCA2 4.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)				D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			---	---	---	---
BRCA2	675	broad.mit.edu	37	13	32913920	32913920	+	Missense_Mutation	SNP	G	A	A	rs80358766		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32913920G>A	uc001uub.1	+	11	5655	c.5428G>A	c.(5428-5430)GTT>ATT	p.V1810I		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1810					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)				D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			---	---	---	---
BRCA2	675	broad.mit.edu	37	13	32914557	32914557	+	Missense_Mutation	SNP	C	T	T	rs80358843		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:32914557C>T	uc001uub.1	+	11	6292	c.6065C>T	c.(6064-6066)TCA>TTA	p.S2022L		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2022					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)				D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			---	---	---	---
N4BP2L2	10443	broad.mit.edu	37	13	33012780	33012780	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33012780C>T	uc010abe.1	-						N4BP2L2_uc001uug.2_Intron|N4BP2L2_uc010abd.1_Intron|N4BP2L2_uc001uuh.2_Intron|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Intron	NM_033111	NP_149102			phosphonoformate immuno-associated protein 5												0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)														---	---	---	---
STARD13	90627	broad.mit.edu	37	13	33701537	33701537	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33701537G>A	uc001uuw.2	-	6	2021	c.1895C>T	c.(1894-1896)TCC>TTC	p.S632F	STARD13_uc001uuu.2_Missense_Mutation_p.S624F|STARD13_uc001uuv.2_Missense_Mutation_p.S514F|STARD13_uc001uux.2_Missense_Mutation_p.S597F|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.S617F	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	632					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)														---	---	---	---
RFC3	5983	broad.mit.edu	37	13	34410364	34410364	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:34410364T>C	uc001uuz.2	+	9	1113	c.1003T>C	c.(1003-1005)TTT>CTT	p.F335L	RFC3_uc001uva.2_Intron	NM_002915	NP_002906	P40938	RFC3_HUMAN	replication factor C 3 isoform 1	335					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding				0		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35632906	35632906	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35632906T>C	uc001uvb.2	+	9	1351	c.1145T>C	c.(1144-1146)GTA>GCA	p.V382A		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	382						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35738555	35738555	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35738555A>G	uc001uvb.2	+	25	4348	c.4142A>G	c.(4141-4143)AAC>AGC	p.N1381S	NBEA_uc010abi.2_Missense_Mutation_p.N72S	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1381						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding	p.N1381fs*28(1)		ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
NBEA	26960	broad.mit.edu	37	13	35782886	35782886	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:35782886A>G	uc001uvb.2	+	32	5622	c.5416A>G	c.(5416-5418)ACC>GCC	p.T1806A	NBEA_uc010abi.2_Missense_Mutation_p.T462A	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1806						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)														---	---	---	---
CCNA1	8900	broad.mit.edu	37	13	37014180	37014180	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37014180A>G	uc001uvr.3	+	6	1308	c.958A>G	c.(958-960)ACA>GCA	p.T320A	CCNA1_uc010teo.1_Missense_Mutation_p.T276A|CCNA1_uc010abq.2_Missense_Mutation_p.T276A|CCNA1_uc010abp.2_Missense_Mutation_p.T276A|CCNA1_uc001uvs.3_Missense_Mutation_p.T319A|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	320					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)														---	---	---	---
FAM48A	55578	broad.mit.edu	37	13	37598550	37598550	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37598550C>T	uc001uwg.2	-	18	1607	c.1359G>A	c.(1357-1359)TCG>TCA	p.S453S	FAM48A_uc010abt.2_Silent_p.S454S|FAM48A_uc001uwh.2_Silent_p.S454S|FAM48A_uc001uwi.2_Silent_p.S453S|FAM48A_uc001uwj.2_Silent_p.S454S|FAM48A_uc001uwk.2_Silent_p.S453S|FAM48A_uc010tes.1_Silent_p.S417S|FAM48A_uc001uwl.1_Silent_p.S453S|FAM48A_uc001uwd.2_5'Flank|FAM48A_uc001uwe.2_5'UTR|FAM48A_uc001uwf.2_Silent_p.S31S	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	453					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)														---	---	---	---
POSTN	10631	broad.mit.edu	37	13	38153249	38153249	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:38153249T>C	uc001uwo.3	-	14	1919	c.1801A>G	c.(1801-1803)ACA>GCA	p.T601A	POSTN_uc010tet.1_Missense_Mutation_p.T129A|POSTN_uc001uwp.3_Missense_Mutation_p.T601A|POSTN_uc001uwr.2_Missense_Mutation_p.T601A|POSTN_uc001uwq.2_Missense_Mutation_p.T601A|POSTN_uc010teu.1_Missense_Mutation_p.T601A|POSTN_uc010tev.1_Missense_Mutation_p.T601A|POSTN_uc010tew.1_Missense_Mutation_p.T601A	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	601	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)														---	---	---	---
POSTN	10631	broad.mit.edu	37	13	38153993	38153993	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:38153993C>T	uc001uwo.3	-						POSTN_uc010tet.1_Intron|POSTN_uc001uwp.3_Intron|POSTN_uc001uwr.2_Intron|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Intron|POSTN_uc010tev.1_Intron|POSTN_uc010tew.1_Intron|POSTN_uc010tex.1_Intron	NM_006475	NP_006466			periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)														---	---	---	---
FREM2	341640	broad.mit.edu	37	13	39263610	39263610	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39263610G>A	uc001uwv.2	+	1	2438	c.2129G>A	c.(2128-2130)CGT>CAT	p.R710H		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	710	CSPG 4.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)														---	---	---	---
STOML3	161003	broad.mit.edu	37	13	39544433	39544433	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39544433A>G	uc001uwx.2	-	5	543	c.405T>C	c.(403-405)GAT>GAC	p.D135D	STOML3_uc010tez.1_Silent_p.D126D	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	135	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)														---	---	---	---
STOML3	161003	broad.mit.edu	37	13	39546706	39546706	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39546706T>C	uc001uwx.2	-	4	393	c.255A>G	c.(253-255)ATA>ATG	p.I85M	STOML3_uc010tez.1_Missense_Mutation_p.I76M	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	85	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)														---	---	---	---
KBTBD7	84078	broad.mit.edu	37	13	41766825	41766825	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41766825A>G	uc001uxw.1	-	1	1878	c.1569T>C	c.(1567-1569)GAT>GAC	p.D523D	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	523	Kelch 3.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)														---	---	---	---
C13orf31	144811	broad.mit.edu	37	13	44463029	44463029	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:44463029A>G	uc010acg.2	+	5	1529	c.1044A>G	c.(1042-1044)GAA>GAG	p.E348E	C13orf31_uc001uzf.3_Silent_p.E348E	NM_001128303	NP_001121775	Q8IV20	CM031_HUMAN	hypothetical protein LOC144811	348											0		Lung NSC(96;0.000163)|all_hematologic(4;0.0127)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Breast(139;0.0364)|Lung SC(185;0.0367)|Acute lymphoblastic leukemia(4;0.138)		GBM - Glioblastoma multiforme(144;0.000573)|BRCA - Breast invasive adenocarcinoma(63;0.121)														---	---	---	---
KCTD4	386618	broad.mit.edu	37	13	45768415	45768415	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45768415T>C	uc001uzx.3	-	2	692	c.288A>G	c.(286-288)GGA>GGG	p.G96G	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	96	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)														---	---	---	---
ZC3H13	23091	broad.mit.edu	37	13	46541688	46541688	+	Silent	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46541688C>G	uc010tfw.1	-	14	4278	c.4272G>C	c.(4270-4272)GTG>GTC	p.V1424V	ZC3H13_uc001vaq.2_Silent_p.V8V|ZC3H13_uc001vas.1_Silent_p.V1424V	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1424							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)														---	---	---	---
ZC3H13	23091	broad.mit.edu	37	13	46544099	46544099	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46544099T>C	uc010tfw.1	-	13	2586	c.2580A>G	c.(2578-2580)AAA>AAG	p.K860K	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Silent_p.K860K|ZC3H13_uc001vat.1_Silent_p.K860K	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	860							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)														---	---	---	---
SUCLA2	8803	broad.mit.edu	37	13	48528267	48528267	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48528267G>A	uc001vbs.2	-						SUCLA2_uc010tgb.1_Intron|SUCLA2_uc010tgc.1_Intron|SUCLA2_uc010tgd.1_Intron|SUCLA2_uc001vbt.1_Intron	NM_003850	NP_003841			succinate-CoA ligase, ADP-forming, beta subunit						succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)	1		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)													---	---	---	---
RB1	5925	broad.mit.edu	37	13	48919305	48919305	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:48919305T>C	uc001vcb.2	+	4	636	c.470T>C	c.(469-471)GTA>GCA	p.V157A	RB1_uc010acs.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	157					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49580394	49580394	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49580394C>T	uc001vcm.2	+	2	373	c.68C>T	c.(67-69)GCC>GTC	p.A23V	FNDC3A_uc001vcl.1_Missense_Mutation_p.A23V|FNDC3A_uc001vcn.2_Missense_Mutation_p.A23V|FNDC3A_uc001vco.2_RNA	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	23						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
FAM124A	220108	broad.mit.edu	37	13	51826294	51826294	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51826294G>A	uc001vfg.1	+	3	922	c.791G>A	c.(790-792)CGC>CAC	p.R264H	FAM124A_uc001vfe.2_Missense_Mutation_p.R264H|FAM124A_uc001vff.1_Missense_Mutation_p.R300H	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	264										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)														---	---	---	---
ATP7B	540	broad.mit.edu	37	13	52548584	52548584	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52548584T>C	uc001vfw.2	-	2	929	c.772A>G	c.(772-774)ACC>GCC	p.T258A	ATP7B_uc010adv.2_Missense_Mutation_p.T258A|ATP7B_uc001vfx.2_Missense_Mutation_p.T258A|ATP7B_uc001vfy.2_Missense_Mutation_p.T258A|ATP7B_uc010tgt.1_Missense_Mutation_p.T258A|ATP7B_uc010tgu.1_Missense_Mutation_p.T258A|ATP7B_uc010tgv.1_Missense_Mutation_p.T258A|ATP7B_uc010tgw.1_Missense_Mutation_p.T226A	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	258	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)										Wilson_disease				---	---	---	---
THSD1	55901	broad.mit.edu	37	13	52971767	52971767	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52971767T>C	uc001vgo.2	-	3	1166	c.621A>G	c.(619-621)GCA>GCG	p.A207A	THSD1_uc001vgp.2_Silent_p.A207A|THSD1_uc010tgz.1_Intron|THSD1_uc010aea.2_Intron	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	207	Extracellular (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)														---	---	---	---
CKAP2	26586	broad.mit.edu	37	13	53035683	53035683	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53035683T>C	uc001vgv.2	+	4	922	c.725T>C	c.(724-726)TTT>TCT	p.F242S	CKAP2_uc001vgt.2_Missense_Mutation_p.F241S|CKAP2_uc001vgu.2_Missense_Mutation_p.F241S|CKAP2_uc010tha.1_Missense_Mutation_p.F193S	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	242					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)														---	---	---	---
LECT1	11061	broad.mit.edu	37	13	53307345	53307345	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53307345T>C	uc001vhf.2	-						LECT1_uc001vhg.2_Intron|LECT1_uc001vhh.2_Intron	NM_007015	NP_008946			leukocyte cell derived chemotaxin 1 isoform 1						cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)														---	---	---	---
LECT1	11061	broad.mit.edu	37	13	53313758	53313758	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53313758T>C	uc001vhf.2	-						LECT1_uc001vhg.2_Intron|LECT1_uc001vhh.2_Intron	NM_007015	NP_008946			leukocyte cell derived chemotaxin 1 isoform 1						cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				ovary(2)	2		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58299162	58299162	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58299162T>C	uc001vhq.1	+	4	4106	c.3214T>C	c.(3214-3216)TTG>CTG	p.L1072L	PCDH17_uc010aec.1_Silent_p.L1071L|PCDH17_uc001vhr.1_Silent_p.L161L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1072	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
DACH1	1602	broad.mit.edu	37	13	72053400	72053400	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:72053400C>T	uc010thn.1	-	9	2194	c.1771G>A	c.(1771-1773)GTC>ATC	p.V591I	DACH1_uc010tho.1_Missense_Mutation_p.V443I|DACH1_uc010thp.1_Missense_Mutation_p.V389I	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	643	DACHbox-C.|Potential.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)														---	---	---	---
C13orf37	440145	broad.mit.edu	37	13	73301654	73301654	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:73301654A>G	uc001viu.2	-						C13orf34_uc010thq.1_5'Flank|C13orf34_uc001viv.1_5'Flank|C13orf34_uc010aen.1_5'Flank|C13orf34_uc010thr.1_5'Flank|C13orf34_uc001viw.1_5'Flank	NM_001071775	NP_001065243			hypothetical protein LOC440145						gamma-tubulin complex localization	centrosome|gamma-tubulin ring complex|spindle	protein binding				0																		---	---	---	---
DIS3	22894	broad.mit.edu	37	13	73349347	73349347	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:73349347A>G	uc001vix.3	-	6	1361	c.987_splice	c.e6+1	p.M329_splice	DIS3_uc001viy.3_Splice_Site_p.M299_splice|DIS3_uc001viz.2_Splice_Site	NM_014953	NP_055768			DIS3 mitotic control isoform a						CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)											Multiple Myeloma(4;0.011)			---	---	---	---
PIBF1	10464	broad.mit.edu	37	13	73357645	73357645	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:73357645A>G	uc001vjc.2	+	2	343	c.38A>G	c.(37-39)AAC>AGC	p.N13S	PIBF1_uc001vja.1_Missense_Mutation_p.N13S|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.N13S|PIBF1_uc010aep.2_Intron|DIS3_uc001viy.3_5'Flank|DIS3_uc001vix.3_5'Flank|DIS3_uc001viz.2_5'Flank	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	13						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)														---	---	---	---
KLF12	11278	broad.mit.edu	37	13	74289502	74289502	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:74289502T>C	uc001vjf.2	-						KLF12_uc010aeq.2_Intron	NM_007249	NP_009180			Kruppel-like factor 12						negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)														---	---	---	---
COMMD6	170622	broad.mit.edu	37	13	76100731	76100731	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76100731C>T	uc001vjo.1	-	4	302	c.252G>A	c.(250-252)ACG>ACA	p.T84T	COMMD6_uc001vjn.1_Silent_p.T97T|COMMD6_uc010aet.1_RNA|COMMD6_uc001vjp.1_RNA	NM_203495	NP_987091	Q7Z4G1	COMD6_HUMAN	COMM domain containing 6 isoform b	84	COMM.					cytoplasm|nucleus	protein binding				0		Breast(118;0.0979)|Prostate(6;0.122)		GBM - Glioblastoma multiforme(99;0.0104)														---	---	---	---
LMO7	4008	broad.mit.edu	37	13	76407252	76407252	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:76407252T>C	uc001vjv.2	+	13	3076	c.2316T>C	c.(2314-2316)TTT>TTC	p.F772F	LMO7_uc010thv.1_Silent_p.F723F|LMO7_uc001vjt.1_Silent_p.F671F|LMO7_uc010thw.1_Silent_p.F622F|LMO7_uc001vjw.1_Silent_p.F678F	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	1057	PDZ.					cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)														---	---	---	---
FBXL3	26224	broad.mit.edu	37	13	77581883	77581883	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77581883T>C	uc001vkd.2	-	5	1055	c.684A>G	c.(682-684)GAA>GAG	p.E228E		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	228	LRR 3.				regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)														---	---	---	---
FBXL3	26224	broad.mit.edu	37	13	77592813	77592813	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77592813T>C	uc001vkd.2	-	3	764	c.393A>G	c.(391-393)CTA>CTG	p.L131L		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	131	LRR 1.				regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)														---	---	---	---
EDNRB	1910	broad.mit.edu	37	13	78475265	78475265	+	Nonsense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78475265A>C	uc001vko.2	-	4	1137	c.879T>G	c.(877-879)TAT>TAG	p.Y293*	EDNRB_uc001vkq.1_Nonsense_Mutation_p.Y293*|uc001vkn.1_Intron|EDNRB_uc010aez.1_Nonsense_Mutation_p.Y293*|EDNRB_uc001vkp.1_Nonsense_Mutation_p.Y376*	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	293	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)													---	---	---	---
POU4F1	5457	broad.mit.edu	37	13	79175650	79175650	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:79175650G>A	uc001vkv.2	-	2	1394	c.1160C>T	c.(1159-1161)GCC>GTC	p.A387V	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	387	Homeobox.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)														---	---	---	---
SLITRK6	84189	broad.mit.edu	37	13	86368224	86368224	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:86368224C>T	uc001vll.1	-	2	2879	c.2420G>A	c.(2419-2421)CGT>CAT	p.R807H	SLITRK6_uc010afe.1_Missense_Mutation_p.R260H	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	807	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)														---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88329969	88329969	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88329969T>C	uc001vln.2	+	2	2545	c.2326T>C	c.(2326-2328)TAC>CAC	p.Y776H	SLITRK5_uc010tic.1_Missense_Mutation_p.Y535H	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	776	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)																	---	---	---	---
SLITRK5	26050	broad.mit.edu	37	13	88330275	88330275	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88330275C>T	uc001vln.2	+	2	2851	c.2632C>T	c.(2632-2634)CCC>TCC	p.P878S	SLITRK5_uc010tic.1_Missense_Mutation_p.P637S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	878	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)																	---	---	---	---
GPC5	2262	broad.mit.edu	37	13	92051382	92051382	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:92051382C>T	uc010tif.1	+	1	448	c.82C>T	c.(82-84)CAG>TAG	p.Q28*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	28						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)																---	---	---	---
DCT	1638	broad.mit.edu	37	13	95131364	95131364	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95131364G>A	uc001vlv.3	-	1	573	c.146C>T	c.(145-147)GCC>GTC	p.A49V	DCT_uc010afh.2_Missense_Mutation_p.A49V	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	49	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)														---	---	---	---
TGDS	23483	broad.mit.edu	37	13	95230367	95230367	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95230367T>C	uc001vlw.2	-	9	838	c.717A>G	c.(715-717)GTA>GTG	p.V239V	TGDS_uc001vlx.2_RNA	NM_014305	NP_055120	O95455	TGDS_HUMAN	TDP-glucose 4,6-dehydratase	239					cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
TGDS	23483	broad.mit.edu	37	13	95243105	95243105	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95243105A>G	uc001vlw.2	-	4	434	c.313_splice	c.e4+1	p.D105_splice	TGDS_uc001vlx.2_Intron	NM_014305	NP_055120			TDP-glucose 4,6-dehydratase						cellular metabolic process		coenzyme binding|dTDP-glucose 4,6-dehydratase activity|protein binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95695936	95695936	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95695936C>T	uc001vmd.3	-	29	3854	c.3735G>A	c.(3733-3735)ATG>ATA	p.M1245I	ABCC4_uc010afj.2_Intron|ABCC4_uc010afk.2_Missense_Mutation_p.M1198I	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	1245	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
DNAJC3	5611	broad.mit.edu	37	13	96361576	96361576	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96361576T>C	uc001vmq.2	+	2	286	c.178T>C	c.(178-180)TTT>CTT	p.F60L	DNAJC3_uc001vmp.2_Missense_Mutation_p.F60L|DNAJC3_uc001vmr.2_Missense_Mutation_p.F60L	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	60	TPR 1.				protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)															---	---	---	---
FARP1	10160	broad.mit.edu	37	13	99020379	99020379	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99020379C>T	uc001vnj.2	+	5	664	c.328C>T	c.(328-330)CAC>TAC	p.H110Y	FARP1_uc001vnh.2_Missense_Mutation_p.H110Y	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	110	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)															---	---	---	---
FARP1	10160	broad.mit.edu	37	13	99092982	99092982	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99092982G>A	uc001vnj.2	+	24	3024	c.2688G>A	c.(2686-2688)TCG>TCA	p.S896S	FARP1_uc001vnh.2_Silent_p.S927S	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	896					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)															---	---	---	---
SLC15A1	6564	broad.mit.edu	37	13	99337071	99337071	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99337071G>A	uc001vno.2	-	23	2111	c.2034C>T	c.(2032-2034)ATC>ATT	p.I678I		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	678	Cytoplasmic (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)													---	---	---	---
PCCA	5095	broad.mit.edu	37	13	101077939	101077939	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101077939C>T	uc001voo.2	+	20	1837	c.1799C>T	c.(1798-1800)TCG>TTG	p.S600L	PCCA_uc010aga.2_Missense_Mutation_p.S574L|PCCA_uc010tiz.1_Missense_Mutation_p.S600L|PCCA_uc001vop.2_RNA	NM_000282	NP_000273	P05165	PCCA_HUMAN	propionyl-Coenzyme A carboxylase, alpha	600					fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			skin(2)	2	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)													---	---	---	---
TMTC4	84899	broad.mit.edu	37	13	101288800	101288800	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101288800G>A	uc001vou.2	-	9	1291	c.1131C>T	c.(1129-1131)GAC>GAT	p.D377D	TMTC4_uc001vot.2_Silent_p.D396D|TMTC4_uc010tja.1_Silent_p.D266D|TMTC4_uc001vov.1_Silent_p.D122D|TMTC4_uc001vow.1_Silent_p.D160D	NM_001079669	NP_001073137	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat	377						integral to membrane	binding			ovary(2)|breast(1)	3	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
NALCN	259232	broad.mit.edu	37	13	101755586	101755586	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:101755586T>C	uc001vox.1	-	26	3183	c.2994A>G	c.(2992-2994)AAA>AAG	p.K998K		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	998	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
TPP2	7174	broad.mit.edu	37	13	103286306	103286306	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103286306C>T	uc001vpi.3	+	11	1354	c.1251C>T	c.(1249-1251)GAC>GAT	p.D417D		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	417					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)																	---	---	---	---
C13orf27	93081	broad.mit.edu	37	13	103421785	103421785	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103421785T>A	uc001vpo.2	-	3	300	c.122A>T	c.(121-123)GAT>GTT	p.D41V	C13orf27_uc001vpn.2_5'UTR|C13orf27_uc001vpp.2_5'UTR	NM_138779	NP_620134	Q5JUR7	CM027_HUMAN	hypothetical protein LOC93081	41											0	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)																	---	---	---	---
BIVM	54841	broad.mit.edu	37	13	103468911	103468911	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103468911T>C	uc001vps.2	+						BIVM_uc010agc.2_Intron|BIVM_uc001vpt.2_3'UTR|ERCC5_uc001vpu.1_Intron	NM_017693	NP_060163			basic, immunoglobulin-like variable motif							cytoplasm|nucleus					0	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)																	---	---	---	---
ERCC5	2073	broad.mit.edu	37	13	103514541	103514541	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103514541A>G	uc001vpw.2	+	8	1485	c.1042A>G	c.(1042-1044)ATG>GTG	p.M348V	ERCC5_uc001vpu.1_Missense_Mutation_p.M802V|ERCC5_uc010tjb.1_Missense_Mutation_p.M348V|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.M180V	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	348					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)							Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
COL4A2	1284	broad.mit.edu	37	13	111082993	111082993	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111082993G>A	uc001vqx.2	+							NM_001846	NP_001837			alpha 2 type IV collagen preproprotein						angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)															---	---	---	---
ARHGEF7	8874	broad.mit.edu	37	13	111930027	111930027	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:111930027C>T	uc001vrs.2	+						ARHGEF7_uc001vrr.2_Intron|ARHGEF7_uc001vrt.2_Intron|ARHGEF7_uc010tjn.1_Intron|ARHGEF7_uc001vru.1_Intron|ARHGEF7_uc001vrv.3_Intron|ARHGEF7_uc001vrw.3_Intron|ARHGEF7_uc001vrx.3_Intron|ARHGEF7_uc010tjo.1_Intron|ARHGEF7_uc010tjp.1_Intron	NM_001113511	NP_001106983			PAK-interacting exchange factor beta isoform c						apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)															---	---	---	---
TUBGCP3	10426	broad.mit.edu	37	13	113159011	113159011	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113159011G>A	uc001vse.1	-	18	2291	c.2104C>T	c.(2104-2106)CAC>TAC	p.H702Y	TUBGCP3_uc010tjq.1_Missense_Mutation_p.H692Y|TUBGCP3_uc001vsf.2_Missense_Mutation_p.H702Y	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	702					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)																	---	---	---	---
ATP11A	23250	broad.mit.edu	37	13	113470490	113470490	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113470490A>G	uc001vsi.3	+	6	623	c.535A>G	c.(535-537)ACC>GCC	p.T179A	ATP11A_uc001vsj.3_Missense_Mutation_p.T179A|ATP11A_uc001vsm.1_Missense_Mutation_p.T55A	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	179	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)																---	---	---	---
MCF2L	23263	broad.mit.edu	37	13	113718664	113718664	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113718664A>G	uc001vsu.2	+	6	729	c.707A>G	c.(706-708)AAG>AGG	p.K236R	MCF2L_uc001vsq.2_Missense_Mutation_p.K236R|MCF2L_uc010tjr.1_Missense_Mutation_p.K179R|MCF2L_uc001vsr.2_Missense_Mutation_p.K183R|MCF2L_uc001vss.3_Missense_Mutation_p.K177R|MCF2L_uc010tjs.1_Missense_Mutation_p.K177R|MCF2L_uc001vst.1_Missense_Mutation_p.K141R	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	209	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)																---	---	---	---
MCF2L	23263	broad.mit.edu	37	13	113739245	113739245	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113739245A>C	uc001vsu.2	+	19	2294	c.2272A>C	c.(2272-2274)AAG>CAG	p.K758Q	MCF2L_uc001vsq.2_Missense_Mutation_p.K758Q|MCF2L_uc010tjr.1_Missense_Mutation_p.K701Q|MCF2L_uc001vsr.2_Missense_Mutation_p.K705Q|MCF2L_uc001vss.3_Missense_Mutation_p.K699Q|MCF2L_uc010tjs.1_Missense_Mutation_p.K699Q|MCF2L_uc001vst.1_Missense_Mutation_p.K663Q	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	731	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)																---	---	---	---
ADPRHL1	113622	broad.mit.edu	37	13	114083383	114083383	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114083383G>C	uc001vtq.1	-	4	617	c.530C>G	c.(529-531)GCC>GGC	p.A177G	ADPRHL1_uc001vtp.1_Missense_Mutation_p.A95G	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	177					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)															---	---	---	---
TFDP1	7027	broad.mit.edu	37	13	114287550	114287550	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114287550C>T	uc001vtw.2	+	6	636	c.424C>T	c.(424-426)CTG>TTG	p.L142L	TFDP1_uc010tkd.1_Silent_p.L47L|TFDP1_uc010tke.1_Silent_p.L47L|TFDP1_uc001vty.3_Silent_p.L142L|TFDP1_uc001vtx.2_Silent_p.L22L|TFDP1_uc010agx.2_Silent_p.L142L	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	142	Potential.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)												TSP Lung(29;0.18)			---	---	---	---
FAM70B	348013	broad.mit.edu	37	13	114469097	114469097	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114469097C>T	uc001vuh.2	+	2	83	c.56C>T	c.(55-57)TCG>TTG	p.S19L	FAM70B_uc010tkh.1_Missense_Mutation_p.S19L	NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	19						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)															---	---	---	---
GAS6	2621	broad.mit.edu	37	13	114523949	114523949	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114523949C>T	uc001vud.2	-	15	2078	c.1925G>A	c.(1924-1926)GGC>GAC	p.G642D	GAS6_uc001vug.2_Missense_Mutation_p.G343D|GAS6_uc001vuf.2_Missense_Mutation_p.G369D	NM_000820	NP_000811	Q14393	GAS6_HUMAN	growth arrest-specific 6 isoform 1 precursor	685	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)	4	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)																---	---	---	---
CDC16	8881	broad.mit.edu	37	13	115022679	115022679	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115022679C>T	uc001vuk.1	+	13	1422	c.1224C>T	c.(1222-1224)GTC>GTT	p.V408V	CDC16_uc001vul.1_Silent_p.V408V|CDC16_uc001vum.1_Silent_p.V314V|CDC16_uc001vun.1_Silent_p.V407V|CDC16_uc001vuo.1_Intron	NM_003903	NP_003894	Q13042	CDC16_HUMAN	anaphase-promoting complex, subunit 6	408	TPR 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding				0	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)															---	---	---	---
UPF3A	65110	broad.mit.edu	37	13	115051798	115051798	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115051798T>C	uc001vup.2	+	4	480	c.443T>C	c.(442-444)GTA>GCA	p.V148A	UPF3A_uc001vuq.2_Intron|UPF3A_uc001vus.2_Intron|UPF3A_uc001vur.2_RNA|UPF3A_uc001vut.2_5'UTR|UPF3A_uc001vuu.2_5'UTR	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	148					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)														---	---	---	---
OR4K2	390431	broad.mit.edu	37	14	20344705	20344705	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20344705T>A	uc001vwh.1	+	1	279	c.279T>A	c.(277-279)TCT>TCA	p.S93S		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)														---	---	---	---
OR4K17	390436	broad.mit.edu	37	14	20586234	20586234	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20586234A>G	uc001vwo.1	+	1	669	c.669A>G	c.(667-669)ATA>ATG	p.I223M		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)														---	---	---	---
CCNB1IP1	57820	broad.mit.edu	37	14	20781885	20781885	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20781885A>G	uc001vwv.2	-	6	1022	c.373T>C	c.(373-375)TAT>CAT	p.Y125H	CCNB1IP1_uc001vww.2_Missense_Mutation_p.Y125H|CCNB1IP1_uc001vwx.2_Missense_Mutation_p.Y125H|CCNB1IP1_uc001vwy.2_Missense_Mutation_p.Y125H|CCNB1IP1_uc001vwz.2_Missense_Mutation_p.Y125H	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	125						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)				T	HMGA2	leiomyoma								---	---	---	---
PARP2	10038	broad.mit.edu	37	14	20813565	20813565	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20813565C>T	uc001vxc.2	+	3	282	c.254C>T	c.(253-255)GCC>GTC	p.A85V	RPPH1_uc001vxa.1_5'Flank|PARP2_uc001vxd.2_Missense_Mutation_p.A72V|PARP2_uc001vxb.1_Missense_Mutation_p.A85V	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	85	Potential.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)									Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					---	---	---	---
APEX1	328	broad.mit.edu	37	14	20923812	20923812	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20923812A>G	uc001vxg.2	+	2	340	c.8A>G	c.(7-9)AAG>AGG	p.K3R	OSGEP_uc001vxf.2_5'Flank|APEX1_uc001vxh.2_Missense_Mutation_p.K3R|APEX1_uc001vxi.2_Missense_Mutation_p.K3R|APEX1_uc001vxj.2_Missense_Mutation_p.K3R	NM_001641	NP_001632	P27695	APEX1_HUMAN	APEX nuclease 1	3	Necessary for interaction with YBX1, binding to RNA, NPM1-dependent association with rRNA, endoribonuclease activity on abasic RNA and localization in the nucleoli.				base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			ovary(2)|breast(2)	4	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)								Direct_reversal_of_damage|Other_BER_factors					---	---	---	---
RNASE9	390443	broad.mit.edu	37	14	21025069	21025069	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21025069T>C	uc010aho.2	-	4	319	c.160A>G	c.(160-162)ACA>GCA	p.T54A	RNASE9_uc001vxq.3_Missense_Mutation_p.T59A|RNASE9_uc010ahp.2_Missense_Mutation_p.T59A|RNASE9_uc010ahq.2_Missense_Mutation_p.T59A|RNASE9_uc010ahr.2_Missense_Mutation_p.T59A|RNASE9_uc010ahs.2_Missense_Mutation_p.T54A|RNASE9_uc010aht.2_Missense_Mutation_p.T54A|RNASE9_uc010ahu.2_Missense_Mutation_p.T54A	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	54						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)														---	---	---	---
METT11D1	64745	broad.mit.edu	37	14	21460342	21460342	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21460342A>G	uc001vyn.2	+	4	621	c.424A>G	c.(424-426)ACC>GCC	p.T142A	METT11D1_uc010tlk.1_Silent_p.L152L|METT11D1_uc001vym.2_Missense_Mutation_p.T142A|METT11D1_uc001vyo.2_Missense_Mutation_p.T142A|METT11D1_uc001vyp.2_5'UTR|METT11D1_uc001vyq.2_5'UTR	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	142					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
NDRG2	57447	broad.mit.edu	37	14	21486152	21486152	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21486152C>T	uc001vyy.2	-	16	1093	c.943G>A	c.(943-945)GGC>AGC	p.G315S	NDRG2_uc010tll.1_Missense_Mutation_p.G311S|NDRG2_uc001vyt.2_Missense_Mutation_p.G228S|NDRG2_uc001vyu.2_Missense_Mutation_p.G272S|NDRG2_uc001vyv.2_Missense_Mutation_p.G301S|NDRG2_uc001vyw.2_Missense_Mutation_p.G301S|NDRG2_uc001vzb.2_Missense_Mutation_p.G255S|NDRG2_uc001vyx.2_Missense_Mutation_p.G315S|NDRG2_uc001vza.2_Missense_Mutation_p.G301S|NDRG2_uc001vyz.2_Missense_Mutation_p.G301S|NDRG2_uc001vzc.2_Missense_Mutation_p.G285S|NDRG2_uc001vze.2_Missense_Mutation_p.G315S|NDRG2_uc001vzd.2_Missense_Mutation_p.G315S|NDRG2_uc001vzg.2_Missense_Mutation_p.G301S|NDRG2_uc001vzf.2_Missense_Mutation_p.G301S|NDRG2_uc010aig.2_Missense_Mutation_p.G304S	NM_201540	NP_963834	Q9UN36	NDRG2_HUMAN	N-myc downstream-regulated gene 2 isoform a	315					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				ovary(1)|breast(1)	2	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
RNASE13	440163	broad.mit.edu	37	14	21502245	21502245	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21502245C>T	uc001vzj.2	-	2	341	c.203G>A	c.(202-204)TGC>TAC	p.C68Y	NDRG2_uc010tll.1_Intron	NM_001012264	NP_001012264	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 precursor	68						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)														---	---	---	---
RPGRIP1	57096	broad.mit.edu	37	14	21771652	21771652	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21771652T>C	uc001wag.2	+	5	750	c.750T>C	c.(748-750)AAT>AAC	p.N250N		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	250					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
SUPT16H	11198	broad.mit.edu	37	14	21831045	21831045	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21831045G>A	uc001wao.2	-	14	1912	c.1573C>T	c.(1573-1575)CGG>TGG	p.R525W		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	525					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)														---	---	---	---
RAB2B	84932	broad.mit.edu	37	14	21931909	21931909	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21931909C>A	uc010tlt.1	-	6	481	c.380G>T	c.(379-381)AGG>ATG	p.R127M	RAB2B_uc010tls.1_Missense_Mutation_p.R81M|RAB2B_uc001wax.2_Missense_Mutation_p.R62M|RAB2B_uc010ain.2_Missense_Mutation_p.R18M	NM_032846	NP_116235	Q8WUD1	RAB2B_HUMAN	RAB2B protein isoform 1	127					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			ovary(1)	1	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22314979	22314979	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22314979T>C	uc010tmf.1	+						uc001wbw.2_Intron|uc010tmg.1_Intron|uc001wby.2_Intron|uc010ait.1_Silent_p.I12I|uc001wbz.1_Silent_p.I12I					SubName: Full=Putative uncharacterized protein ENSP00000374943;																												OREG0022570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
Unknown	0	broad.mit.edu	37	14	22789044	22789044	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22789044A>G	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc010tmo.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc010ajg.1_Intron|uc001wcx.3_Intron|uc001wdd.2_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc001wdj.2_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdr.2_Missense_Mutation_p.N86S					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22987474	22987474	+	Intron	SNP	G	A	A	rs150038840	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22987474G>A	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc001wcx.3_Intron|uc010ajj.1_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdv.3_Intron|uc001wec.2_Intron|uc001wee.3_Intron|uc010tmt.1_Intron|uc010ajv.1_Intron|uc001weg.2_Intron|uc001wei.2_Intron|uc001wej.2_Intron|uc001wek.2_Intron|uc001wel.2_Intron|uc001wem.3_Intron|uc001wen.1_Intron|uc001weo.2_Intron|uc001wep.2_Intron|uc001weq.2_Intron|uc001wer.2_Intron|uc001wet.2_Intron|uc001weu.2_Intron|uc001wev.2_Intron|uc001wew.2_Intron|uc010tmv.1_Intron|uc001wez.2_Intron|uc010ajx.1_Intron|uc001wfb.1_Intron|uc001wfd.1_Intron|uc001wfe.2_Intron|uc001wfg.2_Intron|uc001wfh.1_Intron|uc001wfi.2_Intron|uc001wfk.2_Intron|uc001wfl.2_Intron|uc010ajy.1_Intron|uc001wfn.2_Intron|uc001wfo.2_RNA|uc001wfp.2_Translation_Start_Site|uc001wfq.1_5'Flank|uc001wfr.1_5'Flank|uc010ajz.1_5'Flank					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22991074	22991074	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22991074A>G	uc001wbw.2	+						uc010aja.1_Intron|uc010tmk.1_Intron|uc001wco.2_Intron|uc010aje.1_Intron|uc001wcp.2_Intron|uc001wcr.1_Intron|uc001wcs.1_Intron|uc010ajf.1_Intron|uc001wcx.3_Intron|uc001wde.1_Intron|uc001wdf.2_Intron|uc010ajk.1_Intron|uc001wdg.1_Intron|uc010ajl.1_Intron|uc010ajo.1_Intron|uc010ajp.1_Intron|uc001wdv.3_Intron|uc001wec.2_Intron|uc001wee.3_Intron|uc010tmt.1_Intron|uc010ajv.1_Intron|uc001weg.2_Intron|uc001wei.2_Intron|uc001wej.2_Intron|uc001wek.2_Intron|uc001wel.2_Intron|uc001wem.3_Intron|uc001wen.1_Intron|uc001weo.2_Intron|uc001wep.2_Intron|uc001weq.2_Intron|uc001wer.2_Intron|uc001wet.2_Intron|uc001weu.2_Intron|uc001wev.2_Intron|uc001wew.2_Intron|uc010tmv.1_Intron|uc001wez.2_Intron|uc010ajx.1_Intron|uc001wfb.1_Intron|uc001wfd.1_Intron|uc001wfe.2_Intron|uc001wfg.2_Intron|uc001wfh.1_Intron|uc001wfi.2_Intron|uc001wfk.2_Intron|uc001wfl.2_Intron|uc010ajy.1_Intron|uc001wfn.2_Intron|uc001wfp.2_Intron|uc001wfq.1_Intron|uc001wfr.1_Intron|uc010ajz.1_Intron|uc001wfs.1_RNA|uc001wft.1_5'Flank|uc001wfu.2_5'Flank|uc001wfv.1_5'Flank					SubName: Full=Alpha-chain C region; Flags: Fragment;																														---	---	---	---
ABHD4	63874	broad.mit.edu	37	14	23072501	23072501	+	Nonsense_Mutation	SNP	C	T	T	rs148116289		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23072501C>T	uc001wgm.2	+	3	388	c.319C>T	c.(319-321)CGA>TGA	p.R107*	ABHD4_uc010tmz.1_Nonsense_Mutation_p.R107*|ABHD4_uc010tna.1_Nonsense_Mutation_p.R107*|ABHD4_uc010tnb.1_RNA	NM_022060	NP_071343	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	107					lipid catabolic process		hydrolase activity			central_nervous_system(1)	1	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)														---	---	---	---
REM2	161253	broad.mit.edu	37	14	23354218	23354218	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23354218A>C	uc001whf.1	+	2	504	c.439A>C	c.(439-441)AAC>CAC	p.N147H	REM2_uc010tnd.1_Missense_Mutation_p.N139H	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	147					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)														---	---	---	---
CDH24	64403	broad.mit.edu	37	14	23519067	23519067	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23519067G>A	uc001wil.2	-	10	1823	c.1563C>T	c.(1561-1563)TAC>TAT	p.Y521Y	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Silent_p.Y483Y	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	521	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23549358	23549358	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23549358G>A	uc001wit.3	-	6	1688	c.1360C>T	c.(1360-1362)CCT>TCT	p.P454S	ACIN1_uc001wis.3_Missense_Mutation_p.P136S|ACIN1_uc010akg.2_Missense_Mutation_p.P454S|ACIN1_uc010tnj.1_Missense_Mutation_p.P414S	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	454					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
EFS	10278	broad.mit.edu	37	14	23828545	23828545	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23828545T>C	uc001wjo.2	-	4	1750	c.1142A>G	c.(1141-1143)TAT>TGT	p.Y381C	EFS_uc001wjp.2_Missense_Mutation_p.Y288C|EFS_uc010tnm.1_Missense_Mutation_p.Y212C	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	381					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)														---	---	---	---
MYH7	4625	broad.mit.edu	37	14	23885260	23885260	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23885260C>T	uc001wjx.2	-	34	5012	c.4906G>A	c.(4906-4908)GCC>ACC	p.A1636T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1636	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)														---	---	---	---
NGDN	25983	broad.mit.edu	37	14	23946446	23946446	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23946446G>A	uc001wjy.2	+	9	778	c.751G>A	c.(751-753)GTC>ATC	p.V251I	NGDN_uc001wjz.2_Missense_Mutation_p.V251I|NGDN_uc001wka.2_RNA	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	251					regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)														---	---	---	---
CPNE6	9362	broad.mit.edu	37	14	24542843	24542843	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24542843C>T	uc001wll.2	+	3	403	c.304C>T	c.(304-306)CGA>TGA	p.R102*	CPNE6_uc010tnv.1_Nonsense_Mutation_p.R157*|CPNE6_uc001wlm.2_5'UTR|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	102	C2 1.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)														---	---	---	---
DCAF11	80344	broad.mit.edu	37	14	24588368	24588368	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24588368G>A	uc001wlv.2	+	9	1074	c.794G>A	c.(793-795)CGC>CAC	p.R265H	DCAF11_uc001wlw.2_Missense_Mutation_p.R265H|DCAF11_uc001wlz.2_Missense_Mutation_p.R165H|DCAF11_uc001wly.2_Missense_Mutation_p.R221H|DCAF11_uc001wme.2_Missense_Mutation_p.R225H|DCAF11_uc010tny.1_Missense_Mutation_p.R132H|DCAF11_uc001wmd.2_Missense_Mutation_p.R265H|DCAF11_uc001wmc.2_Missense_Mutation_p.R165H|DCAF11_uc001wmb.3_Missense_Mutation_p.R239H|DCAF11_uc001wma.3_Missense_Mutation_p.R265H	NM_001163484	NP_001156956	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11 isoform 1	265	WD 3.					CUL4 RING ubiquitin ligase complex	protein binding				0																		---	---	---	---
IRF9	10379	broad.mit.edu	37	14	24634066	24634066	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24634066T>C	uc001wmq.2	+	7	1020	c.893T>C	c.(892-894)ATC>ACC	p.I298T	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_Intron	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	298					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)														---	---	---	---
GMPR2	51292	broad.mit.edu	37	14	24707913	24707913	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24707913G>T	uc001wnr.2	+	10	1358	c.976G>T	c.(976-978)GAG>TAG	p.E326*	GMPR2_uc001wnv.2_Nonsense_Mutation_p.E163*|GMPR2_uc001wns.2_Nonsense_Mutation_p.E326*|GMPR2_uc001wnt.2_Nonsense_Mutation_p.E293*|GMPR2_uc001wnu.2_Nonsense_Mutation_p.E351*|GMPR2_uc001wnw.2_Nonsense_Mutation_p.E326*|GMPR2_uc010all.2_Nonsense_Mutation_p.E298*|GMPR2_uc001wnx.2_Nonsense_Mutation_p.E344*|GMPR2_uc010tod.1_Nonsense_Mutation_p.E293*|GMPR2_uc010alk.1_Nonsense_Mutation_p.E387*|GMPR2_uc010toe.1_Nonsense_Mutation_p.E387*	NM_001002001	NP_001002001	Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2 isoform 2	326					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			ovary(3)	3				GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
TGM1	7051	broad.mit.edu	37	14	24723893	24723893	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24723893G>A	uc001wod.2	-	13	2189	c.2065C>T	c.(2065-2067)CGC>TGC	p.R689C	TGM1_uc010tog.1_Missense_Mutation_p.R247C	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	689					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)													---	---	---	---
TGM1	7051	broad.mit.edu	37	14	24729876	24729876	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24729876C>T	uc001wod.2	-	4	661	c.537G>A	c.(535-537)ACG>ACA	p.T179T	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	179					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)													---	---	---	---
C14orf21	161424	broad.mit.edu	37	14	24773340	24773340	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24773340G>A	uc001wol.1	+	8	1567	c.1504G>A	c.(1504-1506)GTA>ATA	p.V502I	C14orf21_uc001wom.1_Missense_Mutation_p.V53I	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	502							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)														---	---	---	---
FOXG1	2290	broad.mit.edu	37	14	29237117	29237117	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:29237117T>C	uc001wqe.2	+	1	831	c.632T>C	c.(631-633)ATC>ACC	p.I211T		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	211	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)														---	---	---	---
FOXG1	2290	broad.mit.edu	37	14	29237605	29237605	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:29237605T>C	uc001wqe.2	+	1	1319	c.1120T>C	c.(1120-1122)TAC>CAC	p.Y374H		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	374					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)														---	---	---	---
PRKD1	5587	broad.mit.edu	37	14	30066890	30066890	+	Silent	SNP	G	A	A	rs147092748		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:30066890G>A	uc001wqh.2	-	16	2422	c.2241C>T	c.(2239-2241)CCC>CCT	p.P747P		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	747	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)														---	---	---	---
HECTD1	25831	broad.mit.edu	37	14	31597063	31597063	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31597063T>C	uc001wrc.1	-	26	5398	c.4909A>G	c.(4909-4911)ACT>GCT	p.T1637A	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.T1105A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1637	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)														---	---	---	---
HECTD1	25831	broad.mit.edu	37	14	31597105	31597105	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31597105T>C	uc001wrc.1	-	26	5356	c.4867A>G	c.(4867-4869)ACA>GCA	p.T1623A	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.T1091A	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1623	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)														---	---	---	---
HECTD1	25831	broad.mit.edu	37	14	31598572	31598572	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31598572T>C	uc001wrc.1	-	25	4494	c.4005A>G	c.(4003-4005)GCA>GCG	p.A1335A	HECTD1_uc001wrb.1_5'Flank|HECTD1_uc001wrd.1_Intron	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1335	MIB/HERC2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)														---	---	---	---
HECTD1	25831	broad.mit.edu	37	14	31605831	31605831	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31605831G>A	uc001wrc.1	-	20	3509	c.3020C>T	c.(3019-3021)CCT>CTT	p.P1007L	HECTD1_uc001wrd.1_Missense_Mutation_p.P522L	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1007					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)														---	---	---	---
ARHGAP5	394	broad.mit.edu	37	14	32562839	32562839	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:32562839A>G	uc001wrl.2	+	2	3203	c.2964A>G	c.(2962-2964)CCA>CCG	p.P988P	ARHGAP5_uc001wrm.2_Silent_p.P988P|ARHGAP5_uc001wrn.2_Silent_p.P988P|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	988					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)														---	---	---	---
AKAP6	9472	broad.mit.edu	37	14	33005003	33005003	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:33005003A>G	uc001wrq.2	+	3	738	c.568A>G	c.(568-570)ACA>GCA	p.T190A	AKAP6_uc010aml.2_Missense_Mutation_p.T187A	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	190					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)														---	---	---	---
AKAP6	9472	broad.mit.edu	37	14	33015103	33015103	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:33015103T>C	uc001wrq.2	+	4	1414	c.1244T>C	c.(1243-1245)GTT>GCT	p.V415A	AKAP6_uc010aml.2_Missense_Mutation_p.V412A	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	415					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)														---	---	---	---
PPP2R3C	55012	broad.mit.edu	37	14	35577396	35577396	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35577396A>G	uc001wss.2	-	5	805	c.451T>C	c.(451-453)TCA>CCA	p.S151P	PPP2R3C_uc001wst.2_Missense_Mutation_p.S35P|PPP2R3C_uc010tpr.1_Missense_Mutation_p.S35P|PPP2R3C_uc001wsu.2_RNA|PPP2R3C_uc010amn.1_Intron|uc001wsv.1_Intron|PPP2R3C_uc001wsw.2_Missense_Mutation_p.S151P|PPP2R3C_uc001wsx.1_Missense_Mutation_p.S151P	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	151						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)														---	---	---	---
INSM2	84684	broad.mit.edu	37	14	36004894	36004894	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36004894T>C	uc001wth.1	+	1	1647	c.1436T>C	c.(1435-1437)TTC>TCC	p.F479S		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	479	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)														---	---	---	---
MIPOL1	145282	broad.mit.edu	37	14	38016098	38016098	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38016098A>G	uc001wuc.2	+						MIPOL1_uc001wud.2_Intron|MIPOL1_uc010ams.2_Intron|MIPOL1_uc001wue.2_Intron|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059			mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)														---	---	---	---
CTAGE5	4253	broad.mit.edu	37	14	39782647	39782647	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39782647T>C	uc001wvg.3	+	14	1631	c.1295_splice	c.e14+2	p.R432_splice	CTAGE5_uc010tqe.1_Splice_Site_p.R394_splice|CTAGE5_uc001wuz.3_Splice_Site_p.R420_splice|CTAGE5_uc001wuy.3_Splice_Site_p.R352_splice|CTAGE5_uc001wvb.3_Splice_Site_p.R403_splice|CTAGE5_uc001wvc.3_Splice_Site_p.R377_splice|CTAGE5_uc001wva.3_Splice_Site_p.R403_splice|CTAGE5_uc001wvh.3_Splice_Site_p.R432_splice|CTAGE5_uc001wvf.3_Splice_Site_p.R357_splice|CTAGE5_uc001wvi.3_Splice_Site_p.R437_splice|CTAGE5_uc010amz.2_Splice_Site_p.R48_splice|CTAGE5_uc001wvj.3_Splice_Site_p.R403_splice	NM_005930	NP_005921			CTAGE family, member 5 isoform 1								enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)														---	---	---	---
C14orf28	122525	broad.mit.edu	37	14	45370048	45370048	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45370048A>G	uc001wvo.2	+	2	676	c.410A>G	c.(409-411)GAT>GGT	p.D137G	C14orf28_uc001wvp.1_Missense_Mutation_p.D137G	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	hypothetical protein LOC122525	137										ovary(1)	1																		---	---	---	---
FAM179B	23116	broad.mit.edu	37	14	45542710	45542710	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45542710T>C	uc001wvv.2	+	19	5318	c.5109T>C	c.(5107-5109)CAT>CAC	p.H1703H	FAM179B_uc001wvw.2_Silent_p.H1756H|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1703							binding			skin(2)|upper_aerodigestive_tract(1)	3																		---	---	---	---
FKBP3	2287	broad.mit.edu	37	14	45590703	45590703	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45590703T>C	uc010tqf.1	-	4	512	c.439A>G	c.(439-441)ACT>GCT	p.T147A		NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	147	PPIase FKBP-type.				protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0																		---	---	---	---
FANCM	57697	broad.mit.edu	37	14	45636264	45636264	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45636264A>G	uc001wwd.3	+	11	1999	c.1900A>G	c.(1900-1902)AAC>GAC	p.N634D	FANCM_uc001wwc.2_Missense_Mutation_p.N634D|FANCM_uc010anf.2_Missense_Mutation_p.N608D|FANCM_uc001wwe.3_Missense_Mutation_p.N170D	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	634					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7													Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
FANCM	57697	broad.mit.edu	37	14	45645728	45645728	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45645728T>C	uc001wwd.3	+	14	3870	c.3771T>C	c.(3769-3771)GAT>GAC	p.D1257D	FANCM_uc010anf.2_Silent_p.D1231D|FANCM_uc001wwe.3_Silent_p.D793D|FANCM_uc010ang.2_Silent_p.D471D	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1257					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7													Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
FANCM	57697	broad.mit.edu	37	14	45668046	45668046	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45668046A>G	uc001wwd.3	+	22	6015	c.5916A>G	c.(5914-5916)GCA>GCG	p.A1972A	FANCM_uc010anf.2_Silent_p.A1946A|FANCM_uc001wwe.3_Silent_p.A1508A|FANCM_uc010ang.2_Silent_p.A1221A	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1972	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7													Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
KLHDC1	122773	broad.mit.edu	37	14	50195672	50195672	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50195672C>T	uc001www.2	+	7	624	c.596C>T	c.(595-597)GCG>GTG	p.A199V	SDCCAG1_uc010anj.1_Intron|KLHDC1_uc010tqg.1_Missense_Mutation_p.A154V|KLHDC1_uc010tqh.1_Missense_Mutation_p.A114V	NM_172193	NP_751943	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	199						cytoplasm				pancreas(1)	1	all_epithelial(31;0.00244)|Breast(41;0.00964)																	---	---	---	---
KLHDC2	23588	broad.mit.edu	37	14	50246358	50246358	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50246358G>A	uc001wwx.2	+	7	1079	c.679G>A	c.(679-681)GGA>AGA	p.G227R	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.G227R|KLHDC2_uc010anp.2_Missense_Mutation_p.G227R	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	227						nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)																	---	---	---	---
ATP5S	27109	broad.mit.edu	37	14	50788253	50788253	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50788253A>G	uc001wxw.1	+	2	785	c.93A>G	c.(91-93)AAA>AAG	p.K31K	ATP5S_uc001wxv.2_Silent_p.K31K|ATP5S_uc001wxx.1_Silent_p.K31K|ATP5S_uc010ant.1_Intron	NM_001003803	NP_001003803	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	31					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			ovary(1)|skin(1)	2	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)														---	---	---	---
MAP4K5	11183	broad.mit.edu	37	14	50889831	50889831	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50889831A>G	uc001wya.2	-						MAP4K5_uc001wyb.2_Intron	NM_006575	NP_006566			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)																	---	---	---	---
NID2	22795	broad.mit.edu	37	14	52520419	52520419	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52520419G>A	uc001wzo.2	-	5	1541	c.1307C>T	c.(1306-1308)CCC>CTC	p.P436L	NID2_uc010tqs.1_Missense_Mutation_p.P436L|NID2_uc010tqt.1_Missense_Mutation_p.P436L|NID2_uc001wzp.2_Missense_Mutation_p.P436L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	436						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)																	---	---	---	---
PTGDR	5729	broad.mit.edu	37	14	52735128	52735128	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52735128A>G	uc001wzq.2	+	1	698	c.596A>G	c.(595-597)TAC>TGC	p.Y199C		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	199	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)													---	---	---	---
GPR137C	283554	broad.mit.edu	37	14	53101670	53101670	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53101670A>G	uc001wzu.3	+	7	1127	c.1127A>G	c.(1126-1128)CAA>CGA	p.Q376R	GPR137C_uc001wzt.3_Missense_Mutation_p.Q392R	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	376	Cytoplasmic (Potential).					integral to membrane					0	Breast(41;0.0716)																	---	---	---	---
FERMT2	10979	broad.mit.edu	37	14	53325164	53325164	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53325164T>C	uc001xad.2	-	15	2029	c.1974A>G	c.(1972-1974)ACA>ACG	p.T658T	FERMT2_uc001xac.2_Silent_p.T665T|FERMT2_uc001xae.2_Silent_p.T658T	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	658	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)																	---	---	---	---
BMP4	652	broad.mit.edu	37	14	54416799	54416799	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54416799A>G	uc001xal.3	-	3	1365	c.1178T>C	c.(1177-1179)GTA>GCA	p.V393A	BMP4_uc010aoh.2_Missense_Mutation_p.V393A|BMP4_uc001xao.3_Missense_Mutation_p.V393A|BMP4_uc001xan.3_Missense_Mutation_p.V393A	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	393					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0																		---	---	---	---
CGRRF1	10668	broad.mit.edu	37	14	54976688	54976688	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54976688T>C	uc001xay.2	+	1	102	c.11T>C	c.(10-12)GTG>GCG	p.V4A	CGRRF1_uc010tra.1_Missense_Mutation_p.V4A|CGRRF1_uc001xaz.2_RNA	NM_006568	NP_006559	Q99675	CGRF1_HUMAN	cell growth regulator with ring finger domain 1	4					cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1																OREG0022692	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CGRRF1	10668	broad.mit.edu	37	14	54989323	54989323	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54989323T>C	uc001xay.2	+						CGRRF1_uc010tra.1_Intron|CGRRF1_uc001xaz.2_Intron	NM_006568	NP_006559			cell growth regulator with ring finger domain 1						cell cycle arrest|negative regulation of cell proliferation|response to stress		zinc ion binding			ovary(1)	1																		---	---	---	---
WDHD1	11169	broad.mit.edu	37	14	55434067	55434067	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55434067G>A	uc001xbm.1	-	17	2187	c.2109C>T	c.(2107-2109)CGC>CGT	p.R703R	WDHD1_uc010aom.1_Silent_p.R220R|WDHD1_uc001xbn.1_Silent_p.R580R	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	703						cytoplasm|nucleoplasm	DNA binding			skin(1)	1																		---	---	---	---
EXOC5	10640	broad.mit.edu	37	14	57675323	57675323	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57675323A>G	uc001xct.2	-	18					EXOC5_uc001xcs.2_3'UTR|EXOC5_uc010trg.1_3'UTR|EXOC5_uc010trh.1_3'UTR	NM_006544	NP_006535			SEC10 protein						exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3																		---	---	---	---
EXOC5	10640	broad.mit.edu	37	14	57700561	57700561	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57700561A>G	uc001xct.2	-	9	1006	c.755T>C	c.(754-756)ATA>ACA	p.I252T	EXOC5_uc001xcs.2_5'Flank|EXOC5_uc010trg.1_Missense_Mutation_p.I197T|EXOC5_uc010trh.1_Missense_Mutation_p.I187T	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	252					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3																		---	---	---	---
NAA30	122830	broad.mit.edu	37	14	57863507	57863507	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:57863507G>A	uc001xcx.3	+	3	963	c.809G>A	c.(808-810)TGC>TAC	p.C270Y	NAA30_uc010trk.1_Missense_Mutation_p.C12Y|NAA30_uc010aow.2_RNA	NM_001011713	NP_001011713	Q147X3	NAA30_HUMAN	N-acetyltransferase 12	270	N-acetyltransferase.					cytoplasm	peptide alpha-N-acetyltransferase activity			skin(1)	1																		---	---	---	---
SLC35F4	341880	broad.mit.edu	37	14	58056071	58056071	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58056071T>C	uc001xdb.1	-	3	558	c.558A>G	c.(556-558)AAA>AAG	p.K186K	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Silent_p.K27K	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2																		---	---	---	---
DACT1	51339	broad.mit.edu	37	14	59112667	59112667	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59112667C>T	uc001xdw.2	+	4	1490	c.1326C>T	c.(1324-1326)GGC>GGT	p.G442G	DACT1_uc010trv.1_Silent_p.G161G|DACT1_uc001xdx.2_Silent_p.G405G|DACT1_uc010trw.1_Silent_p.G161G	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	442					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5																		---	---	---	---
DAAM1	23002	broad.mit.edu	37	14	59814284	59814284	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59814284A>G	uc001xdz.1	+	18	2258	c.2133A>G	c.(2131-2133)AAA>AAG	p.K711K	DAAM1_uc001xea.1_Silent_p.K701K	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	711	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)														---	---	---	---
GPR135	64582	broad.mit.edu	37	14	59930515	59930515	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59930515G>A	uc010apj.2	-	1	1545	c.1430C>T	c.(1429-1431)CCG>CTG	p.P477L	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	477	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)														---	---	---	---
GPR135	64582	broad.mit.edu	37	14	59930686	59930686	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59930686G>A	uc010apj.2	-	1	1374	c.1259C>T	c.(1258-1260)CCG>CTG	p.P420L	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	420	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)														---	---	---	---
JKAMP	51528	broad.mit.edu	37	14	59961870	59961870	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:59961870A>G	uc001xei.3	+	4	930	c.428A>G	c.(427-429)TAC>TGC	p.Y143C	JKAMP_uc001xef.3_Missense_Mutation_p.Y129C|JKAMP_uc001xeh.3_Missense_Mutation_p.Y123C|JKAMP_uc001xeg.3_Missense_Mutation_p.Y137C|JKAMP_uc010try.1_Missense_Mutation_p.Y66C|JKAMP_uc001xej.3_Missense_Mutation_p.Y66C	NM_001098625	NP_001092095	Q9P055	JKAMP_HUMAN	JNK1-associated membrane protein isoform 2	144	Lumenal (Potential).				ER-associated protein catabolic process|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ubiquitin protein ligase binding			breast(1)	1																		---	---	---	---
RTN1	6252	broad.mit.edu	37	14	60212668	60212668	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60212668G>A	uc001xen.1	-	2	982	c.773C>T	c.(772-774)TCC>TTC	p.S258F		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	258					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)														---	---	---	---
SIX4	51804	broad.mit.edu	37	14	61186582	61186582	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61186582C>A	uc001xfc.2	-	2	1445	c.1445G>T	c.(1444-1446)GGC>GTC	p.G482V	SIX4_uc010app.1_Missense_Mutation_p.G474V	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	482						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)														---	---	---	---
HIF1A	3091	broad.mit.edu	37	14	62188501	62188501	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:62188501T>C	uc001xfq.2	+	4	821	c.417T>C	c.(415-417)TGT>TGC	p.C139C	HIF1A_uc010tsc.1_Silent_p.C56C|HIF1A_uc001xfr.2_Silent_p.C139C|HIF1A_uc001xfs.2_Silent_p.C140C	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	139	Interaction with TSGA10 (By similarity).|PAS 1.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64591849	64591849	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64591849A>G	uc001xgm.2	+	71	13705	c.13475A>G	c.(13474-13476)TAC>TGC	p.Y4492C	SYNE2_uc001xgl.2_Missense_Mutation_p.Y4492C|SYNE2_uc010apy.2_Missense_Mutation_p.Y877C|SYNE2_uc010apz.1_Missense_Mutation_p.Y384C	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4492	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
ZBTB1	22890	broad.mit.edu	37	14	64988891	64988891	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64988891T>C	uc001xhh.3	+	4	1100	c.669T>C	c.(667-669)TTT>TTC	p.F223F	ZBTB1_uc010aqg.2_Silent_p.F223F|ZBTB1_uc001xhi.2_Silent_p.F223F	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	223	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)														---	---	---	---
SPTB	6710	broad.mit.edu	37	14	65260381	65260381	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65260381T>C	uc001xht.2	-	13	2054	c.2000A>G	c.(1999-2001)AAA>AGA	p.K667R	SPTB_uc001xhr.2_Missense_Mutation_p.K667R|SPTB_uc001xhs.2_Missense_Mutation_p.K667R|SPTB_uc001xhu.2_Missense_Mutation_p.K667R	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	667	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)														---	---	---	---
RAB15	376267	broad.mit.edu	37	14	65418332	65418332	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65418332G>A	uc001xhz.2	-	3	316	c.235C>T	c.(235-237)CGG>TGG	p.R79W	FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|RAB15_uc010aqk.2_RNA	NM_198686	NP_941959	P59190	RAB15_HUMAN	RAB15, member RAS onocogene family	79					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)	1				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)														---	---	---	---
ATP6V1D	51382	broad.mit.edu	37	14	67815750	67815750	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67815750T>C	uc001xjf.2	-						ATP6V1D_uc001xje.2_Intron	NM_015994	NP_057078			H(+)-transporting two-sector ATPase						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)														---	---	---	---
ZFYVE26	23503	broad.mit.edu	37	14	68250106	68250106	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68250106T>C	uc001xka.2	-	21	3902	c.3763A>G	c.(3763-3765)ACT>GCT	p.T1255A	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.T1255A	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1255					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)														---	---	---	---
RAD51L1	5890	broad.mit.edu	37	14	68353896	68353896	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68353896A>G	uc001xkf.1	+	7	795	c.731A>G	c.(730-732)TAT>TGT	p.Y244C	RAD51L1_uc010aqq.2_Missense_Mutation_p.Y244C|RAD51L1_uc001xkd.2_Missense_Mutation_p.Y244C|RAD51L1_uc010aqr.2_Missense_Mutation_p.Y125C|RAD51L1_uc001xke.2_Missense_Mutation_p.Y244C|RAD51L1_uc010aqs.1_Missense_Mutation_p.Y244C|RAD51L1_uc001xkg.1_Missense_Mutation_p.Y244C	NM_133509	NP_598193	O15315	RA51B_HUMAN	RAD51-like 1 isoform 3	244					blood coagulation|DNA repair|reciprocal meiotic recombination	nucleoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0				UCEC - Uterine corpus endometrioid carcinoma (185;0.163)|all cancers(60;3.9e-06)|OV - Ovarian serous cystadenocarcinoma(108;0.000103)|BRCA - Breast invasive adenocarcinoma(234;0.000421)				T	HMGA2	lipoma|uterine leiomyoma			Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
SIPA1L1	26037	broad.mit.edu	37	14	72056089	72056089	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72056089T>C	uc001xms.2	+	2	1846	c.1498_splice	c.e2+2	p.E500_splice	SIPA1L1_uc001xmt.2_Splice_Site_p.E500_splice|SIPA1L1_uc001xmu.2_Splice_Site_p.E500_splice|SIPA1L1_uc001xmv.2_Splice_Site_p.E500_splice	NM_015556	NP_056371			signal-induced proliferation-associated 1 like						actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)														---	---	---	---
SIPA1L1	26037	broad.mit.edu	37	14	72200378	72200378	+	Intron	SNP	C	T	T	rs142964544	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72200378C>T	uc001xms.2	+						SIPA1L1_uc001xmt.2_Intron|SIPA1L1_uc001xmu.2_Intron|SIPA1L1_uc001xmv.2_Intron|SIPA1L1_uc010ttm.1_Intron|SIPA1L1_uc001xmw.2_Intron	NM_015556	NP_056371			signal-induced proliferation-associated 1 like						actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)														---	---	---	---
SIPA1L1	26037	broad.mit.edu	37	14	72202057	72202057	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72202057A>G	uc001xms.2	+	20	5483	c.5135A>G	c.(5134-5136)AAC>AGC	p.N1712S	SIPA1L1_uc001xmt.2_Missense_Mutation_p.N1691S|SIPA1L1_uc001xmu.2_Missense_Mutation_p.N1691S|SIPA1L1_uc001xmv.2_Missense_Mutation_p.N1712S|SIPA1L1_uc010ttm.1_Missense_Mutation_p.N1166S|SIPA1L1_uc001xmw.2_Missense_Mutation_p.N477S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1712					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)														---	---	---	---
RGS6	9628	broad.mit.edu	37	14	72985085	72985085	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72985085A>C	uc001xna.3	+	15	1641	c.1118A>C	c.(1117-1119)AAG>ACG	p.K373T	RGS6_uc010ttn.1_Missense_Mutation_p.K373T|RGS6_uc001xmx.3_Missense_Mutation_p.K373T|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.K373T|RGS6_uc010ttp.1_Missense_Mutation_p.K304T|RGS6_uc001xmz.1_Missense_Mutation_p.K234T	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	373	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)														---	---	---	---
RGS6	9628	broad.mit.edu	37	14	73002943	73002943	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73002943G>A	uc001xna.3	+	16	1851	c.1328G>A	c.(1327-1329)CGG>CAG	p.R443Q	RGS6_uc010ttn.1_Missense_Mutation_p.R443Q|RGS6_uc001xmx.3_Missense_Mutation_p.R443Q|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.R443Q|RGS6_uc010ttp.1_Missense_Mutation_p.R374Q|RGS6_uc001xmz.1_Missense_Mutation_p.R304Q	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	443					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)														---	---	---	---
RBM25	58517	broad.mit.edu	37	14	73544179	73544179	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73544179A>G	uc001xno.2	+	4	467	c.259A>G	c.(259-261)ACC>GCC	p.T87A	RBM25_uc001xnn.3_Missense_Mutation_p.T87A|RBM25_uc010ttu.1_Missense_Mutation_p.T87A|RBM25_uc001xnp.2_5'UTR	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	87	RRM.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)														---	---	---	---
PAPLN	89932	broad.mit.edu	37	14	73718794	73718794	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73718794C>T	uc010ttx.1	+	9	1075	c.912C>T	c.(910-912)CCC>CCT	p.P304P	PAPLN_uc001xnw.3_Silent_p.P277P|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Silent_p.P304P	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	304	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)														---	---	---	---
PAPLN	89932	broad.mit.edu	37	14	73729153	73729153	+	Missense_Mutation	SNP	C	T	T	rs150310890	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73729153C>T	uc010ttx.1	+	18	2504	c.2341C>T	c.(2341-2343)CGC>TGC	p.R781C	PAPLN_uc001xnw.3_Missense_Mutation_p.R754C|PAPLN_uc010arl.2_Intron|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.R765C|PAPLN_uc010arm.2_5'UTR|PAPLN_uc010arn.2_5'UTR	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	781	BPTI/Kunitz inhibitor.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)														---	---	---	---
HEATR4	399671	broad.mit.edu	37	14	73967394	73967394	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73967394C>T	uc010tub.1	-	12	2468	c.2146G>A	c.(2146-2148)GCT>ACT	p.A716T	HEATR4_uc010tua.1_Missense_Mutation_p.A669T	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)														---	---	---	---
C14orf43	91748	broad.mit.edu	37	14	74206530	74206530	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74206530G>T	uc001xot.2	-	2	965	c.182C>A	c.(181-183)CCT>CAT	p.P61H	C14orf43_uc001xou.2_Missense_Mutation_p.P61H|C14orf43_uc010tud.1_Missense_Mutation_p.P61H|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	61					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)														---	---	---	---
C14orf45	80127	broad.mit.edu	37	14	74522353	74522353	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74522353A>G	uc010tup.1	+	9	1476	c.1353A>G	c.(1351-1353)CGA>CGG	p.R451R	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	451											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)														---	---	---	---
ABCD4	5826	broad.mit.edu	37	14	74754962	74754962	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74754962A>G	uc001xpr.2	-	16	1659	c.1507T>C	c.(1507-1509)TCC>CCC	p.S503P	ABCD4_uc001xps.2_Missense_Mutation_p.S344P|ABCD4_uc001xpt.2_Missense_Mutation_p.S344P|ABCD4_uc010tur.1_Missense_Mutation_p.S399P	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	503	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)														---	---	---	---
ABCD4	5826	broad.mit.edu	37	14	74757053	74757053	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74757053G>A	uc001xpr.2	-	12	1420	c.1268C>T	c.(1267-1269)ACG>ATG	p.T423M	ABCD4_uc001xps.2_Missense_Mutation_p.T264M|ABCD4_uc001xpt.2_Missense_Mutation_p.T264M|ABCD4_uc010tur.1_Missense_Mutation_p.T319M|ABCD4_uc001xpu.2_Missense_Mutation_p.T160M	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	423	ABC transporter.|ATP (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)												OREG0022800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ABCD4	5826	broad.mit.edu	37	14	74762622	74762622	+	Silent	SNP	G	A	A	rs149779191		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74762622G>A	uc001xpr.2	-	6	755	c.603C>T	c.(601-603)AAC>AAT	p.N201N	ABCD4_uc001xps.2_Silent_p.N42N|ABCD4_uc001xpt.2_Silent_p.N42N|ABCD4_uc010tur.1_Silent_p.N114N|ABCD4_uc001xpu.2_5'UTR|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	201	ABC transmembrane type-1.|Helical; (Potential).					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)														---	---	---	---
YLPM1	56252	broad.mit.edu	37	14	75230218	75230218	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75230218G>A	uc001xqj.3	+	1	150	c.26G>A	c.(25-27)GGC>GAC	p.G9D		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)														---	---	---	---
YLPM1	56252	broad.mit.edu	37	14	75265004	75265004	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75265004C>T	uc001xqj.3	+	5	3128	c.3004C>T	c.(3004-3006)CGG>TGG	p.R1002W	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	807	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)														---	---	---	---
MLH3	27030	broad.mit.edu	37	14	75515935	75515935	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75515935C>T	uc001xrd.1	-	2	640	c.424G>A	c.(424-426)GCT>ACT	p.A142T	MLH3_uc001xre.1_Missense_Mutation_p.A142T|MLH3_uc010tuy.1_RNA	NM_001040108	NP_001035197	Q9UHC1	MLH3_HUMAN	mutL homolog 3 isoform 1	142					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00688)									MMR					---	---	---	---
BATF	10538	broad.mit.edu	37	14	76012903	76012903	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76012903C>T	uc001xrr.2	+	3	509	c.267C>T	c.(265-267)CAC>CAT	p.H89H		NM_006399	NP_006390	Q16520	BATF_HUMAN	basic leucine zipper transcription factor,	89						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.028)														---	---	---	---
FLVCR2	55640	broad.mit.edu	37	14	76088483	76088483	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76088483A>G	uc001xrs.2	+	2	1107	c.731A>G	c.(730-732)GAC>GGC	p.D244G	FLVCR2_uc010tvd.1_Missense_Mutation_p.D39G	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	244					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)														---	---	---	---
TGFB3	7043	broad.mit.edu	37	14	76427332	76427332	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76427332G>T	uc001xsc.2	-	6	1870	c.1014C>A	c.(1012-1014)GGC>GGA	p.G338G		NM_003239	NP_003230	P10600	TGFB3_HUMAN	transforming growth factor, beta 3 precursor	338					cell growth|cell-cell junction organization|detection of hypoxia|face morphogenesis|in utero embryonic development|induction of apoptosis|lung alveolus development|mammary gland development|menstrual cycle phase|negative regulation of cell proliferation|negative regulation of DNA replication|negative regulation of macrophage cytokine production|negative regulation of neuron apoptosis|odontogenesis|ossification involved in bone remodeling|palate development|platelet activation|platelet degranulation|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of collagen biosynthetic process|positive regulation of DNA replication|positive regulation of epithelial to mesenchymal transition|positive regulation of filopodium assembly|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|response to progesterone stimulus|salivary gland morphogenesis|transforming growth factor beta receptor signaling pathway	extracellular matrix|platelet alpha granule lumen	growth factor activity|identical protein binding|transforming growth factor beta binding|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0169)														---	---	---	---
C14orf118	55668	broad.mit.edu	37	14	76668165	76668165	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:76668165C>A	uc001xsh.2	+	10	1506	c.1420C>A	c.(1420-1422)CCA>ACA	p.P474T	C14orf118_uc001xsi.2_Missense_Mutation_p.P469T|C14orf118_uc001xsl.2_RNA|C14orf118_uc001xsn.1_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	474										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)														---	---	---	---
POMT2	29954	broad.mit.edu	37	14	77745125	77745125	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77745125A>G	uc001xti.2	-	19	2180	c.1979T>C	c.(1978-1980)GTC>GCC	p.V660A	POMT2_uc001xth.1_Missense_Mutation_p.V358A	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	660	Helical; (Potential).				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)														---	---	---	---
POMT2	29954	broad.mit.edu	37	14	77751306	77751306	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77751306A>G	uc001xti.2	-	14	1764	c.1563T>C	c.(1561-1563)CAT>CAC	p.H521H	POMT2_uc001xth.1_Silent_p.H219H	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	521	MIR 3.				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)														---	---	---	---
VIPAR	63894	broad.mit.edu	37	14	77900221	77900221	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77900221T>C	uc001xtt.1	-	17	1481	c.1143A>G	c.(1141-1143)CGA>CGG	p.R381R	VIPAR_uc001xtu.1_Silent_p.R381R|VIPAR_uc010tvj.1_Silent_p.R332R|VIPAR_uc001xtv.1_Silent_p.R381R	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	381					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1																		---	---	---	---
ISM2	145501	broad.mit.edu	37	14	77951099	77951099	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77951099A>G	uc001xtz.2	-	2	379	c.305T>C	c.(304-306)GTT>GCT	p.V102A	ISM2_uc001xua.2_Missense_Mutation_p.V102A|ISM2_uc001xty.2_Missense_Mutation_p.V14A|ISM2_uc010tvl.1_Missense_Mutation_p.V102A	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	102						extracellular region				skin(1)	1																		---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79432495	79432495	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79432495T>C	uc001xun.2	+	9	1895	c.1404T>C	c.(1402-1404)AAT>AAC	p.N468N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.N593N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	841	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	79432705	79432705	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:79432705T>C	uc001xun.2	+	9	2105	c.1614T>C	c.(1612-1614)AAT>AAC	p.N538N	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.N663N	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	911	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
NRXN3	9369	broad.mit.edu	37	14	80328021	80328021	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:80328021C>T	uc001xun.2	+	17	3391	c.2900C>T	c.(2899-2901)CCG>CTG	p.P967L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.P543L|NRXN3_uc010asw.2_Missense_Mutation_p.P365L|NRXN3_uc001xur.3_Missense_Mutation_p.P338L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1549	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81259277	81259277	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81259277T>C	uc001xux.2	-	13	1558	c.1387A>G	c.(1387-1389)AGT>GGT	p.S463G	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	463	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
TSHR	7253	broad.mit.edu	37	14	81610702	81610702	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81610702A>G	uc001xvd.1	+	10						NM_000369	NP_000360			thyroid stimulating hormone receptor isoform 1						cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						---	---	---	---
GPR65	8477	broad.mit.edu	37	14	88478206	88478206	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88478206A>G	uc001xvv.2	+	2						NM_003608	NP_003599			G protein-coupled receptor 65						actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0																		---	---	---	---
PTPN21	11099	broad.mit.edu	37	14	88946106	88946106	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88946106T>C	uc001xwv.3	-	13	2000	c.1669A>G	c.(1669-1671)ATC>GTC	p.I557V	PTPN21_uc010twc.1_Missense_Mutation_p.I353V	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	557						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4																		---	---	---	---
EML5	161436	broad.mit.edu	37	14	89091363	89091363	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:89091363A>G	uc001xxg.2	-	36	5035	c.4849T>C	c.(4849-4851)TAC>CAC	p.Y1617H	EML5_uc001xxf.2_Missense_Mutation_p.Y404H|EML5_uc001xxh.1_Missense_Mutation_p.Y748H	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1609	WD 24.					cytoplasm|microtubule				ovary(3)	3																		---	---	---	---
PSMC1	5700	broad.mit.edu	37	14	90729796	90729796	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:90729796A>G	uc001xyf.2	+						PSMC1_uc001xyg.2_Intron|PSMC1_uc001xyh.2_Intron|PSMC1_uc010twh.1_Intron	NM_002802	NP_002793			proteasome 26S ATPase subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)														---	---	---	---
FBLN5	10516	broad.mit.edu	37	14	92403440	92403440	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92403440C>T	uc001xzx.3	-	4	703	c.230G>A	c.(229-231)CGA>CAA	p.R77Q	FBLN5_uc010aud.2_Missense_Mutation_p.R82Q|FBLN5_uc010aue.2_Missense_Mutation_p.R118Q	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	77	EGF-like 1; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)																---	---	---	---
TRIP11	9321	broad.mit.edu	37	14	92436177	92436177	+	Missense_Mutation	SNP	G	A	A	rs146953990	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92436177G>A	uc001xzy.2	-	21	6568	c.5780C>T	c.(5779-5781)TCG>TTG	p.S1927L	TRIP11_uc010auf.1_Missense_Mutation_p.S1663L	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1927					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)				T	PDGFRB	AML								---	---	---	---
ATXN3	4287	broad.mit.edu	37	14	92560124	92560124	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92560124T>C	uc001yac.3	-	4	355	c.286A>G	c.(286-288)AGT>GGT	p.S96G	ATXN3_uc010aug.2_Missense_Mutation_p.S81G|ATXN3_uc001yad.3_Missense_Mutation_p.S41G|ATXN3_uc010auh.2_Intron|ATXN3_uc001yae.3_Intron|ATXN3_uc010twl.1_Intron	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	96	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)														---	---	---	---
SLC24A4	123041	broad.mit.edu	37	14	92909143	92909143	+	Missense_Mutation	SNP	G	A	A	rs140536494		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92909143G>A	uc001yak.2	+	6	538	c.514G>A	c.(514-516)GGA>AGA	p.G172R	SLC24A4_uc001yai.2_Missense_Mutation_p.G125R|SLC24A4_uc010twm.1_Missense_Mutation_p.G189R|SLC24A4_uc001yaj.2_Missense_Mutation_p.G172R|SLC24A4_uc010auj.2_Missense_Mutation_p.G80R|SLC24A4_uc010twn.1_5'Flank	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	189	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)														---	---	---	---
GOLGA5	9950	broad.mit.edu	37	14	93282672	93282672	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93282672T>C	uc001yaz.1	+	7	1579	c.1397T>C	c.(1396-1398)ATG>ACG	p.M466T		NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	466	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)				T	RET	papillary thyroid								---	---	---	---
CHGA	1113	broad.mit.edu	37	14	93398722	93398722	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93398722G>A	uc001ybc.3	+	7	1076	c.816G>A	c.(814-816)TCG>TCA	p.S272S	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_Silent_p.S121S	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	272					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	94088327	94088327	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94088327T>C	uc001ybv.1	+	28	4366	c.4283T>C	c.(4282-4284)TTA>TCA	p.L1428S	KIAA1409_uc001ybs.1_Missense_Mutation_p.L1406S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1583						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
FAM181A	90050	broad.mit.edu	37	14	94395058	94395058	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94395058C>T	uc001ybz.1	+	3	920	c.613C>T	c.(613-615)CCA>TCA	p.P205S	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.P143S|FAM181A_uc001yca.1_Missense_Mutation_p.P143S	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	205											0																		---	---	---	---
SERPINA12	145264	broad.mit.edu	37	14	94964479	94964479	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94964479G>A	uc001ydj.2	-	3	1052	c.256C>T	c.(256-258)CTG>TTG	p.L86L		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	86					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)														---	---	---	---
SERPINA12	145264	broad.mit.edu	37	14	94964535	94964535	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:94964535T>C	uc001ydj.2	-	3	996	c.200A>G	c.(199-201)AAC>AGC	p.N67S		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	67					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)														---	---	---	---
BDKRB2	624	broad.mit.edu	37	14	96707338	96707338	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96707338A>G	uc010avm.1	+	3	869	c.673A>G	c.(673-675)AAC>GAC	p.N225D	BDKRB2_uc010avl.1_3'UTR|BDKRB2_uc010twu.1_Missense_Mutation_p.N198D|BDKRB2_uc001yfg.2_Missense_Mutation_p.N225D	NM_000623	NP_000614	P30411	BKRB2_HUMAN	bradykinin receptor B2	225	Helical; Name=5; (Potential).				arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			ovary(3)|breast(1)|kidney(1)	5		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96752298	96752298	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96752298T>C	uc001yfi.2	-	42	6396	c.6031A>G	c.(6031-6033)ATT>GTT	p.I2011V		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	2011										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96811655	96811655	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96811655A>G	uc001yfi.2	-	3	758	c.393T>C	c.(391-393)TGT>TGC	p.C131C		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	131										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
EML1	2009	broad.mit.edu	37	14	100377888	100377888	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100377888A>G	uc001ygs.2	+	13	1538	c.1469A>G	c.(1468-1470)AAC>AGC	p.N490S	EML1_uc010tww.1_Missense_Mutation_p.N478S|EML1_uc001ygq.2_Missense_Mutation_p.N509S|EML1_uc001ygr.2_Missense_Mutation_p.N509S	NM_004434	NP_004425	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1	490	WD 5.					cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)																---	---	---	---
WDR25	79446	broad.mit.edu	37	14	100995488	100995488	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100995488T>C	uc010avx.2	+	6	1449	c.1356T>C	c.(1354-1356)CTT>CTC	p.L452L	WDR25_uc001yhm.2_Silent_p.L444L|WDR25_uc001yhn.2_Silent_p.L452L|WDR25_uc010avy.2_RNA|WDR25_uc001yho.2_Silent_p.L195L	NM_001161476	NP_001154948	Q64LD2	WDR25_HUMAN	WD repeat domain 25	452	WD 5.										0		Melanoma(154;0.212)																---	---	---	---
Unknown	0	broad.mit.edu	37	14	101526089	101526089	+	5'Flank	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101526089C>T	uc010awg.2	+						MIR154_hsa-mir-154|MI0000480_5'Flank|MIR496_hsa-mir-496|MI0003136_5'Flank|uc010awh.1_5'Flank|MIR377_hsa-mir-377|MI0000785_5'Flank					DM004429																														---	---	---	---
DIO3	1735	broad.mit.edu	37	14	102028188	102028188	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102028188C>T	uc010txq.1	+	1	501	c.277C>T	c.(277-279)CAT>TAT	p.H93Y	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	93	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)																---	---	---	---
DYNC1H1	1778	broad.mit.edu	37	14	102442075	102442075	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102442075G>A	uc001yks.2	+	2	447	c.283G>A	c.(283-285)GAA>AAA	p.E95K		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	95	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10																		---	---	---	---
