Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR157	80045	broad.mit.edu	37	1	9164555	9164555	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:9164555G>A	uc001apq.1	-	4	1074	c.931C>T	c.(931-933)CCC>TCC	p.P311S	GPR157_uc010oad.1_Missense_Mutation_p.P246S	NM_024980	NP_079256	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		GGAGCCTTGGGAGTGCCAGCC	0.597000													5	32					0	0	0.001984	0	0
CLSTN1	22883	broad.mit.edu	37	1	9815340	9815340	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:9815340C>T	uc001aqh.2	-	4	1031	c.272G>A	c.(271-273)GGG>GAG	p.G91E	CLSTN1_uc001aqi.2_Missense_Mutation_p.G81E|CLSTN1_uc010oag.1_Missense_Mutation_p.G91E	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		GACATTCTGCCCGTGAATTTT	0.473000													22	96					0	0	0.012319	0	0
DFFA	1676	broad.mit.edu	37	1	10523174	10523174	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:10523174G>A	uc001arj.2	-	5	822	c.724C>T	c.(724-726)CTT>TTT	p.L242F	DFFA_uc001ark.2_Missense_Mutation_p.L242F	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	242					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGTGCAGTAAGGATGTGGCTC	0.562000													8	39					0	0	0.008291	0	0
PLOD1	5351	broad.mit.edu	37	1	12010498	12010498	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:12010498G>A	uc001atm.2	+	4	478	c.387G>A	c.(385-387)GAG>GAA	p.E129E	PLOD1_uc010obb.1_Silent_p.E176E	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	129					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCTCTGCTGAGGAGCTCATCT	0.632000													9	47					0	0	0.004482	0	0
SLC25A34	284723	broad.mit.edu	37	1	16065802	16065802	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:16065802C>T	uc001axb.1	+	5	988	c.816C>T	c.(814-816)GGC>GGT	p.G272G	SLC25A34_uc009vok.1_RNA	NM_207348	NP_997231	Q6PIV7	S2534_HUMAN	solute carrier family 25, member 34	272	Solcar 3.				transport	integral to membrane|mitochondrial inner membrane					0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCCTGGGCCCCGCCTACC	0.667000													7	65					0	0	0.003080	0	0
SPEN	23013	broad.mit.edu	37	1	16257865	16257865	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:16257865A>C	uc001axk.1	+	11	5334	c.5130A>C	c.(5128-5130)AAA>AAC	p.K1710N	SPEN_uc010obp.1_Missense_Mutation_p.K1669N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1710					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACCCCGATAAAGAAGCTGCCA	0.582000													35	124					0	0	0.012213	0	0
ALPL	249	broad.mit.edu	37	1	21887134	21887134	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:21887134C>T	uc001bet.2	+	3	334	c.77C>T	c.(76-78)CCC>CTC	p.P26L	ALPL_uc010odn.1_5'UTR|ALPL_uc010odo.1_5'UTR|ALPL_uc010odp.1_5'UTR|ALPL_uc001beu.3_Missense_Mutation_p.P26L	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	26					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GAGAAAGACCCCAAGTACTGG	0.502000													12	57					0	0	0.013537	0	0
CNR2	1269	broad.mit.edu	37	1	24201331	24201331	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:24201331G>A	uc001bif.2	-	2	904	c.777C>T	c.(775-777)TTC>TTT	p.F259F		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	259	Helical; Name=6; (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	CCAGCACTGGGAACCAACAGA	0.587000													5	25					0	0	0.014758	0	0
SH3BGRL3	83442	broad.mit.edu	37	1	26607295	26607295	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:26607295G>A	uc001blu.2	+	2	522	c.88G>A	c.(88-90)GGG>AGG	p.G30R		NM_031286	NP_112576	Q9H299	SH3L3_HUMAN	SH3 domain binding glutamic acid-rich protein	30	Glutaredoxin.				cell redox homeostasis	cytoplasm|nucleus	electron carrier activity|protein disulfide oxidoreductase activity				0		all_cancers(24;1.16e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.22e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00751)|READ - Rectum adenocarcinoma(331;0.0649)		AATCCTGGATGGGAAGCGCAT	0.592000													20	34					0	0	0.007413	0	0
C1orf172	126695	broad.mit.edu	37	1	27278613	27278613	+	Missense_Mutation	SNP	G	A	A	rs145915640		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:27278613G>A	uc001bni.1	-	2	348	c.259C>T	c.(259-261)CGG>TGG	p.R87W		NM_152365	NP_689578	Q8NAX2	CA172_HUMAN	hypothetical protein LOC126695	87	Cys-rich.									large_intestine(1)|ovary(1)	2		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		AAGGCAGCCCGGCACCACTCC	0.662000													9	23					0	0	0.004482	0	0
CSMD2	114784	broad.mit.edu	37	1	34049314	34049314	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:34049314C>T	uc001bxn.1	-	48	7203	c.7174G>A	c.(7174-7176)GAC>AAC	p.D2392N	CSMD2_uc001bxm.1_Missense_Mutation_p.D2390N	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2392	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATGTTATAGTCGGGCTCCACT	0.502000													28	78					0	0	0.027356	0	0
DLGAP3	58512	broad.mit.edu	37	1	35365833	35365833	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:35365833C>T	uc001byc.2	-	2	1149	c.1149G>A	c.(1147-1149)AAG>AAA	p.K383K		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	383					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TCTCCCCATCCTTGCCACCGG	0.607000													18	79					0	0	0.010504	0	0
TFAP2E	339488	broad.mit.edu	37	1	36060083	36060083	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:36060083G>A	uc010ohy.1	+	7	1343	c.1135G>A	c.(1135-1137)GTA>ATA	p.V379I	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	379	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGAGCCCGGAGTACAGAGCTG	0.587000													6	49					0	0	0.021553	0	0
RAD54L	8438	broad.mit.edu	37	1	46726410	46726410	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:46726410C>T	uc009vye.2	+	8	603	c.489C>T	c.(487-489)TTC>TTT	p.F163F	RAD54L_uc001cpl.2_Silent_p.F163F|RAD54L_uc001cpm.1_5'UTR	NM_001142548	NP_001136020	Q92698	RAD54_HUMAN	RAD54-like protein	163					meiosis	nucleus	ATP binding|DNA binding|helicase activity			ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		GAGTGAAATTCCTGTGGGAGT	0.562000								Direct_reversal_of_damage|Homologous_recombination					6	37					0	0	0.001984	0	0
CYP4A11	1579	broad.mit.edu	37	1	47395846	47395846	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:47395846C>T	uc001cqp.3	-	12	1552	c.1501G>A	c.(1501-1503)GGA>AGA	p.G501R		NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	501			NGIHLRLRRLPNPCEDKDQL -> MESTCVSGGSLTLVKTR TSFEGLHLPSCLPDPRFCPLPVCPYPVFCLPTFPSSHLPAV PQSACPSLSHLSPGLPTCLSTCLLPTCISCWEKS (in CYP4A11V).		long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	AGGTGGATTCCATTTTTGGAT	0.483000													8	44					0	0	0.003080	0	0
LRRC7	57554	broad.mit.edu	37	1	70477588	70477588	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:70477588C>T	uc001dep.2	+	10	1029	c.999C>T	c.(997-999)TTC>TTT	p.F333F	LRRC7_uc009wbg.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	333	LRR 14.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ATGAGAATTTCCTTCCAGAAT	0.328000													4	32					0	0	0.009096	0	0
C1orf173	127254	broad.mit.edu	37	1	75038211	75038211	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:75038211C>T	uc001dgg.2	-	14	3402	c.3183G>A	c.(3181-3183)AGG>AGA	p.R1061R		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1061	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TCTCAGCTTTCCTTCGCTCTC	0.428000													37	105					0	0	0.017118	0	0
MIR554	693139	broad.mit.edu	37	1	151518339	151518339	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:151518339C>T	hsa-mir-554|MI0003559	+			c.68C>T			TUFT1_uc001eyl.2_Intron|TUFT1_uc001eym.2_Intron|TUFT1_uc010pdf.1_Intron|TUFT1_uc010pdg.1_Intron																	0						GGTCAGGGTTCATATTTTGGC	0.483000													5	8					0	0	0.021553	0	0
FLG2	388698	broad.mit.edu	37	1	152326903	152326903	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:152326903G>A	uc001ezw.3	-	3	3432	c.3359C>T	c.(3358-3360)TCG>TTG	p.S1120L	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1120	Ser-rich.|Filaggrin 4.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTGAGCCCGATCCATATTG	0.507000													43	160					0	0	0.014410	0	0
S100A9	6280	broad.mit.edu	37	1	153330865	153330865	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:153330865G>A	uc001fbq.2	+	2	149	c.106G>A	c.(106-108)GAA>AAA	p.E36K		NM_002965	NP_002956	P06702	S10A9_HUMAN	S100 calcium-binding protein A9	36	EF-hand 1.|1; low affinity.			E->Q: Loss of resistance to bacterial invasion; when associated with Q-78.	cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAACCAGGGGGAATTCAAAGA	0.517000													4	32					0	0	0.014758	0	0
FCRL1	115350	broad.mit.edu	37	1	157765931	157765931	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:157765931C>T	uc001frg.2	-	11	1361	c.1248G>A	c.(1246-1248)AGG>AGA	p.R416R	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Silent_p.R415R|FCRL1_uc001fri.2_3'UTR|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	416	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTTTGCTTTCCTCAGCCTGG	0.468000													11	37					0	0	0.013537	0	0
CD1A	909	broad.mit.edu	37	1	158225065	158225065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:158225065G>A	uc001frt.2	+	2	783	c.250G>A	c.(250-252)GAA>AAA	p.E84K		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	84	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GAAGGAACTGGAAACATTATT	0.468000													9	45					0	0	0.006214	0	0
OR10K2	391107	broad.mit.edu	37	1	158390164	158390164	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:158390164G>A	uc010pii.1	-	1	493	c.493C>T	c.(493-495)CAC>TAC	p.H165Y		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AAAGGCAGGTGAAATACCAAG	0.473000													18	59					0	0	0.008871	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576796	158576796	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:158576796G>A	uc010pio.1	+	1	568	c.568G>A	c.(568-570)GGA>AGA	p.G190R		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CCTAGCCTGTGGAGATACAGG	0.493000													22	74					0	0	0.014323	0	0
ATP1A4	480	broad.mit.edu	37	1	160151515	160151515	+	Silent	SNP	G	A	A	rs61734684	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:160151515G>A	uc001fve.3	+	19	3257	c.2778G>A	c.(2776-2778)ACG>ACA	p.T926T	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Silent_p.T429T|ATP1A4_uc001fvh.2_Silent_p.T62T	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	926	Helical; (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CATGCCAAACGGCCTTTTTTG	0.512000													16	58					0	0	0.006122	0	0
FMO2	2327	broad.mit.edu	37	1	171162576	171162576	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:171162576C>T	uc001ghk.1	+	3	352	c.235C>T	c.(235-237)CCA>TCA	p.P79S	FMO2_uc010pmd.1_5'UTR	NM_001460	NP_001451	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2	79					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGAAGATTTTCCAAACTTCCT	0.353000													9	28					0	0	0.008291	0	0
ASTN1	460	broad.mit.edu	37	1	176915160	176915160	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:176915160C>T	uc001glc.2	-	13	2363	c.2151G>A	c.(2149-2151)GAG>GAA	p.E717E	ASTN1_uc001glb.1_Silent_p.E717E|ASTN1_uc001gld.1_Silent_p.E717E|ASTN1_uc009wwx.1_Silent_p.E717E	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	725					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCATGGGAAGCTCCCTGCTTT	0.532000													23	71					0	0	0.014323	0	0
FAM5B	57795	broad.mit.edu	37	1	177249716	177249716	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:177249716C>T	uc001glf.2	+	8	1716	c.1404C>T	c.(1402-1404)CAC>CAT	p.H468H	FAM5B_uc001glg.2_Silent_p.H363H	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	468						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CGTGTGCCCACTGTGCTCCAG	0.642000													4	22					0	0	0.009096	0	0
FAM163A	148753	broad.mit.edu	37	1	179783034	179783034	+	Missense_Mutation	SNP	G	A	A	rs145701153		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:179783034G>A	uc009wxj.2	+	6	673	c.214G>A	c.(214-216)GGC>AGC	p.G72S	FAM163A_uc001gnj.2_Missense_Mutation_p.G72S|FAM163A_uc009wxk.2_Missense_Mutation_p.G72S	NM_173509	NP_775780	Q96GL9	F163A_HUMAN	hypothetical protein LOC148753	72						integral to membrane				ovary(1)	1						AGCCCTGGACGGCAGAGGCAG	0.687000													13	32					0	0	0.016723	0	0
HMCN1	83872	broad.mit.edu	37	1	185834918	185834919	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:185834918_185834919GG>AA	uc001grq.1	+	4	773_774	c.544_545GG>AA	c.(544-546)GGA>AAA	p.G182K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	182	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GACCCATATTGGATATAAAGTC	0.337000													8	33					0	0	0.004672	0	0
FAM5C	339479	broad.mit.edu	37	1	190067595	190067595	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:190067595C>T	uc001gse.1	-	8	2086	c.1854G>A	c.(1852-1854)TGG>TGA	p.W618*	FAM5C_uc010pot.1_Nonsense_Mutation_p.W516*	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	618						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AAAATGTCTTCCATTTGTTCC	0.433000													42	178					0	0	0.014410	0	0
ASPM	259266	broad.mit.edu	37	1	197073833	197073833	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:197073833G>A	uc001gtu.2	-	18	4805	c.4548C>T	c.(4546-4548)ACC>ACT	p.T1516T	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1516					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACTTCTGGATGGTTAGTATGG	0.348000													10	66					0	0	0.016723	0	0
CACNA1S	779	broad.mit.edu	37	1	201047233	201047233	+	Splice_Site	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:201047233C>T	uc001gvv.2	-	11	1621	c.1394_splice	c.e11-1	p.D465_splice		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTGGCAATGTCTGTAGGGTTG	0.597000													9	47					0	0	0.006214	0	0
ESRRG	2104	broad.mit.edu	37	1	216680421	216680421	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:216680421G>A	uc001hkw.1	-	7	1403	c.1237C>T	c.(1237-1239)CGA>TGA	p.R413*	ESRRG_uc001hky.1_Nonsense_Mutation_p.R390*|ESRRG_uc009xdp.1_Nonsense_Mutation_p.R390*|ESRRG_uc001hkz.1_Nonsense_Mutation_p.R351*|ESRRG_uc010puc.1_Nonsense_Mutation_p.R390*|ESRRG_uc001hla.1_Nonsense_Mutation_p.R390*|ESRRG_uc001hlb.1_Nonsense_Mutation_p.R390*|ESRRG_uc010pud.1_Nonsense_Mutation_p.R221*|ESRRG_uc001hlc.1_Nonsense_Mutation_p.R390*|ESRRG_uc001hld.1_Nonsense_Mutation_p.R390*|ESRRG_uc001hkx.1_Nonsense_Mutation_p.R425*|ESRRG_uc009xdo.1_Nonsense_Mutation_p.R390*	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	413					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TTGCCAGCTCGACGAGGGTCT	0.502000													16	50					0	0	0.004990	0	0
EPRS	2058	broad.mit.edu	37	1	220162059	220162059	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:220162059G>A	uc001hly.1	-	19	2918	c.2648C>T	c.(2647-2649)TCG>TTG	p.S883L	EPRS_uc010puf.1_Missense_Mutation_p.S634L|EPRS_uc001hlz.1_Missense_Mutation_p.S890L	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	883	3 X 57 AA approximate repeats.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	GCTTGAATCCGAACTTTGAGA	0.428000													26	65					0	0	0.009535	0	0
LEFTY1	10637	broad.mit.edu	37	1	226074696	226074696	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:226074696C>T	uc001hpo.2	-	4	902	c.832G>A	c.(832-834)GCC>ACC	p.A278T	LEFTY1_uc010pvj.1_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	278					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					CAGTTCTCGGCCCACTTCATC	0.647000													6	24					0	0	0.001984	0	0
WNT9A	7483	broad.mit.edu	37	1	228109609	228109609	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:228109609G>A	uc001hri.2	-	4	796	c.708C>T	c.(706-708)TTC>TTT	p.F236F		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	236					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				CCACCTCATGGAAAGGCGCCA	0.627000													18	59					0	0	0.010504	0	0
CHML	1122	broad.mit.edu	37	1	241799053	241799053	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:241799053G>A	uc001hzd.2	-	1	180	c.16C>T	c.(16-18)CCC>TCC	p.P6S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	6					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AACTCTGTGGGAAGATTGTCC	0.433000													14	55					0	0	0.020292	0	0
CNST	163882	broad.mit.edu	37	1	246810636	246810637	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:246810636_246810637CC>TT	uc001ibp.2	+	9	1511_1512	c.1133_1134CC>TT	c.(1132-1134)TCC>TTT	p.S378F	CNST_uc001ibo.3_Missense_Mutation_p.S378F	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	378					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						ACCCAGTCCTCCGAGACAGCAG	0.589000											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	84					0	0	0.004672	0	0
OR2L2	26246	broad.mit.edu	37	1	248201574	248201574	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:248201574A>T	uc001idw.2	+	1	101	c.5A>T	c.(4-6)GAA>GTA	p.E2V	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	2	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTCCCCATGGAAAATTACAAT	0.289000													14	61					0	0	0.020292	0	0
OR2M5	127059	broad.mit.edu	37	1	248308755	248308755	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:248308755C>T	uc010pze.1	+	1	306	c.306C>T	c.(304-306)TTC>TTT	p.F102F		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CACAAATTTTCTTCTATGTAT	0.458000													52	252					0	0	0.014410	0	0
OR14C36	127066	broad.mit.edu	37	1	248512160	248512160	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:248512160C>T	uc010pzl.1	+	1	84	c.84C>T	c.(82-84)TCC>TCT	p.S28S		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATTCTGCATCCTTCTTTATGT	0.443000													23	75					0	0	0.014323	0	0
C10orf18	54906	broad.mit.edu	37	10	5791587	5791587	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:5791587C>T	uc001iij.2	+	15	6828	c.6203C>T	c.(6202-6204)TCT>TTT	p.S2068F	C10orf18_uc001iik.2_Missense_Mutation_p.S912F	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2068										ovary(1)|central_nervous_system(1)	2						AGCTCTTCCTCTTGGAGAGAG	0.473000													9	38					0	0	0.004482	0	0
CUBN	8029	broad.mit.edu	37	10	17026170	17026170	+	Nonsense_Mutation	SNP	G	A	A	rs145661597		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:17026170G>A	uc001ioo.2	-	30	4511	c.4459C>T	c.(4459-4461)CGA>TGA	p.R1487*		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1487	CUB 9.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTCTTGAATCGAATTGCTAGC	0.498000													17	89					0	0	0.004990	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834786	24834786	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:24834786G>A	uc001iru.3	+	21	5768	c.5365G>A	c.(5365-5367)GAC>AAC	p.D1789N	KIAA1217_uc001irs.2_Missense_Mutation_p.D1110N|KIAA1217_uc001irt.3_Missense_Mutation_p.D1155N|KIAA1217_uc010qcy.1_Missense_Mutation_p.D1220N|KIAA1217_uc010qcz.1_Missense_Mutation_p.D1195N|KIAA1217_uc001irw.2_3'UTR|KIAA1217_uc001irz.2_3'UTR|KIAA1217_uc001irx.2_3'UTR|KIAA1217_uc001iry.2_3'UTR	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1789					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						ATCTGGTGGGGACTTTAAGCC	0.507000													16	80					0	0	0.007413	0	0
MPP7	143098	broad.mit.edu	37	10	28408587	28408587	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:28408587C>T	uc001iua.1	-	13	1349	c.945G>A	c.(943-945)AGG>AGA	p.R315R	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.R315R|MPP7_uc009xla.2_Silent_p.R315R|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	315					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TACATGATTTCCTGTTGGAAA	0.398000													24	88					0	0	0.007291	0	0
CXCL12	6387	broad.mit.edu	37	10	44880421	44880421	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:44880421G>A	uc001jbf.2	-	1	122	c.33C>T	c.(31-33)CTC>CTT	p.L11L	CXCL12_uc001jbh.2_Silent_p.L11L|CXCL12_uc001jbi.2_Silent_p.L11L	NM_000609	NP_000600	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12 (stromal	11					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity				0					Dexamethasone(DB01234)	CGGTCAGCACGAGGACCAGCA	0.632000													5	10					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	10	49219553	49219553	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:49219553G>A	uc001jgd.2	-	8	745	c.586C>T	c.(586-588)CCC>TCC	p.P196S						RecName: Full=Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 11; AltName: Full=Centaurin-gamma-like protein KIAA1975;																		TTGGCAGTGGGAGGAACACTG	0.517000													36	149					0	0	0.027894	0	0
CHAT	1103	broad.mit.edu	37	10	50833529	50833529	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:50833529C>T	uc001jhz.2	+	6	916	c.763C>T	c.(763-765)CCC>TCC	p.P255S	CHAT_uc001jhv.1_Missense_Mutation_p.P137S|CHAT_uc001jhx.1_Missense_Mutation_p.P137S|CHAT_uc001jhy.1_Missense_Mutation_p.P137S|CHAT_uc001jia.2_Missense_Mutation_p.P137S|CHAT_uc010qgs.1_Missense_Mutation_p.P137S	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	255					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CCACTCCATTCCCACTGACTG	0.572000													7	22					0	0	0.004482	0	0
PCDH15	65217	broad.mit.edu	37	10	55569273	55569273	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:55569273C>T	uc010qhs.1	-	37	4947	c.4552G>A	c.(4552-4554)GAA>AAA	p.E1518K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qht.1_Missense_Mutation_p.E1511K|PCDH15_uc010qhu.1_Silent_p.L1529L	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TCTCTAATTTCAACCTTTGGT	0.403000										HNSCC(58;0.16)			24	137					0	0	0.006320	0	0
BICC1	80114	broad.mit.edu	37	10	60549603	60549603	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:60549603C>T	uc001jki.1	+	8	957	c.957C>T	c.(955-957)CAC>CAT	p.H319H		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	319	KH 2.				multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						CTCAGATCCACTTTCCTGATC	0.443000													11	67					0	0	0.008291	0	0
ANK3	288	broad.mit.edu	37	10	61829367	61829367	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:61829367C>T	uc001jky.2	-	37	11464	c.11272G>A	c.(11272-11274)GAA>AAA	p.E3758K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3758					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTATAGTTTCATTTTCTAAT	0.378000													24	118					0	0	0.016522	0	0
HK1	3098	broad.mit.edu	37	10	71103614	71103614	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:71103614C>T	uc001jpl.3	+	2	196	c.95C>T	c.(94-96)TCC>TTC	p.S32F	HK1_uc009xqc.1_Missense_Mutation_p.P96S|HK1_uc001jpg.3_Missense_Mutation_p.S20F|HK1_uc001jph.3_Missense_Mutation_p.S36F|HK1_uc001jpi.3_Missense_Mutation_p.S36F|HK1_uc001jpj.3_Missense_Mutation_p.S67F|HK1_uc001jpk.3_Missense_Mutation_p.S31F|HK1_uc009xqd.2_5'UTR	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	32	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						ATGCGGCTCTCCGATGAAACT	0.527000													22	88					0	0	0.014323	0	0
UNC5B	219699	broad.mit.edu	37	10	73058914	73058914	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:73058914C>T	uc001jro.2	+	17	3163	c.2718C>T	c.(2716-2718)ATC>ATT	p.I906I	UNC5B_uc001jrp.2_Silent_p.I895I|UNC5B_uc001jrq.1_5'Flank	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	906	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CGGGTGTGATCCTGGACCTCT	0.612000													46	123					0	0	0.014410	0	0
PDE6C	5146	broad.mit.edu	37	10	95399866	95399866	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:95399866G>A	uc001kiu.3	+	12	1660	c.1522G>A	c.(1522-1524)GAA>AAA	p.E508K		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	508					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				AGAACTGTACGAATTCCGCTT	0.423000													18	55					0	0	0.008871	0	0
ANKRD2	26287	broad.mit.edu	37	10	99332524	99332524	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:99332524C>T	uc001knw.2	+	1	269	c.60C>T	c.(58-60)GCC>GCT	p.A20A	ANKRD2_uc009xvu.2_Silent_p.A20A	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	20					muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CCCCCGAGGCCCTGTGGCCTG	0.672000											OREG0020418	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7					0	0	0.014758	0	0
CALHM1	255022	broad.mit.edu	37	10	105218494	105218494	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:105218494G>A	uc001kxe.2	-	1	155	c.15C>T	c.(13-15)TTC>TTT	p.F5F		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	5						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						AGATCATCCGGAACTTGTCCA	0.627000													4	21					0	0	0.009096	0	0
CCDC147	159686	broad.mit.edu	37	10	106152024	106152024	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:106152024G>A	uc001kyh.2	+	10	1533	c.1399G>A	c.(1399-1401)GAA>AAA	p.E467K		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	467	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		AAAAGTTCGTGAAACACAGAT	0.353000													26	74					0	0	0.024334	0	0
ATRNL1	26033	broad.mit.edu	37	10	117221540	117221540	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:117221540G>A	uc001lcg.2	+	22	3798	c.3412G>A	c.(3412-3414)GAA>AAA	p.E1138K	ATRNL1_uc010qsm.1_Missense_Mutation_p.E267K|ATRNL1_uc010qsn.1_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	1138	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGCAAACCCAGAACAGGTGAG	0.323000													7	40					0	0	0.001984	0	0
TACC2	10579	broad.mit.edu	37	10	123844641	123844641	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:123844641C>T	uc001lfv.2	+	4	2986	c.2626C>T	c.(2626-2628)CAT>TAT	p.H876Y	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.H876Y|TACC2_uc010qtv.1_Missense_Mutation_p.H876Y	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	876						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTCCCAAATCCATGTACCTGT	0.517000													12	33					0	0	0.013537	0	0
GPR26	2849	broad.mit.edu	37	10	125434339	125434339	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:125434339G>A	uc001lhh.2	+	2	727	c.674G>A	c.(673-675)CGG>CAG	p.R225Q		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	225	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				TGCAGTGTGCGGGAACGCTGT	0.552000													7	26					0	0	0.001984	0	0
MKI67	4288	broad.mit.edu	37	10	129906764	129906764	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:129906764G>A	uc001lke.2	-	13	3535	c.3340C>T	c.(3340-3342)CCC>TCC	p.P1114S	MKI67_uc001lkf.2_Missense_Mutation_p.P754S|MKI67_uc009yav.1_Missense_Mutation_p.P689S|MKI67_uc009yaw.1_Missense_Mutation_p.P264S	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1114	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTCAGAGGGACCTGGTGTC	0.498000													50	158					0	0	0.014410	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135098965	135098965	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr10:135098965G>A	uc001lmg.1	-	12	2247	c.1890C>T	c.(1888-1890)ATC>ATT	p.I630I	TUBGCP2_uc001lmf.1_Silent_p.I223I|TUBGCP2_uc010qvc.1_Silent_p.I658I|TUBGCP2_uc009ybk.1_Intron|TUBGCP2_uc010qvd.1_Silent_p.I500I|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	630					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CGCACCTGTTGATGATGAGCG	0.637000													10	34					0	0	0.008291	0	0
PRKCDBP	112464	broad.mit.edu	37	11	6340713	6340713	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:6340713C>T	uc001mcu.1	-	2	500	c.466G>A	c.(466-468)GAG>AAG	p.E156K		NM_145040	NP_659477	Q969G5	PRDBP_HUMAN	protein kinase C, delta binding protein	156											0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCAGCTGCTCTGGGCCCAGC	0.672000													5	11					0	0	0.014758	0	0
MRVI1	10335	broad.mit.edu	37	11	10647629	10647629	+	Missense_Mutation	SNP	C	T	T	rs11604405		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:10647629C>T	uc010rcc.1	-	9	1638	c.1252G>A	c.(1252-1254)GAA>AAA	p.E418K	MRVI1_uc001miw.2_Missense_Mutation_p.E409K|MRVI1_uc010rcb.1_Missense_Mutation_p.E410K|MRVI1_uc009ygb.1_Missense_Mutation_p.E103K|MRVI1_uc001mix.2_Missense_Mutation_p.E103K|MRVI1_uc001miz.2_Missense_Mutation_p.E327K|MRVI1_uc009ygc.1_Missense_Mutation_p.E327K|MRVI1_uc010rcd.1_Intron|MRVI1_uc009ygd.1_Missense_Mutation_p.E103K|MRVI1_uc010rce.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	391					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CGCTTTTCTTCCTCTGCCAGT	0.627000													4	13					0	0	0.009096	0	0
PRMT3	10196	broad.mit.edu	37	11	20414469	20414469	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:20414469C>T	uc001mqb.2	+	5	541	c.324C>T	c.(322-324)TCC>TCT	p.S108S	PRMT3_uc001mqc.2_Silent_p.S31S|PRMT3_uc010rdn.1_Silent_p.S46S	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	108							zinc ion binding				0						ACATGAATTCCATATACAACC	0.318000													24	94					0	0	0.021523	0	0
LUZP2	338645	broad.mit.edu	37	11	24998158	24998158	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:24998158G>A	uc001mqs.2	+	8	778	c.544G>A	c.(544-546)GAA>AAA	p.E182K	LUZP2_uc009yif.2_Missense_Mutation_p.E96K|LUZP2_uc009yig.2_Missense_Mutation_p.E140K	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	182	Potential.|Leucine-zipper.					extracellular region				ovary(1)|skin(1)	2						TACTGATCTGGAACAAAAATT	0.358000													10	20					0	0	0.016723	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137440	40137440	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:40137440G>A	uc001mxa.1	-	2	2367	c.403C>T	c.(403-405)CGT>TGT	p.R135C	LRRC4C_uc001mxc.1_Missense_Mutation_p.R131C|LRRC4C_uc001mxd.1_Missense_Mutation_p.R131C|LRRC4C_uc001mxb.1_Missense_Mutation_p.R131C	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	135	LRR 3.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTAGTAAGACGATTGTCAAAG	0.433000													6	34					0	0	0.001984	0	0
LRP4	4038	broad.mit.edu	37	11	46900680	46900681	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:46900680_46900681GG>AA	uc001ndn.3	-	21	3146_3147	c.3000_3001CC>TT	c.(2998-3003)CCCCCA>CCTTCA	p.P1001S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1001	Extracellular (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TGCTCACCTGGGGGCCGGCGGC	0.614000													19	146					0	0	0.004672	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798066	55798066	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:55798066C>T	uc010riw.1	+	1	172	c.172C>T	c.(172-174)CCC>TCC	p.P58S		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CCTTCAAATTCCCATGTATTA	0.338000													6	33					0	0	0.001984	0	0