DYNC1H1	1778	broad.mit.edu	37	14	102494083	102494083	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102494083T>C	uc001yks.2	+	47	9340	c.9176T>C	c.(9175-9177)ATC>ACC	p.I3059T		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3059	AAA 4 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10																		---	---	---	---
WDR20	91833	broad.mit.edu	37	14	102675555	102675555	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102675555T>C	uc001ykz.2	+	3	1097	c.1048T>C	c.(1048-1050)TCC>CCC	p.S350P	WDR20_uc001yky.1_Missense_Mutation_p.S93P|WDR20_uc001yla.2_Missense_Mutation_p.S226P|WDR20_uc001ylb.2_Missense_Mutation_p.S289P|WDR20_uc010txu.1_Missense_Mutation_p.S381P|WDR20_uc001ylc.2_Intron|WDR20_uc001yld.2_Missense_Mutation_p.S350P|WDR20_uc001yle.2_Missense_Mutation_p.S289P|WDR20_uc001ylf.2_Missense_Mutation_p.S362P	NM_144574	NP_653175	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20 isoform 2	350	WD 4.										0																OREG0022939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RAGE	5891	broad.mit.edu	37	14	102695953	102695953	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102695953T>C	uc001ylm.2	-	11	1249	c.1023A>G	c.(1021-1023)CGA>CGG	p.R341R	RAGE_uc010txv.1_Silent_p.R311R|RAGE_uc001yln.2_Silent_p.R159R|RAGE_uc001ylh.2_Intron|RAGE_uc001yli.2_RNA|RAGE_uc001yll.2_RNA|RAGE_uc001ylj.2_RNA|RAGE_uc001ylk.2_RNA	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	341					signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
RCOR1	23186	broad.mit.edu	37	14	103187412	103187412	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103187412A>G	uc001ymb.2	+	9	1113	c.1113A>G	c.(1111-1113)CGA>CGG	p.R371R		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	371	Interaction with KDM1A.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1																		---	---	---	---
CDC42BPB	9578	broad.mit.edu	37	14	103404718	103404718	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103404718G>A	uc001ymi.1	-	35	5090	c.4858C>T	c.(4858-4860)CCG>TCG	p.P1620S		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1620					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)														---	---	---	---
CDC42BPB	9578	broad.mit.edu	37	14	103416191	103416191	+	Silent	SNP	G	A	A	rs148759838	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103416191G>A	uc001ymi.1	-	26	3592	c.3360C>T	c.(3358-3360)GTC>GTT	p.V1120V	CDC42BPB_uc001ymj.1_Silent_p.V222V	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1120	PH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)														---	---	---	---
C14orf73	91828	broad.mit.edu	37	14	103566731	103566731	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103566731C>T	uc001ymk.2	+	1	251	c.175C>T	c.(175-177)CGG>TGG	p.R59W		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	59											0		Melanoma(154;0.155)	Epithelial(46;0.221)															---	---	---	---
C14orf73	91828	broad.mit.edu	37	14	103574751	103574751	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103574751T>C	uc001ymk.2	+	10	1949	c.1873T>C	c.(1873-1875)TTG>CTG	p.L625L		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	625											0		Melanoma(154;0.155)	Epithelial(46;0.221)															---	---	---	---
ZFYVE21	79038	broad.mit.edu	37	14	104194125	104194125	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104194125T>C	uc001yoc.2	+	3	266	c.232T>C	c.(232-234)TGC>CGC	p.C78R	ZFYVE21_uc001yod.2_Missense_Mutation_p.C78R	NM_024071	NP_076976	Q9BQ24	ZFY21_HUMAN	zinc finger, FYVE domain containing 21	78	FYVE-type.					cytoplasmic membrane-bounded vesicle|focal adhesion	metal ion binding				0		Melanoma(154;0.226)		Epithelial(152;0.245)														---	---	---	---
TDRD9	122402	broad.mit.edu	37	14	104457499	104457499	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104457499A>G	uc001yom.3	+	9	1148	c.1118A>G	c.(1117-1119)AAC>AGC	p.N373S	TDRD9_uc001yon.3_Missense_Mutation_p.N111S	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	373					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)																---	---	---	---
INF2	64423	broad.mit.edu	37	14	105169688	105169688	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105169688C>T	uc001ypb.2	+	4	707	c.564C>T	c.(562-564)AGC>AGT	p.S188S	INF2_uc010tyi.1_Silent_p.S188S|INF2_uc001ypc.2_Silent_p.S188S|INF2_uc001yoy.3_Silent_p.S188S|INF2_uc001ypa.2_Silent_p.S188S	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	188	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)														---	---	---	---
AKT1	207	broad.mit.edu	37	14	105241992	105241992	+	Silent	SNP	G	A	A	rs17846825	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105241992G>A	uc001ypk.2	-	5	986	c.432C>T	c.(430-432)CGC>CGT	p.R144R	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.R144R|AKT1_uc010axa.2_Silent_p.R144R|AKT1_uc001ypm.2_Silent_p.R144R|AKT1_uc001ypn.2_Silent_p.R144R|AKT1_uc010tyk.1_Silent_p.R82R	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	144					activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)		1	Mis		breast|colorectal|ovarian|NSCLC								---	---	---	---
KIAA0284	283638	broad.mit.edu	37	14	105360905	105360905	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105360905G>A	uc010axb.2	+	18	4621	c.4397G>A	c.(4396-4398)CGG>CAG	p.R1466Q	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.R1396Q|KIAA0284_uc001yps.2_Missense_Mutation_p.R1407Q|KIAA0284_uc001ypt.2_Missense_Mutation_p.R134Q	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1501						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)														---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105408451	105408451	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105408451T>A	uc010axc.1	-	7	13457	c.13337A>T	c.(13336-13338)GAG>GTG	p.E4446V	AHNAK2_uc001ypx.2_Missense_Mutation_p.E4346V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4446						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105409652	105409652	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105409652T>C	uc010axc.1	-	7	12256	c.12136A>G	c.(12136-12138)AGC>GGC	p.S4046G	AHNAK2_uc001ypx.2_Missense_Mutation_p.S3946G	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4046						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105409662	105409662	+	Silent	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105409662G>C	uc010axc.1	-	7	12246	c.12126C>G	c.(12124-12126)CCC>CCG	p.P4042P	AHNAK2_uc001ypx.2_Silent_p.P3942P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4042						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105414123	105414123	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105414123A>G	uc010axc.1	-	7	7785	c.7665T>C	c.(7663-7665)CCT>CCC	p.P2555P	AHNAK2_uc001ypx.2_Silent_p.P2455P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2555						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
PACS2	23241	broad.mit.edu	37	14	105843171	105843171	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105843171T>C	uc001yqt.2	+	9	1043	c.868T>C	c.(868-870)TAT>CAT	p.Y290H	PACS2_uc001yqs.2_Missense_Mutation_p.Y215H|PACS2_uc001yqv.2_Missense_Mutation_p.Y290H|PACS2_uc001yqu.2_Missense_Mutation_p.Y290H	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	290					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)														---	---	---	---
MTA1	9112	broad.mit.edu	37	14	105927257	105927257	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105927257T>C	uc001yqx.2	+	10	1096	c.909T>C	c.(907-909)TAT>TAC	p.Y303Y	MTA1_uc001yqy.2_RNA|MTA1_uc001yqz.1_Silent_p.Y217Y|MTA1_uc001yra.1_Silent_p.Y217Y|MTA1_uc001yrb.2_Silent_p.Y64Y	NM_004689	NP_004680	Q13330	MTA1_HUMAN	metastasis associated protein	303	SANT.				signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)														---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106174118	106174118	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106174118C>A	uc010tyt.1	-						uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106236655	106236655	+	RNA	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106236655T>A	uc010tyt.1	-	3614		c.57550A>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysh.1_RNA|uc001ysi.1_RNA					Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106552490	106552490	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106552490T>C	uc010tyt.1	-	1447		c.30345A>G								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106725298	106725298	+	RNA	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106725298C>A	uc010tyt.1	-	588		c.18249G>T								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106757880	106757880	+	RNA	SNP	C	T	T	rs146488407	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106757880C>T	uc010tyt.1	-	472		c.16185G>A								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	106780523	106780523	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:106780523T>C	uc010tyt.1	-	413		c.15339A>G								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
ADAM6	8755	broad.mit.edu	37	14	107114031	107114031	+	RNA	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:107114031C>T	uc010tyt.1	-	84		c.3842G>A								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
OR4M2	390538	broad.mit.edu	37	15	22368607	22368607	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22368607A>G	uc010tzu.1	+	1	32	c.32A>G	c.(31-33)GAA>GGA	p.E11G	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)														---	---	---	---
OR4M2	390538	broad.mit.edu	37	15	22368757	22368757	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22368757T>A	uc010tzu.1	+	1	182	c.182T>A	c.(181-183)TTC>TAC	p.F61Y	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)														---	---	---	---
CYFIP1	23191	broad.mit.edu	37	15	22955229	22955229	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22955229C>T	uc001yus.2	+	15	1727	c.1623C>T	c.(1621-1623)AGC>AGT	p.S541S	CYFIP1_uc001yut.2_Silent_p.S541S|CYFIP1_uc010aya.1_Silent_p.S569S|CYFIP1_uc001yuu.2_5'Flank	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	541					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)														---	---	---	---
NIPA1	123606	broad.mit.edu	37	15	23049143	23049143	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23049143C>T	uc001yvc.2	-	5	701	c.676G>A	c.(676-678)GCC>ACC	p.A226T	NIPA1_uc001yvd.2_Missense_Mutation_p.A56T|NIPA1_uc001yve.2_Missense_Mutation_p.A151T	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	226	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)														---	---	---	---
NIPA1	123606	broad.mit.edu	37	15	23049189	23049189	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23049189C>T	uc001yvc.2	-	5	655	c.630G>A	c.(628-630)GGG>GGA	p.G210G	NIPA1_uc001yvd.2_Silent_p.G40G|NIPA1_uc001yve.2_Silent_p.G135G	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	210	Extracellular (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)														---	---	---	---
NDN	4692	broad.mit.edu	37	15	23932183	23932183	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:23932183G>A	uc001ywk.2	-	1	268	c.182C>T	c.(181-183)CCG>CTG	p.P61L		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	61					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)										Prader-Willi_syndrome				---	---	---	---
C15orf2	23742	broad.mit.edu	37	15	24921511	24921511	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:24921511C>T	uc001ywo.2	+	1	971	c.497C>T	c.(496-498)CCG>CTG	p.P166L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	166					cell differentiation|multicellular organismal development|spermatogenesis			p.P166P(1)		ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)														---	---	---	---
C15orf2	23742	broad.mit.edu	37	15	24922752	24922752	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:24922752A>G	uc001ywo.2	+	1	2212	c.1738A>G	c.(1738-1740)ACT>GCT	p.T580A		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	580					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)														---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25351699	25351699	+	Intron	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25351699T>G	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-28_uc001yxy.2_Intron|IPW_uc001yyb.3_Intron|uc001yyd.2_Intron|SNORD116-29_uc001yyo.2_RNA					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
UBE3A	7337	broad.mit.edu	37	15	25616547	25616547	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25616547T>C	uc001zaq.2	-	4	783	c.783A>G	c.(781-783)GTA>GTG	p.V261V	uc001zae.2_Intron|UBE3A_uc001zar.2_Silent_p.V238V|UBE3A_uc001zas.2_Silent_p.V258V|UBE3A_uc001zat.2_Silent_p.V238V	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	261					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)														---	---	---	---
ATP10A	57194	broad.mit.edu	37	15	25924821	25924821	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25924821G>A	uc010ayu.2	-	21	4273	c.4167C>T	c.(4165-4167)AGC>AGT	p.S1389S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1389	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)														---	---	---	---
ATP10A	57194	broad.mit.edu	37	15	25940269	25940269	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25940269G>C	uc010ayu.2	-	14	2891	c.2785C>G	c.(2785-2787)CAG>GAG	p.Q929E		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	929	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)														---	---	---	---
OCA2	4948	broad.mit.edu	37	15	28235761	28235761	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28235761A>G	uc001zbh.3	-	10	1187	c.1077T>C	c.(1075-1077)GGT>GGC	p.G359G	OCA2_uc010ayv.2_Intron	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	359	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)										Oculocutaneous_Albinism				---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28446623	28446623	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28446623T>C	uc001zbj.2	-	48	7801	c.7695A>G	c.(7693-7695)GTA>GTG	p.V2565V	HERC2_uc001zbk.1_Silent_p.V100V	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2565					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28447538	28447538	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28447538G>C	uc001zbj.2	-	46	7541	c.7435C>G	c.(7435-7437)CTG>GTG	p.L2479V	HERC2_uc001zbk.1_Missense_Mutation_p.L14V	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2479					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28474412	28474412	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28474412T>C	uc001zbj.2	-	34	5307	c.5201A>G	c.(5200-5202)AAG>AGG	p.K1734R		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1734					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28478854	28478854	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28478854A>G	uc001zbj.2	-	28	4413	c.4307T>C	c.(4306-4308)GTC>GCC	p.V1436A		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1436					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
MTMR15	22909	broad.mit.edu	37	15	31197803	31197803	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31197803A>G	uc001zff.2	+	2	1228	c.937A>G	c.(937-939)AAA>GAA	p.K313E	MTMR15_uc001zfc.3_Missense_Mutation_p.K313E|MTMR15_uc010azw.2_Missense_Mutation_p.K313E|MTMR15_uc001zfd.3_Missense_Mutation_p.K313E|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	313					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)									Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
MTMR10	54893	broad.mit.edu	37	15	31247018	31247018	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31247018A>G	uc001zfh.1	-	10	1112	c.1014T>C	c.(1012-1014)AAT>AAC	p.N338N	MTMR10_uc010azx.1_Silent_p.N90N|MTMR10_uc001zfi.1_Silent_p.N90N|MTMR10_uc001zfj.2_Silent_p.N256N|MTMR10_uc001zfk.2_Silent_p.N90N	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	338	Myotubularin phosphatase.						phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)														---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31357227	31357227	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31357227C>T	uc001zfm.2	-						TRPM1_uc010azy.2_Intron|TRPM1_uc001zfl.2_Intron	NM_002420	NP_002411			transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33855130	33855130	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33855130G>A	uc001zhi.2	+	11	1135	c.1065G>A	c.(1063-1065)GTG>GTA	p.V355V	RYR3_uc010bar.2_Silent_p.V355V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	355	Cytoplasmic (By similarity).|MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	33855219	33855219	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:33855219T>C	uc001zhi.2	+						RYR3_uc010bar.2_Intron	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34150099	34150099	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34150099G>A	uc001zhi.2	+	99	14196	c.14126G>A	c.(14125-14127)TGC>TAC	p.C4709Y	RYR3_uc010bar.2_Missense_Mutation_p.C4704Y	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4709				C -> R (in Ref. 6; CAA52326).	cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
SLC12A6	9990	broad.mit.edu	37	15	34529026	34529026	+	Intron	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34529026A>T	uc001zhw.2	-						SLC12A6_uc001zhv.2_Intron|SLC12A6_uc001zhx.2_Intron|SLC12A6_uc001zhy.2_Intron|SLC12A6_uc001zhz.2_Intron|SLC12A6_uc001zia.2_Intron|SLC12A6_uc001zib.2_Intron|SLC12A6_uc001zic.2_Intron|SLC12A6_uc010bau.2_Intron|SLC12A6_uc001zid.2_Intron|SLC12A6_uc001zht.2_Intron|SLC12A6_uc001zhu.2_Intron	NM_133647	NP_598408			solute carrier family 12, member 6 isoform a						angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)													---	---	---	---
LPCAT4	254531	broad.mit.edu	37	15	34657245	34657245	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34657245A>G	uc001zig.2	-	3	536	c.442T>C	c.(442-444)TCC>CCC	p.S148P	LPCAT4_uc010bav.1_Missense_Mutation_p.S148P	NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	148					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0																		---	---	---	---
AQR	9716	broad.mit.edu	37	15	35189126	35189126	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35189126C>T	uc001ziv.2	-	22	2613	c.2432G>A	c.(2431-2433)CGT>CAT	p.R811H		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	811						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
AQR	9716	broad.mit.edu	37	15	35207329	35207329	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35207329T>C	uc001ziv.2	-	16	1575	c.1394A>G	c.(1393-1395)TAC>TGC	p.Y465C		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	465						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)														---	---	---	---
ZNF770	54989	broad.mit.edu	37	15	35275452	35275452	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35275452T>C	uc001ziw.2	-	3	495	c.184A>G	c.(184-186)AAA>GAA	p.K62E		NM_014106	NP_054825	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	62	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)														---	---	---	---
MEIS2	4212	broad.mit.edu	37	15	37385877	37385877	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:37385877T>C	uc001zjr.2	-	6	1581	c.544A>G	c.(544-546)AAA>GAA	p.K182E	MEIS2_uc001zjl.2_Missense_Mutation_p.K169E|MEIS2_uc010ucj.1_Missense_Mutation_p.K169E|MEIS2_uc001zjm.2_Missense_Mutation_p.K94E|MEIS2_uc001zjn.2_Missense_Mutation_p.K36E|MEIS2_uc001zjo.2_Missense_Mutation_p.K182E|MEIS2_uc001zjp.2_Missense_Mutation_p.K182E|MEIS2_uc001zjs.2_Missense_Mutation_p.K182E|MEIS2_uc001zju.2_Missense_Mutation_p.K169E|MEIS2_uc001zjt.2_Missense_Mutation_p.K182E	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	182					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)														---	---	---	---
RASGRP1	10125	broad.mit.edu	37	15	38786879	38786879	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38786879C>T	uc001zke.3	-	16	2141	c.1963G>A	c.(1963-1965)GTG>ATG	p.V655M	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Intron|RASGRP1_uc010bbg.2_Intron|RASGRP1_uc001zkd.3_Missense_Mutation_p.V620M	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	655					cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)														---	---	---	---
C15orf53	400359	broad.mit.edu	37	15	38988843	38988843	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38988843T>C	uc001zkf.1	+	1	45	c.35T>C	c.(34-36)ATT>ACT	p.I12T		NM_207444	NP_997327	Q8NAA6	CO053_HUMAN	hypothetical protein LOC400359	12											0		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)														---	---	---	---
FSIP1	161835	broad.mit.edu	37	15	39893115	39893115	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:39893115G>C	uc001zki.2	-	12	1930	c.1712C>G	c.(1711-1713)ACT>AGT	p.T571S		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	571										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)														---	---	---	---
FSIP1	161835	broad.mit.edu	37	15	40034063	40034063	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40034063A>G	uc001zki.2	-	6	816	c.598T>C	c.(598-600)TTT>CTT	p.F200L		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	200										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)														---	---	---	---
EIF2AK4	440275	broad.mit.edu	37	15	40260054	40260054	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40260054A>G	uc001zkm.1	+	9	1577	c.1527A>G	c.(1525-1527)CCA>CCG	p.P509P	EIF2AK4_uc001zkl.2_Silent_p.P509P|EIF2AK4_uc010bbj.1_Silent_p.P238P	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	509	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)														---	---	---	---
CASC5	57082	broad.mit.edu	37	15	40951543	40951543	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40951543A>G	uc010bbs.1	+	26	6959	c.6798A>G	c.(6796-6798)AGA>AGG	p.R2266R	CASC5_uc010bbt.1_Silent_p.R2240R	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	2266	Necessary for kinetochore localization and for interaction with NSL1 and DSN1.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)														---	---	---	---
INO80	54617	broad.mit.edu	37	15	41276438	41276438	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41276438G>A	uc001zni.2	-	33	4247	c.4034C>T	c.(4033-4035)TCC>TTC	p.S1345F	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1345	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
INO80	54617	broad.mit.edu	37	15	41379768	41379768	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41379768T>C	uc001zni.2	-	6	863	c.650A>G	c.(649-651)AAA>AGA	p.K217R	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	217	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.|Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
TYRO3	7301	broad.mit.edu	37	15	41864656	41864656	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41864656G>A	uc001zof.1	+	15	1993	c.1769G>A	c.(1768-1770)AGC>AAC	p.S590N		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	590	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)														---	---	---	---
TYRO3	7301	broad.mit.edu	37	15	41870425	41870425	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41870425A>G	uc001zof.1	+	19	2848	c.2624A>G	c.(2623-2625)CAG>CGG	p.Q875R		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	875	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)														---	---	---	---
SPTBN5	51332	broad.mit.edu	37	15	42171952	42171952	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42171952C>T	uc001zos.2	-	15	3150	c.2817G>A	c.(2815-2817)CAG>CAA	p.Q939Q		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	974	Spectrin 7.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)														---	---	---	---
TMEM87A	25963	broad.mit.edu	37	15	42512335	42512335	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42512335T>C	uc010udd.1	-	16	1563	c.1404_splice	c.e16-1	p.R468_splice		NM_015497	NP_056312			transmembrane protein 87A isoform 1							integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)														---	---	---	---
CAPN3	825	broad.mit.edu	37	15	42652008	42652008	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42652008C>T	uc001zpn.1	+	1	311	c.5C>T	c.(4-6)CCG>CTG	p.P2L	CAPN3_uc001zpk.1_Intron|CAPN3_uc001zpl.1_Intron|CAPN3_uc010udf.1_Intron|CAPN3_uc010udg.1_Intron|CAPN3_uc001zpo.1_Missense_Mutation_p.P2L|CAPN3_uc001zpp.1_Missense_Mutation_p.P2L	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	2					muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)														---	---	---	---
CAPN3	825	broad.mit.edu	37	15	42693866	42693866	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42693866G>A	uc001zpn.1	+	11	1688	c.1382G>A	c.(1381-1383)CGT>CAT	p.R461H	CAPN3_uc001zpk.1_Missense_Mutation_p.R234H|CAPN3_uc001zpl.1_Missense_Mutation_p.R374H|CAPN3_uc010udf.1_Missense_Mutation_p.R374H|CAPN3_uc010udg.1_Missense_Mutation_p.R326H|CAPN3_uc001zpo.1_Missense_Mutation_p.R461H|CAPN3_uc001zpp.1_Missense_Mutation_p.R413H|CAPN3_uc001zpq.1_5'Flank	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	461	Domain III.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)														---	---	---	---
UBR1	197131	broad.mit.edu	37	15	43244513	43244513	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43244513C>T	uc001zqq.2	-	45	5035	c.4969G>A	c.(4969-4971)GCA>ACA	p.A1657T		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1657					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)														---	---	---	---
UBR1	197131	broad.mit.edu	37	15	43258414	43258414	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43258414G>A	uc001zqq.2	-	41	4594	c.4528C>T	c.(4528-4530)CGC>TGC	p.R1510C		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1510					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)														---	---	---	---
TMEM62	80021	broad.mit.edu	37	15	43441276	43441276	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43441276A>G	uc001zqr.2	+	7	1072	c.793A>G	c.(793-795)ATG>GTG	p.M265V	TMEM62_uc010bda.2_Missense_Mutation_p.M135V	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	265						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)														---	---	---	---
EPB42	2038	broad.mit.edu	37	15	43508513	43508513	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43508513C>T	uc001zra.3	-	2	449	c.149G>A	c.(148-150)CGT>CAT	p.R50H	EPB42_uc010bde.2_Translation_Start_Site|EPB42_uc001zrb.3_Missense_Mutation_p.R80H|EPB42_uc010udm.1_Missense_Mutation_p.R50H	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	50					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)														---	---	---	---
TGM5	9333	broad.mit.edu	37	15	43531051	43531051	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43531051G>A	uc001zrd.1	-	9	1317	c.1309C>T	c.(1309-1311)CGG>TGG	p.R437W	TGM5_uc001zrc.1_Missense_Mutation_p.R94W|TGM5_uc001zre.1_Missense_Mutation_p.R355W	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	437					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)													---	---	---	---
TGM7	116179	broad.mit.edu	37	15	43568758	43568758	+	Silent	SNP	C	T	T	rs143065351		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43568758C>T	uc001zrf.1	-	13	2033	c.2028G>A	c.(2026-2028)CCG>CCA	p.P676P		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	transglutaminase 7	676					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)	2		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)													---	---	---	---
MAP1A	4130	broad.mit.edu	37	15	43817423	43817423	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43817423C>T	uc001zrt.2	+	4	4219	c.3752C>T	c.(3751-3753)GCT>GTT	p.A1251V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1251						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)													---	---	---	---
MAP1A	4130	broad.mit.edu	37	15	43819209	43819209	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43819209G>A	uc001zrt.2	+	4	6005	c.5538G>A	c.(5536-5538)GTG>GTA	p.V1846V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1846						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)													---	---	---	---
MAP1A	4130	broad.mit.edu	37	15	43819857	43819857	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43819857T>C	uc001zrt.2	+	4	6653	c.6186T>C	c.(6184-6186)GTT>GTC	p.V2062V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2062						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)													---	---	---	---
CKMT1A	548596	broad.mit.edu	37	15	43990846	43990846	+	Missense_Mutation	SNP	G	A	A	rs142460452		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43990846G>A	uc001zsn.2	+	9	1411	c.1019G>A	c.(1018-1020)CGC>CAC	p.R340H	CKMT1A_uc010uea.1_Missense_Mutation_p.R371H|CKMT1A_uc001zso.3_Missense_Mutation_p.R340H	NM_001015001	NP_001015001	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A precursor	340	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)													---	---	---	---
ELL3	80237	broad.mit.edu	37	15	44065395	44065395	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44065395A>G	uc001zsw.1	-	11	1516	c.1113T>C	c.(1111-1113)CGT>CGC	p.R371R	ELL3_uc001zsv.1_Silent_p.R325R|ELL3_uc001zsx.1_Silent_p.R255R	NM_025165	NP_079441	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	371					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
WDR76	79968	broad.mit.edu	37	15	44149345	44149345	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44149345A>G	uc001zti.1	+	10	1416	c.1393A>G	c.(1393-1395)ATC>GTC	p.I465V		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	465	WD 4.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)														---	---	---	---
SPG11	80208	broad.mit.edu	37	15	44913997	44913997	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44913997T>C	uc001ztx.2	-	14	2611	c.2580A>G	c.(2578-2580)CTA>CTG	p.L860L	SPG11_uc010ueh.1_Silent_p.L860L|SPG11_uc010uei.1_Silent_p.L860L|SPG11_uc001ztz.1_5'Flank	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	860	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)														---	---	---	---
SPG11	80208	broad.mit.edu	37	15	44914121	44914121	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44914121T>A	uc001ztx.2	-	14	2487	c.2456A>T	c.(2455-2457)AAG>ATG	p.K819M	SPG11_uc010ueh.1_Missense_Mutation_p.K819M|SPG11_uc010uei.1_Missense_Mutation_p.K819M|SPG11_uc001ztz.1_5'Flank	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	819	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)														---	---	---	---
B2M	567	broad.mit.edu	37	15	45007846	45007846	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45007846A>G	uc001zuc.2	+	2	353	c.293A>G	c.(292-294)TAT>TGT	p.Y98C	B2M_uc010uek.1_Missense_Mutation_p.Y98C|B2M_uc010bdx.1_Missense_Mutation_p.M71V	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	98	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)														---	---	---	---
TRIM69	140691	broad.mit.edu	37	15	45050837	45050837	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45050837C>A	uc001zuf.2	+	5	1493	c.598C>A	c.(598-600)CAG>AAG	p.Q200K	TRIM69_uc001zui.1_5'UTR|TRIM69_uc010bdy.1_5'UTR|TRIM69_uc001zug.1_Missense_Mutation_p.Q200K|TRIM69_uc001zuh.1_Missense_Mutation_p.Q41K	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	200	Potential.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)														---	---	---	---
SLC28A2	9153	broad.mit.edu	37	15	45567685	45567685	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45567685T>C	uc001zva.2	+	18	2016	c.1951T>C	c.(1951-1953)TTC>CTC	p.F651L		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	651					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)														---	---	---	---
GATM	2628	broad.mit.edu	37	15	45658660	45658660	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45658660T>C	uc001zvc.2	-	5	1051	c.722A>G	c.(721-723)CAG>CGG	p.Q241R	GATM_uc001zvb.2_Missense_Mutation_p.Q112R|GATM_uc010uev.1_Missense_Mutation_p.Q294R	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	241					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)													---	---	---	---
SPATA5L1	79029	broad.mit.edu	37	15	45702638	45702638	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45702638G>A	uc001zve.2	+	3	1453	c.1344G>A	c.(1342-1344)TCG>TCA	p.S448S	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	448						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)														---	---	---	---
SLC30A4	7782	broad.mit.edu	37	15	45781035	45781035	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45781035T>C	uc001zvj.2	-							NM_013309	NP_037441			solute carrier family 30 (zinc transporter),						regulation of sequestering of zinc ion|response to toxin	endosome membrane|integral to membrane|late endosome	zinc ion transmembrane transporter activity				0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.58e-16)|GBM - Glioblastoma multiforme(94;2.15e-06)														---	---	---	---
SQRDL	58472	broad.mit.edu	37	15	45983161	45983161	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45983161T>C	uc001zvt.2	+						SQRDL_uc001zvu.2_Intron|SQRDL_uc001zvv.2_Intron	NM_021199	NP_067022			sulfide dehydrogenase like precursor								oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)														---	---	---	---
SEMA6D	80031	broad.mit.edu	37	15	48056245	48056245	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48056245T>C	uc010bek.2	+	10	1306	c.946T>C	c.(946-948)TTT>CTT	p.F316L	SEMA6D_uc001zvw.2_Missense_Mutation_p.F316L|SEMA6D_uc001zvx.1_Missense_Mutation_p.F316L|SEMA6D_uc001zvy.2_Missense_Mutation_p.F316L|SEMA6D_uc001zvz.2_Missense_Mutation_p.F316L|SEMA6D_uc001zwa.2_Missense_Mutation_p.F316L|SEMA6D_uc001zwb.2_Missense_Mutation_p.F316L|SEMA6D_uc001zwc.2_Missense_Mutation_p.F316L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	316	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)														---	---	---	---
SLC12A1	6557	broad.mit.edu	37	15	48580325	48580325	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48580325A>G	uc001zwn.3	+	22	2931	c.2715A>G	c.(2713-2715)AAA>AAG	p.K905K	SLC12A1_uc001zwq.3_Silent_p.K676K|SLC12A1_uc001zwr.3_Silent_p.K632K	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	905	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)													---	---	---	---
FBN1	2200	broad.mit.edu	37	15	48707828	48707828	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48707828A>G	uc001zwx.1	-	64	8284	c.7956T>C	c.(7954-7956)TGT>TGC	p.C2652C	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2652	EGF-like 47; calcium-binding.		C -> G (in MFS).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49048376	49048376	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49048376A>G	uc001zwy.2	-	20	3103	c.3069T>C	c.(3067-3069)AGT>AGC	p.S1023S	CEP152_uc001zwz.2_Silent_p.S1023S|CEP152_uc001zxa.1_Silent_p.S930S	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1023					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
CEP152	22995	broad.mit.edu	37	15	49076171	49076171	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49076171G>A	uc001zwy.2	-	10	1354	c.1320C>T	c.(1318-1320)TCC>TCT	p.S440S	CEP152_uc001zwz.2_Silent_p.S440S|CEP152_uc001zxa.1_Silent_p.S347S	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	440	Potential.				centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)														---	---	---	---
C15orf33	196951	broad.mit.edu	37	15	49833967	49833967	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49833967T>C	uc001zxl.2	-	10	1078	c.784A>G	c.(784-786)ACG>GCG	p.T262A	C15orf33_uc001zxm.2_Missense_Mutation_p.T228A	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	262										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)														---	---	---	---
GABPB1	2553	broad.mit.edu	37	15	50578211	50578211	+	Intron	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50578211T>A	uc001zyb.2	-						GABPB1_uc001zya.2_Intron|GABPB1_uc010ufg.1_Intron|GABPB1_uc001zyc.2_3'UTR|GABPB1_uc001zyd.2_3'UTR|GABPB1_uc001zye.2_3'UTR|GABPB1_uc001zyf.2_3'UTR	NM_005254	NP_005245			GA binding protein transcription factor, beta						positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)	1																		---	---	---	---
USP8	9101	broad.mit.edu	37	15	50786480	50786480	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50786480A>G	uc001zym.3	+						USP8_uc001zyl.3_Intron|USP8_uc001zyn.3_Intron|USP8_uc010ufh.1_Intron|uc001zyo.1_RNA|USP8_uc001zyp.3_Intron	NM_001128611	NP_001122083			ubiquitin specific peptidase 8						cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)														---	---	---	---
TRPM7	54822	broad.mit.edu	37	15	50867177	50867177	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50867177A>T	uc001zyt.3	-	34	5155	c.4891T>A	c.(4891-4893)TGT>AGT	p.C1631S	TRPM7_uc001zyr.2_Missense_Mutation_p.C68S	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	1631	Cytoplasmic (Potential).|Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)														---	---	---	---
TRPM7	54822	broad.mit.edu	37	15	50897284	50897284	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50897284A>G	uc001zyt.3	-	21	3031	c.2767T>C	c.(2767-2769)TAC>CAC	p.Y923H	TRPM7_uc010bew.1_Missense_Mutation_p.Y923H|TRPM7_uc001zyu.2_Missense_Mutation_p.Y481H	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	923	Helical; (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)														---	---	---	---
SPPL2A	84888	broad.mit.edu	37	15	51028334	51028334	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51028334A>G	uc001zyv.2	-	8	1076	c.896T>C	c.(895-897)GTA>GCA	p.V299A		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	299	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)														---	---	---	---
TNFAIP8L3	388121	broad.mit.edu	37	15	51350348	51350348	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51350348G>A	uc001zyy.2	-	3	709	c.609C>T	c.(607-609)ACC>ACT	p.T203T		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	203											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)														---	---	---	---
CYP19A1	1588	broad.mit.edu	37	15	51503171	51503171	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51503171G>A	uc001zyz.3	-	11	1597	c.1346C>T	c.(1345-1347)GCC>GTC	p.A449V	CYP19A1_uc001zza.3_Missense_Mutation_p.A449V	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	449					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)													---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51827880	51827880	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51827880A>G	uc002abf.2	-	13	2641	c.2416T>C	c.(2416-2418)TTG>CTG	p.L806L	DMXL2_uc010ufy.1_Silent_p.L806L|DMXL2_uc010bfa.2_Silent_p.L806L	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	806						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
DMXL2	23312	broad.mit.edu	37	15	51857371	51857371	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51857371A>G	uc002abf.2	-						DMXL2_uc010ufy.1_Intron|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078			Dmx-like 2							cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)														---	---	---	---
MYO5A	4644	broad.mit.edu	37	15	52662616	52662616	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52662616T>C	uc002aby.2	-	22	3062	c.2818_splice	c.e22-1	p.N940_splice	MYO5A_uc002abx.3_Splice_Site_p.N940_splice|MYO5A_uc010uge.1_Splice_Site_p.N809_splice	NM_000259	NP_000250			myosin VA isoform 1						actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)														---	---	---	---
MYO5A	4644	broad.mit.edu	37	15	52668673	52668673	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52668673T>C	uc002aby.2	-	19	2535	c.2291A>G	c.(2290-2292)GAC>GGC	p.D764G	MYO5A_uc002abx.3_Missense_Mutation_p.D764G|MYO5A_uc010uge.1_Missense_Mutation_p.D633G	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	764	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)														---	---	---	---
KIAA1370	56204	broad.mit.edu	37	15	52902434	52902434	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52902434G>A	uc002acg.3	-	6	830	c.677C>T	c.(676-678)ACG>ATG	p.T226M	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Missense_Mutation_p.T138M|KIAA1370_uc010ugf.1_Missense_Mutation_p.T233M	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	226											0				all cancers(107;0.0803)														---	---	---	---
ONECUT1	3175	broad.mit.edu	37	15	53049965	53049965	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53049965G>A	uc002aci.1	-	2	1313	c.1185C>T	c.(1183-1185)GTC>GTT	p.V395V		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	395	Homeobox.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)														---	---	---	---
ONECUT1	3175	broad.mit.edu	37	15	53081197	53081197	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53081197T>G	uc002aci.1	-	1	1013	c.885A>C	c.(883-885)AAA>AAC	p.K295N		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	295	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54793148	54793148	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54793148T>A	uc002ack.2	+	20	5273	c.5273T>A	c.(5272-5274)TTA>TAA	p.L1758*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1758	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54803967	54803967	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54803967A>G	uc002ack.2	+	22	5396	c.5396A>G	c.(5395-5397)AAC>AGC	p.N1799S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1799					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
PIGB	9488	broad.mit.edu	37	15	55632864	55632864	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55632864A>G	uc002act.2	+	8	1217	c.901A>G	c.(901-903)ACA>GCA	p.T301A	PIGB_uc010ugg.1_Missense_Mutation_p.T106A	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	301					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55652756	55652756	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55652756A>G	uc002acv.1	-	8	1380	c.1215T>C	c.(1213-1215)GGT>GGC	p.G405G	CCPG1_uc002acy.2_Silent_p.G405G|CCPG1_uc002acu.1_Silent_p.G261G|CCPG1_uc002acw.1_Silent_p.G130G|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Silent_p.G405G|CCPG1_uc002acz.1_Silent_p.G405G	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	405	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
MIR628	693213	broad.mit.edu	37	15	55665187	55665187	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55665187A>G	hsa-mir-628|MI0003642	-			c.46A>G			CCPG1_uc002acy.2_Intron|CCPG1_uc002acu.1_5'Flank|CCPG1_uc002acw.1_Intron|CCPG1_uc002acv.1_Intron|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Intron|CCPG1_uc002acz.1_Intron																	0																		---	---	---	---
PRTG	283659	broad.mit.edu	37	15	55929363	55929363	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55929363T>C	uc002adg.2	-							NM_173814	NP_776175			protogenin precursor						multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)														---	---	---	---
PRTG	283659	broad.mit.edu	37	15	55972312	55972312	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55972312G>A	uc002adg.2	-	6	961	c.913C>T	c.(913-915)CGG>TGG	p.R305W		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	305	Ig-like 3.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56140717	56140717	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56140717A>G	uc002adj.2	-	12	3040	c.2740_splice	c.e12+1	p.N914_splice	NEDD4_uc002adl.2_Splice_Site_p.N495_splice|NEDD4_uc002adi.2_Splice_Site_p.N842_splice|NEDD4_uc010ugj.1_Splice_Site_p.N898_splice|NEDD4_uc010bfm.2_Splice_Site_p.N897_splice|NEDD4_uc002adk.2_Splice_Site	NM_198400	NP_006145			neural precursor cell expressed, developmentally						development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56207860	56207860	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56207860A>G	uc002adj.2	-	1	1470	c.1170T>C	c.(1168-1170)TGT>TGC	p.C390C	NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Silent_p.C390C|NEDD4_uc010ugj.1_Silent_p.C390C|NEDD4_uc010bfm.2_Silent_p.C390C|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	390					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
ZNF280D	54816	broad.mit.edu	37	15	56958612	56958612	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56958612A>G	uc002adu.2	-	16	2192	c.1975T>C	c.(1975-1977)TAT>CAT	p.Y659H	ZNF280D_uc002adv.2_Missense_Mutation_p.Y646H|ZNF280D_uc010bfq.2_Missense_Mutation_p.Y659H|ZNF280D_uc002adw.1_Missense_Mutation_p.Y687H|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)														---	---	---	---
ZNF280D	54816	broad.mit.edu	37	15	56970887	56970887	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56970887A>G	uc002adu.2	-	11	1354	c.1137T>C	c.(1135-1137)AGT>AGC	p.S379S	ZNF280D_uc002adv.2_Silent_p.S366S|ZNF280D_uc010bfq.2_Silent_p.S379S|ZNF280D_uc002adw.1_Silent_p.S407S|ZNF280D_uc010bfr.1_RNA|ZNF280D_uc010bfp.2_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	379	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)														---	---	---	---
SLTM	79811	broad.mit.edu	37	15	59186298	59186298	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59186298C>T	uc002afp.2	-	11	1560	c.1472G>A	c.(1471-1473)AGA>AAA	p.R491K	SLTM_uc002afn.2_Missense_Mutation_p.R60K|SLTM_uc002afo.2_Missense_Mutation_p.R473K|SLTM_uc002afq.2_Missense_Mutation_p.R60K|SLTM_uc010bgd.2_Missense_Mutation_p.R60K	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	491					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
CCNB2	9133	broad.mit.edu	37	15	59417071	59417071	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59417071T>C	uc002afz.2	+	9	1340	c.1192T>C	c.(1192-1194)TCC>CCC	p.S398P	CCNB2_uc010bge.2_Missense_Mutation_p.S270P	NM_004701	NP_004692	O95067	CCNB2_HUMAN	cyclin B2	398					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding				0																		---	---	---	---
FOXB1	27023	broad.mit.edu	37	15	60297214	60297214	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:60297214T>C	uc002agj.1	+	2	531	c.52T>C	c.(52-54)TAC>CAC	p.Y18H	FOXB1_uc010bgh.1_Intron	NM_012182	NP_036314	Q99853	FOXB1_HUMAN	forkhead box B1	18	Fork-head.				axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NARG2	79664	broad.mit.edu	37	15	60724130	60724130	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:60724130T>C	uc002agp.2	-						NARG2_uc002ago.2_Intron	NM_024611	NP_078887			NMDA receptor regulated 2 isoform a							nucleus				ovary(1)|lung(1)	2																		---	---	---	---
NARG2	79664	broad.mit.edu	37	15	60747243	60747243	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:60747243T>C	uc002agp.2	-	8	1137	c.902A>G	c.(901-903)CAG>CGG	p.Q301R	NARG2_uc002ago.2_Missense_Mutation_p.Q164R|NARG2_uc002agq.3_5'Flank|NARG2_uc010bgk.2_Missense_Mutation_p.Q301R|NARG2_uc002agr.1_Missense_Mutation_p.Q301R	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	301						nucleus				ovary(1)|lung(1)	2																		---	---	---	---
HERC1	8925	broad.mit.edu	37	15	63952040	63952040	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:63952040G>A	uc002amp.2	-	47	9467	c.9319C>T	c.(9319-9321)CGC>TGC	p.R3107C		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3107					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19																		---	---	---	---
HERC1	8925	broad.mit.edu	37	15	64048790	64048790	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64048790A>G	uc002amp.2	-	5	1527	c.1379T>C	c.(1378-1380)GTT>GCT	p.V460A	HERC1_uc010uil.1_Intron|HERC1_uc010bgt.1_Missense_Mutation_p.V460A	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	460	WD 1.|RCC1 2.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19																		---	---	---	---
SNX1	6642	broad.mit.edu	37	15	64423957	64423957	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64423957T>C	uc002amv.2	+	11	1123	c.1087T>C	c.(1087-1089)TTG>CTG	p.L363L	SNX1_uc010bgv.2_Silent_p.L77L|SNX1_uc010uio.1_Silent_p.L363L|SNX1_uc002amw.2_Silent_p.L363L|SNX1_uc002amx.2_Silent_p.L298L|SNX1_uc002amy.2_Silent_p.L292L|SNX1_uc010bgw.2_Silent_p.L265L	NM_003099	NP_003090	Q13596	SNX1_HUMAN	sorting nexin 1 isoform a	363	BAR.				cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0																		---	---	---	---
SNX22	79856	broad.mit.edu	37	15	64446206	64446206	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64446206G>A	uc002anc.1	+						SNX22_uc002amz.1_Silent_p.E127E|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_Intron	NM_024798	NP_079074			sorting nexin 22						cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0																OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF609	23060	broad.mit.edu	37	15	64966838	64966838	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64966838G>A	uc002ann.2	+	4	1785	c.1785G>A	c.(1783-1785)GGG>GGA	p.G595G		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	595						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
ZNF609	23060	broad.mit.edu	37	15	64972981	64972981	+	Missense_Mutation	SNP	G	A	A	rs142970708		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64972981G>A	uc002ann.2	+	7	4082	c.4082G>A	c.(4081-4083)CGC>CAC	p.R1361H		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1361						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
PIF1	80119	broad.mit.edu	37	15	65116102	65116102	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65116102G>T	uc002ant.2	-	2	499	c.433C>A	c.(433-435)CGC>AGC	p.R145S	PIF1_uc002anr.2_5'Flank|PIF1_uc002ans.2_5'Flank|PIF1_uc010uiq.1_Missense_Mutation_p.R145S|PIF1_uc002anu.2_Missense_Mutation_p.R145S	NM_025049	NP_079325	Q9H611	PIF1_HUMAN	DNA helicase homolog PIF1	145					negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65983159	65983159	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65983159T>C	uc002aph.2	-	22	4019	c.3641A>G	c.(3640-3642)AAC>AGC	p.N1214S	DENND4A_uc002api.2_Missense_Mutation_p.N1257S|DENND4A_uc002apj.3_Missense_Mutation_p.N1214S	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65994094	65994094	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65994094A>G	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
RAB11A	8766	broad.mit.edu	37	15	66161946	66161946	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66161946A>G	uc002apk.2	+	1	151	c.23A>G	c.(22-24)TAC>TGC	p.Y8C	RAB11A_uc010ujk.1_Missense_Mutation_p.Y8C	NM_004663	NP_004654	P62491	RB11A_HUMAN	Ras-related protein Rab-11A	8					cell cycle|cytokinesis|neuron projection development|plasma membrane to endosome transport|protein localization in plasma membrane|small GTPase mediated signal transduction|vesicle-mediated transport	cleavage furrow|plasma membrane|recycling endosome membrane|trans-Golgi network	GTP binding|GTPase activity|syntaxin binding				0																		---	---	---	---
DIS3L	115752	broad.mit.edu	37	15	66612927	66612927	+	Missense_Mutation	SNP	C	T	T	rs150139050		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66612927C>T	uc010ujm.1	+	9	1198	c.1183C>T	c.(1183-1185)CGC>TGC	p.R395C	DIS3L_uc010ujl.1_Missense_Mutation_p.R25C|DIS3L_uc002app.2_Missense_Mutation_p.R312C|DIS3L_uc002apq.2_Missense_Mutation_p.R395C|DIS3L_uc010bho.2_Missense_Mutation_p.R261C	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	395					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2																		---	---	---	---
RPL4	6124	broad.mit.edu	37	15	66793281	66793281	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66793281A>G	uc002apv.2	-						RPL4_uc010bhr.2_Intron|RPL4_uc002apw.2_Intron|RPL4_uc002apx.2_Intron	NM_000968	NP_000959			ribosomal protein L4						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0																		---	---	---	---
PIAS1	8554	broad.mit.edu	37	15	68438968	68438968	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68438968C>T	uc002aqz.2	+	6	854	c.758C>T	c.(757-759)ACC>ATC	p.T253I	PIAS1_uc010ujx.1_Missense_Mutation_p.T253I	NM_016166	NP_057250	O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	253	PINIT.				androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
CALML4	91860	broad.mit.edu	37	15	68489899	68489899	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68489899G>A	uc002arb.2	-	4	1106	c.372C>T	c.(370-372)GAC>GAT	p.D124D	CALML4_uc002arc.2_Silent_p.D77D|CALML4_uc002ard.2_RNA|CALML4_uc002are.2_RNA|CALML4_uc010bhz.2_Intron	NM_033429	NP_219501	Q96GE6	CALL4_HUMAN	calmodulin-like 4 isoform 1	124	EF-hand 3.						calcium ion binding				0																		---	---	---	---
ITGA11	22801	broad.mit.edu	37	15	68624344	68624344	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68624344T>G	uc002ari.2	-	14	1710	c.1623A>C	c.(1621-1623)CGA>CGC	p.R541R	ITGA11_uc010bib.2_Silent_p.R541R	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	541	FG-GAP 6.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)													---	---	---	---
KIF23	9493	broad.mit.edu	37	15	69732777	69732777	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69732777G>A	uc002asb.2	+	17	2135	c.2018G>A	c.(2017-2019)CGA>CAA	p.R673Q	KIF23_uc002asc.2_Missense_Mutation_p.R673Q|KIF23_uc010bii.2_Missense_Mutation_p.R563Q|KIF23_uc010ukc.1_Missense_Mutation_p.R490Q	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	673					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0																		---	---	---	---
NR2E3	10002	broad.mit.edu	37	15	72105733	72105733	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72105733T>C	uc002ati.2	+	6	942	c.752T>C	c.(751-753)ATC>ACC	p.I251T	NR2E3_uc002ath.1_Missense_Mutation_p.I251T	NM_014249	NP_055064	Q9Y5X4	NR2E3_HUMAN	photoreceptor-specific nuclear receptor isoform	251					phototransduction|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72172055	72172055	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72172055A>G	uc002atl.3	-						MYO9A_uc002atk.2_Intron|MYO9A_uc002atm.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
ARIH1	25820	broad.mit.edu	37	15	72837173	72837173	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72837173A>G	uc002aut.3	+	3	770	c.456A>G	c.(454-456)GGA>GGG	p.G152G		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	152					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
CD276	80381	broad.mit.edu	37	15	73995290	73995290	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73995290A>G	uc002avv.1	+	4	830	c.596A>G	c.(595-597)CAG>CGG	p.Q199R	CD276_uc010bjd.1_Missense_Mutation_p.Q53R|CD276_uc002avu.1_Missense_Mutation_p.Q199R|CD276_uc002avw.1_Intron|CD276_uc010ulb.1_Missense_Mutation_p.Q145R|CD276_uc002avx.2_5'Flank	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	199	Extracellular (Potential).|Ig-like C2-type 1.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1																		---	---	---	---
TBC1D21	161514	broad.mit.edu	37	15	74177337	74177337	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74177337G>A	uc002avz.2	+						TBC1D21_uc010ulc.1_Intron	NM_153356	NP_699187			TBC1 domain family, member 21							intracellular	Rab GTPase activator activity			ovary(2)	2																		---	---	---	---
CCDC33	80125	broad.mit.edu	37	15	74536490	74536490	+	Splice_Site	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74536490G>T	uc002axo.2	+	2	579	c.185_splice	c.e2+1	p.V62_splice		NM_025055	NP_079331			coiled-coil domain containing 33 isoform 1								protein binding			ovary(3)|skin(2)	5																		---	---	---	---
PPCDC	60490	broad.mit.edu	37	15	75336770	75336770	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75336770G>A	uc002azo.2	+	4	388	c.275G>A	c.(274-276)CGG>CAG	p.R92Q		NM_021823	NP_068595	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	92					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity				0																		---	---	---	---
MIR631	693216	broad.mit.edu	37	15	75646009	75646009	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75646009T>C	hsa-mir-631|MI0003645	-			c.18T>C			NEIL1_uc002bad.2_Intron|NEIL1_uc002bae.2_Intron																	0																		---	---	---	---
MAN2C1	4123	broad.mit.edu	37	15	75651057	75651057	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75651057T>C	uc002baf.2	-	19	2251	c.2234A>G	c.(2233-2235)CAC>CGC	p.H745R	MAN2C1_uc002bag.2_Missense_Mutation_p.H745R|MAN2C1_uc002bah.2_Missense_Mutation_p.H762R|MAN2C1_uc010bkk.2_Missense_Mutation_p.H646R	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	745					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0																		---	---	---	---
SCAPER	49855	broad.mit.edu	37	15	77020934	77020934	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77020934A>G	uc002bby.2	-	16	2224	c.2165_splice	c.e16+1	p.R722_splice	SCAPER_uc010bkr.2_Intron|SCAPER_uc002bbx.2_Splice_Site_p.R476_splice|SCAPER_uc002bbz.1_Splice_Site_p.R593_splice|SCAPER_uc002bca.1_Splice_Site_p.R587_splice|SCAPER_uc002bcb.1_Splice_Site_p.R728_splice	NM_020843	NP_065894			S-phase cyclin A-associated protein in the ER							endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3																		---	---	---	---
SGK269	79834	broad.mit.edu	37	15	77472351	77472351	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77472351T>C	uc002bcm.2	-	3	2226	c.1918A>G	c.(1918-1920)ATC>GTC	p.I640V	SGK269_uc002bcn.2_Missense_Mutation_p.I640V	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	640					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)														---	---	---	---
SGK269	79834	broad.mit.edu	37	15	77474003	77474003	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77474003A>G	uc002bcm.2	-	3	574	c.266T>C	c.(265-267)CTT>CCT	p.L89P	SGK269_uc002bcn.2_Missense_Mutation_p.L89P	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	89					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)														---	---	---	---
HMG20A	10363	broad.mit.edu	37	15	77750834	77750834	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77750834A>G	uc002bcr.2	+	3	286	c.85A>G	c.(85-87)ACT>GCT	p.T29A	HMG20A_uc002bcq.1_Missense_Mutation_p.T29A|HMG20A_uc002bcs.2_Missense_Mutation_p.T29A	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	29					chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
IDH3A	3419	broad.mit.edu	37	15	78452550	78452550	+	Splice_Site	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78452550T>A	uc002bdd.2	+	4	316	c.289_splice	c.e4+2	p.G97_splice	IDH3A_uc010umt.1_Splice_Site_p.G97_splice|IDH3A_uc010umu.1_Intron|IDH3A_uc002bde.2_Splice_Site_p.G47_splice|IDH3A_uc010umv.1_Splice_Site_p.G47_splice|IDH3A_uc002bdf.2_Splice_Site|IDH3A_uc002bdg.2_Splice_Site_p.G10_splice	NM_005530	NP_005521			isocitrate dehydrogenase 3 (NAD+) alpha						carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)													---	---	---	---
ACSBG1	23205	broad.mit.edu	37	15	78526705	78526705	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78526705T>C	uc002bdh.2	-						ACSBG1_uc010umw.1_Intron|ACSBG1_uc010umx.1_Intron|ACSBG1_uc010umy.1_Intron	NM_015162	NP_055977			lipidosin						long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1																		---	---	---	---
IREB2	3658	broad.mit.edu	37	15	78732202	78732202	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78732202T>C	uc002bdr.2	+	2	247	c.85T>C	c.(85-87)TCT>CCT	p.S29P	IREB2_uc010unb.1_5'UTR|IREB2_uc002bdq.2_Missense_Mutation_p.S29P	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	29							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)														---	---	---	---
RASGRF1	5923	broad.mit.edu	37	15	79304850	79304850	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79304850T>C	uc002beq.2	-	14	2221	c.1846A>G	c.(1846-1848)AGG>GGG	p.R616G	RASGRF1_uc002bep.2_Intron|RASGRF1_uc010blm.1_Intron|RASGRF1_uc002ber.3_Intron|RASGRF1_uc010unh.1_Intron	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	616					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6																		---	---	---	---
RASGRF1	5923	broad.mit.edu	37	15	79339164	79339164	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79339164G>A	uc002beq.2	-	5	1177	c.802C>T	c.(802-804)CGC>TGC	p.R268C	RASGRF1_uc002bep.2_Missense_Mutation_p.R268C|RASGRF1_uc010blm.1_Missense_Mutation_p.R190C|RASGRF1_uc002ber.3_Missense_Mutation_p.R268C	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	268	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6																		---	---	---	---
KIAA1024	23251	broad.mit.edu	37	15	79748861	79748861	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79748861G>A	uc002bew.1	+	2	447	c.372G>A	c.(370-372)TCG>TCA	p.S124S	KIAA1024_uc010unk.1_Silent_p.S124S	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	124						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
KIAA1024	23251	broad.mit.edu	37	15	79749423	79749423	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79749423T>C	uc002bew.1	+	2	1009	c.934T>C	c.(934-936)TAC>CAC	p.Y312H	KIAA1024_uc010unk.1_Missense_Mutation_p.Y312H	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	312						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
ZFAND6	54469	broad.mit.edu	37	15	80429859	80429859	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:80429859A>G	uc002bfe.1	+	7	827	c.516A>G	c.(514-516)GTA>GTG	p.V172V	ZFAND6_uc002bff.1_Silent_p.V172V|ZFAND6_uc002bfg.1_Silent_p.V160V|ZFAND6_uc002bfh.1_Silent_p.V172V|ZFAND6_uc002bfi.1_Silent_p.V172V	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	172	AN1-type.						DNA binding|zinc ion binding				0																		---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83328679	83328679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83328679G>A	uc010uoh.1	-	25	3193	c.3016C>T	c.(3016-3018)CGG>TGG	p.R1006W	AP3B2_uc010uoi.1_Missense_Mutation_p.R1025W|AP3B2_uc010uoj.1_Missense_Mutation_p.R974W|AP3B2_uc010bmp.2_Missense_Mutation_p.R69W|AP3B2_uc010uog.1_Missense_Mutation_p.R642W	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	1006					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83331564	83331564	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83331564G>A	uc010uoh.1	-	22	2835	c.2658C>T	c.(2656-2658)CCC>CCT	p.P886P	AP3B2_uc010uoi.1_Silent_p.P905P|AP3B2_uc010uoj.1_Silent_p.P854P|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Silent_p.P522P	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	886					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84566740	84566740	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84566740C>A	uc002bjz.3	+	14	1822	c.1598C>A	c.(1597-1599)CCG>CAG	p.P533Q	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.P533Q|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.P533Q	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	533	TSP type-1 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
ZSCAN2	54993	broad.mit.edu	37	15	85164847	85164847	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85164847A>G	uc002bkr.2	+	3	1647	c.1421A>G	c.(1420-1422)TAC>TGC	p.Y474C	ZSCAN2_uc010bmz.1_Missense_Mutation_p.Y472C|ZSCAN2_uc010bna.2_Missense_Mutation_p.Y324C|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	474	C2H2-type 10.				cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)														---	---	---	---
ALPK3	57538	broad.mit.edu	37	15	85411579	85411579	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85411579T>C	uc002ble.2	+	14	5783	c.5616T>C	c.(5614-5616)AGT>AGC	p.S1872S	ALPK3_uc010upc.1_Silent_p.S173S	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1872					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)															---	---	---	---
PDE8A	5151	broad.mit.edu	37	15	85664157	85664157	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85664157A>G	uc002blh.2	+	18	2053	c.1864A>G	c.(1864-1866)ACT>GCT	p.T622A	PDE8A_uc002bli.2_Missense_Mutation_p.T576A|PDE8A_uc010bnc.2_Missense_Mutation_p.T375A|PDE8A_uc010bnd.2_Missense_Mutation_p.T375A|PDE8A_uc002blj.2_Missense_Mutation_p.T242A|PDE8A_uc002blk.2_Missense_Mutation_p.T242A|PDE8A_uc002bll.2_5'UTR	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	622	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)															---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86064750	86064750	+	Missense_Mutation	SNP	G	A	A	rs142964345	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86064750G>A	uc002blv.1	+	3	295	c.125G>A	c.(124-126)CGT>CAT	p.R42H	AKAP13_uc002bls.2_Missense_Mutation_p.R42H|AKAP13_uc002blt.1_Missense_Mutation_p.R42H|AKAP13_uc002blu.1_Missense_Mutation_p.R42H	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	42					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86278223	86278223	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86278223T>C	uc002blv.1	+	31	7453	c.7283T>C	c.(7282-7284)GTG>GCG	p.V2428A	AKAP13_uc002blu.1_Missense_Mutation_p.V2432A|AKAP13_uc002blw.1_Missense_Mutation_p.V893A|AKAP13_uc002blx.1_Missense_Mutation_p.V673A	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2428	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86284281	86284281	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86284281T>C	uc002blv.1	+	35	7783	c.7613T>C	c.(7612-7614)GTG>GCG	p.V2538A	AKAP13_uc002blu.1_Missense_Mutation_p.V2542A|AKAP13_uc002blw.1_Missense_Mutation_p.V1003A|AKAP13_uc002blx.1_Missense_Mutation_p.V783A	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2538	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
HAPLN3	145864	broad.mit.edu	37	15	89421322	89421322	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89421322A>G	uc002bnc.2	-	5	1090	c.962T>C	c.(961-963)GTC>GCC	p.V321A	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.V383A	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	321	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)																	---	---	---	---
RHCG	51458	broad.mit.edu	37	15	90021067	90021067	+	Splice_Site	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90021067C>T	uc002bnz.2	-	6	999	c.975_splice	c.e6+1	p.T325_splice	RHCG_uc002bny.2_Splice_Site_p.T96_splice|RHCG_uc002boa.2_Splice_Site|RHCG_uc010bnq.1_Missense_Mutation_p.V210I	NM_016321	NP_057405			Rh family, C glycoprotein						amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)																	---	---	---	---
RHCG	51458	broad.mit.edu	37	15	90026320	90026320	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90026320A>G	uc002bnz.2	-	3	524	c.500T>C	c.(499-501)TTC>TCC	p.F167S	RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Missense_Mutation_p.F51S	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	167	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)																	---	---	---	---
C15orf42	90381	broad.mit.edu	37	15	90167812	90167812	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90167812A>G	uc002boe.2	+	20	4271	c.4271A>G	c.(4270-4272)CAG>CGG	p.Q1424R	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1424					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)															---	---	---	---
KIF7	374654	broad.mit.edu	37	15	90171867	90171867	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90171867G>A	uc002bof.2	-	19	3892	c.3815C>T	c.(3814-3816)CCG>CTG	p.P1272L	KIF7_uc010upw.1_Missense_Mutation_p.P758L|C15orf42_uc010upv.1_Intron	NM_198525	NP_940927	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1272					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			ovary(2)|lung(1)	3	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)															---	---	---	---
ANPEP	290	broad.mit.edu	37	15	90346959	90346959	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90346959G>T	uc002bop.3	-	8	1648	c.1356C>A	c.(1354-1356)TCC>TCA	p.S452S		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	452	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)													---	---	---	---
SEMA4B	10509	broad.mit.edu	37	15	90766816	90766816	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90766816T>C	uc002boy.2	+	9	1170	c.887T>C	c.(886-888)CTA>CCA	p.L296P	SEMA4B_uc002boz.2_Missense_Mutation_p.L296P|SEMA4B_uc010uqd.1_Missense_Mutation_p.L134P|SEMA4B_uc002bpa.2_Missense_Mutation_p.L134P|SEMA4B_uc010bnv.1_5'UTR	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)															---	---	---	---
NGRN	51335	broad.mit.edu	37	15	90808954	90808954	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90808954A>G	uc002bpf.1	+	1	60	c.10A>G	c.(10-12)ACC>GCC	p.T4A	TTLL13_uc002bpe.1_Intron|NGRN_uc002bpg.1_5'UTR	NM_001033088	NP_001028260	Q9NPE2	NGRN_HUMAN	neugrin	4					neuron differentiation	extracellular region|nucleus				large_intestine(2)|ovary(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)															---	---	---	---
IQGAP1	8826	broad.mit.edu	37	15	90972889	90972889	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90972889A>G	uc002bpl.1	+	4	482	c.381A>G	c.(379-381)GGA>GGG	p.G127G		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	127	CH.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)															---	---	---	---
IQGAP1	8826	broad.mit.edu	37	15	90984789	90984789	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90984789C>T	uc002bpl.1	+	8	802	c.701C>T	c.(700-702)GCC>GTC	p.A234V		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	234					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)															---	---	---	---
FES	2242	broad.mit.edu	37	15	91435964	91435964	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91435964C>T	uc002bpv.2	+	14	1831	c.1735C>T	c.(1735-1737)CGC>TGC	p.R579C	FES_uc010uqj.1_Missense_Mutation_p.R451C|FES_uc010uqk.1_Missense_Mutation_p.R561C|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.R451C|FES_uc002bpx.2_Missense_Mutation_p.R509C|FES_uc002bpy.2_Missense_Mutation_p.R521C	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	579	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)															---	---	---	---
FES	2242	broad.mit.edu	37	15	91437188	91437188	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91437188C>T	uc002bpv.2	+	18	2322	c.2226C>T	c.(2224-2226)GAC>GAT	p.D742D	FES_uc010uqj.1_Silent_p.D614D|FES_uc010uqk.1_Silent_p.D724D|FES_uc002bpw.2_Intron|FES_uc010bny.2_Silent_p.D601D|FES_uc002bpx.2_Silent_p.D672D|FES_uc002bpy.2_Silent_p.D684D	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	742	Protein kinase.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)															---	---	---	---
MAN2A2	4122	broad.mit.edu	37	15	91449168	91449168	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91449168G>A	uc010bnz.2	+	5	744	c.629G>A	c.(628-630)CGC>CAC	p.R210H	MAN2A2_uc010boa.2_Missense_Mutation_p.R252H|MAN2A2_uc002bqc.2_Missense_Mutation_p.R210H|MAN2A2_uc010uql.1_5'Flank|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	210	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)															---	---	---	---
MAN2A2	4122	broad.mit.edu	37	15	91450728	91450728	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91450728A>G	uc010bnz.2	+						MAN2A2_uc010boa.2_Intron|MAN2A2_uc002bqc.2_Intron|MAN2A2_uc010uql.1_Intron|MAN2A2_uc010uqm.1_Intron	NM_006122	NP_006113			mannosidase, alpha, class 2A, member 2						mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)															---	---	---	---
UNC45A	55898	broad.mit.edu	37	15	91493834	91493834	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91493834C>T	uc002bqg.2	+	17	2632	c.2292C>T	c.(2290-2292)AGC>AGT	p.S764S	UNC45A_uc002bqd.2_Silent_p.S749S|UNC45A_uc010uqr.1_Silent_p.S156S|UNC45A_uc002bqi.2_Silent_p.S42S	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	764					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)															---	---	---	---
NR2F2	7026	broad.mit.edu	37	15	96877521	96877521	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:96877521T>C	uc010uri.1	+	2	1883	c.659T>C	c.(658-660)CTC>CCC	p.L220P	NR2F2_uc002btp.2_Missense_Mutation_p.L87P|NR2F2_uc010urj.1_Missense_Mutation_p.L67P|NR2F2_uc010urk.1_Missense_Mutation_p.L67P	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	220	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)															---	---	---	---
C15orf51	196968	broad.mit.edu	37	15	100339850	100339850	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100339850T>C	uc010urx.1	-	4		c.1077A>G			C15orf51_uc010ury.1_RNA|uc002bvp.2_5'Flank|C15orf51_uc010urz.1_RNA|uc002bvq.2_5'Flank|uc002bvt.1_5'Flank	NR_003260				Homo sapiens cDNA FLJ43799 fis, clone TESTI4000288.												0																		---	---	---	---
ADAMTS17	170691	broad.mit.edu	37	15	100589167	100589167	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:100589167C>T	uc002bvv.1	-	18	2565	c.2486G>A	c.(2485-2487)CGG>CAG	p.R829Q		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	829	TSP type-1 2.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)														---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101606897	101606897	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101606897C>T	uc002bwr.2	+	33	6140	c.5821C>T	c.(5821-5823)CGG>TGG	p.R1941W	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1941					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
PCSK6	5046	broad.mit.edu	37	15	101924598	101924598	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101924598A>C	uc002bwy.2	-	11	1657	c.1343T>G	c.(1342-1344)CTG>CGG	p.L448R	PCSK6_uc010bpd.2_Intron|PCSK6_uc010bpe.2_Missense_Mutation_p.L448R|PCSK6_uc002bxa.2_Missense_Mutation_p.L448R|PCSK6_uc002bxb.2_Missense_Mutation_p.L448R|PCSK6_uc002bxc.1_Missense_Mutation_p.L448R|PCSK6_uc002bxd.1_Missense_Mutation_p.L448R|PCSK6_uc002bxe.2_Missense_Mutation_p.L448R|PCSK6_uc002bxg.1_Missense_Mutation_p.L448R|PCSK6_uc002bxf.1_5'Flank	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	448	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
PCSK6	5046	broad.mit.edu	37	15	101933449	101933449	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101933449A>G	uc002bwy.2	-	9	1491	c.1177T>C	c.(1177-1179)TAC>CAC	p.Y393H	PCSK6_uc010bpd.2_Missense_Mutation_p.Y263H|PCSK6_uc010bpe.2_Missense_Mutation_p.Y393H|PCSK6_uc002bxa.2_Missense_Mutation_p.Y393H|PCSK6_uc002bxb.2_Missense_Mutation_p.Y393H|PCSK6_uc002bxc.1_Missense_Mutation_p.Y393H|PCSK6_uc002bxd.1_Missense_Mutation_p.Y393H|PCSK6_uc002bxe.2_Missense_Mutation_p.Y393H|PCSK6_uc002bxg.1_Missense_Mutation_p.Y393H	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	393	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
PCSK6	5046	broad.mit.edu	37	15	101938635	101938635	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101938635G>A	uc002bwy.2	-	8	1284	c.970C>T	c.(970-972)CAG>TAG	p.Q324*	PCSK6_uc010bpd.2_Nonsense_Mutation_p.Q194*|PCSK6_uc010bpe.2_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxa.2_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxb.2_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxc.1_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxd.1_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxe.2_Nonsense_Mutation_p.Q324*|PCSK6_uc002bxg.1_Nonsense_Mutation_p.Q324*	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	324	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
TARSL2	123283	broad.mit.edu	37	15	102197159	102197159	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102197159T>C	uc002bxm.2	-	18	2281	c.2226A>G	c.(2224-2226)CGA>CGG	p.R742R	TARSL2_uc002bxl.2_3'UTR|TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	742					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
OR4F6	390648	broad.mit.edu	37	15	102346378	102346378	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102346378T>C	uc010utr.1	+	1	456	c.456T>C	c.(454-456)GGT>GGC	p.G152G		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)															---	---	---	---
RHBDF1	64285	broad.mit.edu	37	16	108423	108423	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:108423G>A	uc002cfl.3	-	21	2632	c.2484C>T	c.(2482-2484)CGC>CGT	p.R828R		NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	828	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)																---	---	---	---
AXIN1	8312	broad.mit.edu	37	16	364605	364605	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:364605G>A	uc002cgp.1	-	3	1134	c.957C>T	c.(955-957)AAC>AAT	p.N319N	AXIN1_uc002cgq.1_Silent_p.N319N	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	319	Interaction with TP53 (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)																---	---	---	---
TMEM8A	58986	broad.mit.edu	37	16	422601	422601	+	Intron	SNP	G	A	A	rs115759137	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:422601G>A	uc002cgu.3	-						MRPL28_uc010bqu.1_5'Flank|MRPL28_uc002cgr.1_5'Flank|MRPL28_uc002cgs.1_5'Flank|MRPL28_uc002cgt.1_5'Flank|TMEM8A_uc002cgv.3_Intron	NM_021259	NP_067082			transmembrane protein 8 (five membrane-spanning						cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3																		---	---	---	---
RAB11FIP3	9727	broad.mit.edu	37	16	511444	511444	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:511444G>A	uc002chf.2	+	2	1094	c.755G>A	c.(754-756)GGC>GAC	p.G252D		NM_014700	NP_055515	O75154	RFIP3_HUMAN	rab11-family interacting protein 3 isoform 1	252	EF-hand 2.|2 (Potential).				cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding				0		Hepatocellular(16;0.0218)																---	---	---	---
PIGQ	9091	broad.mit.edu	37	16	624580	624580	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:624580T>C	uc002cho.2	+	2	608	c.506T>C	c.(505-507)GTA>GCA	p.V169A	PIGQ_uc010bqw.2_Missense_Mutation_p.V169A|PIGQ_uc002chm.2_Missense_Mutation_p.V169A|PIGQ_uc002chn.2_Missense_Mutation_p.V169A|PIGQ_uc010uui.1_Missense_Mutation_p.V183A	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	169					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)																---	---	---	---
WDR90	197335	broad.mit.edu	37	16	701657	701657	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:701657G>A	uc002cii.1	+	8	804	c.750G>A	c.(748-750)CCG>CCA	p.P250P	WDR90_uc002cig.1_Silent_p.P250P|WDR90_uc002cih.1_Silent_p.P250P|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	250										ovary(1)	1		Hepatocellular(780;0.0218)																---	---	---	---
MSLNL	401827	broad.mit.edu	37	16	825480	825480	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:825480C>T	uc002cjz.1	-	5	1281	c.1281G>A	c.(1279-1281)GCG>GCA	p.A427A		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4																		---	---	---	---
CACNA1H	8912	broad.mit.edu	37	16	1262117	1262117	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1262117C>T	uc002cks.2	+	25	4986	c.4738C>T	c.(4738-4740)CGC>TGC	p.R1580C	CACNA1H_uc002ckt.2_Missense_Mutation_p.R1580C|CACNA1H_uc002cku.2_Missense_Mutation_p.R286C|CACNA1H_uc010brj.2_Missense_Mutation_p.R286C|CACNA1H_uc002ckv.2_Missense_Mutation_p.R286C	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1580	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)													---	---	---	---
TPSG1	25823	broad.mit.edu	37	16	1272025	1272025	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1272025A>G	uc002ckw.2	-	6	731	c.729T>C	c.(727-729)GGT>GGC	p.G243G		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	243	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)																---	---	---	---
BAIAP3	8938	broad.mit.edu	37	16	1394813	1394813	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1394813A>G	uc002clk.1	+	20	1877	c.1877A>G	c.(1876-1878)GAC>GGC	p.D626G	BAIAP3_uc002clj.2_Missense_Mutation_p.D608G|BAIAP3_uc010uuz.1_Missense_Mutation_p.D591G|BAIAP3_uc010uva.1_Missense_Mutation_p.D563G|BAIAP3_uc010uvc.1_Missense_Mutation_p.D555G	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	626					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)																---	---	---	---
IFT140	9742	broad.mit.edu	37	16	1652558	1652558	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1652558G>A	uc002cmb.2	-	4	544	c.182C>T	c.(181-183)CCG>CTG	p.P61L		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	61	WD 2.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)																---	---	---	---
MAPK8IP3	23162	broad.mit.edu	37	16	1797135	1797135	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1797135G>A	uc002cmk.2	+	6	970	c.850G>A	c.(850-852)GCC>ACC	p.A284T	MAPK8IP3_uc002cmj.1_RNA|MAPK8IP3_uc002cml.2_Missense_Mutation_p.A284T|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.A285T	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	284					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
MAPK8IP3	23162	broad.mit.edu	37	16	1812944	1812944	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1812944G>A	uc002cmk.2	+	16	1952	c.1832G>A	c.(1831-1833)CGC>CAC	p.R611H	MAPK8IP3_uc002cml.2_Missense_Mutation_p.R605H|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.R612H	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	611					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
MAPK8IP3	23162	broad.mit.edu	37	16	1818228	1818228	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1818228G>T	uc002cmk.2	+	30	3708	c.3588G>T	c.(3586-3588)GAG>GAT	p.E1196D	MAPK8IP3_uc002cml.2_Missense_Mutation_p.E1190D|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.E1197D	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1196					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
NUBP2	10101	broad.mit.edu	37	16	1836918	1836918	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1836918C>T	uc002cmw.3	+	3	385	c.296C>T	c.(295-297)CCG>CTG	p.P99L	NUBP2_uc002cmx.3_Intron|NUBP2_uc010brx.2_Missense_Mutation_p.P39L	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	99						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0																		---	---	---	---
RPL3L	6123	broad.mit.edu	37	16	1995941	1995941	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1995941A>G	uc002cnh.2	-						SEPX1_uc010uvs.1_5'Flank	NM_005061	NP_005052			ribosomal protein L3-like						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0																		---	---	---	---
RNF151	146310	broad.mit.edu	37	16	2018579	2018579	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2018579C>A	uc002cnt.1	+	4	399	c.391C>A	c.(391-393)CGG>AGG	p.R131R		NM_174903	NP_777563	Q2KHN1	RN151_HUMAN	ring finger protein 151	131	TRAF-type.				cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
ZNF598	90850	broad.mit.edu	37	16	2048327	2048327	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2048327A>G	uc002cof.1	-	14	2636	c.2621T>C	c.(2620-2622)CTC>CCC	p.L874P	ZNF598_uc002coe.1_Missense_Mutation_p.L238P	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	874						intracellular	zinc ion binding			lung(1)|breast(1)	2																		---	---	---	---
PKD1	5310	broad.mit.edu	37	16	2153699	2153699	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2153699G>A	uc002cos.1	-	23	8568	c.8359C>T	c.(8359-8361)CGC>TGC	p.R2787C	PKD1_uc002cot.1_Missense_Mutation_p.R2787C|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2787	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
CASKIN1	57524	broad.mit.edu	37	16	2237034	2237034	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2237034T>A	uc010bsg.1	-	9	907	c.875A>T	c.(874-876)TAT>TTT	p.Y292F		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	292	SH3.				signal transduction	cytoplasm				skin(2)	2																		---	---	---	---
C16orf79	283870	broad.mit.edu	37	16	2259973	2259973	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2259973C>T	uc010bsh.2	-	4	593	c.416G>A	c.(415-417)CGG>CAG	p.R139Q	C16orf79_uc002cpi.1_Missense_Mutation_p.R139Q	NM_182563	NP_872369	Q6PL45	CP079_HUMAN	hypothetical protein LOC283870	139	BRICHOS.					integral to membrane				central_nervous_system(1)	1																		---	---	---	---
E4F1	1877	broad.mit.edu	37	16	2278379	2278379	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2278379A>G	uc002cpm.2	+	2	212	c.164A>G	c.(163-165)GAC>GGC	p.D55G	E4F1_uc010bsi.2_Missense_Mutation_p.D55G|E4F1_uc010bsj.2_Missense_Mutation_p.D55G	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	55	Required for ubiquitin ligase activity.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
ABCA3	21	broad.mit.edu	37	16	2369674	2369674	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2369674A>G	uc002cpy.1	-	8	1493	c.781T>C	c.(781-783)TAC>CAC	p.Y261H	ABCA3_uc010bsk.1_Missense_Mutation_p.Y261H|ABCA3_uc010bsl.1_Missense_Mutation_p.Y261H	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	261	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)																---	---	---	---
NTN3	4917	broad.mit.edu	37	16	2522124	2522124	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2522124G>A	uc002cqj.2	+	1	625	c.422G>A	c.(421-423)GGC>GAC	p.G141D		NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	141	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1																		---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2816641	2816641	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2816641C>T	uc002crk.2	+	11	6661	c.6112C>T	c.(6112-6114)CCA>TCA	p.P2038S	SRRM2_uc002crj.1_Missense_Mutation_p.P1942S|SRRM2_uc002crl.1_Missense_Mutation_p.P2038S|SRRM2_uc010bsu.1_Missense_Mutation_p.P1942S	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2038	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
PKMYT1	9088	broad.mit.edu	37	16	3024084	3024084	+	Silent	SNP	C	T	T	rs141013429		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3024084C>T	uc002csn.2	-	7	1670	c.1227G>A	c.(1225-1227)CCG>CCA	p.P409P	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.P409P|PKMYT1_uc002cso.2_Silent_p.P340P|PKMYT1_uc002csp.2_Silent_p.P400P|PKMYT1_uc002csq.2_Silent_p.P400P|PKMYT1_uc010bsy.1_Silent_p.P400P	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	409	Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1																		---	---	---	---
CLDN9	9080	broad.mit.edu	37	16	3063692	3063692	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3063692A>G	uc010uwo.1	+	1	1236	c.329A>G	c.(328-330)GAC>GGC	p.D110G		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	110	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
CLDN6	9074	broad.mit.edu	37	16	3066025	3066025	+	5'UTR	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3066025C>T	uc002csu.3	-	2						NM_021195	NP_067018			claudin 6						calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
ZSCAN10	84891	broad.mit.edu	37	16	3139421	3139421	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3139421G>A	uc002ctv.1	-	5	1937	c.1849C>T	c.(1849-1851)CGC>TGC	p.R617C	ZSCAN10_uc002cty.1_Missense_Mutation_p.R278C|ZSCAN10_uc002ctw.1_Missense_Mutation_p.R535C|ZSCAN10_uc002ctx.1_Missense_Mutation_p.R545C	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	617	C2H2-type 11.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
MEFV	4210	broad.mit.edu	37	16	3297108	3297108	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3297108C>T	uc002cun.1	-	5	1535	c.1495G>A	c.(1495-1497)GAC>AAC	p.D499N		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	499					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)													---	---	---	---
ZNF75A	7627	broad.mit.edu	37	16	3363138	3363138	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3363138T>C	uc002cut.3	+	4	589	c.63T>C	c.(61-63)GAT>GAC	p.D21D	ZNF75A_uc002cuv.3_Intron	NM_153028	NP_694573	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1																		---	---	---	---
BTBD12	84464	broad.mit.edu	37	16	3640761	3640761	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3640761T>C	uc002cvp.2	-	12	3505	c.2878A>G	c.(2878-2880)AGC>GGC	p.S960G		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	960	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0													Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				---	---	---	---
DNASE1	1773	broad.mit.edu	37	16	3707235	3707235	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3707235A>G	uc002cvr.2	+	7	2704	c.597A>G	c.(595-597)AGA>AGG	p.R199R		NM_005223	NP_005214	P24855	DNAS1_HUMAN	deoxyribonuclease I precursor	199					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity				0		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)								Direct_reversal_of_damage					---	---	---	---
CREBBP	1387	broad.mit.edu	37	16	3828788	3828788	+	Silent	SNP	G	A	A	rs61754522		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3828788G>A	uc002cvv.2	-	9	2058	c.1854C>T	c.(1852-1854)CCC>CCT	p.P618P	CREBBP_uc002cvw.2_Silent_p.P580P	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	618	KIX.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)				T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				---	---	---	---
DNAJA3	9093	broad.mit.edu	37	16	4492327	4492327	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4492327T>C	uc002cwk.2	+	5	714	c.689T>C	c.(688-690)GTG>GCG	p.V230A	DNAJA3_uc002cwl.2_Missense_Mutation_p.V230A|DNAJA3_uc010uxk.1_Missense_Mutation_p.V77A	NM_005147	NP_005138	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	230	CR-type.				activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			ovary(2)|breast(2)	4																		---	---	---	---
NMRAL1	57407	broad.mit.edu	37	16	4513759	4513759	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4513759C>T	uc002cwm.2	-	5	778	c.622G>A	c.(622-624)GTC>ATC	p.V208I	NMRAL1_uc002cwn.2_Missense_Mutation_p.V208I|NMRAL1_uc002cwo.2_Missense_Mutation_p.V208I|NMRAL1_uc002cwp.2_Missense_Mutation_p.V244I	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	208						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1																		---	---	---	---
GLYR1	84656	broad.mit.edu	37	16	4855316	4855316	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4855316A>G	uc002cxx.3	-						ROGDI_uc002cxv.2_5'Flank|ROGDI_uc010bua.2_5'Flank|ROGDI_uc002cxw.2_5'Flank|ROGDI_uc010bub.1_5'Flank|ROGDI_uc010uxu.1_5'Flank|GLYR1_uc002cxy.2_Intron|GLYR1_uc002cxz.1_Intron|GLYR1_uc002cya.2_Intron|GLYR1_uc010uxv.1_Intron	NM_032569	NP_115958			cytokine-like nuclear factor n-pac						pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0																		---	---	---	---
UBN1	29855	broad.mit.edu	37	16	4911013	4911013	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4911013G>A	uc002cyb.2	+	7	1359	c.1020G>A	c.(1018-1020)GGG>GGA	p.G340G	UBN1_uc010uxw.1_Silent_p.G340G|UBN1_uc002cyc.2_Silent_p.G340G	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	340					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
PPL	5493	broad.mit.edu	37	16	4933734	4933734	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4933734C>G	uc002cyd.1	-	22	5012	c.4922G>C	c.(4921-4923)GGC>GCC	p.G1641A		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1641	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
C16orf89	146556	broad.mit.edu	37	16	5094420	5094420	+	3'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5094420T>C	uc010bud.2	-	8					ALG1_uc002cyj.2_Intron|C16orf89_uc002cyk.3_Missense_Mutation_p.I377V	NM_152459	NP_689672			hypothetical protein LOC146556 isoform 1							extracellular region				ovary(1)|skin(1)	2																		---	---	---	---
A2BP1	54715	broad.mit.edu	37	16	7680695	7680695	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:7680695C>T	uc002cys.2	+						A2BP1_uc010buf.1_Intron|A2BP1_uc002cyr.1_Intron|A2BP1_uc002cyt.2_Intron|A2BP1_uc010uxz.1_Intron|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Intron|A2BP1_uc010uyb.1_Intron|A2BP1_uc002cyw.2_Intron|A2BP1_uc002cyy.2_Intron|A2BP1_uc002cyx.2_Intron|A2BP1_uc010uyc.1_Intron	NM_018723	NP_061193			ataxin 2-binding protein 1 isoform 4						mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)														---	---	---	---
CIITA	4261	broad.mit.edu	37	16	11001507	11001507	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11001507C>A	uc002dai.3	+	11	2291	c.2158C>A	c.(2158-2160)CTG>ATG	p.L720M	CIITA_uc002daj.3_Missense_Mutation_p.L721M|CIITA_uc002dak.3_Intron|CIITA_uc002dag.2_Missense_Mutation_p.L720M|CIITA_uc002dah.2_Missense_Mutation_p.L672M|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	720	NACHT.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1								T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								---	---	---	---
SOCS1	8651	broad.mit.edu	37	16	11348957	11348957	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11348957G>A	uc002dar.1	-	2	533	c.379C>T	c.(379-381)CGC>TGC	p.R127C	C16orf75_uc002daq.1_Intron	NM_003745	NP_003736	O15524	SOCS1_HUMAN	suppressor of cytokine signaling 1	127	SH2.				interferon-gamma-mediated signaling pathway|JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|negative regulation of tyrosine phosphorylation of Stat3 protein|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	insulin-like growth factor receptor binding|protein kinase binding|protein kinase inhibitor activity	p.Y64fs*1(1)|p.R127_*212del(1)		haematopoietic_and_lymphoid_tissue(64)|lung(3)|breast(1)|central_nervous_system(1)	69								F|O		Hodgkin Lymphoma|PMBL								---	---	---	---
LITAF	9516	broad.mit.edu	37	16	11647383	11647383	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11647383A>G	uc002daz.2	-						LITAF_uc002dba.2_Intron|LITAF_uc002dbb.2_Intron|LITAF_uc002dbc.2_Intron|LITAF_uc002dbd.2_Intron	NM_004862	NP_004853			lipopolysaccharide-induced TNF-alpha factor						apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|lysosomal membrane	signal transducer activity|WW domain binding			liver(1)	1																		---	---	---	---
ZC3H7A	29066	broad.mit.edu	37	16	11861389	11861389	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11861389T>G	uc002dbk.2	-	12	1604	c.1406A>C	c.(1405-1407)AAG>ACG	p.K469T	ZC3H7A_uc002dbj.2_5'Flank|ZC3H7A_uc002dbl.2_Missense_Mutation_p.K469T|ZC3H7A_uc002dbm.1_Missense_Mutation_p.K379T	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	469						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
ZC3H7A	29066	broad.mit.edu	37	16	11868834	11868834	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11868834A>G	uc002dbk.2	-	7	817	c.619_splice	c.e7+1	p.D207_splice	ZC3H7A_uc002dbl.2_Splice_Site_p.D207_splice|ZC3H7A_uc002dbm.1_Splice_Site_p.D207_splice	NM_014153	NP_054872			zinc finger CCCH-type containing 7A							nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
CPPED1	55313	broad.mit.edu	37	16	12798799	12798799	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:12798799T>C	uc002dca.3	-	3	508	c.397A>G	c.(397-399)ACC>GCC	p.T133A	CPPED1_uc002dcb.3_Intron|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	133							hydrolase activity|metal ion binding				0																		---	---	---	---
MKL2	57496	broad.mit.edu	37	16	14354893	14354893	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14354893A>G	uc010uza.1	+	17	3047	c.2892A>G	c.(2890-2892)CCA>CCG	p.P964P	MKL2_uc002dcg.2_Silent_p.P914P|MKL2_uc002dcj.2_Silent_p.P209P	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	953					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5																		---	---	---	---
NTAN1	123803	broad.mit.edu	37	16	15132496	15132496	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15132496A>G	uc002ddd.2	-	9	693	c.688T>C	c.(688-690)TAC>CAC	p.Y230H	PDXDC1_uc002ddc.2_Intron|NTAN1_uc010uzo.1_Missense_Mutation_p.Y125H	NM_173474	NP_775745	Q96AB6	NTAN1_HUMAN	N-terminal Asn amidase	230						cytoplasm					0																		---	---	---	---
RRN3	54700	broad.mit.edu	37	16	15155702	15155702	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15155702C>T	uc002dde.2	-	18	1923	c.1855G>A	c.(1855-1857)GTG>ATG	p.V619M	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Missense_Mutation_p.V487M|RRN3_uc010uzq.1_Missense_Mutation_p.V589M	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	619	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
KIAA0430	9665	broad.mit.edu	37	16	15725274	15725274	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15725274T>C	uc002ddr.2	-	6	1508	c.1315A>G	c.(1315-1317)ACA>GCA	p.T439A	KIAA0430_uc002ddq.2_Missense_Mutation_p.T438A|KIAA0430_uc010uzv.1_Missense_Mutation_p.T435A|KIAA0430_uc010uzw.1_Missense_Mutation_p.T438A	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	438						peroxisome	nucleotide binding|RNA binding				0																		---	---	---	---
MYH11	4629	broad.mit.edu	37	16	15842010	15842010	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15842010C>T	uc002ddy.2	-	17	2181	c.2074G>A	c.(2074-2076)GCG>ACG	p.A692T	MYH11_uc002ddv.2_Missense_Mutation_p.A699T|MYH11_uc002ddw.2_Missense_Mutation_p.A692T|MYH11_uc002ddx.2_Missense_Mutation_p.A699T|MYH11_uc010bvg.2_Missense_Mutation_p.A524T	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	692	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15								T	CBFB	AML								---	---	---	---
MYH11	4629	broad.mit.edu	37	16	15853509	15853509	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15853509T>C	uc002ddy.2	-	12	1432	c.1325A>G	c.(1324-1326)AAA>AGA	p.K442R	MYH11_uc002ddv.2_Missense_Mutation_p.K449R|MYH11_uc002ddw.2_Missense_Mutation_p.K442R|MYH11_uc002ddx.2_Missense_Mutation_p.K449R|MYH11_uc010bvg.2_Missense_Mutation_p.K274R|MYH11_uc002dea.1_Missense_Mutation_p.K148R	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	442	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15								T	CBFB	AML								---	---	---	---
NOMO3	408050	broad.mit.edu	37	16	16355544	16355544	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:16355544T>C	uc002deq.2	+						NOMO3_uc002dep.2_Intron|NOMO3_uc010bvp.1_Intron	NM_001004067	NP_001004067			nodal modulator 3 precursor							integral to membrane	carbohydrate binding|carboxypeptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)														---	---	---	---
XYLT1	64131	broad.mit.edu	37	16	17211735	17211735	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:17211735T>A	uc002dfa.2	-	11	2410	c.2325A>T	c.(2323-2325)GGA>GGT	p.G775G		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	775	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4																		---	---	---	---
XYLT1	64131	broad.mit.edu	37	16	17292097	17292097	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:17292097T>C	uc002dfa.2	-	5	1346	c.1261A>G	c.(1261-1263)AAC>GAC	p.N421D		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	421	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18859270	18859270	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18859270A>G	uc002dfm.2	-	37	6072	c.5709T>C	c.(5707-5709)AGT>AGC	p.S1903S	SMG1_uc010bwb.2_Silent_p.S1763S|SMG1_uc010bwa.2_Silent_p.S634S|SMG1_uc002dfo.3_Silent_p.S201S	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1903	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18863428	18863428	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18863428A>G	uc002dfm.2	-	33	5376	c.5013T>C	c.(5011-5013)GGT>GGC	p.G1671G	SMG1_uc010bwb.2_Silent_p.G1531G|SMG1_uc010bwa.2_Silent_p.G402G|SMG1_uc002dfo.3_5'Flank	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1671	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
COQ7	10229	broad.mit.edu	37	16	19089418	19089418	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19089418G>A	uc002dfr.2	+	6	652	c.592G>A	c.(592-594)GTC>ATC	p.V198I	COQ7_uc002dfs.2_Missense_Mutation_p.V184I	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	198	2.|2 X approximate tandem repeats.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1																		---	---	---	---
C16orf62	57020	broad.mit.edu	37	16	19613036	19613036	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19613036G>A	uc002dgn.1	+	9	787	c.775G>A	c.(775-777)GTC>ATC	p.V259I	C16orf62_uc002dgo.1_Missense_Mutation_p.V259I|C16orf62_uc002dgp.1_Missense_Mutation_p.V8I|C16orf62_uc010vas.1_Missense_Mutation_p.V133I|C16orf62_uc002dgm.1_Missense_Mutation_p.V259I	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	259						integral to membrane				ovary(1)	1																OREG0023661	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GPRC5B	51704	broad.mit.edu	37	16	19884072	19884072	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19884072G>A	uc002dgt.2	-	2	204	c.96C>T	c.(94-96)AGC>AGT	p.S32S	GPRC5B_uc010vav.1_Silent_p.S58S	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	32	Extracellular (Potential).									lung(1)|breast(1)|skin(1)	3																		---	---	---	---
GP2	2813	broad.mit.edu	37	16	20325983	20325983	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20325983A>G	uc002dgv.2	-	11	1634	c.1551T>C	c.(1549-1551)ACT>ACC	p.T517T	GP2_uc002dgw.2_Silent_p.T514T|GP2_uc002dgx.2_Silent_p.T370T|GP2_uc002dgy.2_Silent_p.T367T	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	517						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4																		---	---	---	---
ACSM2A	123876	broad.mit.edu	37	16	20476828	20476828	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20476828T>C	uc010bwe.2	+						ACSM2A_uc010bwd.1_Intron|ACSM2A_uc010vax.1_Intron|ACSM2A_uc002dhf.3_Intron|ACSM2A_uc002dhg.3_Intron|ACSM2A_uc010vay.1_Intron	NM_001010845	NP_001010845			acyl-CoA synthetase medium-chain family member						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3																		---	---	---	---
ERI2	112479	broad.mit.edu	37	16	20873427	20873427	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20873427A>G	uc002dht.3	-						DCUN1D3_uc002dhz.2_Intron	NM_001142725	NP_001136197			exoribonuclease 2 isoform 1							intracellular	exonuclease activity|nucleic acid binding|zinc ion binding			large_intestine(1)	1																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	20946788	20946788	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20946788G>T	uc010vbe.1	-	61	11879	c.11879C>A	c.(11878-11880)CCC>CAC	p.P3960H	DNAH3_uc010vbd.1_Missense_Mutation_p.P1395H	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3960					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	20966223	20966223	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20966223A>G	uc010vbe.1	-	55	10983	c.10983T>C	c.(10981-10983)TGT>TGC	p.C3661C	DNAH3_uc010vbd.1_Silent_p.C1096C	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3661	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	21117982	21117982	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21117982A>G	uc010vbe.1	-	15	2113	c.2113T>C	c.(2113-2115)TAC>CAC	p.Y705H	DNAH3_uc002die.2_Missense_Mutation_p.Y645H	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	705	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
ZP2	7783	broad.mit.edu	37	16	21209140	21209140	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21209140C>A	uc002dii.2	-	18	2042	c.2042G>T	c.(2041-2043)GGG>GTG	p.G681V	ZP2_uc010bwn.1_Missense_Mutation_p.G711V	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	681	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)														---	---	---	---
ZP2	7783	broad.mit.edu	37	16	21216742	21216742	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21216742A>G	uc002dii.2	-	7	692	c.692T>C	c.(691-693)GTG>GCG	p.V231A	ZP2_uc010bwn.1_Missense_Mutation_p.V270A|ZP2_uc010bwo.2_Missense_Mutation_p.V270A	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	231	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)														---	---	---	---
CRYM	1428	broad.mit.edu	37	16	21288787	21288787	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21288787G>T	uc002dik.2	-	2	374	c.289C>A	c.(289-291)CTA>ATA	p.L97I	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.L55I|CRYM_uc002dim.2_Missense_Mutation_p.L97I	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	97					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)													---	---	---	---
IGSF6	10261	broad.mit.edu	37	16	21654458	21654458	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21654458A>G	uc002djg.1	-	5	656	c.603T>C	c.(601-603)CGT>CGC	p.R201R	uc002diq.3_Intron|METTL9_uc002dje.2_Intron|METTL9_uc002djf.2_Intron	NM_005849	NP_005840	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6 precursor	201	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0				GBM - Glioblastoma multiforme(48;0.066)														---	---	---	---
HS3ST2	9956	broad.mit.edu	37	16	22826085	22826085	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22826085G>A	uc002dli.2	+	1	226	c.154G>A	c.(154-156)GCG>ACG	p.A52T	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	52	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)														---	---	---	---
EARS2	124454	broad.mit.edu	37	16	23540844	23540844	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23540844A>G	uc002dlt.3	-	7	1363	c.1331T>C	c.(1330-1332)GTG>GCG	p.V444A	EARS2_uc002dlr.3_RNA|EARS2_uc002dls.3_RNA|EARS2_uc002dlu.2_Missense_Mutation_p.V444A	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	glutamyl-tRNA synthetase 2 precursor	444					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|glutamate-tRNA ligase activity|RNA binding				0				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)													---	---	---	---
PALB2	79728	broad.mit.edu	37	16	23632760	23632760	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23632760A>G	uc002dlx.1	-	10	3236	c.3036T>C	c.(3034-3036)ACT>ACC	p.T1012T		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1012	Interaction with RAD51 and BRCA2.|WD 4.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)				F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				---	---	---	---
PALB2	79728	broad.mit.edu	37	16	23641278	23641278	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23641278T>C	uc002dlx.1	-	5	2397	c.2197A>G	c.(2197-2199)ACT>GCT	p.T733A		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	733					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)				F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				---	---	---	---
PLK1	5347	broad.mit.edu	37	16	23700987	23700987	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23700987A>G	uc002dlz.1	+	9	1651	c.1598A>G	c.(1597-1599)AAC>AGC	p.N533S		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	533	POLO box 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
ERN2	10595	broad.mit.edu	37	16	23712303	23712303	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23712303A>G	uc002dma.3	-	12	1649	c.1480T>C	c.(1480-1482)TGG>CGG	p.W494R	ERN2_uc010bxp.2_Intron|ERN2_uc010bxq.1_Missense_Mutation_p.W302R	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	446	Helical; (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
RBBP6	5930	broad.mit.edu	37	16	24581291	24581291	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24581291A>G	uc002dmh.2	+	17	4320	c.3280A>G	c.(3280-3282)AAA>GAA	p.K1094E	RBBP6_uc010vcb.1_Missense_Mutation_p.K961E|RBBP6_uc002dmi.2_Missense_Mutation_p.K1060E|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.K927E	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1094	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)														---	---	---	---
NSMCE1	197370	broad.mit.edu	37	16	27246576	27246576	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27246576T>C	uc002doi.1	-	3	279	c.181A>G	c.(181-183)AAC>GAC	p.N61D	NSMCE1_uc002doj.1_RNA	NM_145080	NP_659547	Q8WV22	NSE1_HUMAN	non-SMC element 1 homolog	61					DNA recombination|DNA repair|intracellular signal transduction	nucleus	zinc ion binding				0																OREG0023693	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
IL4R	3566	broad.mit.edu	37	16	27374428	27374428	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27374428T>C	uc002don.2	+	11	1997	c.1755T>C	c.(1753-1755)GGT>GGC	p.G585G	IL4R_uc002dop.3_Silent_p.G570G|IL4R_uc010bxy.2_Silent_p.G585G|IL4R_uc002doo.2_Silent_p.G425G	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	585	Required for IL4-induced gene expression.|Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2																		---	---	---	---
GTF3C1	2975	broad.mit.edu	37	16	27500487	27500487	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27500487C>A	uc002dov.1	-	21	3346	c.3306G>T	c.(3304-3306)GAG>GAT	p.E1102D	GTF3C1_uc002dou.2_Missense_Mutation_p.E1102D	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1102						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5																		---	---	---	---
KIAA0556	23247	broad.mit.edu	37	16	27761462	27761462	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:27761462A>G	uc002dow.2	+	16	3205	c.3181A>G	c.(3181-3183)ACC>GCC	p.T1061A		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	1061										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8																		---	---	---	---
CLN3	1201	broad.mit.edu	37	16	28503056	28503056	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28503056G>A	uc002dpo.2	-	1	348	c.25C>T	c.(25-27)CGG>TGG	p.R9W	uc010vct.1_Intron|CLN3_uc002dpl.2_5'UTR|CLN3_uc010vcu.1_5'UTR|CLN3_uc002dpn.2_Missense_Mutation_p.R9W|CLN3_uc002dpm.2_5'UTR|CLN3_uc010vcv.1_Missense_Mutation_p.R9W|CLN3_uc010byd.2_Missense_Mutation_p.R9W|CLN3_uc002dpp.2_Missense_Mutation_p.R9W|CLN3_uc002dpt.1_5'UTR|CLN3_uc002dpq.1_Missense_Mutation_p.R9W|CLN3_uc010bye.1_Missense_Mutation_p.R9W|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Silent_p.G10G|CLN3_uc002dpu.1_5'UTR|CLN3_uc002dpw.1_5'UTR|CLN3_uc010vcw.1_5'UTR|CLN3_uc002dqa.2_Missense_Mutation_p.R9W|CLN3_uc010vcx.1_5'UTR|CLN3_uc002dpx.1_Missense_Mutation_p.R9W|CLN3_uc002dpy.1_Silent_p.G10G|CLN3_uc002dpz.1_RNA|APOB48R_uc002dqb.1_5'Flank|APOB48R_uc010byg.1_5'Flank	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	9					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0																OREG0023706	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SULT1A2	6799	broad.mit.edu	37	16	28603680	28603680	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28603680T>C	uc002dqg.1	-	7	1030	c.679A>G	c.(679-681)ACG>GCG	p.T227A	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Missense_Mutation_p.T227A	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	227	PAPS (By similarity).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0																		---	---	---	---
MAZ	4150	broad.mit.edu	37	16	29818672	29818672	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29818672C>T	uc002dty.2	+	2	734	c.566C>T	c.(565-567)CCC>CTC	p.P189L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Intron|MAZ_uc010vdx.1_Missense_Mutation_p.P166L|MAZ_uc002dtw.2_Intron|MAZ_uc002dtx.2_Missense_Mutation_p.P189L|MAZ_uc010bzg.2_Intron|MAZ_uc002dtz.1_5'Flank|MAZ_uc002dua.2_5'Flank|MAZ_uc010vdy.1_5'Flank	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	189					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
C16orf53	79447	broad.mit.edu	37	16	29831039	29831039	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29831039C>T	uc002dug.3	+	3	1048	c.729C>T	c.(727-729)TCC>TCT	p.S243S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duh.1_Intron|MVP_uc010bzh.1_5'Flank|MVP_uc010vdz.1_5'Flank|MVP_uc002dui.2_5'Flank|MVP_uc002duj.2_5'Flank	NM_024516	NP_078792	Q9BTK6	PA1_HUMAN	PTIP-associated 1 protein	243											0																		---	---	---	---
MVP	9961	broad.mit.edu	37	16	29848270	29848270	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29848270C>T	uc002dui.2	+	7	984	c.900C>T	c.(898-900)CGC>CGT	p.R300R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010bzh.1_RNA|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Silent_p.R300R|MVP_uc010vea.1_5'UTR	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	300	MVP 6.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
MVP	9961	broad.mit.edu	37	16	29852909	29852909	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29852909G>A	uc002dui.2	+						uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_Intron|MVP_uc002duj.2_Intron|MVP_uc010vea.1_Intron	NM_005115	NP_005106			major vault protein						mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
MVP	9961	broad.mit.edu	37	16	29853294	29853294	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29853294T>C	uc002dui.2	+	10	1579	c.1495T>C	c.(1495-1497)TCC>CCC	p.S499P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.S499P|MVP_uc010vea.1_Missense_Mutation_p.S93P	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	499	MVP 9.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
SEZ6L2	26470	broad.mit.edu	37	16	29884676	29884676	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29884676C>T	uc002duq.3	-	14	2613	c.2373G>A	c.(2371-2373)GCG>GCA	p.A791A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.A721A|SEZ6L2_uc002dur.3_Silent_p.A721A|SEZ6L2_uc002dus.3_Silent_p.A677A|SEZ6L2_uc010vec.1_Silent_p.A791A|SEZ6L2_uc010ved.1_Silent_p.A747A	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	791	Sushi 5.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2																		---	---	---	---
TAOK2	9344	broad.mit.edu	37	16	29999006	29999006	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29999006G>A	uc002dva.1	+	16	4196	c.3413G>A	c.(3412-3414)CGC>CAC	p.R1138H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Intron|TAOK2_uc002dvc.1_Intron|TAOK2_uc010bzm.1_Missense_Mutation_p.R1145H|TAOK2_uc002dvd.1_Missense_Mutation_p.R965H	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	1138					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1																		---	---	---	---
TBX6	6911	broad.mit.edu	37	16	30100530	30100530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30100530G>A	uc010veh.1	-	4	415	c.355C>T	c.(355-357)CGC>TGC	p.R119C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TBX6_uc002dwk.1_Missense_Mutation_p.R119C	NM_004608	NP_004599	O95947	TBX6_HUMAN	T-box 6	119	T-box.				anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
CORO1A	11151	broad.mit.edu	37	16	30199327	30199327	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30199327T>C	uc002dww.2	+	8	1048	c.926T>C	c.(925-927)ATG>ACG	p.M309T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010bzq.2_Missense_Mutation_p.M309T|CORO1A_uc010bzr.2_Missense_Mutation_p.M309T|CORO1A_uc002dwx.2_Missense_Mutation_p.M203T|CORO1A_uc002dwy.1_3'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	309	WD 7.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0																		---	---	---	---
SEPHS2	22928	broad.mit.edu	37	16	30455783	30455783	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30455783A>G	uc010ves.1	-	2	1442	c.1266T>C	c.(1264-1266)GTT>GTC	p.V422V	SEPHS2_uc002dyh.1_Silent_p.V365V|SEPHS2_uc010vet.1_Silent_p.V304V	NM_012248	NP_036380	Q99611	SPS2_HUMAN	selenophosphate synthetase 2	422					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(2)	2																		---	---	---	---
ITGAL	3683	broad.mit.edu	37	16	30507448	30507448	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30507448G>T	uc002dyi.3	+	14	1710	c.1534G>T	c.(1534-1536)GGG>TGG	p.G512W	ITGAL_uc002dyj.3_Missense_Mutation_p.G429W|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	512	FG-GAP 6.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)													---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30723629	30723629	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30723629A>G	uc002dze.1	+	13	2247	c.1862A>G	c.(1861-1863)TAC>TGC	p.Y621C	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.Y478C|SRCAP_uc010bzz.1_Missense_Mutation_p.Y191C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	621					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30734392	30734392	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30734392C>T	uc002dze.1	+	24	4386	c.4001C>T	c.(4000-4002)CCG>CTG	p.P1334L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.P1129L|SRCAP_uc010bzz.1_Missense_Mutation_p.P904L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1334	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
STX1B	112755	broad.mit.edu	37	16	31012272	31012272	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31012272T>G	uc010cad.2	-	4	369	c.257A>C	c.(256-258)AAC>ACC	p.N86T	STX1B_uc010vfd.1_Missense_Mutation_p.N86T	NM_052874	NP_443106	P61266	STX1B_HUMAN	syntaxin 1B	86	Potential.|Cytoplasmic (Potential).				intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity				0																		---	---	---	---
ZNF668	79759	broad.mit.edu	37	16	31073349	31073349	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31073349G>A	uc010caf.2	-	3	1257	c.900C>T	c.(898-900)CGC>CGT	p.R300R	ZNF668_uc002eao.2_Silent_p.R300R	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	300	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4																		---	---	---	---
FUS	2521	broad.mit.edu	37	16	31202336	31202336	+	Silent	SNP	C	T	T	rs112061837		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31202336C>T	uc002ebf.2	+	14	1529	c.1446C>T	c.(1444-1446)GGC>GGT	p.G482G	FUS_uc002ebh.2_Silent_p.G481G|FUS_uc002ebg.2_Silent_p.G277G|FUS_uc002ebi.2_Silent_p.G483G|FUS_uc002ebj.2_Silent_p.G278G	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	482	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)				T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								---	---	---	---
PYDC1	260434	broad.mit.edu	37	16	31228272	31228272	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31228272C>T	uc002ebo.2	-	1	127	c.78G>A	c.(76-78)AAG>AAA	p.K26K	TRIM72_uc002ebn.1_Intron	NM_152901	NP_690865	Q8WXC3	PYDC1_HUMAN	pyrin domain containing 1	26	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding				0																		---	---	---	---
ITGAM	3684	broad.mit.edu	37	16	31288050	31288050	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31288050C>T	uc002ebq.2	+	10	1166	c.1068C>T	c.(1066-1068)AGC>AGT	p.S356S	ITGAM_uc002ebr.2_Silent_p.S356S|ITGAM_uc010cam.1_Silent_p.S7S	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	356	FG-GAP 3.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1																		---	---	---	---
ITGAD	3681	broad.mit.edu	37	16	31422138	31422138	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31422138C>T	uc002ebv.1	+	12	1344	c.1295C>T	c.(1294-1296)GCT>GTT	p.A432V	ITGAD_uc010cap.1_Missense_Mutation_p.A432V	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	432	FG-GAP 4.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1																		---	---	---	---
TGFB1I1	7041	broad.mit.edu	37	16	31488739	31488739	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31488739C>T	uc002ecd.1	+	11	1254	c.1228C>T	c.(1228-1230)CTC>TTC	p.L410F	TGFB1I1_uc002ece.1_Missense_Mutation_p.L393F|TGFB1I1_uc010caq.1_Missense_Mutation_p.L249F	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	410	LIM zinc-binding 4.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0																		---	---	---	---
ABCC12	94160	broad.mit.edu	37	16	48174690	48174690	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48174690G>A	uc002efc.1	-	4	911	c.565C>T	c.(565-567)CGC>TGC	p.R189C	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.R189C|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	189	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)																---	---	---	---
N4BP1	9683	broad.mit.edu	37	16	48576961	48576961	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48576961T>C	uc002efp.2	-	7	2782	c.2545A>G	c.(2545-2547)AGA>GGA	p.R849G		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	849					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)																---	---	---	---
N4BP1	9683	broad.mit.edu	37	16	48580154	48580154	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48580154T>C	uc002efp.2	-	6	2474	c.2237A>G	c.(2236-2238)TAC>TGC	p.Y746C		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	746					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)																---	---	---	---
N4BP1	9683	broad.mit.edu	37	16	48596113	48596113	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48596113T>C	uc002efp.2	-	2	678	c.441A>G	c.(439-441)CTA>CTG	p.L147L		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	147					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)																---	---	---	---
CBLN1	869	broad.mit.edu	37	16	49313496	49313496	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49313496T>C	uc002efq.2	-	3	740	c.401A>G	c.(400-402)AAC>AGC	p.N134S		NM_004352	NP_004343	P23435	CBLN1_HUMAN	cerebellin 1 precursor	134	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).				nervous system development|synaptic transmission	cell junction|extracellular region|synapse					0		all_cancers(37;0.0766)|all_lung(18;0.24)																---	---	---	---
C16orf78	123970	broad.mit.edu	37	16	49430466	49430466	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49430466A>G	uc002efr.2	+	4	570	c.527A>G	c.(526-528)GAC>GGC	p.D176G		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	176										central_nervous_system(1)	1																		---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50112751	50112751	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50112751C>T	uc002efw.2	+	7	1025	c.863C>T	c.(862-864)GCT>GTT	p.A288V	HEATR3_uc002efx.2_Missense_Mutation_p.A202V	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	288							binding			ovary(1)|skin(1)	2																		---	---	---	---
ADCY7	113	broad.mit.edu	37	16	50347896	50347896	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50347896G>A	uc002egd.1	+	22	3047	c.2779G>A	c.(2779-2781)GTG>ATG	p.V927M		NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	927	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)													---	---	---	---
BRD7	29117	broad.mit.edu	37	16	50354660	50354660	+	Missense_Mutation	SNP	C	T	T	rs143187051	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50354660C>T	uc002egf.1	-	15	1593	c.1526G>A	c.(1525-1527)CGT>CAT	p.R509H	BRD7_uc002ege.1_Missense_Mutation_p.R510H	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	509					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)																---	---	---	---
NKD1	85407	broad.mit.edu	37	16	50659415	50659415	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50659415C>T	uc002egg.1	+	6	610	c.386C>T	c.(385-387)TCC>TTC	p.S129F		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	129	Interaction with DVL1, DVL2 and DVL3 (By similarity).				Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)														---	---	---	---
SNX20	124460	broad.mit.edu	37	16	50707743	50707743	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50707743G>A	uc002egk.2	-	4	698	c.525C>T	c.(523-525)CGC>CGT	p.R175R	SNX20_uc010vgp.1_Intron|SNX20_uc002egi.3_Intron	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	175	PX.				cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1																		---	---	---	---
CYLD	1540	broad.mit.edu	37	16	50783754	50783754	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50783754T>C	uc002egp.1	+	4	560	c.145T>C	c.(145-147)TAT>CAT	p.Y49H	CYLD_uc002egn.1_Missense_Mutation_p.Y49H|CYLD_uc002ego.2_Missense_Mutation_p.Y49H|CYLD_uc010cbs.1_Missense_Mutation_p.Y49H|CYLD_uc002egq.1_Missense_Mutation_p.Y49H|CYLD_uc002egr.1_Missense_Mutation_p.Y49H|CYLD_uc002egs.1_Missense_Mutation_p.Y49H	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	49					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)						Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---	---
CYLD	1540	broad.mit.edu	37	16	50788337	50788337	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50788337T>C	uc002egp.1	+	6	1328	c.913_splice	c.e6+2	p.A305_splice	CYLD_uc002egn.1_Splice_Site_p.E305_splice|CYLD_uc002ego.2_Splice_Site_p.E305_splice|CYLD_uc010cbs.1_Splice_Site_p.E305_splice|CYLD_uc002egq.1_Splice_Site_p.E305_splice|CYLD_uc002egr.1_Splice_Site_p.E305_splice|CYLD_uc002egs.1_Splice_Site_p.E305_splice	NM_015247	NP_056062			ubiquitin carboxyl-terminal hydrolase CYLD						cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)						Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51173803	51173803	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51173803T>C	uc010vgs.1	-	2	2361	c.2330A>G	c.(2329-2331)AAC>AGC	p.N777S	SALL1_uc010vgr.1_Missense_Mutation_p.N680S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	777	C2H2-type 5.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
SALL1	6299	broad.mit.edu	37	16	51175096	51175096	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:51175096G>A	uc010vgs.1	-	2	1068	c.1037C>T	c.(1036-1038)GCG>GTG	p.A346V	SALL1_uc010vgr.1_Missense_Mutation_p.A249V|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	346					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)															---	---	---	---
CHD9	80205	broad.mit.edu	37	16	53190246	53190246	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53190246T>C	uc002ehb.2	+	1	409	c.245T>C	c.(244-246)GTT>GCT	p.V82A	CHD9_uc002egy.2_Missense_Mutation_p.V82A|CHD9_uc002egz.1_Missense_Mutation_p.V82A|CHD9_uc002eha.1_Missense_Mutation_p.V82A|CHD9_uc002ehc.2_Missense_Mutation_p.V82A	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	82					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)																---	---	---	---
RPGRIP1L	23322	broad.mit.edu	37	16	53730184	53730184	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53730184T>C	uc002ehp.2	-	3	173	c.109A>G	c.(109-111)AAG>GAG	p.K37E	RPGRIP1L_uc002eho.3_Missense_Mutation_p.K37E|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.K37E|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.K37E|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.K37E|RPGRIP1L_uc002ehq.1_Missense_Mutation_p.K37E|RPGRIP1L_uc010cby.1_Missense_Mutation_p.K37E	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	37					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)																---	---	---	---
IRX5	10265	broad.mit.edu	37	16	54965177	54965177	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54965177T>C	uc002ehv.2	+	1	67	c.67T>C	c.(67-69)TAC>CAC	p.Y23H	uc010vhb.1_5'Flank|uc010vhc.1_5'Flank|uc002ehu.1_5'Flank|IRX5_uc010cca.1_Missense_Mutation_p.Y23H|IRX5_uc002ehw.2_5'Flank	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	23					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0																		---	---	---	---
IRX5	10265	broad.mit.edu	37	16	54966639	54966639	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54966639T>C	uc002ehv.2	+	2	479	c.479T>C	c.(478-480)GTG>GCG	p.V160A	IRX5_uc010cca.1_Missense_Mutation_p.V212A|IRX5_uc002ehw.2_Missense_Mutation_p.V94A	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	160	Homeobox; TALE-type.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0																		---	---	---	---
IRX5	10265	broad.mit.edu	37	16	54967711	54967711	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54967711T>C	uc002ehv.2	+	3	1378	c.1378T>C	c.(1378-1380)TTG>CTG	p.L460L	IRX5_uc002ehw.2_Silent_p.L394L	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	460					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0																		---	---	---	---
AMFR	267	broad.mit.edu	37	16	56396397	56396397	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56396397A>G	uc002eiy.2	-	14					AMFR_uc002eiw.2_RNA|AMFR_uc002eix.2_3'UTR	NM_001144	NP_001135			autocrine motility factor receptor						endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)	2																		---	---	---	---
BBS2	583	broad.mit.edu	37	16	56533690	56533690	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56533690C>T	uc002ejd.2	-	12	1761	c.1527G>A	c.(1525-1527)AGG>AGA	p.R509R	BBS2_uc010ccg.2_3'UTR	NM_031885	NP_114091	Q9BXC9	BBS2_HUMAN	Bardet-Biedl syndrome 2 protein	509					adult behavior|brain morphogenesis|cerebral cortex development|cilium morphogenesis|fat cell differentiation|hippocampus development|melanosome transport|negative regulation of multicellular organism growth|photoreceptor cell maintenance|protein localization to organelle|regulation of cilium beat frequency involved in ciliary motility|sperm axoneme assembly|striatum development	BBSome|cilium membrane|microtubule basal body|motile cilium	protein binding			ovary(1)	1														Bardet-Biedl_syndrome				---	---	---	---
NLRC5	84166	broad.mit.edu	37	16	57059448	57059448	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57059448A>G	uc002ekk.1	+	6	818	c.593A>G	c.(592-594)GAC>GGC	p.D198G	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.D3G|NLRC5_uc002ekl.2_Missense_Mutation_p.D3G|NLRC5_uc002ekm.2_Missense_Mutation_p.D3G|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	198					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)																---	---	---	---
C16orf57	79650	broad.mit.edu	37	16	58036471	58036471	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58036471G>A	uc002emz.2	+	2	270	c.187G>A	c.(187-189)GAC>AAC	p.D63N	ZNF319_uc002emx.1_5'Flank|C16orf57_uc010via.1_Missense_Mutation_p.D63N|C16orf57_uc002emy.2_RNA|C16orf57_uc010vib.1_Missense_Mutation_p.D63N|C16orf57_uc010vic.1_Missense_Mutation_p.D12N	NM_024598	NP_078874	Q9BQ65	CP057_HUMAN	hypothetical protein LOC79650	63											0																		---	---	---	---
PRSS54	221191	broad.mit.edu	37	16	58324986	58324986	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58324986A>G	uc002enf.2	-	4	535	c.140T>C	c.(139-141)TTG>TCG	p.L47S	PRSS54_uc002eng.2_Missense_Mutation_p.L47S|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	47	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3																		---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58555205	58555205	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58555205A>G	uc002env.2	-	48	7227	c.6934T>C	c.(6934-6936)TTG>CTG	p.L2312L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L2307L|CNOT1_uc002ent.2_Silent_p.L250L|CNOT1_uc010vik.1_Silent_p.L1269L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2312					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58559097	58559097	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58559097T>C	uc002env.2	-	46	7063	c.6770A>G	c.(6769-6771)GAC>GGC	p.D2257G	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.D2252G|CNOT1_uc002ent.2_Missense_Mutation_p.D195G|CNOT1_uc010vik.1_Missense_Mutation_p.D1214G	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2257					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58614646	58614646	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58614646A>G	uc002env.2	-	12	1527	c.1234T>C	c.(1234-1236)TCC>CCC	p.S412P	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.S412P|CNOT1_uc002enx.2_Missense_Mutation_p.S412P|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	412					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CDH16	1014	broad.mit.edu	37	16	66943186	66943186	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66943186G>A	uc002eql.2	-	17	2449	c.2376C>T	c.(2374-2376)GGC>GGT	p.G792G	CDH16_uc010cdy.2_Silent_p.G770G|CDH16_uc002eqm.2_Silent_p.G695G	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	792	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)														---	---	---	---
PLEKHG4	25894	broad.mit.edu	37	16	67315670	67315670	+	Missense_Mutation	SNP	C	T	T	rs148286913		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67315670C>T	uc002eso.3	+	6	3470	c.935C>T	c.(934-936)ACG>ATG	p.T312M	PLEKHG4_uc002esp.3_Missense_Mutation_p.T119M|PLEKHG4_uc002esq.3_Missense_Mutation_p.T312M|PLEKHG4_uc010cef.2_Missense_Mutation_p.T312M|PLEKHG4_uc002ess.3_Missense_Mutation_p.T312M|PLEKHG4_uc010ceg.2_Missense_Mutation_p.T231M	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	312					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)														---	---	---	---
PLEKHG4	25894	broad.mit.edu	37	16	67320682	67320682	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67320682C>T	uc002eso.3	+	16	5320	c.2785C>T	c.(2785-2787)CGA>TGA	p.R929*	PLEKHG4_uc002esp.3_Nonsense_Mutation_p.R736*|PLEKHG4_uc002esq.3_Nonsense_Mutation_p.R929*|PLEKHG4_uc010cef.2_Nonsense_Mutation_p.R929*|PLEKHG4_uc002ess.3_Nonsense_Mutation_p.R929*|PLEKHG4_uc010ceg.2_Nonsense_Mutation_p.R848*	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	929	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)														---	---	---	---
HSD11B2	3291	broad.mit.edu	37	16	67470813	67470813	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67470813A>G	uc002etd.2	+	5	1241	c.1125A>G	c.(1123-1125)GCA>GCG	p.A375A		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	375					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)													---	---	---	---
HSD11B2	3291	broad.mit.edu	37	16	67470852	67470852	+	Silent	SNP	C	T	T	rs45578842	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67470852C>T	uc002etd.2	+	5	1280	c.1164C>T	c.(1162-1164)GAC>GAT	p.D388D		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	388					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)													---	---	---	---
CTCF	10664	broad.mit.edu	37	16	67662300	67662300	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67662300A>G	uc002etl.2	+	9	1836	c.1546A>G	c.(1546-1548)ACC>GCC	p.T516A	CTCF_uc010cek.2_Missense_Mutation_p.T188A|CTCF_uc002etm.1_Missense_Mutation_p.T5A	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	516	C2H2-type 9.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)														---	---	---	---
RLTPR	146206	broad.mit.edu	37	16	67683765	67683765	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67683765A>T	uc002etn.2	+	21	2096	c.1976A>T	c.(1975-1977)CAG>CTG	p.Q659L	RLTPR_uc010cel.1_Missense_Mutation_p.Q652L|RLTPR_uc010vjr.1_Missense_Mutation_p.Q623L	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	659	Tropomodulin-like.|LRR 15.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)														---	---	---	---
RLTPR	146206	broad.mit.edu	37	16	67683871	67683871	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67683871G>A	uc002etn.2	+	21	2202	c.2082G>A	c.(2080-2082)CAG>CAA	p.Q694Q	RLTPR_uc010cel.1_Silent_p.Q687Q|RLTPR_uc010vjr.1_Silent_p.Q658Q	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	694										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)														---	---	---	---
ACD	65057	broad.mit.edu	37	16	67694161	67694161	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67694161T>C	uc002etq.3	-	1	558	c.221A>G	c.(220-222)AAC>AGC	p.N74S	ACD_uc002etp.3_Missense_Mutation_p.N74S|ACD_uc002etr.3_Missense_Mutation_p.N74S|ACD_uc010vjt.1_Missense_Mutation_p.N64S|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	74					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)														---	---	---	---
C16orf48	84080	broad.mit.edu	37	16	67697558	67697558	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67697558A>G	uc002etw.1	-	5	1026	c.743_splice	c.e5+1	p.Y248_splice	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|C16orf48_uc002etv.1_Splice_Site_p.Y130_splice|C16orf48_uc010cem.1_Intron	NM_032140	NP_115516			hypothetical protein LOC84080							microtubule cytoskeleton	protein binding				0		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)														---	---	---	---
RANBP10	57610	broad.mit.edu	37	16	67763602	67763602	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67763602A>G	uc002eud.2	-	9	1244	c.1128T>C	c.(1126-1128)AGT>AGC	p.S376S	RANBP10_uc010ceo.2_Silent_p.S147S|RANBP10_uc010vju.1_Silent_p.S320S|RANBP10_uc010vjv.1_Silent_p.S259S|RANBP10_uc010vjw.1_Silent_p.S37S	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	376	Ser-rich.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)														---	---	---	---
NUTF2	10204	broad.mit.edu	37	16	67902272	67902272	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67902272A>G	uc002eup.2	+	3	228	c.129A>G	c.(127-129)GGA>GGG	p.G43G	NUTF2_uc010vkf.1_Silent_p.G43G|NUTF2_uc002euq.3_5'Flank	NM_005796	NP_005787	P61970	NTF2_HUMAN	nuclear transport factor 2	43	NTF2.				protein transport	cytosol|nuclear pore	protein binding|transporter activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00443)|Epithelial(162;0.0199)|all cancers(182;0.129)														---	---	---	---
PSMB10	5699	broad.mit.edu	37	16	67968770	67968770	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67968770C>A	uc002eux.1	-	7	741	c.640G>T	c.(640-642)GCA>TCA	p.A214S		NM_002801	NP_002792	P40306	PSB10_HUMAN	proteasome beta 10 subunit proprotein	214					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|humoral immune response|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)														---	---	---	---
SLC12A4	6560	broad.mit.edu	37	16	67991804	67991804	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67991804A>G	uc002euz.2	-	4	627	c.486T>C	c.(484-486)TGT>TGC	p.C162C	SLC12A4_uc010ceu.2_Silent_p.C156C|SLC12A4_uc010vkh.1_Silent_p.C131C|SLC12A4_uc010vki.1_Silent_p.C162C|SLC12A4_uc010vkj.1_Silent_p.C164C|SLC12A4_uc002eva.2_Silent_p.C162C|SLC12A4_uc002evb.2_Intron|SLC12A4_uc010cew.1_Silent_p.C45C	NM_005072	NP_005063	Q9UP95	S12A4_HUMAN	solute carrier family 12, member 4 isoform a	162	Helical; (Potential).|Poly-Cys.				cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)													---	---	---	---
DUS2L	54920	broad.mit.edu	37	16	68110607	68110607	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68110607G>A	uc002evi.2	+	15	1304	c.1155G>A	c.(1153-1155)CAG>CAA	p.Q385Q	DUS2L_uc002evj.2_Silent_p.Q385Q|DUS2L_uc010vkk.1_Silent_p.Q350Q|DUS2L_uc010cez.2_Silent_p.Q298Q	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	385	DRBM.				tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)														---	---	---	---
ESRP2	80004	broad.mit.edu	37	16	68266489	68266489	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68266489T>C	uc010cfa.1	-	7	1030	c.842A>G	c.(841-843)AAC>AGC	p.N281S	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.N271S	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	281	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1																		---	---	---	---
PRMT7	54496	broad.mit.edu	37	16	68373316	68373316	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68373316T>C	uc002evy.1	+	8	872	c.596T>C	c.(595-597)ATC>ACC	p.I199T	PRMT7_uc002evx.1_Missense_Mutation_p.I199T|PRMT7_uc010vlg.1_Missense_Mutation_p.I149T|PRMT7_uc002evz.1_Missense_Mutation_p.I45T	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	199					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)														---	---	---	---
PRMT7	54496	broad.mit.edu	37	16	68380154	68380154	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68380154A>G	uc002evy.1	+	11	1438	c.1162A>G	c.(1162-1164)ACT>GCT	p.T388A	PRMT7_uc002evx.1_Missense_Mutation_p.T388A|PRMT7_uc010vlg.1_Missense_Mutation_p.T338A|PRMT7_uc002evz.1_Missense_Mutation_p.T234A	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	388					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)														---	---	---	---
SMPD3	55512	broad.mit.edu	37	16	68405595	68405595	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68405595G>A	uc002ewa.2	-	3	912	c.490C>T	c.(490-492)CGG>TGG	p.R164W	SMPD3_uc010cfe.2_Missense_Mutation_p.R164W|SMPD3_uc010vlh.1_Missense_Mutation_p.R164W	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	164	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)													---	---	---	---
CDH3	1001	broad.mit.edu	37	16	68719188	68719188	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68719188A>G	uc002ewf.2	+	11	2637	c.1505A>G	c.(1504-1506)GAC>GGC	p.D502G	CDH3_uc010vli.1_Missense_Mutation_p.D447G	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	502	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)														---	---	---	---
TMCO7	79613	broad.mit.edu	37	16	68894252	68894252	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68894252C>T	uc002ewi.3	+	2	572	c.560C>T	c.(559-561)GCT>GTT	p.A187V	TMCO7_uc002ewh.2_Missense_Mutation_p.A187V	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	187						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)														---	---	---	---
TMCO7	79613	broad.mit.edu	37	16	69008054	69008054	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69008054G>A	uc002ewi.3	+	15	2837	c.2825G>A	c.(2824-2826)CGA>CAA	p.R942Q		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	942						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)														---	---	---	---
VPS4A	27183	broad.mit.edu	37	16	69354678	69354678	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69354678T>C	uc002eww.2	+							NM_013245	NP_037377			vacuolar protein sorting factor 4A						cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)																---	---	---	---
TMED6	146456	broad.mit.edu	37	16	69385573	69385573	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69385573A>G	uc002exc.1	-	1	117	c.84T>C	c.(82-84)AGT>AGC	p.S28S		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	28	Lumenal (Potential).				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1																		---	---	---	---
NFAT5	10725	broad.mit.edu	37	16	69729043	69729043	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69729043T>C	uc002exm.1	+	13	5573	c.4365T>C	c.(4363-4365)TGT>TGC	p.C1455C	NFAT5_uc002exi.2_Silent_p.C1379C|NFAT5_uc002exj.1_Silent_p.C1379C|NFAT5_uc002exk.1_Silent_p.C1379C|NFAT5_uc002exl.1_Silent_p.C1473C|NFAT5_uc002exn.1_Silent_p.C1472C|NFAT5_uc002exo.1_Intron	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	1455					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
NQO1	1728	broad.mit.edu	37	16	69752360	69752360	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69752360C>T	uc002exp.2	-	2	276	c.85G>A	c.(85-87)GCT>ACT	p.A29T	NQO1_uc010cfm.2_Missense_Mutation_p.A8T|NQO1_uc002exq.2_Missense_Mutation_p.A29T|NQO1_uc002exr.2_Missense_Mutation_p.A29T|NQO1_uc010vll.1_Missense_Mutation_p.A29T	NM_000903	NP_000894	P15559	NQO1_HUMAN	NAD(P)H menadione oxidoreductase 1,	29					nitric oxide biosynthetic process|regulation of cellular amino acid metabolic process|response to toxin|synaptic transmission, cholinergic|xenobiotic metabolic process	cytosol	coenzyme binding|cytochrome-b5 reductase activity|electron carrier activity|NAD(P)H dehydrogenase (quinone) activity				0					Dicumarol(DB00266)|Menadione(DB00170)													---	---	---	---
WWP2	11060	broad.mit.edu	37	16	69971539	69971539	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69971539T>A	uc002exu.1	+	22	2416	c.2327T>A	c.(2326-2328)ATC>AAC	p.I776N	WWP2_uc002exv.1_Missense_Mutation_p.I776N|WWP2_uc010vlm.1_Missense_Mutation_p.I660N|WWP2_uc010vln.1_Missense_Mutation_p.I394N|WWP2_uc002exw.1_Missense_Mutation_p.I337N	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	776	HECT.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6																		---	---	---	---
IL34	146433	broad.mit.edu	37	16	70690978	70690978	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70690978T>C	uc002ezh.1	+	4	739	c.356T>C	c.(355-357)CTG>CCG	p.L119P	IL34_uc002ezi.1_Missense_Mutation_p.L118P	NM_152456	NP_689669	Q6ZMJ4	IL34_HUMAN	interleukin 34 precursor	119					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			central_nervous_system(1)|skin(1)	2																		---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	71127727	71127727	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71127727C>T	uc002ezr.2	-	11	1567	c.1439G>A	c.(1438-1440)TGT>TAT	p.C480Y	HYDIN_uc010cfz.1_Missense_Mutation_p.C225Y|HYDIN_uc002ezv.2_Missense_Mutation_p.C480Y|HYDIN_uc010vmc.1_Missense_Mutation_p.C497Y|HYDIN_uc010vmd.1_Missense_Mutation_p.C507Y|HYDIN_uc002ezw.3_Missense_Mutation_p.C497Y	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	480										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
HYDIN	54768	broad.mit.edu	37	16	71218773	71218773	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71218773G>A	uc002ezr.2	-	3	384	c.256C>T	c.(256-258)CAG>TAG	p.Q86*	HYDIN_uc010cfz.1_5'UTR|HYDIN_uc002ezv.2_Nonsense_Mutation_p.Q86*|HYDIN_uc010vmc.1_Nonsense_Mutation_p.Q103*|HYDIN_uc010vmd.1_Nonsense_Mutation_p.Q113*|HYDIN_uc002ezw.3_Nonsense_Mutation_p.Q103*	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	86										ovary(1)|skin(1)	2		Ovarian(137;0.0654)																---	---	---	---
FTSJD1	55783	broad.mit.edu	37	16	71317627	71317627	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71317627C>T	uc010cga.2	-	3	2603	c.2197G>A	c.(2197-2199)GGG>AGG	p.G733R	FTSJD1_uc002ezy.3_Missense_Mutation_p.G733R|FTSJD1_uc002ezz.3_Missense_Mutation_p.G733R	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	733						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1																		---	---	---	---
TAT	6898	broad.mit.edu	37	16	71609922	71609922	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71609922A>G	uc002fap.2	-	3	342	c.243T>C	c.(241-243)CCT>CCC	p.P81P	TAT_uc002faq.2_Silent_p.P81P|TAT_uc002far.2_Missense_Mutation_p.Y133H	NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	81					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)													---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71799413	71799413	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71799413A>G	uc010cgg.2	-	7	1031	c.717T>C	c.(715-717)GGT>GGC	p.G239G	AP1G1_uc002fba.2_Silent_p.G242G|AP1G1_uc002fbb.2_Silent_p.G262G|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	239					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
DHX38	9785	broad.mit.edu	37	16	72130232	72130232	+	Missense_Mutation	SNP	G	A	A	rs150592983	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72130232G>A	uc002fcb.2	+	2	531	c.176G>A	c.(175-177)CGG>CAG	p.R59Q	TXNL4B_uc010cgl.2_5'Flank|TXNL4B_uc002fca.2_5'Flank|TXNL4B_uc010vmn.1_5'Flank|TXNL4B_uc010vmo.1_5'Flank|DHX38_uc010vmp.1_Missense_Mutation_p.R59Q|DHX38_uc010cgn.1_5'Flank	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	59					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)																---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72828908	72828908	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72828908T>C	uc002fck.2	-	9	8346	c.7673A>G	c.(7672-7674)AAC>AGC	p.N2558S	ZFHX3_uc002fcl.2_Missense_Mutation_p.N1644S	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2558					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72830804	72830804	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72830804C>T	uc002fck.2	-	9	6450	c.5777G>A	c.(5776-5778)GGT>GAT	p.G1926D	ZFHX3_uc002fcl.2_Missense_Mutation_p.G1012D	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1926					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
ZFHX3	463	broad.mit.edu	37	16	72923801	72923801	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72923801A>G	uc002fck.2	-	4	3950	c.3277T>C	c.(3277-3279)TGC>CGC	p.C1093R	ZFHX3_uc002fcl.2_Missense_Mutation_p.C179R	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1093	C2H2-type 9; atypical.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)																---	---	---	---
WDR59	79726	broad.mit.edu	37	16	74920164	74920164	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:74920164T>C	uc002fdh.1	-						WDR59_uc002fdf.1_Intron|WDR59_uc002fdg.1_Intron	NM_030581	NP_085058			WD repeat domain 59											ovary(1)|breast(1)	2																		---	---	---	---
CHST5	23563	broad.mit.edu	37	16	75576591	75576591	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75576591G>A	uc002fej.1	-						TMEM231_uc002fek.2_Intron|TMEM231_uc002fel.2_Intron|TMEM231_uc002fem.2_Intron|TMEM231_uc010vne.1_Intron|TMEM231_uc010cgx.1_Intron	NM_024533	NP_078809			carbohydrate (N-acetylglucosamine 6-O)						N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0																		---	---	---	---
WWOX	51741	broad.mit.edu	37	16	78466543	78466543	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:78466543C>T	uc002ffk.2	+	8	1075	c.950C>T	c.(949-951)ACG>ATG	p.T317M	WWOX_uc010vnk.1_Missense_Mutation_p.T204M|WWOX_uc002ffl.2_Intron|WWOX_uc010che.2_Intron	NM_016373	NP_057457	Q9NZC7	WWOX_HUMAN	WW domain-containing oxidoreductase isoform 1	317	Interaction with MAPT (By similarity).				apoptosis|negative regulation of Wnt receptor signaling pathway|steroid metabolic process|Wnt receptor signaling pathway	Golgi apparatus|mitochondrion|nucleus	coenzyme binding|oxidoreductase activity|protein dimerization activity				0		all_cancers(2;1.97e-181)|all_epithelial(2;3.85e-160)|all_lung(2;2.03e-39)|Lung NSC(2;7.16e-35)|Colorectal(2;6.96e-21)|all_hematologic(2;1.13e-16)|Melanoma(2;5.16e-06)|all_neural(2;8.84e-06)|Renal(2;5.26e-05)|Medulloblastoma(2;0.00498)|Breast(2;0.00631)|Lung SC(2;0.0261)|Prostate(104;0.167)		UCEC - Uterine corpus endometrioid carcinoma (2;0.012)|Epithelial(1;2.65e-39)|all cancers(1;3.26e-34)|STAD - Stomach adenocarcinoma(1;5.1e-20)|COAD - Colon adenocarcinoma(1;1.04e-11)|Colorectal(1;3.4e-11)|OV - Ovarian serous cystadenocarcinoma(1;1.01e-10)|BRCA - Breast invasive adenocarcinoma(1;0.00196)|Kidney(780;0.232)														---	---	---	---
ATMIN	23300	broad.mit.edu	37	16	81077032	81077032	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81077032A>C	uc002ffz.1	+	4	947	c.929A>C	c.(928-930)CAG>CCG	p.Q310P	ATMIN_uc002fga.2_Missense_Mutation_p.Q152P|ATMIN_uc010vnn.1_Missense_Mutation_p.Q81P|ATMIN_uc002fgb.1_Missense_Mutation_p.Q152P	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	310	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0																		---	---	---	---
ATMIN	23300	broad.mit.edu	37	16	81078356	81078356	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81078356A>G	uc002ffz.1	+	4	2271	c.2253A>G	c.(2251-2253)ATA>ATG	p.I751M	ATMIN_uc002fga.2_Missense_Mutation_p.I593M|ATMIN_uc010vnn.1_Missense_Mutation_p.I522M|ATMIN_uc002fgb.1_Missense_Mutation_p.I593M	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	751					response to DNA damage stimulus	nucleus	zinc ion binding				0																		---	---	---	---
PKD1L2	114780	broad.mit.edu	37	16	81161381	81161381	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81161381C>T	uc002fgh.1	-	38	6335	c.6335G>A	c.(6334-6336)CGC>CAC	p.R2112H	PKD1L2_uc002fgf.1_5'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2112	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
GAN	8139	broad.mit.edu	37	16	81411130	81411130	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81411130A>G	uc002fgo.2	+	11	1871	c.1723A>G	c.(1723-1725)ATT>GTT	p.I575V		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	575					cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)																---	---	---	---
CMIP	80790	broad.mit.edu	37	16	81733390	81733390	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81733390A>G	uc002fgp.2	+	15	1811	c.1739A>G	c.(1738-1740)AAC>AGC	p.N580S	CMIP_uc002fgq.1_Missense_Mutation_p.N486S|CMIP_uc010vnq.1_Missense_Mutation_p.N393S|CMIP_uc002fgr.1_Missense_Mutation_p.N427S	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	546						cytoplasm|nucleus					0																		---	---	---	---
PLCG2	5336	broad.mit.edu	37	16	81819728	81819728	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81819728T>C	uc002fgt.2	+	2	286	c.134T>C	c.(133-135)GTG>GCG	p.V45A	PLCG2_uc010chg.1_Missense_Mutation_p.V45A	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	45	PH.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8																		---	---	---	---
CDH13	1012	broad.mit.edu	37	16	83817018	83817018	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:83817018C>T	uc002fgx.2	+	13	2195	c.2075C>T	c.(2074-2076)GCA>GTA	p.A692V	CDH13_uc010vns.1_Missense_Mutation_p.A739V|CDH13_uc010vnt.1_Missense_Mutation_p.A438V|CDH13_uc010vnu.1_Missense_Mutation_p.A653V	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	692	Cadherin 5.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)														---	---	---	---
KIAA1609	57707	broad.mit.edu	37	16	84520276	84520276	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84520276A>G	uc002fib.2	-	5	1026	c.919T>C	c.(919-921)TTT>CTT	p.F307L	KIAA1609_uc010vod.1_Missense_Mutation_p.F280L|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	307	TLD.						protein binding			ovary(2)	2																		---	---	---	---
USP10	9100	broad.mit.edu	37	16	84778843	84778843	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84778843G>T	uc002fii.2	+	4	898	c.756G>T	c.(754-756)CAG>CAT	p.Q252H	USP10_uc010voe.1_Missense_Mutation_p.Q256H|USP10_uc010vof.1_Intron|USP10_uc002fij.2_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	252					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0																		---	---	---	---
KIAA0182	23199	broad.mit.edu	37	16	85689518	85689518	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85689518G>A	uc002fix.2	+	6	1058	c.984G>A	c.(982-984)GCG>GCA	p.A328A	KIAA0182_uc002fiw.2_Silent_p.A224A|KIAA0182_uc002fiy.2_Silent_p.A255A	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	328	Potential.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5																		---	---	---	---
JPH3	57338	broad.mit.edu	37	16	87678007	87678007	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87678007G>A	uc002fkd.2	+	2	780	c.526G>A	c.(526-528)GCG>ACG	p.A176T	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	176	Cytoplasmic (Potential).			A -> P (in Ref. 1; BAB11983).	calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)														---	---	---	---
JPH3	57338	broad.mit.edu	37	16	87678282	87678282	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87678282C>T	uc002fkd.2	+	2	1055	c.801C>T	c.(799-801)GGC>GGT	p.G267G	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	267	Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)														---	---	---	---
ZFPM1	161882	broad.mit.edu	37	16	88599263	88599263	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88599263A>G	uc002fkv.2	+	9	1142	c.1109A>G	c.(1108-1110)AAC>AGC	p.N370S		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	370	C2H2-type 3.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)														---	---	---	---
CYBA	1535	broad.mit.edu	37	16	88714464	88714464	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88714464A>G	uc002flb.2	-	2	153	c.117T>C	c.(115-117)GGT>GGC	p.G39G	CYBA_uc002flc.1_5'Flank|CYBA_uc002fld.1_Silent_p.G39G|CYBA_uc010chx.1_Silent_p.G39G	NM_000101	NP_000092	P13498	CY24A_HUMAN	cytochrome b, alpha polypeptide	39					cytochrome complex assembly|electron transport chain|hydrogen peroxide biosynthetic process|inflammatory response|innate immune response|respiratory burst|smooth muscle hypertrophy|superoxide anion generation|transport	NADPH oxidase complex|stored secretory granule	electron carrier activity|heme binding|protein heterodimerization activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)														---	---	---	---
MVD	4597	broad.mit.edu	37	16	88724403	88724403	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88724403T>C	uc002flg.1	-	3	183	c.176A>G	c.(175-177)GAC>GGC	p.D59G	MVD_uc002flf.1_5'Flank	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	59					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)														---	---	---	---
CBFA2T3	863	broad.mit.edu	37	16	88951603	88951603	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88951603G>A	uc002fmm.1	-	7	1154	c.968C>T	c.(967-969)CCT>CTT	p.P323L	CBFA2T3_uc002fml.1_Missense_Mutation_p.P237L|CBFA2T3_uc010cif.1_Missense_Mutation_p.P262L|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P298L	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	323	Mediates localization to the nucleus (By similarity).|Mediates interaction with PDE7A (in isoform 2).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)				T	RUNX1	AML								---	---	---	---
ANKRD11	29123	broad.mit.edu	37	16	89346505	89346505	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89346505C>T	uc002fmx.1	-	9	6906	c.6445G>A	c.(6445-6447)GCA>ACA	p.A2149T	ANKRD11_uc002fmy.1_Missense_Mutation_p.A2149T|ANKRD11_uc002fnc.1_Missense_Mutation_p.A2149T|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.A2106T	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2149	Pro-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)														---	---	---	---
ANKRD11	29123	broad.mit.edu	37	16	89348369	89348369	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89348369A>G	uc002fmx.1	-	9	5042	c.4581T>C	c.(4579-4581)GAT>GAC	p.D1527D	ANKRD11_uc002fmy.1_Silent_p.D1527D|ANKRD11_uc002fnc.1_Silent_p.D1527D|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Silent_p.D1484D	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1527	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)														---	---	---	---
DPEP1	1800	broad.mit.edu	37	16	89703685	89703685	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89703685C>T	uc010cin.2	+	7	868	c.665C>T	c.(664-666)GCC>GTC	p.A222V	DPEP1_uc002fnr.3_Missense_Mutation_p.A222V|DPEP1_uc002fns.3_Missense_Mutation_p.A222V	NM_001128141	NP_001121613	P16444	DPEP1_HUMAN	dipeptidase 1 precursor	222					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(1)	1		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)													---	---	---	---
SPATA2L	124044	broad.mit.edu	37	16	89764463	89764463	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89764463G>A	uc002foj.2	-	3	619	c.554C>T	c.(553-555)GCA>GTA	p.A185V	SPATA2L_uc002fok.2_Intron	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	185											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)														---	---	---	---
TUBB3	10381	broad.mit.edu	37	16	90002087	90002087	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:90002087G>A	uc002fph.1	+	4	1293	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	TUBB3_uc002fpf.2_Missense_Mutation_p.E757K|TUBB3_uc010ciz.1_Missense_Mutation_p.E338K|TUBB3_uc002fpg.1_Missense_Mutation_p.E264K|TUBB3_uc002fpi.1_Missense_Mutation_p.E338K|TUBB3_uc002fpj.1_Missense_Mutation_p.E338K|TUBB3_uc010cjb.1_Missense_Mutation_p.E264K|TUBB3_uc002fpk.1_Missense_Mutation_p.E264K	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	410			E -> K (in CFEOM3A; severe phenotype with congenital facial weakness; lower extremity weakness and sensory loss in the second to third decade of life in one patient; affects microtubules polymerization and depolymerization rates).		'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)														---	---	---	---
C17orf97	400566	broad.mit.edu	37	17	263612	263612	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:263612C>T	uc002frh.2	+	3	1024	c.1008C>T	c.(1006-1008)CAC>CAT	p.H336H	C17orf97_uc010vpz.1_RNA	NM_001013672	NP_001013694	Q6ZQX7	CQ097_HUMAN	hypothetical protein LOC400566	356	16.|20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									ovary(1)	1																		---	---	---	---
ABR	29	broad.mit.edu	37	17	986819	986819	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:986819C>T	uc002fsd.2	-	5	690	c.580G>A	c.(580-582)GCT>ACT	p.A194T	ABR_uc002fse.2_Missense_Mutation_p.A148T|ABR_uc002fsg.2_Missense_Mutation_p.A157T|ABR_uc002fsh.1_Missense_Mutation_p.A78T	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	194	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)														---	---	---	---
TUSC5	286753	broad.mit.edu	37	17	1183350	1183350	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1183350G>A	uc002fsi.1	+	1	394	c.55G>A	c.(55-57)GCA>ACA	p.A19T		NM_172367	NP_758955	Q8IXB3	TUSC5_HUMAN	LOST1	19					response to biotic stimulus	integral to membrane				skin(2)	2				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
SCARF1	8578	broad.mit.edu	37	17	1538649	1538649	+	Silent	SNP	G	A	A	rs144909941	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1538649G>A	uc002fsz.1	-	11	1946	c.1896C>T	c.(1894-1896)GCC>GCT	p.A632A	SCARF1_uc002fsy.1_3'UTR|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Silent_p.A546A	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	632	Gly-rich.|Cytoplasmic (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
RTN4RL1	146760	broad.mit.edu	37	17	1840972	1840972	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1840972G>A	uc002ftp.2	-	2	163	c.144C>T	c.(142-144)ATC>ATT	p.I48I		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	48	LRRNT.				axon regeneration	anchored to plasma membrane	receptor activity				0																		---	---	---	---
RTN4RL1	146760	broad.mit.edu	37	17	1841027	1841027	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1841027A>G	uc002ftp.2	-	2	108	c.89T>C	c.(88-90)GTG>GCG	p.V30A		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	30	LRRNT.				axon regeneration	anchored to plasma membrane	receptor activity				0																		---	---	---	---
SMG6	23293	broad.mit.edu	37	17	1985095	1985095	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1985095C>T	uc002fub.1	-						SMG6_uc010vqv.1_Intron	NM_017575	NP_060045			Smg-6 homolog, nonsense mediated mRNA decay						mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4																		---	---	---	---
SMG6	23293	broad.mit.edu	37	17	2076067	2076067	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2076067T>C	uc002fub.1	-	13	3297	c.3242A>G	c.(3241-3243)GAC>GGC	p.D1081G	SMG6_uc010vqv.1_Missense_Mutation_p.D173G	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	1081					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4																		---	---	---	---
KIAA0664	23277	broad.mit.edu	37	17	2604947	2604947	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2604947C>T	uc002fuy.1	-	5	676	c.590G>A	c.(589-591)CGG>CAG	p.R197Q	KIAA0664_uc002fux.1_Missense_Mutation_p.R129Q	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	197							binding			breast(2)	2																		---	---	---	---
RAP1GAP2	23108	broad.mit.edu	37	17	2884550	2884550	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2884550C>T	uc010ckd.2	+						RAP1GAP2_uc010cke.2_Intron	NM_015085	NP_055900			RAP1 GTPase activating protein 2 isoform 1						regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1																		---	---	---	---
OR1D2	4991	broad.mit.edu	37	17	2996177	2996177	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2996177C>T	uc010vrb.1	-	1	114	c.114G>A	c.(112-114)ACG>ACA	p.T38T		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	38	Helical; Name=1; (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1																		---	---	---	---
OR1A2	26189	broad.mit.edu	37	17	3101155	3101155	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3101155T>C	uc002fvd.1	+	1	343	c.343T>C	c.(343-345)TTG>CTG	p.L115L		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2																		---	---	---	---
OR1E1	8387	broad.mit.edu	37	17	3301298	3301298	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3301298A>G	uc002fvj.1	-	1	407	c.407T>C	c.(406-408)ATG>ACG	p.M136T		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
TRPV3	162514	broad.mit.edu	37	17	3424299	3424299	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3424299A>G	uc002fvt.1	-	14	2100	c.1778T>C	c.(1777-1779)GTA>GCA	p.V593A	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.V577A|TRPV3_uc010vri.1_Missense_Mutation_p.V548A|TRPV3_uc010vrj.1_Missense_Mutation_p.V577A|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.V577A|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.V593A|TRPV3_uc002fvu.2_Missense_Mutation_p.V593A|TRPV3_uc010vrn.1_3'UTR	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	593	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)													---	---	---	---
ATP2A3	489	broad.mit.edu	37	17	3839611	3839611	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3839611C>T	uc002fxb.1	-	16	2625	c.2474G>A	c.(2473-2475)CGA>CAA	p.R825Q	ATP2A3_uc002fwx.1_Missense_Mutation_p.R825Q|ATP2A3_uc002fwy.1_Missense_Mutation_p.R825Q|ATP2A3_uc002fwz.1_Missense_Mutation_p.R825Q|ATP2A3_uc002fxa.1_Missense_Mutation_p.R825Q|ATP2A3_uc002fxc.1_Missense_Mutation_p.R825Q|ATP2A3_uc002fxd.1_Missense_Mutation_p.R825Q	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	825	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)														---	---	---	---
ATP2A3	489	broad.mit.edu	37	17	3850769	3850769	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3850769C>T	uc002fxb.1	-	8	1162	c.1011G>A	c.(1009-1011)CCG>CCA	p.P337P	ATP2A3_uc002fwx.1_Silent_p.P337P|ATP2A3_uc002fwy.1_Silent_p.P337P|ATP2A3_uc002fwz.1_Silent_p.P337P|ATP2A3_uc002fxa.1_Silent_p.P337P|ATP2A3_uc002fxc.1_Silent_p.P337P|ATP2A3_uc002fxd.1_Silent_p.P337P	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	337	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)														---	---	---	---
ZZEF1	23140	broad.mit.edu	37	17	3981339	3981339	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3981339A>G	uc002fxe.2	-						ZZEF1_uc002fxk.1_Intron	NM_015113	NP_055928			zinc finger, ZZ type with EF hand domain 1								calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
ANKFY1	51479	broad.mit.edu	37	17	4111302	4111302	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4111302A>G	uc002fxq.1	-	6	696	c.658T>C	c.(658-660)TAC>CAC	p.Y220H	ANKFY1_uc002fxn.2_Missense_Mutation_p.Y262H|ANKFY1_uc002fxo.2_Missense_Mutation_p.Y220H|ANKFY1_uc002fxp.2_Missense_Mutation_p.Y220H|ANKFY1_uc010ckp.2_Missense_Mutation_p.Y161H|ANKFY1_uc002fxr.2_Missense_Mutation_p.Y220H	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	220	ANK 1.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3																		---	---	---	---
GGT6	124975	broad.mit.edu	37	17	4462881	4462881	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4462881G>C	uc002fyd.3	-	2	375	c.315C>G	c.(313-315)TAC>TAG	p.Y105*	GGT6_uc010vsb.1_5'UTR|GGT6_uc002fyc.3_Nonsense_Mutation_p.Y105*|GGT6_uc010vsc.1_Nonsense_Mutation_p.Y105*	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	105	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1																		---	---	---	---
TM4SF5	9032	broad.mit.edu	37	17	4685894	4685894	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4685894T>G	uc002fyw.1	+	3	386	c.355T>G	c.(355-357)TTA>GTA	p.L119V		NM_003963	NP_003954	O14894	T4S5_HUMAN	transmembrane 4 superfamily member 5	119	Extracellular (Potential).					integral to plasma membrane				ovary(1)	1																		---	---	---	---
MINK1	50488	broad.mit.edu	37	17	4796762	4796762	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4796762G>A	uc010vsl.1	+	21	2630	c.2434G>A	c.(2434-2436)GAG>AAG	p.E812K	MINK1_uc010vsk.1_Missense_Mutation_p.E783K|MINK1_uc010vsm.1_Missense_Mutation_p.E792K|MINK1_uc010vsn.1_Missense_Mutation_p.E775K|MINK1_uc010vso.1_Missense_Mutation_p.E720K|MINK1_uc010vsp.1_Missense_Mutation_p.E273K	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	812					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6																		---	---	---	---
KIF1C	10749	broad.mit.edu	37	17	4905794	4905794	+	Silent	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4905794A>C	uc002gan.1	+	7	791	c.465A>C	c.(463-465)CGA>CGC	p.R155R		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	155	Kinesin-motor.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2																		---	---	---	---
KIF1C	10749	broad.mit.edu	37	17	4927012	4927012	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4927012G>A	uc002gan.1	+	23	3204	c.2878G>A	c.(2878-2880)GGG>AGG	p.G960R		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	960				SGGRGGGL -> LWGPGRGV (in Ref. 1; AAC52117).	microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2																		---	---	---	---
KIF1C	10749	broad.mit.edu	37	17	4927266	4927266	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4927266T>C	uc002gan.1	+	23	3458	c.3132T>C	c.(3130-3132)GGT>GGC	p.G1044G		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	1044	Pro-rich.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2																		---	---	---	---
C17orf87	388325	broad.mit.edu	37	17	5114221	5114221	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5114221C>T	uc002gbh.2	-	5	346	c.313G>A	c.(313-315)GCT>ACT	p.A105T	uc002gbf.1_Intron|uc002gbg.1_Intron|C17orf87_uc010clb.1_Missense_Mutation_p.A98T	NM_207103	NP_996986	Q6UWF3	CQ087_HUMAN	hypothetical protein LOC388325	105						integral to membrane				ovary(1)	1																		---	---	---	---
RABEP1	9135	broad.mit.edu	37	17	5253788	5253788	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5253788T>C	uc002gbm.3	+	7	1051	c.827T>C	c.(826-828)TTA>TCA	p.L276S	RABEP1_uc010clc.1_Missense_Mutation_p.L269S|RABEP1_uc010cld.1_Missense_Mutation_p.L233S|RABEP1_uc010vsw.1_Missense_Mutation_p.L233S|RABEP1_uc002gbl.3_Missense_Mutation_p.L276S	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	276	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
RABEP1	9135	broad.mit.edu	37	17	5264841	5264841	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5264841G>A	uc002gbm.3	+	9	1658	c.1434G>A	c.(1432-1434)GCG>GCA	p.A478A	RABEP1_uc010clc.1_Silent_p.A471A|RABEP1_uc010cld.1_Silent_p.A435A|RABEP1_uc010vsw.1_Silent_p.A435A|RABEP1_uc002gbl.3_Silent_p.A478A|NUP88_uc002gbn.2_RNA	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	478					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2																		---	---	---	---
KIAA0753	9851	broad.mit.edu	37	17	6498335	6498335	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6498335G>A	uc002gde.3	-	16	2756	c.2397C>T	c.(2395-2397)ATC>ATT	p.I799I	KIAA0753_uc010vtd.1_Silent_p.I255I|KIAA0753_uc010clo.2_Silent_p.I500I|KIAA0753_uc010vte.1_Silent_p.I500I	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	799						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)														---	---	---	---
SLC13A5	284111	broad.mit.edu	37	17	6606404	6606404	+	Missense_Mutation	SNP	G	A	A	rs142320179		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6606404G>A	uc002gdj.2	-	5	689	c.601C>T	c.(601-603)CGG>TGG	p.R201W	SLC13A5_uc010vtf.1_Missense_Mutation_p.R201W|SLC13A5_uc010clq.2_Missense_Mutation_p.R158W|SLC13A5_uc002gdk.2_Missense_Mutation_p.R184W|SLC13A5_uc002gdl.1_Missense_Mutation_p.R183W	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	201						integral to membrane	citrate transmembrane transporter activity				0																		---	---	---	---
XAF1	54739	broad.mit.edu	37	17	6661451	6661451	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6661451T>C	uc002gdn.2	+	2	318	c.76T>C	c.(76-78)TAC>CAC	p.Y26H	XAF1_uc010clr.1_Missense_Mutation_p.Y26H|XAF1_uc002gdm.1_5'UTR|XAF1_uc002gdo.2_Missense_Mutation_p.Y26H|XAF1_uc002gdp.2_Silent_p.L3L|XAF1_uc002gdq.2_5'UTR|XAF1_uc002gdr.2_Silent_p.L3L	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	26	TRAF-type.				apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0																		---	---	---	---
DLG4	1742	broad.mit.edu	37	17	7096856	7096856	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7096856C>T	uc002get.3	-	18	2969	c.1768G>A	c.(1768-1770)GCC>ACC	p.A590T	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.A487T|DLG4_uc010cly.2_Missense_Mutation_p.A544T|DLG4_uc010vto.1_Missense_Mutation_p.A587T	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	547	Guanylate kinase-like.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2																		---	---	---	---
DLG4	1742	broad.mit.edu	37	17	7111483	7111483	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7111483G>T	uc002get.3	-						DLG4_uc010cly.2_Intron|DLG4_uc010vto.1_Intron|DLG4_uc002geu.2_Intron	NM_001365	NP_001356			post-synaptic density protein 95 isoform 1						axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2																		---	---	---	---
EIF5A	1984	broad.mit.edu	37	17	7214949	7214949	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7214949T>C	uc010vtv.1	+	5	692	c.455T>C	c.(454-456)ATG>ACG	p.M152T	EIF5A_uc002gfr.2_Missense_Mutation_p.M182T|EIF5A_uc002gft.2_Missense_Mutation_p.M152T|EIF5A_uc002gfu.2_Missense_Mutation_p.M152T	NM_001970	NP_001961	P63241	IF5A1_HUMAN	eukaryotic translation initiation factor 5A	152					induction of apoptosis|mRNA export from nucleus|peptidyl-lysine modification to hypusine|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein export from nucleus|translational frameshifting|transmembrane transport	annulate lamellae|cytosol|endoplasmic reticulum membrane|nuclear pore	protein N-terminus binding|ribosome binding|translation elongation factor activity|U6 snRNA binding				0																		---	---	---	---
TMEM95	339168	broad.mit.edu	37	17	7259720	7259720	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7259720A>G	uc002ggh.1	+	6	446	c.419A>G	c.(418-420)GAT>GGT	p.D140G	TMEM95_uc002ggf.1_Missense_Mutation_p.D148G|TMEM95_uc002ggg.1_Silent_p.G137G	NM_198154	NP_937797	Q3KNT9	TMM95_HUMAN	transmembrane protein 95	140	Extracellular (Potential).					integral to membrane					0		Prostate(122;0.173)														OREG0024137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PLSCR3	57048	broad.mit.edu	37	17	7296194	7296194	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7296194G>A	uc002ggm.1	-	6	794	c.585C>T	c.(583-585)TCC>TCT	p.S195S	PLSCR3_uc002ggl.2_Silent_p.S171S|PLSCR3_uc002ggq.1_Silent_p.S26S|PLSCR3_uc002ggn.1_Silent_p.S195S|PLSCR3_uc002ggo.1_Silent_p.S195S|PLSCR3_uc002ggp.1_Silent_p.S26S|PLSCR3_uc002ggr.1_Silent_p.S195S|PLSCR3_uc010cmg.1_Silent_p.S195S	NM_020360	NP_065093	Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	195	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding				0		Prostate(122;0.173)																---	---	---	---
POLR2A	5430	broad.mit.edu	37	17	7406583	7406583	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7406583G>T	uc002ghf.3	+	17	3134	c.2900G>T	c.(2899-2901)AGG>ATG	p.R967M		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	967					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)																---	---	---	---
POLR2A	5430	broad.mit.edu	37	17	7417203	7417203	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7417203T>C	uc002ghf.3	+	29	5854	c.5620T>C	c.(5620-5622)TAC>CAC	p.Y1874H		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1874	41.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)																---	---	---	---
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	A	A	rs121913343		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
TP53	7157	broad.mit.edu	37	17	7578407	7578407	+	Missense_Mutation	SNP	G	A	A	rs138729528		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7578407G>A	uc002gim.2	-	5	717	c.523C>T	c.(523-525)CGC>TGC	p.R175C	TP53_uc002gig.1_Missense_Mutation_p.R175C|TP53_uc002gih.2_Missense_Mutation_p.R175C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43C|TP53_uc010cng.1_Missense_Mutation_p.R43C|TP53_uc002gii.1_Missense_Mutation_p.R43C|TP53_uc010cnh.1_Missense_Mutation_p.R175C|TP53_uc010cni.1_Missense_Mutation_p.R175C|TP53_uc002gij.2_Missense_Mutation_p.R175C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82C|TP53_uc002gio.2_Missense_Mutation_p.R43C|TP53_uc010vug.1_Missense_Mutation_p.R136C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(721)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.S149fs*72(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)			111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
TP53	7157	broad.mit.edu	37	17	7578419	7578419	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7578419C>T	uc002gim.2	-	5	705	c.511G>A	c.(511-513)GAG>AAG	p.E171K	TP53_uc002gig.1_Missense_Mutation_p.E171K|TP53_uc002gih.2_Missense_Mutation_p.E171K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E39K|TP53_uc010cng.1_Missense_Mutation_p.E39K|TP53_uc002gii.1_Missense_Mutation_p.E39K|TP53_uc010cnh.1_Missense_Mutation_p.E171K|TP53_uc010cni.1_Missense_Mutation_p.E171K|TP53_uc002gij.2_Missense_Mutation_p.E171K|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.E78K|TP53_uc002gio.2_Missense_Mutation_p.E39K|TP53_uc010vug.1_Missense_Mutation_p.E132K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)			111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7630616	7630616	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7630616T>C	uc002giu.1	+						DNAH2_uc002git.2_Intron|DNAH2_uc010vuk.1_Intron	NM_020877	NP_065928			dynein heavy chain domain 3						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7636499	7636499	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7636499G>A	uc002giu.1	+	4	508	c.494G>A	c.(493-495)GGC>GAC	p.G165D	DNAH2_uc002git.2_Missense_Mutation_p.G165D|DNAH2_uc010vuk.1_Missense_Mutation_p.G165D	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	165	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7644171	7644171	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7644171T>C	uc002giu.1	+	10	1564	c.1550T>C	c.(1549-1551)ATG>ACG	p.M517T	DNAH2_uc002git.2_Missense_Mutation_p.M599T|DNAH2_uc010vuk.1_Missense_Mutation_p.M517T	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	517	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7646246	7646246	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7646246T>C	uc002giu.1	+	11	1704	c.1690T>C	c.(1690-1692)TGC>CGC	p.C564R	DNAH2_uc002git.2_Missense_Mutation_p.C646R|DNAH2_uc010vuk.1_Missense_Mutation_p.C564R	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	564	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
DNAH2	146754	broad.mit.edu	37	17	7721664	7721664	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7721664G>A	uc002giu.1	+	68	10436	c.10422G>A	c.(10420-10422)GAG>GAA	p.E3474E	DNAH2_uc010cnm.1_Silent_p.E412E	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3474	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)																---	---	---	---
KDM6B	23135	broad.mit.edu	37	17	7748989	7748989	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7748989C>T	uc002giw.1	+	4	493	c.117C>T	c.(115-117)AGC>AGT	p.S39S	KDM6B_uc002gix.2_5'Flank	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	39	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