OR5T2	219464	broad.mit.edu	37	11	55999895	55999895	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:55999895G>A	uc010rjc.1	-	1	767	c.767C>T	c.(766-768)TCC>TTC	p.S256F		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	256	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					CAAACCATAGGAGATCAGAAC	0.438000													14	56					0	0	0.020292	0	0
TMX2	51075	broad.mit.edu	37	11	57506652	57506652	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:57506652C>T	uc001nlc.1	+	7	713	c.664C>T	c.(664-666)CTG>TTG	p.L222L	CTNND1_uc001nlf.1_Intron|TMX2_uc001nld.1_Silent_p.L128L|TMX2_uc001nle.1_Silent_p.L184L|C11orf31_uc010rjx.1_5'Flank	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	222	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis	integral to membrane					0						TACCCTGATCCTGTTCCAAGG	0.527000													26	68					0	0	0.007291	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947716	57947716	+	Missense_Mutation	SNP	C	T	T	rs142831243		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:57947716C>T	uc001nmj.2	+	3	1116	c.800C>T	c.(799-801)TCG>TTG	p.S267L		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				GATCAGTCTTCGGAGAAGAAT	0.512000													11	74					0	0	0.016723	0	0
MS4A6E	245802	broad.mit.edu	37	11	60105367	60105367	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:60105367G>A	uc001npd.2	+	2	315	c.301G>A	c.(301-303)GAT>AAT	p.D101N		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	101	Extracellular (Potential).					integral to membrane	receptor activity				0						TCTTTCTTATGATTATCATTC	0.403000													20	56					0	0	0.014323	0	0
VWCE	220001	broad.mit.edu	37	11	61032491	61032491	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:61032491C>T	uc001nra.2	-	18	2355	c.2076G>A	c.(2074-2076)AGG>AGA	p.R692R	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	692	VWFC 6.					extracellular region	calcium ion binding			ovary(1)	1						TCGCCACCTTCCTTCCCTCGT	0.662000													9	51					0	0	0.006214	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057818	63057818	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:63057818G>A	uc009yor.2	+	1	389	c.181G>A	c.(181-183)GGT>AGT	p.G61S	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_Missense_Mutation_p.G9S	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	61	Extracellular (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						TACTGGATCTGGTAATGAAAC	0.458000													16	76					0	0	0.024245	0	0
PACS1	55690	broad.mit.edu	37	11	65987269	65987269	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:65987269C>T	uc001oha.1	+	8	1165	c.1031C>T	c.(1030-1032)TCA>TTA	p.S344L		NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	344					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TTTAAAGTTTCAGATGAGGTA	0.488000													11	38					0	0	0.010729	0	0
CABP4	57010	broad.mit.edu	37	11	67223027	67223027	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:67223027G>A	uc001olo.2	+	1	210	c.133G>A	c.(133-135)GAG>AAG	p.E45K	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_Intron	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	45					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GAGCAAGAAGGAGAGGGGGCT	0.647000													7	12					0	0	0.003080	0	0
MFRP	83552	broad.mit.edu	37	11	119217204	119217204	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:119217204A>G	uc001pwj.2	-	1	180	c.20T>C	c.(19-21)GTC>GCC	p.V7A	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.V7A	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GCAGAGGATGACATCTGAGAA	0.567000													3	48					0	0	0.014758	0	0
TECTA	7007	broad.mit.edu	37	11	120984327	120984327	+	Silent	SNP	C	T	T	rs34605023	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:120984327C>T	uc010rzo.1	+	5	690	c.690C>T	c.(688-690)ATC>ATT	p.I230I		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	230	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCCCCGAGATCGTGAATATCC	0.493000													15	23					0	0	0.024245	0	0
KCNJ5	3762	broad.mit.edu	37	11	128782088	128782088	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr11:128782088G>A	uc001qet.2	+	2	1234	c.920G>A	c.(919-921)GGG>GAG	p.G307E	KCNJ5_uc009zck.2_Missense_Mutation_p.G307E|KCNJ5_uc001qew.2_Missense_Mutation_p.G307E	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	307	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	ATTCTAGAAGGGATGGTGGAA	0.517000													14	44					0	0	0.004990	0	0
KDM5A	5927	broad.mit.edu	37	12	459853	459854	+	Missense_Mutation	DNP	GG	AC	AC			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:459853_459854GG>AC	uc001qif.1	-	10	1604_1605	c.1241_1242CC>GT	c.(1240-1242)TCC>TGT	p.S414C	KDM5A_uc001qie.1_Missense_Mutation_p.S414C|KDM5A_uc010sdn.1_Missense_Mutation_p.S373C|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	414					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AGTCTTTTGAGGAGATATCTGC	0.441000			T 	NUP98	AML								13	68					0	0	0.004672	0	0
TSPAN9	10867	broad.mit.edu	37	12	3387672	3387672	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:3387672C>T	uc001qlp.2	+	4	296	c.149C>T	c.(148-150)TCG>TTG	p.S50L		NM_006675	NP_006666	O75954	TSN9_HUMAN	tetraspanin 9	50	Extracellular (Potential).					integral to plasma membrane|membrane fraction				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00153)|COAD - Colon adenocarcinoma(12;0.0831)			AGCTTCCCTTCGTTGTCTGCA	0.592000													16	60					0	0	0.024245	0	0
A2M	2	broad.mit.edu	37	12	9246085	9246085	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:9246085C>T	uc001qvk.1	-	18	2329	c.2216G>A	c.(2215-2217)TGG>TAG	p.W739*	A2M_uc009zgk.1_Nonsense_Mutation_p.W589*	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	739					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATCCCAGATCCATGTCTCAGG	0.458000													5	29					0	0	0.021553	0	0
STYK1	55359	broad.mit.edu	37	12	10772807	10772807	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:10772807T>C	uc001qys.2	-	11	1726	c.1205A>G	c.(1204-1206)GAA>GGA	p.E402G		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	402						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						TGCATACAGTTCAGGTACCAC	0.507000										HNSCC(73;0.22)			39	155					0	0	0.008740	0	0
GRIN2B	2904	broad.mit.edu	37	12	13724791	13724791	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:13724791C>T	uc001rbt.2	-	10	2297	c.2118G>A	c.(2116-2118)ATG>ATA	p.M706I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	706	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGAACTTTCCCATGTAGGCAT	0.478000													17	100					0	0	0.004990	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891723	18891723	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:18891723G>A	uc001rdy.2	+	1	679	c.521G>A	c.(520-522)TGG>TAG	p.W174*	PLCZ1_uc001rdv.3_5'Flank|PLCZ1_uc001rdw.3_5'Flank|PLCZ1_uc010sid.1_5'Flank	NM_033328	NP_201585	Q96KX2	CAZA3_HUMAN	capping protein alpha 3	174					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			ovary(1)|central_nervous_system(1)	2	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				AAATCTAAATGGATTTTCCAA	0.383000													6	40					0	0	0.003080	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21242939	21242939	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:21242939G>A	uc010sil.1	+	16	2211	c.2146G>A	c.(2146-2148)GAT>AAT	p.D716N	LST-3TM12_uc010sim.1_Missense_Mutation_p.D655N|LST-3TM12_uc010sin.1_Missense_Mutation_p.D608N			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	655	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCATGGAAAGGATACCAAAGT	0.343000													7	21					0	0	0.001984	0	0
ABCC9	10060	broad.mit.edu	37	12	21995340	21995340	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:21995340C>T	uc001rfi.1	-	27	3401	c.3381G>A	c.(3379-3381)ATG>ATA	p.M1127I	ABCC9_uc001rfh.2_Missense_Mutation_p.M1127I|ABCC9_uc001rfj.1_Missense_Mutation_p.M1091I	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1127	ABC transmembrane type-1 2.|Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATAAGAAATCATCCCAATGG	0.433000													6	42					0	0	0.004482	0	0
BCAT1	586	broad.mit.edu	37	12	25002810	25002810	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:25002810G>A	uc001rgd.3	-	6	1026	c.584C>T	c.(583-585)TCA>TTA	p.S195L	BCAT1_uc001rgc.2_Missense_Mutation_p.S194L|BCAT1_uc010six.1_Missense_Mutation_p.S207L|BCAT1_uc010siy.1_Missense_Mutation_p.S158L|BCAT1_uc001rge.3_Missense_Mutation_p.S134L	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	195					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	GGTTCCACTTGAAAAATAAGG	0.473000													16	63					0	0	0.028581	0	0
H3F3C	440093	broad.mit.edu	37	12	31944879	31944879	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:31944879G>A	uc001rkr.2	-	1	297	c.222C>T	c.(220-222)ATC>ATT	p.I74I		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	74					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AATCCTGCGCGATCTCCCTCA	0.587000										HNSCC(67;0.2)			8	37					0	0	0.008291	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777753	43777753	+	Nonsense_Mutation	SNP	G	A	A	rs144064003	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:43777753G>A	uc010skx.1	-	30	4480	c.4480C>T	c.(4480-4482)CAG>TAG	p.Q1494*		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1494	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCCCTCTGCTGAACTCCAGAG	0.448000													7	28					0	0	0.003080	0	0
WNT10B	7480	broad.mit.edu	37	12	49360131	49360131	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:49360131C>T	uc001rss.2	-	5	1263	c.917G>A	c.(916-918)GGA>GAA	p.G306E	WNT10B_uc001rst.2_3'UTR	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	306					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						GACCAGCTCTCCTGAGAGGCG	0.637000													18	81					0	0	0.016522	0	0
BCDIN3D	144233	broad.mit.edu	37	12	50232166	50232166	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:50232166G>A	uc001rvh.2	-	2	909	c.867C>T	c.(865-867)TTC>TTT	p.F289F	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_Intron|LOC100286844_uc010smn.1_Intron	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	289							methyltransferase activity			ovary(1)	1						ACTGCTTCTGGAAACTTAATC	0.383000													10	61					0	0	0.020292	0	0
POU6F1	5463	broad.mit.edu	37	12	51584083	51584083	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:51584083G>A	uc001rxy.2	-	5	1045	c.853C>T	c.(853-855)CGG>TGG	p.R285W	POU6F1_uc001rxz.2_Missense_Mutation_p.R285W|POU6F1_uc001rya.2_Missense_Mutation_p.R285W	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	285	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTCTGGCGCCGATTGCAGAAC	0.542000													9	41					0	0	0.004482	0	0
KRT6C	286887	broad.mit.edu	37	12	52865509	52865509	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:52865509C>T	uc001sal.3	-	3	811	c.763G>A	c.(763-765)GAT>AAT	p.D255N		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	255	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		TTGATTTCATCCTCATATCTA	0.428000													20	67					0	0	0.016522	0	0
KRT71	112802	broad.mit.edu	37	12	52941675	52941675	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:52941675C>T	uc001sao.2	-	6	1140	c.1070G>A	c.(1069-1071)AGA>AAA	p.R357K		NM_033448	NP_258259	Q3SY84	K2C71_HUMAN	keratin 71	357	Coil 2.|Rod.						structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.194)		TGAGCGGATTCTCTGGATGAG	0.562000													22	80					0	0	0.014323	0	0
KRT1	3848	broad.mit.edu	37	12	53069058	53069058	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:53069058G>A	uc001sau.1	-	9	1913	c.1854C>T	c.(1852-1854)TCC>TCT	p.S618S	KRT1_uc001sav.1_Silent_p.S611S	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	618	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						CCCCAGAGCTGGATCCCCGGC	0.433000													17	59					0	0	0.006122	0	0
RARG	5916	broad.mit.edu	37	12	53608014	53608014	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:53608014G>A	uc001sce.2	-	7	1127	c.642C>T	c.(640-642)TCC>TCT	p.S214S	RARG_uc001scd.2_Silent_p.S203S|RARG_uc010sob.1_Silent_p.S192S|RARG_uc001scf.2_Silent_p.S214S|RARG_uc001scg.2_Silent_p.S142S|RARG_uc010soc.1_Silent_p.S93S|RARG_uc010sod.1_Silent_p.S251S	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	214	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GGTCTGCACTGGAGTTCTGCA	0.572000													5	51					0	0	0.014758	0	0
OR6C70	390327	broad.mit.edu	37	12	55863664	55863664	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:55863664C>T	uc010spn.1	-	1	259	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATGGTCTTTTCCCTGGTAACA	0.383000													10	36					0	0	0.006214	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872897	57872897	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:57872897G>A	uc001sod.2	-	5	699	c.506C>T	c.(505-507)CCC>CTC	p.P169L	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Missense_Mutation_p.P98L|ARHGAP9_uc001soc.2_Missense_Mutation_p.P98L|ARHGAP9_uc001soe.1_Missense_Mutation_p.P177L|ARHGAP9_uc010sro.1_Missense_Mutation_p.P98L	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	98					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CAATTGGCCGGGGATGACGGT	0.557000													17	79					0	0	0.010504	0	0
BEST3	144453	broad.mit.edu	37	12	70049525	70049525	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:70049525G>A	uc001svg.2	-	10	1396	c.1169C>T	c.(1168-1170)TCC>TTC	p.S390F	BEST3_uc001svd.1_Intron|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Missense_Mutation_p.S177F|BEST3_uc010stm.1_Missense_Mutation_p.S284F	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	390	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TCTTATCATGGAATGCCGATG	0.537000													23	93					0	0	0.006320	0	0
NAV3	89795	broad.mit.edu	37	12	78573380	78573380	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:78573380T>A	uc001syp.2	+	29	5608	c.5435T>A	c.(5434-5436)TTA>TAA	p.L1812*	NAV3_uc001syo.2_Nonsense_Mutation_p.L1790*|NAV3_uc010sub.1_Nonsense_Mutation_p.L1269*|NAV3_uc009zsf.2_Nonsense_Mutation_p.L621*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1812	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GAAAAGGAATTAAAATTAACG	0.473000										HNSCC(70;0.22)			14	64					0	0	0.024245	0	0
ACSS3	79611	broad.mit.edu	37	12	81533033	81533033	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:81533033C>T	uc001szl.1	+	4	860	c.769C>T	c.(769-771)CGT>TGT	p.R257C	ACSS3_uc001szm.1_Missense_Mutation_p.R256C	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	257						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CATTTATAATCGTCCAAATAT	0.328000													5	29					0	0	0.021553	0	0
C12orf50	160419	broad.mit.edu	37	12	88376890	88376890	+	Silent	SNP	C	T	T	rs148724422		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:88376890C>T	uc001tam.1	-	12	1377	c.1209G>A	c.(1207-1209)AAG>AAA	p.K403K		NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	403										skin(2)|ovary(1)	3						CTGGATATATCTTTTCACTTT	0.299000													10	42					0	0	0.006214	0	0