KDM6B	23135	broad.mit.edu	37	17	7752900	7752900	+	Silent	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7752900G>C	uc002giw.1	+	11	3670	c.3294G>C	c.(3292-3294)GGG>GGC	p.G1098G	KDM6B_uc002gix.2_Silent_p.G400G	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1098					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
TRAPPC1	58485	broad.mit.edu	37	17	7834014	7834014	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7834014C>T	uc002gjo.1	-	4	464	c.348G>A	c.(346-348)CCG>CCA	p.P116P	KCNAB3_uc002gjm.1_5'Flank|KCNAB3_uc010vul.1_5'Flank|CNTROB_uc002gjp.2_5'Flank|CNTROB_uc002gjq.2_5'Flank	NM_021210	NP_067033	Q9Y5R8	TPPC1_HUMAN	trafficking protein particle complex 1	116					ER to Golgi vesicle-mediated transport	endoplasmic reticulum					0		Prostate(122;0.173)																---	---	---	---
C17orf68	80169	broad.mit.edu	37	17	8136238	8136238	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8136238T>C	uc002gkq.3	-	11	1990	c.1931A>G	c.(1930-1932)GAC>GGC	p.D644G	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	644					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0																		---	---	---	---
ARHGEF15	22899	broad.mit.edu	37	17	8222131	8222131	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8222131T>C	uc002glc.2	+	12	2057	c.1936T>C	c.(1936-1938)TGC>CGC	p.C646R	ARHGEF15_uc002gld.2_Missense_Mutation_p.C646R|ARHGEF15_uc010vuw.1_Missense_Mutation_p.C535R	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	646					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3																		---	---	---	---
MYH10	4628	broad.mit.edu	37	17	8384695	8384695	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8384695C>T	uc002gll.2	-	36	5212	c.5116G>A	c.(5116-5118)GCC>ACC	p.A1706T	MYH10_uc002glm.2_Missense_Mutation_p.A1737T|MYH10_uc010cnx.2_Missense_Mutation_p.A1715T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1706	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2																		---	---	---	---
PIK3R6	146850	broad.mit.edu	37	17	8738627	8738627	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8738627T>C	uc002glq.1	-	8	848	c.608A>G	c.(607-609)GAG>GGG	p.E203G	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	203					platelet activation	cytosol					0																		---	---	---	---
PIK3R5	23533	broad.mit.edu	37	17	8784052	8784052	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8784052T>C	uc002glt.2	-	19	2614	c.2547A>G	c.(2545-2547)CCA>CCG	p.P849P	PIK3R5_uc010vuz.1_Silent_p.P849P|PIK3R5_uc002glu.3_Silent_p.P463P	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	849					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
PIK3R5	23533	broad.mit.edu	37	17	8794162	8794162	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8794162T>C	uc002glt.2	-	7	617	c.550A>G	c.(550-552)ACG>GCG	p.T184A	PIK3R5_uc010vuz.1_Missense_Mutation_p.T184A|PIK3R5_uc002glu.3_Intron|PIK3R5_uc010coa.1_Missense_Mutation_p.T184A|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	184					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
RCVRN	5957	broad.mit.edu	37	17	9808152	9808152	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9808152T>C	uc002gme.1	-	1	533	c.346A>G	c.(346-348)ACC>GCC	p.T116A		NM_002903	NP_002894	P35243	RECO_HUMAN	recoverin	116	EF-hand 3.|2; high affinity (By similarity).				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0																		---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10247249	10247249	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10247249C>T	uc002gmk.1	-	16	1852	c.1762G>A	c.(1762-1764)GTG>ATG	p.V588M	MYH13_uc010vvf.1_Missense_Mutation_p.V263M	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	588	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
MYH13	8735	broad.mit.edu	37	17	10263318	10263318	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10263318T>C	uc002gmk.1	-	7	694	c.604A>G	c.(604-606)ACC>GCC	p.T202A		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	202	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6																		---	---	---	---
MYH4	4622	broad.mit.edu	37	17	10356187	10356187	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10356187T>C	uc002gmn.2	-	25	3285	c.3174A>G	c.(3172-3174)AAA>AAG	p.K1058K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1058	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13																		---	---	---	---
MYH3	4621	broad.mit.edu	37	17	10545866	10545866	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10545866T>C	uc002gmq.1	-	15	1833	c.1756A>G	c.(1756-1758)ACC>GCC	p.T586A		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	586	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7																		---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11543707	11543707	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11543707T>C	uc002gne.2	+							NM_001372	NP_001363			dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11631246	11631246	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11631246G>A	uc002gne.2	+						DNAH9_uc010coo.2_Intron	NM_001372	NP_001363			dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11672478	11672478	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11672478T>C	uc002gne.2	+	38	7452	c.7384T>C	c.(7384-7386)TAC>CAC	p.Y2462H	DNAH9_uc010coo.2_Missense_Mutation_p.Y1756H	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2462	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
MYOCD	93649	broad.mit.edu	37	17	12639545	12639545	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12639545G>A	uc002gnn.2	+	6	782	c.483G>A	c.(481-483)GGG>GGA	p.G161G	MYOCD_uc002gno.2_Silent_p.G161G|MYOCD_uc002gnp.1_Silent_p.G65G	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	161	HDAC5-binding (By similarity).				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)														---	---	---	---
MYOCD	93649	broad.mit.edu	37	17	12649294	12649294	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12649294A>G	uc002gnn.2	+	9	1329	c.1030A>G	c.(1030-1032)ACC>GCC	p.T344A	MYOCD_uc002gno.2_Missense_Mutation_p.T344A|MYOCD_uc002gnp.1_Missense_Mutation_p.T248A|MYOCD_uc002gnq.2_Missense_Mutation_p.T63A	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	344					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)														---	---	---	---
ADORA2B	136	broad.mit.edu	37	17	15848647	15848647	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15848647T>C	uc002gpd.1	+	1	417	c.85T>C	c.(85-87)TGC>CGC	p.C29R		NM_000676	NP_000667	P29275	AA2BR_HUMAN	adenosine A2b receptor	29	Helical; Name=1; (By similarity).				activation of MAPK activity|cellular defense response|excretion|JNK cascade	integral to plasma membrane				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0855)	Defibrotide(DB04932)|Enprofylline(DB00824)|Pegademase bovine(DB00061)|Theophylline(DB00277)													---	---	---	---
NCOR1	9611	broad.mit.edu	37	17	15989674	15989674	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15989674C>T	uc002gpo.2	-	23	3339	c.3099G>A	c.(3097-3099)CCG>CCA	p.P1033P	NCOR1_uc002gpn.2_Silent_p.P1049P|NCOR1_uc002gpp.1_Silent_p.P940P|NCOR1_uc002gpq.1_Silent_p.P125P	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1033	Interaction with ETO.|Poly-Pro.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)														---	---	---	---
TRPV2	51393	broad.mit.edu	37	17	16335135	16335135	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16335135A>G	uc002gpy.2	+	11	1992	c.1625A>G	c.(1624-1626)TAC>TGC	p.Y542C	TRPV2_uc002gpz.2_Missense_Mutation_p.Y112C	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	542	Helical; (Potential).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)														---	---	---	---
C17orf76	388341	broad.mit.edu	37	17	16347255	16347255	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16347255T>C	uc010cph.1	-	4	858	c.682A>G	c.(682-684)ACC>GCC	p.T228A	C17orf76_uc002gqh.2_Missense_Mutation_p.H189R|NCRNA00188_uc010vwl.1_Intron|NCRNA00188_uc010vwm.1_Intron|NCRNA00188_uc010vwn.1_Intron|NCRNA00188_uc010cpe.2_Intron|NCRNA00188_uc010vwo.1_Intron|NCRNA00188_uc010vwp.1_Intron|C17orf76_uc002gqg.1_3'UTR	NM_001113567	NP_001107039	Q8NAA5	CQ076_HUMAN	hypothetical protein LOC388341 isoform 1	228											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0887)														---	---	---	---
ZNF624	57547	broad.mit.edu	37	17	16527608	16527608	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:16527608T>C	uc010cpi.1	-	6	675	c.592A>G	c.(592-594)ACT>GCT	p.T198A		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)														---	---	---	---
COPS3	8533	broad.mit.edu	37	17	17168289	17168289	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17168289A>G	uc002grd.2	-	6	539	c.448T>C	c.(448-450)TTG>CTG	p.L150L	COPS3_uc010vwv.1_Silent_p.L130L|COPS3_uc010vww.1_Silent_p.L20L	NM_003653	NP_003644	Q9UNS2	CSN3_HUMAN	COP9 constitutive photomorphogenic homolog	150					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			skin(1)	1																		---	---	---	---
RAI1	10743	broad.mit.edu	37	17	17712704	17712704	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17712704G>A	uc002grm.2	+	5	6129	c.5660G>A	c.(5659-5661)GGT>GAT	p.G1887D		NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1887	PHD-type.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)														---	---	---	---
TOM1L2	146691	broad.mit.edu	37	17	17764788	17764788	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17764788A>G	uc002grz.3	-	12	1435	c.1278_splice	c.e12+1	p.G426_splice	TOM1L2_uc002gry.3_Splice_Site_p.G376_splice|TOM1L2_uc010vwy.1_Splice_Site_p.G373_splice|TOM1L2_uc010cpr.2_Splice_Site_p.G381_splice|TOM1L2_uc010vwz.1_Splice_Site_p.G278_splice|TOM1L2_uc010vxa.1_Splice_Site_p.G328_splice|TOM1L2_uc002grv.3_Splice_Site_p.G159_splice	NM_001082968	NP_001076437			target of myb1-like 2 isoform 3						intracellular protein transport	intracellular					0	all_neural(463;0.228)																	---	---	---	---
LRRC48	83450	broad.mit.edu	37	17	17891390	17891390	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17891390A>G	uc010vxd.1	+	6	801	c.422A>G	c.(421-423)AAC>AGC	p.N141S	LRRC48_uc002gsa.2_Missense_Mutation_p.N141S|LRRC48_uc010vxc.1_Missense_Mutation_p.N141S|LRRC48_uc002gsb.2_Missense_Mutation_p.N141S	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	141	LRR 5.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)																	---	---	---	---
LRRC48	83450	broad.mit.edu	37	17	17898317	17898317	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17898317C>T	uc010vxd.1	+	9	1095	c.716C>T	c.(715-717)GCG>GTG	p.A239V	LRRC48_uc002gsa.2_Missense_Mutation_p.A239V|LRRC48_uc010vxc.1_Missense_Mutation_p.A239V|LRRC48_uc002gsb.2_Missense_Mutation_p.A239V|LRRC48_uc010vxe.1_5'Flank	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	239	Potential.					cytoplasm				pancreas(1)	1	all_neural(463;0.228)																	---	---	---	---
DRG2	1819	broad.mit.edu	37	17	18005257	18005257	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18005257T>C	uc002gsh.1	+	9	807	c.752T>C	c.(751-753)ATC>ACC	p.I251T	DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.I251T	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	251					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)																	---	---	---	---
DRG2	1819	broad.mit.edu	37	17	18010553	18010553	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18010553A>G	uc002gsh.1	+	13	1149	c.1094A>G	c.(1093-1095)TAA>TGA	p.*365*	DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_3'UTR|MYO15A_uc010vxh.1_5'Flank	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	365					signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)																	---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18043900	18043900	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18043900G>A	uc010vxh.1	+	19	5619	c.5281G>A	c.(5281-5283)GTC>ATC	p.V1761I		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1761	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)															OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FLII	2314	broad.mit.edu	37	17	18148506	18148506	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18148506G>A	uc002gsr.1	-	30	3807	c.3756C>T	c.(3754-3756)CAC>CAT	p.H1252H	FLII_uc002gsq.1_Silent_p.H1123H|FLII_uc010cpy.1_Silent_p.H1241H|FLII_uc010vxn.1_Silent_p.H1221H|FLII_uc010vxo.1_Silent_p.H1197H	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	1252					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)																	---	---	---	---
TOP3A	7156	broad.mit.edu	37	17	18181368	18181368	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18181368G>A	uc002gsx.1	-	18	2677	c.2448C>T	c.(2446-2448)GGC>GGT	p.G816G	TOP3A_uc010cpz.1_Silent_p.G268G|TOP3A_uc010vxr.1_Silent_p.G346G|TOP3A_uc002gsw.1_Silent_p.G268G|TOP3A_uc010vxs.1_Silent_p.G714G	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	816	1.|2 X 27 AA approximate repeats.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3																		---	---	---	---
TBC1D28	254272	broad.mit.edu	37	17	18542507	18542507	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18542507A>G	uc002gud.2	-	6	591	c.179T>C	c.(178-180)GTC>GCC	p.V60A		NM_001039397	NP_001034486	Q2M2D7	TBC28_HUMAN	TBC1 domain family, member 28	60						intracellular	Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
FBXW10	10517	broad.mit.edu	37	17	18673283	18673283	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18673283G>A	uc002guk.2	+	11	2123	c.1891G>A	c.(1891-1893)GCC>ACC	p.A631T	FBXW10_uc002guj.2_Missense_Mutation_p.A631T|FBXW10_uc002gul.2_Missense_Mutation_p.A660T|FBXW10_uc010cqh.1_Intron	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	631	WD 7.									ovary(1)	1																		---	---	---	---
FAM83G	644815	broad.mit.edu	37	17	18907282	18907282	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18907282A>G	uc002guw.2	-	2	240	c.73T>C	c.(73-75)TTC>CTC	p.F25L	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	25										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MAPK7	5598	broad.mit.edu	37	17	19284578	19284578	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19284578T>C	uc002gvn.2	+	4	1442	c.1056T>C	c.(1054-1056)GAT>GAC	p.D352D	MAPK7_uc002gvo.2_Silent_p.D213D|MAPK7_uc002gvq.2_Silent_p.D352D|MAPK7_uc002gvp.2_Silent_p.D352D	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	352	Necessary for oligomerization (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)																	---	---	---	---
C17orf103	256302	broad.mit.edu	37	17	21147535	21147535	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21147535A>C	uc010vzx.1	-	3	111	c.109T>G	c.(109-111)TGT>GGT	p.C37G		NM_152914	NP_690878	Q8N6N6	GTL3B_HUMAN	transcript expressed during hematopoiesis 2	37											0																		---	---	---	---
TNFAIP1	7126	broad.mit.edu	37	17	26671585	26671585	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26671585G>A	uc002hax.1	+	7	929	c.910G>A	c.(910-912)GAT>AAT	p.D304N	TNFAIP1_uc002hay.2_Missense_Mutation_p.D304N|TNFAIP1_uc010waf.1_Missense_Mutation_p.D200N	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	304					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)														---	---	---	---
VTN	7448	broad.mit.edu	37	17	26695960	26695960	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26695960G>A	uc002hbc.2	-	5	908	c.759C>T	c.(757-759)AAC>AAT	p.N253N	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	253					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)													---	---	---	---
VTN	7448	broad.mit.edu	37	17	26697198	26697198	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26697198T>C	uc002hbc.2	-	1	176	c.27A>G	c.(25-27)ATA>ATG	p.I9M	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	9					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)													---	---	---	---
ALDOC	230	broad.mit.edu	37	17	26900951	26900951	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26900951T>C	uc002hbp.2	-	8	946	c.801A>G	c.(799-801)GGA>GGG	p.G267G	PIGS_uc002hbn.2_5'Flank|PIGS_uc002hbo.2_5'Flank|PIGS_uc010wap.1_5'Flank|ALDOC_uc010cro.2_Silent_p.G239G	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	267					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)																	---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26962262	26962262	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26962262A>G	uc002hbu.2	-	16	2442	c.2343T>C	c.(2341-2343)AGT>AGC	p.S781S		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	781						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
SUPT6H	6830	broad.mit.edu	37	17	27011678	27011678	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27011678C>T	uc002hby.2	+	18	2394	c.2304C>T	c.(2302-2304)GAC>GAT	p.D768D	SUPT6H_uc010crt.2_Silent_p.D768D	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	768					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)																	---	---	---	---
SUPT6H	6830	broad.mit.edu	37	17	27014226	27014226	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27014226A>G	uc002hby.2	+	22	2911	c.2821A>G	c.(2821-2823)AAG>GAG	p.K941E	SUPT6H_uc010crt.2_Missense_Mutation_p.K941E|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	941					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)																	---	---	---	---
SUPT6H	6830	broad.mit.edu	37	17	27016471	27016471	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27016471A>G	uc002hby.2	+	25	3324	c.3234A>G	c.(3232-3234)GAA>GAG	p.E1078E	SUPT6H_uc010crt.2_Silent_p.E1078E|SUPT6H_uc002hbz.1_Silent_p.E10E	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1078					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)																	---	---	---	---
FLOT2	2319	broad.mit.edu	37	17	27208887	27208887	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27208887G>A	uc002hdc.2	-	8	982	c.859C>T	c.(859-861)CGC>TGC	p.R287C		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	287					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)															---	---	---	---
TIAF1	9220	broad.mit.edu	37	17	27400961	27400961	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27400961T>C	uc002hdv.1	-	1	1667	c.257A>G	c.(256-258)CAG>CGG	p.Q86R	MYO18A_uc010wbc.1_3'UTR|MYO18A_uc002hds.2_3'UTR|MYO18A_uc010csa.1_3'UTR|MYO18A_uc002hdt.1_3'UTR|MYO18A_uc002hdu.1_3'UTR	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1	86					anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)															---	---	---	---
MYO18A	399687	broad.mit.edu	37	17	27425890	27425890	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27425890G>A	uc002hdt.1	-	23	3892	c.3734C>T	c.(3733-3735)CCC>CTC	p.P1245L	MYO18A_uc010wbc.1_Missense_Mutation_p.P787L|MYO18A_uc002hds.2_Missense_Mutation_p.P787L|MYO18A_uc010csa.1_Missense_Mutation_p.P1245L|MYO18A_uc002hdu.1_Missense_Mutation_p.P1245L|MYO18A_uc010wbd.1_Missense_Mutation_p.P914L	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1245					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)															---	---	---	---
TAOK1	57551	broad.mit.edu	37	17	27802738	27802738	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27802738T>C	uc002hdz.1	+	4	449	c.255T>C	c.(253-255)CAT>CAC	p.H85H	TAOK1_uc010wbe.1_Silent_p.H85H|TAOK1_uc010wbf.1_Silent_p.H85H	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	85	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)															---	---	---	---
EFCAB5	374786	broad.mit.edu	37	17	28417508	28417508	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28417508A>G	uc002het.2	+	20	3945	c.3753A>G	c.(3751-3753)ATA>ATG	p.I1251M	EFCAB5_uc010cse.2_Missense_Mutation_p.I1006M|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1251							calcium ion binding			ovary(1)|skin(1)	2																		---	---	---	---
SLC6A4	6532	broad.mit.edu	37	17	28542674	28542674	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28542674A>G	uc002hey.3	-	8	1575	c.1031T>C	c.(1030-1032)CTG>CCG	p.L344P		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	344	Helical; Name=6; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)													---	---	---	---
SLC6A4	6532	broad.mit.edu	37	17	28545342	28545342	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28545342G>T	uc002hey.3	-	5	1036	c.492C>A	c.(490-492)GCC>GCA	p.A164A		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	164	Helical; Name=3; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)													---	---	---	---
GOSR1	9527	broad.mit.edu	37	17	28804459	28804459	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28804459C>T	uc002hfe.2	+	1	34	c.8C>T	c.(7-9)GCA>GTA	p.A3V	GOSR1_uc002hfd.2_Missense_Mutation_p.A3V|GOSR1_uc002hff.2_5'UTR|GOSR1_uc002hfc.1_Missense_Mutation_p.A3V	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	3	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0																OREG0024301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
C17orf42	79736	broad.mit.edu	37	17	29231314	29231314	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29231314G>A	uc002hfu.2	-	2	335	c.265C>T	c.(265-267)CGA>TGA	p.R89*	C17orf42_uc002hfv.2_RNA|C17orf42_uc002hfw.2_Nonsense_Mutation_p.R89*|C17orf42_uc010wbs.1_Nonsense_Mutation_p.R89*	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	89					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)																---	---	---	---
NF1	4763	broad.mit.edu	37	17	29550514	29550514	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29550514A>G	uc002hgg.2	+	16	2107	c.1774A>G	c.(1774-1776)AGT>GGT	p.S592G	NF1_uc002hgh.2_Missense_Mutation_p.S592G|NF1_uc010csn.1_Missense_Mutation_p.S452G|NF1_uc002hgi.1_5'Flank	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	592					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
NF1	4763	broad.mit.edu	37	17	29559874	29559874	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29559874A>G	uc002hgg.2	+	26	3804	c.3471A>G	c.(3469-3471)GTA>GTG	p.V1157V	NF1_uc002hgh.2_Silent_p.V1157V|NF1_uc010csn.1_Silent_p.V1017V|NF1_uc002hgi.1_Silent_p.V190V	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1157					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
NF1	4763	broad.mit.edu	37	17	29701123	29701123	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29701123C>T	uc002hgg.2	+	58	8803	c.8470C>T	c.(8470-8472)CAA>TAA	p.Q2824*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q2803*|NF1_uc010cso.2_Nonsense_Mutation_p.Q1030*|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2824					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
UTP6	55813	broad.mit.edu	37	17	30190399	30190399	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30190399C>T	uc002hgr.2	-	19	1856	c.1773G>A	c.(1771-1773)ATG>ATA	p.M591I	UTP6_uc002hgq.2_Missense_Mutation_p.M407I|UTP6_uc010cst.2_Missense_Mutation_p.M440I	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	591					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)																---	---	---	---
RHOT1	55288	broad.mit.edu	37	17	30536447	30536447	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30536447C>A	uc002hgz.2	+						RHOT1_uc002hgw.2_Silent_p.V606V|RHOT1_uc002hgy.2_Intron|RHOT1_uc002hha.2_Silent_p.V479V|RHOT1_uc010csv.2_Intron|RHOT1_uc002hgx.2_Intron|RHOT1_uc010wby.1_Silent_p.V606V|RHOT1_uc002hhb.2_Intron|RHOT1_uc002hgv.2_3'UTR	NM_018307	NP_060777			ras homolog gene family, member T1 isoform 3						apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)																---	---	---	---
MYO1D	4642	broad.mit.edu	37	17	30986329	30986329	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30986329G>A	uc002hho.1	-	17	2161	c.2149C>T	c.(2149-2151)CGG>TGG	p.R717W	MYO1D_uc002hhp.1_Missense_Mutation_p.R717W	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	717	IQ 1.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)													OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TMEM98	26022	broad.mit.edu	37	17	31260324	31260324	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:31260324G>A	uc002hhq.2	+	4	721	c.263_splice	c.e4+1	p.S88_splice	TMEM98_uc002hhr.2_Splice_Site_p.S88_splice	NM_015544	NP_056359			transmembrane protein 98							endoplasmic reticulum|integral to membrane					0		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)															---	---	---	---
ACCN1	40	broad.mit.edu	37	17	31438937	31438937	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:31438937G>A	uc002hhu.2	-	2	978	c.704C>T	c.(703-705)ACA>ATA	p.T235I	ACCN1_uc002hht.2_Missense_Mutation_p.T286I	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	235	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)													---	---	---	---
FNDC8	54752	broad.mit.edu	37	17	33448908	33448908	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33448908A>G	uc002hix.2	+	1	278	c.196A>G	c.(196-198)ACC>GCC	p.T66A	RFFL_uc002hiq.2_5'Flank|RAD51L3_uc002hir.2_5'Flank|RAD51L3_uc010wcd.1_5'Flank|RAD51L3_uc002his.2_5'Flank|RAD51L3_uc010ctk.2_5'Flank|RAD51L3_uc010wce.1_5'Flank|RAD51L3_uc002hit.2_5'Flank|RAD51L3_uc002hiu.2_5'Flank|RAD51L3_uc010wcf.1_5'Flank|RAD51L3_uc002hiw.1_5'Flank|RAD51L3_uc002hiv.1_5'Flank|RAD51L3_uc010ctl.1_5'Flank|RAD51L3_uc010ctm.1_5'Flank	NM_017559	NP_060029	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	66										ovary(2)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)														---	---	---	---
NLE1	54475	broad.mit.edu	37	17	33467011	33467011	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33467011G>T	uc002hiy.1	-	3	265	c.237C>A	c.(235-237)TCC>TCA	p.S79S	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	79						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)																---	---	---	---
SLFN12	55106	broad.mit.edu	37	17	33738930	33738930	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33738930T>C	uc002hji.3	-	4	1541	c.1164A>G	c.(1162-1164)ATA>ATG	p.I388M	SLFN12_uc002hjj.3_Missense_Mutation_p.I388M|SLFN12_uc010cts.2_Missense_Mutation_p.I388M	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	388							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
SLFN13	146857	broad.mit.edu	37	17	33768197	33768197	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33768197T>C	uc002hjk.1	-	4	2441	c.2111A>G	c.(2110-2112)TAC>TGC	p.Y704C	SLFN13_uc010wch.1_Missense_Mutation_p.Y704C|SLFN13_uc002hjl.2_Missense_Mutation_p.Y704C|SLFN13_uc010ctt.2_Missense_Mutation_p.Y386C|SLFN13_uc002hjm.2_Missense_Mutation_p.Y373C	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	704						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
SLFN13	146857	broad.mit.edu	37	17	33770835	33770835	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33770835C>T	uc002hjk.1	-	2	1501	c.1171G>A	c.(1171-1173)GCT>ACT	p.A391T	SLFN13_uc010wch.1_Missense_Mutation_p.A391T|SLFN13_uc002hjl.2_Missense_Mutation_p.A391T|SLFN13_uc010ctt.2_Missense_Mutation_p.A73T|SLFN13_uc002hjm.2_Missense_Mutation_p.A60T	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	391						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
MMP28	79148	broad.mit.edu	37	17	34093727	34093727	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34093727T>C	uc002hjy.1	-	10	1614	c.1355A>G	c.(1354-1356)TAC>TGC	p.Y452C	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	452	Hemopexin-like 3.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
TBC1D3B	414059	broad.mit.edu	37	17	34499221	34499221	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34499221C>T	uc002hky.2	-	7	640	c.490G>A	c.(490-492)GGA>AGA	p.G164R	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	164	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
TBC1D3B	414059	broad.mit.edu	37	17	34499223	34499223	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34499223T>C	uc002hky.2	-	7	638	c.488A>G	c.(487-489)TAC>TGC	p.Y163C	uc002hla.1_5'Flank|uc002hlc.2_5'Flank	NM_001001417	NP_001001417	Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3B	163	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0		Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)														---	---	---	---
ACACA	31	broad.mit.edu	37	17	35550328	35550328	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35550328C>T	uc002hnm.2	-	36	4267	c.4076G>A	c.(4075-4077)CGA>CAA	p.R1359Q	ACACA_uc002hnk.2_Missense_Mutation_p.R1281Q|ACACA_uc002hnl.2_Missense_Mutation_p.R1301Q|ACACA_uc002hnn.2_Missense_Mutation_p.R1359Q|ACACA_uc002hno.2_Missense_Mutation_p.R1396Q|ACACA_uc010cuy.2_Missense_Mutation_p.R53Q	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1359					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
SYNRG	11276	broad.mit.edu	37	17	35880674	35880674	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35880674T>A	uc002hoa.2	-	20	3827	c.3744A>T	c.(3742-3744)GGA>GGT	p.G1248G	SYNRG_uc010wde.1_Silent_p.G1193G|SYNRG_uc010wdf.1_Silent_p.G1170G|SYNRG_uc002hoc.2_Silent_p.G1169G|SYNRG_uc002hoe.2_Silent_p.G1170G|SYNRG_uc002hod.2_Silent_p.G1125G|SYNRG_uc010wdg.1_Silent_p.G1042G|SYNRG_uc002hob.2_Silent_p.G1248G	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	1248					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2																		---	---	---	---
SYNRG	11276	broad.mit.edu	37	17	35902351	35902351	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35902351A>G	uc002hoa.2	-	15	3008	c.2925T>C	c.(2923-2925)AGT>AGC	p.S975S	SYNRG_uc010wde.1_Silent_p.S897S|SYNRG_uc010wdf.1_Silent_p.S897S|SYNRG_uc002hoc.2_Silent_p.S896S|SYNRG_uc002hoe.2_Silent_p.S897S|SYNRG_uc002hod.2_Silent_p.S852S|SYNRG_uc010wdg.1_Silent_p.S769S|SYNRG_uc002hob.2_Silent_p.S975S|SYNRG_uc002hof.2_Silent_p.S641S	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	975					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2																		---	---	---	---
GPR179	440435	broad.mit.edu	37	17	36483989	36483989	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36483989C>A	uc002hpz.2	-	11	5484	c.5463G>T	c.(5461-5463)GAG>GAT	p.E1821D		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1821	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)																---	---	---	---
MLLT6	4302	broad.mit.edu	37	17	36864113	36864113	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:36864113T>C	uc002hqi.3	+	4	355	c.342T>C	c.(340-342)GAT>GAC	p.D114D	MLLT6_uc010wdr.1_Silent_p.D114D|MLLT6_uc010cvm.1_Silent_p.D114D	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	114					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)							T	MLL	AL								---	---	---	---
CACNB1	782	broad.mit.edu	37	17	37342835	37342835	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37342835C>T	uc002hrm.1	-						CACNB1_uc002hrl.1_Intron|CACNB1_uc002hrn.2_Intron|CACNB1_uc002hro.2_Intron|CACNB1_uc002hrp.1_Intron|CACNB1_uc010web.1_Intron	NM_000723	NP_000714			calcium channel, voltage-dependent, beta 1						axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)													---	---	---	---
FBXL20	84961	broad.mit.edu	37	17	37420479	37420479	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37420479T>C	uc010wed.1	-	14	1373	c.1152A>G	c.(1150-1152)ATA>ATG	p.I384M	FBXL20_uc002hrt.2_Missense_Mutation_p.I384M|FBXL20_uc010cvu.2_Missense_Mutation_p.I352M	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	384	LRR 12.					cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)															---	---	---	---
CDK12	51755	broad.mit.edu	37	17	37627217	37627217	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37627217C>T	uc010cvv.2	+	2	1718	c.1132C>T	c.(1132-1134)CGC>TGC	p.R378C	CDK12_uc010wef.1_Missense_Mutation_p.R377C|CDK12_uc002hrw.3_Missense_Mutation_p.R378C	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	378					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19															TCGA Ovarian(9;0.13)			---	---	---	---
PNMT	5409	broad.mit.edu	37	17	37826227	37826227	+	Missense_Mutation	SNP	G	A	A	rs150323544		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37826227G>A	uc002hsi.1	+	3	656	c.434G>A	c.(433-435)CGC>CAC	p.R145H		NM_002686	NP_002677	P11086	PNMT_HUMAN	phenylethanolamine N-methyltransferase	145					catecholamine biosynthetic process|hormone biosynthetic process	cytosol	phenylethanolamine N-methyltransferase activity			ovary(1)	1	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)															---	---	---	---
MED24	9862	broad.mit.edu	37	17	38179049	38179049	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38179049T>C	uc002htt.2	-	21	2594	c.2281A>G	c.(2281-2283)ACG>GCG	p.T761A	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'Flank|MED24_uc010wer.1_Missense_Mutation_p.T96A|MED24_uc010wes.1_Missense_Mutation_p.T621A|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Missense_Mutation_p.T786A|MED24_uc002htu.2_Missense_Mutation_p.T748A|MED24_uc010cwn.2_Missense_Mutation_p.T748A|MED24_uc010weu.1_Missense_Mutation_p.T671A|MED24_uc010wev.1_Missense_Mutation_p.T711A	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	761					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)																	---	---	---	---
THRA	7067	broad.mit.edu	37	17	38240097	38240097	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38240097C>T	uc002htw.2	+	5	715	c.232C>T	c.(232-234)CGC>TGC	p.R78C	THRA_uc010cwp.1_Missense_Mutation_p.R78C|THRA_uc002htv.2_Missense_Mutation_p.R78C|THRA_uc002htx.2_Missense_Mutation_p.R78C	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	78	Nuclear receptor.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)													---	---	---	---
RAPGEFL1	51195	broad.mit.edu	37	17	38345469	38345469	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38345469G>A	uc010cwu.1	+	6	828	c.338G>A	c.(337-339)CGT>CAT	p.R113H	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.R49H	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor	319					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
WIPF2	147179	broad.mit.edu	37	17	38433330	38433330	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38433330C>T	uc002hug.1	+						WIPF2_uc002huh.1_Intron|WIPF2_uc010cww.1_Intron|WIPF2_uc002hui.1_Intron|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Intron	NM_133264	NP_573571			WIRE protein							cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3															HNSCC(43;0.11)			---	---	---	---
KRT25	147183	broad.mit.edu	37	17	38904579	38904579	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38904579T>C	uc002hve.2	-	8	1364	c.1303A>G	c.(1303-1305)ATA>GTA	p.I435V		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	435	Tail.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)																---	---	---	---
KRT27	342574	broad.mit.edu	37	17	38933833	38933833	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38933833A>G	uc002hvg.2	-	6	1165	c.1124T>C	c.(1123-1125)CTT>CCT	p.L375P		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	375	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRT28	162605	broad.mit.edu	37	17	38953472	38953472	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38953472G>A	uc002hvh.1	-	4	818	c.752C>T	c.(751-753)CCG>CTG	p.P251L		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	251	Rod.|Linker 12.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)																---	---	---	---
KRT28	162605	broad.mit.edu	37	17	38955785	38955785	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38955785A>G	uc002hvh.1	-	1	427	c.361T>C	c.(361-363)TGG>CGG	p.W121R		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	121	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)																---	---	---	---
KRT12	3859	broad.mit.edu	37	17	39019476	39019476	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39019476T>A	uc002hvk.2	-	6	1239	c.1215A>T	c.(1213-1215)GCA>GCT	p.A405A		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	405	Rod.|Coil 2.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)																---	---	---	---
KRT23	25984	broad.mit.edu	37	17	39081783	39081783	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39081783T>C	uc002hvm.1	-	7	1554	c.965A>G	c.(964-966)TAC>TGC	p.Y322C	KRT23_uc010wfl.1_Missense_Mutation_p.Y185C|KRT23_uc010cxf.1_Missense_Mutation_p.Y109C|KRT23_uc010cxg.2_Missense_Mutation_p.Y322C	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	322	Rod.|Coil 2.			Y -> N (in Ref. 1; AAK00050).		intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)																---	---	---	---
KRTAP9-8	83901	broad.mit.edu	37	17	39394461	39394461	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39394461A>G	uc002hwh.3	+	1	192	c.158A>G	c.(157-159)CAA>CGA	p.Q53R	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	53	6.|15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)															---	---	---	---
KRT33A	3883	broad.mit.edu	37	17	39504875	39504875	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39504875A>G	uc002hwk.1	-	3	485	c.448T>C	c.(448-450)TCC>CCC	p.S150P		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	150	Rod.|Coil 1B.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)																---	---	---	---
KRT33B	3884	broad.mit.edu	37	17	39521180	39521180	+	Missense_Mutation	SNP	G	T	T	rs142638263	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39521180G>T	uc002hwl.2	-	6	993	c.948C>A	c.(946-948)AGC>AGA	p.S316R		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	316	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)																---	---	---	---
KRT33B	3884	broad.mit.edu	37	17	39521262	39521262	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39521262A>G	uc002hwl.2	-							NM_002279	NP_002270			type I hair keratin 3B							intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)																---	---	---	---
KRT32	3882	broad.mit.edu	37	17	39616434	39616434	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39616434G>A	uc002hwr.2	-	7	1336	c.1275C>T	c.(1273-1275)TGC>TGT	p.C425C		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	425	Tail.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRT32	3882	broad.mit.edu	37	17	39622129	39622129	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39622129G>T	uc002hwr.2	-	3	665	c.604C>A	c.(604-606)CTG>ATG	p.L202M		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	202	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)																---	---	---	---
KRT13	3860	broad.mit.edu	37	17	39661386	39661386	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39661386C>T	uc002hwu.1	-	1	480	c.417G>A	c.(415-417)TGG>TGA	p.W139*	KRT13_uc002hwv.1_Nonsense_Mutation_p.W139*|KRT13_uc002hww.2_Nonsense_Mutation_p.W32*|KRT13_uc010wfr.1_Nonsense_Mutation_p.W32*|KRT13_uc010cxo.2_Nonsense_Mutation_p.W139*|KRT13_uc002hwx.1_Nonsense_Mutation_p.W127*	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	139	Coil 1A.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)																---	---	---	---
HAP1	9001	broad.mit.edu	37	17	39883656	39883656	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39883656T>C	uc002hxm.1	-	9	1337	c.1325A>G	c.(1324-1326)GAT>GGT	p.D442G	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Intron|HAP1_uc002hxo.1_Intron|HAP1_uc002hxp.1_Intron	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	442	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)															---	---	---	---
JUP	3728	broad.mit.edu	37	17	39913734	39913734	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39913734T>C	uc002hxq.2	-	12	2256	c.1979A>G	c.(1978-1980)TAC>TGC	p.Y660C	JUP_uc010wfs.1_Intron|JUP_uc002hxr.2_Missense_Mutation_p.Y660C|JUP_uc002hxs.2_Missense_Mutation_p.Y660C	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	660					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)														---	---	---	---
FKBP10	60681	broad.mit.edu	37	17	39973321	39973321	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39973321A>G	uc002hxv.2	+	2	582	c.257A>G	c.(256-258)AAC>AGC	p.N86S	FKBP10_uc002hxw.1_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	86	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)														---	---	---	---
FKBP10	60681	broad.mit.edu	37	17	39973411	39973411	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39973411G>A	uc002hxv.2	+	2	672	c.347G>A	c.(346-348)CGC>CAC	p.R116H	FKBP10_uc002hxw.1_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	116	PPIase FKBP-type 1.		Missing (in OI6).		protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)														---	---	---	---
ACLY	47	broad.mit.edu	37	17	40070067	40070067	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40070067A>G	uc002hyg.2	-	2	223	c.60T>C	c.(58-60)TGT>TGC	p.C20C	ACLY_uc002hyh.2_Silent_p.C20C|ACLY_uc002hyi.2_Silent_p.C74C|ACLY_uc010wfx.1_Silent_p.C74C|ACLY_uc010wfy.1_Silent_p.C20C	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	20					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)																---	---	---	---
DHX58	79132	broad.mit.edu	37	17	40263478	40263478	+	Missense_Mutation	SNP	C	T	T	rs143989971	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40263478C>T	uc002hyw.3	-	4	429	c.206G>A	c.(205-207)CGC>CAC	p.R69H	DHX58_uc002hyv.3_RNA|DHX58_uc010wgf.1_Missense_Mutation_p.R62H	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	69	Helicase ATP-binding.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)														---	---	---	---
PSMC3IP	29893	broad.mit.edu	37	17	40726185	40726185	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40726185T>C	uc002iai.2	-	4	312	c.269A>G	c.(268-270)GAT>GGT	p.D90G	PSMC3IP_uc002iaj.2_Missense_Mutation_p.D27G|PSMC3IP_uc002iak.2_Missense_Mutation_p.D90G|PSMC3IP_uc010wgn.1_Missense_Mutation_p.D11G|PSMC3IP_uc010wgo.1_Intron|PSMC3IP_uc010wgp.1_RNA	NM_016556	NP_057640	Q9P2W1	HOP2_HUMAN	PSMC3 interacting protein isoform 2	90					DNA recombination|meiosis	nucleus	DNA binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(22;0.00426)|Breast(137;0.00116)|all_epithelial(22;0.0395)		BRCA - Breast invasive adenocarcinoma(366;0.13)														---	---	---	---
TUBG2	27175	broad.mit.edu	37	17	40817819	40817819	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40817819T>C	uc010wgr.1	+	8	1073	c.817T>C	c.(817-819)TAC>CAC	p.Y273H	TUBG2_uc002iaq.2_Missense_Mutation_p.Y115H|TUBG2_uc002iar.2_Missense_Mutation_p.Y120H|TUBG2_uc002ias.2_Missense_Mutation_p.Y115H|TUBG2_uc002iap.2_Missense_Mutation_p.Y120H	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	273					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)														---	---	---	---
PLEKHH3	79990	broad.mit.edu	37	17	40821468	40821468	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40821468G>A	uc002iau.2	-	12	2652	c.2185C>T	c.(2185-2187)CTC>TTC	p.L729F	PLEKHH3_uc010cyl.1_Intron|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Missense_Mutation_p.L90F|PLEKHH3_uc002iaw.2_3'UTR	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	729	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)														---	---	---	---
CNTNAP1	8506	broad.mit.edu	37	17	40844011	40844011	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40844011T>C	uc002iay.2	+	16	2746	c.2530_splice	c.e16+2	p.T844_splice	CNTNAP1_uc010wgs.1_Splice_Site	NM_003632	NP_003623			contactin associated protein 1 precursor						axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)														---	---	---	---
WNK4	65266	broad.mit.edu	37	17	40937399	40937399	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40937399A>G	uc002ibj.2	+	6	1396	c.1375A>G	c.(1375-1377)ATG>GTG	p.M459V	WNK4_uc010wgx.1_Missense_Mutation_p.M123V|WNK4_uc002ibk.1_Missense_Mutation_p.M231V|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	459					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)														---	---	---	---
AOC2	314	broad.mit.edu	37	17	40997488	40997488	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40997488T>C	uc002ibu.2	+	1	880	c.845T>C	c.(844-846)GTG>GCG	p.V282A	AOC2_uc002ibt.2_Missense_Mutation_p.V282A	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	282					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)														---	---	---	---
IFI35	3430	broad.mit.edu	37	17	41165193	41165193	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41165193A>G	uc010whj.1	+	3	446	c.250A>G	c.(250-252)ACC>GCC	p.T84A		NM_005533	NP_005524	P80217	IN35_HUMAN	interferon-induced protein 35	84					response to virus|type I interferon-mediated signaling pathway	nucleus	protein binding			ovary(1)	1		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.157)														---	---	---	---
MPP3	4356	broad.mit.edu	37	17	41907103	41907103	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41907103C>T	uc002iei.3	-	7	526	c.360G>A	c.(358-360)CCG>CCA	p.P120P	MPP3_uc002ieh.2_Silent_p.P145P|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Silent_p.P120P|MPP3_uc010wik.1_Silent_p.P145P|MPP3_uc010czj.1_3'UTR	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	120					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)														---	---	---	---
MPP3	4356	broad.mit.edu	37	17	41907449	41907449	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41907449G>A	uc002iei.3	-	6	415	c.249C>T	c.(247-249)TCC>TCT	p.S83S	MPP3_uc002ieh.2_Silent_p.S108S|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Silent_p.S83S|MPP3_uc010wik.1_Silent_p.S108S|MPP3_uc010czj.1_Silent_p.S83S	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	83	L27 2.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)														---	---	---	---
ATXN7L3	56970	broad.mit.edu	37	17	42271691	42271691	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42271691C>G	uc002iga.2	-	12	1075	c.984G>C	c.(982-984)AAG>AAC	p.K328N	ATXN7L3_uc010wiv.1_Missense_Mutation_p.K110N|ATXN7L3_uc002ifz.2_Missense_Mutation_p.K335N	NM_001098833	NP_001092303	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3 isoform b	328					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)														---	---	---	---
SLC4A1	6521	broad.mit.edu	37	17	42334882	42334882	+	Missense_Mutation	SNP	C	T	T	rs28931584		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42334882C>T	uc002igf.3	-	13	1611	c.1462G>A	c.(1462-1464)GTG>ATG	p.V488M	SLC4A1_uc002igg.3_Missense_Mutation_p.V488M	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	488	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)														---	---	---	---
SLC25A39	51629	broad.mit.edu	37	17	42397576	42397576	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42397576C>T	uc002ign.2	-	11	1106	c.952G>A	c.(952-954)GGA>AGA	p.G318R	SLC25A39_uc002igm.2_Missense_Mutation_p.G310R|SLC25A39_uc002igo.2_Missense_Mutation_p.G310R|SLC25A39_uc010wiw.1_Missense_Mutation_p.G295R|SLC25A39_uc010czu.2_Missense_Mutation_p.G186R	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	318	Solcar 3.|Helical; Name=6; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)														---	---	---	---
ITGA2B	3674	broad.mit.edu	37	17	42457166	42457166	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42457166C>T	uc002igt.1	-	18	1801	c.1769G>A	c.(1768-1770)CGG>CAG	p.R590Q	ITGA2B_uc002igu.1_Missense_Mutation_p.R71Q	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	590	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)													---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42476888	42476888	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42476888G>A	uc002igw.1	-	8	2621	c.2557C>T	c.(2557-2559)CGC>TGC	p.R853C	GPATCH8_uc002igv.1_Missense_Mutation_p.R775C|GPATCH8_uc010wiz.1_Missense_Mutation_p.R775C	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	853	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42477017	42477017	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42477017G>A	uc002igw.1	-	8	2492	c.2428C>T	c.(2428-2430)CGG>TGG	p.R810W	GPATCH8_uc002igv.1_Missense_Mutation_p.R732W|GPATCH8_uc010wiz.1_Missense_Mutation_p.R732W	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	810	Ser-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
C17orf104	284071	broad.mit.edu	37	17	42745051	42745051	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42745051A>G	uc010czv.2	+	5	1772	c.1772A>G	c.(1771-1773)AAC>AGC	p.N591S	C17orf104_uc002igy.1_Missense_Mutation_p.N425S|C17orf104_uc002igz.3_Missense_Mutation_p.N425S|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Missense_Mutation_p.N425S	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	591										central_nervous_system(1)	1																		---	---	---	---
EFTUD2	9343	broad.mit.edu	37	17	42940176	42940176	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42940176C>T	uc002ihn.2	-	16	1773	c.1512G>A	c.(1510-1512)GGG>GGA	p.G504G	EFTUD2_uc010wje.1_Silent_p.G469G|EFTUD2_uc010wjf.1_Silent_p.G494G	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	504						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)																---	---	---	---
HEXIM1	10614	broad.mit.edu	37	17	43227060	43227060	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43227060A>G	uc002iig.2	+	1	2377	c.503A>G	c.(502-504)TAC>TGC	p.Y168C		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	168	Basic region; mediates nuclear localization and interaction with 7SK snRNA and NR3C1.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1																OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
HEXIM2	124790	broad.mit.edu	37	17	43246699	43246699	+	Silent	SNP	C	T	T	rs150581722		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43246699C>T	uc002iih.1	+	4	623	c.384C>T	c.(382-384)CGC>CGT	p.R128R	HEXIM2_uc010daf.1_Silent_p.R150R|HEXIM2_uc002iii.1_Silent_p.R128R|HEXIM2_uc002iij.1_Silent_p.R128R|uc002iik.1_RNA	NM_144608	NP_653209	Q96MH2	HEXI2_HUMAN	hexamthylene bis-acetamide inducible 2	128					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding				0																		---	---	---	---
ARHGAP27	201176	broad.mit.edu	37	17	43480071	43480071	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43480071G>A	uc002iix.2	-						ARHGAP27_uc010dak.2_Intron|ARHGAP27_uc010wjl.1_Intron	NM_199282	NP_954976			Rho GTPase activating protein 27 isoform a						positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)																	---	---	---	---
MAPT	4137	broad.mit.edu	37	17	44039745	44039745	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44039745C>T	uc002ijr.3	+	2	362	c.42C>T	c.(40-42)CAC>CAT	p.H14H	MAPT_uc010dau.2_Silent_p.H14H|MAPT_uc002ijs.3_Silent_p.H14H|MAPT_uc002ijx.3_Silent_p.H14H|MAPT_uc002ijt.3_Silent_p.H14H|MAPT_uc002iju.3_Silent_p.H14H|MAPT_uc002ijv.3_Silent_p.H14H	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	14					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)																---	---	---	---
WNT3	7473	broad.mit.edu	37	17	44845745	44845745	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44845745A>G	uc002ikv.2	-	4	1128	c.1009T>C	c.(1009-1011)TGC>CGC	p.C337R		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	337					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)															---	---	---	---
CDC27	996	broad.mit.edu	37	17	45199935	45199935	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45199935G>A	uc002ild.3	-	18	2394	c.2267C>T	c.(2266-2268)GCC>GTC	p.A756V	CDC27_uc002ile.3_Missense_Mutation_p.A762V|CDC27_uc002ilf.3_Missense_Mutation_p.A755V|CDC27_uc010wkp.1_Missense_Mutation_p.A695V|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	756	TPR 9.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5																		---	---	---	---
C17orf57	124989	broad.mit.edu	37	17	45425174	45425174	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45425174C>T	uc002iln.2	+	9	929	c.518C>T	c.(517-519)GCA>GTA	p.A173V	C17orf57_uc002ilm.2_Intron|C17orf57_uc002ill.1_Intron|C17orf57_uc010daz.1_Intron	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	173							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
OSBPL7	114881	broad.mit.edu	37	17	45897450	45897450	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45897450A>G	uc002ilx.1	-	3	291	c.88T>C	c.(88-90)TGG>CGG	p.W30R		NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	30					lipid transport		lipid binding				0																		---	---	---	---
SCRN2	90507	broad.mit.edu	37	17	45917722	45917722	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45917722A>G	uc002imd.2	-	3	317	c.191T>C	c.(190-192)GTG>GCG	p.V64A	SCRN2_uc002imc.2_Missense_Mutation_p.V72A|SCRN2_uc002imf.2_Missense_Mutation_p.V64A|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	64					proteolysis		dipeptidase activity			ovary(1)	1																		---	---	---	---
CDK5RAP3	80279	broad.mit.edu	37	17	46058547	46058547	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46058547T>C	uc002imr.2	+	13	1386	c.1302T>C	c.(1300-1302)ACT>ACC	p.T434T	CDK5RAP3_uc010wlc.1_Silent_p.T454T|CDK5RAP3_uc002imq.1_Silent_p.T209T|CDK5RAP3_uc002imu.2_Silent_p.T278T|CDK5RAP3_uc002ims.2_Silent_p.T347T|CDK5RAP3_uc002imv.2_Silent_p.T278T|CDK5RAP3_uc002imw.2_Silent_p.T276T|CDK5RAP3_uc002imx.2_Silent_p.T209T	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	434					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0																		---	---	---	---
HOXB2	3212	broad.mit.edu	37	17	46621965	46621965	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46621965G>A	uc002inm.2	-	1	429	c.309C>T	c.(307-309)TCC>TCT	p.S103S		NM_002145	NP_002136	P14652	HXB2_HUMAN	homeobox B2	103					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
SNF8	11267	broad.mit.edu	37	17	47022068	47022068	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47022068G>A	uc002ioj.2	-	1	87	c.29C>T	c.(28-30)GCC>GTC	p.A10V	SNF8_uc002iok.2_Missense_Mutation_p.A10V	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	10					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0																		---	---	---	---
ZNF652	22834	broad.mit.edu	37	17	47394489	47394489	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47394489G>A	uc002iov.3	-	2	1063	c.599C>T	c.(598-600)GCA>GTA	p.A200V	ZNF652_uc002iow.2_Missense_Mutation_p.A200V|ZNF652_uc002iou.3_Intron	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)															---	---	---	---
SLC35B1	10237	broad.mit.edu	37	17	47781497	47781497	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47781497T>C	uc002iph.1	-	6	707	c.620A>G	c.(619-621)AAC>AGC	p.N207S	SLC35B1_uc002ipi.1_Missense_Mutation_p.N140S|SLC35B1_uc002ipj.1_Missense_Mutation_p.N83S|SLC35B1_uc010wly.1_Missense_Mutation_p.N207S	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	207						endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0																		---	---	---	---
ITGA3	3675	broad.mit.edu	37	17	48158769	48158769	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48158769G>A	uc010dbl.2	+	23	3380	c.2916G>A	c.(2914-2916)ACG>ACA	p.T972T	ITGA3_uc010dbm.2_Silent_p.T972T	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	972	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
LRRC59	55379	broad.mit.edu	37	17	48462559	48462559	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48462559C>T	uc002iqt.2	-	6	750	c.596G>A	c.(595-597)CGG>CAG	p.R199Q		NM_018509	NP_060979	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	199	Potential.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			central_nervous_system(1)	1	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)															---	---	---	---
RSAD1	55316	broad.mit.edu	37	17	48559747	48559747	+	Missense_Mutation	SNP	A	G	G	rs140459309	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48559747A>G	uc002iqw.1	+	4	826	c.770A>G	c.(769-771)TAC>TGC	p.Y257C	RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	257					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)													OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ABCC3	8714	broad.mit.edu	37	17	48746229	48746229	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48746229T>C	uc002isl.2	+	15	1966	c.1886T>C	c.(1885-1887)ATA>ACA	p.I629T		NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	629	ABC transporter 1.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)													---	---	---	---
ABCC3	8714	broad.mit.edu	37	17	48765057	48765057	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48765057G>A	uc002isl.2	+	30	4521	c.4441G>A	c.(4441-4443)GCA>ACA	p.A1481T	ABCC3_uc002isn.2_Missense_Mutation_p.A235T	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1481	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)													---	---	---	---
WFIKKN2	124857	broad.mit.edu	37	17	48917518	48917518	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48917518G>A	uc002isv.3	+	2	1563	c.869G>A	c.(868-870)CGG>CAG	p.R290Q	WFIKKN2_uc010dbu.2_Missense_Mutation_p.R197Q	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	290	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)															---	---	---	---
SPAG9	9043	broad.mit.edu	37	17	49074005	49074005	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49074005C>T	uc002itc.2	-	16	2098	c.1889G>A	c.(1888-1890)CGT>CAT	p.R630H	SPAG9_uc002itb.2_Missense_Mutation_p.R616H|SPAG9_uc002itd.2_Missense_Mutation_p.R620H|SPAG9_uc002itf.2_Missense_Mutation_p.R451H|SPAG9_uc002ita.2_Missense_Mutation_p.R473H|SPAG9_uc002ite.2_Missense_Mutation_p.R460H	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	630					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)															---	---	---	---
NME1-NME2	654364	broad.mit.edu	37	17	49245649	49245649	+	Missense_Mutation	SNP	G	A	A	rs138826459		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49245649G>A	uc002itk.2	+	7	846	c.593G>A	c.(592-594)CGA>CAA	p.R198Q	NME1-NME2_uc002itj.2_Missense_Mutation_p.R173Q|NME2_uc002itl.2_Missense_Mutation_p.R58Q|NME2_uc002itm.2_Missense_Mutation_p.R58Q|NME2_uc002itn.2_Missense_Mutation_p.R58Q|NME2_uc002ito.2_Missense_Mutation_p.R58Q	NM_002512	NP_002503	P22392	NDKB_HUMAN	nucleoside diphosphate kinase B	58	Interaction with AKAP13.				cell adhesion|CTP biosynthetic process|GTP biosynthetic process|negative regulation of apoptosis|nucleobase, nucleoside and nucleotide interconversion|positive regulation of epithelial cell proliferation|positive regulation of keratinocyte differentiation|UTP biosynthetic process	cytosol|lamellipodium|nucleus|ruffle	ATP binding|DNA binding|metal ion binding|nucleoside diphosphate kinase activity|protein binding|protein histidine kinase activity|sequence-specific DNA binding transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)															---	---	---	---
MBTD1	54799	broad.mit.edu	37	17	49284306	49284306	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49284306T>C	uc002itr.3	-	7	891	c.547A>G	c.(547-549)ACA>GCA	p.T183A	MBTD1_uc002itp.3_Missense_Mutation_p.T19A|MBTD1_uc002itq.3_Missense_Mutation_p.T183A	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	mbt domain containing 1	183	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)															---	---	---	---
CA10	56934	broad.mit.edu	37	17	50008372	50008372	+	Missense_Mutation	SNP	C	T	T	rs148839711	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:50008372C>T	uc002itw.3	-	3	1243	c.257G>A	c.(256-258)CGC>CAC	p.R86H	CA10_uc002itv.3_Missense_Mutation_p.R92H|CA10_uc002itx.3_Missense_Mutation_p.R86H|CA10_uc002ity.3_Missense_Mutation_p.R86H|CA10_uc002itz.2_Missense_Mutation_p.R86H	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	86					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)															---	---	---	---
KIF2B	84643	broad.mit.edu	37	17	51900667	51900667	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:51900667G>A	uc002iua.2	+	1	429	c.273G>A	c.(271-273)CCG>CCA	p.P91P		NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	91					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8																		---	---	---	---
TOM1L1	10040	broad.mit.edu	37	17	52993102	52993102	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:52993102T>C	uc002iud.2	+						TOM1L1_uc002iub.2_Intron|TOM1L1_uc002iuc.2_Intron|TOM1L1_uc010dca.1_Intron|TOM1L1_uc010wnb.1_Intron|TOM1L1_uc010wnc.1_Intron|TOM1L1_uc010dbz.2_Intron|TOM1L1_uc010wnd.1_Intron|TOM1L1_uc010dcb.1_Intron	NM_005486	NP_005477			target of myb1-like 1						intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1																		---	---	---	---
STXBP4	252983	broad.mit.edu	37	17	53078195	53078195	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:53078195A>G	uc002iuf.1	+	7	732	c.525A>G	c.(523-525)GTA>GTG	p.V175V	STXBP4_uc010dcc.1_Silent_p.V100V|STXBP4_uc010dcd.1_Silent_p.V175V	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	175						cytoplasm	calcium ion binding			ovary(1)	1																		---	---	---	---
DGKE	8526	broad.mit.edu	37	17	54912353	54912353	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54912353A>G	uc002iur.2	+	2	377	c.197A>G	c.(196-198)GAC>GGC	p.D66G	DGKE_uc002ius.1_Missense_Mutation_p.D66G|C17orf67_uc002iuq.2_5'Flank	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	66	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)																	---	---	---	---
TRIM25	7706	broad.mit.edu	37	17	54981735	54981735	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54981735C>T	uc002iut.2	-	3	868	c.808G>A	c.(808-810)GTC>ATC	p.V270I	TRIM25_uc010dcj.2_Missense_Mutation_p.V62I	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	270	Interaction with influenza A virus NS1.|Potential.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)																	---	---	---	---
VEZF1	7716	broad.mit.edu	37	17	56060228	56060228	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56060228T>C	uc002ivf.1	-	2	703	c.560A>G	c.(559-561)TAC>TGC	p.Y187C	VEZF1_uc010dcn.1_Missense_Mutation_p.Y31C	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	187	C2H2-type 2.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
MKS1	54903	broad.mit.edu	37	17	56291683	56291683	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56291683T>C	uc002ivr.1	-	6	656	c.581A>G	c.(580-582)AAC>AGC	p.N194S	MKS1_uc010wnq.1_5'UTR|MKS1_uc002ivs.1_Missense_Mutation_p.N194S	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	194					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1																		---	---	---	---
BZRAP1	9256	broad.mit.edu	37	17	56385040	56385040	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56385040C>T	uc002ivx.3	-	24	5786	c.4915G>A	c.(4915-4917)GTG>ATG	p.V1639M	BZRAP1_uc002ivv.2_5'Flank|BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.V1579M|BZRAP1_uc010wnt.1_Missense_Mutation_p.V1639M	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1639	SH3 2.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
RNF43	54894	broad.mit.edu	37	17	56492679	56492679	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56492679A>G	uc002iwf.2	-						RNF43_uc010wnv.1_Intron|RNF43_uc002iwh.3_Intron|RNF43_uc002iwg.3_Intron|RNF43_uc010dcw.2_Intron	NM_017763	NP_060233			ring finger protein 43 precursor							endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TEX14	56155	broad.mit.edu	37	17	56676460	56676460	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56676460C>A	uc010dcz.1	-	14	2382	c.2264G>T	c.(2263-2265)AGG>ATG	p.R755M	TEX14_uc002iwr.1_Missense_Mutation_p.R749M|TEX14_uc002iws.1_Missense_Mutation_p.R749M|TEX14_uc010dda.1_Missense_Mutation_p.R529M	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	755	Potential.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
TEX14	56155	broad.mit.edu	37	17	56738526	56738526	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56738526C>T	uc010dcz.1	-						TEX14_uc002iwr.1_Intron|TEX14_uc002iws.1_Intron|TEX14_uc010dda.1_Intron|TEX14_uc010wnz.1_Silent_p.T145T	NM_198393	NP_938207			testis expressed sequence 14 isoform a							cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
PPM1E	22843	broad.mit.edu	37	17	57057738	57057738	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57057738C>A	uc002iwx.2	+	7	1741	c.1614C>A	c.(1612-1614)GCC>GCA	p.A538A	PPM1E_uc010ddd.2_Silent_p.A301A	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	547					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)															---	---	---	---
CLTC	1213	broad.mit.edu	37	17	57759679	57759679	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57759679G>A	uc002ixq.1	+	22	3933	c.3490G>A	c.(3490-3492)GCT>ACT	p.A1164T	CLTC_uc002ixp.2_Missense_Mutation_p.A1164T|CLTC_uc002ixr.1_Missense_Mutation_p.A1168T	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	1164	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)							T	ALK|TFE3	ALCL|renal 								---	---	---	---
PTRH2	51651	broad.mit.edu	37	17	57775295	57775295	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57775295A>G	uc002ixt.2	-	2	170	c.45T>C	c.(43-45)AGT>AGC	p.S15S	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	15					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)																	---	---	---	---
HEATR6	63897	broad.mit.edu	37	17	58137347	58137347	+	Silent	SNP	G	A	A	rs61752323		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58137347G>A	uc002iyk.1	-	10	1544	c.1527C>T	c.(1525-1527)TCC>TCT	p.S509S	HEATR6_uc010ddk.1_Silent_p.S48S|HEATR6_uc010wos.1_Silent_p.S341S	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	509							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)															---	---	---	---
CA4	762	broad.mit.edu	37	17	58234823	58234823	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58234823G>A	uc002iym.3	+	4	398	c.304G>A	c.(304-306)GGA>AGA	p.G102R	CA4_uc010wou.1_Intron	NM_000717	NP_000708	P22748	CAH4_HUMAN	carbonic anhydrase IV precursor	102					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)													---	---	---	---
USP32	84669	broad.mit.edu	37	17	58286039	58286039	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58286039T>C	uc002iyo.1	-	23	3035	c.2749A>G	c.(2749-2751)AGT>GGT	p.S917G	USP32_uc002iyn.1_Missense_Mutation_p.S587G	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	917					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
USP32	84669	broad.mit.edu	37	17	58297062	58297062	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58297062C>T	uc002iyo.1	-	16	2122	c.1836G>A	c.(1834-1836)CGG>CGA	p.R612R	USP32_uc002iyn.1_Silent_p.R282R	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	612					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
PPM1D	8493	broad.mit.edu	37	17	58734051	58734051	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58734051C>T	uc002iyt.1	+	5	1331	c.1109C>T	c.(1108-1110)GCC>GTC	p.A370V	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	370	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)															---	---	---	---
TBX2	6909	broad.mit.edu	37	17	59479272	59479272	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59479272A>G	uc010wox.1	+	2	904	c.623A>G	c.(622-624)AAG>AGG	p.K208R	TBX2_uc002ize.2_Missense_Mutation_p.K198R|TBX2_uc002izg.2_Missense_Mutation_p.K54R	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	208	T-box.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0																		---	---	---	---
TBX4	9496	broad.mit.edu	37	17	59560530	59560530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59560530G>A	uc002izi.2	+	8	1336	c.1291G>A	c.(1291-1293)GTG>ATG	p.V431M	TBX4_uc010ddo.2_Missense_Mutation_p.V432M|TBX4_uc010woy.1_Missense_Mutation_p.V432M	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	431					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
INTS2	57508	broad.mit.edu	37	17	59999076	59999076	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59999076A>G	uc002izn.2	-						INTS2_uc002izm.2_Intron	NM_020748	NP_065799			integrator complex subunit 2						snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3																		---	---	---	---
MED13	9969	broad.mit.edu	37	17	60033126	60033126	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60033126A>G	uc002izo.2	-	25	5774	c.5697T>C	c.(5695-5697)TGT>TGC	p.C1899C		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1899					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
MED13	9969	broad.mit.edu	37	17	60072676	60072676	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60072676T>C	uc002izo.2	-	10	2095	c.2018A>G	c.(2017-2019)CAG>CGG	p.Q673R		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	673					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
MARCH10	162333	broad.mit.edu	37	17	60814662	60814662	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60814662A>G	uc010ddr.2	-	6	805	c.567T>C	c.(565-567)TGT>TGC	p.C189C	MARCH10_uc002jag.3_Silent_p.C189C|MARCH10_uc010dds.2_Silent_p.C227C|MARCH10_uc002jah.2_Silent_p.C188C|uc002jaj.1_RNA|uc002jak.2_RNA	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	189							ligase activity|zinc ion binding				0																		---	---	---	---
ACE	1636	broad.mit.edu	37	17	61573878	61573878	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61573878G>A	uc002jau.1	+	23	3525	c.3503_splice	c.e23+1	p.A1168_splice	ACE_uc002jav.1_Splice_Site_p.A594_splice|ACE_uc010ddv.1_Splice_Site_p.A395_splice|ACE_uc010wpj.1_Intron|ACE_uc002jaw.1_Splice_Site|ACE_uc010wpk.1_Intron	NM_000789	NP_000780			angiotensin I converting enzyme 1 isoform 1						arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)													---	---	---	---
MAP3K3	4215	broad.mit.edu	37	17	61770979	61770979	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61770979G>A	uc002jbg.2	+	16	2042	c.1723G>A	c.(1723-1725)GCC>ACC	p.A575T	MAP3K3_uc002jbe.2_Missense_Mutation_p.A606T|MAP3K3_uc002jbf.2_Missense_Mutation_p.A606T|MAP3K3_uc002jbh.2_Missense_Mutation_p.A602T|MAP3K3_uc010wpo.1_Missense_Mutation_p.A490T|MAP3K3_uc010wpp.1_Missense_Mutation_p.A571T	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	575	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6																		---	---	---	---
LIMD2	80774	broad.mit.edu	37	17	61776415	61776415	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61776415G>A	uc002jbj.3	-	3	235	c.57C>T	c.(55-57)GGC>GGT	p.G19G	LIMD2_uc002jbk.3_Missense_Mutation_p.R21W|LIMD2_uc002jbl.3_Silent_p.G19G	NM_030576	NP_085053	Q9BT23	LIMD2_HUMAN	LIM domain containing 2	19							zinc ion binding				0																		---	---	---	---
STRADA	92335	broad.mit.edu	37	17	61781717	61781717	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61781717G>A	uc002jbm.2	-	11	1243	c.1084C>T	c.(1084-1086)CGC>TGC	p.R362C	STRADA_uc002jbn.2_Missense_Mutation_p.R304C|STRADA_uc002jbo.2_Missense_Mutation_p.R325C|STRADA_uc002jbp.2_Missense_Mutation_p.R325C|STRADA_uc002jbq.2_Missense_Mutation_p.R304C|STRADA_uc010wpq.1_Intron|STRADA_uc010wpr.1_Intron|STRADA_uc010ddw.2_Missense_Mutation_p.R333C|STRADA_uc002jbr.2_3'UTR	NM_001003787	NP_001003787	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha isoform 1	362	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			ovary(1)	1																		---	---	---	---
SCN4A	6329	broad.mit.edu	37	17	62018253	62018253	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62018253C>T	uc002jds.1	-	24	5466	c.5389G>A	c.(5389-5391)GAG>AAG	p.E1797K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1797					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)													---	---	---	---
CCDC45	90799	broad.mit.edu	37	17	62528147	62528147	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62528147A>G	uc002jem.2	+						CCDC45_uc002jen.2_Intron|CCDC45_uc010wqb.1_Intron|CCDC45_uc002jeo.1_5'Flank	NM_138363	NP_612372			coiled-coil domain containing 45							centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)															---	---	---	---
LRRC37A3	374819	broad.mit.edu	37	17	62856350	62856350	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62856350T>A	uc002jey.2	-	11	4445	c.3914A>T	c.(3913-3915)TAC>TTC	p.Y1305F	LRRC37A3_uc010wqg.1_Missense_Mutation_p.Y423F|LRRC37A3_uc002jex.1_Missense_Mutation_p.Y282F|LRRC37A3_uc010wqf.1_Missense_Mutation_p.Y343F|LRRC37A3_uc010dek.1_Missense_Mutation_p.Y311F	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1305	Extracellular (Potential).					integral to membrane					0																		---	---	---	---
RGS9	8787	broad.mit.edu	37	17	63221143	63221143	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63221143C>T	uc002jfe.2	+	18	1541	c.1431C>T	c.(1429-1431)AGC>AGT	p.S477S	RGS9_uc010dem.2_Silent_p.S474S|RGS9_uc002jfd.2_Silent_p.S474S|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Silent_p.S248S	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	477					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4																		---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65124796	65124796	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65124796T>C	uc010wqk.1	-	24	3548	c.3361A>G	c.(3361-3363)ACC>GCC	p.T1121A	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.T1120A	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65124955	65124955	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65124955A>G	uc010wqk.1	-	24	3389	c.3202T>C	c.(3202-3204)TTT>CTT	p.F1068L	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.F1067L	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65184543	65184543	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65184543C>T	uc010wqk.1	-	12	1241	c.1054G>A	c.(1054-1056)GCA>ACA	p.A352T	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.A352T	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
PSMD12	5718	broad.mit.edu	37	17	65362568	65362568	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65362568G>A	uc002jfy.2	-	1	154	c.68C>T	c.(67-69)ACG>ATG	p.T23M	PSMD12_uc002jga.2_Missense_Mutation_p.T23M|PSMD12_uc002jfz.2_Translation_Start_Site|PSMD12_uc010det.1_Missense_Mutation_p.T23M	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	23					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)																	---	---	---	---
NOL11	25926	broad.mit.edu	37	17	65720235	65720235	+	Missense_Mutation	SNP	G	A	A	rs148391618		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65720235G>A	uc002jgd.1	+	6	593	c.590G>A	c.(589-591)GGA>GAA	p.G197E	NOL11_uc010wql.1_Missense_Mutation_p.G15E|NOL11_uc010deu.1_5'UTR	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	197						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65889599	65889599	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65889599C>T	uc002jgf.2	+	6	2230	c.2169C>T	c.(2167-2169)CGC>CGT	p.R723R	BPTF_uc002jge.2_Silent_p.R849R|BPTF_uc010wqm.1_Silent_p.R786R	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	849	Interaction with MAZ.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
FAM20A	54757	broad.mit.edu	37	17	66538220	66538220	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66538220A>G	uc002jho.2	-	7	1303	c.1015T>C	c.(1015-1017)TCC>CCC	p.S339P	FAM20A_uc010wqp.1_Missense_Mutation_p.S201P|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Silent_p.V41V	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	339						extracellular region					0	Breast(10;1.64e-13)																	---	---	---	---
ABCA8	10351	broad.mit.edu	37	17	66925370	66925370	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66925370A>G	uc002jhp.2	-	8	1124	c.945T>C	c.(943-945)GCT>GCC	p.A315A	ABCA8_uc002jhq.2_Silent_p.A315A|ABCA8_uc010wqq.1_Silent_p.A315A|ABCA8_uc010wqr.1_Silent_p.A254A|ABCA8_uc002jhr.2_Silent_p.A315A	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	315	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67150037	67150037	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67150037C>A	uc010dfa.1	-	33	4779	c.3900G>T	c.(3898-3900)GAG>GAT	p.E1300D	ABCA10_uc010wqs.1_Missense_Mutation_p.E292D|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1300	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67178813	67178813	+	Intron	SNP	T	A	A	rs111968521	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67178813T>A	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfb.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67189626	67189626	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67189626T>C	uc010dfa.1	-						ABCA10_uc010wqt.1_Intron|ABCA10_uc010dfb.1_Intron	NM_080282	NP_525021			ATP-binding cassette, sub-family A, member 10						transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
ABCA10	10349	broad.mit.edu	37	17	67215708	67215708	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67215708C>T	uc010dfa.1	-	7	1387	c.508G>A	c.(508-510)GGT>AGT	p.G170S	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfc.1_Missense_Mutation_p.G62S	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	170					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)																	---	---	---	---
GPRC5C	55890	broad.mit.edu	37	17	72428192	72428192	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72428192C>T	uc002jkp.2	+	1	526	c.15C>T	c.(13-15)GGC>GGT	p.G5G	GPRC5C_uc002jkq.2_Silent_p.G5G|GPRC5C_uc002jkr.2_5'Flank	NM_022036	NP_071319	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	Error:Variant_position_missing_in_Q9NQ84_after_alignment						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
CD300LF	146722	broad.mit.edu	37	17	72691997	72691997	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72691997A>G	uc002jlg.2	-	6	687	c.584T>C	c.(583-585)GTA>GCA	p.V195A	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Missense_Mutation_p.V198A|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_Silent_p.G210G|CD300LF_uc002jli.2_Silent_p.G160G|CD300LF_uc010wra.1_Missense_Mutation_p.V210A|CD300LF_uc002jlj.1_Silent_p.G205G	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	195	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
TMEM104	54868	broad.mit.edu	37	17	72832138	72832138	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72832138C>T	uc002jls.3	+	10	965	c.803C>T	c.(802-804)GCT>GTT	p.A268V	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.A268V	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	268	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)																	---	---	---	---
TMEM104	54868	broad.mit.edu	37	17	72832395	72832395	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72832395C>T	uc002jls.3	+	10	1222	c.1060C>T	c.(1060-1062)CGC>TGC	p.R354C	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.R354C	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	354	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)																	---	---	---	---
FDXR	2232	broad.mit.edu	37	17	72860346	72860346	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72860346C>T	uc002jly.2	-	9	1013	c.926G>A	c.(925-927)CGA>CAA	p.R309Q	FDXR_uc010wri.1_Missense_Mutation_p.R257Q|FDXR_uc010wrj.1_Missense_Mutation_p.R307Q|FDXR_uc002jlw.2_Missense_Mutation_p.R66Q|FDXR_uc002jlx.2_Missense_Mutation_p.R315Q|FDXR_uc002jmc.2_Missense_Mutation_p.R281Q|FDXR_uc010wrk.1_Missense_Mutation_p.R340Q|FDXR_uc010wrl.1_Missense_Mutation_p.R352Q|FDXR_uc002jma.2_Missense_Mutation_p.R310Q|FDXR_uc010wrm.1_Missense_Mutation_p.R269Q|FDXR_uc002jlz.2_Missense_Mutation_p.R301Q|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	309					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)																	---	---	---	---
C17orf28	283987	broad.mit.edu	37	17	72959143	72959143	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72959143G>A	uc002jmj.3	-	4	570	c.421C>T	c.(421-423)CTG>TTG	p.L141L	C17orf28_uc010wrs.1_5'UTR|C17orf28_uc002jmk.2_Silent_p.L140L	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	141						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)																	---	---	---	---
SLC16A5	9121	broad.mit.edu	37	17	73096199	73096199	+	Silent	SNP	C	T	T	rs142993518	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73096199C>T	uc002jmr.2	+	5	813	c.441C>T	c.(439-441)GGC>GGT	p.G147G	SLC16A5_uc002jms.1_Silent_p.G147G|SLC16A5_uc002jmt.2_Silent_p.G147G|SLC16A5_uc002jmu.2_Silent_p.G147G|SLC16A5_uc010wrt.1_Silent_p.G187G	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	147	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)													---	---	---	---
RECQL5	9400	broad.mit.edu	37	17	73626707	73626707	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73626707G>A	uc010dgl.2	-	13	1866	c.1710C>T	c.(1708-1710)ACC>ACT	p.T570T	RECQL5_uc010dgk.2_Silent_p.T543T|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	570					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)										Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
RECQL5	9400	broad.mit.edu	37	17	73646745	73646745	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73646745A>G	uc010dgl.2	-						RECQL5_uc010dgk.2_Intron|RECQL5_uc002jpb.1_3'UTR|RECQL5_uc002joz.3_Missense_Mutation_p.V428A|RECQL5_uc002jpa.3_Missense_Mutation_p.V428A	NM_004259	NP_004250			RecQ protein-like 5 isoform 1						DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)										Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73745107	73745107	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73745107C>A	uc002jpg.2	+	27	3484	c.3297C>A	c.(3295-3297)ACC>ACA	p.T1099T	ITGB4_uc002jph.2_Silent_p.T1099T|ITGB4_uc002jpi.3_Silent_p.T1099T|ITGB4_uc002jpj.2_Silent_p.T1099T	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1099	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73746952	73746952	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73746952G>A	uc002jpg.2	+						ITGB4_uc002jph.2_Intron|ITGB4_uc002jpi.3_Intron|ITGB4_uc002jpj.2_Intron	NM_000213	NP_000204			integrin beta 4 isoform 1 precursor						cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73748559	73748559	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73748559G>A	uc002jpg.2	+	32	4196	c.4009G>A	c.(4009-4011)GCC>ACC	p.A1337T	ITGB4_uc002jph.2_Missense_Mutation_p.A1337T|ITGB4_uc002jpi.3_Missense_Mutation_p.A1337T|ITGB4_uc002jpj.2_Missense_Mutation_p.A1337T|GALK1_uc010wsi.1_Intron	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1337	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
TRIM47	91107	broad.mit.edu	37	17	73871509	73871509	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73871509A>G	uc002jpw.2	-	5	1275	c.1248T>C	c.(1246-1248)AGT>AGC	p.S416S	TRIM47_uc002jpv.2_Silent_p.S178S	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	416	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
EXOC7	23265	broad.mit.edu	37	17	74097856	74097856	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74097856C>T	uc002jqs.2	-	3	310	c.215G>A	c.(214-216)CGG>CAG	p.R72Q	EXOC7_uc010dgv.1_Missense_Mutation_p.R19Q|EXOC7_uc002jqq.2_Missense_Mutation_p.R72Q|EXOC7_uc010wsw.1_Missense_Mutation_p.R72Q|EXOC7_uc010wsx.1_Missense_Mutation_p.R72Q|EXOC7_uc002jqr.2_Missense_Mutation_p.R72Q|EXOC7_uc010wsv.1_Missense_Mutation_p.R31Q|EXOC7_uc002jqu.2_Missense_Mutation_p.R72Q|EXOC7_uc002jqv.2_Missense_Mutation_p.R72Q	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	72	Potential.				exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
FOXJ1	2302	broad.mit.edu	37	17	74134076	74134076	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74134076G>A	uc002jqw.2	-	2	714	c.624C>T	c.(622-624)GGC>GGT	p.G208G	FOXJ1_uc002jqx.2_Silent_p.G208G|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	208	Fork-head.				actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74154490	74154490	+	Missense_Mutation	SNP	A	G	G	rs79252974		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74154490A>G	uc002jqz.2	-	13	1466	c.1397T>C	c.(1396-1398)GTT>GCT	p.V466A	RNF157_uc002jra.2_Missense_Mutation_p.V466A	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	466	Ser-rich.						zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
RNF157	114804	broad.mit.edu	37	17	74158016	74158016	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74158016G>A	uc002jqz.2	-	10	929	c.860C>T	c.(859-861)ACC>ATC	p.T287I	RNF157_uc002jra.2_Missense_Mutation_p.T287I	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	287	RING-type.						zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
PRPSAP1	5635	broad.mit.edu	37	17	74344633	74344633	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74344633A>G	uc010wta.1	-	2	646	c.200T>C	c.(199-201)GTT>GCT	p.V67A	PRPSAP1_uc010wtb.1_5'UTR	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	38					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1																		---	---	---	---
UBE2O	63893	broad.mit.edu	37	17	74392545	74392545	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74392545T>G	uc002jrm.3	-	14	2538	c.2473A>C	c.(2473-2475)AAG>CAG	p.K825Q	UBE2O_uc002jrn.3_Missense_Mutation_p.K825Q|UBE2O_uc002jrl.3_Missense_Mutation_p.K429Q	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	825	Potential.						ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5																		---	---	---	---
JMJD6	23210	broad.mit.edu	37	17	74714908	74714908	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74714908T>C	uc002jso.2	-	6	1439	c.1115A>G	c.(1114-1116)CAC>CGC	p.H372R	JMJD6_uc002jsn.1_Missense_Mutation_p.H372R|JMJD6_uc010dgz.2_Missense_Mutation_p.T326A	NM_015167	NP_055982	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6 isoform 2	372					mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			skin(2)|ovary(1)	3																		---	---	---	---
MFSD11	79157	broad.mit.edu	37	17	74737081	74737081	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74737081T>C	uc002jta.2	+	4	1168	c.195T>C	c.(193-195)ATT>ATC	p.I65I	MFSD11_uc002jtb.2_Silent_p.I65I|MFSD11_uc010dha.2_Silent_p.I65I|MFSD11_uc002jtc.2_Silent_p.I65I|MFSD11_uc002jtd.3_Silent_p.I65I|MFSD11_uc010dhb.2_Silent_p.I65I|MFSD11_uc002jte.2_Silent_p.I65I	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	65	Helical; (Potential).					integral to membrane				ovary(1)	1																		---	---	---	---
C17orf86	654434	broad.mit.edu	37	17	75085421	75085421	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:75085421C>T	uc002jtk.3	+						SCARNA16_uc002jtl.2_RNA	NR_027058				Homo sapiens clone FLB3442 PRO0872 mRNA, complete cds.												0																		---	---	---	---
SEC14L1	6397	broad.mit.edu	37	17	75205464	75205464	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:75205464A>G	uc002jto.2	+	14	1784	c.1517A>G	c.(1516-1518)TAC>TGC	p.Y506C	SEC14L1_uc010dhc.2_Missense_Mutation_p.Y506C|SEC14L1_uc010wth.1_Missense_Mutation_p.Y506C|SEC14L1_uc002jtm.2_Missense_Mutation_p.Y506C|SEC14L1_uc010wti.1_Missense_Mutation_p.Y472C|SEC14L1_uc010wtj.1_Missense_Mutation_p.Y66C|SEC14L1_uc002jtr.2_5'UTR	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	506					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2																		---	---	---	---
TNRC6C	57690	broad.mit.edu	37	17	76089187	76089187	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76089187A>G	uc002jud.2	+	16	4744	c.4144A>G	c.(4144-4146)AGC>GGC	p.S1382G	TNRC6C_uc002juf.2_Missense_Mutation_p.S1379G	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	1382	Sufficient for translational repression when tethered to a target mRNA.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	76510904	76510904	+	IGR	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76510904G>T								DNAH17 (42048 upstream) : CYTH1 (159227 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	17	76570976	76570976	+	IGR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76570976G>A								DNAH17 (102120 upstream) : CYTH1 (99155 downstream)																																			---	---	---	---
CBX4	8535	broad.mit.edu	37	17	77809108	77809108	+	Silent	SNP	C	T	T	rs142055924		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:77809108C>T	uc002jxe.2	-	5	496	c.333G>A	c.(331-333)GCG>GCA	p.A111A		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	111	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)													OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CCDC40	55036	broad.mit.edu	37	17	78063612	78063612	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78063612C>T	uc010dht.2	+	17	2788	c.2761C>T	c.(2761-2763)CGT>TGT	p.R921C	CCDC40_uc002jxm.3_Missense_Mutation_p.R704C|CCDC40_uc002jxn.3_Missense_Mutation_p.R317C	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	921	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
EIF4A3	9775	broad.mit.edu	37	17	78111203	78111203	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78111203T>A	uc010wuc.1	-	10	1038	c.965A>T	c.(964-966)GAG>GTG	p.E322V	EIF4A3_uc002jxs.2_Missense_Mutation_p.E322V	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	322	Helicase C-terminal.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78336981	78336981	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78336981C>A	uc002jyh.1	+	15	5877	c.5654C>A	c.(5653-5655)CCG>CAG	p.P1885Q	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.P267Q	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