C12orf12	196477	broad.mit.edu	37	12	91347806	91347806	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:91347806G>A	uc001tbj.2	-	1	1148	c.714C>T	c.(712-714)GGC>GGT	p.G238G		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	238										central_nervous_system(1)|pancreas(1)	2						CCTTGCTGCCGCCAGGGGGCG	0.622000													46	138					0	0	0.014410	0	0
DCN	1634	broad.mit.edu	37	12	91539912	91539912	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:91539912G>A	uc001tbs.2	-	7	1097	c.1003C>T	c.(1003-1005)CAG>TAG	p.Q335*	DCN_uc001tbo.2_Nonsense_Mutation_p.Q226*|DCN_uc001tbp.2_Nonsense_Mutation_p.Q188*|DCN_uc001tbq.2_Nonsense_Mutation_p.Q148*|DCN_uc001tbr.2_3'UTR|DCN_uc001tbt.2_Nonsense_Mutation_p.Q335*|DCN_uc001tbu.2_Nonsense_Mutation_p.Q335*	NM_133503	NP_598010	P07585	PGS2_HUMAN	decorin isoform a preproprotein	335	LRR 12.				organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4						TCCCAGTACTGGACCGGGTTG	0.458000													20	32					0	0	0.008871	0	0
ANO4	121601	broad.mit.edu	37	12	101336293	101336293	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:101336293G>A	uc010svm.1	+	5	1008	c.436G>A	c.(436-438)GGA>AGA	p.G146R	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.G111R|ANO4_uc001thx.2_Missense_Mutation_p.G146R	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	146	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						TAGAGCAGAAGGATTGCAAAT	0.353000										HNSCC(74;0.22)			21	63					0	0	0.012319	0	0
PAH	5053	broad.mit.edu	37	12	103245469	103245469	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:103245469G>A	uc001tjq.1	-	9	1380	c.908C>T	c.(907-909)TCC>TTC	p.S303F		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	303			S -> P (in PKU; haplotype 5).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CCTTACCTGGGAAAACTGGGC	0.493000													8	32					0	0	0.006214	0	0
MED13L	23389	broad.mit.edu	37	12	116460261	116460261	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:116460261C>T	uc001tvw.2	-	5	680	c.625G>A	c.(625-627)GTA>ATA	p.V209I		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	209					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCATACTTACCTTGAAATGGT	0.463000													5	25					0	0	0.021553	0	0
GATC	283459	broad.mit.edu	37	12	120884561	120884561	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr12:120884561C>T	uc010szi.1	+	2	183	c.183C>T	c.(181-183)ATC>ATT	p.I61I	TRIAP1_uc001tyg.2_5'Flank	NM_176818	NP_789788	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	61					regulation of translational fidelity						0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGAAAGCTATCGCCTTCGCCG	0.667000													11	34					0	0	0.010729	0	0
LOC284232	284232	broad.mit.edu	37	13	19428948	19428948	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr13:19428948C>T	uc010tcj.1	-	1		c.17162G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TTCTGTTTTCCTTTTCCATGG	0.299000													13	50					0	0	0.008871	0	0
KL	9365	broad.mit.edu	37	13	33628169	33628169	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr13:33628169G>A	uc001uus.2	+	2	1093	c.1085G>A	c.(1084-1086)GGA>GAA	p.G362E	KL_uc001uur.1_Missense_Mutation_p.G55E	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	362	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TTCATCAAAGGAACTGCTGAC	0.413000													24	84					0	0	0.027356	0	0
NHLRC3	387921	broad.mit.edu	37	13	39621917	39621917	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr13:39621917A>T	uc001uxc.2	+	7	1220	c.898A>T	c.(898-900)AGC>TGC	p.S300C	NHLRC3_uc001uxd.2_Missense_Mutation_p.S233C|NHLRC3_uc001uxe.2_Missense_Mutation_p.S103C	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	300	NHL 4.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TTCTGTGATCAGCACAATCCA	0.483000													7	33					0	0	0.001984	0	0
PCDH9	5101	broad.mit.edu	37	13	67801345	67801345	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr13:67801345G>A	uc001vik.2	-	2	1920	c.1228C>T	c.(1228-1230)CAT>TAT	p.H410Y	PCDH9_uc001vil.2_Missense_Mutation_p.H410Y|PCDH9_uc010thl.1_Missense_Mutation_p.H410Y|PCDH9_uc001vin.3_Missense_Mutation_p.H410Y	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	410	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GCCTTCAAATGAAATGGGACC	0.378000													8	29					0	0	0.004482	0	0
COL4A2	1284	broad.mit.edu	37	13	111132648	111132648	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr13:111132648G>A	uc001vqx.2	+	31	2958	c.2669G>A	c.(2668-2670)GGA>GAA	p.G890E		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	890	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGTGACAGAGGAGATGCTGGC	0.572000													12	39					0	0	0.013537	0	0
OR4K2	390431	broad.mit.edu	37	14	20344609	20344609	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:20344609C>T	uc001vwh.1	+	1	183	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTATGTATTTCCTGCTTACCA	0.403000													20	197					0	0	0.016522	0	0
OR4K1	79544	broad.mit.edu	37	14	20404621	20404621	+	Missense_Mutation	SNP	C	T	T	rs147347995		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:20404621C>T	uc001vwj.1	+	1	796	c.796C>T	c.(796-798)CCT>TCT	p.P266S		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P266S(1)		skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TAGCAGACTTCCTGTGGACAA	0.413000													20	92					0	0	0.010504	0	0
OR10G2	26534	broad.mit.edu	37	14	22102464	22102464	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:22102464C>T	uc010tmc.1	-	1	535	c.535G>A	c.(535-537)GTG>ATG	p.V179M		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AAGTAATCCACCTGATTGGGC	0.562000													17	80					0	0	0.008871	0	0
CDH24	64403	broad.mit.edu	37	14	23517499	23517499	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:23517499G>A	uc001wil.2	-	13	2410	c.2150C>T	c.(2149-2151)CCC>CTC	p.P717L	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.P679L	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	717	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		Tcggcgcgcgggagggccggg	0.602000													10	20					0	0	0.006214	0	0
AKAP6	9472	broad.mit.edu	37	14	33201765	33201765	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:33201765G>A	uc001wrq.2	+	10	3276	c.3106G>A	c.(3106-3108)GAA>AAA	p.E1036K	AKAP6_uc010aml.2_Missense_Mutation_p.E1033K	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1036	Spectrin 2.				protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TGATCTCCTTGAAAAAGTGGA	0.373000													18	71					0	0	0.006122	0	0
NIN	51199	broad.mit.edu	37	14	51238084	51238084	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:51238084G>A	uc001wym.2	-	10	1275	c.1084C>T	c.(1084-1086)CTG>TTG	p.L362L	NIN_uc001wyi.2_Silent_p.L362L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.L362L|NIN_uc010tqp.1_Silent_p.L368L|NIN_uc001wyo.2_Silent_p.L362L|NIN_uc001wyp.1_Silent_p.L324L	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	362	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					AAGCTGGCCAGAGCCGCCTGG	0.473000			T	PDGFRB	MPD								11	21					0	0	0.008291	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65209767	65209767	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:65209767C>T	uc001xho.1	+	17	3275	c.3006C>T	c.(3004-3006)CCC>CCT	p.P1002P	PLEKHG3_uc001xhn.1_Silent_p.P946P|PLEKHG3_uc001xhp.2_Silent_p.P1123P|PLEKHG3_uc010aqh.1_Silent_p.P544P|PLEKHG3_uc001xhq.1_Silent_p.P507P	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	1002					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		ACAGCCCTCCCAAGCCCTCCT	0.617000													32	89					0	0	0.009535	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72138058	72138058	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:72138058C>T	uc001xms.2	+	8	2826	c.2478C>T	c.(2476-2478)ATC>ATT	p.I826I	SIPA1L1_uc001xmt.2_Silent_p.I826I|SIPA1L1_uc001xmu.2_Silent_p.I826I|SIPA1L1_uc001xmv.2_Silent_p.I826I|SIPA1L1_uc010ttm.1_Silent_p.I301I	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	826	Rap-GAP.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACACCCCTATCGACCCTTCTG	0.517000													12	40					0	0	0.016723	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72200434	72200434	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:72200434G>A	uc001xms.2	+	19	5324	c.4976G>A	c.(4975-4977)AGG>AAG	p.R1659K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1638K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1638K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1659K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R1113K|SIPA1L1_uc001xmw.2_Missense_Mutation_p.R424K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1659					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAGACCCGCAGGCAGCCTATG	0.597000													12	44					0	0	0.020292	0	0
RGS6	9628	broad.mit.edu	37	14	72818858	72818858	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:72818858G>A	uc001xna.3	+	3	663	c.140G>A	c.(139-141)AGA>AAA	p.R47K	RGS6_uc010ttn.1_Missense_Mutation_p.R47K|RGS6_uc001xmx.3_Missense_Mutation_p.R47K|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.R47K	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	47	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		GTGCCCATCAGAACAGTCAAG	0.418000													4	25					0	0	0.021553	0	0
FLRT2	23768	broad.mit.edu	37	14	86088162	86088162	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:86088162G>A	uc001xvr.2	+	2	1071	c.304G>A	c.(304-306)GAA>AAA	p.E102K	FLRT2_uc010atd.2_Missense_Mutation_p.E102K	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	102	Extracellular (Potential).|LRR 2.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CCAACTGGACGAATTCCCCAT	0.468000													15	64					0	0	0.024245	0	0
KIAA1409	57578	broad.mit.edu	37	14	94069615	94069615	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:94069615A>G	uc001ybv.1	+	23	3157	c.3074A>G	c.(3073-3075)AAC>AGC	p.N1025S	KIAA1409_uc001ybs.1_Missense_Mutation_p.N1025S	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1202						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AATGTTGCTAACCTCAGCGAT	0.478000													35	94					0	0	0.027894	0	0
HHIPL1	84439	broad.mit.edu	37	14	100126712	100126712	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:100126712G>A	uc010avs.2	+	5	1536	c.1471G>A	c.(1471-1473)GGC>AGC	p.G491S	HHIPL1_uc001ygl.1_Missense_Mutation_p.G491S	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	491					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				CAACCTGAACGGCCTCTACAT	0.602000													11	34					0	0	0.016723	0	0
C14orf73	91828	broad.mit.edu	37	14	103566802	103566802	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:103566802C>T	uc001ymk.2	+	1	322	c.246C>T	c.(244-246)TCC>TCT	p.S82S		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	82											0		Melanoma(154;0.155)	Epithelial(46;0.221)			GCTCCTGCTCCCTGTTCCGGT	0.667000													3	21					0	0	0.004672	0	0
EIF5	1983	broad.mit.edu	37	14	103802236	103802236	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:103802236C>T	uc001ymq.2	+	3	561	c.39C>T	c.(37-39)TTC>TTT	p.F13F	EIF5_uc001ymr.2_Silent_p.F13F|EIF5_uc001yms.2_Silent_p.F13F|EIF5_uc001ymt.2_Silent_p.F13F|EIF5_uc001ymu.2_Silent_p.F13F|SNORA28_uc001ymv.1_5'Flank	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	13					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			CAGACCAGTTCTATCGCTACA	0.378000													21	76					0	0	0.024334	0	0
ADAM6	8755	broad.mit.edu	37	14	106109851	106109851	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:106109851C>T	uc010tyt.1	-	3643		c.61303G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						ACCTGTGGTTCTCGGGGCTGC	0.652000													8	164					0	0	0.016723	0	0
ADAM6	8755	broad.mit.edu	37	14	106208121	106208121	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:106208121C>T	uc010tyt.1	-	3628		c.58996G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Missense_Mutation_p.E94K|uc001ysf.2_Missense_Mutation_p.E94K					Parts of antibodies, mostly variable regions.												0						ACCTGTGGTTCTCGGGGCTGC	0.647000													15	94					0	0	0.028581	0	0
ADAM6	8755	broad.mit.edu	37	14	106511873	106511873	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:106511873C>T	uc010tyt.1	-	1673		c.33515G>A								Parts of antibodies, mostly variable regions.												0						AATGGTGAATCGGCCCTTCAC	0.512000													9	26					0	0	0.010729	0	0
ADAM6	8755	broad.mit.edu	37	14	107078514	107078514	+	RNA	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:107078514G>A	uc010tyt.1	-	117		c.5776C>T								Parts of antibodies, mostly variable regions.												0						TGCCAACGACGATCCATCCTA	0.522000													8	46					0	0	0.004482	0	0
ADAM6	8755	broad.mit.edu	37	14	107083558	107083558	+	Splice_Site	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr14:107083558C>T	uc010tyt.1	-	113		c.5236_splice	c.e113-1							Parts of antibodies, mostly variable regions.												0						GACAGGACCCCTGTGAACAGA	0.612000													6	39					0	0	0.008291	0	0
TRIM69	140691	broad.mit.edu	37	15	45059759	45059759	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:45059759C>T	uc001zuf.2	+	8	2187	c.1292C>T	c.(1291-1293)TCT>TTT	p.S431F	TRIM69_uc001zui.1_Missense_Mutation_p.S227F|TRIM69_uc010bdy.1_Missense_Mutation_p.S210F|TRIM69_uc001zug.1_Missense_Mutation_p.S431F|TRIM69_uc001zuh.1_Missense_Mutation_p.S272F	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	431	B30.2/SPRY.				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		GATTTGCCTTCTTTCAGTCTG	0.453000													15	44					0	0	0.024245	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49293101	49293101	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:49293101G>A	uc001zxe.1	-	15	2355	c.2221C>T	c.(2221-2223)CCA>TCA	p.P741S	SECISBP2L_uc001zxd.1_Missense_Mutation_p.P696S|SECISBP2L_uc010bep.1_Missense_Mutation_p.P503S	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	741										breast(1)|skin(1)	2						TCACAGTTTGGAGAAATTATA	0.358000													6	41					0	0	0.001984	0	0
GNB5	10681	broad.mit.edu	37	15	52416676	52416676	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:52416676G>A	uc002abt.1	-	12	1235	c.1170C>T	c.(1168-1170)ACC>ACT	p.T390T	GNB5_uc002abr.1_Silent_p.T348T|GNB5_uc002abs.1_Silent_p.T278T	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	390	WD 7.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		TTACTCTGAGGGTATGATCCC	0.522000													12	33					0	0	0.010729	0	0
UNC13C	440279	broad.mit.edu	37	15	54542546	54542546	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:54542546C>T	uc002ack.2	+	6	3352	c.3352C>T	c.(3352-3354)CTG>TTG	p.L1118L		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1118	Phorbol-ester/DAG-type.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGAAGGGCTCCTGTGGGGCAT	0.517000													12	45					0	0	0.024245	0	0
CCNB2	9133	broad.mit.edu	37	15	59408902	59408902	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:59408902C>T	uc002afz.2	+	6	759	c.611C>T	c.(610-612)TCC>TTC	p.S204F	CCNB2_uc010bge.2_Missense_Mutation_p.S123F	NM_004701	NP_004692	O95067	CCNB2_HUMAN	cyclin B2	204					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding				0						CAGCCAGTTTCCCGGAAGAAG	0.408000													8	36					0	0	0.006214	0	0
GCNT3	9245	broad.mit.edu	37	15	59910848	59910848	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:59910848G>A	uc002age.2	+	3	860	c.411G>A	c.(409-411)ATG>ATA	p.M137I	GCNT3_uc002agd.2_Missense_Mutation_p.M137I	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	137	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						CATACTCTATGGTGATTCATG	0.458000													11	59					0	0	0.016723	0	0
PARP16	54956	broad.mit.edu	37	15	65553305	65553305	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:65553305G>A	uc002aoo.2	-	5	1005	c.751C>T	c.(751-753)CCT>TCT	p.P251S	PARP16_uc002aop.2_Missense_Mutation_p.P136S|PARP16_uc002aoq.2_Missense_Mutation_p.P251S	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	251	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						TACTTGGGAGGGATGTCTCCC	0.483000													18	84					0	0	0.006122	0	0
C15orf60	283677	broad.mit.edu	37	15	73852092	73852092	+	Splice_Site	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:73852092G>A	uc002avq.2	+	6	665	c.637_splice	c.e6-1	p.T213_splice	C15orf60_uc010bjb.2_Splice_Site_p.T185_splice	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677											pancreas(1)	1						TATCCCTGCAGACTCTTCTGG	0.453000													11	53					0	0	0.013537	0	0
CHRNA5	1138	broad.mit.edu	37	15	78882972	78882972	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:78882972C>T	uc002bdy.2	+	5	1401	c.1239C>T	c.(1237-1239)GTC>GTT	p.V413V	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	413	Cytoplasmic (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAATGATGTCCGTGAGGTCT	0.388000													5	20					0	0	0.014758	0	0
MCTP2	55784	broad.mit.edu	37	15	95001366	95001366	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr15:95001366G>A	uc002btj.2	+	19	2316	c.2251G>A	c.(2251-2253)GAA>AAA	p.E751K	MCTP2_uc010boj.2_Missense_Mutation_p.E480K|MCTP2_uc010bok.2_Missense_Mutation_p.E696K|MCTP2_uc002btl.2_Missense_Mutation_p.E339K	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	751					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TGTTTTCTAGGAATCTGAGAA	0.299000													4	41					0	0	0.014758	0	0
PDIA2	64714	broad.mit.edu	37	16	333347	333348	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:333347_333348CC>TT	uc002cgn.1	+	6	1286_1287	c.178_179CC>TT	c.(178-180)CCT>TTT	p.P60F	PDIA2_uc010bqt.1_5'UTR|PDIA2_uc002cgo.1_Missense_Mutation_p.P60F	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	60	Thioredoxin 1.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCGGGAGCACCCTGCCCTGCTG	0.703000													9	33					0	0	0.004672	0	0
PIGQ	9091	broad.mit.edu	37	16	624430	624430	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:624430G>A	uc002cho.2	+	2	458	c.356G>A	c.(355-357)GGT>GAT	p.G119D	PIGQ_uc010bqw.2_Missense_Mutation_p.G119D|PIGQ_uc002chm.2_Missense_Mutation_p.G119D|PIGQ_uc002chn.2_Missense_Mutation_p.G119D|PIGQ_uc010uui.1_Missense_Mutation_p.G133D	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	119					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				ACTGCCCCCGGTGCCCCTGGT	0.682000													4	20					0	0	0.014758	0	0
CASKIN1	57524	broad.mit.edu	37	16	2231002	2231002	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:2231002C>T	uc010bsg.1	-	18	2399	c.2367G>A	c.(2365-2367)CAG>CAA	p.Q789Q		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	789	Pro-rich.				signal transduction	cytoplasm				skin(2)	2						CCCCAAGGGCCTGGGGAGAGC	0.711000													4	22					0	0	0.009096	0	0
CREBBP	1387	broad.mit.edu	37	16	3808895	3808895	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:3808895G>C	uc002cvv.2	-	17	3533	c.3329C>G	c.(3328-3330)CCT>CGT	p.P1110R	CREBBP_uc002cvw.2_Missense_Mutation_p.P1072R	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1110	Bromo.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CTGCCGGAAAGGTAATGACTC	0.453000			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				15	44					0	0	0.020292	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857481	9857481	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:9857481G>A	uc002czo.3	-	13	4468	c.3920C>T	c.(3919-3921)CCC>CTC	p.P1307L	GRIN2A_uc010uym.1_Missense_Mutation_p.P1307L|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1307	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCTCCGGGAGGGCCTGCTAAG	0.483000													26	89					0	0	0.006320	0	0
ACSM2A	123876	broad.mit.edu	37	16	20471599	20471599	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:20471599G>A	uc010bwe.2	+	3	402	c.163G>A	c.(163-165)GCT>ACT	p.A55T	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Intron|ACSM2A_uc002dhf.3_Missense_Mutation_p.A55T|ACSM2A_uc002dhg.3_Missense_Mutation_p.A55T|ACSM2A_uc010vay.1_Intron	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	55					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GGATCACTGGGCTGACATGGA	0.398000													7	15					0	0	0.003080	0	0
ACSM1	116285	broad.mit.edu	37	16	20635437	20635437	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:20635437G>A	uc002dhm.1	-	12	1696	c.1628C>T	c.(1627-1629)CCA>CTA	p.P543L	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Missense_Mutation_p.P543L	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	543					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						GTACTTGTATGGGGCTGTCAC	0.468000													38	103					0	0	0.027894	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203689	23203689	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:23203689C>A	uc002dlm.1	+	4	774	c.635C>A	c.(634-636)TCC>TAC	p.S212Y		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	212	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	AATGACACCTCCGACTGTGCC	0.498000													32	66					2.20474e-14	2.85919e-14	0.017118	1	0
PLK1	5347	broad.mit.edu	37	16	23700596	23700596	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:23700596C>T	uc002dlz.1	+	8	1361	c.1308C>T	c.(1306-1308)TTC>TTT	p.F436F		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	436	POLO box 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		GGGTGCTCTTCAATGACTCAA	0.517000													11	54					0	0	0.013537	0	0
CHP2	63928	broad.mit.edu	37	16	23768611	23768611	+	Silent	SNP	G	A	A	rs150633217	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:23768611G>A	uc002dmb.1	+	6	927	c.504G>A	c.(502-504)GGG>GGA	p.G168G		NM_022097	NP_071380	O43745	CHP2_HUMAN	hepatocellular carcinoma antigen gene 520	168	2 (Potential).|EF-hand 4.						calcium ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(48;0.0144)		ATGAAGATGGGGATGGGGCTG	0.567000													4	27					0	0	0.009096	0	0
IL4R	3566	broad.mit.edu	37	16	27373776	27373776	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:27373776C>G	uc002don.2	+	11	1345	c.1103C>G	c.(1102-1104)CCG>CGG	p.P368R	IL4R_uc002dop.3_Missense_Mutation_p.P353R|IL4R_uc010bxy.2_Missense_Mutation_p.P368R|IL4R_uc002doo.2_Missense_Mutation_p.P208R	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	368	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TTTGAGGCCCCGGTGGAGTGT	0.582000													13	32					0	0	0.013537	0	0
GTF3C1	2975	broad.mit.edu	37	16	27495610	27495610	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:27495610G>A	uc002dov.1	-	25	3963	c.3923C>T	c.(3922-3924)TCT>TTT	p.S1308F	GTF3C1_uc002dou.2_Missense_Mutation_p.S1308F	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1308						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TTTATCCAAAGACTCTTCAAA	0.468000													11	44					0	0	0.008291	0	0
XPO6	23214	broad.mit.edu	37	16	28118943	28118943	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:28118943G>A	uc002dpa.1	-	18	2898	c.2397C>T	c.(2395-2397)ATC>ATT	p.I799I	XPO6_uc002dpb.1_Silent_p.I785I|XPO6_uc010vcp.1_Silent_p.I799I	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	799					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						ACTCCCCCGAGATATTCTCCA	0.483000													12	71					0	0	0.024245	0	0
XPO6	23214	broad.mit.edu	37	16	28123301	28123301	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:28123301G>A	uc002dpa.1	-	17	2679	c.2178C>T	c.(2176-2178)CTC>CTT	p.L726L	XPO6_uc002dpb.1_Silent_p.L712L|XPO6_uc010vcp.1_Silent_p.L726L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	726					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						AGATGTTAGAGAGGGCTCGGC	0.592000													3	8					0	0	0.009096	0	0
ZNF267	10308	broad.mit.edu	37	16	31926985	31926985	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:31926985C>T	uc002ecs.3	+	4	1624	c.1415C>T	c.(1414-1416)TCT>TTT	p.S472F		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	472	C2H2-type 6.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						TGTAGCAAATCTTATGCTCGT	0.348000													16	53					0	0	0.028581	0	0
UBE2MP1	606551	broad.mit.edu	37	16	34404346	34404346	+	RNA	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:34404346G>A	uc002edv.1	-	1		c.417C>T				NR_002837				full-length cDNA clone CS0DH003YB23 of T cells (Jurkat cell line) of Homo sapiens (human).												0						ACCTTGGGGGGATCATGCGGG	0.507000													6	33					0	0	0.021553	0	0
PHKB	5257	broad.mit.edu	37	16	47630348	47630348	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:47630348C>T	uc002eev.3	+	13	1321	c.1269C>T	c.(1267-1269)AAC>AAT	p.N423N	PHKB_uc002eeu.3_Silent_p.N416N	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	423					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				AAAAAAATAACCCTGGTAGTC	0.353000													17	65					0	0	0.028581	0	0
IRX5	10265	broad.mit.edu	37	16	54967405	54967405	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:54967405C>T	uc002ehv.2	+	3	1072	c.1072C>T	c.(1072-1074)CCA>TCA	p.P358S	IRX5_uc002ehw.2_Missense_Mutation_p.P292S	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	358					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						CGAGGGCTCTCCATGCCCACC	0.716000													5	20					0	0	0.003080	0	0
VAC14	55697	broad.mit.edu	37	16	70765459	70765459	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:70765459G>A	uc002ezm.2	-	14	1858	c.1600C>T	c.(1600-1602)CTT>TTT	p.L534F	VAC14_uc010cfw.2_Missense_Mutation_p.L300F|VAC14_uc002ezn.2_Missense_Mutation_p.L99F|VAC14_uc002ezl.2_5'UTR|VAC14_uc010cfx.1_Missense_Mutation_p.L12F	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	534					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				CTCTTGAGAAGGTTGATCATG	0.488000													16	59					0	0	0.024245	0	0
HYDIN	54768	broad.mit.edu	37	16	70896038	70896038	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:70896038C>T	uc002ezr.2	-	69	11815	c.11687G>A	c.(11686-11688)GGA>GAA	p.G3896E	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3897										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CGGCACGATTCCCGAAGAGGG	0.542000													5	13					0	0	0.014758	0	0
HYDIN	54768	broad.mit.edu	37	16	71007790	71007790	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:71007790G>A	uc002ezr.2	-	34	5296	c.5168C>T	c.(5167-5169)TCC>TTC	p.S1723F		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1724										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GAGATGATTGGAAAGCTGAAT	0.493000													9	81					0	0	0.006214	0	0
CALB2	794	broad.mit.edu	37	16	71406132	71406132	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:71406132G>A	uc002faa.3	+	2	241	c.171G>A	c.(169-171)ATG>ATA	p.M57I	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Missense_Mutation_p.M57I	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	57							calcium ion binding				0		Ovarian(137;0.125)				GCTCTGGCATGGTAAGCCCAG	0.453000													6	46					0	0	0.021553	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76572122	76572122	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:76572122G>A	uc002feu.1	+	21	3490	c.3105G>A	c.(3103-3105)ATG>ATA	p.M1035I	CNTNAP4_uc002fev.1_Missense_Mutation_p.M899I|CNTNAP4_uc010chb.1_Missense_Mutation_p.M962I|CNTNAP4_uc002fex.1_Missense_Mutation_p.M1038I	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1035	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						ATGGTGATATGAAGCTGAGCA	0.373000													10	61					0	0	0.013537	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353748	77353748	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:77353748C>T	uc002ffc.3	-	16	2949	c.2530G>A	c.(2530-2532)GAA>AAA	p.E844K	ADAMTS18_uc010chc.1_Missense_Mutation_p.E432K|ADAMTS18_uc002ffe.1_Missense_Mutation_p.E540K	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	844	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGGCTTACTTCAAAGACCAGC	0.507000													14	43					0	0	0.020292	0	0
ANKRD11	29123	broad.mit.edu	37	16	89350631	89350632	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:89350631_89350632GG>AA	uc002fmx.1	-	9	2779_2780	c.2318_2319CC>TT	c.(2317-2319)CCC>CTT	p.P773L	ANKRD11_uc002fmy.1_Missense_Mutation_p.P773L|ANKRD11_uc002fnc.1_Missense_Mutation_p.P773L|ANKRD11_uc002fnb.1_Missense_Mutation_p.P730L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	773	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTAATTTTGAGGGCCGGTCTTT	0.332000													7	39					0	0	0.004672	0	0
C16orf7	9605	broad.mit.edu	37	16	89776226	89776226	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr16:89776226G>A	uc002fom.1	-	11	1472	c.1347C>T	c.(1345-1347)CCC>CCT	p.P449P	C16orf7_uc002fol.1_Silent_p.P379P|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	449					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGGAGAAAAAGGGTTCCTCAA	0.607000													15	93					0	0	0.004990	0	0
SPATA22	84690	broad.mit.edu	37	17	3349852	3349852	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:3349852G>A	uc002fvm.2	-	7	953	c.716C>T	c.(715-717)TCT>TTT	p.S239F	SPATA22_uc010vrg.1_Missense_Mutation_p.S223F|SPATA22_uc010vrf.1_Missense_Mutation_p.S239F|SPATA22_uc002fvn.2_Missense_Mutation_p.S239F|SPATA22_uc002fvo.2_Missense_Mutation_p.S239F|SPATA22_uc002fvp.2_Missense_Mutation_p.S239F|SPATA22_uc010ckf.2_Missense_Mutation_p.S196F	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	239											0						AATTCTTAAAGAACTAGCTTT	0.279000													3	18					0	0	0.004672	0	0
P2RX5	5026	broad.mit.edu	37	17	3593961	3593961	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:3593961G>A	uc002fwi.2	-	4	658	c.374C>T	c.(373-375)CCT>CTT	p.P125L	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.P125L|P2RX5_uc010vrx.1_Missense_Mutation_p.P65L|P2RX5_uc002fwj.2_Missense_Mutation_p.P101L|P2RX5_uc002fwk.2_Missense_Mutation_p.P125L|P2RX5_uc002fwl.2_Missense_Mutation_p.P101L|P2RX5_uc002fwm.1_Missense_Mutation_p.P125L	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	125	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						CGCGCCATCAGGAATGCCTTC	0.632000													8	41					0	0	0.004482	0	0