RNF213	57674	broad.mit.edu	37	17	78345686	78345686	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78345686A>G	uc002jyh.1	+	22	6880	c.6657A>G	c.(6655-6657)GTA>GTG	p.V2219V	uc002jyi.1_Intron|RNF213_uc010dhw.1_Silent_p.V601V	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)															---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78899241	78899241	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78899241C>T	uc002jyt.1	+	24	3685	c.2880C>T	c.(2878-2880)TGC>TGT	p.C960C	RPTOR_uc010wug.1_Silent_p.C802C	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	960					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding	p.C960C(1)		lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
PDE6G	5148	broad.mit.edu	37	17	79620296	79620296	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79620296T>C	uc002kay.3	-	2	184	c.40A>G	c.(40-42)ACC>GCC	p.T14A	PDE6G_uc002kaz.3_Intron	NM_002602	NP_002593	P18545	CNRG_HUMAN	phosphodiesterase 6G	14					platelet activation|visual perception	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity				0	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)															---	---	---	---
P4HB	5034	broad.mit.edu	37	17	79804296	79804296	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79804296C>T	uc002kbn.1	-						P4HB_uc002kbl.1_Intron|P4HB_uc002kbm.1_Intron	NM_000918	NP_000909			prolyl 4-hydroxylase, beta subunit precursor						cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)															---	---	---	---
ANAPC11	51529	broad.mit.edu	37	17	79857828	79857828	+	Missense_Mutation	SNP	T	C	C	rs34978095		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79857828T>C	uc002kbv.1	+	4	357	c.142T>C	c.(142-144)TGG>CGG	p.W48R	ANAPC11_uc002kbw.1_Missense_Mutation_p.W48R|ANAPC11_uc002kbx.1_Missense_Mutation_p.W48R|ANAPC11_uc002kby.1_Missense_Mutation_p.V148A|ANAPC11_uc002kbz.1_Missense_Mutation_p.W48R|ANAPC11_uc002kca.1_Missense_Mutation_p.W48R|ANAPC11_uc002kcb.1_Missense_Mutation_p.W48R|ANAPC11_uc002kcc.1_Missense_Mutation_p.W48R|ANAPC11_uc010dih.1_Missense_Mutation_p.W48R|NPB_uc002kcd.2_5'Flank	NM_016476	NP_057560	Q9NYG5	APC11_HUMAN	APC11 anaphase promoting complex subunit 11	48	RING-type.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)															---	---	---	---
PCYT2	5833	broad.mit.edu	37	17	79864701	79864701	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79864701G>A	uc002kcf.1	-	7	674	c.611C>T	c.(610-612)GCT>GTT	p.A204V	PCYT2_uc010wva.1_Missense_Mutation_p.A172V|PCYT2_uc010wvb.1_Missense_Mutation_p.A172V|PCYT2_uc002kce.1_Missense_Mutation_p.A126V|PCYT2_uc002kcg.1_Missense_Mutation_p.A233V|PCYT2_uc002kch.1_Missense_Mutation_p.A222V|PCYT2_uc002kci.1_Missense_Mutation_p.A163V|PCYT2_uc010dii.1_Missense_Mutation_p.A204V|PCYT2_uc010wvc.1_Missense_Mutation_p.A126V	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	204	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)															---	---	---	---
PCYT2	5833	broad.mit.edu	37	17	79867402	79867402	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79867402C>T	uc002kcf.1	-	2	229	c.166G>A	c.(166-168)GTG>ATG	p.V56M	PCYT2_uc010wva.1_Missense_Mutation_p.V24M|PCYT2_uc010wvb.1_Missense_Mutation_p.V24M|PCYT2_uc002kce.1_Translation_Start_Site|PCYT2_uc002kcg.1_Missense_Mutation_p.V67M|PCYT2_uc002kch.1_Missense_Mutation_p.V56M|PCYT2_uc002kci.1_Translation_Start_Site|PCYT2_uc010dii.1_Missense_Mutation_p.V56M|PCYT2_uc010wvc.1_Translation_Start_Site	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	56	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)															---	---	---	---
SIRT7	51547	broad.mit.edu	37	17	79872167	79872167	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79872167T>C	uc002kcj.1	-						PCYT2_uc002kcf.1_5'Flank|PCYT2_uc002kcg.1_5'Flank|PCYT2_uc002kch.1_5'Flank|PCYT2_uc002kci.1_5'Flank|PCYT2_uc010dii.1_5'Flank|PCYT2_uc010wvc.1_5'Flank|SIRT7_uc002kck.1_Intron|SIRT7_uc002kcl.1_Intron	NM_016538	NP_057622			sirtuin 7						chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)															---	---	---	---
ASPSCR1	79058	broad.mit.edu	37	17	79968697	79968697	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79968697T>C	uc002kcx.2	+	10	1287	c.1190T>C	c.(1189-1191)TTC>TCC	p.F397S	ASPSCR1_uc002kcw.1_Missense_Mutation_p.F397S|ASPSCR1_uc002kcy.2_Missense_Mutation_p.F397S|ASPSCR1_uc002kcz.2_Missense_Mutation_p.F291S|ASPSCR1_uc002kda.2_Missense_Mutation_p.F320S	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	397	UBX.						protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)					T	TFE3	alveolar soft part sarcoma								---	---	---	---
CCDC57	284001	broad.mit.edu	37	17	80159721	80159721	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80159721C>T	uc002kdz.1	-	3	455	c.100G>A	c.(100-102)GCG>ACG	p.A34T	CCDC57_uc002kdx.1_Missense_Mutation_p.A34T	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	34	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)															---	---	---	---
CD7	924	broad.mit.edu	37	17	80274701	80274701	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80274701G>A	uc002kel.1	-	2	348	c.239C>T	c.(238-240)ACG>ATG	p.T80M	CD7_uc010din.2_Missense_Mutation_p.T80M|CD7_uc002kem.2_Silent_p.Y61Y|CD7_uc010wvk.1_Missense_Mutation_p.T80M	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	80	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)															---	---	---	---
C17orf62	79415	broad.mit.edu	37	17	80402337	80402337	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80402337G>A	uc002kez.2	-	5	477	c.429C>T	c.(427-429)GTC>GTT	p.V143V	C17orf62_uc002kex.2_5'UTR|C17orf62_uc002key.2_5'UTR|C17orf62_uc002kfa.2_Silent_p.V143V|C17orf62_uc010dir.2_Silent_p.V143V|C17orf62_uc002kfb.3_Silent_p.V143V|C17orf62_uc002kfc.3_Silent_p.V129V|C17orf62_uc002kfd.3_5'UTR|C17orf62_uc002kfe.3_5'UTR	NM_001100407	NP_001093877	Q9BQA9	CQ062_HUMAN	hypothetical protein LOC79415 isoform a	143						integral to membrane	protein binding				0	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)															---	---	---	---
FN3K	64122	broad.mit.edu	37	17	80699241	80699241	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80699241C>T	uc010wvs.1	+	4	501	c.440C>T	c.(439-441)ACG>ATG	p.T147M	FN3K_uc002kfw.1_Missense_Mutation_p.T102M	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	147					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)															---	---	---	---
B3GNTL1	146712	broad.mit.edu	37	17	80915107	80915107	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80915107C>T	uc002kgg.1	-	10	894	c.880G>A	c.(880-882)GTG>ATG	p.V294M	B3GNTL1_uc002kgf.1_Missense_Mutation_p.V183M|B3GNTL1_uc002kge.1_RNA	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	294							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)															---	---	---	---
CETN1	1068	broad.mit.edu	37	18	580755	580755	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:580755A>G	uc002kko.1	+	1	389	c.347A>G	c.(346-348)GAT>GGT	p.D116G		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	116	EF-hand 3.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
CLUL1	27098	broad.mit.edu	37	18	633332	633332	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:633332A>G	uc002kkp.2	+	6	1036	c.891A>G	c.(889-891)TTA>TTG	p.L297L	CLUL1_uc010wys.1_Silent_p.L349L|CLUL1_uc002kkq.2_Silent_p.L297L	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	297					cell death	extracellular region				ovary(2)	2																		---	---	---	---
YES1	7525	broad.mit.edu	37	18	745763	745763	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:745763A>T	uc002kky.2	-	6	890	c.669T>A	c.(667-669)TAT>TAA	p.Y223*	YES1_uc002kkz.2_Nonsense_Mutation_p.Y223*	NM_005433	NP_005424	P07947	YES_HUMAN	viral oncogene yes-1 homolog 1	223	SH2.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|ovary(1)	3					Dasatinib(DB01254)													---	---	---	---
METTL4	64863	broad.mit.edu	37	18	2544269	2544269	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2544269C>T	uc002klh.3	-	8	1978	c.1198G>A	c.(1198-1200)GTG>ATG	p.V400M	METTL4_uc010dkj.2_Intron	NM_022840	NP_073751	Q8N3J2	METL4_HUMAN	methyltransferase like 4	400					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		methyltransferase activity|nucleic acid binding			kidney(1)|skin(1)	2																		---	---	---	---
NDC80	10403	broad.mit.edu	37	18	2575051	2575051	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2575051G>A	uc002kli.2	+	3	347	c.165G>A	c.(163-165)TCG>TCA	p.S55S		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	55	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1																		---	---	---	---
LPIN2	9663	broad.mit.edu	37	18	2921586	2921586	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2921586T>C	uc002klo.2	-	18	2626	c.2387A>G	c.(2386-2388)AAT>AGT	p.N796S		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	796	C-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)														---	---	---	---
MYOM1	8736	broad.mit.edu	37	18	3100193	3100193	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3100193G>A	uc002klp.2	-	25	4025	c.3691C>T	c.(3691-3693)CGT>TGT	p.R1231C	MYOM1_uc002klq.2_Missense_Mutation_p.R1135C	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	1231						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
ARHGAP28	79822	broad.mit.edu	37	18	6909002	6909002	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:6909002T>C	uc010wzi.1	+	16	1781	c.1543T>C	c.(1543-1545)TAT>CAT	p.Y515H	ARHGAP28_uc002kne.2_Missense_Mutation_p.Y533H			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	515					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)																---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7014024	7014024	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7014024C>T	uc002knm.2	-	23	3247	c.3153G>A	c.(3151-3153)TCG>TCA	p.S1051S	LAMA1_uc010wzj.1_Silent_p.S527S	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1051	Laminin EGF-like 12.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7044712	7044712	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7044712T>C	uc002knm.2	-						LAMA1_uc010wzj.1_Intron	NM_005559	NP_005550			laminin, alpha 1 precursor						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
KIAA0802	23255	broad.mit.edu	37	18	8784591	8784591	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8784591G>A	uc002knr.2	+	6	1623	c.1481G>A	c.(1480-1482)GGC>GAC	p.G494D	KIAA0802_uc002knq.2_Missense_Mutation_p.G494D|KIAA0802_uc010dkw.1_Missense_Mutation_p.G332D	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	845											0																		---	---	---	---
SEH1L	81929	broad.mit.edu	37	18	12982630	12982630	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12982630T>C	uc002krr.2	+	7	1013	c.875T>C	c.(874-876)GTG>GCG	p.V292A	SEH1L_uc002krq.2_Missense_Mutation_p.V292A	NM_031216	NP_112493	Q96EE3	SEH1_HUMAN	sec13-like protein isoform 2	292	WD 6.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex					0																		---	---	---	---
CEP192	55125	broad.mit.edu	37	18	13117599	13117599	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13117599C>T	uc010xac.1	+	44	7512	c.7432C>T	c.(7432-7434)CCC>TCC	p.P2478S	CEP192_uc010xad.1_Missense_Mutation_p.P2003S|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.P901S|CEP192_uc002krw.2_Missense_Mutation_p.P628S|CEP192_uc002krx.2_Missense_Mutation_p.P482S|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2478										ovary(4)|pancreas(1)	5																		---	---	---	---
C18orf19	125228	broad.mit.edu	37	18	13682058	13682058	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13682058G>A	uc010dlh.2	-	3	451	c.19C>T	c.(19-21)CGG>TGG	p.R7W	C18orf19_uc010dlg.2_Missense_Mutation_p.R7W|C18orf19_uc010dli.2_Missense_Mutation_p.R7W|C18orf19_uc002ksj.3_Missense_Mutation_p.R7W|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	7						integral to membrane				breast(2)	2																		---	---	---	---
RNMT	8731	broad.mit.edu	37	18	13731863	13731863	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13731863A>G	uc002ksk.1	+	2	414	c.347A>G	c.(346-348)AAA>AGA	p.K116R	RNMT_uc002ksl.1_Missense_Mutation_p.K116R|RNMT_uc002ksm.1_Missense_Mutation_p.K116R|RNMT_uc010dlk.2_Missense_Mutation_p.K116R|RNMT_uc010xae.1_Intron	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	116					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0																		---	---	---	---
MC5R	4161	broad.mit.edu	37	18	13826335	13826335	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:13826335A>G	uc010xaf.1	+	1	571	c.571A>G	c.(571-573)ATC>GTC	p.I191V		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	191	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	14184003	14184003	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14184003T>C	uc010xag.1	+	3	692	c.394T>C	c.(394-396)TAC>CAC	p.Y132H	uc002ksv.1_Silent_p.S10S					RecName: Full=Putative ankyrin repeat domain-containing protein 20A5;																														---	---	---	---
ABHD3	171586	broad.mit.edu	37	18	19283615	19283615	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19283615A>G	uc002ktl.2	-	2	396	c.256T>C	c.(256-258)TGC>CGC	p.C86R	ABHD3_uc002ktm.2_Missense_Mutation_p.C86R|ABHD3_uc010xao.1_RNA|MIB1_uc002ktp.2_5'Flank|ABHD3_uc002kto.2_Missense_Mutation_p.C86R	NM_138340	NP_612213	Q8WU67	ABHD3_HUMAN	alpha/beta hydrolase domain containing protein	86						integral to membrane	carboxylesterase activity			central_nervous_system(1)	1																		---	---	---	---
MIB1	57534	broad.mit.edu	37	18	19418353	19418353	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19418353A>G	uc002ktq.2	+	13	1857	c.1857A>G	c.(1855-1857)TTA>TTG	p.L619L	MIB1_uc002ktp.2_Silent_p.L258L	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	619	ANK 6.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)															---	---	---	---
GATA6	2627	broad.mit.edu	37	18	19762729	19762729	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19762729A>G	uc002ktt.1	+	5	1705	c.1440A>G	c.(1438-1440)CCA>CCG	p.P480P	GATA6_uc002ktu.1_Silent_p.P480P	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	480					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)															---	---	---	---
CTAGE1	64693	broad.mit.edu	37	18	19996570	19996570	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:19996570C>T	uc002ktv.1	-	1	1309	c.1205G>A	c.(1204-1206)CGA>CAA	p.R402Q		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	402	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)																	---	---	---	---
C18orf45	85019	broad.mit.edu	37	18	20889670	20889670	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20889670C>T	uc002kuf.2	-	14	913	c.804G>A	c.(802-804)GCG>GCA	p.A268A	C18orf45_uc010xaq.1_RNA|C18orf45_uc010xar.1_RNA|C18orf45_uc002kug.2_RNA|C18orf45_uc002kuh.2_RNA|C18orf45_uc002kue.2_RNA	NM_032933	NP_116322	Q24JQ0	CR045_HUMAN	hypothetical protein LOC85019	268	Helical; (Potential).					integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)																	---	---	---	---
C18orf45	85019	broad.mit.edu	37	18	20936549	20936549	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:20936549T>C	uc002kuf.2	-						C18orf45_uc010xaq.1_Intron|C18orf45_uc010xar.1_Intron|C18orf45_uc002kug.2_Intron|C18orf45_uc002kuh.2_Intron	NM_032933	NP_116322			hypothetical protein LOC85019							integral to membrane					0	all_cancers(21;0.000238)|all_epithelial(16;5.29e-06)|Lung NSC(20;0.00925)|Colorectal(14;0.0202)|all_lung(20;0.0255)|Ovarian(20;0.127)																	---	---	---	---
RIOK3	8780	broad.mit.edu	37	18	21044566	21044566	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21044566A>G	uc002kui.3	+	5	1134	c.517A>G	c.(517-519)AGA>GGA	p.R173G	RIOK3_uc010dls.2_Missense_Mutation_p.R173G|RIOK3_uc010xas.1_Missense_Mutation_p.R157G|RIOK3_uc010xat.1_5'Flank	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	173					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
C18orf8	29919	broad.mit.edu	37	18	21109267	21109267	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21109267G>A	uc010xax.1	+						C18orf8_uc002kul.2_Intron|C18orf8_uc010xay.1_Intron|NPC1_uc010dlu.1_RNA	NM_013326	NP_037458			colon cancer-associated protein Mic1											ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21123433	21123433	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21123433A>G	uc002kum.3	-	14	2505	c.2231T>C	c.(2230-2232)GTA>GCA	p.V744A	NPC1_uc010xaz.1_Missense_Mutation_p.V477A|NPC1_uc010xba.1_Missense_Mutation_p.V589A	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	744	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21128008	21128008	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21128008A>G	uc002kum.3	-	11	1993	c.1719T>C	c.(1717-1719)GAT>GAC	p.D573D	NPC1_uc010xaz.1_Intron|NPC1_uc010xba.1_Silent_p.D418D	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	573					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21136572	21136572	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21136572C>T	uc002kum.3	-	8	1235	c.961G>A	c.(961-963)GCG>ACG	p.A321T	NPC1_uc010xaz.1_Missense_Mutation_p.A122T|NPC1_uc010xba.1_Missense_Mutation_p.A166T	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	321					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21140278	21140278	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21140278G>A	uc002kum.3	-	6	1072	c.798C>T	c.(796-798)GAC>GAT	p.D266D	NPC1_uc010xaz.1_Silent_p.D50D|NPC1_uc010xba.1_Silent_p.D111D	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	266					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
NPC1	4864	broad.mit.edu	37	18	21141338	21141338	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21141338G>A	uc002kum.3	-	5	891	c.617C>T	c.(616-618)ACT>ATT	p.T206I	NPC1_uc010xaz.1_5'Flank|NPC1_uc010xba.1_Missense_Mutation_p.T51I	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	206					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21479039	21479039	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21479039G>A	uc002kuq.2	+						LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Intron|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762			laminin alpha 3 subunit isoform 1						cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA3	3909	broad.mit.edu	37	18	21494727	21494727	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21494727G>A	uc002kuq.2	+	58	7633	c.7547G>A	c.(7546-7548)GGA>GAA	p.G2516E	LAMA3_uc002kur.2_Missense_Mutation_p.G2460E|LAMA3_uc002kus.3_Missense_Mutation_p.G907E|LAMA3_uc002kut.3_Missense_Mutation_p.G851E	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2516	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
ZNF521	25925	broad.mit.edu	37	18	22804898	22804898	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22804898A>G	uc002kvk.2	-	4	3231	c.2984T>C	c.(2983-2985)ATG>ACG	p.M995T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.M995T|ZNF521_uc002kvl.2_Missense_Mutation_p.M775T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	995					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)							T	PAX5	ALL								---	---	---	---
SS18	6760	broad.mit.edu	37	18	23614972	23614972	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23614972A>G	uc002kvm.2	-	9	1171	c.1093T>C	c.(1093-1095)TAC>CAC	p.Y365H	SS18_uc002kvn.2_Missense_Mutation_p.Y334H|SS18_uc010xbf.1_Missense_Mutation_p.Y283H|SS18_uc010xbg.1_Missense_Mutation_p.Y282H|SS18_uc010xbh.1_Missense_Mutation_p.Y282H|SS18_uc010xbi.1_Missense_Mutation_p.Y342H|SS18_uc010dlz.1_Missense_Mutation_p.Y313H	NM_001007559	NP_001007560	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	365	2.|Gln-rich.|2 X 13 AA imperfect tandem repeats.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX1(1169)|SS18/SSX2(702)|SS18/SSX4(12)	soft_tissue(1883)|ovary(1)	1884	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)							T	SSX1| SSX2	synovial sarcoma								---	---	---	---
PSMA8	143471	broad.mit.edu	37	18	23731795	23731795	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23731795T>C	uc002kvq.2	+						PSMA8_uc002kvo.2_Intron|PSMA8_uc002kvp.2_Intron|PSMA8_uc002kvr.2_Intron	NM_144662	NP_653263			proteasome alpha 8 subunit isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)															---	---	---	---
PSMA8	143471	broad.mit.edu	37	18	23731934	23731934	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23731934A>G	uc002kvq.2	+	3	474	c.360A>G	c.(358-360)GCA>GCG	p.A120A	PSMA8_uc002kvo.2_Silent_p.A76A|PSMA8_uc002kvp.2_Silent_p.A114A|PSMA8_uc002kvr.2_Silent_p.A88A	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	120					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)															---	---	---	---
PSMA8	143471	broad.mit.edu	37	18	23758901	23758901	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23758901A>G	uc002kvq.2	+	5	717	c.603A>G	c.(601-603)AAA>AAG	p.K201K	PSMA8_uc002kvo.2_Silent_p.K157K|PSMA8_uc002kvp.2_Silent_p.K195K|PSMA8_uc002kvr.2_Silent_p.K169K	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	201					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)															---	---	---	---
CHST9	83539	broad.mit.edu	37	18	24722666	24722666	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:24722666T>C	uc002kwd.2	-	1	306	c.108A>G	c.(106-108)GAA>GAG	p.E36E	C18orf16_uc010xbm.1_Intron|CHST9_uc002kwe.2_Silent_p.E36E	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	36	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)																	---	---	---	---
DSC3	1825	broad.mit.edu	37	18	28602467	28602467	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28602467A>G	uc002kwj.3	-	7	932	c.777T>C	c.(775-777)GGT>GGC	p.G259G	DSC3_uc002kwi.3_Silent_p.G259G	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	259	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)															---	---	---	---
RNF125	54941	broad.mit.edu	37	18	29617236	29617236	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29617236T>C	uc002kxf.1	+							NM_017831	NP_060301			ring finger protein 125						negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0																		---	---	---	---
FAM59A	64762	broad.mit.edu	37	18	29867755	29867755	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29867755G>A	uc002kxl.2	-	4	861	c.805C>T	c.(805-807)CAC>TAC	p.H269Y	FAM59A_uc002kxk.1_Missense_Mutation_p.H269Y	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	269	CABIT.									ovary(1)|skin(1)	2																		---	---	---	---
C18orf34	374864	broad.mit.edu	37	18	30846912	30846912	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30846912A>T	uc002kxn.2	-	13	1519	c.1377T>A	c.(1375-1377)GAT>GAA	p.D459E	C18orf34_uc010dme.1_5'UTR|C18orf34_uc010xbr.1_Missense_Mutation_p.D459E|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.D459E|C18orf34_uc002kxp.2_Missense_Mutation_p.D459E	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	459	Potential.									ovary(1)	1																		---	---	---	---
C18orf34	374864	broad.mit.edu	37	18	30950126	30950126	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30950126T>C	uc002kxn.2	-	5	378	c.236A>G	c.(235-237)TAC>TGC	p.Y79C	C18orf34_uc010xbr.1_Missense_Mutation_p.Y79C|C18orf34_uc010dmf.1_Missense_Mutation_p.Y79C|C18orf34_uc002kxo.2_Missense_Mutation_p.Y79C|C18orf34_uc002kxp.2_Missense_Mutation_p.Y79C	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	79										ovary(1)	1																		---	---	---	---
ASXL3	80816	broad.mit.edu	37	18	31251755	31251755	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31251755A>G	uc010dmg.1	+	7	695	c.640A>G	c.(640-642)ATG>GTG	p.M214V	ASXL3_uc002kxq.2_5'UTR	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
ASXL3	80816	broad.mit.edu	37	18	31324921	31324921	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31324921A>C	uc010dmg.1	+	12	5164	c.5109A>C	c.(5107-5109)CAA>CAC	p.Q1703H	ASXL3_uc002kxq.2_Missense_Mutation_p.Q1410H	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1703					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
ASXL3	80816	broad.mit.edu	37	18	31325827	31325827	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:31325827T>C	uc010dmg.1	+	12	6070	c.6015T>C	c.(6013-6015)ACT>ACC	p.T2005T	ASXL3_uc002kxq.2_Silent_p.T1712T	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2005					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
ELP2	55250	broad.mit.edu	37	18	33721158	33721158	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33721158T>C	uc002kzk.1	+	6	592	c.582T>C	c.(580-582)AAT>AAC	p.N194N	ELP2_uc010xcg.1_Silent_p.N259N|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.N168N|ELP2_uc010xch.1_Silent_p.N233N|ELP2_uc002kzn.1_Silent_p.N168N|ELP2_uc002kzo.1_Intron	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	194	WD 4.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
ELP2	55250	broad.mit.edu	37	18	33750064	33750064	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33750064T>C	uc002kzk.1	+	20	2125	c.2115T>C	c.(2113-2115)TGT>TGC	p.C705C	ELP2_uc010xcg.1_Silent_p.C770C|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Silent_p.C679C|ELP2_uc010xch.1_Silent_p.C700C|ELP2_uc002kzn.1_Silent_p.C635C|ELP2_uc002kzo.1_Silent_p.C635C	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	705	WD 12.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
PIK3C3	5289	broad.mit.edu	37	18	39600672	39600672	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:39600672A>G	uc002lap.2	+						PIK3C3_uc010xcl.1_Intron	NM_002647	NP_002638			catalytic phosphatidylinositol 3-kinase 3						cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10															TSP Lung(28;0.18)			---	---	---	---
SYT4	6860	broad.mit.edu	37	18	40853990	40853990	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:40853990G>A	uc002law.2	-	2	773	c.404C>T	c.(403-405)TCC>TTC	p.S135F	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.S117F|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	135	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5																		---	---	---	---
SLC14A2	8170	broad.mit.edu	37	18	43252904	43252904	+	Missense_Mutation	SNP	G	A	A	rs142459777	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43252904G>A	uc010dnj.2	+	18	2590	c.2269G>A	c.(2269-2271)GGC>AGC	p.G757S	SLC14A2_uc002lbe.2_Missense_Mutation_p.G757S	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	757						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43438628	43438628	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43438628C>T	uc002lbm.2	-	41	7229	c.7129G>A	c.(7129-7131)GTC>ATC	p.V2377I	KIAA1632_uc010xcq.1_Missense_Mutation_p.V931I|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.V1252I	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2377					autophagy						0																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43464646	43464646	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43464646T>C	uc002lbm.2	-	30	5340	c.5240A>G	c.(5239-5241)TAT>TGT	p.Y1747C	KIAA1632_uc010xcq.1_Missense_Mutation_p.Y301C|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.Y622C	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1747					autophagy						0																		---	---	---	---
HAUS1	115106	broad.mit.edu	37	18	43703311	43703311	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43703311C>A	uc002lbu.2	+	6	727	c.647C>A	c.(646-648)TCC>TAC	p.S216Y	HAUS1_uc002lbv.2_Missense_Mutation_p.S140Y	NM_138443	NP_612452	Q96CS2	HAUS1_HUMAN	coiled-coil domain containing 5	216					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				ovary(1)	1																		---	---	---	---
TCEB3B	51224	broad.mit.edu	37	18	44560527	44560527	+	Missense_Mutation	SNP	A	G	G	rs111815744		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44560527A>G	uc002lcr.1	-	1	1462	c.1109T>C	c.(1108-1110)GTA>GCA	p.V370A	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	370					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
HDHD2	84064	broad.mit.edu	37	18	44639388	44639388	+	Silent	SNP	C	T	T	rs150843690		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44639388C>T	uc002lcs.2	-	6	769	c.636G>A	c.(634-636)GGG>GGA	p.G212G	HDHD2_uc002lct.2_Silent_p.G122G	NM_032124	NP_115500	Q9H0R4	HDHD2_HUMAN	haloacid dehalogenase-like hydrolase domain	212							hydrolase activity				0																		---	---	---	---
HDHD2	84064	broad.mit.edu	37	18	44662707	44662707	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44662707T>C	uc002lcs.2	-						HDHD2_uc002lct.2_5'UTR	NM_032124	NP_115500			haloacid dehalogenase-like hydrolase domain								hydrolase activity				0																		---	---	---	---
C18orf32	497661	broad.mit.edu	37	18	47017228	47017228	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47017228C>T	uc002ldm.1	-	3	164	c.151G>A	c.(151-153)GTC>ATC	p.V51I	RPL17_uc002ldn.2_Missense_Mutation_p.V13I|RPL17_uc002ldo.2_Missense_Mutation_p.V51I|RPL17_uc002ldp.2_Missense_Mutation_p.V51I|RPL17_uc002ldq.2_Missense_Mutation_p.V51I|RPL17_uc010xdg.1_Missense_Mutation_p.V13I|SNORD58C_uc002ldr.2_5'Flank	NM_001035006	NP_001030178	Q8TCD1	CR032_HUMAN	ribosomal protein L17	Error:Variant_position_missing_in_Q8TCD1_after_alignment					positive regulation of I-kappaB kinase/NF-kappaB cascade		signal transducer activity				0																		---	---	---	---
CXXC1	30827	broad.mit.edu	37	18	47808995	47808995	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47808995T>C	uc002leq.3	-	15	2672	c.1939A>G	c.(1939-1941)ACT>GCT	p.T647A	MBD1_uc002leg.2_5'Flank|MBD1_uc010dow.1_5'Flank|MBD1_uc010xdi.1_5'Flank|MBD1_uc002leh.3_5'Flank|MBD1_uc002len.2_5'Flank|MBD1_uc002lei.3_5'Flank|MBD1_uc002lej.3_5'Flank|MBD1_uc002lek.3_5'Flank|MBD1_uc002lel.3_5'Flank|MBD1_uc002lem.3_5'Flank|MBD1_uc010xdj.1_5'Flank|MBD1_uc010xdk.1_5'Flank|MBD1_uc010dox.1_5'Flank|MBD1_uc002leo.2_5'Flank|CXXC1_uc002lep.3_Missense_Mutation_p.T504A|CXXC1_uc002ler.3_Missense_Mutation_p.T651A|CXXC1_uc010doy.2_3'UTR	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	647					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ME2	4200	broad.mit.edu	37	18	48446896	48446896	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:48446896T>C	uc002ley.2	+	8	1061	c.805T>C	c.(805-807)TAC>CAC	p.Y269H	ME2_uc010dpd.2_Missense_Mutation_p.Y269H	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	269					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)													---	---	---	---
DCC	1630	broad.mit.edu	37	18	50961583	50961583	+	Intron	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50961583A>C	uc002lfe.1	+						DCC_uc010dpf.1_Intron	NM_005215	NP_005206			netrin receptor DCC precursor						apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
CCDC68	80323	broad.mit.edu	37	18	52604149	52604149	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52604149T>C	uc002lfs.2	-	6	558	c.386A>G	c.(385-387)AAC>AGC	p.N129S	CCDC68_uc002lft.2_Missense_Mutation_p.N129S	NM_001143829	NP_001137301	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	129	Potential.									skin(1)	1				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)														---	---	---	---
TCF4	6925	broad.mit.edu	37	18	53254318	53254318	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:53254318T>C	uc002lfz.2	-	2	642	c.30A>G	c.(28-30)TTA>TTG	p.L10L	TCF4_uc010xdx.1_5'Flank|TCF4_uc010dph.1_Silent_p.L10L|TCF4_uc010xdy.1_Intron|TCF4_uc002lga.2_Silent_p.L112L|TCF4_uc010dpi.2_Silent_p.L10L	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	10	Essential for MYOD1 inhibition (By similarity).				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)														---	---	---	---
TXNL1	9352	broad.mit.edu	37	18	54283492	54283492	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54283492A>G	uc002lgg.2	-	5	795	c.546T>C	c.(544-546)TTT>TTC	p.F182F	TXNL1_uc010xdz.1_RNA|TXNL1_uc002lgh.2_RNA|TXNL1_uc002lgi.2_Silent_p.F182F|TXNL1_uc002lgj.1_Silent_p.F182F	NM_004786	NP_004777	O43396	TXNL1_HUMAN	thioredoxin-like 1	182	PITH.				cell redox homeostasis|electron transport chain|glycerol ether metabolic process|transport	cytoplasm	electron carrier activity|protein disulfide oxidoreductase activity				0				READ - Rectum adenocarcinoma(59;0.193)|Colorectal(16;0.211)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54398627	54398627	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54398627T>C	uc002lgk.1	+	14	1999	c.1788T>C	c.(1786-1788)CGT>CGC	p.R596R	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.R596R	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	596	WD 7.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54483318	54483318	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54483318C>T	uc002lgk.1	+	20	3458	c.3247C>T	c.(3247-3249)CCT>TCT	p.P1083S	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.P1050S	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1083										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54629767	54629767	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54629767A>G	uc002lgk.1	+						WDR7_uc002lgl.1_Intron	NM_015285	NP_056100			rabconnectin-3 beta isoform 1											ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
FECH	2235	broad.mit.edu	37	18	55238724	55238724	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55238724C>T	uc002lgq.3	-	4	480	c.363G>A	c.(361-363)GAG>GAA	p.E121E	FECH_uc002lgp.3_Silent_p.E127E|FECH_uc002lgr.3_5'UTR	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	121					generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)																---	---	---	---
FECH	2235	broad.mit.edu	37	18	55240607	55240607	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55240607A>G	uc002lgq.3	-						FECH_uc002lgp.3_Intron|FECH_uc002lgr.3_Intron	NM_000140	NP_000131			ferrochelatase isoform b precursor						generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)																---	---	---	---
NARS	4677	broad.mit.edu	37	18	55274419	55274419	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55274419A>G	uc002lgs.2	-	9	1176	c.948T>C	c.(946-948)TGT>TGC	p.C316C	NARS_uc002lgt.2_Silent_p.C315C|NARS_uc010xea.1_Silent_p.C67C|NARS_uc010xeb.1_RNA|NARS_uc010xec.1_3'UTR|NARS_uc010xed.1_3'UTR	NM_004539	NP_004530	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	316					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding				0		Colorectal(73;0.227)			L-Asparagine(DB00174)													---	---	---	---
ALPK2	115701	broad.mit.edu	37	18	56246328	56246328	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56246328A>G	uc002lhj.3	-	4	1894	c.1680T>C	c.(1678-1680)GGT>GGC	p.G560G		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	560							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14																OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RNF152	220441	broad.mit.edu	37	18	59483265	59483265	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59483265A>G	uc002lih.1	-	2	844	c.432T>C	c.(430-432)GGT>GGC	p.G144G		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	144					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)																---	---	---	---
PHLPP1	23239	broad.mit.edu	37	18	60506064	60506064	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:60506064T>C	uc002lis.2	+	4	463	c.285T>C	c.(283-285)TCT>TCC	p.S95S		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	607	PH.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0																		---	---	---	---
VPS4B	9525	broad.mit.edu	37	18	61064287	61064287	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61064287A>G	uc002lix.2	-	9	1332	c.1072T>C	c.(1072-1074)TCA>CCA	p.S358P	VPS4B_uc010dpx.2_Missense_Mutation_p.S358P|VPS4B_uc010dpy.2_Missense_Mutation_p.S240P|VPS4B_uc010dpz.1_Missense_Mutation_p.S240P	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	358					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1																		---	---	---	---
SERPINB10	5273	broad.mit.edu	37	18	61582880	61582880	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61582880G>A	uc010xev.1	+	2	226	c.136G>A	c.(136-138)GCC>ACC	p.A46T	SERPINB2_uc002ljp.1_Missense_Mutation_p.A187T|SERPINB2_uc002ljq.1_Missense_Mutation_p.A160T|SERPINB10_uc010xew.1_Missense_Mutation_p.A46T	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	46						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)																---	---	---	---
DSEL	92126	broad.mit.edu	37	18	65181836	65181836	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:65181836T>C	uc002lke.1	-	2	1264	c.40A>G	c.(40-42)ATG>GTG	p.M14V		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	4						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67697273	67697273	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67697273G>T	uc002lkp.2	-	42	5788	c.5720C>A	c.(5719-5721)CCT>CAT	p.P1907H	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.P995H|RTTN_uc010dqp.2_Missense_Mutation_p.P159H	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1907							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67715294	67715294	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67715294T>C	uc002lkp.2	-	40	5522	c.5454A>G	c.(5452-5454)TTA>TTG	p.L1818L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.L906L|RTTN_uc010dqp.2_Silent_p.L70L	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1818							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67781679	67781679	+	Splice_Site	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67781679A>T	uc002lkp.2	-	27	3751	c.3683_splice	c.e27+1	p.R1228_splice	RTTN_uc002lko.2_Splice_Site|RTTN_uc010xfb.1_Splice_Site_p.R316_splice	NM_173630	NP_775901			rotatin								binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
ZNF407	55628	broad.mit.edu	37	18	72347596	72347596	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72347596T>C	uc002llw.2	+	1	4678	c.4621T>C	c.(4621-4623)TAT>CAT	p.Y1541H	ZNF407_uc010xfc.1_Missense_Mutation_p.Y1541H|ZNF407_uc010dqu.1_Missense_Mutation_p.Y1541H|ZNF407_uc002llu.2_Missense_Mutation_p.Y1540H	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1541	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)														---	---	---	---
TSHZ1	10194	broad.mit.edu	37	18	72999834	72999834	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72999834G>T	uc002lly.2	+	2	2900	c.2337G>T	c.(2335-2337)GTG>GTT	p.V779V		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	824						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)														---	---	---	---
ZNF516	9658	broad.mit.edu	37	18	74091364	74091364	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74091364C>T	uc010dqx.1	-	3	2941	c.2706G>A	c.(2704-2706)CAG>CAA	p.Q902Q	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	902					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)														---	---	---	---
ZNF236	7776	broad.mit.edu	37	18	74624288	74624288	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74624288G>T	uc002lmi.2	+	17	3086	c.2888G>T	c.(2887-2889)AGC>ATC	p.S963I	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	963					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)														---	---	---	---
ATP9B	374868	broad.mit.edu	37	18	77133944	77133944	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77133944C>T	uc002lmx.2	+	28	3131	c.3117C>T	c.(3115-3117)TTC>TTT	p.F1039F	ATP9B_uc002lmw.1_Silent_p.F1039F|ATP9B_uc002lna.2_Silent_p.F65F|ATP9B_uc002lnb.1_3'UTR|ATP9B_uc010drb.2_RNA	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	1039	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)														---	---	---	---
CTDP1	9150	broad.mit.edu	37	18	77456018	77456018	+	Missense_Mutation	SNP	C	T	T	rs143464787		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77456018C>T	uc002lnh.1	+	3	587	c.440C>T	c.(439-441)ACG>ATG	p.T147M	CTDP1_uc002lni.1_Missense_Mutation_p.T147M|CTDP1_uc010drd.1_Missense_Mutation_p.T147M	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	147					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)														---	---	---	---
MIER2	54531	broad.mit.edu	37	19	308808	308808	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:308808C>T	uc002lok.1	-	11	1111	c.1102G>A	c.(1102-1104)GGA>AGA	p.G368R		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MIER2	54531	broad.mit.edu	37	19	336173	336173	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:336173C>T	uc002lok.1	-	2	19	c.10G>A	c.(10-12)GCC>ACC	p.A4T		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
THEG	51298	broad.mit.edu	37	19	367122	367122	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:367122G>T	uc002lol.2	-	7	895	c.856C>A	c.(856-858)CCC>ACC	p.P286T	THEG_uc002lom.2_Missense_Mutation_p.P262T	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	286					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
SHC2	25759	broad.mit.edu	37	19	422254	422254	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:422254G>A	uc002loq.3	-	11	1512	c.1512C>T	c.(1510-1512)GAC>GAT	p.D504D	SHC2_uc002lop.3_Silent_p.D245D	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	504	SH2.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
POLRMT	5442	broad.mit.edu	37	19	617784	617784	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:617784A>G	uc002lpf.1	-	18	3544	c.3488T>C	c.(3487-3489)ATG>ACG	p.M1163T		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	1163	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
POLRMT	5442	broad.mit.edu	37	19	621761	621761	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:621761A>G	uc002lpf.1	-	10	1993	c.1937T>C	c.(1936-1938)GTA>GCA	p.V646A		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	646					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PTBP1	5725	broad.mit.edu	37	19	808741	808741	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:808741C>T	uc002lpr.2	+	12	1470	c.1364C>T	c.(1363-1365)ACG>ATG	p.T455M	PTBP1_uc002lpp.2_Missense_Mutation_p.T481M|PTBP1_uc002lpq.2_Missense_Mutation_p.T474M|PTBP1_uc002lps.2_Missense_Mutation_p.T121M|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Missense_Mutation_p.T451M	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	455	RRM 4.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MED16	10025	broad.mit.edu	37	19	881601	881601	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:881601C>T	uc002lqd.1	-	7	1250	c.1099G>A	c.(1099-1101)GAC>AAC	p.D367N	MED16_uc010drw.1_Missense_Mutation_p.D192N|MED16_uc002lqe.2_Missense_Mutation_p.D356N|MED16_uc002lqf.2_Missense_Mutation_p.D356N|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.D356N|MED16_uc010xfx.1_Missense_Mutation_p.D212N|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	367					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MED16	10025	broad.mit.edu	37	19	881679	881679	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:881679T>G	uc002lqd.1	-	7	1172	c.1021A>C	c.(1021-1023)ATC>CTC	p.I341L	MED16_uc010drw.1_Missense_Mutation_p.I166L|MED16_uc002lqe.2_Missense_Mutation_p.I330L|MED16_uc002lqf.2_Missense_Mutation_p.I330L|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.I330L|MED16_uc010xfx.1_Missense_Mutation_p.I186L|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	341					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
WDR18	57418	broad.mit.edu	37	19	990844	990844	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:990844A>G	uc002lqm.1	+						WDR18_uc002lqn.1_Intron|WDR18_uc010drx.1_Intron|WDR18_uc010dry.1_Intron	NM_024100	NP_077005			WD repeat domain 18											skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
C19orf6	91304	broad.mit.edu	37	19	1014380	1014380	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1014380C>T	uc002lqr.1	-	2	464	c.318G>A	c.(316-318)CCG>CCA	p.P106P	C19orf6_uc002lqq.1_5'Flank|C19orf6_uc002lqs.1_Silent_p.P106P	NM_001033026	NP_001028198	Q4ZIN3	MBRL_HUMAN	membralin isoform 1	106						cytoplasm|integral to membrane				pancreas(2)|breast(1)	3		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.0252)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
C19orf26	255057	broad.mit.edu	37	19	1234739	1234739	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1234739T>C	uc002lrm.2	-	6	715	c.440A>G	c.(439-441)TAC>TGC	p.Y147C		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	173						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)											HNSCC(14;0.022)			---	---	---	---
DAZAP1	26528	broad.mit.edu	37	19	1434758	1434758	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1434758T>C	uc002lsn.2	+	12	1260	c.1071T>C	c.(1069-1071)AGT>AGC	p.S357S	DAZAP1_uc002lsm.2_3'UTR|DAZAP1_uc002lso.2_Silent_p.S356S|DAZAP1_uc002lsl.1_Silent_p.S356S	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	357	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MBD3	53615	broad.mit.edu	37	19	1584655	1584655	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1584655C>T	uc002ltl.1	-	3	314	c.292G>A	c.(292-294)GCG>ACG	p.A98T	MBD3_uc002ltj.2_Missense_Mutation_p.A98T|MBD3_uc002ltk.2_Missense_Mutation_p.A66T	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	98					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ATP8B3	148229	broad.mit.edu	37	19	1802528	1802528	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1802528T>C	uc002ltw.2	-	11	1255	c.1021A>G	c.(1021-1023)ATT>GTT	p.I341V	ATP8B3_uc002ltv.2_Missense_Mutation_p.I288V|ATP8B3_uc002ltx.2_RNA|ATP8B3_uc002lty.1_Missense_Mutation_p.I89V|ATP8B3_uc002ltz.1_Missense_Mutation_p.I288V	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	341	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
AP3D1	8943	broad.mit.edu	37	19	2109159	2109159	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2109159G>A	uc002luz.2	-	28	3435	c.3212C>T	c.(3211-3213)TCA>TTA	p.S1071L	AP3D1_uc010dsv.2_Missense_Mutation_p.S161L|AP3D1_uc002luy.2_Missense_Mutation_p.S1030L|AP3D1_uc002lva.2_Missense_Mutation_p.S1133L	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	1071					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
AP3D1	8943	broad.mit.edu	37	19	2132554	2132554	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2132554G>A	uc002luz.2	-	5	601	c.378C>T	c.(376-378)TAC>TAT	p.Y126Y	AP3D1_uc002luy.2_Silent_p.Y126Y|AP3D1_uc002lva.2_Silent_p.Y126Y	NM_003938	NP_003929	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1	126					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TMPRSS9	360200	broad.mit.edu	37	19	2416625	2416625	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2416625T>C	uc010xgx.1	+	11	1733	c.1733T>C	c.(1732-1734)GTA>GCA	p.V578A		NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	578	Extracellular (Potential).|Peptidase S1 2.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZNF57	126295	broad.mit.edu	37	19	2917638	2917638	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2917638A>G	uc002lwr.2	+	4	1167	c.1019A>G	c.(1018-1020)CAC>CGC	p.H340R	ZNF57_uc010xha.1_Missense_Mutation_p.H308R	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	340	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZNF57	126295	broad.mit.edu	37	19	2917975	2917975	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2917975C>T	uc002lwr.2	+	4	1504	c.1356C>T	c.(1354-1356)CAC>CAT	p.H452H	ZNF57_uc010xha.1_Silent_p.H420H	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	452	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
NFIC	4782	broad.mit.edu	37	19	3452546	3452546	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3452546C>T	uc010xhi.1	+	8	1213	c.1151C>T	c.(1150-1152)ACG>ATG	p.T384M	NFIC_uc002lxo.2_Missense_Mutation_p.T375M|NFIC_uc010xhh.1_Missense_Mutation_p.T375M|NFIC_uc002lxp.2_Missense_Mutation_p.T384M|NFIC_uc010xhj.1_Missense_Mutation_p.T384M	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	384					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)														---	---	---	---
C19orf29	58509	broad.mit.edu	37	19	3623876	3623876	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3623876T>C	uc002lyh.2	-	2	505	c.452A>G	c.(451-453)AAG>AGG	p.K151R	C19orf29_uc010dtn.2_5'Flank|C19orf29_uc002lyi.3_Missense_Mutation_p.K151R|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	151	Potential.					catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MATK	4145	broad.mit.edu	37	19	3779034	3779034	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3779034G>A	uc002lyt.2	-	12	1553	c.1153C>T	c.(1153-1155)CGG>TGG	p.R385W	MATK_uc002lyv.2_Missense_Mutation_p.R386W|MATK_uc002lyu.2_Missense_Mutation_p.R344W|MATK_uc010dtq.2_Missense_Mutation_p.R385W	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	385	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
EBI3	10148	broad.mit.edu	37	19	4231313	4231313	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4231313A>G	uc002lzu.2	+	2	201	c.193A>G	c.(193-195)ACG>GCG	p.T65A		NM_005755	NP_005746	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3 precursor	65	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
CHAF1A	10036	broad.mit.edu	37	19	4409350	4409350	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4409350A>C	uc002mal.2	+	3	654	c.554A>C	c.(553-555)GAG>GCG	p.E185A		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	185	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)									Chromatin_Structure					---	---	---	---
DPP9	91039	broad.mit.edu	37	19	4684695	4684695	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4684695C>A	uc002mba.2	-	18	2416	c.2158G>T	c.(2158-2160)GGG>TGG	p.G720W		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	691					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)														---	---	---	---
FEM1A	55527	broad.mit.edu	37	19	4792619	4792619	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4792619T>G	uc002mbf.2	+	1	892	c.753T>G	c.(751-753)CCT>CCG	p.P251P	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	251					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)														---	---	---	---
PLIN3	10226	broad.mit.edu	37	19	4852237	4852237	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4852237G>A	uc002mbj.2	-	5	602	c.425C>T	c.(424-426)ACG>ATG	p.T142M	PLIN3_uc002mbk.2_Missense_Mutation_p.T130M|PLIN3_uc002mbl.3_Missense_Mutation_p.T142M	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	142					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)											OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
UHRF1	29128	broad.mit.edu	37	19	4930731	4930731	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4930731A>G	uc002mbo.2	+	4	580	c.412A>G	c.(412-414)AAT>GAT	p.N138D	UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.N151D	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	138					cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)														---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5110675	5110675	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5110675T>C	uc002mbq.3	+	10	1187	c.961T>C	c.(961-963)TTC>CTC	p.F321L	KDM4B_uc010xil.1_Missense_Mutation_p.F321L|KDM4B_uc010xim.1_Missense_Mutation_p.F321L|KDM4B_uc002mbr.3_Missense_Mutation_p.F79L	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	321					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
KDM4B	23030	broad.mit.edu	37	19	5110733	5110733	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5110733C>T	uc002mbq.3	+	10	1245	c.1019C>T	c.(1018-1020)ACG>ATG	p.T340M	KDM4B_uc010xil.1_Missense_Mutation_p.T340M|KDM4B_uc010xim.1_Missense_Mutation_p.T340M|KDM4B_uc002mbr.3_Missense_Mutation_p.T98M	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	340					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1																		---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5208286	5208286	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5208286C>T	uc002mbv.2	-	36	5838	c.5604G>A	c.(5602-5604)GAG>GAA	p.E1868E	PTPRS_uc002mbu.1_Silent_p.E1437E|PTPRS_uc010xin.1_Silent_p.E1410E|PTPRS_uc002mbw.2_Silent_p.E1830E|PTPRS_uc002mbx.2_Silent_p.E1425E|PTPRS_uc002mby.2_Silent_p.E1421E	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1868	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
ACSBG2	81616	broad.mit.edu	37	19	6187367	6187367	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6187367C>A	uc002mef.1	+	12	1841	c.1614C>A	c.(1612-1614)CCC>CCA	p.P538P	ACSBG2_uc002mee.1_Silent_p.P351P|ACSBG2_uc002meg.1_Silent_p.P538P|ACSBG2_uc002meh.1_Silent_p.P538P|ACSBG2_uc002mei.1_Silent_p.P488P|ACSBG2_uc010xiz.1_Silent_p.P538P	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	538					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1																		---	---	---	---
MLLT1	4298	broad.mit.edu	37	19	6230666	6230666	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6230666G>A	uc002mek.2	-	4	499	c.335C>T	c.(334-336)CCG>CTG	p.P112L		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	112	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1								T	MLL	AL								---	---	---	---
MLLT1	4298	broad.mit.edu	37	19	6230719	6230719	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6230719C>T	uc002mek.2	-	4	446	c.282G>A	c.(280-282)GAG>GAA	p.E94E		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	94	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1								T	MLL	AL								---	---	---	---
ACER1	125981	broad.mit.edu	37	19	6309743	6309743	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6309743C>T	uc002mel.2	-	4	531	c.453G>A	c.(451-453)CTG>CTA	p.L151L		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	151	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0																		---	---	---	---
SLC25A23	79085	broad.mit.edu	37	19	6456459	6456459	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6456459T>A	uc002mex.1	-	4	597	c.455A>T	c.(454-456)GAC>GTC	p.D152V	SLC25A23_uc002mev.2_RNA|SLC25A23_uc010xjd.1_5'Flank	NM_024103	NP_077008	Q9BV35	SCMC3_HUMAN	solute carrier family 25, member 23	152	Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
CRB3	92359	broad.mit.edu	37	19	6467020	6467020	+	3'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6467020G>A	uc002mey.2	+	4					CRB3_uc002mez.2_Missense_Mutation_p.C120Y|CRB3_uc002mfa.2_3'UTR	NM_139161	NP_631900			crumbs 3 isoform a precursor						protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0																		---	---	---	---
C3	718	broad.mit.edu	37	19	6710732	6710732	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6710732T>C	uc002mfm.2	-	13	1666	c.1604A>G	c.(1603-1605)TAC>TGC	p.Y535C		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	535					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)														---	---	---	---
TRIP10	9322	broad.mit.edu	37	19	6743530	6743530	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6743530G>A	uc002mfs.2	+	6	500	c.434G>A	c.(433-435)TGC>TAC	p.C145Y	TRIP10_uc010dux.1_Missense_Mutation_p.C145Y|TRIP10_uc002mfr.2_Missense_Mutation_p.C145Y|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_5'UTR	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	145	Potential.|Induction of membrane tubulation.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1																		---	---	---	---
ZNF557	79230	broad.mit.edu	37	19	7083669	7083669	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7083669C>A	uc002mgb.2	+	8	1671	c.1186C>A	c.(1186-1188)CCC>ACC	p.P396T	ZNF557_uc002mga.2_Missense_Mutation_p.P403T|ZNF557_uc002mgc.2_Missense_Mutation_p.P403T	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)														---	---	---	---
INSR	3643	broad.mit.edu	37	19	7150506	7150506	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7150506A>G	uc002mgd.1	-	11	2376	c.2267_splice	c.e11+1	p.R756_splice	INSR_uc002mge.1_Intron	NM_000208	NP_000199			insulin receptor isoform Long precursor						activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
INSR	3643	broad.mit.edu	37	19	7267352	7267352	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7267352G>A	uc002mgd.1	-						INSR_uc002mge.1_Intron|INSR_uc002mgf.2_Intron	NM_000208	NP_000199			insulin receptor isoform Long precursor						activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
ZNF358	140467	broad.mit.edu	37	19	7585023	7585023	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7585023G>A	uc002mgn.2	+	2	1065	c.895G>A	c.(895-897)GCC>ACC	p.A299T	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	299	C2H2-type 6.				embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
MCOLN1	57192	broad.mit.edu	37	19	7591504	7591504	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7591504C>T	uc002mgo.2	+						MCOLN1_uc002mgp.2_Intron	NM_020533	NP_065394			mucolipin 1						calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1																		---	---	---	---
PNPLA6	10908	broad.mit.edu	37	19	7615447	7615447	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7615447G>A	uc010xjq.1	+	18	2213	c.2018G>A	c.(2017-2019)CGG>CAG	p.R673Q	PNPLA6_uc002mgq.1_Missense_Mutation_p.R625Q|PNPLA6_uc010xjp.1_Missense_Mutation_p.R599Q|PNPLA6_uc002mgr.1_Missense_Mutation_p.R625Q|PNPLA6_uc002mgs.2_Missense_Mutation_p.R664Q	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	664	Cytoplasmic (Potential).|cNMP 3.				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3																		---	---	---	---
PNPLA6	10908	broad.mit.edu	37	19	7622065	7622065	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7622065C>T	uc010xjq.1	+	29	3517	c.3322C>T	c.(3322-3324)CGG>TGG	p.R1108W	PNPLA6_uc002mgq.1_Missense_Mutation_p.R1060W|PNPLA6_uc010xjp.1_Missense_Mutation_p.R1033W|PNPLA6_uc002mgr.1_Missense_Mutation_p.R1060W|PNPLA6_uc002mgs.2_Missense_Mutation_p.R1098W|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1099	Patatin.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3																		---	---	---	---
KIAA1543	57662	broad.mit.edu	37	19	7675756	7675756	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7675756A>G	uc002mgv.3	+						KIAA1543_uc002mgu.3_Intron	NM_020902	NP_065953			NEZHA isoform 2						epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1																		---	---	---	---
C19orf59	199675	broad.mit.edu	37	19	7743133	7743133	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7743133T>C	uc002mhh.1	+						TRAPPC5_uc002mhi.1_5'Flank|TRAPPC5_uc002mhj.1_5'Flank|TRAPPC5_uc002mhk.1_5'Flank	NM_174918	NP_777578			mast cell-expressed membrane protein 1							integral to membrane				skin(1)	1																OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CLEC4G	339390	broad.mit.edu	37	19	7794978	7794978	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7794978G>A	uc002mhp.3	-	7	623	c.554C>T	c.(553-555)ACG>ATG	p.T185M		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	185	Extracellular (Potential).|C-type lectin.					integral to membrane	protein binding|sugar binding				0																		---	---	---	---
CLEC4M	10332	broad.mit.edu	37	19	7831545	7831545	+	Missense_Mutation	SNP	G	A	A	rs140767813		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7831545G>A	uc002mih.2	+	6	837	c.719G>A	c.(718-720)CGC>CAC	p.R240H	CLEC4M_uc010xjv.1_3'UTR|CLEC4M_uc002mhy.2_3'UTR|CLEC4M_uc010xjw.1_Missense_Mutation_p.R196H|CLEC4M_uc010dvt.2_Missense_Mutation_p.R217H|CLEC4M_uc010dvs.2_Missense_Mutation_p.R239H|CLEC4M_uc010xjx.1_Missense_Mutation_p.R212H|CLEC4M_uc002mhz.2_Missense_Mutation_p.R171H|CLEC4M_uc002mic.2_Missense_Mutation_p.R235H|CLEC4M_uc002mia.2_Missense_Mutation_p.R127H	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	263	Extracellular (Probable).|7.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1																		---	---	---	---
ELAVL1	1994	broad.mit.edu	37	19	8056606	8056606	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8056606T>C	uc002mjb.2	-	2	261	c.94A>G	c.(94-96)ACC>GCC	p.T32A		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	32	RRM 1.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0																		---	---	---	---
FBN3	84467	broad.mit.edu	37	19	8138042	8138042	+	Silent	SNP	G	A	A	rs116210236	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8138042G>A	uc002mjf.2	-	61	7863	c.7842C>T	c.(7840-7842)TGC>TGT	p.C2614C	FBN3_uc002mje.2_Silent_p.C410C	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2614	EGF-like 44; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11																		---	---	---	---
RAB11B	9230	broad.mit.edu	37	19	8464891	8464891	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8464891C>T	uc002mju.3	+	2	281	c.185C>T	c.(184-186)GCG>GTG	p.A62V	RAB11B_uc010xkd.1_Missense_Mutation_p.A62V	NM_004218	NP_004209	Q15907	RB11B_HUMAN	RAB11B, member RAS oncogene family	62					cell cycle|protein transport|small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity				0																		---	---	---	---
HNRNPM	4670	broad.mit.edu	37	19	8550915	8550915	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8550915G>A	uc010dwe.2	+	14	1683	c.1603G>A	c.(1603-1605)GCA>ACA	p.A535T	HNRNPM_uc010xke.1_Missense_Mutation_p.A481T|HNRNPM_uc010dwd.2_Missense_Mutation_p.A496T|HNRNPM_uc002mka.2_Missense_Mutation_p.A400T|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	535	27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0																		---	---	---	---
PRAM1	84106	broad.mit.edu	37	19	8555114	8555114	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8555114C>T	uc002mkd.2	-						PRAM1_uc002mkc.2_Intron	NM_032152	NP_115528			PML-RARA regulated adaptor molecule 1								lipid binding|protein binding				0																		---	---	---	---
PRAM1	84106	broad.mit.edu	37	19	8563898	8563898	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8563898T>C	uc002mkd.2	-	2	814	c.794A>G	c.(793-795)GAC>GGC	p.D265G	PRAM1_uc002mkc.2_Missense_Mutation_p.D265G	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	313	Pro-rich.						lipid binding|protein binding				0																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9049048	9049048	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9049048G>A	uc002mkp.2	-	5	32787	c.32583C>T	c.(32581-32583)TCC>TCT	p.S10861S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10863	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9069916	9069916	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9069916T>C	uc002mkp.2	-	3	17734	c.17530A>G	c.(17530-17532)ATC>GTC	p.I5844V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5846	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9074359	9074359	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9074359T>C	uc002mkp.2	-	3	13291	c.13087A>G	c.(13087-13089)ACC>GCC	p.T4363A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4365	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9074482	9074482	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9074482T>C	uc002mkp.2	-	3	13168	c.12964A>G	c.(12964-12966)ACA>GCA	p.T4322A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4324	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9091107	9091107	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9091107G>A	uc002mkp.2	-	1	912	c.708C>T	c.(706-708)TCC>TCT	p.S236S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	236	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
RDH8	50700	broad.mit.edu	37	19	10132286	10132286	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10132286C>T	uc002mmr.2	+	6	1046	c.797C>T	c.(796-798)ACG>ATG	p.T266M		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	266					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)													---	---	---	---
DNMT1	1786	broad.mit.edu	37	19	10252877	10252877	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10252877A>G	uc002mng.2	-	29	3268	c.3088T>C	c.(3088-3090)TCC>CCC	p.S1030P	DNMT1_uc002mne.2_5'Flank|DNMT1_uc002mnf.2_5'UTR|DNMT1_uc010xlc.1_Missense_Mutation_p.S1046P|DNMT1_uc002mnh.2_Missense_Mutation_p.S925P|DNMT1_uc010xld.1_Missense_Mutation_p.S1030P	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1030	BAH 2.				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)													---	---	---	---
DNMT1	1786	broad.mit.edu	37	19	10284549	10284549	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10284549T>C	uc002mng.2	-	7	813	c.633A>G	c.(631-633)GAA>GAG	p.E211E	DNMT1_uc010xlc.1_Silent_p.E227E|DNMT1_uc002mnh.2_Silent_p.E106E|DNMT1_uc010xld.1_Silent_p.E211E	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	211	Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)													---	---	---	---
ICAM1	3383	broad.mit.edu	37	19	10394791	10394791	+	Silent	SNP	C	T	T	rs143689328	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10394791C>T	uc002mnq.2	+	4	1039	c.720C>T	c.(718-720)GAC>GAT	p.D240D	ICAM1_uc010xle.1_Intron|ICAM4_uc002mnr.1_5'Flank|ICAM4_uc002mns.1_5'Flank|ICAM4_uc002mnt.1_5'Flank	NM_000201	NP_000192	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1 precursor	240	Ig-like C2-type 3.|Extracellular (Potential).				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)													---	---	---	---
TYK2	7297	broad.mit.edu	37	19	10475609	10475609	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10475609T>C	uc002moc.3	-	8	1505	c.1127A>G	c.(1126-1128)TAC>TGC	p.Y376C	TYK2_uc010dxe.2_Missense_Mutation_p.Y191C|TYK2_uc002mod.2_Missense_Mutation_p.Y376C	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	376	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)															---	---	---	---
KEAP1	9817	broad.mit.edu	37	19	10599954	10599954	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10599954G>A	uc002moq.1	-	5	1778	c.1622C>T	c.(1621-1623)ACA>ATA	p.T541I	KEAP1_uc002mop.1_Intron|KEAP1_uc002mor.1_Missense_Mutation_p.T541I	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	541	Kelch 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)															---	---	---	---
KEAP1	9817	broad.mit.edu	37	19	10602716	10602716	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10602716A>G	uc002moq.1	-	3	1018	c.862T>C	c.(862-864)TGC>CGC	p.C288R	KEAP1_uc002mop.1_Missense_Mutation_p.C6R|KEAP1_uc002mor.1_Missense_Mutation_p.C288R	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	288				C->S: Abolishes repression of NFE2L2- dependent gene expression. Slows down degradation of NFE2L2.	regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)															---	---	---	---
KRI1	65095	broad.mit.edu	37	19	10668217	10668217	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10668217G>A	uc002moy.1	-						KRI1_uc002mow.1_Intron|KRI1_uc002mox.1_Intron	NM_023008	NP_075384			KRI1 homolog											ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)															---	---	---	---
KRI1	65095	broad.mit.edu	37	19	10670352	10670352	+	Silent	SNP	G	A	A	rs139920982		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10670352G>A	uc002moy.1	-	11	987	c.978C>T	c.(976-978)TCC>TCT	p.S326S	KRI1_uc002mow.1_5'UTR|KRI1_uc002mox.1_Silent_p.S322S	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	326	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)															---	---	---	---
SMARCA4	6597	broad.mit.edu	37	19	11134301	11134301	+	Silent	SNP	C	T	T	rs149874634	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11134301C>T	uc002mqf.3	+	20	3251	c.2967C>T	c.(2965-2967)CCC>CCT	p.P989P	SMARCA4_uc010dxp.2_Silent_p.P989P|SMARCA4_uc010dxo.2_Silent_p.P989P|SMARCA4_uc002mqg.1_Silent_p.P989P|SMARCA4_uc010dxq.2_Silent_p.P989P|SMARCA4_uc010dxr.2_Silent_p.P989P|SMARCA4_uc002mqj.3_Silent_p.P989P|SMARCA4_uc010dxs.2_Silent_p.P989P|SMARCA4_uc010dxt.1_Silent_p.P209P|SMARCA4_uc002mqh.3_Silent_p.P112P|SMARCA4_uc002mqi.1_Silent_p.P192P	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	989					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)						F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				---	---	---	---
ZNF20	7568	broad.mit.edu	37	19	12243602	12243602	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12243602G>A	uc002mtf.1	-	4	1542	c.1399C>T	c.(1399-1401)CGA>TGA	p.R467*	ZNF20_uc002mte.1_Nonsense_Mutation_p.R432*|ZNF20_uc002mtg.1_Nonsense_Mutation_p.R467*	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	467	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF799	90576	broad.mit.edu	37	19	12501728	12501728	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12501728C>T	uc010dyt.2	-	4	1634	c.1484G>A	c.(1483-1485)AGA>AAA	p.R495K	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	495	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6																		---	---	---	---
ZNF799	90576	broad.mit.edu	37	19	12501734	12501734	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12501734T>C	uc010dyt.2	-	4	1628	c.1478A>G	c.(1477-1479)CAA>CGA	p.Q493R	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	493	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6																		---	---	---	---
ZNF443	10224	broad.mit.edu	37	19	12541723	12541723	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12541723A>G	uc002mtu.2	-	4	1461	c.1263T>C	c.(1261-1263)CAT>CAC	p.H421H		NM_005815	NP_005806	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	421	C2H2-type 11.				induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1																		---	---	---	---
MAN2B1	4125	broad.mit.edu	37	19	12758258	12758258	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12758258C>A	uc002mub.2	-	22	2895	c.2819G>T	c.(2818-2820)AGG>ATG	p.R940M	MAN2B1_uc010dyv.1_Missense_Mutation_p.R939M	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	940					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6																		---	---	---	---
ASNA1	439	broad.mit.edu	37	19	12858200	12858200	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12858200G>A	uc002muv.2	+						ASNA1_uc002muw.2_Intron	NM_004317	NP_004308			arsA arsenite transporter, ATP-binding, homolog						response to arsenic-containing substance	endoplasmic reticulum|nucleolus|soluble fraction	arsenite-transporting ATPase activity|ATP binding|metal ion binding			ovary(2)	2					Adenosine triphosphate(DB00171)													---	---	---	---
HOOK2	29911	broad.mit.edu	37	19	12882282	12882282	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12882282A>G	uc002muy.2	-	8	700	c.529T>C	c.(529-531)TAC>CAC	p.Y177H	HOOK2_uc002muz.2_Missense_Mutation_p.Y177H	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	177	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
FARSA	2193	broad.mit.edu	37	19	13035921	13035921	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13035921G>A	uc002mvs.2	-	8	957	c.909C>T	c.(907-909)GGC>GGT	p.G303G	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Silent_p.G272G|FARSA_uc010dyy.1_Silent_p.G224G	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	303					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)													---	---	---	---
RAD23A	5886	broad.mit.edu	37	19	13059009	13059009	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13059009A>G	uc002mvw.1	+	3	362	c.253A>G	c.(253-255)ACC>GCC	p.T85A	RAD23A_uc002mvx.1_Missense_Mutation_p.T85A|RAD23A_uc002mvz.1_Missense_Mutation_p.T85A|RAD23A_uc002mwa.1_Missense_Mutation_p.T85A|RAD23A_uc002mvy.1_5'UTR|RAD23A_uc010xmw.1_5'UTR	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	85					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1													NER					---	---	---	---
DAND5	199699	broad.mit.edu	37	19	13084403	13084403	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13084403A>G	uc002mwc.1	+	2	568	c.525A>G	c.(523-525)ATA>ATG	p.I175M	DAND5_uc010dyz.1_3'UTR	NM_152654	NP_689867	Q8N907	DAND5_HUMAN	dante precursor	175	CTCK.					extracellular region				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)															---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13323264	13323264	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13323264C>A	uc010dze.2	-	42	6362	c.6126G>T	c.(6124-6126)AAG>AAT	p.K2042N	CACNA1A_uc010xnd.1_Missense_Mutation_p.K747N|CACNA1A_uc002mwx.3_Missense_Mutation_p.K747N|CACNA1A_uc010dzc.2_Missense_Mutation_p.K1567N|CACNA1A_uc002mwy.3_Missense_Mutation_p.K2041N|CACNA1A_uc002mwv.3_Missense_Mutation_p.K558N	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	2042	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)													---	---	---	---
MRI1	84245	broad.mit.edu	37	19	13879676	13879676	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13879676G>A	uc002mxe.2	+	5	829	c.763G>A	c.(763-765)GAC>AAC	p.D255N	MRI1_uc002mxf.2_Missense_Mutation_p.D208N	NM_001031727	NP_001026897	Q9BV20	MTNA_HUMAN	translation initiation factor eIF-2B subunit	255					L-methionine salvage from methylthioadenosine	cell projection|cytoplasm|nucleus	identical protein binding|S-methyl-5-thioribose-1-phosphate isomerase activity			ovary(1)	1																		---	---	---	---
C19orf53	28974	broad.mit.edu	37	19	13885340	13885340	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13885340A>G	uc002mxg.2	+	1	84	c.49A>G	c.(49-51)AAG>GAG	p.K17E		NM_014047	NP_054766	Q9UNZ5	L10K_HUMAN	Leydig cell tumor 10 kDa protein	17										ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;7.7e-24)|Epithelial(5;2.53e-19)															---	---	---	---
ZSWIM4	65249	broad.mit.edu	37	19	13941371	13941371	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13941371C>T	uc002mxh.1	+	13	2666	c.2477C>T	c.(2476-2478)ACG>ATG	p.T826M	ZSWIM4_uc010xng.1_Missense_Mutation_p.T749M	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	826							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)															---	---	---	---
CC2D1A	54862	broad.mit.edu	37	19	14040219	14040219	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14040219T>C	uc002mxo.2	+	25	2846	c.2547T>C	c.(2545-2547)AGT>AGC	p.S849S	CC2D1A_uc002mxp.2_Silent_p.S848S|CC2D1A_uc010dzh.2_Silent_p.S418S	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	849					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)															---	---	---	---
IL27RA	9466	broad.mit.edu	37	19	14143218	14143218	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14143218T>C	uc002mxx.2	+	2	544	c.121T>C	c.(121-123)TGC>CGC	p.C41R		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	41	Extracellular (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0																		---	---	---	---
ASF1B	55723	broad.mit.edu	37	19	14232432	14232432	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14232432T>C	uc002mye.2	-	3	486	c.314A>G	c.(313-315)GAG>GGG	p.E105G		NM_018154	NP_060624	Q9NVP2	ASF1B_HUMAN	anti-silencing function 1B	105	Interaction with CHAF1B.|Interaction with histone H3 (By similarity).				cell differentiation|chromatin modification|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus					0																		---	---	---	---
LPHN1	22859	broad.mit.edu	37	19	14268255	14268255	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14268255G>A	uc010xnn.1	-	15	2864	c.2568C>T	c.(2566-2568)AAC>AAT	p.N856N	LPHN1_uc010xno.1_Silent_p.N851N|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	856	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5																		---	---	---	---
CD97	976	broad.mit.edu	37	19	14501875	14501875	+	Silent	SNP	C	T	T	rs140836731	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14501875C>T	uc002myl.2	+	4	453	c.330C>T	c.(328-330)AGC>AGT	p.S110S	CD97_uc002mym.2_Silent_p.S110S|CD97_uc002myn.2_Silent_p.S110S	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	110	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
PKN1	5585	broad.mit.edu	37	19	14554341	14554341	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14554341G>A	uc002myp.2	+	3	550	c.382G>A	c.(382-384)GTG>ATG	p.V128M	PKN1_uc002myq.2_Missense_Mutation_p.V134M	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	128	REM 2.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
PKN1	5585	broad.mit.edu	37	19	14580254	14580254	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14580254T>C	uc002myp.2	+	16	2246	c.2078T>C	c.(2077-2079)TTC>TCC	p.F693S	PKN1_uc002myq.2_Missense_Mutation_p.F699S|PKN1_uc002myr.2_Missense_Mutation_p.F33S	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	693	Protein kinase.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
DNAJB1	3337	broad.mit.edu	37	19	14629004	14629004	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14629004T>C	uc002myz.1	-	1	198	c.158A>G	c.(157-159)GAC>GGC	p.D53G	DNAJB1_uc010xnr.1_Intron	NM_006145	NP_006136	P25685	DNJB1_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 1	53	J.				chaperone cofactor-dependent protein refolding|response to unfolded protein	cytoplasm|nucleolus	heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(1328;0.0476)														---	---	---	---
OR7A10	390892	broad.mit.edu	37	19	14952342	14952342	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14952342G>A	uc002mzx.1	-	1	348	c.348C>T	c.(346-348)ACC>ACT	p.T116T		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)																	---	---	---	---
NOTCH3	4854	broad.mit.edu	37	19	15271701	15271701	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15271701G>T	uc002nan.2	-	33	6814	c.6738C>A	c.(6736-6738)ACC>ACA	p.T2246T		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	2246	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)															---	---	---	---
NOTCH3	4854	broad.mit.edu	37	19	15302962	15302962	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15302962C>T	uc002nan.2	-	4	564	c.488G>A	c.(487-489)CGG>CAG	p.R163Q	NOTCH3_uc002nao.1_Missense_Mutation_p.R163Q	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	163	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)															---	---	---	---
BRD4	23476	broad.mit.edu	37	19	15376427	15376427	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15376427A>G	uc002nar.2	-	5	809	c.587T>C	c.(586-588)GTA>GCA	p.V196A	BRD4_uc002nas.2_Missense_Mutation_p.V196A|BRD4_uc002nat.3_Missense_Mutation_p.V196A|BRD4_uc002nau.3_Missense_Mutation_p.V196A	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	196					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)					T	NUT|C15orf55	lethal midline carcinoma of young people								---	---	---	---
AKAP8	10270	broad.mit.edu	37	19	15465764	15465764	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15465764T>C	uc002nav.2	-	14	2102	c.2041A>G	c.(2041-2043)ACT>GCT	p.T681A	AKAP8_uc010dzy.2_Missense_Mutation_p.T230A	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	681					signal transduction	nuclear matrix				ovary(1)|breast(1)	2																		---	---	---	---
AKAP8	10270	broad.mit.edu	37	19	15479061	15479061	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15479061T>C	uc002nav.2	-	9	1206	c.1145A>G	c.(1144-1146)GAC>GGC	p.D382G	AKAP8_uc010dzy.2_5'UTR|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_Missense_Mutation_p.D196G	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	382					signal transduction	nuclear matrix				ovary(1)|breast(1)	2																		---	---	---	---
OR10H2	26538	broad.mit.edu	37	19	15839069	15839069	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15839069C>T	uc002nbm.2	+	1	236	c.216C>T	c.(214-216)CTC>CTT	p.L72L		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)																	---	---	---	---
AP1M1	8907	broad.mit.edu	37	19	16319907	16319907	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16319907C>T	uc002ndu.2	+	5	638	c.465C>T	c.(463-465)AAC>AAT	p.N155N	AP1M1_uc002ndv.2_Silent_p.N155N|AP1M1_uc010xpd.1_Silent_p.N155N	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	155					cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4																		---	---	---	---
CALR3	125972	broad.mit.edu	37	19	16596064	16596064	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16596064G>A	uc002ned.2	-	4	465	c.402C>T	c.(400-402)CCC>CCT	p.P134P	MED26_uc002nee.2_Intron	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3 precursor	134	N-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0																		---	---	---	---
MED26	9441	broad.mit.edu	37	19	16686833	16686833	+	3'UTR	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16686833G>T	uc002nen.1	-	3					MED26_uc002nee.2_Intron	NM_004831	NP_004822			mediator complex subunit 26						regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2																		---	---	---	---
MED26	9441	broad.mit.edu	37	19	16688193	16688193	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16688193G>A	uc002nen.1	-	3	709	c.448C>T	c.(448-450)CGG>TGG	p.R150W	MED26_uc002nee.2_RNA	NM_004831	NP_004822	O95402	MED26_HUMAN	mediator complex subunit 26	150					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			ovary(2)	2																		---	---	---	---
SIN3B	23309	broad.mit.edu	37	19	16942437	16942437	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16942437A>G	uc002ney.1	+	3	374	c.360A>G	c.(358-360)ATA>ATG	p.I120M	SIN3B_uc002new.2_Missense_Mutation_p.I120M|SIN3B_uc002nex.2_Missense_Mutation_p.I52M|SIN3B_uc002nez.1_Missense_Mutation_p.I120M	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	120					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17039982	17039982	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17039982G>A	uc002nfb.2	-	24	3087	c.3055C>T	c.(3055-3057)CGC>TGC	p.R1019C		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	972						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
CPAMD8	27151	broad.mit.edu	37	19	17081839	17081839	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17081839G>A	uc002nfb.2	-	18	2248	c.2216C>T	c.(2215-2217)ACG>ATG	p.T739M		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	692						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13																		---	---	---	---
MYO9B	4650	broad.mit.edu	37	19	17312954	17312954	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17312954G>A	uc010eak.2	+	28	4830	c.4678G>A	c.(4678-4680)GTG>ATG	p.V1560M	MYO9B_uc002nfi.2_Missense_Mutation_p.V1560M|MYO9B_uc002nfj.1_Missense_Mutation_p.V1560M|MYO9B_uc002nfl.1_Missense_Mutation_p.V109M	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1560	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1																		---	---	---	---
ANKLE1	126549	broad.mit.edu	37	19	17394238	17394238	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17394238T>C	uc002nga.2	+	5	941	c.665T>C	c.(664-666)GTC>GCC	p.V222A	ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_Missense_Mutation_p.V244A|ANKLE1_uc010xpn.1_Missense_Mutation_p.V276A|ANKLE1_uc002nfy.2_Missense_Mutation_p.V211A|ANKLE1_uc002nfz.2_5'UTR	NM_152363	NP_689576	Q8NAG6	ANKL1_HUMAN	ankyrin repeat domain 41	222						nuclear envelope					0																		---	---	---	---
ANKLE1	126549	broad.mit.edu	37	19	17397362	17397362	+	3'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17397362G>A	uc002nga.2	+	9					ANKLE1_uc010xpm.1_RNA|ANKLE1_uc010eao.1_3'UTR|ANKLE1_uc010xpn.1_Silent_p.E598E|ANKLE1_uc002nfy.2_3'UTR|ANKLE1_uc002nfz.2_3'UTR	NM_152363	NP_689576			ankyrin repeat domain 41							nuclear envelope					0																		---	---	---	---
FAM129C	199786	broad.mit.edu	37	19	17653018	17653018	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17653018G>A	uc010xpr.1	+	11	1475	c.1337G>A	c.(1336-1338)CGG>CAG	p.R446Q	FAM129C_uc010xpq.1_Missense_Mutation_p.R446Q|FAM129C_uc002ngy.3_Missense_Mutation_p.R172Q|FAM129C_uc010xpu.1_Missense_Mutation_p.R172Q|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_Missense_Mutation_p.R172Q|FAM129C_uc002nhb.2_Missense_Mutation_p.R45Q	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	446											0																		---	---	---	---
GLT25D1	79709	broad.mit.edu	37	19	17679457	17679457	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17679457C>A	uc002nhc.1	+	5	776	c.764C>A	c.(763-765)CCT>CAT	p.P255H	GLT25D1_uc010eax.1_Missense_Mutation_p.P23H	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	255					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17750650	17750650	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17750650C>T	uc002nhd.2	-	23	3119	c.3119G>A	c.(3118-3120)CGG>CAG	p.R1040Q		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	952					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
FCHO1	23149	broad.mit.edu	37	19	17885203	17885203	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17885203C>T	uc010ebb.2	+	12	1025	c.836C>T	c.(835-837)GCG>GTG	p.A279V	FCHO1_uc002nhg.3_Missense_Mutation_p.A279V|FCHO1_uc002nhh.2_Missense_Mutation_p.A279V|FCHO1_uc010xpw.1_Missense_Mutation_p.A229V|FCHO1_uc010ebc.1_Missense_Mutation_p.A286V	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	279										breast(1)	1																		---	---	---	---
RPL18A	6142	broad.mit.edu	37	19	17973010	17973010	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17973010C>A	uc002nhp.1	+	3	341	c.306C>A	c.(304-306)ACC>ACA	p.T102T	SNORA68_uc002nhq.1_5'Flank	NM_000980	NP_000971	Q02543	RL18A_HUMAN	ribosomal protein L18a	102					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0																		---	---	---	---
MAST3	23031	broad.mit.edu	37	19	18252739	18252739	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18252739C>T	uc002nhz.3	+	20	2166	c.2166C>T	c.(2164-2166)TTC>TTT	p.F722F		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	722							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5																		---	---	---	---
PIK3R2	5296	broad.mit.edu	37	19	18274130	18274130	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18274130C>T	uc002nia.1	+	11	1860	c.1348C>T	c.(1348-1350)CAC>TAC	p.H450Y	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	450					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
PIK3R2	5296	broad.mit.edu	37	19	18279691	18279691	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18279691A>G	uc002nia.1	+	15	2476	c.1964A>G	c.(1963-1965)TAC>TGC	p.Y655C	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	655	SH2 2.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
IFI30	10437	broad.mit.edu	37	19	18288041	18288041	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18288041C>T	uc002nic.1	+	5	648	c.575C>T	c.(574-576)GCC>GTC	p.A192V	PIK3R2_uc002nib.1_RNA	NM_006332	NP_006323	P13284	GILT_HUMAN	interferon, gamma-inducible protein 30	192					antigen processing and presentation of exogenous peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway	cell junction|extracellular region|lysosome	oxidoreductase activity, acting on a sulfur group of donors				0																		---	---	---	---
SSBP4	170463	broad.mit.edu	37	19	18543405	18543405	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18543405T>C	uc002niy.2	+	11	979	c.741T>C	c.(739-741)AGT>AGC	p.S247S	SSBP4_uc002niz.2_Silent_p.S225S	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4 isoform a	247	Pro-rich.					nucleus	single-stranded DNA binding				0																		---	---	---	---
ELL	8178	broad.mit.edu	37	19	18557206	18557206	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18557206C>T	uc002njh.2	-	10	1689	c.1617G>A	c.(1615-1617)CTG>CTA	p.L539L	ELL_uc010ebq.2_Silent_p.L482L|ELL_uc002njg.2_Silent_p.L406L	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	539					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)				T	MLL	AL								---	---	---	---
FKBP8	23770	broad.mit.edu	37	19	18648475	18648475	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18648475C>T	uc002njk.1	-	6	991	c.878G>A	c.(877-879)CGC>CAC	p.R293H	FKBP8_uc002nji.1_Missense_Mutation_p.R131H|FKBP8_uc010xqi.1_Missense_Mutation_p.R322H|FKBP8_uc002njj.1_Missense_Mutation_p.R294H|FKBP8_uc002njl.1_Missense_Mutation_p.R294H|FKBP8_uc002njm.1_Missense_Mutation_p.R293H|FKBP8_uc010ebr.1_Missense_Mutation_p.R132H|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	293	TPR 2.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1																		---	---	---	---
CRTC1	23373	broad.mit.edu	37	19	18886579	18886579	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18886579G>A	uc002nkb.3	+	13	1729	c.1641G>A	c.(1639-1641)TCG>TCA	p.S547S	CRTC1_uc010ebv.2_Silent_p.S563S|CRTC1_uc010ebw.2_Silent_p.S383S|CRTC1_uc002nkc.3_Silent_p.S245S	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	547					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding	p.S547S(1)	CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519																		---	---	---	---
COMP	1311	broad.mit.edu	37	19	18893913	18893913	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18893913G>A	uc002nke.2	-	18	2214	c.2178C>T	c.(2176-2178)TGC>TGT	p.C726C	COMP_uc002nkd.2_Silent_p.C693C|COMP_uc010xqj.1_Silent_p.C673C	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	726	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0																		---	---	---	---
MEF2B	100271849	broad.mit.edu	37	19	19260114	19260114	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19260114G>A	uc002nlm.2	-	3	293	c.179C>T	c.(178-180)ACG>ATG	p.T60M	MEF2B_uc002nln.2_Missense_Mutation_p.T107M|MEF2B_uc002nll.2_Missense_Mutation_p.T60M|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.T60M|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.T60M|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.T60M|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.T60M|MEF2B_uc002nlk.2_Missense_Mutation_p.T60M	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)															---	---	---	---
RFXANK	8625	broad.mit.edu	37	19	19308408	19308408	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19308408C>T	uc002nls.2	+	6	921	c.416C>T	c.(415-417)ACC>ATC	p.T139I	RFXANK_uc002nlt.2_Missense_Mutation_p.T116I|RFXANK_uc002nlu.2_Missense_Mutation_p.T117I|RFXANK_uc002nlv.2_Missense_Mutation_p.T139I|RFXANK_uc002nlw.2_Missense_Mutation_p.T138I	NM_003721	NP_003712	O14593	RFXK_HUMAN	regulatory factor X-associated	139	ANK 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2			Epithelial(12;0.00228)															---	---	---	---
KIAA0892	23383	broad.mit.edu	37	19	19460214	19460214	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19460214G>A	uc002nmk.3	+	16	1556	c.1517G>A	c.(1516-1518)GGC>GAC	p.G506D	KIAA0892_uc002nml.3_Missense_Mutation_p.G111D|KIAA0892_uc010ecd.2_Missense_Mutation_p.G111D|KIAA0892_uc010ece.2_Missense_Mutation_p.G82D	NM_015329	NP_056144	Q9Y6X3	SCC4_HUMAN	hypothetical protein LOC23383 precursor	506	TPR 4.				cell division|maintenance of mitotic sister chromatid cohesion	chromatin|nucleoplasm|SMC loading complex	protein N-terminus binding				0																		---	---	---	---
GATAD2A	54815	broad.mit.edu	37	19	19611975	19611975	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19611975G>A	uc010xqt.1	+	9	1562	c.1250G>A	c.(1249-1251)TGT>TAT	p.C417Y	GATAD2A_uc010xqu.1_Missense_Mutation_p.C46Y|GATAD2A_uc010xqv.1_Missense_Mutation_p.C437Y|GATAD2A_uc010xqw.1_Missense_Mutation_p.C245Y	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	417	GATA-type.				DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
GATAD2A	54815	broad.mit.edu	37	19	19613341	19613341	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19613341T>C	uc010xqt.1	+						GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Intron|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130			GATA zinc finger domain containing 2A						DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
NDUFA13	51079	broad.mit.edu	37	19	19640291	19640291	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19640291C>T	uc010xqy.1	+						NDUFA13_uc010xqx.1_Nonsense_Mutation_p.Q265*|YJEFN3_uc002nmt.1_Nonsense_Mutation_p.Q60*|YJEFN3_uc010ecf.1_Intron|YJEFN3_uc002nmu.1_Intron	NM_015965	NP_057049			NADH dehydrogenase (ubiquinone) 1 alpha						apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)													---	---	---	---
ZNF101	94039	broad.mit.edu	37	19	19788767	19788767	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19788767C>T	uc002nni.1	+	2	208	c.98C>T	c.(97-99)ACG>ATG	p.T33M	ZNF101_uc010ecg.1_Translation_Start_Site|ZNF101_uc002nnj.1_Translation_Start_Site	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
ZNF101	94039	broad.mit.edu	37	19	19790797	19790797	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19790797T>C	uc002nni.1	+	4	1109	c.999T>C	c.(997-999)ACT>ACC	p.T333T	ZNF101_uc010ecg.1_Silent_p.T213T|ZNF101_uc002nnj.1_Silent_p.T213T	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	zinc finger protein 101	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
ZNF682	91120	broad.mit.edu	37	19	20117187	20117187	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20117187T>C	uc002noq.2	-	4	1247	c.1124A>G	c.(1123-1125)GAC>GGC	p.D375G	ZNF682_uc002noo.2_Missense_Mutation_p.D343G|ZNF682_uc002nop.2_Missense_Mutation_p.D343G|ZNF682_uc010eck.2_Missense_Mutation_p.D299G	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	375	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
ZNF486	90649	broad.mit.edu	37	19	20308530	20308530	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20308530T>C	uc002nou.2	+	4	1068	c.1011T>C	c.(1009-1011)CTT>CTC	p.L337L		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	337	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF430	80264	broad.mit.edu	37	19	21240516	21240516	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21240516C>T	uc002npj.2	+	5	1512	c.1402C>T	c.(1402-1404)CGG>TGG	p.R468W	ZNF430_uc002npk.2_Missense_Mutation_p.R467W	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	468	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2																		---	---	---	---
ZNF714	148206	broad.mit.edu	37	19	21299731	21299731	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21299731A>G	uc002npo.3	+	5	621	c.261A>G	c.(259-261)AAA>AAG	p.K87K	ZNF714_uc002npl.2_5'UTR|ZNF714_uc010ecp.1_Silent_p.K39K|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF714	148206	broad.mit.edu	37	19	21300315	21300315	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21300315A>G	uc002npo.3	+	6	1208	c.848A>G	c.(847-849)AAA>AGA	p.K283R	ZNF714_uc002npl.2_Missense_Mutation_p.K128R|ZNF714_uc010ecp.1_Missense_Mutation_p.K234R|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF708	7562	broad.mit.edu	37	19	21477133	21477133	+	Missense_Mutation	SNP	G	A	A	rs148687204	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21477133G>A	uc002npq.1	-	4	833	c.635C>T	c.(634-636)ACG>ATG	p.T212M	ZNF708_uc002npr.1_Missense_Mutation_p.T148M|ZNF708_uc010ecs.1_Missense_Mutation_p.T148M	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	212	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6																		---	---	---	---
ZNF493	284443	broad.mit.edu	37	19	21606088	21606088	+	Silent	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21606088T>G	uc002npx.2	+	2	523	c.243T>G	c.(241-243)TCT>TCG	p.S81S	ZNF493_uc002npw.2_Silent_p.S209S|ZNF493_uc002npy.2_Silent_p.S81S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF493	284443	broad.mit.edu	37	19	21606418	21606418	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21606418A>G	uc002npx.2	+	2	853	c.573A>G	c.(571-573)AAA>AAG	p.K191K	ZNF493_uc002npw.2_Silent_p.K319K|ZNF493_uc002npy.2_Silent_p.K191K	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF43	7594	broad.mit.edu	37	19	21991830	21991830	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21991830T>C	uc002nqj.2	-	4	1139	c.1009A>G	c.(1009-1011)ACT>GCT	p.T337A	ZNF43_uc010ecv.2_Missense_Mutation_p.T331A|ZNF43_uc002nql.2_Missense_Mutation_p.T331A|ZNF43_uc002nqm.2_Missense_Mutation_p.T331A|ZNF43_uc002nqk.2_Missense_Mutation_p.T267A	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)														---	---	---	---
ZNF208	7757	broad.mit.edu	37	19	22156465	22156465	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22156465T>C	uc002nqp.2	-	4	1520	c.1371A>G	c.(1369-1371)GAA>GAG	p.E457E	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_Splice_Site	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF257	113835	broad.mit.edu	37	19	22270970	22270970	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22270970A>G	uc010ecx.2	+	4	587	c.418A>G	c.(418-420)ACC>GCC	p.T140A	ZNF257_uc010ecy.2_Missense_Mutation_p.T108A	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF257	113835	broad.mit.edu	37	19	22271493	22271493	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22271493A>G	uc010ecx.2	+	4	1110	c.941A>G	c.(940-942)AAA>AGA	p.K314R	ZNF257_uc010ecy.2_Missense_Mutation_p.K282R	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)																---	---	---	---
ZNF676	163223	broad.mit.edu	37	19	22363694	22363694	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22363694A>G	uc002nqs.1	-	3	1143	c.825T>C	c.(823-825)CAT>CAC	p.H275H		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	275	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)																---	---	---	---
ZNF91	7644	broad.mit.edu	37	19	23544026	23544026	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23544026A>G	uc002nre.2	-	4	1868	c.1755T>C	c.(1753-1755)CAT>CAC	p.H585H	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Silent_p.H553H	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	585	C2H2-type 16.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)																---	---	---	---
C19orf12	83636	broad.mit.edu	37	19	30199167	30199167	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30199167C>T	uc002nsk.2	-	2	585	c.154G>A	c.(154-156)GCC>ACC	p.A52T	C19orf12_uc002nsj.2_Missense_Mutation_p.A63T|C19orf12_uc002nsl.2_Intron|C19orf12_uc002nsm.2_RNA	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	52	Helical; (Potential).					integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)															---	---	---	---
ZNF536	9745	broad.mit.edu	37	19	30935840	30935840	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30935840G>A	uc002nsu.1	+	2	1509	c.1371G>A	c.(1369-1371)GAG>GAA	p.E457E	ZNF536_uc010edd.1_Silent_p.E457E	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)																	---	---	---	---
RHPN2	85415	broad.mit.edu	37	19	33471032	33471032	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33471032C>T	uc002nuf.2	-	15	1997	c.1931G>A	c.(1930-1932)GGC>GAC	p.G644D	RHPN2_uc010xro.1_Missense_Mutation_p.G493D|RHPN2_uc002nue.2_Missense_Mutation_p.G374D	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	644					signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)																	---	---	---	---
WDR88	126248	broad.mit.edu	37	19	33647305	33647305	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33647305G>A	uc002nui.2	+	7	932	c.854G>A	c.(853-855)GGC>GAC	p.G285D		NM_173479	NP_775750	Q6ZMY6	WDR88_HUMAN	PQQ repeat and WD repeat domain containing	285	WD 5.									ovary(1)|breast(1)|central_nervous_system(1)	3	Esophageal squamous(110;0.137)																	---	---	---	---
LRP3	4037	broad.mit.edu	37	19	33693826	33693826	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33693826A>G	uc010edh.2	+	3	287	c.194A>G	c.(193-195)AAC>AGC	p.N65S	LRP3_uc010xrp.1_5'UTR|LRP3_uc002nuk.3_5'Flank	NM_002333	NP_002324	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein	65	Extracellular (Potential).|CUB 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			pancreas(2)|ovary(1)	3	Esophageal squamous(110;0.137)																	---	---	---	---
SLC7A10	56301	broad.mit.edu	37	19	33700230	33700230	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33700230A>G	uc002num.2	-	10	1572	c.1425T>C	c.(1423-1425)TGT>TGC	p.C475C	SLC7A10_uc002nul.2_Silent_p.C322C	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	475					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34818956	34818956	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34818956T>C	uc002nvd.3	+	6	1863	c.1004T>C	c.(1003-1005)ATG>ACG	p.M335T		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	335										ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
MAG	4099	broad.mit.edu	37	19	35786812	35786812	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35786812T>C	uc002nyy.1	+	4	492	c.343T>C	c.(343-345)TAC>CAC	p.Y115H	MAG_uc002nyx.1_Missense_Mutation_p.Y115H|MAG_uc010eds.1_Missense_Mutation_p.Y90H|MAG_uc002nyz.1_Missense_Mutation_p.Y115H	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	115	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)															---	---	---	---
MAG	4099	broad.mit.edu	37	19	35800929	35800929	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35800929T>C	uc002nyy.1	+	8	1533	c.1384T>C	c.(1384-1386)TAC>CAC	p.Y462H	MAG_uc002nyx.1_Missense_Mutation_p.Y462H|MAG_uc010eds.1_Missense_Mutation_p.Y437H|MAG_uc002nyz.1_Missense_Mutation_p.Y462H	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	462	Ig-like C2-type 4.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)															---	---	---	---
CD22	933	broad.mit.edu	37	19	35828763	35828763	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35828763C>T	uc010edt.2	+	5	901	c.824C>T	c.(823-825)ACG>ATG	p.T275M	CD22_uc010xst.1_Missense_Mutation_p.T103M|CD22_uc010edu.2_Missense_Mutation_p.T275M|CD22_uc010edv.2_Missense_Mutation_p.T275M|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	275	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)													---	---	---	---
GAPDHS	26330	broad.mit.edu	37	19	36024441	36024441	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36024441C>T	uc002oaf.1	+	1	128	c.12C>T	c.(10-12)CGC>CGT	p.R4R		NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	4					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)													---	---	---	---
ATP4A	495	broad.mit.edu	37	19	36047837	36047837	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36047837T>C	uc002oal.1	-	12	1876	c.1847A>G	c.(1846-1848)AAG>AGG	p.K616R	ATP4A_uc010eee.1_Intron	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	616	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)													---	---	---	---
ATP4A	495	broad.mit.edu	37	19	36049992	36049992	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36049992C>T	uc002oal.1	-	8	1187	c.1158G>A	c.(1156-1158)TCG>TCA	p.S386S	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	386	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)													---	---	---	---
HAUS5	23354	broad.mit.edu	37	19	36108753	36108753	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36108753A>G	uc002oam.1	+							NM_015302	NP_056117			HAUS augmin-like complex, subunit 5						cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0																		---	---	---	---
ZBTB32	27033	broad.mit.edu	37	19	36207454	36207454	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36207454A>G	uc002oay.2	+	6	1474	c.1264A>G	c.(1264-1266)ACA>GCA	p.T422A	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	422	C2H2-type 2.				DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)													OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PSENEN	55851	broad.mit.edu	37	19	36236883	36236883	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36236883T>C	uc002obi.1	+	2	256	c.52T>C	c.(52-54)TAC>CAC	p.Y18H	TMEM149_uc010eej.2_5'Flank|U2AF1L4_uc002obh.1_5'Flank|U2AF1L4_uc002obe.2_5'Flank|U2AF1L4_uc002obf.2_5'Flank|U2AF1L4_uc002obg.2_5'Flank|PSENEN_uc002obj.1_Missense_Mutation_p.Y18H|PSENEN_uc002obk.1_RNA|LIN37_uc002obm.2_5'Flank	NM_172341	NP_758844	Q9NZ42	PEN2_HUMAN	presenilin enhancer 2	18	Helical; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	aspartic-type endopeptidase activity|protein binding			ovary(2)	2	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
LIN37	55957	broad.mit.edu	37	19	36245365	36245365	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36245365A>G	uc002obm.2	+	10	845	c.731A>G	c.(730-732)GAA>GGA	p.E244G	uc002obl.2_5'Flank	NM_019104	NP_061977	Q96GY3	LIN37_HUMAN	lin-37 homolog	244							protein binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
NPHS1	4868	broad.mit.edu	37	19	36336323	36336323	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36336323T>C	uc002oby.2	-	14	1877	c.1877A>G	c.(1876-1878)CAC>CGC	p.H626R		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	626	Ig-like C2-type 6.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
KIRREL2	84063	broad.mit.edu	37	19	36352822	36352822	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36352822T>C	uc002ocb.3	+	11	1618	c.1406T>C	c.(1405-1407)CTA>CCA	p.L469P	KIRREL2_uc002obz.3_Missense_Mutation_p.L469P|KIRREL2_uc002oca.3_Missense_Mutation_p.L419P|KIRREL2_uc002occ.3_Missense_Mutation_p.L416P|KIRREL2_uc002ocd.3_Missense_Mutation_p.L466P	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	469	Ig-like C2-type 5.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
KIRREL2	84063	broad.mit.edu	37	19	36357201	36357201	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36357201A>G	uc002ocb.3	+	15	2146	c.1934A>G	c.(1933-1935)CAC>CGC	p.H645R	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Missense_Mutation_p.H592R|KIRREL2_uc002ocd.3_Missense_Mutation_p.H607R|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	645	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
CLIP3	25999	broad.mit.edu	37	19	36517143	36517143	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36517143A>G	uc010eeq.1	-	5	869	c.587T>C	c.(586-588)TTC>TCC	p.F196S	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.F196S	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	196					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
WDR62	284403	broad.mit.edu	37	19	36595572	36595572	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36595572C>T	uc002odc.2	+	31	4382	c.4291C>T	c.(4291-4293)CGT>TGT	p.R1431C	WDR62_uc002odd.2_Missense_Mutation_p.R1436C	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1431					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
ZNF565	147929	broad.mit.edu	37	19	36673869	36673869	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36673869T>C	uc002odn.2	-	5	1107	c.999A>G	c.(997-999)AAA>AAG	p.K333K	ZNF565_uc010ees.2_Silent_p.K268K|ZNF565_uc002odo.2_Silent_p.K333K	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)															---	---	---	---
ZFP14	57677	broad.mit.edu	37	19	36831647	36831647	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36831647T>C	uc002odx.1	-	4	1174	c.1081A>G	c.(1081-1083)ATT>GTT	p.I361V	ZFP14_uc010xtd.1_Missense_Mutation_p.I362V|ZFP14_uc010eex.1_Missense_Mutation_p.I361V	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
ZNF529	57711	broad.mit.edu	37	19	37038880	37038880	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37038880T>C	uc002oeh.3	-	5	782	c.580A>G	c.(580-582)ACT>GCT	p.T194A	ZNF529_uc010xth.1_Missense_Mutation_p.T194A|ZNF529_uc010xti.1_Missense_Mutation_p.T176A|ZNF529_uc002oeg.3_Missense_Mutation_p.T89A	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)																	---	---	---	---
ZNF345	25850	broad.mit.edu	37	19	37368485	37368485	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37368485T>G	uc002oex.2	+	3	1131	c.753T>G	c.(751-753)ATT>ATG	p.I251M	ZNF345_uc002oey.3_Missense_Mutation_p.I251M|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	251	C2H2-type 7.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF829	374899	broad.mit.edu	37	19	37382950	37382950	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37382950G>A	uc002ofa.1	-	6	1105	c.743C>T	c.(742-744)GCC>GTC	p.A248V	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	248	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF420	147923	broad.mit.edu	37	19	37619822	37619822	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37619822T>C	uc002ofl.2	+	5	2144	c.1929T>C	c.(1927-1929)TAT>TAC	p.Y643Y		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	643	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
ZNF527	84503	broad.mit.edu	37	19	37879579	37879579	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:37879579A>G	uc010efk.1	+	5	739	c.628A>G	c.(628-630)AAA>GAA	p.K210E	ZNF527_uc002ogf.3_Missense_Mutation_p.K178E|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
SIPA1L3	23094	broad.mit.edu	37	19	38579367	38579367	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38579367C>T	uc002ohk.2	+	4	2050	c.1541C>T	c.(1540-1542)GCC>GTC	p.A514V		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	514					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
RYR1	6261	broad.mit.edu	37	19	38993522	38993522	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38993522A>G	uc002oit.2	+	49	7968	c.7838A>G	c.(7837-7839)TAC>TGC	p.Y2613C	RYR1_uc002oiu.2_Missense_Mutation_p.Y2613C|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2613	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
ACTN4	81	broad.mit.edu	37	19	39200985	39200985	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39200985A>G	uc002oja.1	+						ACTN4_uc010egc.1_Intron	NM_004924	NP_004915			actinin, alpha 4						platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
SIRT2	22933	broad.mit.edu	37	19	39380364	39380364	+	Missense_Mutation	SNP	C	T	T	rs150309258	byFrequency;by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39380364C>T	uc002ojt.1	-	7	597	c.397G>A	c.(397-399)GCC>ACC	p.A133T	SIRT2_uc010egh.1_Missense_Mutation_p.A96T|SIRT2_uc010egi.1_Missense_Mutation_p.A96T|SIRT2_uc002ojs.1_Missense_Mutation_p.A113T|SIRT2_uc002oju.1_Missense_Mutation_p.A96T|SIRT2_uc010egj.1_Missense_Mutation_p.A96T|SIRT2_uc002ojv.1_Missense_Mutation_p.A131T	NM_012237	NP_036369	Q8IXJ6	SIRT2_HUMAN	sirtuin 2 isoform 1	133	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)															---	---	---	---
SARS2	54938	broad.mit.edu	37	19	39412061	39412061	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39412061C>T	uc002oka.2	-	5	720	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	SARS2_uc002ojz.2_5'UTR|SARS2_uc010xup.1_Missense_Mutation_p.R189Q|SARS2_uc002okb.2_Missense_Mutation_p.R187Q|SARS2_uc010xuq.1_Missense_Mutation_p.R187Q|SARS2_uc010xur.1_RNA	NM_017827	NP_060297	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2 isoform b precursor	187					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)															---	---	---	---
PAPL	390928	broad.mit.edu	37	19	39589225	39589225	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39589225C>T	uc002oki.2	+	3	523	c.249C>T	c.(247-249)GAC>GAT	p.D83D	PAPL_uc010egl.2_Silent_p.D83D	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	83						extracellular region	acid phosphatase activity|metal ion binding				0																		---	---	---	---
IL28A	282616	broad.mit.edu	37	19	39759494	39759494	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39759494C>T	uc002oku.1	+	2	240	c.188C>T	c.(187-189)GCC>GTC	p.A63V		NM_172138	NP_742150	Q8IZJ0	IL28A_HUMAN	interleukin 28A precursor	63					response to virus	extracellular space	cytokine activity			ovary(1)|skin(1)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;5.39e-26)|all cancers(26;4.1e-23)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)															---	---	---	---
PAF1	54623	broad.mit.edu	37	19	39879431	39879431	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39879431C>T	uc002old.2	-	9	886	c.711G>A	c.(709-711)GCG>GCA	p.A237A	PAF1_uc002ole.1_Silent_p.A227A|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	237					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)															---	---	---	---
MAP3K10	4294	broad.mit.edu	37	19	40698259	40698259	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40698259G>T	uc002ona.2	+	1	609	c.321G>T	c.(319-321)GGG>GGT	p.G107G		NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	107	Protein kinase.|ATP (By similarity).		G -> E (in a metastatic melanoma sample; somatic mutation).		activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity	p.G107E(1)		ovary(2)|lung(2)|skin(1)|pancreas(1)	6																		---	---	---	---
MAP3K10	4294	broad.mit.edu	37	19	40712065	40712065	+	Splice_Site	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40712065G>A	uc002ona.2	+	5	1723	c.1435_splice	c.e5+1	p.G479_splice	MAP3K10_uc002onb.2_Intron	NM_002446	NP_002437			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6																		---	---	---	---
MAP3K10	4294	broad.mit.edu	37	19	40721046	40721046	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40721046C>T	uc002ona.2	+	10	3000	c.2712C>T	c.(2710-2712)TTC>TTT	p.F904F	MAP3K10_uc002onb.2_Silent_p.F293F	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	904					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6																		---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41003397	41003397	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41003397C>T	uc002ony.2	+	7	756	c.670C>T	c.(670-672)CCT>TCT	p.P224S	SPTBN4_uc002onx.2_Missense_Mutation_p.P224S|SPTBN4_uc002onz.2_Missense_Mutation_p.P224S	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	224	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41009954	41009954	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41009954G>A	uc002ony.2	+	12	1666	c.1580G>A	c.(1579-1581)CGG>CAG	p.R527Q	SPTBN4_uc002onx.2_Missense_Mutation_p.R527Q|SPTBN4_uc002onz.2_Missense_Mutation_p.R527Q	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	527	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
LTBP4	8425	broad.mit.edu	37	19	41125264	41125264	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41125264G>A	uc002ooh.1	+	26	3284	c.3284G>A	c.(3283-3285)TGT>TAT	p.C1095Y	LTBP4_uc002oog.1_Missense_Mutation_p.C1058Y|LTBP4_uc002ooi.1_Missense_Mutation_p.C1028Y|LTBP4_uc002ooj.1_Translation_Start_Site|LTBP4_uc002ook.1_Missense_Mutation_p.C229Y|LTBP4_uc002ool.1_Missense_Mutation_p.C107Y|LTBP4_uc002oom.1_RNA|LTBP4_uc010xvp.1_Translation_Start_Site	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1095	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
LTBP4	8425	broad.mit.edu	37	19	41125313	41125313	+	Silent	SNP	A	G	G	rs35731433		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41125313A>G	uc002ooh.1	+	26	3333	c.3333A>G	c.(3331-3333)GAA>GAG	p.E1111E	LTBP4_uc002oog.1_Silent_p.E1074E|LTBP4_uc002ooi.1_Silent_p.E1044E|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Silent_p.E245E|LTBP4_uc002ool.1_Silent_p.E123E|LTBP4_uc002oom.1_RNA|LTBP4_uc010xvp.1_5'UTR	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1111	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
LTBP4	8425	broad.mit.edu	37	19	41135314	41135314	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41135314T>C	uc002ooh.1	+	34	4734	c.4734T>C	c.(4732-4734)TGT>TGC	p.C1578C	LTBP4_uc002oog.1_Silent_p.C1541C|LTBP4_uc002ooi.1_Silent_p.C1511C|LTBP4_uc002ooj.1_Silent_p.C451C|LTBP4_uc002ool.1_Silent_p.C590C|LTBP4_uc010xvp.1_Silent_p.C338C	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1578	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
ADCK4	79934	broad.mit.edu	37	19	41208606	41208606	+	Intron	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41208606G>T	uc002oor.2	-						ADCK4_uc002oop.1_5'Flank|ADCK4_uc002ooq.1_Intron	NM_024876	NP_079152			aarF domain containing kinase 4 isoform a							integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)													OREG0025476	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CYP2A6	1548	broad.mit.edu	37	19	41354549	41354549	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41354549A>G	uc002opl.3	-	3	484	c.463T>C	c.(463-465)TTC>CTC	p.F155L	CYP2A6_uc010ehe.1_5'UTR|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	155					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)													---	---	---	---
CYP2A7	1549	broad.mit.edu	37	19	41386114	41386114	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41386114T>C	uc002opm.2	-	4	1071	c.529A>G	c.(529-531)ACA>GCA	p.T177A	CYP2A7_uc002opo.2_Missense_Mutation_p.T177A|CYP2A7_uc002opn.2_Missense_Mutation_p.T126A	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	177						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)															---	---	---	---
CYP2F1	1572	broad.mit.edu	37	19	41622091	41622091	+	5'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41622091A>G	uc002opu.1	+	2					CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_5'UTR|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765			cytochrome P450, family 2, subfamily F,						naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0																		---	---	---	---
CYP2S1	29785	broad.mit.edu	37	19	41712580	41712580	+	3'UTR	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41712580C>A	uc002opw.2	+	9					CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_3'UTR	NM_030622	NP_085125			cytochrome P450, family 2, subfamily S,						xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1																		---	---	---	---
AXL	558	broad.mit.edu	37	19	41744382	41744382	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41744382G>T	uc010ehj.2	+	8	1192	c.1002G>T	c.(1000-1002)CTG>CTT	p.L334L	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehi.1_Silent_p.L334L|AXL_uc010ehk.2_Silent_p.L334L	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	334	Extracellular (Potential).|Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13																		---	---	---	---
CEACAM7	1087	broad.mit.edu	37	19	42191122	42191122	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42191122T>C	uc002ori.1	-	2	97	c.95A>G	c.(94-96)AAC>AGC	p.N32S	CEACAM7_uc010ehx.2_Missense_Mutation_p.N32S|CEACAM7_uc010ehy.1_Missense_Mutation_p.N32S	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	32						anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)														---	---	---	---
CEACAM3	1084	broad.mit.edu	37	19	42301579	42301579	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42301579G>A	uc002orn.1	+	2	199	c.123G>A	c.(121-123)ATG>ATA	p.M41I	CEACAM3_uc010eia.1_Missense_Mutation_p.M41I|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	41	Ig-like V-type.|Extracellular (Potential).					integral to membrane				skin(1)	1																		---	---	---	---
CD79A	973	broad.mit.edu	37	19	42383168	42383168	+	Missense_Mutation	SNP	A	G	G	rs151224661	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42383168A>G	uc002orv.2	+	2	373	c.188A>G	c.(187-189)AAC>AGC	p.N63S	CD79A_uc002oru.2_Missense_Mutation_p.N63S	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor	63	Ig-like C2-type.|Extracellular (Potential).				B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3								O|S		DLBCL								---	---	---	---
ARHGEF1	9138	broad.mit.edu	37	19	42408270	42408270	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42408270C>T	uc002orx.2	+						ARHGEF1_uc002ory.2_Intron|ARHGEF1_uc002orz.2_Intron|ARHGEF1_uc002osa.2_Intron|ARHGEF1_uc002osb.2_Intron|ARHGEF1_uc002osc.2_Intron|ARHGEF1_uc002osd.2_Intron|ARHGEF1_uc002ose.2_Intron	NM_004706	NP_004697			Rho guanine nucleotide exchange factor 1 isoform						cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)														---	---	---	---
RABAC1	10567	broad.mit.edu	37	19	42463428	42463428	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42463428T>C	uc002osf.2	-	1	101	c.17A>G	c.(16-18)GAC>GGC	p.D6G		NM_006423	NP_006414	Q9UI14	PRAF1_HUMAN	Rab acceptor 1	6	Cytoplasmic (By similarity).					cell junction|Golgi apparatus|integral to membrane|synaptic vesicle	identical protein binding				0																		---	---	---	---
ATP1A3	478	broad.mit.edu	37	19	42474390	42474390	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42474390C>T	uc002osg.2	-	18	2643	c.2489G>A	c.(2488-2490)CGG>CAG	p.R830Q	ATP1A3_uc010xwf.1_Missense_Mutation_p.R841Q|ATP1A3_uc010xwg.1_Missense_Mutation_p.R800Q|ATP1A3_uc010xwh.1_Missense_Mutation_p.R843Q|ATP1A3_uc002osh.2_Missense_Mutation_p.R830Q	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	830	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
ATP1A3	478	broad.mit.edu	37	19	42480695	42480695	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42480695T>C	uc002osg.2	-	15	2121	c.1967A>G	c.(1966-1968)CAC>CGC	p.H656R	ATP1A3_uc010xwf.1_Missense_Mutation_p.H667R|ATP1A3_uc010xwg.1_Missense_Mutation_p.H626R|ATP1A3_uc010xwh.1_Missense_Mutation_p.H669R|ATP1A3_uc002osh.2_Missense_Mutation_p.H656R	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	656	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
GRIK5	2901	broad.mit.edu	37	19	42507556	42507556	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42507556G>A	uc002osj.1	-	18	2477	c.2442C>T	c.(2440-2442)GGC>GGT	p.G814G	GRIK5_uc002osi.1_Silent_p.G386G	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	814	Helical; (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)													---	---	---	---
ZNF574	64763	broad.mit.edu	37	19	42583295	42583295	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42583295G>A	uc002osm.3	+	2	706	c.537G>A	c.(535-537)GTG>GTA	p.V179V	ZNF574_uc002osk.3_Silent_p.V269V	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)																---	---	---	---
ZNF526	116115	broad.mit.edu	37	19	42729973	42729973	+	Missense_Mutation	SNP	G	A	A	rs149858475		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42729973G>A	uc002osz.1	+	3	1574	c.1418G>A	c.(1417-1419)CGC>CAC	p.R473H		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	473	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)																---	---	---	---
ERF	2077	broad.mit.edu	37	19	42753338	42753338	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42753338T>C	uc002ote.3	-	4	1084	c.926A>G	c.(925-927)GAC>GGC	p.D309G	ERF_uc002otd.3_Missense_Mutation_p.D40G	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	309					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)																---	---	---	---
CIC	23152	broad.mit.edu	37	19	42791321	42791321	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42791321G>A	uc002otf.1	+	3	421	c.381G>A	c.(379-381)ACG>ACA	p.T127T		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	127	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)						T	DUX4	soft tissue sarcoma								---	---	---	---
LIPE	3991	broad.mit.edu	37	19	42911584	42911584	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42911584C>T	uc002otr.2	-	6	2156	c.1879G>A	c.(1879-1881)GGC>AGC	p.G627S	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	627					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)																---	---	---	---
CEACAM1	634	broad.mit.edu	37	19	43023277	43023277	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43023277T>G	uc002otv.2	-	5	1182	c.1069A>C	c.(1069-1071)ATC>CTC	p.I357L	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|CEACAM1_uc010eii.2_Intron|CEACAM1_uc002otw.2_Missense_Mutation_p.I357L|CEACAM1_uc010eij.2_Missense_Mutation_p.I357L|CEACAM1_uc002otx.2_Intron|CEACAM1_uc002oty.2_Intron|CEACAM1_uc002otz.2_Intron|CEACAM1_uc010eik.2_Intron|CEACAM1_uc002oua.2_Missense_Mutation_p.I357L|CEACAM1_uc002oub.2_Intron	NM_001712	NP_001703	P13688	CEAM1_HUMAN	carcinoembryonic antigen-related cell adhesion	357	Ig-like C2-type 3.|Extracellular (Potential).				angiogenesis|cell migration|homophilic cell adhesion|integrin-mediated signaling pathway	extracellular region|integral to plasma membrane|membrane fraction				ovary(1)|central_nervous_system(1)	2		Prostate(69;0.00682)		GBM - Glioblastoma multiforme(486;0.00148)	Arcitumomab(DB00113)													---	---	---	---
PSG5	5673	broad.mit.edu	37	19	43680308	43680308	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43680308G>A	uc002ovu.2	-						PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Intron|PSG5_uc002ovv.2_Intron|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772			pregnancy specific beta-1-glycoprotein 5						female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)																---	---	---	---
CADM4	199731	broad.mit.edu	37	19	44128256	44128256	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44128256T>C	uc002oxc.1	-							NM_145296	NP_660339			cell adhesion molecule 4 precursor						cell adhesion	integral to membrane					0		Prostate(69;0.0199)																---	---	---	---
LYPD5	284348	broad.mit.edu	37	19	44301943	44301943	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44301943G>A	uc002oxm.3	-	5	637	c.556C>T	c.(556-558)CGG>TGG	p.R186W	LYPD5_uc002oxn.3_Missense_Mutation_p.R143W	NM_001031749	NP_001026919	Q6UWN5	LYPD5_HUMAN	LY6/PLAUR domain containing 5 isoform A	186	UPAR/Ly6.					anchored to membrane|plasma membrane					0		Prostate(69;0.0352)																---	---	---	---
ZNF45	7596	broad.mit.edu	37	19	44418119	44418119	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44418119T>C	uc002oxu.1	-	4	1568	c.1469A>G	c.(1468-1470)CAC>CGC	p.H490R	ZNF45_uc002oxw.1_Missense_Mutation_p.H490R|ZNF45_uc002oxv.1_Missense_Mutation_p.H490R	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	490	C2H2-type 12.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
ZNF230	7773	broad.mit.edu	37	19	44514742	44514742	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44514742G>A	uc002oyb.1	+	5	802	c.551G>A	c.(550-552)CGT>CAT	p.R184H		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	184	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)																---	---	---	---
ZNF225	7768	broad.mit.edu	37	19	44635769	44635769	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44635769T>C	uc002oyj.1	+	5	1245	c.1002T>C	c.(1000-1002)CAT>CAC	p.H334H	ZNF225_uc010eje.1_Silent_p.H251H|ZNF225_uc010ejf.1_Silent_p.H334H	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	334	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)																---	---	---	---
ZNF226	7769	broad.mit.edu	37	19	44676371	44676371	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44676371A>G	uc002oyp.2	+						ZNF226_uc002oyn.2_Intron|ZNF226_uc002oyo.2_Intron|ZNF226_uc002oyq.2_Intron|ZNF226_uc002oyr.2_Intron|ZNF226_uc010ejg.2_Intron|ZNF226_uc002oys.2_Intron|ZNF226_uc002oyt.2_Intron	NM_001032373	NP_001027545			zinc finger protein 226 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)																---	---	---	---
ZNF180	7733	broad.mit.edu	37	19	44980768	44980768	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44980768A>G	uc002ozf.3	-	5	2212	c.1930T>C	c.(1930-1932)TTG>CTG	p.L644L	ZNF180_uc002ozh.3_Silent_p.L301L|ZNF180_uc002ozi.3_Silent_p.L617L|ZNF180_uc002ozg.3_Silent_p.L643L|ZNF180_uc010ejm.2_Silent_p.L619L	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	644	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)																---	---	---	---
BCL3	602	broad.mit.edu	37	19	45254502	45254502	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45254502A>G	uc010xxe.1	+	2	345	c.275A>G	c.(274-276)TAC>TGC	p.Y92C		NM_005178	NP_005169	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	92	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			ovary(1)|lung(1)	2	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)						T	IGH@	CLL 								---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45315633	45315633	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45315633C>T	uc002ozu.2	+	3	462	c.418C>T	c.(418-420)CGG>TGG	p.R140W	BCAM_uc002ozt.1_Missense_Mutation_p.R140W	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	140	Extracellular (Potential).|Ig-like V-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
ERCC2	2068	broad.mit.edu	37	19	45867349	45867349	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45867349G>A	uc002pbj.2	-	10	891	c.844C>T	c.(844-846)CGG>TGG	p.R282W	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.R204W|ERCC2_uc002pbk.2_Missense_Mutation_p.R258W|ERCC2_uc002pbl.3_Missense_Mutation_p.R258W|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	282	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)				Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
CD3EAP	10849	broad.mit.edu	37	19	45911617	45911617	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45911617C>T	uc002pbq.1	+	3	879	c.391C>T	c.(391-393)CAG>TAG	p.Q131*	PPP1R13L_uc002pbo.2_5'Flank|PPP1R13L_uc002pbp.2_5'Flank|CD3EAP_uc002pbr.1_Nonsense_Mutation_p.Q133*	NM_012099	NP_036231	O15446	RPA34_HUMAN	CD3E antigen, epsilon polypeptide associated	131					rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			large_intestine(2)|ovary(2)	4		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)														---	---	---	---
RTN2	6253	broad.mit.edu	37	19	45997462	45997462	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45997462G>A	uc002pcb.2	-	4	1004	c.776C>T	c.(775-777)ACG>ATG	p.T259M	RTN2_uc002pcc.2_Missense_Mutation_p.T259M|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	259						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)														---	---	---	---
SYMPK	8189	broad.mit.edu	37	19	46357726	46357726	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46357726T>C	uc002pdn.2	-	2	273	c.28A>G	c.(28-30)ACC>GCC	p.T10A	SYMPK_uc002pdo.1_Missense_Mutation_p.T10A|SYMPK_uc002pdp.1_Missense_Mutation_p.T10A|SYMPK_uc002pdq.1_Missense_Mutation_p.T10A	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	10	Interaction with HSF1.				cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)														---	---	---	---
PPP5C	5536	broad.mit.edu	37	19	46886738	46886738	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46886738G>A	uc002pem.2	+						PPP5C_uc010xya.1_Intron|PPP5C_uc002pen.2_Intron|PPP5C_uc010xyb.1_Intron	NM_006247	NP_006238			protein phosphatase 5, catalytic subunit						mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)														---	---	---	---
CCDC8	83987	broad.mit.edu	37	19	46914891	46914891	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46914891C>T	uc002pep.2	-	1	2029	c.1177G>A	c.(1177-1179)GCG>ACG	p.A393T		NM_032040	NP_114429	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	393						plasma membrane				ovary(3)	3				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)														---	---	---	---
PNMAL1	55228	broad.mit.edu	37	19	46974297	46974297	+	5'UTR	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46974297C>T	uc002peq.3	-	2					PNMAL1_uc002per.3_5'UTR	NM_018215	NP_060685			PNMA-like 1 isoform a												0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)														---	---	---	---
AP2S1	1175	broad.mit.edu	37	19	47342048	47342048	+	Silent	SNP	G	A	A	rs143384246		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47342048G>A	uc002pft.1	-	4	456	c.276C>T	c.(274-276)AAC>AAT	p.N92N	AP2S1_uc002pfu.1_Silent_p.N54N	NM_004069	NP_004060	P53680	AP2S1_HUMAN	adaptor-related protein complex 2, sigma 1	92					axon guidance|clathrin coat assembly|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|regulation of endocytosis|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	protein transporter activity				0		all_cancers(25;1.24e-06)|all_epithelial(76;1.09e-05)|all_lung(116;0.00019)|Lung NSC(112;0.000601)|Ovarian(192;0.0221)|all_neural(266;0.0459)|Breast(70;0.128)		OV - Ovarian serous cystadenocarcinoma(262;3.86e-05)|all cancers(93;0.000107)|Epithelial(262;0.00325)|GBM - Glioblastoma multiforme(486;0.0336)														---	---	---	---
GRLF1	2909	broad.mit.edu	37	19	47424757	47424757	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47424757T>C	uc010ekv.2	+	1	2825	c.2825T>C	c.(2824-2826)GTG>GCG	p.V942A		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	942					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)														---	---	---	---
KPTN	11133	broad.mit.edu	37	19	47987271	47987271	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47987271C>T	uc002pgy.2	-	1	251	c.147G>A	c.(145-147)AAG>AAA	p.K49K	KPTN_uc010xys.1_RNA|uc002pgz.1_5'Flank	NM_007059	NP_008990	Q9Y664	KPTN_HUMAN	kaptin (actin binding protein)	49					actin filament organization|cellular component movement|sensory perception of sound	actin cytoskeleton|growth cone|microtubule organizing center|nucleus|perinuclear region of cytoplasm|stereocilium	actin binding			ovary(1)	1		all_cancers(25;1.55e-10)|all_epithelial(76;3.4e-08)|all_lung(116;1.73e-07)|Lung NSC(112;3.95e-07)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		OV - Ovarian serous cystadenocarcinoma(262;0.000428)|all cancers(93;0.000631)|Epithelial(262;0.0153)|GBM - Glioblastoma multiforme(486;0.0694)												OREG0025593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PLA2G4C	8605	broad.mit.edu	37	19	48551593	48551593	+	3'UTR	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48551593G>T	uc002phx.2	-	17					PLA2G4C_uc002phv.2_RNA|PLA2G4C_uc002phw.2_3'UTR|PLA2G4C_uc010elr.2_3'UTR|PLA2G4C_uc010xzd.1_3'UTR	NM_003706	NP_003697			phospholipase A2, group IVC isoform 1 precursor						arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)														---	---	---	---
LIG1	3978	broad.mit.edu	37	19	48631219	48631219	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:48631219C>T	uc002pia.1	-	20	2000	c.1880G>A	c.(1879-1881)CGG>CAG	p.R627Q	LIG1_uc010xze.1_Missense_Mutation_p.R320Q|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.R559Q|LIG1_uc010xzg.1_Missense_Mutation_p.R596Q	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	627					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)								NER					---	---	---	---
FAM83E	54854	broad.mit.edu	37	19	49113254	49113254	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49113254C>T	uc002pjn.2	-	3	702	c.637G>A	c.(637-639)GTG>ATG	p.V213M		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	213										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)														---	---	---	---
RPL18	6141	broad.mit.edu	37	19	49119424	49119424	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49119424G>A	uc002pjq.1	-	5	366	c.333C>T	c.(331-333)AGC>AGT	p.S111S	FAM83E_uc002pjn.2_5'Flank|RPL18_uc002pjp.1_Silent_p.S59S|RPL18_uc010xzs.1_3'UTR	NM_000979	NP_000970	Q07020	RL18_HUMAN	ribosomal protein L18	111					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.89e-05)|all cancers(93;0.00011)|GBM - Glioblastoma multiforme(486;0.0061)|Epithelial(262;0.0154)														---	---	---	---
TULP2	7288	broad.mit.edu	37	19	49387117	49387117	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49387117T>C	uc002pkz.2	-							NM_003323	NP_003314			tubby like protein 2						visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)														---	---	---	---
TRPM4	54795	broad.mit.edu	37	19	49671550	49671550	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49671550G>A	uc002pmw.2	+	5	554	c.482G>A	c.(481-483)GGC>GAC	p.G161D	TRPM4_uc010emu.2_Missense_Mutation_p.G161D|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_5'UTR|TRPM4_uc010emv.2_Intron|TRPM4_uc010yal.1_Intron	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	161	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)														---	---	---	---
TEAD2	8463	broad.mit.edu	37	19	49850573	49850573	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49850573G>A	uc002pnj.2	-	9	874	c.783C>T	c.(781-783)CCC>CCT	p.P261P	TEAD2_uc002png.2_Silent_p.P264P|TEAD2_uc002pnh.2_Silent_p.P265P|TEAD2_uc002pni.2_Silent_p.P264P|TEAD2_uc010yao.1_Silent_p.P133P|TEAD2_uc010emw.2_Silent_p.P264P	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	261	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)														---	---	---	---
DKKL1	27120	broad.mit.edu	37	19	49868877	49868877	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49868877A>G	uc002pnk.2	+	3	509	c.295A>G	c.(295-297)ACC>GCC	p.T99A		NM_014419	NP_055234	Q9UK85	DKKL1_HUMAN	dickkopf-like 1 precursor	99					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity				0		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)														---	---	---	---
SLC17A7	57030	broad.mit.edu	37	19	49934038	49934038	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49934038A>G	uc002pnp.2	-	12	1593	c.1421T>C	c.(1420-1422)ATT>ACT	p.I474T	SLC17A7_uc002pno.2_Missense_Mutation_p.I136T	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	474	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)														---	---	---	---
ALDH16A1	126133	broad.mit.edu	37	19	49973652	49973652	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49973652C>T	uc002pnt.2	+	17	2453	c.2337C>T	c.(2335-2337)GCC>GCT	p.A779A	ALDH16A1_uc010yar.1_Silent_p.A728A|ALDH16A1_uc010yas.1_Silent_p.A614A|ALDH16A1_uc010yat.1_Silent_p.A616A	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	779							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)														---	---	---	---
RCN3	57333	broad.mit.edu	37	19	50031729	50031729	+	5'UTR	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50031729G>A	uc002poj.2	+	2						NM_020650	NP_065701			reticulocalbin 3, EF-hand calcium binding domain							endoplasmic reticulum lumen	calcium ion binding|protein binding			ovary(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)														---	---	---	---
MED25	81857	broad.mit.edu	37	19	50333092	50333092	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50333092G>A	uc002ppw.1	+	6	628	c.575G>A	c.(574-576)CGG>CAG	p.R192Q	MED25_uc010ybe.1_Intron|MED25_uc002ppx.1_5'UTR	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	192	Interaction with the Mediator complex.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)														---	---	---	---
PTOV1	53635	broad.mit.edu	37	19	50360220	50360220	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50360220C>T	uc002pqf.1	+						PTOV1_uc002ppz.3_Intron|PTOV1_uc002pqb.3_Intron|PTOV1_uc002pqa.2_Intron|PTOV1_uc002pqc.1_Intron|PTOV1_uc002pqd.2_Intron|PTOV1_uc002pqe.1_Intron	NM_017432	NP_059128			prostate tumor overexpressed 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)														---	---	---	---
ZNF473	25888	broad.mit.edu	37	19	50550263	50550263	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50550263T>C	uc002prn.2	+	5	2800	c.2563T>C	c.(2563-2565)TCG>CCG	p.S855P	ZNF473_uc002prm.2_Missense_Mutation_p.S855P|ZNF473_uc010ybo.1_Missense_Mutation_p.S843P	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	855	C2H2-type 20.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)												OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MYH14	79784	broad.mit.edu	37	19	50764738	50764738	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50764738G>A	uc002prr.1	+	19	2355	c.2308G>A	c.(2308-2310)GCG>ACG	p.A770T	MYH14_uc010enu.1_Missense_Mutation_p.A811T|MYH14_uc002prq.1_Missense_Mutation_p.A778T	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	770	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)														---	---	---	---
KCNC3	3748	broad.mit.edu	37	19	50826917	50826917	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50826917G>A	uc002pru.1	-	2	1588	c.1293C>T	c.(1291-1293)TTC>TTT	p.F431F	KCNC3_uc002prt.1_Silent_p.F67F	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	431	Helical; Voltage-sensor; Name=Segment S4; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)														---	---	---	---
NAPSA	9476	broad.mit.edu	37	19	50868804	50868804	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50868804T>C	uc002prx.2	-	1	128	c.75A>G	c.(73-75)ACA>ACG	p.T25T	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	25					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)														---	---	---	---
POLD1	5424	broad.mit.edu	37	19	50905562	50905562	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50905562C>T	uc002psb.3	+	6	746	c.690C>T	c.(688-690)GGC>GGT	p.G230G	POLD1_uc002psc.3_Silent_p.G230G|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Silent_p.G230G	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	230					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
POLD1	5424	broad.mit.edu	37	19	50921195	50921195	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50921195G>T	uc002psb.3	+	27	3371	c.3315G>T	c.(3313-3315)GAG>GAT	p.E1105D	POLD1_uc002psc.3_Missense_Mutation_p.E1105D|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.E1131D|SPIB_uc002psd.2_5'Flank|SPIB_uc002pse.2_5'Flank|SPIB_uc010ycc.1_5'Flank	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	1105					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
FAM71E1	112703	broad.mit.edu	37	19	50979589	50979589	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50979589T>C	uc002psh.2	-	1	415	c.57A>G	c.(55-57)TCA>TCG	p.S19S	FAM71E1_uc002psg.2_Silent_p.S19S|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	19										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)														---	---	---	---
C19orf63	284361	broad.mit.edu	37	19	50985397	50985397	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50985397C>T	uc002psl.2	+						C19orf63_uc002psj.2_Intron|C19orf63_uc002psk.2_Intron	NM_206538	NP_996261			hematopoietic signal peptide-containing isoform							extracellular region|integral to membrane					0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00733)|GBM - Glioblastoma multiforme(134;0.0252)														---	---	---	---
LRRC4B	94030	broad.mit.edu	37	19	51021967	51021967	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51021967T>C	uc002pss.2	-	3	1140	c.1003A>G	c.(1003-1005)ACG>GCG	p.T335A		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	335	LRRCT.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)														---	---	---	---
IGLON5	402665	broad.mit.edu	37	19	51825371	51825371	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51825371T>C	uc002pwc.2	+	2	133	c.133T>C	c.(133-135)TGT>CGT	p.C45R		NM_001101372	NP_001094842	A6NGN9	IGLO5_HUMAN	IgLON family member 5 precursor	45	Ig-like C2-type 1.					extracellular region					0																		---	---	---	---
SIGLEC8	27181	broad.mit.edu	37	19	51955734	51955734	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51955734C>G	uc002pwt.2	-	7	1466	c.1399G>C	c.(1399-1401)GAC>CAC	p.D467H	SIGLEC8_uc010yda.1_Missense_Mutation_p.D358H|SIGLEC8_uc002pwu.2_Intron|SIGLEC8_uc010eox.2_Missense_Mutation_p.D374H	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	467	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)														---	---	---	---
SIGLEC12	89858	broad.mit.edu	37	19	52002707	52002707	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52002707G>A	uc002pwx.1	-	3	1128	c.1072C>T	c.(1072-1074)CGA>TGA	p.R358*	SIGLEC12_uc002pww.1_Nonsense_Mutation_p.R240*|SIGLEC12_uc010eoy.1_Nonsense_Mutation_p.R85*	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	358	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)														---	---	---	---
FPR2	2358	broad.mit.edu	37	19	52272320	52272320	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52272320C>T	uc002pxr.2	+	2	454	c.409C>T	c.(409-411)CGC>TGC	p.R137C	FPR2_uc002pxs.3_Missense_Mutation_p.R137C|FPR2_uc010epf.2_Missense_Mutation_p.R137C	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	137	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4																		---	---	---	---
ZNF649	65251	broad.mit.edu	37	19	52394084	52394084	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52394084A>G	uc002pxy.2	-	5	1573	c.1305T>C	c.(1303-1305)TGT>TGC	p.C435C	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_Intron	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	435	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)														---	---	---	---
ZNF614	80110	broad.mit.edu	37	19	52519395	52519395	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52519395T>C	uc002pyj.2	-	5	1858	c.1456A>G	c.(1456-1458)ACC>GCC	p.T486A	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Missense_Mutation_p.T189A	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	486	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)														---	---	---	---
ZNF480	147657	broad.mit.edu	37	19	52817449	52817449	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52817449C>T	uc010ydl.1	+	3	186	c.116C>T	c.(115-117)GCG>GTG	p.A39V	ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Missense_Mutation_p.A39V|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)														---	---	---	---
ZNF480	147657	broad.mit.edu	37	19	52825579	52825579	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52825579T>C	uc010ydl.1	+	5	1146	c.1076T>C	c.(1075-1077)GTA>GCA	p.V359A	ZNF480_uc002pyv.2_Missense_Mutation_p.V282A|ZNF480_uc010ydm.1_Missense_Mutation_p.V316A|ZNF480_uc010epn.2_Missense_Mutation_p.V190A|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	359	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)														---	---	---	---
ZNF528	84436	broad.mit.edu	37	19	52918502	52918502	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52918502A>G	uc002pzh.2	+	7	823	c.397A>G	c.(397-399)AAG>GAG	p.K133E	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)														---	---	---	---
ZNF611	81856	broad.mit.edu	37	19	53208359	53208359	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53208359T>C	uc002pzz.2	-	7	2266	c.1949A>G	c.(1948-1950)TAC>TGC	p.Y650C	ZNF611_uc010eqc.2_Missense_Mutation_p.Y580C|ZNF611_uc010ydo.1_Missense_Mutation_p.Y580C|ZNF611_uc010ydr.1_Missense_Mutation_p.Y581C|ZNF611_uc010ydp.1_Missense_Mutation_p.Y650C|ZNF611_uc010ydq.1_Missense_Mutation_p.Y650C|ZNF611_uc002qaa.3_Missense_Mutation_p.Y580C	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	650	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)														---	---	---	---
ZNF160	90338	broad.mit.edu	37	19	53572886	53572886	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53572886T>C	uc010eqk.2	-	7	1317	c.901A>G	c.(901-903)ACT>GCT	p.T301A	ZNF160_uc002qaq.3_Missense_Mutation_p.T301A|ZNF160_uc002qar.3_Missense_Mutation_p.T301A	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	301	C2H2-type 2.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)														---	---	---	---
ZNF415	55786	broad.mit.edu	37	19	53612426	53612426	+	Missense_Mutation	SNP	C	T	T	rs138480197	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53612426C>T	uc002qax.2	-	7	1365	c.1016G>A	c.(1015-1017)CGG>CAG	p.R339Q	ZNF415_uc002qat.2_Missense_Mutation_p.R303Q|ZNF415_uc002qaw.2_Missense_Mutation_p.R291Q|ZNF415_uc010yds.1_Missense_Mutation_p.R291Q|ZNF415_uc010ydt.1_Missense_Mutation_p.R291Q|ZNF415_uc002qau.2_Missense_Mutation_p.R278Q|ZNF415_uc002qav.2_Missense_Mutation_p.R303Q|ZNF415_uc002qba.2_Missense_Mutation_p.R61Q|ZNF415_uc002qay.2_Missense_Mutation_p.R278Q|ZNF415_uc002qaz.2_Missense_Mutation_p.R339Q	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	339	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)														---	---	---	---
ZNF347	84671	broad.mit.edu	37	19	53643691	53643691	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53643691T>C	uc002qbb.1	-	5	2459	c.2390A>G	c.(2389-2391)AAA>AGA	p.K797R	ZNF347_uc010eql.1_Missense_Mutation_p.K798R|ZNF347_uc002qbc.1_Missense_Mutation_p.K798R	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	797	C2H2-type 20; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)														---	---	---	---
ZNF665	79788	broad.mit.edu	37	19	53669605	53669605	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53669605A>G	uc010eqm.1	-							NM_024733	NP_079009			zinc finger protein 665						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)														---	---	---	---
ZNF677	342926	broad.mit.edu	37	19	53741578	53741578	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53741578T>C	uc002qbf.1	-	5	587	c.402A>G	c.(400-402)CAA>CAG	p.Q134Q	ZNF677_uc002qbg.1_Silent_p.Q134Q	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	134					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)														---	---	---	---
VN1R2	317701	broad.mit.edu	37	19	53762245	53762245	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53762245C>A	uc002qbi.2	+	1	701	c.617C>A	c.(616-618)CCG>CAG	p.P206Q		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	206	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)														---	---	---	---
VN1R4	317703	broad.mit.edu	37	19	53770041	53770041	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53770041T>C	uc010ydu.1	-	1	878	c.878A>G	c.(877-879)TAC>TGC	p.Y293C		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	293	Cytoplasmic (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)											HNSCC(26;0.072)			---	---	---	---
ZNF761	388561	broad.mit.edu	37	19	53958506	53958506	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53958506A>G	uc010eqp.2	+	7	1203	c.745A>G	c.(745-747)AAG>GAG	p.K249E	ZNF761_uc010ydy.1_Missense_Mutation_p.K195E|ZNF761_uc002qbt.1_Missense_Mutation_p.K195E	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	249	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)														---	---	---	---
MIR498	574460	broad.mit.edu	37	19	54177496	54177496	+	RNA	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54177496G>T	hsa-mir-498|MI0003142	+			c.46G>T			MIR520E_hsa-mir-520e|MI0003143_5'Flank																	0																		---	---	---	---
MIR516B1	574490	broad.mit.edu	37	19	54240176	54240176	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54240176T>C	hsa-mir-516b-1|MI0003172	+			c.78T>C			MIR518A2_hsa-mir-518a-2|MI0003173_5'Flank																	0																		---	---	---	---
MYADM	91663	broad.mit.edu	37	19	54377168	54377168	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54377168T>C	uc002qcl.2	+	3	533	c.385T>C	c.(385-387)TCC>CCC	p.S129P	MYADM_uc002qcm.2_Missense_Mutation_p.S129P|MYADM_uc002qcn.2_Missense_Mutation_p.S129P|MYADM_uc002qco.2_Missense_Mutation_p.S129P|MYADM_uc002qcp.2_Missense_Mutation_p.S129P	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	129	MARVEL 1.					integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)														---	---	---	---
CNOT3	4849	broad.mit.edu	37	19	54656592	54656592	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54656592T>C	uc002qdj.1	+						CNOT3_uc010yel.1_Intron|CNOT3_uc002qdi.2_Intron|CNOT3_uc002qdk.1_Intron|CNOT3_uc010ere.1_Intron|CNOT3_uc002qdl.2_Intron	NM_014516	NP_055331			CCR4-NOT transcription complex, subunit 3						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
LILRB5	10990	broad.mit.edu	37	19	54754762	54754762	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54754762T>C	uc002qex.2	-	13	1772	c.1661A>G	c.(1660-1662)TAC>TGC	p.Y554C	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_3'UTR|LILRB5_uc002qey.2_Missense_Mutation_p.Y555C|LILRB5_uc002qez.2_Missense_Mutation_p.Y455C|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	554	ITIM motif 1.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
LENG8	114823	broad.mit.edu	37	19	54963842	54963842	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54963842G>A	uc002qfv.1	+	4	370	c.226G>A	c.(226-228)GCA>ACA	p.A76T	LENG8_uc002qfw.2_Missense_Mutation_p.A76T			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	76							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)														---	---	---	---
LENG8	114823	broad.mit.edu	37	19	54969703	54969703	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54969703A>G	uc002qfv.1	+	14	2276	c.2132A>G	c.(2131-2133)TAT>TGT	p.Y711C	LENG8_uc002qfw.2_Intron			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	711							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)														---	---	---	---
NLRP7	199713	broad.mit.edu	37	19	55451007	55451007	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55451007A>G	uc002qih.3	-	4	1256	c.1180T>C	c.(1180-1182)TTC>CTC	p.F394L	NLRP7_uc002qig.3_Missense_Mutation_p.F394L|NLRP7_uc002qii.3_Missense_Mutation_p.F394L|NLRP7_uc010esk.2_Missense_Mutation_p.F394L|NLRP7_uc010esl.2_Missense_Mutation_p.F422L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	394	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
NLRP2	55655	broad.mit.edu	37	19	55489171	55489171	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55489171G>A	uc002qij.2	+	4	463	c.377G>A	c.(376-378)CGC>CAC	p.R126H	NLRP2_uc010yfp.1_Missense_Mutation_p.R103H|NLRP2_uc010esn.2_Intron|NLRP2_uc010eso.2_Missense_Mutation_p.R126H|NLRP2_uc010esp.2_Missense_Mutation_p.R126H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	126					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)														---	---	---	---
PTPRH	5794	broad.mit.edu	37	19	55697344	55697344	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55697344A>G	uc002qjq.2	-	17	2860	c.2787T>C	c.(2785-2787)TGT>TGC	p.C929C	PTPRH_uc010esv.2_Silent_p.C751C	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	929	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)														---	---	---	---
SAPS1	22870	broad.mit.edu	37	19	55753611	55753611	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55753611G>A	uc002qjw.3	-	7	1010	c.768C>T	c.(766-768)TTC>TTT	p.F256F	SAPS1_uc002qjv.2_Silent_p.F318F	NM_014931	NP_055746	Q9UPN7	PP6R1_HUMAN	SAPS domain family, member 1	256	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding				0		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)														---	---	---	---
HSPBP1	23640	broad.mit.edu	37	19	55776758	55776758	+	Splice_Site	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55776758C>A	uc002qjx.2	-	6	1142	c.1032_splice	c.e6-1	p.S344_splice	HSPBP1_uc002qjy.2_Splice_Site_p.S298_splice|HSPBP1_uc002qkb.2_Intron|HSPBP1_uc002qka.2_Splice_Site_p.S298_splice|HSPBP1_uc002qkd.2_Splice_Site_p.S298_splice|HSPBP1_uc002qkc.2_Splice_Site_p.S298_splice|uc002qke.2_5'Flank	NM_012267	NP_036399			hsp70-interacting protein						positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)														---	---	---	---
UBE2S	27338	broad.mit.edu	37	19	55918226	55918226	+	Silent	SNP	G	A	A	rs139337996	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55918226G>A	uc002qkx.1	-	2	476	c.108C>T	c.(106-108)AAC>AAT	p.N36N	uc002qky.2_5'Flank	NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	36					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)														---	---	---	---
NLRP13	126204	broad.mit.edu	37	19	56413559	56413559	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56413559G>A	uc010ygg.1	-	9	2656	c.2631C>T	c.(2629-2631)TGC>TGT	p.C877C		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	877							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)														---	---	---	---
ZNF582	147948	broad.mit.edu	37	19	56896263	56896263	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56896263T>C	uc002qmz.1	-	5	682	c.523A>G	c.(523-525)AAA>GAA	p.K175E	ZNF582_uc002qmy.2_Missense_Mutation_p.K206E	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	175	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)														---	---	---	---
ZNF471	57573	broad.mit.edu	37	19	57036268	57036268	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57036268A>T	uc002qnh.2	+	5	965	c.832A>T	c.(832-834)ATT>TTT	p.I278F		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	278	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)														---	---	---	---
ZFP28	140612	broad.mit.edu	37	19	57065823	57065823	+	Missense_Mutation	SNP	G	A	A	rs142195358		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57065823G>A	uc002qnj.2	+	8	1740	c.1669G>A	c.(1669-1671)GGA>AGA	p.G557R	uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	557					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)														---	---	---	---
PEG3	5178	broad.mit.edu	37	19	57327050	57327050	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57327050G>A	uc002qnu.2	-	7	3111	c.2760C>T	c.(2758-2760)GGC>GGT	p.G920G	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.G891G|PEG3_uc002qnv.2_Silent_p.G920G|PEG3_uc002qnw.2_Silent_p.G796G|PEG3_uc002qnx.2_Silent_p.G794G|PEG3_uc010etr.2_Silent_p.G920G	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	920					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
PEG3	5178	broad.mit.edu	37	19	57330063	57330063	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57330063T>C	uc002qnu.2	-	5	1028	c.677A>G	c.(676-678)GAA>GGA	p.E226G	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.E101G|ZIM2_uc002qnq.2_Missense_Mutation_p.E101G|ZIM2_uc010etp.2_Missense_Mutation_p.E101G|ZIM2_uc010ygs.1_Missense_Mutation_p.E101G|PEG3_uc002qnt.2_Missense_Mutation_p.E227G|PEG3_uc002qnv.2_Missense_Mutation_p.E226G|PEG3_uc002qnw.2_Missense_Mutation_p.E101G|PEG3_uc002qnx.2_Missense_Mutation_p.E100G|PEG3_uc010etr.2_Missense_Mutation_p.E226G	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	226					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
PEG3	5178	broad.mit.edu	37	19	57334145	57334145	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57334145A>G	uc002qnu.2	-	3	892	c.541T>C	c.(541-543)TCC>CCC	p.S181P	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.S56P|ZIM2_uc002qnq.2_Missense_Mutation_p.S56P|ZIM2_uc010etp.2_Missense_Mutation_p.S56P|ZIM2_uc010ygs.1_Missense_Mutation_p.S56P|PEG3_uc002qnt.2_Missense_Mutation_p.S182P|PEG3_uc002qnv.2_Missense_Mutation_p.S181P|PEG3_uc002qnw.2_Missense_Mutation_p.S56P|PEG3_uc002qnx.2_Missense_Mutation_p.S55P|PEG3_uc010etr.2_Missense_Mutation_p.S181P	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	181					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
USP29	57663	broad.mit.edu	37	19	57641676	57641676	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57641676A>G	uc002qny.2	+	4	1989	c.1633A>G	c.(1633-1635)ACC>GCC	p.T545A		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	545					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF264	9422	broad.mit.edu	37	19	57705375	57705375	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57705375G>A	uc002qob.2	+							NM_003417	NP_003408			zinc finger protein 264						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)														---	---	---	---
ZNF264	9422	broad.mit.edu	37	19	57722986	57722986	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57722986A>G	uc002qob.2	+	4	934	c.521A>G	c.(520-522)GAG>GGG	p.E174G		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)														---	---	---	---
AURKC	6795	broad.mit.edu	37	19	57743127	57743127	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57743127A>G	uc002qoe.2	+	2	265	c.76A>G	c.(76-78)ACA>GCA	p.T26A	AURKC_uc002qoc.2_Missense_Mutation_p.T7A|AURKC_uc002qod.2_5'UTR|AURKC_uc010etv.2_Missense_Mutation_p.T23A	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	26					cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)														---	---	---	---
AURKC	6795	broad.mit.edu	37	19	57746724	57746724	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57746724A>T	uc002qoe.2	+	7	1058	c.869A>T	c.(868-870)CAC>CTC	p.H290L	AURKC_uc002qoc.2_Missense_Mutation_p.H271L|AURKC_uc002qod.2_Missense_Mutation_p.H256L|AURKC_uc010etv.2_Missense_Mutation_p.H287L	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	290	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)														---	---	---	---
ZNF543	125919	broad.mit.edu	37	19	57839139	57839139	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57839139A>G	uc002qoi.1	+	4	654	c.309A>G	c.(307-309)TTA>TTG	p.L103L		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)														---	---	---	---
ZNF543	125919	broad.mit.edu	37	19	57839764	57839764	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57839764G>A	uc002qoi.1	+	4	1279	c.934G>A	c.(934-936)GTG>ATG	p.V312M		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	312	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)														---	---	---	---
ZNF547	284306	broad.mit.edu	37	19	57879953	57879953	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57879953T>C	uc002qol.2	+						ZNF547_uc010ygx.1_Intron	NM_173631	NP_775902			zinc finger protein 547						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF548	147694	broad.mit.edu	37	19	57910856	57910856	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57910856T>A	uc002qom.2	+	3	1451	c.1201T>A	c.(1201-1203)TCA>ACA	p.S401T	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.S404T	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	401	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF17	7565	broad.mit.edu	37	19	57931169	57931169	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57931169C>T	uc002qoo.1	+	3	540	c.309C>T	c.(307-309)GAC>GAT	p.D103D	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.D105D	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)														---	---	---	---
ZNF749	388567	broad.mit.edu	37	19	57956392	57956392	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57956392A>G	uc002qoq.2	+	3	2130	c.1876A>G	c.(1876-1878)ACA>GCA	p.T626A	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	626	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)														---	---	---	---
ZNF416	55659	broad.mit.edu	37	19	58083888	58083888	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58083888C>T	uc002qpf.2	-	4	1555	c.1384G>A	c.(1384-1386)GCA>ACA	p.A462T	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)														---	---	---	---
ZNF211	10520	broad.mit.edu	37	19	58132782	58132782	+	5'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58132782A>G	uc010yhb.1	+	1					ZNF134_uc002qpo.2_3'UTR|ZNF134_uc002qpn.2_3'UTR	NM_198855	NP_942152			zinc finger protein 211 isoform 2							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF211	10520	broad.mit.edu	37	19	58152513	58152513	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58152513T>C	uc002qpq.2	+	3	839	c.659T>C	c.(658-660)GTG>GCG	p.V220A	ZNF211_uc010yhb.1_Missense_Mutation_p.V224A|ZNF211_uc002qpp.2_Missense_Mutation_p.V233A|ZNF211_uc002qpr.2_Missense_Mutation_p.V284A|ZNF211_uc002qps.2_Missense_Mutation_p.V285A|ZNF211_uc002qpt.2_Missense_Mutation_p.V232A|ZNF211_uc010yhc.1_Missense_Mutation_p.V232A|ZNF211_uc010yhd.1_Missense_Mutation_p.V159A|ZNF211_uc010yhe.1_Missense_Mutation_p.V211A	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	220						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)														---	---	---	---
ZNF671	79891	broad.mit.edu	37	19	58232449	58232449	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58232449G>A	uc002qpz.3	-	4	1104	c.1005C>T	c.(1003-1005)CAC>CAT	p.H335H	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Silent_p.H258H|ZNF671_uc010yhf.1_Silent_p.H237H	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	335	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)														---	---	---	---
ZNF587	84914	broad.mit.edu	37	19	58369951	58369951	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58369951G>A	uc002qql.2	+	3	309	c.171G>A	c.(169-171)TGG>TGA	p.W57*	ZNF587_uc002qqb.2_Nonsense_Mutation_p.W14*|ZNF587_uc010yhh.1_Nonsense_Mutation_p.W14*|ZNF587_uc002qqi.1_Nonsense_Mutation_p.W14*|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Nonsense_Mutation_p.W56*	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)														---	---	---	---
ZNF418	147686	broad.mit.edu	37	19	58439288	58439288	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58439288A>G	uc002qqs.1	-	4	553	c.261T>C	c.(259-261)TGT>TGC	p.C87C	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Silent_p.C2C	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	87	KRAB.|C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)														---	---	---	---
ZNF256	10172	broad.mit.edu	37	19	58453789	58453789	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58453789A>G	uc002qqu.2	-	3	622	c.387T>C	c.(385-387)TTT>TTC	p.F129F	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	129					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)														---	---	---	---
ZNF135	7694	broad.mit.edu	37	19	58579383	58579383	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58579383A>G	uc010yhq.1	+	5	1663	c.1567A>G	c.(1567-1569)AAA>GAA	p.K523E	ZNF135_uc002qre.2_Missense_Mutation_p.K511E|ZNF135_uc002qrd.1_Intron|ZNF135_uc002qrf.2_Missense_Mutation_p.K469E|ZNF135_uc002qrg.2_Missense_Mutation_p.K481E|ZNF135_uc010yhr.1_Missense_Mutation_p.K332E	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	523					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)														---	---	---	---
ZNF544	27300	broad.mit.edu	37	19	58773028	58773028	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58773028G>A	uc010euo.2	+	7	1530	c.1056G>A	c.(1054-1056)AAG>AAA	p.K352K	ZNF544_uc010yhw.1_RNA|ZNF544_uc010yhx.1_Silent_p.K324K|ZNF544_uc010yhy.1_Silent_p.K324K|ZNF544_uc002qrt.3_Silent_p.K210K|ZNF544_uc002qru.3_Silent_p.K210K|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)														---	---	---	---
A1BG	1	broad.mit.edu	37	19	58862876	58862876	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58862876A>G	uc002qsd.3	-	5	853	c.791T>C	c.(790-792)TTT>TCT	p.F264S	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	264	Ig-like V-type 3.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
A1BG	1	broad.mit.edu	37	19	58869006	58869006	+	RNA	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58869006C>T	uc002qsf.1	-	5		c.647G>A			ZNF497_uc002qsh.1_5'UTR|ZNF497_uc002qsi.1_5'UTR|uc002qsj.1_Missense_Mutation_p.A126V|uc002qsk.1_5'Flank					Homo sapiens primary hepatoblastoma mRNA for alpha-1-B glycoprotein precursor, partial cds, clone:HYST2477.							extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
ZNF324B	388569	broad.mit.edu	37	19	58967261	58967261	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58967261T>C	uc002qsv.1	+	4	1057	c.950T>C	c.(949-951)GTG>GCG	p.V317A	ZNF324B_uc002qsu.1_Missense_Mutation_p.V307A|ZNF324B_uc010euq.1_Missense_Mutation_p.V317A	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	317	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZNF446	55663	broad.mit.edu	37	19	58988663	58988663	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58988663C>A	uc002qsz.2	+	2	195	c.78C>A	c.(76-78)CGC>CGA	p.R26R	ZNF446_uc002qta.2_Silent_p.R26R|ZNF446_uc010eur.2_Silent_p.R26R	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	26	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZNF446	55663	broad.mit.edu	37	19	58989496	58989496	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58989496A>G	uc002qsz.2	+	4	692	c.575A>G	c.(574-576)AAC>AGC	p.N192S	ZNF446_uc002qta.2_Missense_Mutation_p.N192S|ZNF446_uc010eur.2_Missense_Mutation_p.N192S	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	192					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
SLC27A5	10998	broad.mit.edu	37	19	59012015	59012015	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59012015T>A	uc002qtc.2	-	5	1351	c.1241A>T	c.(1240-1242)GAT>GTT	p.D414V	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	414	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)														---	---	---	---
TRIM28	10155	broad.mit.edu	37	19	59059476	59059476	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59059476C>T	uc002qtg.1	+	7	1319	c.1030C>T	c.(1030-1032)CAC>TAC	p.H344Y	TRIM28_uc010eut.1_Missense_Mutation_p.H262Y|TRIM28_uc002qth.1_5'Flank	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	344	RBCC domain.|Leucine zipper alpha helical coiled-coil region.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)														---	---	---	---
MZF1	7593	broad.mit.edu	37	19	59073626	59073626	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:59073626C>T	uc002qto.2	-	6	2579	c.2018G>A	c.(2017-2019)CGC>CAC	p.R673H	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.R673H	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	673	C2H2-type 11.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)														---	---	---	---
RBCK1	10616	broad.mit.edu	37	20	409723	409723	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:409723A>G	uc002wdp.3	+	11	2130	c.1437A>G	c.(1435-1437)CCA>CCG	p.P479P	RBCK1_uc002wdq.3_Silent_p.P437P|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Silent_p.P309P	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	479					interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)																---	---	---	---
CSNK2A1	1457	broad.mit.edu	37	20	472935	472935	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:472935C>T	uc002wdw.1	-	9	977	c.584G>A	c.(583-585)CGA>CAA	p.R195Q	CSNK2A1_uc002wdx.1_Missense_Mutation_p.R195Q|CSNK2A1_uc002wdy.1_Missense_Mutation_p.R59Q	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	195	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)															---	---	---	---
C20orf46	55321	broad.mit.edu	37	20	1161734	1161734	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1161734T>C	uc010gaa.1	-	3	748	c.529A>G	c.(529-531)ATC>GTC	p.I177V	C20orf46_uc002weq.1_Missense_Mutation_p.I177V	NM_018354	NP_060824	Q9NUR3	CT046_HUMAN	hypothetical protein LOC55321	177	Helical; (Potential).					integral to membrane	protein binding			ovary(1)	1																		---	---	---	---
SIRPA	140885	broad.mit.edu	37	20	1915403	1915403	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1915403A>G	uc002wfq.2	+						SIRPA_uc010zps.1_Intron|SIRPA_uc002wfr.2_Intron|SIRPA_uc002wfs.2_Intron|SIRPA_uc002wft.2_Silent_p.V423V	NM_001040022	NP_001035111			signal-regulatory protein alpha precursor						blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)														---	---	---	---
TMC2	117532	broad.mit.edu	37	20	2593880	2593880	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2593880A>G	uc002wgf.1	+	14	1799	c.1784A>G	c.(1783-1785)TAC>TGC	p.Y595C	TMC2_uc002wgg.1_Missense_Mutation_p.Y579C|TMC2_uc010zpw.1_Missense_Mutation_p.Y427C|TMC2_uc010zpx.1_Missense_Mutation_p.Y426C	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	595	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3																		---	---	---	---
TMC2	117532	broad.mit.edu	37	20	2597830	2597830	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2597830G>A	uc002wgf.1	+	16	2068	c.2053G>A	c.(2053-2055)GTG>ATG	p.V685M	TMC2_uc002wgg.1_Missense_Mutation_p.V669M	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	685	Cytoplasmic (Potential).					integral to membrane				ovary(3)	3																		---	---	---	---
CPXM1	56265	broad.mit.edu	37	20	2778605	2778605	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2778605A>G	uc002wgu.2	-						CPXM1_uc010gas.2_Intron	NM_019609	NP_062555			carboxypeptidase X, member 1 precursor						cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4																		---	---	---	---
VPS16	64601	broad.mit.edu	37	20	2841438	2841438	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2841438C>T	uc002whe.2	+	6	607	c.559C>T	c.(559-561)CGA>TGA	p.R187*	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Nonsense_Mutation_p.R187*|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	187					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
VPS16	64601	broad.mit.edu	37	20	2845650	2845650	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2845650G>A	uc002whe.2	+	20	2001	c.1953G>A	c.(1951-1953)CTG>CTA	p.L651L	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'UTR|VPS16_uc002whf.2_Silent_p.L507L|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Silent_p.L337L|VPS16_uc002whi.2_Silent_p.L135L	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	651					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PTPRA	5786	broad.mit.edu	37	20	2998463	2998463	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2998463A>G	uc010zqd.1	+	12	1295	c.978A>G	c.(976-978)GGA>GGG	p.G326G	PTPRA_uc002whj.2_Silent_p.G315G|PTPRA_uc002whk.2_Silent_p.G306G|PTPRA_uc002whl.2_Silent_p.G306G|PTPRA_uc002whm.2_Silent_p.G82G|PTPRA_uc002whn.2_Silent_p.G306G|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	315	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
FASTKD5	60493	broad.mit.edu	37	20	3127441	3127441	+	Missense_Mutation	SNP	A	G	G	rs147125058	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3127441A>G	uc002whz.2	-	2	2587	c.2276T>C	c.(2275-2277)GTA>GCA	p.V759A	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	759					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0																		---	---	---	---
FASTKD5	60493	broad.mit.edu	37	20	3127511	3127511	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3127511A>G	uc002whz.2	-	2	2517	c.2206T>C	c.(2206-2208)TCC>CCC	p.S736P	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	736	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0																		---	---	---	---
C20orf194	25943	broad.mit.edu	37	20	3233240	3233240	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3233240T>C	uc002wii.2	-	37	3563	c.3512A>G	c.(3511-3513)GAC>GGC	p.D1171G	C20orf194_uc002wij.3_Missense_Mutation_p.D910G|C20orf194_uc002wik.2_Missense_Mutation_p.D845G	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	1171											0																		---	---	---	---
SLC23A2	9962	broad.mit.edu	37	20	4855324	4855324	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4855324T>C	uc002wlg.1	-	10	1218	c.843A>G	c.(841-843)TTA>TTG	p.L281L	SLC23A2_uc010zqr.1_Silent_p.L166L|SLC23A2_uc002wlh.1_Silent_p.L281L|SLC23A2_uc002wli.2_Silent_p.L280L	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	281	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2																		---	---	---	---
SLC23A2	9962	broad.mit.edu	37	20	4880213	4880213	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4880213G>A	uc002wlg.1	-	6	845	c.470C>T	c.(469-471)ACG>ATG	p.T157M	SLC23A2_uc010zqr.1_Missense_Mutation_p.T156M|SLC23A2_uc002wlh.1_Missense_Mutation_p.T157M|SLC23A2_uc002wli.2_Missense_Mutation_p.T156M	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	157	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2																		---	---	---	---
PCNA	5111	broad.mit.edu	37	20	5096170	5096170	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5096170A>G	uc002wlp.2	-	5	834	c.631T>C	c.(631-633)TAC>CAC	p.Y211H	C20orf30_uc010gbi.2_5'Flank|C20orf30_uc002wlk.2_5'Flank|C20orf30_uc002wll.2_5'Flank|C20orf30_uc002wlm.2_5'Flank|C20orf30_uc002wln.2_5'Flank|C20orf30_uc002wlo.2_5'Flank|PCNA_uc002wlq.2_Missense_Mutation_p.Y211H	NM_182649	NP_872590	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	211					cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			lung(1)	1													DNA_polymerases_(catalytic_subunits)					---	---	---	---
GPCPD1	56261	broad.mit.edu	37	20	5538579	5538579	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5538579A>G	uc002wme.3	-						GPCPD1_uc002wmd.3_Intron	NM_019593	NP_062539			hypothetical protein LOC56261						glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0																		---	---	---	---
MCM8	84515	broad.mit.edu	37	20	5948678	5948678	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5948678A>G	uc002wmi.2	+						MCM8_uc002wmj.2_Intron|MCM8_uc002wmk.2_Intron|MCM8_uc002wml.2_Intron|MCM8_uc010gbp.2_Intron|MCM8_uc002wmm.2_5'Flank	NM_032485	NP_115874			minichromosome maintenance complex component 8						cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1																		---	---	---	---
FERMT1	55612	broad.mit.edu	37	20	6057833	6057833	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:6057833C>A	uc002wmr.2	-	15	2810	c.2021G>T	c.(2020-2022)GGC>GTC	p.G674V	FERMT1_uc002wmq.2_Missense_Mutation_p.G227V|FERMT1_uc010gbt.2_Missense_Mutation_p.G417V	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	674					cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3																OREG0025763	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FERMT1	55612	broad.mit.edu	37	20	6057917	6057917	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:6057917T>C	uc002wmr.2	-	15	2726	c.1937A>G	c.(1936-1938)TAC>TGC	p.Y646C	FERMT1_uc002wmq.2_Missense_Mutation_p.Y199C|FERMT1_uc010gbt.2_Missense_Mutation_p.Y389C	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	646	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3																OREG0025763	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
BMP2	650	broad.mit.edu	37	20	6759620	6759620	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:6759620G>C	uc002wmu.1	+	3	1860	c.1075G>C	c.(1075-1077)GCA>CCA	p.A359P		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	359					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)													---	---	---	---
HAO1	54363	broad.mit.edu	37	20	7894828	7894828	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:7894828T>C	uc002wmw.1	-	3	552	c.528A>G	c.(526-528)AAA>AAG	p.K176K	HAO1_uc010gbu.2_Silent_p.K176K	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	176	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3																		---	---	---	---
SNAP25	6616	broad.mit.edu	37	20	10277662	10277662	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10277662G>A	uc002wnq.1	+	6	583	c.371G>A	c.(370-372)CGG>CAG	p.R124Q	SNAP25_uc002wnr.1_Missense_Mutation_p.R124Q|SNAP25_uc002wns.1_Missense_Mutation_p.R61Q|SNAP25_uc010gca.1_Missense_Mutation_p.R124Q|SNAP25_uc010gcb.1_Missense_Mutation_p.R61Q|SNAP25_uc010gcc.1_Intron	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	124					energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)													---	---	---	---
JAG1	182	broad.mit.edu	37	20	10624479	10624479	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10624479T>C	uc002wnw.2	-	20	2921	c.2405A>G	c.(2404-2406)AAC>AGC	p.N802S	JAG1_uc010gcd.1_Missense_Mutation_p.N360S	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	802	EGF-like 15; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9														Alagille_Syndrome				---	---	---	---
KIF16B	55614	broad.mit.edu	37	20	16348114	16348114	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:16348114G>A	uc002wpg.1	-						KIF16B_uc002wpe.1_Intron|KIF16B_uc002wpf.1_Intron|KIF16B_uc010gch.1_Intron|KIF16B_uc010gci.1_Missense_Mutation_p.R1286C	NM_024704	NP_078980			kinesin-like motor protein C20orf23						cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8																		---	---	---	---