ATP2A3	489	broad.mit.edu	37	17	3839604	3839605	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:3839604_3839605GG>AA	uc002fxb.1	-	16	2631_2632	c.2480_2481CC>TT	c.(2479-2481)GCC>GTT	p.A827V	ATP2A3_uc002fwx.1_Missense_Mutation_p.A827V|ATP2A3_uc002fwy.1_Missense_Mutation_p.A827V|ATP2A3_uc002fwz.1_Missense_Mutation_p.A827V|ATP2A3_uc002fxa.1_Missense_Mutation_p.A827V|ATP2A3_uc002fxc.1_Missense_Mutation_p.A827V|ATP2A3_uc002fxd.1_Missense_Mutation_p.A827V	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	827	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CACTGATGAGGGCTTCTCGGGG	0.604000													13	58					0	0	0.004672	0	0
NLRP1	22861	broad.mit.edu	37	17	5461840	5461840	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:5461840G>A	uc002gci.2	-	4	2731	c.2176C>T	c.(2176-2178)CGG>TGG	p.R726W	NLRP1_uc002gcg.1_Missense_Mutation_p.R726W|NLRP1_uc002gck.2_Missense_Mutation_p.R726W|NLRP1_uc002gcj.2_Missense_Mutation_p.R726W|NLRP1_uc002gcl.2_Missense_Mutation_p.R726W|NLRP1_uc002gch.3_Missense_Mutation_p.R726W|NLRP1_uc010clh.2_Missense_Mutation_p.R726W	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	726					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GTTTTGTTCCGAGTCTCGTAC	0.537000													13	54					0	0	0.013537	0	0
FBXO39	162517	broad.mit.edu	37	17	6683581	6683581	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:6683581C>T	uc010vtg.1	+	2	514	c.394C>T	c.(394-396)CAA>TAA	p.Q132*		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	132										ovary(1)|skin(1)	2						TCTTTCCATCCAATACCTGGA	0.502000													8	45					0	0	0.003080	0	0
ZBTB4	57659	broad.mit.edu	37	17	7369559	7369559	+	Missense_Mutation	SNP	G	A	A	rs17854296		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:7369559G>A	uc002ghc.3	-	3	812	c.562C>T	c.(562-564)CCT>TCT	p.P188S	ZBTB4_uc002ghd.3_Missense_Mutation_p.P188S	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	188				P -> S (in Ref. 6; AAH43352).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		GCTGGGGTAGGAGGTACCCAG	0.692000													9	28					0	0	0.004482	0	0
AURKB	9212	broad.mit.edu	37	17	8110589	8110589	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:8110589G>A	uc002gkm.2	-	5	364	c.303C>T	c.(301-303)TTC>TTT	p.F101F	AURKB_uc010cnu.2_5'UTR|AURKB_uc002gkn.2_Silent_p.F102F|AURKB_uc010vuu.1_Silent_p.F60F|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	101	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						GCGCCACGATGAAATGGCTTT	0.537000													11	19					0	0	0.008291	0	0
MYH4	4622	broad.mit.edu	37	17	10358064	10358064	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:10358064C>T	uc002gmn.2	-	22	2610	c.2499G>A	c.(2497-2499)TGG>TGA	p.W833*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	833					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ACAGCTTCATCCAGGGCCAGT	0.428000													12	67					0	0	0.010729	0	0
TAOK1	57551	broad.mit.edu	37	17	27825354	27825354	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:27825354G>T	uc002hdz.1	+	12	1212	c.1018G>T	c.(1018-1020)GGC>TGC	p.G340C	TAOK1_uc010wbe.1_Missense_Mutation_p.G340C|TAOK1_uc010wbf.1_Missense_Mutation_p.G340C|TAOK1_uc002heb.1_Missense_Mutation_p.G166C	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	340					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TCATGGTGTTGGCCGGACAGG	0.403000													13	65					2.32078e-09	3.00337e-09	0.024245	1	0
KRT31	3881	broad.mit.edu	37	17	39550407	39550407	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:39550407G>A	uc002hwn.2	-	7	1165	c.1112C>T	c.(1111-1113)CCC>CTC	p.P371L	KRT31_uc010cxn.2_3'UTR	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	371	Tail.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				CGTGGCACAGGGATTGCTGGG	0.532000													14	58					0	0	0.004990	0	0
KRT37	8688	broad.mit.edu	37	17	39577662	39577662	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:39577662C>T	uc002hwp.1	-	6	1245	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	uc002hwo.1_Intron	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	400	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GTGGCAATCTCGTTCTCCAAC	0.557000													12	47					0	0	0.013537	0	0
KRT13	3860	broad.mit.edu	37	17	39661582	39661582	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:39661582C>T	uc002hwu.1	-	1	284	c.221G>A	c.(220-222)GGA>GAA	p.G74E	KRT13_uc002hwv.1_Missense_Mutation_p.G74E|KRT13_uc002hww.2_Intron|KRT13_uc010wfr.1_Intron|KRT13_uc010cxo.2_Missense_Mutation_p.G74E|KRT13_uc002hwx.1_Intron	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	74	Gly-rich.|Head.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				aaggccacctccatagccacc	0.179000													5	13					0	0	0.014758	0	0
KIF2B	84643	broad.mit.edu	37	17	51900733	51900733	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:51900733G>A	uc002iua.2	+	1	495	c.339G>A	c.(337-339)ACG>ACA	p.T113T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	113					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GTACCGCCACGAAATGGGTTG	0.592000													16	68					0	0	0.028581	0	0
MPO	4353	broad.mit.edu	37	17	56351017	56351017	+	Missense_Mutation	SNP	C	T	T	rs149133270	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:56351017C>T	uc002ivu.1	-	9	1556	c.1379G>A	c.(1378-1380)CGG>CAG	p.R460Q		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	460					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CAGGTAGTCCCGGTAAGTGAT	0.587000													11	83					0	0	0.010729	0	0
CDC42EP4	23580	broad.mit.edu	37	17	71282105	71282105	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:71282105G>A	uc002jjn.2	-	2	682	c.535C>T	c.(535-537)CTC>TTC	p.L179F	CDC42EP4_uc002jjo.2_Missense_Mutation_p.L179F|CDC42EP4_uc002jjp.1_Missense_Mutation_p.L109F	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	179					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			TGCTCATCGAGGAGGGGGTCA	0.652000													11	42					0	0	0.008291	0	0
SDK2	54549	broad.mit.edu	37	17	71357857	71357857	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:71357857C>T	uc010dfm.2	-	39	5433	c.5433G>A	c.(5431-5433)GAG>GAA	p.E1811E	SDK2_uc002jjt.3_Silent_p.E951E|SDK2_uc010dfn.2_Silent_p.E1490E	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1811	Extracellular (Potential).|Fibronectin type-III 12.				cell adhesion	integral to membrane				ovary(2)	2						TGGCTTCGATCTCCGGCCCGT	0.637000													12	35					0	0	0.020292	0	0
GALK1	2584	broad.mit.edu	37	17	73758813	73758813	+	Silent	SNP	G	A	A	rs146095595		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:73758813G>A	uc010wsi.1	-	5	828	c.765C>T	c.(763-765)CTC>CTT	p.L255L	GALK1_uc002jpk.2_Silent_p.L255L|GALK1_uc010wsj.1_3'UTR	NM_000154	NP_000145	P51570	GALK1_HUMAN	galactokinase 1	255					galactose catabolic process	cytosol	ATP binding|galactokinase activity|galactose binding				0	all_cancers(13;1.5e-07)		all cancers(21;1.03e-06)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTACCTCCCGGAGGCTTTCCT	0.637000													9	48					0	0	0.008291	0	0
UNK	85451	broad.mit.edu	37	17	73818610	73818610	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:73818610C>T	uc002jpm.2	+	15	2118	c.2118C>T	c.(2116-2118)TTC>TTT	p.F706F		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	630							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGGAAGCTTCTCCCCGGGCA	0.612000													18	90					0	0	0.012319	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74622103	74622103	+	Missense_Mutation	SNP	C	T	T	rs151127625		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:74622103C>T	uc002jsh.2	-	7	1664	c.1490G>A	c.(1489-1491)CGA>CAA	p.R497Q	ST6GALNAC1_uc002jsi.2_Missense_Mutation_p.R365Q|ST6GALNAC1_uc002jsj.2_RNA	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	sialyltransferase 7A	497	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity				0						CTTCATGTATCGGAGAAAGTC	0.542000													27	111					0	0	0.008361	0	0
SGSH	6448	broad.mit.edu	37	17	78188094	78188095	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr17:78188094_78188095GG>AA	uc002jxz.3	-	5	626_627	c.539_540CC>TT	c.(538-540)CCC>CTT	p.P180L	SGSH_uc002jya.3_5'UTR|SGSH_uc002jxy.2_Missense_Mutation_p.P180L|SGSH_uc010wue.1_Missense_Mutation_p.P192F	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	180					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CACAGCGGTGGGGGTCGTGGAA	0.653000													5	29					0	0	0.004672	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6244485	6244486	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:6244485_6244486CC>TT	uc002kmz.3	-	6	481_482	c.321_322GG>AA	c.(319-324)GCGGAG>GCAAAG	p.E108K	L3MBTL4_uc010dkt.2_Missense_Mutation_p.E108K	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	108	MBT 1.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				CCTCTTACCTCCGCTACAGAAA	0.376000													20	64					0	0	0.004672	0	0
KIAA0802	23255	broad.mit.edu	37	18	8819105	8819105	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:8819105C>T	uc002knr.2	+	13	3146	c.3004C>T	c.(3004-3006)CCG>TCG	p.P1002S	KIAA0802_uc002knq.2_Missense_Mutation_p.P961S|KIAA0802_uc002kns.2_Missense_Mutation_p.P342S	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1312											0						TGACTCCATCCCGTTTGAAGA	0.597000													9	22					0	0	0.006214	0	0
POTEC	388468	broad.mit.edu	37	18	14542741	14542741	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:14542741G>A	uc010dln.2	-	1	859	c.405C>T	c.(403-405)GTC>GTT	p.V135V	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	135										skin(3)	3						CTTCTCGACGGACGTGGTACC	0.602000													26	57					0	0	0.018920	0	0
DSC2	1824	broad.mit.edu	37	18	28648938	28648938	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:28648938C>T	uc002kwl.3	-	15	2884	c.2430G>A	c.(2428-2430)AGG>AGA	p.R810R	DSC2_uc002kwk.3_Silent_p.R810R	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	810	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TGTGTCCTCCCCTGCAGGAGT	0.562000													21	37					0	0	0.014323	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44260065	44260065	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:44260065G>A	uc002lcj.1	-	7	1639	c.1071C>T	c.(1069-1071)TTC>TTT	p.F357F	ST8SIA5_uc002lci.1_Silent_p.F204F|ST8SIA5_uc010xcy.1_Silent_p.F393F|ST8SIA5_uc010xcz.1_Silent_p.F326F	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	357	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GCAAGTGCAGGAAGTTGAAGA	0.642000													17	49					0	0	0.006122	0	0
LIPG	9388	broad.mit.edu	37	18	47108848	47108848	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:47108848G>A	uc002ldv.2	+	7	1405	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K	LIPG_uc010xdh.1_Missense_Mutation_p.E311K	NM_006033	NP_006024	Q9Y5X9	LIPE_HUMAN	endothelial lipase precursor	385	PLAT.				cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			ovary(1)|skin(1)	2						TCTGCCACTGGAAATGTAAGT	0.483000													16	38					0	0	0.004990	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471555	61471555	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr18:61471555C>T	uc002ljl.2	+	8	925	c.829C>T	c.(829-831)CCT>TCT	p.P277S	SERPINB7_uc002ljm.2_Missense_Mutation_p.P277S|SERPINB7_uc010xet.1_Missense_Mutation_p.P260S|SERPINB7_uc010dqg.2_Missense_Mutation_p.P277S	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	277					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				GGTATTTTTTCCTCAGTTCAA	0.353000													10	25					0	0	0.006214	0	0
BSG	682	broad.mit.edu	37	19	580652	580652	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:580652C>T	uc002loz.2	+	5	760	c.662C>T	c.(661-663)CCC>CTC	p.P221L	BSG_uc002loy.2_Missense_Mutation_p.P41L|BSG_uc002lpa.2_Missense_Mutation_p.P105L|BSG_uc002lpb.2_RNA|BSG_uc010drr.2_Missense_Mutation_p.P105L|BSG_uc002lpc.2_Missense_Mutation_p.P268L|BSG_uc002lpd.2_5'Flank	NM_001728	NP_001719	P35613	BASI_HUMAN	basigin isoform 1 precursor	221	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGGGCCTCCCAGAGTGAAG	0.662000													7	22					0	0	0.003080	0	0
C19orf21	126353	broad.mit.edu	37	19	760010	760010	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:760010C>T	uc002lpo.2	+	3	1965	c.1882C>T	c.(1882-1884)CCT>TCT	p.P628S		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	628										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACAGTGCTCCTCCCGGGCA	0.577000													9	26					0	0	0.008291	0	0
C19orf21	126353	broad.mit.edu	37	19	763512	763512	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:763512C>T	uc002lpo.2	+	5	2045	c.1962C>T	c.(1960-1962)GCC>GCT	p.A654A		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	654										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTGGAAGCCATACGGGTGA	0.592000													3	20					0	0	0.004672	0	0
DOT1L	84444	broad.mit.edu	37	19	2199905	2199905	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:2199905C>T	uc002lvb.3	+	8	710	c.674C>T	c.(673-675)TCA>TTA	p.S225L		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	225						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GATTTCCTCTCAGAAGAGTGG	0.647000													10	33					0	0	0.008291	0	0
APBA3	9546	broad.mit.edu	37	19	3760157	3760157	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:3760157G>A	uc002lyp.1	-	2	283	c.106C>T	c.(106-108)CAG>TAG	p.Q36*	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	36					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTCCCACTGGCTGTCAGGG	0.617000													13	33					0	0	0.024245	0	0
ANKRD24	170961	broad.mit.edu	37	19	4216919	4216919	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:4216919G>A	uc010dtt.1	+	18	2038	c.1762G>A	c.(1762-1764)GGA>AGA	p.G588R	ANKRD24_uc002lzs.2_Missense_Mutation_p.G559R|ANKRD24_uc002lzt.2_Missense_Mutation_p.G560R	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	588											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CGAGGCCACGGGAGCTGAGGC	0.542000													5	11					0	0	0.014758	0	0
FBN3	84467	broad.mit.edu	37	19	8159390	8159390	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:8159390C>T	uc002mjf.2	-	46	5866	c.5845G>A	c.(5845-5847)GAG>AAG	p.E1949K		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1949	EGF-like 31; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AAGGAGCCCTCGAGGTTCTGG	0.597000													5	21					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9060909	9060909	+	Missense_Mutation	SNP	G	A	A	rs144604762	by1000genomes	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:9060909G>A	uc002mkp.2	-	3	26741	c.26537C>T	c.(26536-26538)TCA>TTA	p.S8846L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8848	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTTTCCACTGATGGGCGGCT	0.517000													18	80					0	0	0.008871	0	0
MUC16	94025	broad.mit.edu	37	19	9069117	9069117	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:9069117C>T	uc002mkp.2	-	3	18533	c.18329G>A	c.(18328-18330)AGG>AAG	p.R6110K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6112	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTTCTGCCCTGGAGACCTC	0.498000													3	17					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9072272	9072273	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:9072272_9072273GG>AA	uc002mkp.2	-	3	15377_15378	c.15173_15174CC>TT	c.(15172-15174)ACC>ATT	p.T5058I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5060	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTCTGGTAAGGTAGAAGAAAT	0.480000													12	58					0	0	0.004672	0	0