KIF16B	55614	broad.mit.edu	37	20	16359926	16359926	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:16359926G>A	uc002wpg.1	-	19	2879	c.2721C>T	c.(2719-2721)CGC>CGT	p.R907R	KIF16B_uc002wpe.1_Silent_p.R289R|KIF16B_uc002wpf.1_Silent_p.R289R|KIF16B_uc010gch.1_Silent_p.R907R|KIF16B_uc010gci.1_Silent_p.R907R|KIF16B_uc010gcj.1_Silent_p.R918R	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	907	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8																		---	---	---	---
SNX5	27131	broad.mit.edu	37	20	17943357	17943357	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17943357T>C	uc002wqc.2	-						SNX5_uc002wqb.2_5'Flank|SNX5_uc002wqd.2_Intron|SNX5_uc002wqe.2_Intron|SNX5_uc010zrt.1_Intron|SNORD17_uc002wqf.1_RNA	NM_014426	NP_055241			sorting nexin 5						cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			large_intestine(1)	1																		---	---	---	---
ZNF133	7692	broad.mit.edu	37	20	18296188	18296188	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18296188T>C	uc010gcq.2	+	5	998	c.693T>C	c.(691-693)AGT>AGC	p.S231S	ZNF133_uc010zrv.1_Silent_p.S234S|ZNF133_uc010zrw.1_Silent_p.S168S|ZNF133_uc010gcr.2_Silent_p.S231S|ZNF133_uc010zrx.1_Silent_p.S136S|ZNF133_uc002wql.3_Silent_p.S230S|ZNF133_uc010gcs.2_Silent_p.S230S|ZNF133_uc010zry.1_Silent_p.S136S|ZNF133_uc002wqm.2_Silent_p.S231S	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	231	C2H2-type 1.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2																		---	---	---	---
POLR3F	10621	broad.mit.edu	37	20	18454108	18454108	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18454108C>A	uc002wqv.2	+						POLR3F_uc002wqw.2_Intron|POLR3F_uc002wqx.2_Intron	NM_006466	NP_006457			DNA-directed RNA polymerase III 39 kDa						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|protein binding				0																		---	---	---	---
SEC23B	10483	broad.mit.edu	37	20	18513351	18513351	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18513351T>C	uc002wqz.1	+	11	1720	c.1277T>C	c.(1276-1278)GTA>GCA	p.V426A	SEC23B_uc002wra.1_Missense_Mutation_p.V426A|SEC23B_uc002wrb.1_Missense_Mutation_p.V426A|SEC23B_uc010zsb.1_Missense_Mutation_p.V408A|SEC23B_uc002wrc.1_Missense_Mutation_p.V426A	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	426					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1																		---	---	---	---
SEC23B	10483	broad.mit.edu	37	20	18523751	18523751	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18523751T>C	uc002wqz.1	+	14	2043	c.1600T>C	c.(1600-1602)TTC>CTC	p.F534L	SEC23B_uc002wra.1_Missense_Mutation_p.F534L|SEC23B_uc002wrb.1_Missense_Mutation_p.F534L|SEC23B_uc010zsb.1_Missense_Mutation_p.F516L|SEC23B_uc002wrc.1_Missense_Mutation_p.F534L	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	534					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1																		---	---	---	---
CRNKL1	51340	broad.mit.edu	37	20	20020405	20020405	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20020405G>A	uc002wrs.2	-	12	1908	c.1876C>T	c.(1876-1878)CGG>TGG	p.R626W		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	626	HAT 12.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
C20orf26	26074	broad.mit.edu	37	20	20066187	20066187	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20066187T>C	uc002wru.2	+						C20orf26_uc010gcw.1_Intron|C20orf26_uc010zse.1_Intron|C20orf26_uc010zsf.1_Intron	NM_015585	NP_056400			hypothetical protein LOC26074											ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)														---	---	---	---
C20orf26	26074	broad.mit.edu	37	20	20144857	20144857	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20144857A>G	uc002wru.2	+	11	1266	c.1190A>G	c.(1189-1191)GAG>GGG	p.E397G	C20orf26_uc010gcw.1_Missense_Mutation_p.E351G|C20orf26_uc010zse.1_Missense_Mutation_p.E397G|C20orf26_uc010zsf.1_Missense_Mutation_p.E397G	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	397										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)														---	---	---	---
C20orf26	26074	broad.mit.edu	37	20	20226821	20226821	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20226821A>G	uc002wru.2	+	19	2197	c.2121A>G	c.(2119-2121)AAA>AAG	p.K707K	C20orf26_uc010zse.1_Silent_p.K687K|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Silent_p.K63K	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	707										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)														---	---	---	---
RALGAPA2	57186	broad.mit.edu	37	20	20571891	20571891	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20571891C>T	uc002wrz.2	-	17	2414	c.2271G>A	c.(2269-2271)CAG>CAA	p.Q757Q	RALGAPA2_uc010gcx.2_Silent_p.Q461Q|RALGAPA2_uc010zsg.1_Silent_p.Q205Q	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	757	Poly-Gln.				activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1																		---	---	---	---
RALGAPA2	57186	broad.mit.edu	37	20	20582381	20582381	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20582381C>T	uc002wrz.2	-	16	2291	c.2148G>A	c.(2146-2148)ACG>ACA	p.T716T	RALGAPA2_uc010gcx.2_Silent_p.T420T|RALGAPA2_uc010zsg.1_Silent_p.T117T	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	716					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1																		---	---	---	---
PLK1S1	55857	broad.mit.edu	37	20	21143065	21143065	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21143065T>C	uc002wsb.2	+	5	1092	c.959T>C	c.(958-960)GTC>GCC	p.V320A	PLK1S1_uc010zsh.1_Missense_Mutation_p.V217A|PLK1S1_uc010zsi.1_Missense_Mutation_p.V187A|PLK1S1_uc010zsj.1_RNA|uc002wsc.2_Intron|PLK1S1_uc002wsd.2_RNA	NM_018474	NP_060944	Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1 isoform 1	320					spindle organization	centrosome	protein kinase binding				0																		---	---	---	---
FOXA2	3170	broad.mit.edu	37	20	22563595	22563595	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:22563595G>A	uc002wsn.2	-	3	457	c.267C>T	c.(265-267)GGC>GGT	p.G89G	FOXA2_uc002wsm.2_Silent_p.G95G	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	89	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)																	---	---	---	---
NXT1	29107	broad.mit.edu	37	20	23334997	23334997	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:23334997C>T	uc002wsx.1	+	2	706	c.319C>T	c.(319-321)CGG>TGG	p.R107W		NM_013248	NP_037380	Q9UKK6	NXT1_HUMAN	NTF2-like export factor 1	107	NTF2.					cytoplasm|nuclear pore				ovary(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)																	---	---	---	---
ACSS1	84532	broad.mit.edu	37	20	25003605	25003605	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25003605A>G	uc002wub.2	-	5	1809	c.931T>C	c.(931-933)TAC>CAC	p.Y311H	ACSS1_uc002wuc.2_Missense_Mutation_p.Y311H|ACSS1_uc010gdc.2_Intron|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.Y228H	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	311					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
ABHD12	26090	broad.mit.edu	37	20	25290206	25290206	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:25290206C>T	uc002wus.1	-	7	763	c.625G>A	c.(625-627)GGT>AGT	p.G209S	ABHD12_uc002wuq.2_Missense_Mutation_p.G209S|ABHD12_uc002wur.2_Missense_Mutation_p.G209S|ABHD12_uc002wut.1_Missense_Mutation_p.G209S|ABHD12_uc002wuu.1_5'UTR	NM_001042472	NP_001035937	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform a	209	Extracellular (Potential).					integral to membrane	acylglycerol lipase activity			skin(1)	1																		---	---	---	---
MYLK2	85366	broad.mit.edu	37	20	30419795	30419795	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30419795C>T	uc002wwq.2	+						MYLK2_uc002wws.2_Intron|MYLK2_uc010gdw.1_Intron	NM_033118	NP_149109			skeletal myosin light chain kinase						cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)															---	---	---	---
HCK	3055	broad.mit.edu	37	20	30671779	30671779	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30671779C>T	uc002wxh.2	+	7	786	c.615C>T	c.(613-615)AAC>AAT	p.N205N	HCK_uc010gdy.2_Silent_p.N184N|HCK_uc002wxi.2_Silent_p.N183N	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	205	SH2.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
PLAGL2	5326	broad.mit.edu	37	20	30785129	30785129	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30785129A>G	uc002wxn.2	-	3	834	c.617T>C	c.(616-618)GTA>GCA	p.V206A		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	206	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
KIF3B	9371	broad.mit.edu	37	20	30898349	30898349	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30898349G>A	uc002wxq.2	+	2	936	c.769G>A	c.(769-771)GCA>ACA	p.A257T	KIF3B_uc010ztv.1_Missense_Mutation_p.A257T|KIF3B_uc010ztw.1_Missense_Mutation_p.A257T	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	257	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)															---	---	---	---
ASXL1	171023	broad.mit.edu	37	20	31022395	31022395	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31022395C>T	uc002wxs.2	+	12	2306	c.1880C>T	c.(1879-1881)GCG>GTG	p.A627V	ASXL1_uc010geb.2_Missense_Mutation_p.A518V	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	627					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.A627fs*7(2)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248								F|N|Mis		MDS|CMML								---	---	---	---
DNMT3B	1789	broad.mit.edu	37	20	31372648	31372648	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31372648C>T	uc002wyc.2	+	4	610	c.289C>T	c.(289-291)CGT>TGT	p.R97C	DNMT3B_uc010ztx.1_RNA|DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.R97C|DNMT3B_uc002wye.2_Missense_Mutation_p.R97C|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.R97C|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Missense_Mutation_p.R109C	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	97	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5																		---	---	---	---
SUN5	140732	broad.mit.edu	37	20	31577472	31577472	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31577472T>C	uc002wyi.2	-	9	660	c.567A>G	c.(565-567)ATA>ATG	p.I189M		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	189					spermatogenesis					skin(1)	1																		---	---	---	---
C20orf186	149954	broad.mit.edu	37	20	31672763	31672763	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31672763A>G	uc010zue.1	+	4	758	c.743A>G	c.(742-744)TAC>TGC	p.Y248C		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	248						cytoplasm|extracellular region	lipid binding				0																		---	---	---	---
CDK5RAP1	51654	broad.mit.edu	37	20	31946924	31946924	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31946924G>T	uc010gek.2	-	15	1855	c.1731C>A	c.(1729-1731)ACC>ACA	p.T577T	CDK5RAP1_uc002wyy.2_Silent_p.T473T|CDK5RAP1_uc002wyz.2_Silent_p.T563T|CDK5RAP1_uc002wza.2_Silent_p.T562T|CDK5RAP1_uc010gel.2_Silent_p.T472T|CDK5RAP1_uc010gem.2_Silent_p.T486T|CDK5RAP1_uc002wzc.1_3'UTR|CDK5RAP1_uc002wzb.1_3'UTR	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	577	CDK5R1-binding.|TRAM.				brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5																		---	---	---	---
SNTA1	6640	broad.mit.edu	37	20	32005722	32005722	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32005722A>G	uc002wzd.1	-	3	776	c.504T>C	c.(502-504)TAT>TAC	p.Y168Y	SNTA1_uc010zuf.1_Silent_p.Y168Y	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	168	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1																		---	---	---	---
NCOA6	23054	broad.mit.edu	37	20	33330967	33330967	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33330967T>C	uc002xav.2	-	12	5664	c.3093A>G	c.(3091-3093)CAA>CAG	p.Q1031Q	NCOA6_uc002xaw.2_Silent_p.Q1031Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1031	NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7																		---	---	---	---
EIF6	3692	broad.mit.edu	37	20	33872297	33872297	+	5'UTR	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33872297T>C	uc002xbv.1	-	1					EIF6_uc002xbx.1_Splice_Site|EIF6_uc002xbz.1_Splice_Site|EIF6_uc002xby.1_Splice_Site	NM_181468	NP_852133			eukaryotic translation initiation factor 6						mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)															---	---	---	---
FAM83C	128876	broad.mit.edu	37	20	33874637	33874637	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33874637G>A	uc010zux.1	-	4	2063	c.1945C>T	c.(1945-1947)CCT>TCT	p.P649S	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Missense_Mutation_p.P304S	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	649										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)															---	---	---	---
CEP250	11190	broad.mit.edu	37	20	34089803	34089803	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34089803T>C	uc002xcm.2	+						CEP250_uc010zve.1_Intron	NM_007186	NP_009117			centrosomal protein 2						centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)															---	---	---	---
ERGIC3	51614	broad.mit.edu	37	20	34145273	34145273	+	Nonstop_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34145273T>C	uc002xct.2	+	13	1219	c.1150T>C	c.(1150-1152)TAG>CAG	p.*384Q	ERGIC3_uc002xcs.2_Nonstop_Mutation_p.*389Q|ERGIC3_uc002xcu.2_Nonstop_Mutation_p.*399Q|ERGIC3_uc002xcv.2_Nonstop_Mutation_p.*347Q	NM_015966	NP_057050	Q9Y282	ERGI3_HUMAN	serologically defined breast cancer antigen 84	384					vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane	protein binding			large_intestine(2)|ovary(1)	3	Lung NSC(9;0.00489)|all_lung(11;0.00729)		BRCA - Breast invasive adenocarcinoma(18;0.0127)															---	---	---	---
PHF20	51230	broad.mit.edu	37	20	34526819	34526819	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34526819A>G	uc002xek.1	+	16	2612	c.2501A>G	c.(2500-2502)TAT>TGT	p.Y834C		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	834					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)																	---	---	---	---
C20orf152	140894	broad.mit.edu	37	20	34618478	34618478	+	3'UTR	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34618478A>G	uc002xes.1	+	11					C20orf152_uc002xer.1_Missense_Mutation_p.I543V|C20orf152_uc010gfp.1_RNA					SubName: Full=C20orf152 protein;												0	Breast(12;0.00631)																	---	---	---	---
EPB41L1	2036	broad.mit.edu	37	20	34773147	34773147	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34773147T>C	uc002xfb.2	+	7	846	c.675T>C	c.(673-675)GGT>GGC	p.G225G	EPB41L1_uc002xeu.2_Silent_p.G163G|EPB41L1_uc010zvo.1_Silent_p.G225G|EPB41L1_uc002xev.2_Silent_p.G225G|EPB41L1_uc002xew.2_Silent_p.G128G|EPB41L1_uc002xex.2_Silent_p.G194G|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Silent_p.G163G	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	225	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)																	---	---	---	---
DLGAP4	22839	broad.mit.edu	37	20	35060838	35060838	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35060838C>T	uc002xff.2	+	3	1153	c.718C>T	c.(718-720)CGC>TGC	p.R240C	DLGAP4_uc010zvp.1_Missense_Mutation_p.R240C	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	240					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)																---	---	---	---
DLGAP4	22839	broad.mit.edu	37	20	35125161	35125161	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35125161A>G	uc002xff.2	+	8	2137	c.1702A>G	c.(1702-1704)ACC>GCC	p.T568A	DLGAP4_uc010zvp.1_Missense_Mutation_p.T568A|DLGAP4_uc002xfg.2_5'UTR|DLGAP4_uc002xfh.2_Missense_Mutation_p.T29A|DLGAP4_uc002xfi.2_5'UTR|DLGAP4_uc002xfj.2_5'Flank	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	568					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)																---	---	---	---
SAMHD1	25939	broad.mit.edu	37	20	35559270	35559270	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35559270T>C	uc002xgh.1	-	5	648	c.518A>G	c.(517-519)TAT>TGT	p.Y173C		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	173	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)																---	---	---	---
RBL1	5933	broad.mit.edu	37	20	35661170	35661170	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35661170A>G	uc002xgi.2	-	16	2359	c.2280T>C	c.(2278-2280)GGT>GGC	p.G760G	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Silent_p.G760G	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	760	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)																---	---	---	---
RPN2	6185	broad.mit.edu	37	20	35828866	35828866	+	Intron	SNP	G	A	A	rs144494243	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35828866G>A	uc002xgp.2	+						RPN2_uc002xgo.3_Intron|RPN2_uc010gfw.2_Intron|RPN2_uc002xgq.2_Intron	NM_002951	NP_002942			ribophorin II isoform 1 precursor						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
GHRH	2691	broad.mit.edu	37	20	35882611	35882611	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35882611A>G	uc002xgr.2	-	3	308	c.308_splice	c.e3+1	p.S103_splice	GHRH_uc002xgs.2_Splice_Site_p.S103_splice|GHRH_uc002xgt.2_Splice_Site_p.R103_splice	NM_021081	NP_066567			growth hormone releasing hormone preproprotein						activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			ovary(1)	1		Myeloproliferative disorder(115;0.00878)																---	---	---	---
RPRD1B	58490	broad.mit.edu	37	20	36668870	36668870	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:36668870T>A	uc002xho.3	+	2	587	c.185T>A	c.(184-186)TTA>TAA	p.L62*		NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	62	CID.									pancreas(1)	1																		---	---	---	---
SLC32A1	140679	broad.mit.edu	37	20	37357038	37357038	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37357038T>G	uc002xjc.2	+	2	1597	c.1334T>G	c.(1333-1335)CTC>CGC	p.L445R		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	445	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)													---	---	---	---
PPP1R16B	26051	broad.mit.edu	37	20	37531369	37531369	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37531369G>A	uc002xje.2	+	6	819	c.630G>A	c.(628-630)GCG>GCA	p.A210A	PPP1R16B_uc010ggc.2_Silent_p.A210A	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	210					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
DHX35	60625	broad.mit.edu	37	20	37620999	37620999	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:37620999T>C	uc002xjh.2	+	7	524	c.513T>C	c.(511-513)AGT>AGC	p.S171S	DHX35_uc010zwa.1_Silent_p.S16S|DHX35_uc010zwb.1_Silent_p.S16S|DHX35_uc010zwc.1_Silent_p.S140S	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	171	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)																---	---	---	---
LPIN3	64900	broad.mit.edu	37	20	39976200	39976200	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39976200T>C	uc002xjx.2	+	3	292	c.201T>C	c.(199-201)ATT>ATC	p.I67I	LPIN3_uc010ggh.2_Silent_p.I67I|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	67	N-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)																---	---	---	---
EMILIN3	90187	broad.mit.edu	37	20	39990405	39990405	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39990405T>C	uc002xjy.1	-	4	2028	c.1804A>G	c.(1804-1806)AGT>GGT	p.S602G		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	602						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)																---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40044014	40044014	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40044014C>T	uc002xka.1	-	34	6929	c.6751G>A	c.(6751-6753)GCC>ACC	p.A2251T	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2251					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
PTPRT	11122	broad.mit.edu	37	20	40747089	40747089	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40747089T>C	uc002xkg.2	-	21	3120	c.2936A>G	c.(2935-2937)AAC>AGC	p.N979S	PTPRT_uc010ggj.2_Missense_Mutation_p.N998S|PTPRT_uc010ggi.2_Missense_Mutation_p.N182S	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	979	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)																---	---	---	---
L3MBTL	26013	broad.mit.edu	37	20	42169384	42169384	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42169384G>A	uc010zwh.1	+						L3MBTL_uc002xkl.2_Intron|L3MBTL_uc002xkm.2_Intron|L3MBTL_uc010ggl.2_Intron|L3MBTL_uc002xkn.1_Intron|L3MBTL_uc002xko.2_Intron|L3MBTL_uc002xkp.2_Intron|SGK2_uc002xkq.1_Intron	NM_015478	NP_056293			l(3)mbt-like isoform I						chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
L3MBTL	26013	broad.mit.edu	37	20	42169672	42169672	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42169672A>G	uc010zwh.1	+	22	2473	c.2427A>G	c.(2425-2427)GGA>GGG	p.G809G	L3MBTL_uc002xkl.2_Silent_p.G741G|L3MBTL_uc002xkm.2_3'UTR|L3MBTL_uc010ggl.2_3'UTR|L3MBTL_uc002xkn.1_Intron|L3MBTL_uc002xko.2_3'UTR|L3MBTL_uc002xkp.2_Silent_p.G129G|SGK2_uc002xkq.1_Intron	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	Error:Variant_position_missing_in_Q9Y468_after_alignment					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
SGK2	10110	broad.mit.edu	37	20	42203604	42203604	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42203604G>T	uc002xkv.2	+	9	1052	c.833G>T	c.(832-834)TGG>TTG	p.W278L	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.W218L|SGK2_uc010ggm.2_Missense_Mutation_p.W218L|SGK2_uc002xks.2_Missense_Mutation_p.W217L|SGK2_uc002xku.2_Missense_Mutation_p.W218L	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	278	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
MYBL2	4605	broad.mit.edu	37	20	42315583	42315583	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42315583G>A	uc002xlb.1	+	5	586	c.371G>A	c.(370-372)CGC>CAC	p.R124H	MYBL2_uc010zwj.1_Missense_Mutation_p.R100H|MYBL2_uc002xla.1_Missense_Mutation_p.R124H	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	124	H-T-H motif (By similarity).|HTH myb-type 2.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
GTSF1L	149699	broad.mit.edu	37	20	42355289	42355289	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:42355289G>A	uc002xld.2	-	1	354	c.46C>T	c.(46-48)CGA>TGA	p.R16*	GTSF1L_uc002xlc.2_Nonsense_Mutation_p.R16*	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	16	CHHC-type.						metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)															---	---	---	---
TTPAL	79183	broad.mit.edu	37	20	43109032	43109032	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43109032C>T	uc002xmc.1	+	3	517	c.393C>T	c.(391-393)ACC>ACT	p.T131T	TTPAL_uc002xmd.1_Silent_p.T131T|TTPAL_uc010ggr.1_Missense_Mutation_p.P9L	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	131	CRAL-TRIO.					intracellular	transporter activity			breast(1)	1																		---	---	---	---
ADA	100	broad.mit.edu	37	20	43257798	43257798	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43257798G>A	uc002xmj.2	-	3	236	c.108C>T	c.(106-108)ATC>ATT	p.I36I	ADA_uc010ggt.2_RNA	NM_000022	NP_000013	P00813	ADA_HUMAN	adenosine deaminase	36					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			pancreas(2)|ovary(1)	3		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)									Adenosine_Deaminase_Deficiency				---	---	---	---
SEMG1	6406	broad.mit.edu	37	20	43837338	43837338	+	3'UTR	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:43837338C>T	uc002xni.2	+	2					SEMG1_uc002xnj.2_3'UTR|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_3'UTR	NM_003007	NP_002998			semenogelin I preproprotein						insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ZNF335	63925	broad.mit.edu	37	20	44578447	44578447	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44578447C>T	uc002xqw.2	-	24	3784	c.3661G>A	c.(3661-3663)GAC>AAC	p.D1221N	ZNF335_uc002xqv.2_Missense_Mutation_p.D333N|ZNF335_uc010zxk.1_Missense_Mutation_p.D1066N	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1221	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)																---	---	---	---
SULF2	55959	broad.mit.edu	37	20	46295229	46295229	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46295229T>C	uc002xto.2	-	12	1910	c.1580A>G	c.(1579-1581)TAC>TGC	p.Y527C	SULF2_uc002xtr.2_Missense_Mutation_p.Y527C|SULF2_uc002xtq.2_Missense_Mutation_p.Y527C|SULF2_uc010zyd.1_5'Flank	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	527					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6																		---	---	---	---
SULF2	55959	broad.mit.edu	37	20	46311886	46311886	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:46311886C>T	uc002xto.2	-	7	1246	c.916G>A	c.(916-918)GAG>AAG	p.E306K	SULF2_uc002xtr.2_Missense_Mutation_p.E306K|SULF2_uc002xtq.2_Missense_Mutation_p.E306K	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	306					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6																		---	---	---	---
ZNFX1	57169	broad.mit.edu	37	20	47868143	47868143	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47868143T>G	uc002xui.2	-	13	3480	c.3233A>C	c.(3232-3234)GAA>GCA	p.E1078A		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1078							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
ZNFX1	57169	broad.mit.edu	37	20	47887946	47887946	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47887946T>C	uc002xui.2	-	3	650	c.403A>G	c.(403-405)ACA>GCA	p.T135A		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	135							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)															---	---	---	---
B4GALT5	9334	broad.mit.edu	37	20	48256242	48256242	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48256242C>T	uc002xuu.3	-	7	1084	c.890G>A	c.(889-891)GGT>GAT	p.G297D		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	297	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)															---	---	---	---
PTPN1	5770	broad.mit.edu	37	20	49184937	49184937	+	Silent	SNP	C	T	T	rs143550876	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49184937C>T	uc002xvl.2	+	4	450	c.276C>T	c.(274-276)TGC>TGT	p.C92C	PTPN1_uc010zys.1_Silent_p.C19C	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	92	Tyrosine-protein phosphatase.				blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)													---	---	---	---
FAM65C	140876	broad.mit.edu	37	20	49247292	49247292	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49247292T>C	uc002xvm.2	-	2	411	c.93A>G	c.(91-93)GCA>GCG	p.A31A	FAM65C_uc010zyt.1_Silent_p.A35A|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Silent_p.A31A	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	31										ovary(2)	2																		---	---	---	---
PARD6B	84612	broad.mit.edu	37	20	49366647	49366647	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49366647A>G	uc002xvo.2	+	3	984	c.741A>G	c.(739-741)AGA>AGG	p.R247R		NM_032521	NP_115910	Q9BYG5	PAR6B_HUMAN	PAR-6 beta	247	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				axonogenesis|cell cycle|cell division|establishment or maintenance of cell polarity|protein complex assembly|regulation of cell migration|tight junction assembly	cytosol|tight junction	protein binding			kidney(1)	1																		---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49509799	49509799	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49509799T>C	uc002xvt.1	-	5	1797	c.1452A>G	c.(1450-1452)ATA>ATG	p.I484M	ADNP_uc002xvu.1_Missense_Mutation_p.I484M	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	484						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
ADNP	23394	broad.mit.edu	37	20	49520468	49520468	+	Silent	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49520468T>A	uc002xvt.1	-	3	411	c.66A>T	c.(64-66)ATA>ATT	p.I22I	ADNP_uc002xvu.1_Silent_p.I22I	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	22						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
KCNG1	3755	broad.mit.edu	37	20	49626525	49626525	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:49626525G>A	uc002xwa.3	-	2	646	c.351C>T	c.(349-351)TTC>TTT	p.F117F	KCNG1_uc002xwb.2_Silent_p.F117F	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	117	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
NFATC2	4773	broad.mit.edu	37	20	50140511	50140511	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50140511T>C	uc002xwd.2	-	2	489	c.269A>G	c.(268-270)GAT>GGT	p.D90G	NFATC2_uc002xwc.2_Missense_Mutation_p.D90G|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Missense_Mutation_p.D70G|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Missense_Mutation_p.D70G	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	90					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)																	---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50705146	50705146	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50705146C>T	uc002xwk.2	-	8	1362	c.1013G>A	c.(1012-1014)TGC>TAC	p.C338Y	ZFP64_uc002xwj.2_Missense_Mutation_p.C119Y	NM_199427	NP_955459	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform d	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50803619	50803619	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50803619G>A	uc002xwl.2	-						ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Intron|ZFP64_uc002xwn.2_Intron	NM_018197	NP_060667			zinc finger protein 64 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
TSHZ2	128553	broad.mit.edu	37	20	51870983	51870983	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:51870983G>T	uc002xwo.2	+	2	1942	c.986G>T	c.(985-987)CGG>CTG	p.R329L		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	329					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)															---	---	---	---
ZNF217	7764	broad.mit.edu	37	20	52192756	52192756	+	Silent	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:52192756A>C	uc002xwq.3	-	3	2818	c.2547T>G	c.(2545-2547)CCT>CCG	p.P849P	ZNF217_uc010gij.1_Silent_p.P841P	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	849					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)															---	---	---	---
BMP7	655	broad.mit.edu	37	20	55758796	55758796	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55758796G>A	uc010gip.1	-	4	1469	c.940C>T	c.(940-942)CGG>TGG	p.R314W	BMP7_uc010giq.1_Intron|BMP7_uc002xyc.2_Missense_Mutation_p.R314W	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	314					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)															---	---	---	---
SPO11	23626	broad.mit.edu	37	20	55913380	55913380	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55913380T>C	uc002xye.2	+	9	886	c.793T>C	c.(793-795)TGG>CGG	p.W265R	SPO11_uc002xyf.2_Missense_Mutation_p.W227R	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	265					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)										Editing_and_processing_nucleases					---	---	---	---
GNAS	2778	broad.mit.edu	37	20	57485796	57485796	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57485796C>A	uc002xzw.2	+	13	3311	c.3026C>A	c.(3025-3027)GCT>GAT	p.A1009D	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.A307D|GNAS_uc002xzx.2_Missense_Mutation_p.A307D|GNAS_uc010gjr.2_Missense_Mutation_p.A257D|GNAS_uc002xzy.2_Missense_Mutation_p.A292D|GNAS_uc002yaa.2_Missense_Mutation_p.A352D|GNAS_uc010zzt.1_Missense_Mutation_p.A367D|GNAS_uc002yab.2_RNA|GNAS_uc002yad.2_Missense_Mutation_p.A257D|GNAS_uc002yae.2_Missense_Mutation_p.A291D	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	366		GTP; via amide nitrogen (By similarity).	A -> S (in AHO; paradoxical combination of AHO and testotoxicosis; constitutively activates adenylyl cyclase in vitro; accounts for the testotoxicosis phenotype; mutant form is quite stable at testis temperature; rapidly degraded at 37 degrees explaining the AHO phenotype caused by loss of Gs activity).		activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)					Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			---	---	---	---
TH1L	51497	broad.mit.edu	37	20	57561870	57561870	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57561870G>A	uc002yag.2	+	3	292	c.265G>A	c.(265-267)GCT>ACT	p.A89T	TH1L_uc010zzu.1_Missense_Mutation_p.A89T|TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.A89T	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	89					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
TH1L	51497	broad.mit.edu	37	20	57568057	57568057	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57568057C>G	uc002yag.2	+	11	1288	c.1261C>G	c.(1261-1263)CCA>GCA	p.P421A	TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.P421A	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	421					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
PHACTR3	116154	broad.mit.edu	37	20	58330282	58330282	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58330282T>C	uc002yau.2	+	4	871	c.404T>C	c.(403-405)GTA>GCA	p.V135A	PHACTR3_uc002yat.2_Missense_Mutation_p.V132A|PHACTR3_uc010zzw.1_Missense_Mutation_p.V94A|PHACTR3_uc002yav.2_Missense_Mutation_p.V94A|PHACTR3_uc002yaw.2_Missense_Mutation_p.V94A|PHACTR3_uc002yax.2_Missense_Mutation_p.V94A	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	135						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58487421	58487421	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58487421A>G	uc002yaz.2	-						SYCP2_uc010gju.1_Intron	NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
CDH4	1002	broad.mit.edu	37	20	60509183	60509183	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60509183C>T	uc002ybn.1	+	15	2463	c.2449C>T	c.(2449-2451)CGT>TGT	p.R817C	CDH4_uc002ybp.1_Missense_Mutation_p.R743C	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	817	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)															---	---	---	---
PSMA7	5688	broad.mit.edu	37	20	60714246	60714246	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60714246G>A	uc002ybx.1	-	4	471	c.356C>T	c.(355-357)ACG>ATG	p.T119M	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	119					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)															---	---	---	---
LAMA5	3911	broad.mit.edu	37	20	60885488	60885488	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60885488T>C	uc002ycq.2	-	76	10654	c.10587A>G	c.(10585-10587)GGA>GGG	p.G3529G		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3529	Laminin G-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA5	3911	broad.mit.edu	37	20	60890201	60890201	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60890201T>C	uc002ycq.2	-	59	7997	c.7930A>G	c.(7930-7932)ACC>GCC	p.T2644A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2644	Potential.|Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
NTSR1	4923	broad.mit.edu	37	20	61341218	61341218	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61341218G>A	uc002ydf.2	+	1	1030	c.659G>A	c.(658-660)GGC>GAC	p.G220D		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	220	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)															---	---	---	---
DIDO1	11083	broad.mit.edu	37	20	61525226	61525226	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61525226C>A	uc002ydr.1	-	12	3157	c.2893G>T	c.(2893-2895)GGC>TGC	p.G965C	DIDO1_uc002yds.1_Missense_Mutation_p.G965C|DIDO1_uc002ydt.1_Missense_Mutation_p.G965C|DIDO1_uc002ydu.1_Missense_Mutation_p.G965C	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	965					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)																	---	---	---	---
COL20A1	57642	broad.mit.edu	37	20	61958163	61958163	+	Silent	SNP	C	T	T	rs146952253	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61958163C>T	uc011aau.1	+	31	3616	c.3516C>T	c.(3514-3516)ACC>ACT	p.T1172T	COL20A1_uc011aav.1_Silent_p.T993T	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1172	Collagen-like 2.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)																	---	---	---	---
PTK6	5753	broad.mit.edu	37	20	62163998	62163998	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62163998G>T	uc002yfg.2	-	5	753	c.713C>A	c.(712-714)GCC>GAC	p.A238D	PTK6_uc011aay.1_Missense_Mutation_p.A137D|PTK6_uc011aaz.1_5'UTR	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	238	Protein kinase.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)															---	---	---	---
PRIC285	85441	broad.mit.edu	37	20	62200870	62200870	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62200870C>T	uc002yfm.2	-	5	1611	c.719G>A	c.(718-720)CGT>CAT	p.R240H	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	240					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)															---	---	---	---
GMEB2	26205	broad.mit.edu	37	20	62250679	62250679	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62250679G>A	uc002yfp.1	-	1	551	c.72C>T	c.(70-72)GAC>GAT	p.D24D	GMEB2_uc002yfq.1_Silent_p.D24D	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	24				DGSGVEGVKTVLVTTNLAPHG -> CPAGCALRDPDSILSS LHFTR (in Ref. 6).	regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)															---	---	---	---
TPD52L2	7165	broad.mit.edu	37	20	62518961	62518961	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62518961A>G	uc002yhc.2	+						TPD52L2_uc002ygy.2_Intron|TPD52L2_uc002ygz.2_Intron|TPD52L2_uc002yha.2_Intron|TPD52L2_uc002yhb.2_Intron|TPD52L2_uc002yhd.2_Intron|TPD52L2_uc011abk.1_Intron|TPD52L2_uc011abl.1_Intron|TPD52L2_uc002yhe.2_Intron	NM_003288	NP_003279			tumor protein D52-like 2 isoform e						regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			ovary(1)|skin(1)	2	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)																	---	---	---	---
PCMTD2	55251	broad.mit.edu	37	20	62904640	62904640	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62904640T>C	uc002yil.3	+	6	973	c.773T>C	c.(772-774)ATT>ACT	p.I258T	PCMTD2_uc002yim.3_Missense_Mutation_p.I231T	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	258						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)																	---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10916386	10916386	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10916386A>G	uc002yip.1	-	20	1628	c.1260T>C	c.(1258-1260)ATT>ATC	p.I420I	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Silent_p.I402I|TPTE_uc002yir.1_Silent_p.I382I|TPTE_uc010gkv.1_Silent_p.I282I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	420	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10971316	10971316	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10971316A>C	uc002yip.1	-	5	409	c.41T>G	c.(40-42)ATC>AGC	p.I14S	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.I14S|TPTE_uc002yir.1_Missense_Mutation_p.I14S|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	14					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
HSPA13	6782	broad.mit.edu	37	21	15746385	15746385	+	Silent	SNP	A	G	G	rs138306035	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15746385A>G	uc002yjt.2	-	5	1038	c.969T>C	c.(967-969)AGT>AGC	p.S323S	HSPA13_uc011abx.1_Silent_p.S115S	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	323						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1																		---	---	---	---
USP25	29761	broad.mit.edu	37	21	17191087	17191087	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17191087T>C	uc002yjy.1	+	10	1219	c.1002T>C	c.(1000-1002)CAT>CAC	p.H334H	USP25_uc011aby.1_Silent_p.H334H|USP25_uc002yjz.1_Silent_p.H334H|USP25_uc010gla.1_Intron	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	334					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
TMPRSS15	5651	broad.mit.edu	37	21	19666595	19666595	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:19666595G>A	uc002ykw.2	-	21	2509	c.2478C>T	c.(2476-2478)TGC>TGT	p.C826C		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	826	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8																		---	---	---	---
GABPA	2551	broad.mit.edu	37	21	27136558	27136558	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:27136558A>G	uc002ylx.3	+	8	1367	c.840A>G	c.(838-840)ACA>ACG	p.T280T	GABPA_uc002yly.3_Silent_p.T280T	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	280					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CYYR1	116159	broad.mit.edu	37	21	27938613	27938613	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:27938613A>T	uc002ymd.2	-	2	470	c.148T>A	c.(148-150)TAC>AAC	p.Y50N	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.Y50N	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	50	Extracellular (Potential).					integral to membrane					0																		---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28315800	28315800	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28315800T>C	uc002ymg.2	-	3	2033	c.1304A>G	c.(1303-1305)GAT>GGT	p.D435G		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	435	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
ADAMTS5	11096	broad.mit.edu	37	21	28338270	28338270	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28338270G>A	uc002ymg.2	-	1	1170	c.441C>T	c.(439-441)GAC>GAT	p.D147D		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	147					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
RWDD2B	10069	broad.mit.edu	37	21	30380115	30380115	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30380115C>T	uc002yms.2	-	4	779	c.692G>A	c.(691-693)GGC>GAC	p.G231D	RWDD2B_uc002ymt.2_Missense_Mutation_p.G202D|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.G151D	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	231											0																		---	---	---	---
RWDD2B	10069	broad.mit.edu	37	21	30380209	30380209	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30380209T>C	uc002yms.2	-	4	685	c.598A>G	c.(598-600)AAA>GAA	p.K200E	RWDD2B_uc002ymt.2_Missense_Mutation_p.K171E|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.K120E	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	200											0																		---	---	---	---
BACH1	571	broad.mit.edu	37	21	30693734	30693734	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30693734T>C	uc002ynj.2	+	2	248	c.133T>C	c.(133-135)TTC>CTC	p.F45L	BACH1_uc002ynk.2_Missense_Mutation_p.F45L|BACH1_uc002ynl.2_RNA	NM_001186	NP_001177	O14867	BACH1_HUMAN	BTB and CNC homology 1 transcription factor	45	BTB.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2																		---	---	---	---
KRTAP24-1	643803	broad.mit.edu	37	21	31654914	31654914	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31654914T>A	uc002ynv.2	-	1	363	c.337A>T	c.(337-339)AGC>TGC	p.S113C		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	113						keratin filament	structural molecule activity				0																		---	---	---	---
KRTAP21-2	337978	broad.mit.edu	37	21	32119274	32119274	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:32119274A>G	uc011adh.1	-	1	247	c.247T>C	c.(247-249)TAC>CAC	p.Y83H		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	83						intermediate filament					0																		---	---	---	---
SFRS15	57466	broad.mit.edu	37	21	33057462	33057462	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33057462G>A	uc002ypd.2	-	19	2814	c.2388C>T	c.(2386-2388)GCC>GCT	p.A796A	SFRS15_uc002ype.2_Silent_p.A774A|SFRS15_uc010glu.2_Silent_p.A781A|SFRS15_uc002ypf.1_Silent_p.A470A	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	796						nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
SFRS15	57466	broad.mit.edu	37	21	33057701	33057701	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33057701A>G	uc002ypd.2	-						SFRS15_uc002ype.2_Intron|SFRS15_uc010glu.2_Intron|SFRS15_uc002ypf.1_Intron	NM_020706	NP_065757			splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0																		---	---	---	---
HUNK	30811	broad.mit.edu	37	21	33346910	33346910	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33346910A>G	uc002yph.2	+	7	1414	c.1054A>G	c.(1054-1056)ACC>GCC	p.T352A		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	352					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2																		---	---	---	---
MRAP	56246	broad.mit.edu	37	21	33686877	33686877	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33686877A>G	uc002ypk.2	+	5	409	c.222A>G	c.(220-222)GAA>GAG	p.E74E	URB1_uc002ypn.2_3'UTR	NM_206898	NP_996781	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	Error:Variant_position_missing_in_Q8TCY5_after_alignment					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0																		---	---	---	---
C21orf59	56683	broad.mit.edu	37	21	33976433	33976433	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:33976433A>G	uc002yqc.2	-	4	647	c.534_splice	c.e4+1	p.Q178_splice	C21orf59_uc002ypx.1_Splice_Site_p.Q71_splice|C21orf59_uc002ypy.1_Splice_Site_p.Q178_splice|C21orf59_uc002ypz.1_Splice_Site_p.Q178_splice|C21orf59_uc010glx.2_Splice_Site_p.Q79_splice|C21orf59_uc002yqd.2_Splice_Site_p.Q178_splice|C21orf59_uc002yqa.3_Intron|C21orf59_uc002yqb.3_Splice_Site_p.Q178_splice|C21orf59_uc011adr.1_Splice_Site_p.Q122_splice	NM_021254	NP_067077			hypothetical protein LOC56683							cytosol|nucleus					0																		---	---	---	---
GART	2618	broad.mit.edu	37	21	34876757	34876757	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34876757C>T	uc002yrx.2	-	21	2938	c.2803G>A	c.(2803-2805)GGA>AGA	p.G935R	GART_uc002yrz.2_Missense_Mutation_p.G935R|GART_uc010gmd.2_Missense_Mutation_p.G597R|GART_uc002yry.2_Missense_Mutation_p.G935R	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	935	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
SON	6651	broad.mit.edu	37	21	34922190	34922190	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34922190C>A	uc002yse.1	+	3	702	c.653C>A	c.(652-654)TCT>TAT	p.S218Y	SON_uc002ysb.1_Missense_Mutation_p.S218Y|SON_uc002ysc.2_Missense_Mutation_p.S218Y|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	218					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6																OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
SON	6651	broad.mit.edu	37	21	34927628	34927628	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34927628T>C	uc002yse.1	+	3	6140	c.6091T>C	c.(6091-6093)TCT>CCT	p.S2031P	SON_uc002ysb.1_Missense_Mutation_p.S2031P|SON_uc002ysc.2_Missense_Mutation_p.S2031P|SON_uc002ysd.2_Missense_Mutation_p.S1022P|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.S1022P	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2031	3 X tandem repeats of [ST]-P-[VLI]-R- [RL]-[RK]-[RF]-S-R.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6																		---	---	---	---
SON	6651	broad.mit.edu	37	21	34931991	34931991	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34931991T>C	uc002yse.1	+	6	6616	c.6567T>C	c.(6565-6567)GAT>GAC	p.D2189D	SON_uc002ysc.2_Silent_p.D2189D|SON_uc002ysd.2_Silent_p.D1180D|SON_uc002ysf.1_Silent_p.D217D|SON_uc002ysg.2_Silent_p.D1180D	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	2189					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6																		---	---	---	---
MRPS6	64968	broad.mit.edu	37	21	35497669	35497669	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:35497669C>T	uc002ytp.2	+	2	252	c.74C>T	c.(73-75)ACG>ATG	p.T25M		NM_032476	NP_115865	P82932	RT06_HUMAN	mitochondrial ribosomal protein S6	25					translation	mitochondrion|small ribosomal subunit	rRNA binding|structural constituent of ribosome			skin(1)	1																		---	---	---	---
CLIC6	54102	broad.mit.edu	37	21	36081844	36081844	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:36081844T>C	uc010gmt.1	+						CLIC6_uc002yuf.1_Intron	NM_053277	NP_444507			chloride intracellular channel 6							chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CBR3	874	broad.mit.edu	37	21	37507591	37507591	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37507591T>C	uc002yve.2	+	1	329	c.101T>C	c.(100-102)GTG>GCG	p.V34A	uc002yvc.1_Intron|uc002yvd.1_Intron	NM_001236	NP_001227	O75828	CBR3_HUMAN	carbonyl reductase 3	34	NADP.					cytosol|nucleus	carbonyl reductase (NADPH) activity|NADPH binding				0																		---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38538528	38538528	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38538528G>A	uc002yvz.2	+	33	4117	c.4012G>A	c.(4012-4014)GTG>ATG	p.V1338M	TTC3_uc011aee.1_Missense_Mutation_p.V1028M|TTC3_uc002ywa.2_Missense_Mutation_p.V1338M|TTC3_uc002ywb.2_Missense_Mutation_p.V1338M|TTC3_uc010gnf.2_Missense_Mutation_p.V1103M|TTC3_uc002ywc.2_Missense_Mutation_p.V1028M|TTC3_uc002ywd.1_Missense_Mutation_p.V402M	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1338					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
TTC3	7267	broad.mit.edu	37	21	38538886	38538886	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38538886A>G	uc002yvz.2	+	33	4475	c.4370A>G	c.(4369-4371)AAC>AGC	p.N1457S	TTC3_uc011aee.1_Missense_Mutation_p.N1147S|TTC3_uc002ywa.2_Missense_Mutation_p.N1457S|TTC3_uc002ywb.2_Missense_Mutation_p.N1457S|TTC3_uc010gnf.2_Missense_Mutation_p.N1222S|TTC3_uc002ywc.2_Missense_Mutation_p.N1147S|TTC3_uc002ywd.1_Missense_Mutation_p.N521S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1457					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)																---	---	---	---
DYRK1A	1859	broad.mit.edu	37	21	38862610	38862610	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:38862610G>A	uc002ywk.2	+	6	873	c.798G>A	c.(796-798)GCG>GCA	p.A266A	DYRK1A_uc002ywi.2_Silent_p.A266A|DYRK1A_uc002ywj.2_Silent_p.A257A|DYRK1A_uc002ywl.2_Silent_p.A266A|DYRK1A_uc002ywm.2_Silent_p.A266A|DYRK1A_uc011aei.1_Silent_p.A27A	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	266	Protein kinase.			A -> V (in Ref. 6; CAA05059).	nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4																		---	---	---	---
KCNJ15	3772	broad.mit.edu	37	21	39671704	39671704	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:39671704G>A	uc002ywv.2	+	4	823	c.521G>A	c.(520-522)CGG>CAG	p.R174Q	KCNJ15_uc002yww.2_Missense_Mutation_p.R174Q|KCNJ15_uc002ywx.2_Missense_Mutation_p.R174Q	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	174	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6																		---	---	---	---
BRWD1	54014	broad.mit.edu	37	21	40578152	40578152	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40578152T>C	uc002yxk.1	-	37	4385	c.4246A>G	c.(4246-4248)AAG>GAG	p.K1416E	BRWD1_uc010goc.1_Missense_Mutation_p.K59E|BRWD1_uc002yxl.2_Missense_Mutation_p.K1416E|BRWD1_uc010god.1_Missense_Mutation_p.K334E	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)																---	---	---	---
DSCAM	1826	broad.mit.edu	37	21	41457677	41457677	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:41457677A>G	uc002yyq.1	-	23	4436	c.3984T>C	c.(3982-3984)AGT>AGC	p.S1328S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1328	Extracellular (Potential).|Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)																---	---	---	---
FAM3B	54097	broad.mit.edu	37	21	42710359	42710359	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:42710359C>G	uc002yzb.1	+	3	364	c.218C>G	c.(217-219)ACC>AGC	p.T73S	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Missense_Mutation_p.T25S|FAM3B_uc002yzd.1_Missense_Mutation_p.T96S|FAM3B_uc011aeq.1_Missense_Mutation_p.T87S	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	73					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)																---	---	---	---
MX2	4600	broad.mit.edu	37	21	42780121	42780121	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:42780121A>G	uc002yzf.1	+	14	2213	c.2109A>G	c.(2107-2109)CGA>CGG	p.R703R	MX2_uc002yzg.1_Silent_p.R426R|MX2_uc010gop.1_Silent_p.R185R	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	703	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)																---	---	---	---
RIPK4	54101	broad.mit.edu	37	21	43161503	43161503	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43161503T>C	uc002yzn.1	-	8	1898	c.1850A>G	c.(1849-1851)TAC>TGC	p.Y617C		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	617						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7																		---	---	---	---
RIPK4	54101	broad.mit.edu	37	21	43169342	43169342	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43169342G>A	uc002yzn.1	-	4	693	c.645C>T	c.(643-645)GGC>GGT	p.G215G		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	215						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7																		---	---	---	---
NDUFV3	4731	broad.mit.edu	37	21	44326974	44326974	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44326974A>G	uc002zcn.2	+						NDUFV3_uc002zcm.2_Intron	NM_001001503	NP_001001503			NADH-ubiquinone oxidoreductase flavoprotein 3						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			ovary(2)	2				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)													---	---	---	---
SIK1	150094	broad.mit.edu	37	21	44840207	44840207	+	Silent	SNP	G	A	A	rs138160311	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44840207G>A	uc002zdf.2	-	8	1006	c.879C>T	c.(877-879)TCC>TCT	p.S293S		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	293					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7																		---	---	---	---
HSF2BP	11077	broad.mit.edu	37	21	45050308	45050308	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45050308T>C	uc002zdi.2	-	6	801	c.469A>G	c.(469-471)ACT>GCT	p.T157A	HSF2BP_uc011aey.1_Missense_Mutation_p.T82A	NM_007031	NP_008962	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding	157					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			skin(1)	1				STAD - Stomach adenocarcinoma(101;0.18)														---	---	---	---
PDXK	8566	broad.mit.edu	37	21	45163690	45163690	+	Splice_Site	SNP	T	C	C	rs111245794		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45163690T>C	uc002zdm.3	+	4	529	c.331_splice	c.e4+2	p.V111_splice	PDXK_uc010gpj.2_Splice_Site_p.V111_splice|PDXK_uc002zdn.3_Intron|PDXK_uc002zdq.3_Splice_Site_p.V38_splice	NM_003681	NP_003672			pyridoxal kinase						cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)													---	---	---	---
TRAPPC10	7109	broad.mit.edu	37	21	45509730	45509730	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45509730C>T	uc002zea.2	+	18	2955	c.2786C>T	c.(2785-2787)CCG>CTG	p.P929L	TRAPPC10_uc010gpo.2_Missense_Mutation_p.P640L|TRAPPC10_uc011afa.1_Missense_Mutation_p.P307L|TRAPPC10_uc011afb.1_Missense_Mutation_p.P34L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	929					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
PFKL	5211	broad.mit.edu	37	21	45725738	45725738	+	Intron	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45725738C>A	uc002zel.2	+						PFKL_uc002zek.2_Missense_Mutation_p.P49H|PFKL_uc011afd.1_Missense_Mutation_p.P49H	NM_002626	NP_002617			liver phosphofructokinase						fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)														---	---	---	---
C21orf29	54084	broad.mit.edu	37	21	45941907	45941907	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45941907G>A	uc002zfe.1	-	9	1491	c.1425C>T	c.(1423-1425)GGC>GGT	p.G475G	C21orf29_uc010gpv.1_Silent_p.G407G	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	475	EAR 4.				cell adhesion	extracellular region	structural molecule activity				0																		---	---	---	---
KRTAP10-3	386682	broad.mit.edu	37	21	45978566	45978566	+	Silent	SNP	G	A	A	rs144613025	by1000genomes	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45978566G>A	uc002zfj.1	-	1	78	c.33C>T	c.(31-33)AGC>AGT	p.S11S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198696	NP_941969	P60369	KR103_HUMAN	keratin associated protein 10-3	11						keratin filament				skin(1)	1																		---	---	---	---
UBE2G2	7327	broad.mit.edu	37	21	46208000	46208000	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46208000C>T	uc002zfy.2	-	2	129	c.54G>A	c.(52-54)CTG>CTA	p.L18L	UBE2G2_uc002zfx.2_5'UTR	NM_003343	NP_003334	P60604	UB2G2_HUMAN	ubiquitin-conjugating enzyme E2G 2 isoform 1	18					protein K48-linked ubiquitination	cytosol	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(3)|central_nervous_system(1)	4				Colorectal(79;0.0638)														---	---	---	---
ITGB2	3689	broad.mit.edu	37	21	46323290	46323290	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46323290G>A	uc002zgd.2	-	4	533	c.489C>T	c.(487-489)TCC>TCT	p.S163S	ITGB2_uc002zge.2_Silent_p.S163S|ITGB2_uc002zgf.3_Silent_p.S163S|ITGB2_uc011afl.1_Silent_p.S85S|ITGB2_uc010gpw.2_Intron|ITGB2_uc002zgg.2_Silent_p.S163S	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	163	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)													---	---	---	---
ITGB2	3689	broad.mit.edu	37	21	46323305	46323305	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46323305G>A	uc002zgd.2	-	4	518	c.474C>T	c.(472-474)AAC>AAT	p.N158N	ITGB2_uc002zge.2_Silent_p.N158N|ITGB2_uc002zgf.3_Silent_p.N158N|ITGB2_uc011afl.1_Silent_p.N80N|ITGB2_uc010gpw.2_Intron|ITGB2_uc002zgg.2_Silent_p.N158N	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	158	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)													---	---	---	---
ITGB2	3689	broad.mit.edu	37	21	46323369	46323369	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46323369T>C	uc002zgd.2	-	4	454	c.410A>G	c.(409-411)TAC>TGC	p.Y137C	ITGB2_uc002zge.2_Missense_Mutation_p.Y137C|ITGB2_uc002zgf.3_Missense_Mutation_p.Y137C|ITGB2_uc011afl.1_Missense_Mutation_p.Y59C|ITGB2_uc010gpw.2_Intron|ITGB2_uc002zgg.2_Missense_Mutation_p.Y137C	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	137	Extracellular (Potential).|VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)													---	---	---	---
COL18A1	80781	broad.mit.edu	37	21	46925269	46925269	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46925269C>T	uc011afs.1	+						COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Intron|SLC19A1_uc010gpy.1_Intron|COL18A1_uc002zhj.2_Intron|COL18A1_uc002zhk.2_5'Flank	NM_130444	NP_569711			alpha 1 type XVIII collagen isoform 3 precursor						cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)														---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47676879	47676879	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47676879G>A	uc002zir.1	-	17	3792	c.3756C>T	c.(3754-3756)GCC>GCT	p.A1252A	MCM3AP_uc002zip.1_5'UTR|MCM3AP_uc002ziq.1_Silent_p.A179A	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1252					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47704983	47704983	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47704983A>G	uc002zir.1	-	1	254	c.218T>C	c.(217-219)TTA>TCA	p.L73S	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	73					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47786508	47786508	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47786508G>T	uc002zji.3	+	15	2726	c.2619G>T	c.(2617-2619)GAG>GAT	p.E873D	PCNT_uc002zjj.2_Missense_Mutation_p.E755D	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	873					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47822252	47822252	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47822252A>G	uc002zji.3	+	27	5077	c.4970A>G	c.(4969-4971)GAC>GGC	p.D1657G	PCNT_uc002zjj.2_Missense_Mutation_p.D1539G	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1657	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
IL17RA	23765	broad.mit.edu	37	22	17590314	17590314	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17590314G>A	uc002zly.2	+	13	2338	c.2205G>A	c.(2203-2205)GCG>GCA	p.A735A	IL17RA_uc010gqt.2_Silent_p.A683A	NM_014339	NP_055154	Q96F46	I17RA_HUMAN	interleukin 17A receptor precursor	735	Cytoplasmic (Potential).				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			skin(2)	2		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)														---	---	---	---
CECR5	27440	broad.mit.edu	37	22	17619200	17619200	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17619200T>C	uc002zmf.2	-	8	1011	c.983A>G	c.(982-984)TAC>TGC	p.Y328C	CECR5_uc002zmd.2_Missense_Mutation_p.Y139C|CECR5_uc002zme.2_Missense_Mutation_p.Y120C|CECR5_uc002zmg.2_Missense_Mutation_p.Y128C|CECR5_uc002zmh.2_Missense_Mutation_p.Y298C	NM_033070	NP_149061	Q9BXW7	CECR5_HUMAN	cat eye syndrome chromosome region, candidate 5	328							hydrolase activity				0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)																---	---	---	---
CECR1	51816	broad.mit.edu	37	22	17670900	17670900	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17670900C>T	uc002zmk.1	-	5	1116	c.904G>A	c.(904-906)GCA>ACA	p.A302T	CECR1_uc010gqu.1_Missense_Mutation_p.A302T|CECR1_uc011agi.1_Missense_Mutation_p.A260T|CECR1_uc011agj.1_3'UTR|CECR1_uc002zmj.1_Missense_Mutation_p.A61T	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	302					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)																---	---	---	---
CECR1	51816	broad.mit.edu	37	22	17684503	17684503	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:17684503A>G	uc002zmk.1	-	3	915	c.703T>C	c.(703-705)TTC>CTC	p.F235L	CECR1_uc010gqu.1_Missense_Mutation_p.F235L|CECR1_uc011agi.1_Missense_Mutation_p.F193L|CECR1_uc011agj.1_Missense_Mutation_p.F193L	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	235					adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)																---	---	---	---
CECR2	27443	broad.mit.edu	37	22	18018207	18018207	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18018207A>G	uc010gqw.1	+	10	1299	c.1173_splice	c.e10-2	p.L391_splice	CECR2_uc010gqv.1_Splice_Site_p.L250_splice|CECR2_uc002zml.2_Splice_Site_p.L250_splice|CECR2_uc002zmn.2_Splice_Site_p.L10_splice	NM_031413	NP_113601			cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)														---	---	---	---
SLC25A18	83733	broad.mit.edu	37	22	18070770	18070770	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18070770G>A	uc002zmp.1	+	9	1149	c.655G>A	c.(655-657)GCG>ACG	p.A219T	SLC25A18_uc010gqx.2_Missense_Mutation_p.A219T|SLC25A18_uc002zmq.1_Missense_Mutation_p.A219T	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	219	Solcar 3.					integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)													---	---	---	---
TUBA8	51807	broad.mit.edu	37	22	18613870	18613870	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18613870G>A	uc002znv.1	+	5	1390	c.1317G>A	c.(1315-1317)TCG>TCA	p.S439S	TUBA8_uc002znr.2_Silent_p.S373S|TUBA8_uc002znw.1_Silent_p.S463S|TUBA8_uc002znx.1_Intron	NM_018943	NP_061816	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	439					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0																		---	---	---	---
USP18	11274	broad.mit.edu	37	22	18644674	18644674	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18644674C>A	uc002zny.2	+	4	710	c.372C>A	c.(370-372)GCC>GCA	p.A124A		NM_017414	NP_059110	Q9UMW8	UBP18_HUMAN	ubiquitin specific protease 18	124					regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway|ubiquitin-dependent protein catabolic process	cytosol|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)	1																		---	---	---	---
DGCR6	8214	broad.mit.edu	37	22	18898483	18898483	+	Missense_Mutation	SNP	A	G	G	rs144375273		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18898483A>G	uc002zoh.3	+	4	607	c.455A>G	c.(454-456)CAG>CGG	p.Q152R	DGCR6_uc002zog.2_RNA|DGCR6_uc002zoi.3_RNA	NM_005675	NP_005666	Q14129	DGCR6_HUMAN	DiGeorge syndrome critical region protein 6	152					cell adhesion|organ morphogenesis	nucleus|proteinaceous extracellular matrix				upper_aerodigestive_tract(1)|central_nervous_system(1)	2																		---	---	---	---
DGCR2	9993	broad.mit.edu	37	22	19028790	19028790	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19028790C>T	uc002zoq.1	-	9	1425	c.1177G>A	c.(1177-1179)GGC>AGC	p.G393S	DGCR2_uc002zor.1_Missense_Mutation_p.G169S|DGCR2_uc011agr.1_Missense_Mutation_p.G349S	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	393	Cytoplasmic (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)																	---	---	---	---
CDC45	8318	broad.mit.edu	37	22	19470330	19470330	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19470330A>G	uc002zpr.2	+	4	398	c.322A>G	c.(322-324)AAT>GAT	p.N108D	CDC45_uc011agz.1_Missense_Mutation_p.N103D|CDC45_uc011aha.1_Missense_Mutation_p.N108D|CDC45_uc002zps.2_Missense_Mutation_p.N108D|CDC45_uc002zpt.2_Intron	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	108					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1																		---	---	---	---
COMT	1312	broad.mit.edu	37	22	19950294	19950294	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19950294A>G	uc002zqu.2	+	3	494	c.245A>G	c.(244-246)TAC>TGC	p.Y82C	COMT_uc002zqt.2_Missense_Mutation_p.Y82C|COMT_uc002zqv.2_Missense_Mutation_p.Y82C|COMT_uc002zqw.2_Missense_Mutation_p.Y82C|COMT_uc011ahd.1_Missense_Mutation_p.Y82C|COMT_uc002zqx.2_Missense_Mutation_p.Y82C	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	82					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)													---	---	---	---
C22orf25	128989	broad.mit.edu	37	22	20024561	20024561	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20024561G>A	uc010grw.1	+						C22orf25_uc002zrb.1_Intron|C22orf25_uc002zrc.1_Intron|C22orf25_uc002zrd.1_Intron|C22orf25_uc002zre.2_Intron|C22orf25_uc010grx.2_Intron|C22orf25_uc011ahe.1_Intron|C22orf25_uc011ahf.1_Intron|C22orf25_uc011ahg.1_Silent_p.A41A|C22orf25_uc002zrg.2_Silent_p.A41A|C22orf25_uc011ahh.1_Intron|C22orf25_uc002zrf.2_Intron|C22orf25_uc011ahi.1_Intron|C22orf25_uc010gry.1_RNA|C22orf25_uc002zrh.1_5'UTR	NM_152906	NP_690870			hypothetical protein LOC128989												0	Colorectal(54;0.0533)																	---	---	---	---
ZDHHC8	29801	broad.mit.edu	37	22	20127090	20127090	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20127090T>C	uc002zrq.2	+	3	422	c.316T>C	c.(316-318)TGT>CGT	p.C106R	ZDHHC8_uc002zrr.1_Missense_Mutation_p.C106R|ZDHHC8_uc010gsa.2_Missense_Mutation_p.C4R	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	106	Cytoplasmic (Potential).|DHHC-type.					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)																	---	---	---	---
DGCR6L	85359	broad.mit.edu	37	22	20303653	20303653	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20303653G>A	uc002zrx.2	-	3	458	c.361C>T	c.(361-363)CGA>TGA	p.R121*	DGCR6L_uc010gsb.2_Intron|DGCR6L_uc010gsc.2_Nonsense_Mutation_p.R121*	NM_033257	NP_150282	Q9BY27	DGC6L_HUMAN	DiGeorge syndrome critical region gene 6 like	121	Potential.					nucleus					0	Colorectal(54;0.0993)																	---	---	---	---
ZNF74	7625	broad.mit.edu	37	22	20760494	20760494	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20760494G>A	uc010gsm.2	+	6	1383	c.1171G>A	c.(1171-1173)GGC>AGC	p.G391S	ZNF74_uc002zsg.2_Missense_Mutation_p.G320S|ZNF74_uc002zsh.2_Missense_Mutation_p.G391S|ZNF74_uc002zsi.2_Missense_Mutation_p.G320S|ZNF74_uc010gsn.2_Missense_Mutation_p.G320S	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	391	C2H2-type 6.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)															---	---	---	---
MED15	51586	broad.mit.edu	37	22	20891434	20891434	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20891434A>G	uc002zsp.2	+	2	179	c.99A>G	c.(97-99)GCA>GCG	p.A33A	MED15_uc002zsn.1_5'UTR|MED15_uc002zso.2_Silent_p.A33A|MED15_uc002zsq.2_Silent_p.A33A|MED15_uc010gso.2_Silent_p.A33A|MED15_uc002zsr.2_Silent_p.A7A|MED15_uc011ahs.1_Silent_p.A7A|MED15_uc011aht.1_Silent_p.A7A	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	33	Interaction with SREBF1.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)															---	---	---	---
MED15	51586	broad.mit.edu	37	22	20929471	20929471	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20929471C>T	uc002zsp.2	+	9	1304	c.1224C>T	c.(1222-1224)TCC>TCT	p.S408S	MED15_uc002zsq.2_Intron|MED15_uc010gso.2_Intron|MED15_uc002zsr.2_Intron|MED15_uc011ahs.1_Intron|MED15_uc002zss.2_Intron|MED15_uc011ahu.1_Silent_p.S134S|MED15_uc002zst.2_Silent_p.S24S	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	408	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)															---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21062346	21062346	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21062346T>C	uc002zsz.3	-	55	6355	c.6124A>G	c.(6124-6126)ATC>GTC	p.I2042V	PI4KA_uc010gsp.2_Missense_Mutation_p.I433V|PI4KA_uc002zsy.3_Missense_Mutation_p.I852V	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	2042					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
LZTR1	8216	broad.mit.edu	37	22	21350351	21350351	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21350351G>A	uc002zto.2	+	18	2272	c.2169G>A	c.(2167-2169)ATG>ATA	p.M723I	LZTR1_uc002ztn.2_Missense_Mutation_p.M682I|LZTR1_uc011ahy.1_Missense_Mutation_p.M704I|LZTR1_uc002ztp.2_Missense_Mutation_p.M29I	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	723	BTB 2.				anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)															---	---	---	---
HIC2	23119	broad.mit.edu	37	22	21799230	21799230	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21799230C>T	uc002zur.3	+	3	276	c.46C>T	c.(46-48)CGC>TGC	p.R16C	HIC2_uc002zus.3_Missense_Mutation_p.R16C	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	16					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)																---	---	---	---
HIC2	23119	broad.mit.edu	37	22	21799327	21799327	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21799327T>C	uc002zur.3	+	3	373	c.143T>C	c.(142-144)GTC>GCC	p.V48A	HIC2_uc002zus.3_Missense_Mutation_p.V48A	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	48	BTB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)																---	---	---	---
HIC2	23119	broad.mit.edu	37	22	21800502	21800502	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21800502A>G	uc002zur.3	+	3	1548	c.1318A>G	c.(1318-1320)AAC>GAC	p.N440D	HIC2_uc002zus.3_Missense_Mutation_p.N440D	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	440					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)																---	---	---	---
UBE2L3	7332	broad.mit.edu	37	22	21947247	21947247	+	Splice_Site	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21947247T>C	uc002zva.1	+	2	200	c.123_splice	c.e2+2	p.P41_splice	UBE2L3_uc011aig.1_Intron|UBE2L3_uc002zuz.1_Splice_Site_p.P41_splice|UBE2L3_uc010gti.1_Splice_Site	NM_003347	NP_003338			ubiquitin-conjugating enzyme E2L 3						cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0	Colorectal(54;0.105)																	---	---	---	---
UBE2L3	7332	broad.mit.edu	37	22	21968855	21968855	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21968855C>T	uc002zva.1	+						UBE2L3_uc011aig.1_Intron|UBE2L3_uc002zuz.1_Missense_Mutation_p.A107V|UBE2L3_uc010gti.1_Intron	NM_003347	NP_003338			ubiquitin-conjugating enzyme E2L 3						cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0	Colorectal(54;0.105)																	---	---	---	---
CCDC116	164592	broad.mit.edu	37	22	21989105	21989105	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21989105C>T	uc002zve.2	+	4	846	c.753C>T	c.(751-753)GGC>GGT	p.G251G	CCDC116_uc011aih.1_Silent_p.G251G	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	251										ovary(1)|skin(1)	2	Colorectal(54;0.105)																	---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	22707660	22707660	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22707660T>C	uc011aim.1	+											Parts of antibodies, mostly variable regions.												0																		---	---	---	---
LOC96610	96610	broad.mit.edu	37	22	23223513	23223513	+	RNA	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23223513G>A	uc011aim.1	+	334		c.14648G>A								Parts of antibodies, mostly variable regions.												0																		---	---	---	---
GNAZ	2781	broad.mit.edu	37	22	23438406	23438406	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23438406T>C	uc002zwu.1	+	2	1061	c.524T>C	c.(523-525)ATC>ACC	p.I175T	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	175						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)														---	---	---	---
BCR	613	broad.mit.edu	37	22	23603710	23603710	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23603710G>A	uc002zww.2	+	4	2331	c.1735G>A	c.(1735-1737)GAC>AAC	p.D579N	BCR_uc002zwx.2_Missense_Mutation_p.D579N|BCR_uc011aiy.1_Missense_Mutation_p.D168N|BCR_uc010gtx.1_Missense_Mutation_p.D82N|uc010gty.2_5'Flank	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	579	DH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML								---	---	---	---
CABIN1	23523	broad.mit.edu	37	22	24439497	24439497	+	Silent	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24439497C>A	uc002zzi.1	+	6	604	c.477C>A	c.(475-477)CCC>CCA	p.P159P	CABIN1_uc002zzj.1_Silent_p.P159P|CABIN1_uc002zzl.1_Silent_p.P159P|CABIN1_uc010guk.1_Silent_p.P114P|CABIN1_uc002zzk.1_Silent_p.P114P	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	159					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
SUSD2	56241	broad.mit.edu	37	22	24583571	24583571	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24583571T>C	uc002zzn.1	+	12	1968	c.1924T>C	c.(1924-1926)TAC>CAC	p.Y642H		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor	642	VWFD.|Extracellular (Potential).				immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---
SGSM1	129049	broad.mit.edu	37	22	25243746	25243746	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:25243746G>A	uc003abg.2	+	4	442	c.285G>A	c.(283-285)GAG>GAA	p.E95E	SGSM1_uc003abh.2_Silent_p.E95E|SGSM1_uc010guu.1_Silent_p.E95E|SGSM1_uc003abj.2_Silent_p.E95E|SGSM1_uc003abi.1_Silent_p.E70E|SGSM1_uc003abf.2_Silent_p.E95E	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	95	RUN.					Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5																		---	---	---	---
SEZ6L	23544	broad.mit.edu	37	22	26688424	26688424	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26688424A>G	uc003acb.2	+	2	303	c.147A>G	c.(145-147)TCA>TCG	p.S49S	SEZ6L_uc003acc.2_Silent_p.S49S|SEZ6L_uc011akc.1_Silent_p.S49S|SEZ6L_uc003acd.2_Silent_p.S49S|SEZ6L_uc011akd.1_Silent_p.S49S|SEZ6L_uc003ace.2_Silent_p.S49S|SEZ6L_uc003acf.1_5'UTR|SEZ6L_uc010gvc.1_5'UTR	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	49	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
ASPHD2	57168	broad.mit.edu	37	22	26830248	26830248	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26830248A>G	uc003acg.2	+	2	1064	c.667A>G	c.(667-669)ACC>GCC	p.T223A		NM_020437	NP_065170	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	223	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			ovary(1)	1																		---	---	---	---
SRRD	402055	broad.mit.edu	37	22	26886097	26886097	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26886097A>G	uc010gve.2	+	5	704	c.697A>G	c.(697-699)AAC>GAC	p.N233D	SRRD_uc003acp.3_Missense_Mutation_p.N226D|uc003acu.1_5'Flank	NM_001013694	NP_001013716	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	233					rhythmic process						0																		---	---	---	---
TFIP11	24144	broad.mit.edu	37	22	26899657	26899657	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26899657A>G	uc003acr.2	-	6	997	c.623T>C	c.(622-624)GTT>GCT	p.V208A	TFIP11_uc003acs.2_Missense_Mutation_p.V208A|TFIP11_uc003act.2_Missense_Mutation_p.V208A	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	208					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
TPST2	8459	broad.mit.edu	37	22	26936888	26936888	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26936888A>G	uc003acv.2	-	2	877	c.709T>C	c.(709-711)TAC>CAC	p.Y237H	TPST2_uc003acw.2_Missense_Mutation_p.Y237H|TPST2_uc003acx.2_Missense_Mutation_p.Y237H|TPST2_uc011akf.1_Missense_Mutation_p.Y237H	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	237	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1																		---	---	---	---
CRYBA4	1413	broad.mit.edu	37	22	27024321	27024321	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:27024321G>A	uc003acz.3	+	5	405	c.370G>A	c.(370-372)GAT>AAT	p.D124N		NM_001886	NP_001877	P53673	CRBA4_HUMAN	crystallin, beta A4	124	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens				0																		---	---	---	---
ZNRF3	84133	broad.mit.edu	37	22	29444383	29444383	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29444383C>T	uc003aeg.2	+	7	784	c.619C>T	c.(619-621)CGG>TGG	p.R207W	ZNRF3_uc003aeh.1_Missense_Mutation_p.R207W	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	307	RING-type; atypical.|Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1																		---	---	---	---
KREMEN1	83999	broad.mit.edu	37	22	29533411	29533411	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29533411C>T	uc011akm.1	+	6	726	c.713C>T	c.(712-714)ACG>ATG	p.T238M	KREMEN1_uc003ael.2_Missense_Mutation_p.T238M|KREMEN1_uc011akn.1_Missense_Mutation_p.T121M	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	236	Extracellular (Potential).|CUB.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5																		---	---	---	---
EWSR1	2130	broad.mit.edu	37	22	29696151	29696151	+	Nonstop_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29696151G>T	uc003aet.2	+	17	2299	c.1971G>T	c.(1969-1971)TAG>TAT	p.*657Y	EWSR1_uc003aev.2_Nonstop_Mutation_p.*662Y|EWSR1_uc003aew.2_Nonstop_Mutation_p.*601Y|EWSR1_uc003aex.2_Nonstop_Mutation_p.*656Y|EWSR1_uc003aey.2_Nonstop_Mutation_p.*452Y|EWSR1_uc003aez.2_Nonstop_Mutation_p.*318Y	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	657					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254								T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								---	---	---	---
GAS2L1	10634	broad.mit.edu	37	22	29708221	29708221	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29708221G>A	uc003afa.1	+	7	1980	c.1781G>A	c.(1780-1782)CGA>CAA	p.R594Q	GAS2L1_uc010gvm.1_Missense_Mutation_p.R367Q|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Missense_Mutation_p.R594Q|GAS2L1_uc003afd.1_3'UTR|GAS2L1_uc003afe.1_3'UTR	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	594					cell cycle arrest	cytoplasm|cytoskeleton					0																		---	---	---	---
AP1B1	162	broad.mit.edu	37	22	29745201	29745201	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29745201G>A	uc003afj.2	-						AP1B1_uc003afi.2_Intron|AP1B1_uc003afk.2_Intron|AP1B1_uc003afl.2_Intron|AP1B1_uc011ako.1_Intron	NM_001127	NP_001118			adaptor-related protein complex 1 beta 1 subunit						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
AP1B1	162	broad.mit.edu	37	22	29754783	29754783	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29754783C>T	uc003afj.2	-	5	641	c.457G>A	c.(457-459)GCC>ACC	p.A153T	AP1B1_uc003afi.2_Missense_Mutation_p.A153T|AP1B1_uc003afk.2_Missense_Mutation_p.A153T|AP1B1_uc003afl.2_Missense_Mutation_p.A153T	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	153					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
RFPL1	5988	broad.mit.edu	37	22	29837596	29837596	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29837596G>A	uc003afn.2	+	2	648	c.439G>A	c.(439-441)GTC>ATC	p.V147I	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	147	B30.2/SPRY.						zinc ion binding				0																		---	---	---	---
NF2	4771	broad.mit.edu	37	22	30064373	30064373	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:30064373G>T	uc003age.3	+	10	1380	c.937G>T	c.(937-939)GCC>TCC	p.A313S	NF2_uc003afy.3_Missense_Mutation_p.A313S|NF2_uc003afz.3_Missense_Mutation_p.A230S|NF2_uc003agf.3_Missense_Mutation_p.A313S|NF2_uc003agb.3_Missense_Mutation_p.A236S|NF2_uc003agc.3_Missense_Mutation_p.A275S|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Missense_Mutation_p.A313S|NF2_uc003aga.3_Missense_Mutation_p.A271S|NF2_uc003agh.3_Missense_Mutation_p.A272S|NF2_uc003agi.3_Missense_Mutation_p.A230S|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.A275S|NF2_uc010gvp.2_Missense_Mutation_p.A6S	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	313					actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.A313fs*9(3)|p.L127_D382del(1)|p.I296_Q333del(1)|p.?(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728								D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				---	---	---	---
PLA2G3	50487	broad.mit.edu	37	22	31536087	31536087	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31536087G>A	uc003aka.2	-	1	383	c.254C>T	c.(253-255)GCT>GTT	p.A85V		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	85					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0																		---	---	---	---
LIMK2	3985	broad.mit.edu	37	22	31669457	31669457	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31669457G>A	uc003akh.2	+	14	1723	c.1578G>A	c.(1576-1578)ACG>ACA	p.T526T	LIMK2_uc003akg.2_Silent_p.T443T|LIMK2_uc003aki.2_Silent_p.T280T|LIMK2_uc003akj.2_Silent_p.T505T|LIMK2_uc003akk.2_Silent_p.T505T|LIMK2_uc011aln.1_Silent_p.T443T	NM_005569	NP_005560	P53671	LIMK2_HUMAN	LIM domain kinase 2 isoform 2a	526	Protein kinase.					mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			ovary(2)	2																OREG0026477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SFI1	9814	broad.mit.edu	37	22	32010791	32010791	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32010791G>C	uc003ale.2	+	28	3406	c.3013G>C	c.(3013-3015)GCG>CCG	p.A1005P	SFI1_uc003alf.2_Missense_Mutation_p.A974P|SFI1_uc003alg.2_Missense_Mutation_p.A923P|SFI1_uc011alp.1_Missense_Mutation_p.A911P|SFI1_uc011alq.1_Missense_Mutation_p.A950P|SFI1_uc003alh.2_RNA|SFI1_uc010gwi.2_RNA|SFI1_uc003ali.2_Missense_Mutation_p.A97P|SFI1_uc003alj.2_Missense_Mutation_p.Q76H	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	1005					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1																		---	---	---	---
DEPDC5	9681	broad.mit.edu	37	22	32229940	32229940	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32229940A>G	uc003als.2	+	25	2286	c.2144A>G	c.(2143-2145)GAC>GGC	p.D715G	DEPDC5_uc011als.1_Missense_Mutation_p.D637G|DEPDC5_uc011alu.1_Missense_Mutation_p.D715G|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Missense_Mutation_p.D715G|DEPDC5_uc003alu.2_Missense_Mutation_p.D155G|DEPDC5_uc003alv.2_RNA|DEPDC5_uc011alw.1_Missense_Mutation_p.D36G|DEPDC5_uc003alw.2_Missense_Mutation_p.D13G|DEPDC5_uc011alx.1_5'UTR|DEPDC5_uc011alt.1_Missense_Mutation_p.D609G	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	715					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8																		---	---	---	---
RFPL2	10739	broad.mit.edu	37	22	32586769	32586769	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32586769T>C	uc003amg.3	-	5	2063	c.1127A>G	c.(1126-1128)GAG>GGG	p.E376G	RFPL2_uc003ame.3_Missense_Mutation_p.E315G|RFPL2_uc003amf.3_Missense_Mutation_p.E286G|RFPL2_uc003amh.3_Missense_Mutation_p.E286G	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	376							zinc ion binding			skin(1)	1																		---	---	---	---
SLC5A4	6527	broad.mit.edu	37	22	32644771	32644771	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32644771T>C	uc003ami.2	-	4	333	c.331A>G	c.(331-333)ATT>GTT	p.I111V		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	111	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0																		---	---	---	---
SLC5A4	6527	broad.mit.edu	37	22	32650198	32650198	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32650198C>T	uc003ami.2	-	2	140	c.138G>A	c.(136-138)GCG>GCA	p.A46A		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	46	Helical; (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0																		---	---	---	---
BPIL2	254240	broad.mit.edu	37	22	32815402	32815402	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32815402A>G	uc003amn.2	-						BPIL2_uc010gwo.2_Intron|BPIL2_uc011amb.1_Intron	NM_174932	NP_777592			bactericidal/permeability-increasing							extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2																		---	---	---	---
TIMP3	7078	broad.mit.edu	37	22	33255366	33255366	+	3'UTR	SNP	C	T	T	rs151254004		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:33255366C>T	uc003anb.2	+	5					SYN3_uc003amx.2_Intron|SYN3_uc003amy.2_Intron|SYN3_uc003amz.2_Intron	NM_000362	NP_000353			tissue inhibitor of metalloproteinase 3						negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			lung(1)	1																		---	---	---	---
HMGXB4	10042	broad.mit.edu	37	22	35661177	35661177	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:35661177G>T	uc003anl.2	+	5	970	c.796G>T	c.(796-798)GGC>TGC	p.G266C	HMGXB4_uc011amh.1_Missense_Mutation_p.G157C|HMGXB4_uc003ank.2_Missense_Mutation_p.G157C	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	266					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
RBM9	23543	broad.mit.edu	37	22	36146507	36146507	+	Intron	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36146507G>C	uc003aon.3	-						RBM9_uc003aog.3_Intron|RBM9_uc003aol.3_Intron|RBM9_uc003aoj.3_Intron|RBM9_uc003aok.3_Intron|RBM9_uc003aoh.3_Intron|RBM9_uc003aom.3_Intron|RBM9_uc010gwu.2_Intron|RBM9_uc003aoo.3_Intron	NM_001082578	NP_001076047			RNA binding motif protein 9 isoform 5						estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0																		---	---	---	---
APOL1	8542	broad.mit.edu	37	22	36661621	36661621	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36661621A>G	uc003apf.2	+	6	907	c.739A>G	c.(739-741)AGC>GGC	p.S247G	APOL1_uc011amn.1_Missense_Mutation_p.S124G|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.S263G|APOL1_uc011amo.1_Missense_Mutation_p.S124G|APOL1_uc011amp.1_Missense_Mutation_p.S247G|APOL1_uc011amq.1_Missense_Mutation_p.S229G|APOL1_uc010gwx.2_Missense_Mutation_p.S124G	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	247					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3																		---	---	---	---
CACNG2	10369	broad.mit.edu	37	22	36960849	36960849	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36960849T>C	uc003aps.1	-	4	803	c.521A>G	c.(520-522)TAC>TGC	p.Y174C		NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	174					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0																		---	---	---	---
KCTD17	79734	broad.mit.edu	37	22	37457578	37457578	+	Splice_Site	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37457578G>T	uc010gxb.2	+	8	807	c.785_splice	c.e8-1	p.G262_splice	KCTD17_uc011amv.1_Splice_Site_p.G245_splice|KCTD17_uc010gxc.2_Splice_Site_p.V205_splice	NM_024681	NP_078957			potassium channel tetramerisation domain							voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0																		---	---	---	---
RAC2	5880	broad.mit.edu	37	22	37637690	37637690	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37637690C>T	uc003arc.2	-	2	161	c.44G>A	c.(43-45)GGC>GAC	p.G15D		NM_002872	NP_002863	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2	15	GTP (By similarity).				axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
TRIOBP	11078	broad.mit.edu	37	22	38151115	38151115	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38151115A>T	uc003atr.2	+	14	5766	c.5495A>T	c.(5494-5496)GAG>GTG	p.E1832V	TRIOBP_uc003atu.2_Missense_Mutation_p.E1660V|TRIOBP_uc003atv.2_Missense_Mutation_p.E119V|TRIOBP_uc003atw.2_Missense_Mutation_p.E119V|TRIOBP_uc003atx.1_5'Flank|TRIOBP_uc010gxh.2_5'Flank	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1832	PH.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)																	---	---	---	---
CSNK1E	1454	broad.mit.edu	37	22	38694806	38694806	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38694806C>A	uc003avj.2	-	7	1131	c.870G>T	c.(868-870)TGG>TGT	p.W290C	CSNK1E_uc003avk.2_Missense_Mutation_p.W290C|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.W290C|CSNK1E_uc003avo.2_Missense_Mutation_p.W290C|CSNK1E_uc003avp.1_Missense_Mutation_p.W290C|CSNK1E_uc003avq.1_Missense_Mutation_p.W290C	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	290					DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)															OREG0026559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CSNK1E	1454	broad.mit.edu	37	22	38694907	38694907	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38694907A>G	uc003avj.2	-	7	1030	c.769T>C	c.(769-771)TCC>CCC	p.S257P	CSNK1E_uc003avk.2_Missense_Mutation_p.S257P|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.S257P|CSNK1E_uc003avo.2_Missense_Mutation_p.S257P|CSNK1E_uc003avp.1_Missense_Mutation_p.S257P|CSNK1E_uc003avq.1_Missense_Mutation_p.S257P	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	257	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)															OREG0026559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KCNJ4	3761	broad.mit.edu	37	22	38823509	38823509	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38823509C>T	uc003avs.1	-	2	726	c.629G>A	c.(628-630)CGC>CAC	p.R210H	KCNJ4_uc003avt.1_Missense_Mutation_p.R210H	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	210	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)																	---	---	---	---