MUC16	94025	broad.mit.edu	37	19	9085554	9085554	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:9085554C>T	uc002mkp.2	-	1	6465	c.6261G>A	c.(6259-6261)ACG>ACA	p.T2087T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2087	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAATTCAGTCGTAGTTGAAC	0.478000													43	147					0	0	0.008740	0	0
OR7E24	26648	broad.mit.edu	37	19	9362115	9362115	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:9362115C>T	uc002mlb.1	+	1	396	c.396C>T	c.(394-396)CTC>CTT	p.L132L		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	132	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATGACATGCTCCTGAGTGTGA	0.478000													12	36					0	0	0.016723	0	0
ICAM4	3386	broad.mit.edu	37	19	10397740	10397740	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:10397740C>T	uc002mns.1	+	1	91	c.52C>T	c.(52-54)CCG>TCG	p.P18S	ICAM4_uc002mnr.1_Missense_Mutation_p.P18S|ICAM4_uc002mnt.1_Missense_Mutation_p.P18S|ICAM5_uc002mnu.3_5'Flank	NM_001544	NP_001535	Q14773	ICAM4_HUMAN	intercellular adhesion molecule 4 isoform 1	18				AAAYPGVGSALGRRTK -> RPPTRELGARWDAGL (in Ref. 1; AAA59538/AAA59537).	cell-cell adhesion|regulation of immune response	extracellular region|integral to membrane|plasma membrane	integrin binding			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GGCCGCCTACCCGGGAGTTGG	0.687000													3	14					0	0	0.009096	0	0
KEAP1	9817	broad.mit.edu	37	19	10610321	10610321	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:10610321G>A	uc002moq.1	-	2	545	c.389C>T	c.(388-390)CCC>CTC	p.P130L	KEAP1_uc002mor.1_Missense_Mutation_p.P130L	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	130	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CATGACCTTGGGGTGGATACC	0.587000													8	35					0	0	0.006214	0	0
ELAVL3	1995	broad.mit.edu	37	19	11569342	11569342	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:11569342C>T	uc002mry.1	-	4	798	c.418G>A	c.(418-420)GAG>AAG	p.E140K	ELAVL3_uc002mrx.1_Missense_Mutation_p.E140K	NM_001420	NP_001411	Q14576	ELAV3_HUMAN	ELAV-like protein 3 isoform 1	140	RRM 2.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3						TGCTCCATCTCTTTCTGGCTC	0.617000													18	82					0	0	0.006122	0	0
ZNF799	90576	broad.mit.edu	37	19	12501407	12501407	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:12501407G>A	uc010dyt.2	-	4	1955	c.1805C>T	c.(1804-1806)TCC>TTC	p.S602F	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	602	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TCTATGCAAGGAACTGAGAGA	0.413000													19	68					0	0	0.027356	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586958	15586959	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:15586958_15586959CC>TT	uc002nbf.3	-	2	655_656	c.522_523GG>AA	c.(520-525)AGGGAT>AGAAAT	p.D175N	PGLYRP2_uc002nbg.3_Missense_Mutation_p.D175N	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	175					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						GGAGAGCCATCCCTGAGTCCTG	0.545000													18	81					0	0	0.004672	0	0
CYP4F12	66002	broad.mit.edu	37	19	15791299	15791299	+	Silent	SNP	G	A	A	rs141478890		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:15791299G>A	uc002nbl.2	+	5	556	c.495G>A	c.(493-495)ACG>ACA	p.T165T	CYP4F12_uc010xoo.1_Silent_p.T165T|CYP4F12_uc010xop.1_3'UTR	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,									p.T165T(1)		skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CCTATATAACGATCTTCAACA	0.493000													8	28					0	0	0.004482	0	0
CPAMD8	27151	broad.mit.edu	37	19	17038839	17038839	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:17038839C>T	uc002nfb.2	-	25	3523	c.3491G>A	c.(3490-3492)CGA>CAA	p.R1164Q		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1117						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGCGGTGGCTCGCTCAGACCC	0.617000													19	54					0	0	0.016522	0	0
PDE4C	5143	broad.mit.edu	37	19	18332977	18332977	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:18332977C>T	uc010xqc.1	-	2	879	c.399G>A	c.(397-399)AAG>AAA	p.K133K	PDE4C_uc002nik.3_Silent_p.K133K|PDE4C_uc002nil.3_Silent_p.K133K|PDE4C_uc002nif.3_5'Flank|PDE4C_uc002nig.3_5'Flank|PDE4C_uc002nih.3_5'Flank|PDE4C_uc010ebk.2_Silent_p.K27K|PDE4C_uc002nii.3_Silent_p.K101K|PDE4C_uc010ebl.2_5'UTR|PDE4C_uc010xqd.1_5'UTR|PDE4C_uc010ebm.1_5'Flank|PDE4C_uc002nim.1_Silent_p.K133K	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	133					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	GAGACATGGCCTTGGGCGAGA	0.617000													4	15					0	0	0.014758	0	0
ELL	8178	broad.mit.edu	37	19	18557592	18557592	+	Missense_Mutation	SNP	G	A	A	rs151228060	byFrequency	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:18557592G>A	uc002njh.2	-	9	1570	c.1498C>T	c.(1498-1500)CCC>TCC	p.P500S	ELL_uc010ebq.2_Missense_Mutation_p.P443S|ELL_uc002njg.2_Missense_Mutation_p.P367S	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	500					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		GTGGACGTGGGAACACTGGAA	0.607000			T	MLL	AL								8	25					0	0	0.004482	0	0
NDUFA13	51079	broad.mit.edu	37	19	19645890	19645890	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:19645890C>T	uc010xqy.1	+	5	871	c.612C>T	c.(610-612)GTC>GTT	p.V204V	NDUFA13_uc010xqx.1_3'UTR|YJEFN3_uc002nmt.1_Silent_p.V122V|YJEFN3_uc010ecf.1_Silent_p.V72V|YJEFN3_uc002nmu.1_RNA	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CGGTGCTGGTCGTGTGTGGCC	0.592000													14	107					0	0	0.028581	0	0
Unknown	0	broad.mit.edu	37	19	22785479	22785479	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:22785479C>T	uc002nqu.3	+	8		c.1568C>T								Homo sapiens cDNA FLJ60031 complete cds, moderately similar to Golgin subfamily A member 2.																		ATCGCTGCATCCAGCTCTCTG	0.602000													15	53					0	0	0.024245	0	0
LOC100101266	100101266	broad.mit.edu	37	19	24345739	24345739	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:24345739C>T	uc010edb.1	-	1		c.511G>A				NR_003603				Homo sapiens hepatitis A virus cellular receptor 1 pseudogene (LOC100101266), non-coding RNA.												0						TTGGAACAGTCTTTGTCGTTG	0.453000													44	181					0	0	0.014410	0	0
SLC7A10	56301	broad.mit.edu	37	19	33701437	33701437	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:33701437C>T	uc002num.2	-	9	1346	c.1199G>A	c.(1198-1200)GGC>GAC	p.G400D	SLC7A10_uc002nul.2_Missense_Mutation_p.G247D	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	400	Helical; (Potential).				blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GATGGTGACGCCGTAGCAGAG	0.647000													8	25					0	0	0.003080	0	0
SLC7A10	56301	broad.mit.edu	37	19	33703819	33703819	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:33703819G>A	uc002num.2	-	3	593	c.446C>T	c.(445-447)CCC>CTC	p.P149L	SLC7A10_uc002nul.2_5'Flank|SLC7A10_uc010xrq.1_Missense_Mutation_p.P122L	NM_019849	NP_062823	Q9NS82	AAA1_HUMAN	solute carrier family 7, member 10	149					blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(110;0.137)					GGGGAACACGGGCTGCAGCAC	0.617000													9	49					0	0	0.004482	0	0
FFAR2	2867	broad.mit.edu	37	19	35940955	35940955	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:35940955C>T	uc002nzg.2	+	2	419	c.339C>T	c.(337-339)TTC>TTT	p.F113F	FFAR2_uc010eea.2_Silent_p.F113F	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	113	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GAGTGGCTTTCCCCGTGCAGT	0.592000													6	31					0	0	0.021553	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36269472	36269473	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:36269472_36269473CC>TT	uc002obr.1	+	5	462_463	c.377_378CC>TT	c.(376-378)CCC>CTT	p.P126L	ARHGAP33_uc002obs.1_Missense_Mutation_p.P126L|ARHGAP33_uc002obt.1_5'UTR|ARHGAP33_uc010eek.1_Missense_Mutation_p.P144L	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	126	PX; atypical.|Poly-Pro.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCGGAGCTTCCCCCGCCCCCCG	0.604000													13	38					0	0	0.004672	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279063	36279063	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:36279063C>T	uc002obs.1	+	21	3198	c.3113C>T	c.(3112-3114)CCC>CTC	p.P1038L	ARHGAP33_uc002obt.1_Missense_Mutation_p.P1035L|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.P787L	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1199					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CGTTCAGATCCCGGTCCCCCA	0.687000													5	27					0	0	0.001984	0	0
ZNF527	84503	broad.mit.edu	37	19	37880104	37880104	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:37880104C>T	uc010efk.1	+	5	1264	c.1153C>T	c.(1153-1155)CCA>TCA	p.P385S	ZNF527_uc002ogf.3_Missense_Mutation_p.P353S|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGTGAGAAACCATATGAATG	0.423000													5	23					0	0	0.021553	0	0
CYP2B6	1555	broad.mit.edu	37	19	41510220	41510220	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:41510220G>A	uc002opr.1	+	3	360	c.353G>A	c.(352-354)GGA>GAA	p.G118E	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.G78E	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	118					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	TTTGCCAATGGAAACCGCTGG	0.552000													9	22					0	0	0.006214	0	0
PSG6	5675	broad.mit.edu	37	19	43411845	43411845	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:43411845C>T	uc002ovj.1	-	4	920	c.868G>A	c.(868-870)GAA>AAA	p.E290K	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.E297K|PSG6_uc002ovi.2_Missense_Mutation_p.E291K|PSG6_uc010xwk.1_Missense_Mutation_p.E130K|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Missense_Mutation_p.E80K|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Missense_Mutation_p.E290K	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	290	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				ATCCTGTTTTCAATGGGTCGC	0.493000													40	167					0	0	0.009718	0	0
PSG9	5678	broad.mit.edu	37	19	43762435	43762435	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:43762435G>A	uc002owd.3	-	5	1261	c.1162C>T	c.(1162-1164)CAT>TAT	p.H388Y	PSG9_uc002owe.3_Missense_Mutation_p.H295Y|PSG9_uc010xwm.1_Missense_Mutation_p.H295Y|PSG9_uc002owf.3_Missense_Mutation_p.H202Y|PSG9_uc002owg.2_Missense_Mutation_p.H295Y|PSG9_uc002owh.2_Missense_Mutation_p.H202Y	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	388	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				AGCCCGCTATGATTTCTAGTA	0.443000													37	49					0	0	0.025465	0	0
ZNF226	7769	broad.mit.edu	37	19	44681407	44681407	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:44681407C>T	uc002oyp.2	+	6	2136	c.1992C>T	c.(1990-1992)GTC>GTT	p.V664V	ZNF226_uc002oyq.2_Silent_p.V547V|ZNF226_uc002oyr.2_Silent_p.V547V|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Silent_p.V664V|ZNF226_uc002oyt.2_Silent_p.V664V	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	664	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				ATCAAAAAGTCCACACTGGAG	0.473000													18	41					0	0	0.006122	0	0
ZC3H4	23211	broad.mit.edu	37	19	47569967	47569967	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:47569967C>T	uc002pga.3	-	15	3596	c.3558G>A	c.(3556-3558)AAG>AAA	p.K1186K	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1186							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		ACGGGGGCTCCTTAGCCTTGG	0.657000													3	15					0	0	0.004672	0	0
MYH14	79784	broad.mit.edu	37	19	50721003	50721003	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:50721003G>A	uc002prr.1	+	3	584	c.537G>A	c.(535-537)GAG>GAA	p.E179E	MYH14_uc010enu.1_Silent_p.E179E|MYH14_uc002prq.1_Silent_p.E179E	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	179	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CAGTGACCGAGGGGGCCTATC	0.647000													22	52					0	0	0.021523	0	0
ZNF320	162967	broad.mit.edu	37	19	53367268	53367268	+	RNA	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:53367268G>A	uc010eqh.1	-	3		c.409C>T			ZNF320_uc010eqi.1_RNA			A2RRD8	ZN320_HUMAN	Homo sapiens full length insert cDNA clone ZD42C02.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTCATGTCTGGAGGAACATTT	0.453000													4	26					0	0	0.014758	0	0
ZNF331	55422	broad.mit.edu	37	19	54080689	54080689	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:54080689T>A	uc002qbx.1	+	7	2309	c.875T>A	c.(874-876)ATT>AAT	p.I292N	ZNF331_uc002qby.1_Missense_Mutation_p.I292N|ZNF331_uc002qbz.1_Missense_Mutation_p.I292N|ZNF331_uc002qca.1_Missense_Mutation_p.I292N|ZNF331_uc010eqr.1_Missense_Mutation_p.I292N|ZNF331_uc002qcb.1_Missense_Mutation_p.I292N|ZNF331_uc002qcc.1_Missense_Mutation_p.I292N|ZNF331_uc002qcd.1_Missense_Mutation_p.I292N	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	292	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		CATAAAAGAATTCACACAGGT	0.433000			T	?	follicular thyroid adenoma								11	26					0	0	0.008291	0	0
LILRB5	10990	broad.mit.edu	37	19	54756349	54756349	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:54756349C>T	uc002qex.2	-	10	1646	c.1535G>A	c.(1534-1536)AGG>AAG	p.R512K	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.R504K|LILRB5_uc002qey.2_Missense_Mutation_p.R513K|LILRB5_uc002qez.2_Missense_Mutation_p.R413K|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	512	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCAGAATTACCTCTTCTGCAG	0.632000													20	67					0	0	0.008871	0	0
NLRP13	126204	broad.mit.edu	37	19	56423937	56423937	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:56423937C>T	uc010ygg.1	-	5	1271	c.1246G>A	c.(1246-1248)GAA>AAA	p.E416K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	416	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AAGAGAGTTTCGTTTTTTCTT	0.463000													12	42					0	0	0.010729	0	0
ZNF418	147686	broad.mit.edu	37	19	58438057	58438057	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr19:58438057G>A	uc002qqs.1	-	4	1784	c.1492C>T	c.(1492-1494)CGT>TGT	p.R498C	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.R413C	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	498	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TGATGAACACGAAACCCAGAG	0.458000													19	77					0	0	0.010504	0	0
ASAP2	8853	broad.mit.edu	37	2	9515056	9515056	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:9515056C>T	uc002qzh.2	+	17	2069	c.1729C>T	c.(1729-1731)CCA>TCA	p.P577S	ASAP2_uc002qzi.2_Missense_Mutation_p.P577S	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	577					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						GGAAAAAATCCCACTGGCCAA	0.343000													18	76					0	0	0.007413	0	0
APOB	338	broad.mit.edu	37	2	21231015	21231015	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:21231015C>T	uc002red.2	-	26	8853	c.8725G>A	c.(8725-8727)GAG>AAG	p.E2909K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2909					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTCTTGATCTCGTTGCGCAGG	0.468000													139	527					0	0	0.014410	0	0