DDX17	10521	broad.mit.edu	37	22	38884247	38884247	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38884247T>C	uc003avy.3	-						DDX17_uc003avw.3_5'UTR|DDX17_uc010gxp.2_5'UTR|DDX17_uc003avx.3_Intron	NM_001098504	NP_001091974			DEAD box polypeptide 17 isoform 3						RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)																	---	---	---	---
DDX17	10521	broad.mit.edu	37	22	38897252	38897252	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38897252C>T	uc003avy.3	-	2	424	c.321G>A	c.(319-321)CCG>CCA	p.P107P	DDX17_uc003avx.3_Silent_p.P107P|DDX17_uc011anu.1_Silent_p.P20P	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	28					RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)																	---	---	---	---
DMC1	11144	broad.mit.edu	37	22	38962699	38962699	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38962699T>C	uc003avz.1	-	4	314	c.139A>G	c.(139-141)ACC>GCC	p.T47A	DMC1_uc011anv.1_Missense_Mutation_p.T47A|DMC1_uc003awa.1_Missense_Mutation_p.T47A	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	47					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)												Homologous_recombination					---	---	---	---
APOBEC3D	140564	broad.mit.edu	37	22	39421596	39421596	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39421596T>C	uc011aoe.1	+	4	579	c.525T>C	c.(523-525)AAT>AAC	p.N175N	APOBEC3D_uc011aod.1_Silent_p.N244N|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Silent_p.N175N|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	175					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)																	---	---	---	---
MGAT3	4248	broad.mit.edu	37	22	39884031	39884031	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39884031G>A	uc003axv.3	+	2	918	c.679G>A	c.(679-681)GAG>AAG	p.E227K	MGAT3_uc010gxy.2_Missense_Mutation_p.E227K	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	227	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)																	---	---	---	---
RPS19BP1	91582	broad.mit.edu	37	22	39925608	39925608	+	Silent	SNP	G	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39925608G>C	uc003ayb.2	-	4	427	c.300C>G	c.(298-300)GGC>GGG	p.G100G		NM_194326	NP_919307	Q86WX3	AROS_HUMAN	S19 binding protein	100						nucleolus|nucleoplasm					0	Melanoma(58;0.04)															OREG0026578	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40043875	40043875	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40043875G>A	uc003ayc.2	+	9	1511	c.1511G>A	c.(1510-1512)CGG>CAG	p.R504Q	CACNA1I_uc003ayd.2_Intron|CACNA1I_uc003aye.2_Missense_Mutation_p.R419Q|CACNA1I_uc003ayf.2_Intron	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	504	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40064365	40064365	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40064365T>C	uc003ayc.2	+	24	4173	c.4173T>C	c.(4171-4173)GAT>GAC	p.D1391D	CACNA1I_uc003ayd.2_Silent_p.D1356D|CACNA1I_uc003aye.2_Silent_p.D1306D|CACNA1I_uc003ayf.2_Silent_p.D1271D	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1391	Extracellular (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
ADSL	158	broad.mit.edu	37	22	40754911	40754911	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40754911A>G	uc003ayp.3	+	5	585	c.526A>G	c.(526-528)ATT>GTT	p.I176V	ADSL_uc003ays.3_Missense_Mutation_p.I176V|ADSL_uc003ayq.3_Missense_Mutation_p.I176V|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Missense_Mutation_p.I161V|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	176					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1																		---	---	---	---
SGSM3	27352	broad.mit.edu	37	22	40803576	40803576	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40803576C>T	uc003ayu.1	+						SGSM3_uc011aos.1_Intron|SGSM3_uc011aot.1_Intron|SGSM3_uc010gyd.1_Intron	NM_015705	NP_056520			small G protein signaling modulator 3						cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2																		---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40814987	40814987	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40814987C>T	uc003ayv.1	-	9	1662	c.1455G>A	c.(1453-1455)ACG>ACA	p.T485T	MKL1_uc003ayw.1_Silent_p.T485T|MKL1_uc010gye.1_Silent_p.T485T|MKL1_uc010gyf.1_Silent_p.T435T	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	485					positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40816591	40816591	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40816591A>G	uc003ayv.1	-						MKL1_uc003ayw.1_Intron|MKL1_uc010gye.1_Intron|MKL1_uc010gyf.1_Intron	NM_020831	NP_065882			megakaryoblastic leukemia 1 protein						positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
EP300	2033	broad.mit.edu	37	22	41573174	41573174	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41573174A>G	uc003azl.3	+	31	5854	c.5459A>G	c.(5458-5460)CAC>CGC	p.H1820R		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1820					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
EP300	2033	broad.mit.edu	37	22	41574435	41574435	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41574435A>G	uc003azl.3	+	31	7115	c.6720A>G	c.(6718-6720)GGA>GGG	p.G2240G		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2240	Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
L3MBTL2	83746	broad.mit.edu	37	22	41625571	41625571	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41625571G>A	uc003azo.2	+	16	1970	c.1916G>A	c.(1915-1917)CGA>CAA	p.R639Q	L3MBTL2_uc003azn.2_RNA|CHADL_uc003azq.3_3'UTR|CHADL_uc010gyj.2_3'UTR	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	639					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TOB2	10766	broad.mit.edu	37	22	41832509	41832509	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41832509C>T	uc003azz.1	-	2	1548	c.841G>A	c.(841-843)GGC>AGC	p.G281S		NM_016272	NP_057356	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	281				QGSGTPGPFGGSGAGTCNSSSFDMAQVFGGGANSLFLEKT -> RAAAPQARLEAVGLAPATAAALTWPRYLEVVPTASSWR RH (in Ref. 1; BAA10971).	female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				ovary(1)	1																		---	---	---	---
PMM1	5372	broad.mit.edu	37	22	41974807	41974807	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41974807T>C	uc003bal.2	-							NM_002676	NP_002667			phosphomannomutase 1						dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	metal ion binding|phosphomannomutase activity			ovary(1)	1																		---	---	---	---
PPPDE2	27351	broad.mit.edu	37	22	42016765	42016765	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42016765T>C	uc003ban.1	-	1	152	c.79A>G	c.(79-81)ATC>GTC	p.I27V	PPPDE2_uc011apb.1_RNA|XRCC6_uc003bao.1_5'Flank|XRCC6_uc003bap.1_5'Flank|XRCC6_uc011apc.1_5'Flank|XRCC6_uc003baq.1_5'Flank|XRCC6_uc003bar.1_5'Flank|XRCC6_uc003bas.1_5'Flank	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	27	PPPDE peptidase.										0																		---	---	---	---
SREBF2	6721	broad.mit.edu	37	22	42262964	42262964	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42262964G>A	uc003bbi.2	+	2	387	c.218G>A	c.(217-219)AGC>AAC	p.S73N	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron	NM_004599	NP_004590	Q12772	SRBP2_HUMAN	sterol regulatory element-binding transcription	73	Gly/Pro/Ser-rich.|Cytoplasmic (Potential).				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			breast(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
ARFGAP3	26286	broad.mit.edu	37	22	43218294	43218294	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43218294A>G	uc003bdd.2	-	9	1014	c.794T>C	c.(793-795)GTA>GCA	p.V265A	ARFGAP3_uc010gzf.2_Missense_Mutation_p.V221A|ARFGAP3_uc011apu.1_Missense_Mutation_p.V193A	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	265					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1																		---	---	---	---
MCAT	27349	broad.mit.edu	37	22	43529260	43529260	+	Missense_Mutation	SNP	A	G	G	rs113924126		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43529260A>G	uc003bdl.1	-	4	1011	c.962T>C	c.(961-963)GTC>GCC	p.V321A	MCAT_uc003bdm.1_3'UTR	NM_173467	NP_775738	Q8IVS2	FABD_HUMAN	mitochondrial malonyltransferase isoform a	321					fatty acid biosynthetic process	mitochondrion	[acyl-carrier-protein] S-malonyltransferase activity|binding			ovary(1)	1		Ovarian(80;0.0694)																---	---	---	---
SCUBE1	80274	broad.mit.edu	37	22	43604189	43604189	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43604189A>C	uc003bdt.1	-	20	2711	c.2623T>G	c.(2623-2625)TAC>GAC	p.Y875D		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	875	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)																---	---	---	---
MPPED1	758	broad.mit.edu	37	22	43830976	43830976	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43830976G>A	uc011apv.1	+	3	470	c.247G>A	c.(247-249)GCC>ACC	p.A83T	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.A83T|MPPED1_uc011apz.1_Missense_Mutation_p.A116T	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	83							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)																---	---	---	---
EFCAB6	64800	broad.mit.edu	37	22	44112809	44112809	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44112809T>C	uc003bdy.1	-	9	1016	c.801A>G	c.(799-801)GAA>GAG	p.E267E	EFCAB6_uc003bdz.1_Silent_p.E115E|EFCAB6_uc010gzi.1_Silent_p.E115E|EFCAB6_uc010gzk.1_RNA|EFCAB6_uc011aqa.1_Silent_p.E161E|EFCAB6_uc003bea.1_Silent_p.E264E|EFCAB6_uc003beb.3_Silent_p.E161E	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)																---	---	---	---
PARVG	64098	broad.mit.edu	37	22	44585064	44585064	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44585064C>T	uc011aqe.1	+	6	742	c.318C>T	c.(316-318)CTC>CTT	p.L106L	PARVG_uc003bep.2_Silent_p.L106L|PARVG_uc011aqf.1_Silent_p.L106L|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	106	CH 1.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)																---	---	---	---
PARVG	64098	broad.mit.edu	37	22	44592258	44592258	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44592258A>G	uc011aqe.1	+	11	1098	c.674A>G	c.(673-675)GAC>GGC	p.D225G	PARVG_uc003bep.2_Missense_Mutation_p.D225G|PARVG_uc011aqf.1_Missense_Mutation_p.D225G|PARVG_uc003beq.2_RNA|PARVG_uc003ber.2_RNA	NM_001137605	NP_001131077	Q9HBI0	PARVG_HUMAN	parvin, gamma	225	CH 2.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding				0		Ovarian(80;0.024)|all_neural(38;0.0299)																---	---	---	---
KIAA1644	85352	broad.mit.edu	37	22	44681392	44681392	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:44681392A>G	uc003bet.2	-	4	648	c.515T>C	c.(514-516)CTG>CCG	p.L172P		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	172	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)																---	---	---	---
PHF21B	112885	broad.mit.edu	37	22	45279040	45279040	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45279040G>A	uc003bfn.2	-	13	1673	c.1522C>T	c.(1522-1524)CTG>TTG	p.L508L	PHF21B_uc003bfm.2_Silent_p.L304L|PHF21B_uc011aqk.1_Silent_p.L454L|PHF21B_uc011aql.1_Silent_p.L466L	NM_138415	NP_612424	Q96EK2	PF21B_HUMAN	PHD finger protein 21B isoform 1	508							zinc ion binding			ovary(2)|skin(1)	3		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)														---	---	---	---
FAM118A	55007	broad.mit.edu	37	22	45719147	45719147	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45719147C>A	uc003bfz.3	+	4	755	c.139C>A	c.(139-141)CCT>ACT	p.P47T	FAM118A_uc003bga.3_Missense_Mutation_p.P47T	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	47	Helical; (Potential).					integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)														---	---	---	---
FAM118A	55007	broad.mit.edu	37	22	45719217	45719217	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45719217A>G	uc003bfz.3	+	4	825	c.209A>G	c.(208-210)CAC>CGC	p.H70R	FAM118A_uc003bga.3_Missense_Mutation_p.H70R	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	70						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)														---	---	---	---
FBLN1	2192	broad.mit.edu	37	22	45958979	45958979	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45958979T>C	uc003bgj.1	+						FBLN1_uc003bgh.2_Missense_Mutation_p.F629L|FBLN1_uc010gzz.2_Missense_Mutation_p.F667L|FBLN1_uc003bgi.1_Intron	NM_006486	NP_006477			fibulin 1 isoform D						interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
ATXN10	25814	broad.mit.edu	37	22	46239065	46239065	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46239065A>G	uc003bgm.1	+						ATXN10_uc011aqt.1_Intron|ATXN10_uc003bgn.1_Intron	NM_013236	NP_037368			ataxin 10						cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				ovary(1)|kidney(1)	2		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)														---	---	---	---
WNT7B	7477	broad.mit.edu	37	22	46318891	46318891	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46318891G>A	uc003bgo.2	-	4	1269	c.895C>T	c.(895-897)CCC>TCC	p.P299S	WNT7B_uc010haa.2_Missense_Mutation_p.P303S	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	299					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
PPARA	5465	broad.mit.edu	37	22	46614282	46614282	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46614282C>T	uc003bgw.1	+	6	758	c.492C>T	c.(490-492)GTC>GTT	p.V164V	PPARA_uc003bgx.1_Silent_p.V164V|PPARA_uc010hab.1_Silent_p.V164V|PPARA_uc003bha.2_Silent_p.V164V|PPARA_uc003bhb.1_Silent_p.V164V|PPARA_uc010hac.1_Missense_Mutation_p.S29L	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	164	Nuclear receptor.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)													---	---	---	---
PKDREJ	10343	broad.mit.edu	37	22	46655729	46655729	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46655729A>G	uc003bhh.2	-	1	3491	c.3491T>C	c.(3490-3492)ATT>ACT	p.I1164T		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1164	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)														---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46930187	46930187	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46930187C>T	uc003bhw.1	-	1	2881	c.2881G>A	c.(2881-2883)GTG>ATG	p.V961M		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	961	Extracellular (Potential).|Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
GRAMD4	23151	broad.mit.edu	37	22	47068811	47068811	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47068811T>A	uc003bhx.2	+	13	1195	c.1156T>A	c.(1156-1158)TAC>AAC	p.Y386N	GRAMD4_uc010had.2_Missense_Mutation_p.Y325N|GRAMD4_uc003bhy.2_5'Flank	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	386					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)														---	---	---	---
BRD1	23774	broad.mit.edu	37	22	50197911	50197911	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50197911C>T	uc003biv.2	-	2	1952	c.1465G>A	c.(1465-1467)GGG>AGG	p.G489R	BRD1_uc011arf.1_Missense_Mutation_p.G84R|BRD1_uc011arg.1_Missense_Mutation_p.G543R|BRD1_uc011arh.1_Missense_Mutation_p.G489R|BRD1_uc003biu.3_Missense_Mutation_p.G489R	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	489					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
TUBGCP6	85378	broad.mit.edu	37	22	50664613	50664613	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50664613A>G	uc003bkb.1	-	9	2211	c.1699T>C	c.(1699-1701)TTG>CTG	p.L567L	TUBGCP6_uc010har.1_Silent_p.L567L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'Flank|TUBGCP6_uc003bkd.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	567					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
PLXNB2	23654	broad.mit.edu	37	22	50715051	50715051	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50715051T>C	uc003bkv.3	-						PLXNB2_uc003bkt.1_Intron|PLXNB2_uc003bku.1_Intron	NM_012401	NP_036533			plexin B2 precursor						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)												OREG0026679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PLXNB2	23654	broad.mit.edu	37	22	50728169	50728169	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50728169G>A	uc003bkv.3	-	3	951	c.845C>T	c.(844-846)GCC>GTC	p.A282V		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	282	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
FAM116B	414918	broad.mit.edu	37	22	50755718	50755718	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50755718G>A	uc011aru.1	-						FAM116B_uc011arv.1_Intron	NM_001001794	NP_001001794			family with sequence similarity 116, member B												0		all_cancers(38;4.34e-09)|all_epithelial(38;3.03e-08)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SBF1	6305	broad.mit.edu	37	22	50897733	50897733	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50897733C>T	uc003blh.2	-	28	3972	c.3777G>A	c.(3775-3777)TCG>TCA	p.S1259S	SBF1_uc011arx.1_Silent_p.S923S	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1259	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SBF1	6305	broad.mit.edu	37	22	50898519	50898519	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50898519A>G	uc003blh.2	-	26	3548	c.3353T>C	c.(3352-3354)ATG>ACG	p.M1118T	SBF1_uc011arx.1_Missense_Mutation_p.M782T	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1118					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SBF1	6305	broad.mit.edu	37	22	50900413	50900413	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50900413G>T	uc003blh.2	-	20	2727	c.2532C>A	c.(2530-2532)ACC>ACA	p.T844T	SBF1_uc011arx.1_Silent_p.T508T|SBF1_uc003bli.2_Silent_p.T845T	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	844					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
SBF1	6305	broad.mit.edu	37	22	50906258	50906258	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50906258T>C	uc003blh.2	-	3	431	c.236A>G	c.(235-237)TAC>TGC	p.Y79C	SBF1_uc011arx.1_5'Flank|SBF1_uc003bli.2_Missense_Mutation_p.Y79C	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	79	UDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
MIOX	55586	broad.mit.edu	37	22	50928213	50928213	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50928213G>A	uc003bll.1	+	10	900	c.786G>A	c.(784-786)CCG>CCA	p.P262P	MIOX_uc003blm.1_Missense_Mutation_p.G258R|MIOX_uc003bln.1_Missense_Mutation_p.G219R	NM_017584	NP_060054	Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	262					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
KLHDC7B	113730	broad.mit.edu	37	22	50987826	50987826	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50987826G>A	uc003bmi.2	+	1	1365	c.1231G>A	c.(1231-1233)GGT>AGT	p.G411S		NM_138433	NP_612442	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	411	Kelch 3.									central_nervous_system(1)	1		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
CHKB	1120	broad.mit.edu	37	22	51018465	51018465	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51018465T>C	uc003bms.2	-	8	1083	c.865A>G	c.(865-867)ACT>GCT	p.T289A	CPT1B_uc003bmk.3_5'Flank|CPT1B_uc003bml.2_5'Flank|CPT1B_uc003bmm.2_5'Flank|CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Missense_Mutation_p.T80A|CHKB-CPT1B_uc003bmu.2_Missense_Mutation_p.T168A|CHKB_uc003bmv.2_Missense_Mutation_p.T289A|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	289					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)													---	---	---	---
MAPK8IP2	23542	broad.mit.edu	37	22	51040316	51040316	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51040316G>A	uc003bmx.2	+	2	281	c.164G>A	c.(163-165)TGT>TAT	p.C55Y	MAPK8IP2_uc003bmy.2_5'Flank	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	55					behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
ACR	49	broad.mit.edu	37	22	51177745	51177745	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:51177745C>T	uc003bnh.3	+	2	136	c.124C>T	c.(124-126)CGC>TGC	p.R42C	uc003bng.2_5'Flank|ACR_uc010hbh.1_Missense_Mutation_p.R42C	NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	42					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)														---	---	---	---
PPP2R3B	28227	broad.mit.edu	37	X	301587	301587	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:301587G>A	uc004cpg.2	-	10	1465	c.1264C>T	c.(1264-1266)CGA>TGA	p.R422*	PPP2R3B_uc004cpf.2_Nonsense_Mutation_p.R23*	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	422	EF-hand.				cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
CRLF2	64109	broad.mit.edu	37	X	1321300	1321300	+	RNA	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1321300T>C	uc004cpm.1	-	4		c.455A>G								Homo sapiens mRNA for IL-XR, complete cds.							extracellular region|integral to membrane|plasma membrane	receptor activity			haematopoietic_and_lymphoid_tissue(7)	7		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)						Mis|T	P2RY8|IGH@	B-ALL|Downs associated ALL								---	---	---	---
ZBED1	9189	broad.mit.edu	37	X	2406722	2406722	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:2406722C>G	uc004cqg.2	-	2	2240	c.2039G>C	c.(2038-2040)GGC>GCC	p.G680A	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.G680A	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	680						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
MXRA5	25878	broad.mit.edu	37	X	3227797	3227797	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:3227797A>T	uc004crg.3	-	7	8604	c.8447T>A	c.(8446-8448)CTC>CAC	p.L2816H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2816	Ig-like C2-type 12.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)																---	---	---	---
MXRA5	25878	broad.mit.edu	37	X	3239210	3239210	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:3239210T>C	uc004crg.3	-	5	4673	c.4516A>G	c.(4516-4518)ACC>GCC	p.T1506A		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1506						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)																---	---	---	---
PRKX	5613	broad.mit.edu	37	X	3573212	3573212	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:3573212A>G	uc010nde.2	-	3	944	c.577T>C	c.(577-579)TTC>CTC	p.F193L		NM_005044	NP_005035	P51817	PRKX_HUMAN	protein kinase, X-linked	193	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			skin(2)|lung(1)	3		all_lung(23;0.000396)|Lung NSC(23;0.00123)																---	---	---	---
NLGN4X	57502	broad.mit.edu	37	X	5950733	5950733	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:5950733T>C	uc010ndh.2	-						NLGN4X_uc004crp.2_Silent_p.E177E|NLGN4X_uc004crq.2_Intron|NLGN4X_uc010ndi.2_Intron|NLGN4X_uc004crr.2_Intron|NLGN4X_uc010ndj.2_Intron	NM_181332	NP_851849			X-linked neuroligin 4 precursor						brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4																		---	---	---	---
PNPLA4	8228	broad.mit.edu	37	X	7889822	7889822	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:7889822T>C	uc011mhq.1	-	4	505	c.343A>G	c.(343-345)ATC>GTC	p.I115V	PNPLA4_uc011mhr.1_Missense_Mutation_p.I115V|PNPLA4_uc011mhs.1_Missense_Mutation_p.I28V	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	115	Patatin.				lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)																---	---	---	---
KAL1	3730	broad.mit.edu	37	X	8538577	8538577	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:8538577A>G	uc004csf.2	-	7	1175	c.1025T>C	c.(1024-1026)GTC>GCC	p.V342A		NM_000216	NP_000207	P23352	KALM_HUMAN	Kallmann syndrome 1 protein precursor	342	Fibronectin type-III 2.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			ovary(3)|pancreas(1)	4																		---	---	---	---
CLCN4	1183	broad.mit.edu	37	X	10181871	10181871	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10181871T>A	uc004csy.3	+	11	2157	c.1727T>A	c.(1726-1728)ATC>AAC	p.I576N	CLCN4_uc011mid.1_Missense_Mutation_p.I482N	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	576	Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5																		---	---	---	---
MID1	4281	broad.mit.edu	37	X	10534991	10534991	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:10534991T>C	uc004cte.3	-	2	788	c.597A>G	c.(595-597)AAA>AAG	p.K199K	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Silent_p.K199K|MID1_uc004cth.3_Intron|MID1_uc004ctk.3_Silent_p.K199K|MID1_uc004cti.3_Silent_p.K199K|MID1_uc004ctj.3_Silent_p.K199K|MID1_uc011mie.1_Intron|MID1_uc004ctm.1_Silent_p.K199K|MID1_uc004ctn.1_Silent_p.K199K|MID1_uc004cto.1_Intron|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Silent_p.K199K|MID1_uc004ctu.2_Silent_p.K199K|MID1_uc004ctv.2_Intron|MID1_uc004ctw.2_Intron|MID1_uc010ndy.1_Silent_p.K199K|uc010ndz.1_5'Flank|MID1_uc004cty.2_Intron|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Silent_p.K199K|MID1_uc010nea.1_Intron|MID1_uc004cuc.1_Silent_p.K199K|MID1_uc004cud.1_Silent_p.K199K|MID1_uc004cue.1_Intron|MID1_uc004cuf.1_Intron	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	199	B box-type 2.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3																		---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11778586	11778586	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11778586C>T	uc004cuw.2	+	3	355	c.250C>T	c.(250-252)CGT>TGT	p.R84C	MSL3_uc004cuv.1_Missense_Mutation_p.R84C|MSL3_uc004cux.2_Missense_Mutation_p.R25C|MSL3_uc011mig.1_5'UTR|MSL3_uc011mih.1_Missense_Mutation_p.R72C|MSL3_uc004cuy.2_5'UTR|MSL3_uc011mii.1_5'UTR	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	84	Chromo.				histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
PRPS2	5634	broad.mit.edu	37	X	12837742	12837742	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:12837742C>T	uc004cvb.2	+	5	771	c.647C>T	c.(646-648)GCC>GTC	p.A216V	PRPS2_uc004cva.2_Missense_Mutation_p.A219V|PRPS2_uc010nec.2_Intron	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	216	Binding of phosphoribosylpyrophosphate (Potential).				nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0																		---	---	---	---
GEMIN8	54960	broad.mit.edu	37	X	14027269	14027269	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14027269A>T	uc004cwb.2	-	5	835	c.492T>A	c.(490-492)GAT>GAA	p.D164E	GEMIN8_uc004cwc.2_Missense_Mutation_p.D164E|GEMIN8_uc004cwd.2_Missense_Mutation_p.D164E	NM_017856	NP_060326	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	164	Potential.				spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding				0																		---	---	---	---
FANCB	2187	broad.mit.edu	37	X	14883327	14883327	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:14883327A>G	uc004cwg.1	-	3	574	c.306T>C	c.(304-306)AAT>AAC	p.N102N	FANCB_uc004cwh.1_Silent_p.N102N	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	102					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)												Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
ASB11	140456	broad.mit.edu	37	X	15311390	15311390	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15311390C>T	uc004cwp.1	-	4	422	c.422G>A	c.(421-423)AGC>AAC	p.S141N	ASB11_uc004cwo.1_Missense_Mutation_p.S120N|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.S124N	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	141	ANK 3.				intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
BMX	660	broad.mit.edu	37	X	15555366	15555366	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15555366T>C	uc004cww.2	+	14	1520	c.1332T>C	c.(1330-1332)GTT>GTC	p.V444V	BMX_uc004cwx.3_Silent_p.V444V|BMX_uc004cwy.3_Silent_p.V444V	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	444	Protein kinase.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)																	---	---	---	---
SYAP1	94056	broad.mit.edu	37	X	16775393	16775393	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16775393G>A	uc004cxp.2	+	8	985	c.892G>A	c.(892-894)GTG>ATG	p.V298M	SYAP1_uc004cxo.2_Missense_Mutation_p.V298M|SYAP1_uc011miv.1_Missense_Mutation_p.V264M	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	298										skin(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
RBBP7	5931	broad.mit.edu	37	X	16881118	16881118	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16881118A>G	uc004cxt.2	-	3	625	c.267T>C	c.(265-267)GAT>GAC	p.D89D	RBBP7_uc004cxs.1_Silent_p.D133D|RBBP7_uc004cxu.2_Silent_p.D89D	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	89	WD 1.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)																	---	---	---	---
NHS	4810	broad.mit.edu	37	X	17744010	17744010	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17744010A>G	uc004cxx.2	+	6	2059	c.1721A>G	c.(1720-1722)GAC>GGC	p.D574G	NHS_uc011mix.1_Missense_Mutation_p.D595G|NHS_uc004cxy.2_Missense_Mutation_p.D418G|NHS_uc004cxz.2_Missense_Mutation_p.D397G|NHS_uc004cya.2_Missense_Mutation_p.D297G	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	574						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)																	---	---	---	---
SCML1	6322	broad.mit.edu	37	X	17771410	17771410	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17771410G>A	uc004cyb.2	+	8	1213	c.888G>A	c.(886-888)ACG>ACA	p.T296T	SCML1_uc004cyc.2_Silent_p.T269T|SCML1_uc004cyd.2_Silent_p.T175T|SCML1_uc004cye.2_Silent_p.T175T	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	296	SAM.				anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)																	---	---	---	---
RAI2	10742	broad.mit.edu	37	X	17819375	17819375	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:17819375C>T	uc004cyf.2	-	3	1326	c.756G>A	c.(754-756)ATG>ATA	p.M252I	RAI2_uc004cyg.2_Missense_Mutation_p.M252I|RAI2_uc010nfa.2_Missense_Mutation_p.M252I|RAI2_uc004cyh.3_Missense_Mutation_p.M252I|RAI2_uc011miy.1_Missense_Mutation_p.M202I	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	252	Pro-rich.				embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
GPR64	10149	broad.mit.edu	37	X	19020962	19020962	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19020962A>G	uc004cyx.2	-	24	2394	c.2230_splice	c.e24+1	p.G744_splice	GPR64_uc004cyy.2_Splice_Site_p.G741_splice|GPR64_uc004cyz.2_Splice_Site_p.G730_splice|GPR64_uc004czb.2_Splice_Site_p.G744_splice|GPR64_uc004czc.2_Splice_Site_p.G728_splice|GPR64_uc004czd.2_Splice_Site_p.G720_splice|GPR64_uc004cze.2_Splice_Site_p.G714_splice|GPR64_uc004czf.2_Splice_Site_p.G706_splice|GPR64_uc004cza.2_Splice_Site_p.G722_splice|GPR64_uc004cyw.2_Splice_Site_p.G728_splice|GPR64_uc010nfj.2_Splice_Site_p.G625_splice	NM_001079858	NP_001073327			G protein-coupled receptor 64 isoform 1						neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
GPR64	10149	broad.mit.edu	37	X	19031984	19031984	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19031984A>G	uc004cyx.2	-	16	1083	c.919T>C	c.(919-921)TCA>CCA	p.S307P	GPR64_uc004cyy.2_Missense_Mutation_p.S304P|GPR64_uc004cyz.2_Missense_Mutation_p.S293P|GPR64_uc004czb.2_Missense_Mutation_p.S307P|GPR64_uc004czc.2_Missense_Mutation_p.S291P|GPR64_uc004czd.2_Missense_Mutation_p.S283P|GPR64_uc004cze.2_Missense_Mutation_p.S277P|GPR64_uc004czf.2_Missense_Mutation_p.S269P|GPR64_uc004cza.2_Missense_Mutation_p.S285P|GPR64_uc004cyw.2_Missense_Mutation_p.S291P|GPR64_uc010nfj.2_Missense_Mutation_p.S277P	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	307	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
GPR64	10149	broad.mit.edu	37	X	19041550	19041550	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:19041550T>C	uc004cyx.2	-	13	696	c.532A>G	c.(532-534)ACA>GCA	p.T178A	GPR64_uc004cyy.2_Missense_Mutation_p.T175A|GPR64_uc004cyz.2_Missense_Mutation_p.T164A|GPR64_uc004czb.2_Missense_Mutation_p.T178A|GPR64_uc004czc.2_Missense_Mutation_p.T162A|GPR64_uc004czd.2_Missense_Mutation_p.T154A|GPR64_uc004cze.2_Missense_Mutation_p.T148A|GPR64_uc004czf.2_Missense_Mutation_p.T140A|GPR64_uc004cza.2_Missense_Mutation_p.T156A|GPR64_uc004cyw.2_Missense_Mutation_p.T162A|GPR64_uc010nfj.2_Missense_Mutation_p.T148A	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	178	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
RPS6KA3	6197	broad.mit.edu	37	X	20190977	20190977	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:20190977T>C	uc004czu.2	-	15	1240	c.1240A>G	c.(1240-1242)AAC>GAC	p.N414D	RPS6KA3_uc011mjk.1_Missense_Mutation_p.N384D|RPS6KA3_uc004czv.2_Missense_Mutation_p.N401D|RPS6KA3_uc011mjl.1_Missense_Mutation_p.N385D|RPS6KA3_uc011mjm.1_Missense_Mutation_p.N386D	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	414					axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8																		---	---	---	---
CNKSR2	22866	broad.mit.edu	37	X	21581506	21581506	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21581506T>C	uc004czx.1	+	13	1580	c.1544T>C	c.(1543-1545)TTA>TCA	p.L515S	CNKSR2_uc004czw.2_Missense_Mutation_p.L515S|CNKSR2_uc011mjn.1_Missense_Mutation_p.L466S|CNKSR2_uc011mjo.1_Missense_Mutation_p.L485S|CNKSR2_uc004czy.2_Missense_Mutation_p.L107S	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	515	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2																		---	---	---	---
MBTPS2	51360	broad.mit.edu	37	X	21896666	21896666	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21896666A>G	uc004dae.2	+	9	1314	c.1117A>G	c.(1117-1119)ACC>GCC	p.T373A	MBTPS2_uc010nfr.2_5'UTR	NM_015884	NP_056968	O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase,	373	Cys-rich.|Lumenal (Probable).				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			ovary(1)	1																		---	---	---	---
MBTPS2	51360	broad.mit.edu	37	X	21896713	21896713	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21896713A>G	uc004dae.2	+	9	1361	c.1164A>G	c.(1162-1164)ATA>ATG	p.I388M	MBTPS2_uc010nfr.2_Translation_Start_Site	NM_015884	NP_056968	O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase,	388	Lumenal (Probable).				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			ovary(1)	1																		---	---	---	---
PHEX	5251	broad.mit.edu	37	X	22196458	22196458	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:22196458T>G	uc004dah.2	+	14	1754	c.1551T>G	c.(1549-1551)GAT>GAG	p.D517E	PHEX_uc011mjr.1_Missense_Mutation_p.D517E|PHEX_uc011mjs.1_Missense_Mutation_p.D420E	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	517	Extracellular (Potential).				biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3																		---	---	---	---
APOO	79135	broad.mit.edu	37	X	23876750	23876750	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:23876750T>C	uc004dax.2	-						APOO_uc004daw.2_Intron|APOO_uc004day.3_Intron	NM_024122	NP_077027			apolipoprotein O precursor						lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0																		---	---	---	---
GK	2710	broad.mit.edu	37	X	30742309	30742309	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30742309T>C	uc004dch.3	+						GK_uc010ngj.2_Intron|GK_uc004dci.3_Intron|GK_uc011mjz.1_Intron|GK_uc011mka.1_Intron|GK_uc010ngk.2_Intron	NM_203391	NP_976325			glycerol kinase isoform a						glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1																		---	---	---	---
GK	2710	broad.mit.edu	37	X	30745650	30745650	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30745650C>T	uc004dch.3	+						GK_uc010ngj.2_Silent_p.I544I|GK_uc004dci.3_Intron|GK_uc011mjz.1_Silent_p.I345I|GK_uc011mka.1_Intron|GK_uc010ngk.2_Silent_p.I339I	NM_203391	NP_976325			glycerol kinase isoform a						glycerol-3-phosphate metabolic process|triglyceride biosynthetic process	cytosol|mitochondrial outer membrane	ATP binding|glycerol kinase activity			central_nervous_system(1)	1																		---	---	---	---
TAB3	257397	broad.mit.edu	37	X	30870889	30870889	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30870889A>G	uc004dcj.2	-						TAB3_uc004dck.2_Intron|TAB3_uc010ngl.2_Intron	NM_152787	NP_690000			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
DMD	1756	broad.mit.edu	37	X	31222113	31222113	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31222113T>C	uc004dda.1	-	67	10016	c.9772A>G	c.(9772-9774)AAC>GAC	p.N3258D	DMD_uc004dcq.1_Missense_Mutation_p.N529D|DMD_uc004dcr.1_Missense_Mutation_p.N798D|DMD_uc004dcs.1_Missense_Mutation_p.N798D|DMD_uc004dct.1_Missense_Mutation_p.N798D|DMD_uc004dcu.1_Missense_Mutation_p.N798D|DMD_uc004dcv.1_Missense_Mutation_p.N798D|DMD_uc004dcw.2_Missense_Mutation_p.N1914D|DMD_uc004dcx.2_Missense_Mutation_p.N1917D|DMD_uc004dcz.2_Missense_Mutation_p.N3135D|DMD_uc004dcy.1_Missense_Mutation_p.N3254D|DMD_uc004ddb.1_Missense_Mutation_p.N3250D|DMD_uc004dcm.1_Missense_Mutation_p.N190D|DMD_uc004dcn.1_Missense_Mutation_p.N190D|DMD_uc004dco.1_Missense_Mutation_p.N190D|DMD_uc004dcp.1_Missense_Mutation_p.N190D|DMD_uc011mkb.1_Missense_Mutation_p.N190D|DMD_uc010ngm.2_Missense_Mutation_p.N190D	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3258	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
DMD	1756	broad.mit.edu	37	X	31496459	31496459	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31496459T>C	uc004dda.1	-	59	8945	c.8701A>G	c.(8701-8703)ACT>GCT	p.T2901A	DMD_uc004dcq.1_Missense_Mutation_p.T172A|DMD_uc004dcr.1_Missense_Mutation_p.T441A|DMD_uc004dcs.1_Missense_Mutation_p.T441A|DMD_uc004dct.1_Missense_Mutation_p.T441A|DMD_uc004dcu.1_Missense_Mutation_p.T441A|DMD_uc004dcv.1_Missense_Mutation_p.T441A|DMD_uc004dcw.2_Missense_Mutation_p.T1557A|DMD_uc004dcx.2_Missense_Mutation_p.T1560A|DMD_uc004dcz.2_Missense_Mutation_p.T2778A|DMD_uc004dcy.1_Missense_Mutation_p.T2897A|DMD_uc004ddb.1_Missense_Mutation_p.T2893A	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2901	Spectrin 20.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
FAM47A	158724	broad.mit.edu	37	X	34150216	34150216	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:34150216G>A	uc004ddg.2	-	1	213	c.180C>T	c.(178-180)TAC>TAT	p.Y60Y		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	60										ovary(4)|central_nervous_system(1)	5																		---	---	---	---
SYTL5	94122	broad.mit.edu	37	X	37935887	37935887	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:37935887C>T	uc004ddu.2	+	7	1156	c.622C>T	c.(622-624)CGG>TGG	p.R208W	SYTL5_uc004ddv.2_Missense_Mutation_p.R208W|SYTL5_uc004ddx.2_Missense_Mutation_p.R208W	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	208					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1																		---	---	---	---
TSPAN7	7102	broad.mit.edu	37	X	38530710	38530710	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:38530710T>C	uc004deg.3	+						TSPAN7_uc011mkj.1_Intron|TSPAN7_uc011mkk.1_Intron|TSPAN7_uc004deh.2_Intron	NM_004615	NP_004606			tetraspanin 7						interspecies interaction between organisms	integral to plasma membrane				ovary(1)	1																		---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39911469	39911469	+	Nonsense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39911469T>A	uc004den.3	-	15	5453	c.5161A>T	c.(5161-5163)AAG>TAG	p.K1721*	BCOR_uc004dep.3_Nonsense_Mutation_p.K1687*|BCOR_uc004deo.3_Nonsense_Mutation_p.K1669*|BCOR_uc010nhb.2_3'UTR|BCOR_uc004dem.3_Nonsense_Mutation_p.K1687*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	1721					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
ATP6AP2	10159	broad.mit.edu	37	X	40450603	40450603	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40450603T>C	uc004det.2	+	3	388	c.286T>C	c.(286-288)TAC>CAC	p.Y96H	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.Y20H|ATP6AP2_uc011mkm.1_Missense_Mutation_p.Y96H|ATP6AP2_uc011mkn.1_Missense_Mutation_p.Y96H	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	96	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0																		---	---	---	---
ATP6AP2	10159	broad.mit.edu	37	X	40464919	40464919	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40464919T>C	uc004det.2	+	9	1067	c.965T>C	c.(964-966)ATT>ACT	p.I322T	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Missense_Mutation_p.I246T|ATP6AP2_uc011mkm.1_Missense_Mutation_p.I290T|ATP6AP2_uc011mkn.1_Missense_Mutation_p.I244T|ATP6AP2_uc004deu.1_Missense_Mutation_p.I186T	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	322	Helical; (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0																		---	---	---	---
USP9X	8239	broad.mit.edu	37	X	40994031	40994031	+	Missense_Mutation	SNP	A	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40994031A>C	uc004dfb.2	+	5	1009	c.376A>C	c.(376-378)ATA>CTA	p.I126L	USP9X_uc004dfc.2_Missense_Mutation_p.I126L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	126					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6																		---	---	---	---
NYX	60506	broad.mit.edu	37	X	41333485	41333485	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41333485A>G	uc004dfh.2	+	2	1209	c.779A>G	c.(778-780)AAC>AGC	p.N260S	NYX_uc011mku.1_Missense_Mutation_p.N255S	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	260	LRR 9.				response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2																		---	---	---	---
EFHC2	80258	broad.mit.edu	37	X	44109680	44109680	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44109680G>A	uc004dgb.3	-	6	708	c.618C>T	c.(616-618)CAC>CAT	p.H206H		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	206							calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44922891	44922891	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44922891G>A	uc004dge.3	+	16	2127	c.1752G>A	c.(1750-1752)ACG>ACA	p.T584T	KDM6A_uc010nhk.2_Silent_p.T550T|KDM6A_uc011mkz.1_Silent_p.T636T|KDM6A_uc011mla.1_Silent_p.T539T|KDM6A_uc011mlb.1_Silent_p.T591T|KDM6A_uc011mlc.1_Silent_p.T288T|KDM6A_uc011mld.1_Silent_p.T223T	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	584					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44950035	44950035	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44950035A>G	uc004dge.3	+	26	4179	c.3804A>G	c.(3802-3804)GTA>GTG	p.V1268V	KDM6A_uc011mkz.1_Silent_p.V1320V|KDM6A_uc011mla.1_Silent_p.V1223V|KDM6A_uc011mlb.1_Silent_p.V1275V|KDM6A_uc011mlc.1_Silent_p.V972V|KDM6A_uc011mld.1_Silent_p.V907V	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1268					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
RBM10	8241	broad.mit.edu	37	X	47030548	47030548	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47030548G>A	uc004dhf.2	+	4	702	c.323G>A	c.(322-324)CGG>CAG	p.R108Q	RBM10_uc004dhe.1_Missense_Mutation_p.R98Q|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_Missense_Mutation_p.R108Q|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_Missense_Mutation_p.R173Q	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	108					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5																		---	---	---	---
CDK16	5127	broad.mit.edu	37	X	47084389	47084389	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47084389T>C	uc004dho.2	+	6	918	c.522T>C	c.(520-522)GGT>GGC	p.G174G	CDK16_uc011mli.1_Silent_p.G180G|CDK16_uc011mlj.1_Silent_p.G174G|CDK16_uc011mlk.1_Silent_p.G174G|CDK16_uc011mll.1_Silent_p.G248G	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	174	ATP (By similarity).|Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1																		---	---	---	---
CDK16	5127	broad.mit.edu	37	X	47087990	47087990	+	Missense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47087990A>T	uc004dho.2	+	15	1796	c.1400A>T	c.(1399-1401)GAG>GTG	p.E467V	CDK16_uc011mli.1_Missense_Mutation_p.E473V|CDK16_uc011mlk.1_Missense_Mutation_p.E474V|CDK16_uc011mll.1_Missense_Mutation_p.E541V	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	467							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1																		---	---	---	---
USP11	8237	broad.mit.edu	37	X	47100775	47100775	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47100775G>A	uc004dhp.2	+	8	1075	c.1075G>A	c.(1075-1077)GCA>ACA	p.A359T	USP11_uc004dhq.2_Missense_Mutation_p.A86T	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	359					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
USP11	8237	broad.mit.edu	37	X	47107040	47107040	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47107040G>A	uc004dhp.2	+	20	2696	c.2696G>A	c.(2695-2697)GGC>GAC	p.G899D	USP11_uc004dhq.2_Missense_Mutation_p.G625D	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	899					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
ARAF	369	broad.mit.edu	37	X	47428172	47428172	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47428172T>C	uc011mlq.1	+	11	1265	c.1132T>C	c.(1132-1134)TTT>CTT	p.F378L	ARAF_uc011mln.1_RNA|ARAF_uc011mlo.1_Missense_Mutation_p.F244L|ARAF_uc011mlp.1_Missense_Mutation_p.F378L|ARAF_uc004dic.1_Missense_Mutation_p.F159L	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	378	Protein kinase.			F -> V (in Ref. 6; AAB08754).	intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)											OREG0019759	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF182	7569	broad.mit.edu	37	X	47836190	47836190	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47836190A>G	uc004dir.2	-	7	1642	c.1296T>C	c.(1294-1296)TGT>TGC	p.C432C	ZNF182_uc004dis.2_Silent_p.C413C|ZNF182_uc004dit.2_Silent_p.C432C|ZNF182_uc011mlu.1_Silent_p.C412C	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	432	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3																		---	---	---	---
PORCN	64840	broad.mit.edu	37	X	48370833	48370833	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48370833A>G	uc010nie.1	+	5	651	c.493A>G	c.(493-495)ATC>GTC	p.I165V	PORCN_uc004djr.1_Missense_Mutation_p.I165V|PORCN_uc004djs.1_Missense_Mutation_p.I165V|PORCN_uc004djt.1_Missense_Mutation_p.I94V|PORCN_uc011mlx.1_Missense_Mutation_p.I94V|PORCN_uc004dju.1_Missense_Mutation_p.I34V|PORCN_uc004djv.1_Missense_Mutation_p.I165V|PORCN_uc004djw.1_Missense_Mutation_p.I165V	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	165	Helical; (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
KCND1	3750	broad.mit.edu	37	X	48826140	48826140	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48826140T>C	uc004dlx.1	-	1	2112	c.539A>G	c.(538-540)CAC>CGC	p.H180R	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	180	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3																		---	---	---	---
SYP	6855	broad.mit.edu	37	X	49048110	49048110	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49048110T>C	uc004dmz.1	-	6	742	c.726A>G	c.(724-726)AAA>AAG	p.K242K	SYP_uc011mmz.1_Silent_p.K124K|SYP_uc004dna.1_Silent_p.K236K	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	242	Cytoplasmic (Potential).				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)																---	---	---	---
CACNA1F	778	broad.mit.edu	37	X	49082529	49082529	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49082529C>T	uc004dnb.2	-	13	1588	c.1526G>A	c.(1525-1527)CGC>CAC	p.R509H	CACNA1F_uc010nip.2_Missense_Mutation_p.R498H	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	509	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)													---	---	---	---
PPP1R3F	89801	broad.mit.edu	37	X	49143293	49143293	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49143293T>C	uc004dnh.1	+	4	2157	c.2141T>C	c.(2140-2142)GTC>GCC	p.V714A	PPP1R3F_uc011mnd.1_Missense_Mutation_p.V385A|PPP1R3F_uc004dni.2_Missense_Mutation_p.V368A|PPP1R3F_uc004dnj.1_Missense_Mutation_p.V368A	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	714	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)																	---	---	---	---
PPP1R3F	89801	broad.mit.edu	37	X	49143411	49143411	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49143411T>C	uc004dnh.1	+	4	2275	c.2259T>C	c.(2257-2259)TGT>TGC	p.C753C	PPP1R3F_uc011mnd.1_Silent_p.C424C|PPP1R3F_uc004dni.2_Silent_p.C407C|PPP1R3F_uc004dnj.1_Silent_p.C407C	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	753	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)																	---	---	---	---
AKAP4	8852	broad.mit.edu	37	X	49957564	49957564	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49957564T>C	uc004dow.1	-	5	1924	c.1800A>G	c.(1798-1800)CAA>CAG	p.Q600Q	AKAP4_uc004dov.1_Silent_p.Q217Q|AKAP4_uc010njp.1_Silent_p.Q422Q|AKAP4_uc004dou.1_Silent_p.Q591Q	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	600					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)																	---	---	---	---
AKAP4	8852	broad.mit.edu	37	X	49958802	49958802	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49958802T>C	uc004dow.1	-	5	686	c.562A>G	c.(562-564)AAT>GAT	p.N188D	AKAP4_uc004dov.1_Missense_Mutation_p.N179D|AKAP4_uc010njp.1_Missense_Mutation_p.N10D|AKAP4_uc004dou.1_Missense_Mutation_p.N179D	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	188					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)																	---	---	---	---
DGKK	139189	broad.mit.edu	37	X	50146513	50146513	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:50146513G>A	uc010njr.1	-	6	1221	c.1161C>T	c.(1159-1161)GAC>GAT	p.D387D		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	387					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)																	---	---	---	---
SHROOM4	57477	broad.mit.edu	37	X	50370603	50370603	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:50370603C>T	uc004dpe.2	-						SHROOM4_uc004dpd.3_Intron	NM_020717	NP_065768			shroom family member 4						actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)																	---	---	---	---
TSPYL2	64061	broad.mit.edu	37	X	53114010	53114010	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53114010A>G	uc004drw.2	+	3	1091	c.959A>G	c.(958-960)AAC>AGC	p.N320S	TSPYL2_uc004drv.2_Missense_Mutation_p.N364S|TSPYL2_uc004drx.1_5'UTR	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	320					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0																		---	---	---	---
IQSEC2	23096	broad.mit.edu	37	X	53285092	53285092	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53285092G>A	uc004dsd.2	-	3	1090	c.889C>T	c.(889-891)CGC>TGC	p.R297C	IQSEC2_uc004dsc.2_Missense_Mutation_p.R92C	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	287					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3																		---	---	---	---
HUWE1	10075	broad.mit.edu	37	X	53563521	53563521	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53563521C>T	uc004dsp.2	-	79	12647	c.12245G>A	c.(12244-12246)CGT>CAT	p.R4082H	HUWE1_uc004dsn.2_Missense_Mutation_p.R2890H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	4082	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.R3972H(1)		ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17																		---	---	---	---
PHF8	23133	broad.mit.edu	37	X	54022124	54022124	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54022124A>G	uc004dsu.2	-	12	1504	c.1431_splice	c.e12+1	p.E477_splice	PHF8_uc004dst.2_Splice_Site_p.E441_splice|PHF8_uc004dsv.2_Splice_Site_p.E307_splice|PHF8_uc004dsw.2_Splice_Site_p.E441_splice|PHF8_uc004dsx.2_Splice_Site_p.E205_splice|PHF8_uc004dsy.2_Splice_Site_p.E441_splice	NM_015107	NP_055922			PHD finger protein 8						brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3																		---	---	---	---
FGD1	2245	broad.mit.edu	37	X	54475618	54475618	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54475618A>G	uc004dtg.2	-	15	2966	c.2232T>C	c.(2230-2232)AAT>AAC	p.N744N	FGD1_uc011moi.1_Silent_p.N502N	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	744	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
FGD1	2245	broad.mit.edu	37	X	54492003	54492003	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54492003T>A	uc004dtg.2	-	8	2251	c.1517A>T	c.(1516-1518)AAC>ATC	p.N506I	FGD1_uc011moi.1_Missense_Mutation_p.N264I	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	506	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
FGD1	2245	broad.mit.edu	37	X	54497788	54497788	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54497788C>T	uc004dtg.2	-	2	1174	c.440G>A	c.(439-441)CGT>CAT	p.R147H	FGD1_uc011moi.1_5'Flank	NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	147	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
TRO	7216	broad.mit.edu	37	X	54956700	54956700	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54956700T>C	uc004dtq.2	+	12	3650	c.3543T>C	c.(3541-3543)GGT>GGC	p.G1181G	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.G712G|TRO_uc004dtw.2_Silent_p.G784G|TRO_uc004dtx.2_Silent_p.G564G	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1181	62 X 10 AA approximate tandem repeats.|38; approximate.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1																		---	---	---	---
PAGE2	203569	broad.mit.edu	37	X	55117854	55117854	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55117854A>G	uc004duf.1	+	4	337	c.283A>G	c.(283-285)ATG>GTG	p.M95V		NM_207339	NP_997222	Q7Z2X7	GGEE2_HUMAN	P antigen family, member 2	95										ovary(2)	2																		---	---	---	---
USP51	158880	broad.mit.edu	37	X	55513438	55513438	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:55513438A>G	uc004dun.1	-	2	2014	c.1935T>C	c.(1933-1935)AAT>AAC	p.N645N	USP51_uc011moo.1_Silent_p.N349N	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	645					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3																		---	---	---	---
KLF8	11279	broad.mit.edu	37	X	56296710	56296710	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:56296710A>G	uc004dur.2	+	5	1800	c.854A>G	c.(853-855)TAC>TGC	p.Y285C	KLF8_uc011mop.1_Intron|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	285	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
FAM123B	139285	broad.mit.edu	37	X	63411777	63411777	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63411777C>T	uc004dvo.2	-	2	1663	c.1390G>A	c.(1390-1392)GCC>ACC	p.A464T		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	464					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112																		---	---	---	---
FAM123B	139285	broad.mit.edu	37	X	63413026	63413026	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:63413026G>A	uc004dvo.2	-	2	414	c.141C>T	c.(139-141)TCC>TCT	p.S47S		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	47					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112																		---	---	---	---
ZC4H2	55906	broad.mit.edu	37	X	64140121	64140121	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:64140121T>C	uc004dvu.2	-	3	326	c.238A>G	c.(238-240)ATC>GTC	p.I80V	ZC4H2_uc004dvv.2_Missense_Mutation_p.I57V|ZC4H2_uc011mov.1_Missense_Mutation_p.I57V|ZC4H2_uc011mow.1_Missense_Mutation_p.I80V|ZC4H2_uc004dvw.1_Missense_Mutation_p.I80V	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	80	Potential.						metal ion binding|protein binding			ovary(1)	1																		---	---	---	---
AR	367	broad.mit.edu	37	X	66942766	66942766	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:66942766T>G	uc004dwu.1	+	7	3662	c.2547T>G	c.(2545-2547)AAT>AAG	p.N849K	AR_uc004dwv.1_Missense_Mutation_p.N317K	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	848	Ligand-binding.|Interaction with MYST2.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)									Androgen_Insensitivity_Syndrome				---	---	---	---
OPHN1	4983	broad.mit.edu	37	X	67412815	67412815	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:67412815A>G	uc004dww.3	-	15	1516	c.1222T>C	c.(1222-1224)TAC>CAC	p.Y408H	OPHN1_uc011mpg.1_Missense_Mutation_p.Y408H	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	408	Rho-GAP.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2																		---	---	---	---
KIF4A	24137	broad.mit.edu	37	X	69606471	69606471	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69606471C>T	uc004dyg.2	+	19	2165	c.2038C>T	c.(2038-2040)CGT>TGT	p.R680C	KIF4A_uc010nkw.2_Missense_Mutation_p.R680C	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	680	Potential.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4																		---	---	---	---
DLG3	1741	broad.mit.edu	37	X	69668822	69668822	+	Intron	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69668822G>A	uc004dyi.1	+							NM_021120	NP_066943			synapse-associated protein 102 isoform a						axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)																	---	---	---	---
DLG3	1741	broad.mit.edu	37	X	69670589	69670589	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69670589G>A	uc004dyi.1	+	6	1269	c.941G>A	c.(940-942)AGC>AAC	p.S314N	DLG3_uc004dyj.1_5'Flank	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	314					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)																	---	---	---	---
ZMYM3	9203	broad.mit.edu	37	X	70471056	70471056	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70471056T>C	uc004dzh.1	-	4	837	c.750A>G	c.(748-750)AAA>AAG	p.K250K	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.K250K|ZMYM3_uc004dzj.1_Silent_p.K250K|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Silent_p.K250K|ZMYM3_uc004dzl.3_Silent_p.K250K|ZMYM3_uc004dzm.3_Silent_p.K250K	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	250					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)																	---	---	---	---
NHSL2	340527	broad.mit.edu	37	X	71359174	71359174	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71359174A>G	uc011mqa.1	+	6	1776	c.1776A>G	c.(1774-1776)CTA>CTG	p.L592L	NHSL2_uc004eak.1_Silent_p.L226L|NHSL2_uc010nli.2_Silent_p.L361L	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	592											0	Renal(35;0.156)																	---	---	---	---
ERCC6L	54821	broad.mit.edu	37	X	71425175	71425175	+	Missense_Mutation	SNP	C	T	T	rs78660817		TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71425175C>T	uc004eaq.1	-	2	3539	c.3442G>A	c.(3442-3444)GGA>AGA	p.G1148R	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Missense_Mutation_p.G1025R	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	1148					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)																	---	---	---	---
ERCC6L	54821	broad.mit.edu	37	X	71428266	71428266	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71428266A>G	uc004eaq.1	-	2	448	c.351T>C	c.(349-351)GGT>GGC	p.G117G	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_5'UTR	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	117	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)																	---	---	---	---
PHKA1	5255	broad.mit.edu	37	X	71846871	71846871	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71846871A>G	uc004eax.3	-	17	2044	c.1743T>C	c.(1741-1743)AGT>AGC	p.S581S	PHKA1_uc004eay.3_Silent_p.S581S|PHKA1_uc011mqi.1_Silent_p.S581S	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	581					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)																	---	---	---	---
TSIX	9383	broad.mit.edu	37	X	73042059	73042059	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73042059A>G	uc004ebn.2	+	1		c.30020A>G			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0																		---	---	---	---
TSIX	9383	broad.mit.edu	37	X	73043716	73043716	+	RNA	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73043716T>A	uc004ebn.2	+	1		c.31677T>A			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0																		---	---	---	---
TSIX	9383	broad.mit.edu	37	X	73045008	73045008	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73045008A>G	uc004ebn.2	+	1		c.32969A>G			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0																		---	---	---	---
XIST	7503	broad.mit.edu	37	X	73071282	73071282	+	RNA	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73071282A>G	uc004ebm.1	-	1		c.1307T>C				NR_001564				Homo sapiens cDNA: FLJ21545 fis, clone COL06195.												0																		---	---	---	---
KIAA2022	340533	broad.mit.edu	37	X	73961910	73961910	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73961910T>C	uc004eby.2	-	3	3099	c.2482A>G	c.(2482-2484)ACT>GCT	p.T828A		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	828					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15																		---	---	---	---
PGAM4	441531	broad.mit.edu	37	X	77224557	77224557	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77224557A>G	uc004ecy.1	-	1	579	c.579T>C	c.(577-579)ATT>ATC	p.I193I	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	193					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0																		---	---	---	---
P2RY10	27334	broad.mit.edu	37	X	78216198	78216198	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:78216198C>T	uc004ede.2	+	4	550	c.181C>T	c.(181-183)CGC>TGC	p.R61C	P2RY10_uc004edf.2_Missense_Mutation_p.R61C	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	61	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5																		---	---	---	---
POU3F4	5456	broad.mit.edu	37	X	82764004	82764004	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:82764004T>C	uc004eeg.2	+	1	736	c.672T>C	c.(670-672)GGT>GGC	p.G224G		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	224	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
CYLC1	1538	broad.mit.edu	37	X	83129273	83129273	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83129273T>C	uc004eei.1	+	4	1578	c.1557T>C	c.(1555-1557)TCT>TCC	p.S519S	CYLC1_uc004eeh.1_Silent_p.S518S	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	519	7.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5																		---	---	---	---
HDX	139324	broad.mit.edu	37	X	83723662	83723662	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:83723662T>C	uc004eek.1	-	3	1178	c.1069A>G	c.(1069-1071)ATT>GTT	p.I357V	HDX_uc011mqv.1_Missense_Mutation_p.I357V|HDX_uc004eel.1_Missense_Mutation_p.I299V	NM_144657	NP_653258	Q7Z353	HDX_HUMAN	highly divergent homeobox	357						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
SATL1	340562	broad.mit.edu	37	X	84362428	84362428	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84362428A>G	uc011mqx.1	-	1	1547	c.1547T>C	c.(1546-1548)GTG>GCG	p.V516A	SATL1_uc004een.2_Missense_Mutation_p.V516A	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	329	Gln-rich.						N-acetyltransferase activity			breast(2)	2																		---	---	---	---
CHM	1121	broad.mit.edu	37	X	85119781	85119781	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85119781G>A	uc004eet.2	-	15	1846	c.1816C>T	c.(1816-1818)CCC>TCC	p.P606S	CHM_uc011mqz.1_Missense_Mutation_p.P458S	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	606					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)																---	---	---	---
DACH2	117154	broad.mit.edu	37	X	85403701	85403701	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:85403701A>G	uc004eew.2	+	1	247	c.77A>G	c.(76-78)GAA>GGA	p.E26G	DACH2_uc004eex.2_Missense_Mutation_p.E26G|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5																		---	---	---	---
SRPX2	27286	broad.mit.edu	37	X	99920261	99920261	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:99920261G>A	uc004egb.2	+	6	1034	c.554G>A	c.(553-555)CGC>CAC	p.R185H		NM_014467	NP_055282	O60687	SRPX2_HUMAN	sushi-repeat-containing protein, X-linked 2	185	HYR.				angiogenesis|cell motility|cell-cell adhesion|positive regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation	cytoplasm|extracellular region	receptor binding			ovary(2)	2																		---	---	---	---
DRP2	1821	broad.mit.edu	37	X	100503594	100503594	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100503594T>C	uc004egz.2	+						DRP2_uc011mrh.1_Intron	NM_001939	NP_001930			dystrophin related protein 2						central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2																		---	---	---	---
GLA	2717	broad.mit.edu	37	X	100653514	100653514	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100653514T>C	uc004ehl.1	-	6	953	c.843A>G	c.(841-843)GTA>GTG	p.V281V		NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	281					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)													---	---	---	---
TCEAL2	140597	broad.mit.edu	37	X	101382092	101382092	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:101382092G>T	uc004eip.2	+	3	509	c.290G>T	c.(289-291)GGG>GTG	p.G97V		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0																		---	---	---	---
NXF3	56000	broad.mit.edu	37	X	102333485	102333485	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102333485A>G	uc004eju.2	-						NXF3_uc010noi.1_Intron	NM_022052	NP_071335			nuclear RNA export factor 3							cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
NXF3	56000	broad.mit.edu	37	X	102339744	102339744	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102339744A>G	uc004eju.2	-	2	167	c.96T>C	c.(94-96)AGT>AGC	p.S32S	NXF3_uc010noi.1_5'Flank|NXF3_uc011mrw.1_Silent_p.S32S|NXF3_uc011mrx.1_Intron	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	32						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3																		---	---	---	---
RAB40A	142684	broad.mit.edu	37	X	102754895	102754895	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:102754895T>G	uc004ekk.2	-	3	1132	c.790A>C	c.(790-792)AGC>CGC	p.S264R		NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	264					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0																		---	---	---	---
SERPINA7	6906	broad.mit.edu	37	X	105280958	105280958	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105280958T>C	uc004eme.1	-	1	108	c.92A>G	c.(91-93)CAT>CGT	p.H31R	SERPINA7_uc010npd.2_Missense_Mutation_p.H31R|SERPINA7_uc010npe.1_Missense_Mutation_p.H31R	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	31				CH -> DS (in Ref. 7; AA sequence).	regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)													---	---	---	---
MORC4	79710	broad.mit.edu	37	X	106228324	106228324	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106228324A>G	uc004emu.3	-	5	917	c.674_splice	c.e5+1	p.R225_splice	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Splice_Site_p.R225_splice|MORC4_uc004emw.3_Intron	NM_024657	NP_078933			zinc finger, CW type with coiled-coil domain 2								ATP binding|zinc ion binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	106846082	106846082	+	IGR	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106846082C>A								CXorf41 (358610 upstream) : PRPS1 (25572 downstream)																																			---	---	---	---
VSIG1	340547	broad.mit.edu	37	X	107310235	107310235	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107310235G>A	uc004eno.2	+	3	444	c.283G>A	c.(283-285)GAT>AAT	p.D95N	VSIG1_uc011msk.1_Missense_Mutation_p.D131N	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	95	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
ATG4A	115201	broad.mit.edu	37	X	107374535	107374535	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107374535G>A	uc004enr.2	+	4	362	c.239G>A	c.(238-240)CGC>CAC	p.R80H	ATG4A_uc004ent.2_Missense_Mutation_p.R80H|ATG4A_uc004ens.2_5'UTR|ATG4A_uc011msl.1_5'UTR|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_5'UTR	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	80					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1																		---	---	---	---
COL4A6	1288	broad.mit.edu	37	X	107408254	107408254	+	Missense_Mutation	SNP	C	T	T	rs113329155	byFrequency	TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:107408254C>T	uc004enw.3	-	39	3929	c.3826G>A	c.(3826-3828)GCT>ACT	p.A1276T	COL4A6_uc004env.3_Missense_Mutation_p.A1275T|COL4A6_uc011msn.1_Missense_Mutation_p.A1251T|COL4A6_uc010npk.2_Missense_Mutation_p.A1251T|COL4A6_uc010npj.2_5'Flank	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1276	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8														Alport_syndrome_with_Diffuse_Leiomyomatosis				---	---	---	---
NXT2	55916	broad.mit.edu	37	X	108785800	108785800	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:108785800A>G	uc004eof.1	+	4	456	c.312A>G	c.(310-312)GGA>GGG	p.G104G	NXT2_uc004eoe.1_Silent_p.G159G|NXT2_uc004eog.1_Silent_p.G76G	NM_018698	NP_061168	Q9NPJ8	NXT2_HUMAN	nuclear transport factor 2-like export factor 2	104	NTF2.				mRNA transport|protein transport	cytoplasm|nucleus				ovary(1)	1																		---	---	---	---
LUZP4	51213	broad.mit.edu	37	X	114540914	114540914	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114540914C>T	uc004eqa.2	+	4	521	c.487C>T	c.(487-489)CGA>TGA	p.R163*	LUZP4_uc004eqb.2_Nonsense_Mutation_p.R81*	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	163						nucleus				ovary(2)	2																		---	---	---	---
WDR44	54521	broad.mit.edu	37	X	117527127	117527127	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117527127C>G	uc004eqn.2	+	4	1144	c.719C>G	c.(718-720)ACT>AGT	p.T240S	WDR44_uc004eqo.2_Missense_Mutation_p.T240S|WDR44_uc011mtr.1_Missense_Mutation_p.T215S|WDR44_uc010nqi.2_5'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	240	Pro-rich.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
DOCK11	139818	broad.mit.edu	37	X	117770340	117770340	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117770340A>G	uc004eqp.2	+	36	3981	c.3918A>G	c.(3916-3918)TCA>TCG	p.S1306S	DOCK11_uc004eqq.2_Silent_p.S1085S	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1306					blood coagulation	cytosol	GTP binding			ovary(3)	3																		---	---	---	---
IL13RA1	3597	broad.mit.edu	37	X	117925753	117925753	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117925753A>G	uc004eqs.2	+	11	1263	c.1220A>G	c.(1219-1221)AAG>AGG	p.K407R	IL13RA1_uc004eqt.1_Intron	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	407	Cytoplasmic (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0																		---	---	---	---
PGRMC1	10857	broad.mit.edu	37	X	118374362	118374362	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118374362A>G	uc004erb.2	+	2	535	c.419A>G	c.(418-420)GAT>GGT	p.D140G	PGRMC1_uc011mts.1_Intron	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	140	Cytochrome b5 heme-binding.|Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0																		---	---	---	---
UPF3B	65109	broad.mit.edu	37	X	118979166	118979166	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118979166T>C	uc004erz.1	-	4	541	c.464A>G	c.(463-465)GAT>GGT	p.D155G	UPF3B_uc004esa.1_Missense_Mutation_p.D155G	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	155	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3																		---	---	---	---
NDUFA1	4694	broad.mit.edu	37	X	119007297	119007297	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119007297T>C	uc004esc.3	+	2	274	c.133T>C	c.(133-135)TGG>CGG	p.W45R	RNF113A_uc004esb.2_5'Flank	NM_004541	NP_004532	O15239	NDUA1_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	45					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			large_intestine(1)	1					NADH(DB00157)													---	---	---	---
RHOXF1	158800	broad.mit.edu	37	X	119249597	119249597	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:119249597C>T	uc004esk.1	-	1	251	c.176G>A	c.(175-177)GGC>GAC	p.G59D	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	59					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GRIA3	2892	broad.mit.edu	37	X	122599637	122599637	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122599637A>G	uc004etq.3	+						GRIA3_uc004etr.3_Missense_Mutation_p.K813E|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564			glutamate receptor, ionotrophic, AMPA 3 isoform						glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)													---	---	---	---
THOC2	57187	broad.mit.edu	37	X	122766892	122766892	+	Splice_Site	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:122766892C>A	uc004etu.2	-	21	2169	c.2137_splice	c.e21-1	p.G713_splice	THOC2_uc011muh.1_Splice_Site_p.G638_splice	NM_001081550	NP_001075019			THO complex 2						intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3																		---	---	---	---
SH2D1A	4068	broad.mit.edu	37	X	123504039	123504039	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123504039T>C	uc004euf.3	+	3	560	c.215T>C	c.(214-216)GTA>GCA	p.V72A	SH2D1A_uc004euh.3_Missense_Mutation_p.V72A|SH2D1A_uc004eug.3_Intron|SH2D1A_uc010nqw.2_Intron|SH2D1A_uc004eui.3_RNA|SH2D1A_uc010nqx.2_Intron	NM_002351	NP_002342	O60880	SH21A_HUMAN	SH2 domain protein 1A isoform 1	72	SH2.				cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity				0														X-linked_Lymphoproliferative_syndrome				---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123517933	123517933	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123517933T>C	uc004euj.2	-	29	6891	c.6827A>G	c.(6826-6828)AAC>AGC	p.N2276S	ODZ1_uc011muj.1_Missense_Mutation_p.N2282S|ODZ1_uc010nqy.2_Missense_Mutation_p.N2283S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2276	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123657295	123657295	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123657295T>C	uc004euj.2	-	17	3016	c.2952A>G	c.(2950-2952)CCA>CCG	p.P984P	ODZ1_uc011muj.1_Silent_p.P983P|ODZ1_uc010nqy.2_Silent_p.P984P	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	984	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
SMARCA1	6594	broad.mit.edu	37	X	128650306	128650306	+	Splice_Site	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:128650306A>G	uc004eun.3	-	3	541	c.428_splice	c.e3+1	p.D143_splice	SMARCA1_uc004eup.3_Splice_Site_p.D143_splice|SMARCA1_uc011muk.1_Splice_Site_p.D143_splice|SMARCA1_uc011mul.1_Splice_Site_p.D143_splice	NM_003069	NP_003060			SWI/SNF-related matrix-associated						ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4																		---	---	---	---
UTP14A	10813	broad.mit.edu	37	X	129053461	129053461	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129053461A>G	uc004euz.2	+	8	776	c.748A>G	c.(748-750)AAA>GAA	p.K250E	UTP14A_uc011mup.1_Missense_Mutation_p.K198E|UTP14A_uc011muq.1_Missense_Mutation_p.K196E|UTP14A_uc004eva.1_5'Flank	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	250	Potential.				rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2																		---	---	---	---
BCORL1	63035	broad.mit.edu	37	X	129189907	129189907	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129189907G>A	uc004evb.1	+	13	5046	c.4932G>A	c.(4930-4932)CCG>CCA	p.P1644P	BCORL1_uc004evc.1_Silent_p.P480P	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1644					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7																		---	---	---	---
ELF4	2000	broad.mit.edu	37	X	129205039	129205039	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129205039T>C	uc004evd.3	-	7	1170	c.785A>G	c.(784-786)TAT>TGT	p.Y262C	ELF4_uc004eve.3_Missense_Mutation_p.Y262C	NM_001421	NP_001412	Q99607	ELF4_HUMAN	E74-like factor 4	262	ETS.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1								T	ERG	AML								---	---	---	---
RBMX2	51634	broad.mit.edu	37	X	129546413	129546413	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129546413C>T	uc004evt.2	+	6	624	c.560C>T	c.(559-561)TCG>TTG	p.S187L		NM_016024	NP_057108	Q9Y388	RBMX2_HUMAN	RNA binding motif protein, X-linked 2	187	Lys-rich.						nucleotide binding|RNA binding			breast(3)|ovary(1)	4																		---	---	---	---
RAP2C	57826	broad.mit.edu	37	X	131348328	131348328	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:131348328A>T	uc004ewp.2	-	3	1204	c.420T>A	c.(418-420)TGT>TGA	p.C140*	RAP2C_uc004ewo.2_Nonsense_Mutation_p.C74*|RAP2C_uc010nrk.2_RNA|RAP2C_uc004ewq.3_Nonsense_Mutation_p.C140*	NM_021183	NP_067006	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family precursor	140					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MBNL3	55796	broad.mit.edu	37	X	131526165	131526165	+	Intron	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:131526165A>G	uc004ewv.3	-						uc004ewr.1_Intron|MBNL3_uc004eww.2_Intron|MBNL3_uc004ews.2_Intron|MBNL3_uc004ewt.2_Intron|MBNL3_uc011muz.1_Intron|MBNL3_uc004ewu.3_Intron|MBNL3_uc004ewx.1_Intron	NM_018388	NP_060858			muscleblind-like 3 isoform G						mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
CCDC160	347475	broad.mit.edu	37	X	133379180	133379180	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133379180A>G	uc011mvj.1	+	2	671	c.350A>G	c.(349-351)AAC>AGC	p.N117S		NM_001101357	NP_001094827	A6NGH7	CC160_HUMAN	coiled-coil domain containing 160	117										skin(1)	1																		---	---	---	---
FHL1	2273	broad.mit.edu	37	X	135288752	135288752	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135288752C>T	uc004ezo.2	+						FHL1_uc010nrz.2_Intron|FHL1_uc004ezm.2_Intron|FHL1_uc004ezl.2_Intron|FHL1_uc004ezq.2_Intron|FHL1_uc011mvy.1_Intron|FHL1_uc011mvz.1_Intron|FHL1_uc004ezn.2_Intron|FHL1_uc011mwa.1_Intron|FHL1_uc011mwb.1_Intron|FHL1_uc004ezp.2_Intron|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174			four and a half LIM domains 1 isoform 1						cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ARHGEF6	9459	broad.mit.edu	37	X	135825784	135825784	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135825784G>A	uc004fab.2	-	5	1083	c.621C>T	c.(619-621)GGC>GGT	p.G207G	ARHGEF6_uc011mwd.1_Silent_p.G53G|ARHGEF6_uc011mwe.1_Silent_p.G53G	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	207	SH3.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ATP11C	286410	broad.mit.edu	37	X	138878614	138878614	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138878614T>C	uc004faz.2	-	12	1132	c.1033A>G	c.(1033-1035)ACC>GCC	p.T345A	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.T345A	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	345	Extracellular (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAGEC3	139081	broad.mit.edu	37	X	140983059	140983059	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140983059G>A	uc011mwp.1	+	5	914	c.914G>A	c.(913-915)TGG>TAG	p.W305*	MAGEC3_uc004fbs.2_5'UTR|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	305	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
SPANXN3	139067	broad.mit.edu	37	X	142596675	142596675	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:142596675T>C	uc004fbw.2	-	2	483	c.395A>G	c.(394-396)GAA>GGA	p.E132G		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	132										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
SLITRK2	84631	broad.mit.edu	37	X	144903977	144903977	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:144903977A>G	uc004fcd.2	+	5	1024	c.34A>G	c.(34-36)ACC>GCC	p.T12A	SLITRK2_uc010nsp.2_Missense_Mutation_p.T12A|SLITRK2_uc010nso.2_Missense_Mutation_p.T12A|SLITRK2_uc011mwq.1_Missense_Mutation_p.T12A|SLITRK2_uc011mwr.1_Missense_Mutation_p.T12A|SLITRK2_uc011mws.1_Missense_Mutation_p.T12A|SLITRK2_uc004fcg.2_Missense_Mutation_p.T12A|SLITRK2_uc011mwt.1_Missense_Mutation_p.T12A	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	12						integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MIR513A2	574510	broad.mit.edu	37	X	146307346	146307346	+	RNA	SNP	A	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:146307346A>T	hsa-mir-513a-2|MI0003192	-			c.125A>T																				0																		---	---	---	---
MIR508	574513	broad.mit.edu	37	X	146318550	146318550	+	5'Flank	SNP	T	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:146318550T>A	hsa-mir-508|MI0003195	-																							0																		---	---	---	---
FMR1NB	158521	broad.mit.edu	37	X	147106430	147106430	+	Silent	SNP	G	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147106430G>T	uc004fcm.2	+	5	752	c.678G>T	c.(676-678)ACG>ACT	p.T226T		NM_152578	NP_689791	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	226	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
AFF2	2334	broad.mit.edu	37	X	147924950	147924950	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147924950T>C	uc004fcp.2	+	7	1734	c.1255T>C	c.(1255-1257)TTC>CTC	p.F419L	AFF2_uc004fco.2_Intron|AFF2_uc004fcq.2_Intron|AFF2_uc004fcr.2_Intron|AFF2_uc011mxb.1_Intron|AFF2_uc004fcs.2_Missense_Mutation_p.F386L|AFF2_uc011mxc.1_Missense_Mutation_p.F60L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	419					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
AFF2	2334	broad.mit.edu	37	X	148037624	148037624	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148037624A>G	uc004fcp.2	+	11	2528	c.2049A>G	c.(2047-2049)GAA>GAG	p.E683E	AFF2_uc004fcq.2_Silent_p.E673E|AFF2_uc004fcr.2_Silent_p.E644E|AFF2_uc011mxb.1_Silent_p.E648E|AFF2_uc004fcs.2_Silent_p.E650E|AFF2_uc011mxc.1_Silent_p.E324E	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	683					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150844591	150844591	+	Silent	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150844591A>G	uc004fev.3	+	16	2630	c.2298A>G	c.(2296-2298)CAA>CAG	p.Q766Q		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	766						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PRRG3	79057	broad.mit.edu	37	X	150869406	150869406	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150869406G>A	uc004few.1	+	4	987	c.597G>A	c.(595-597)GCG>GCA	p.A199A		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	199	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PRRG3	79057	broad.mit.edu	37	X	150869501	150869501	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150869501A>G	uc004few.1	+	4	1082	c.692A>G	c.(691-693)AAG>AGG	p.K231R		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	231	Cytoplasmic (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GABRQ	55879	broad.mit.edu	37	X	151806730	151806730	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151806730A>G	uc004ffp.1	+	1	94	c.74A>G	c.(73-75)TAC>TGC	p.Y25C		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	25	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ZNF275	10838	broad.mit.edu	37	X	152613253	152613253	+	3'UTR	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152613253C>T	uc004fhg.1	+	5					ZNF275_uc011mym.1_Silent_p.I370I|ZNF275_uc011myn.1_Silent_p.I307I					SubName: Full=cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275; SubName: Full=Putative uncharacterized protein ZNF275;							intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ATP2B3	492	broad.mit.edu	37	X	152813387	152813387	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152813387C>T	uc004fht.1	+	7	1179	c.1053C>T	c.(1051-1053)AAC>AAT	p.N351N	ATP2B3_uc004fhs.1_Silent_p.N351N	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	351	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PLXNB3	5365	broad.mit.edu	37	X	153043053	153043053	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153043053C>A	uc004fii.2	+	31	5345	c.5171C>A	c.(5170-5172)GCC>GAC	p.A1724D	PLXNB3_uc010nuk.2_Missense_Mutation_p.A1747D|PLXNB3_uc011mzd.1_Missense_Mutation_p.A1363D|SRPK3_uc004fik.2_5'UTR	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	1724	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
L1CAM	3897	broad.mit.edu	37	X	153128921	153128921	+	Intron	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153128921C>T	uc004fjb.2	-						L1CAM_uc004fjc.2_Intron|L1CAM_uc010nuo.2_Intron	NM_000425	NP_000416			L1 cell adhesion molecule isoform 1 precursor						axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
HCFC1	3054	broad.mit.edu	37	X	153225269	153225269	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153225269G>A	uc004fjp.2	-	8	1956	c.1428C>T	c.(1426-1428)ACC>ACT	p.T476T		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	476					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
TKTL1	8277	broad.mit.edu	37	X	153549268	153549268	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153549268T>C	uc004fkg.2	+						TKTL1_uc011mzl.1_Intron|TKTL1_uc011mzm.1_Intron|TKTL1_uc004fkh.2_Intron	NM_012253	NP_036385			transketolase-like 1 isoform a						glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
TKTL1	8277	broad.mit.edu	37	X	153557991	153557991	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153557991A>G	uc004fkg.2	+	13	1930	c.1744A>G	c.(1744-1746)AGT>GGT	p.S582G	TKTL1_uc011mzl.1_Missense_Mutation_p.S576G|TKTL1_uc011mzm.1_Missense_Mutation_p.S378G|TKTL1_uc004fkh.2_Missense_Mutation_p.S526G	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	582					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153578115	153578115	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153578115A>G	uc004fkk.2	-	46	7703	c.7454T>C	c.(7453-7455)GTC>GCC	p.V2485A	FLNA_uc004fki.2_Missense_Mutation_p.V525A|FLNA_uc011mzn.1_Missense_Mutation_p.V618A|FLNA_uc010nuu.1_Missense_Mutation_p.V2477A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2485	Filamin 23.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)															OREG0003592	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153588878	153588878	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153588878G>A	uc004fkk.2	-	22	3534	c.3285C>T	c.(3283-3285)GCC>GCT	p.A1095A	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Silent_p.A1095A	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1095	Filamin 9.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)															OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153593012	153593012	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153593012T>C	uc004fkk.2	-	13	2153	c.1904A>G	c.(1903-1905)TAC>TGC	p.Y635C	FLNA_uc010nuu.1_Missense_Mutation_p.Y635C	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	635	Filamin 4.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
FLNA	2316	broad.mit.edu	37	X	153594737	153594737	+	Silent	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153594737G>A	uc004fkk.2	-	8	1416	c.1167C>T	c.(1165-1167)CCC>CCT	p.P389P	FLNA_uc010nuu.1_Silent_p.P389P	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	389	Filamin 2.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
FAM50A	9130	broad.mit.edu	37	X	153674214	153674214	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153674214G>A	uc004fll.3	+	3	349	c.251G>A	c.(250-252)CGG>CAG	p.R84Q		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	84					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
PLXNA3	55558	broad.mit.edu	37	X	153688930	153688930	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153688930A>G	uc004flm.2	+	2	580	c.407A>G	c.(406-408)CAC>CGC	p.H136R		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	136	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
GAB3	139716	broad.mit.edu	37	X	153906491	153906491	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153906491T>C	uc004fmj.1	-	10	1773	c.1725A>G	c.(1723-1725)AAA>AAG	p.K575K	GAB3_uc004fmk.1_Silent_p.K576K|GAB3_uc010nve.1_Silent_p.K537K|GAB3_uc004fml.1_Silent_p.K195K	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	575										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
MPP1	4354	broad.mit.edu	37	X	154007457	154007457	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154007457A>G	uc004fmp.1	-	12	1511	c.1396T>C	c.(1396-1398)TAC>CAC	p.Y466H	MPP1_uc010nvg.1_Missense_Mutation_p.Y446H|MPP1_uc011mzv.1_Missense_Mutation_p.Y436H|MPP1_uc004fmq.1_Missense_Mutation_p.Y420H|MPP1_uc011mzw.1_Missense_Mutation_p.Y449H	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	466	Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
F8	2157	broad.mit.edu	37	X	154130394	154130394	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154130394C>T	uc004fmt.2	-	19	6218	c.6047G>A	c.(6046-6048)CGG>CAG	p.R2016Q	F8_uc010nvi.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2016	F5/8 type A 3.|Plastocyanin-like 6.		R -> P (in HEMA; severe familial).|R -> W (in HEMA; severe/moderate/mild).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)													---	---	---	---
F8	2157	broad.mit.edu	37	X	154158195	154158195	+	Silent	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154158195T>C	uc004fmt.2	-	14	4041	c.3870A>G	c.(3868-3870)AAA>AAG	p.K1290K		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1290	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)													---	---	---	---
TMLHE	55217	broad.mit.edu	37	X	154736552	154736552	+	Intron	SNP	T	C	C			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154736552T>C	uc004fnn.2	-						TMLHE_uc004fno.2_Intron|TMLHE_uc004fnp.3_Intron	NM_018196	NP_060666			trimethyllysine hydroxylase, epsilon						carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
TMLHE	55217	broad.mit.edu	37	X	154741369	154741369	+	Silent	SNP	C	T	T			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154741369C>T	uc004fnn.2	-	5	889	c.723G>A	c.(721-723)CGG>CGA	p.R241R	TMLHE_uc004fno.2_Silent_p.R241R|TMLHE_uc004fnp.3_Silent_p.R241R	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	241					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
SPRY3	10251	broad.mit.edu	37	X	155003541	155003541	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-5721-01A-11D-1600-08	TCGA-CG-5721-11A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:155003541C>A	uc004fnq.1	+	2	462	c.8C>A	c.(7-9)GCT>GAT	p.A3D	SPRY3_uc010nvl.1_Missense_Mutation_p.A3D	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	3					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)																	---	---	---	---