GCKR	2646	broad.mit.edu	37	2	27722055	27722055	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:27722055G>A	uc002rky.2	+	6	541	c.475G>A	c.(475-477)GGG>AGG	p.G159R	GCKR_uc010ezd.2_Missense_Mutation_p.G159R|GCKR_uc010ylu.1_Intron	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	159	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGCCTTGCACGGGATTGAGGA	0.522000													9	47					0	0	0.008291	0	0
GCKR	2646	broad.mit.edu	37	2	27746184	27746184	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:27746184G>A	uc002rky.2	+	19	1822	c.1756G>A	c.(1756-1758)GAG>AAG	p.E586K	GCKR_uc010ezd.2_Missense_Mutation_p.E584K|GCKR_uc010ylu.1_Missense_Mutation_p.E396K	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	586					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					CTCGATCACTGAGGCTCAGGC	0.602000													6	21					0	0	0.021553	0	0
GALNT14	79623	broad.mit.edu	37	2	31135094	31135094	+	Nonsense_Mutation	SNP	G	A	A	rs35447902		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:31135094G>A	uc002rnr.2	-	14	2114	c.1495C>T	c.(1495-1497)CGA>TGA	p.R499*	GALNT14_uc002rnq.2_Nonsense_Mutation_p.R479*|GALNT14_uc002rns.2_Nonsense_Mutation_p.R504*|GALNT14_uc010ymr.1_Nonsense_Mutation_p.R464*	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	499	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					CTTACCTGTCGGTCATCTCCA	0.532000													22	80					0	0	0.014323	0	0
XDH	7498	broad.mit.edu	37	2	31599949	31599949	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:31599949G>A	uc002rnv.1	-	14	1476	c.1397C>T	c.(1396-1398)GCC>GTC	p.A466V		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	466					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGTCTTGAGGGCTGAGATGGT	0.413000													27	93					0	0	0.010818	0	0
RPL23AP32	56969	broad.mit.edu	37	2	54756602	54756602	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:54756602C>T	uc010yot.1	+	1	244	c.120C>T	c.(118-120)ATC>ATT	p.I40I	SPTBN1_uc002rxu.2_Intron|SPTBN1_uc002rxv.1_Intron	NR_002229				SubName: Full=Putative uncharacterized protein DKFZp547I014;												0						AAAAGAAGATCCGCATGTCAC	0.542000													9	44					0	0	0.006214	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975883	76975883	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:76975883A>G	uc002snr.2	-	4	2126	c.1711T>C	c.(1711-1713)TTC>CTC	p.F571L	LRRTM4_uc002snq.2_Missense_Mutation_p.F571L	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	571	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GTGGCGATGAAGCTGTGGTCT	0.617000													28	130					0	0	0.012213	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88882949	88882949	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:88882949G>A	uc002stc.3	-	10	1964	c.1762C>T	c.(1762-1764)CGA>TGA	p.R588*		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	588	Cytoplasmic (Potential).		R -> Q (in WRS; in a Pakistani family; probable complete loss of activity).		activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						GACTCTTACCGTGATATATAT	0.303000													60	276					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	2	89339959	89339959	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:89339959C>T	uc010ytr.1	-	64		c.5900G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GACTCTGTCTCCTACAGATGC	0.478000													15	120					0	0	0.006122	0	0
Unknown	0	broad.mit.edu	37	2	90139155	90139155	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:90139155C>T	uc010fhm.2	+	17		c.2067C>T								Parts of antibodies, mostly variable regions.																		TGCTCTGTTTCCCAGGTAAGG	0.498000													10	132					0	0	0.010729	0	0
PROM2	150696	broad.mit.edu	37	2	95942371	95942371	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:95942371C>T	uc002suh.1	+	5	781	c.648C>T	c.(646-648)TCC>TCT	p.S216S	PROM2_uc002sui.2_Silent_p.S216S|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.S216S|PROM2_uc002sul.2_Intron	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	216	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						AGCAATTCTCCCTGCCCCAGG	0.657000													9	38					0	0	0.004482	0	0
GPAT2	150763	broad.mit.edu	37	2	96689176	96689176	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:96689176G>A	uc002svf.2	-	18	2132	c.1909C>T	c.(1909-1911)CGG>TGG	p.R637W	GPAT2_uc002svd.2_Missense_Mutation_p.R456W|GPAT2_uc002sve.2_Missense_Mutation_p.R439W|GPAT2_uc002svg.2_Missense_Mutation_p.R516W|GPAT2_uc010yuh.1_Missense_Mutation_p.R566W|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	637					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						CAGGCTGGCCGGGAGCCTGGG	0.582000													11	36					0	0	0.020292	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952165	96952165	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:96952165G>A	uc002svu.2	-	29	3973	c.3887C>T	c.(3886-3888)CCC>CTC	p.P1296L	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Missense_Mutation_p.P368L	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1296						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						GGTTGGAGGGGGGTACTTCTC	0.498000													14	67					0	0	0.020292	0	0
VWA3B	200403	broad.mit.edu	37	2	98851193	98851193	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:98851193C>T	uc002syo.2	+	17	2655	c.2391C>T	c.(2389-2391)TCC>TCT	p.S797S	VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Silent_p.S316S|VWA3B_uc002sym.2_Silent_p.S797S|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Silent_p.S454S|VWA3B_uc002syp.1_Silent_p.S189S|VWA3B_uc002syq.1_Silent_p.S73S|VWA3B_uc002syr.1_Silent_p.S114S|VWA3B_uc010fih.1_5'Flank	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	797										ovary(3)|large_intestine(2)|skin(1)	6						ATGGCCTCTCCAATGCCAGCA	0.532000													8	40					0	0	0.003080	0	0
C2orf55	343990	broad.mit.edu	37	2	99448866	99448866	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:99448866C>T	uc002szf.1	-	5	779	c.485G>A	c.(484-486)AGG>AAG	p.R162K		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	162											0						TGGGGGGCTCCTGGGCAGCCC	0.622000													17	56					0	0	0.028581	0	0
MRPS9	64965	broad.mit.edu	37	2	105716142	105716142	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:105716142A>G	uc002tcn.3	+	11	1182	c.1114A>G	c.(1114-1116)ACT>GCT	p.T372A		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	372					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						ACTACTTACTACTGATCCACG	0.468000													5	30					0	0	0.021553	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459497	107459497	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:107459497C>T	uc002tdq.2	-	2	1056	c.937G>A	c.(937-939)GAA>AAA	p.E313K	ST6GAL2_uc002tdr.2_Missense_Mutation_p.E313K|ST6GAL2_uc002tds.3_Missense_Mutation_p.E313K	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	313	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CTACCTATTTCCTCGCCCAAG	0.667000													5	11					0	0	0.021553	0	0
MARCO	8685	broad.mit.edu	37	2	119727733	119727733	+	Silent	SNP	C	T	T	rs75633112		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:119727733C>T	uc002tln.1	+	3	375	c.243C>T	c.(241-243)TTC>TTT	p.F81F	MARCO_uc010yyf.1_Silent_p.F3F	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	81	Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						AGATGTATTTCCTCAATGACA	0.582000													25	38					0	0	0.027356	0	0
SCN7A	6332	broad.mit.edu	37	2	167297944	167297944	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:167297944G>A	uc002udu.1	-	14	2246	c.2119C>T	c.(2119-2121)CCT>TCT	p.P707S	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	707	Helical; Name=S6 of repeat II; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AGGTAAAAAGGAATACACCAG	0.393000													10	12					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179414910	179414910	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:179414910C>T	uc010zfg.1	-	286	84175	c.83951G>A	c.(83950-83952)GGA>GAA	p.G27984E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G21679E|TTN_uc010zfi.1_Missense_Mutation_p.G21612E|TTN_uc010zfj.1_Missense_Mutation_p.G21487E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28911							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGGTCTTCCTTGTACCAA	0.408000													69	95					0	0	0.014410	0	0
TTN	7273	broad.mit.edu	37	2	179569401	179569401	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:179569401G>A	uc010zfg.1	-	102	26290	c.26066C>T	c.(26065-26067)TCG>TTG	p.S8689L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S5350L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9616							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGTACCACGAAAGCTTGAT	0.338000													11	22					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179613791	179613791	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:179613791C>T	uc002unb.2	-	46	13560	c.13336G>A	c.(13336-13338)GGT>AGT	p.G4446S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTCTTCACCAAGGGATTCT	0.353000													6	40					0	0	0.021553	0	0
TTN	7273	broad.mit.edu	37	2	179632521	179632521	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:179632521C>T	uc010zfg.1	-	40	9660	c.9436G>A	c.(9436-9438)GAT>AAT	p.D3146N	TTN_uc010zfh.1_Missense_Mutation_p.D3100N|TTN_uc010zfi.1_Missense_Mutation_p.D3100N|TTN_uc010zfj.1_Missense_Mutation_p.D3100N|TTN_uc002unb.2_Missense_Mutation_p.D3146N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3146							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCGAACATCTCTGCCTTCT	0.418000													25	45					0	0	0.021523	0	0
SLC39A10	57181	broad.mit.edu	37	2	196571437	196571437	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:196571437C>T	uc002utg.3	+	4	1528	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	SLC39A10_uc002uth.3_Silent_p.F438F|SLC39A10_uc010zgp.1_5'UTR	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	438	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GCTTCAAATTCCTTCTTACAT	0.393000													14	27					0	0	0.004990	0	0
DNAH7	56171	broad.mit.edu	37	2	196786915	196786915	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:196786915G>A	uc002utj.3	-	24	3933	c.3832C>T	c.(3832-3834)CAT>TAT	p.H1278Y		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1278	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GTTTCTAAATGATTTTCCTAG	0.289000													8	22					0	0	0.006214	0	0
FBXO36	130888	broad.mit.edu	37	2	230875489	230875490	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:230875489_230875490GG>AA	uc002vqa.2	+	4	479_480	c.456_457GG>AA	c.(454-459)CTGGCG>CTAACG	p.A153T	FBXO36_uc002vqb.2_Missense_Mutation_p.A122T|FBXO36_uc010fxi.1_Intron|FBXO36_uc002vqc.2_RNA	NM_174899	NP_777559	Q8NEA4	FBX36_HUMAN	F-box protein 36	153										ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0179)|Lung NSC(271;0.0804)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;7.56e-14)|all cancers(144;7.74e-11)|Lung(119;0.00488)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGAGGGCCCTGGCGGAGGACAC	0.540000													10	18					0	0	0.004672	0	0
SIRPG	55423	broad.mit.edu	37	20	1616113	1616113	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:1616113C>T	uc002wfm.1	-	4	946	c.881G>A	c.(880-882)AGA>AAA	p.R294K	SIRPG_uc002wfn.1_Intron|SIRPG_uc002wfo.1_Intron|uc002wfp.1_Intron	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	294	Extracellular (Potential).|Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						GGCTGTTTCTCTCTGGCACAC	0.532000													21	122					0	0	0.014323	0	0
RASSF2	9770	broad.mit.edu	37	20	4770301	4770301	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:4770301G>C	uc002wld.2	-	7	634	c.580C>G	c.(580-582)CGC>GGC	p.R194G	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.R194G|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	194	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding	p.R194H(1)		ovary(3)|lung(2)|large_intestine(1)	6						CTGTTGATGCGGACGTTGGTG	0.547000													15	67					0	0	0.007413	0	0
PLCG1	5335	broad.mit.edu	37	20	39801087	39801087	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:39801087C>T	uc002xjp.1	+	26	3053	c.2932C>T	c.(2932-2934)CGG>TGG	p.R978W	PLCG1_uc002xjo.1_Missense_Mutation_p.R978W|PLCG1_uc010zwe.1_Missense_Mutation_p.R604W	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	978	PI-PLC Y-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				TGCTTGCTACCGGGACATGTC	0.517000													7	21					0	0	0.001984	0	0
TOX2	84969	broad.mit.edu	37	20	42694734	42694734	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:42694734C>T	uc002xlf.3	+	6	1306	c.1289C>T	c.(1288-1290)CCT>CTT	p.P430L	TOX2_uc010ggo.2_Missense_Mutation_p.P448L|TOX2_uc002xle.3_Missense_Mutation_p.P406L|TOX2_uc010ggp.2_Missense_Mutation_p.P406L|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Missense_Mutation_p.P326L	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	430	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGCCCCTCACCTCCAGGGCCA	0.587000													3	8					0	0	0.004672	0	0
RIMS4	140730	broad.mit.edu	37	20	43385542	43385542	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:43385542G>A	uc002xms.2	-	5	588	c.588C>T	c.(586-588)CTC>CTT	p.L196L	RIMS4_uc010ggu.2_Silent_p.L197L	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	196	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				CCCTCACCTGGAGGACTTTGC	0.582000													36	148					0	0	0.019004	0	0
NFATC2	4773	broad.mit.edu	37	20	50139727	50139727	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:50139727G>A	uc002xwd.2	-	2	1273	c.1053C>T	c.(1051-1053)TTC>TTT	p.F351F	NFATC2_uc002xwc.2_Silent_p.F351F|NFATC2_uc010zyv.1_Silent_p.F132F|NFATC2_uc010zyw.1_Silent_p.F132F|NFATC2_uc010zyx.1_Silent_p.F331F|NFATC2_uc010zyy.1_Silent_p.F132F|NFATC2_uc010zyz.1_Silent_p.F132F|NFATC2_uc002xwe.2_Silent_p.F331F	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	351					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					AGGGCCCCAGGAACTCCACGG	0.677000													19	108					0	0	0.006122	0	0
ZNF831	128611	broad.mit.edu	37	20	57829131	57829131	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr20:57829131C>T	uc002yan.2	+	5	4367	c.4367C>T	c.(4366-4368)TCA>TTA	p.S1456L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1456						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCCCAGGATTCAGTCTCAACA	0.522000													13	40					0	0	0.013537	0	0
C21orf81	391267	broad.mit.edu	37	21	15352143	15352143	+	RNA	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:15352143C>T	uc002yji.2	-	1		c.623G>A			C21orf81_uc002yjj.3_RNA	NR_027270				Homo sapiens C21orf81 protein (C21orf81) mRNA, complete cds.												0						GTACCGGATTCGGTACCCGGA	0.622000													4	16					0	0	0.009096	0	0
SON	6651	broad.mit.edu	37	21	34926484	34926484	+	Silent	SNP	T	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:34926484T>G	uc002yse.1	+	3	4996	c.4947T>G	c.(4945-4947)GGT>GGG	p.G1649G	SON_uc002ysb.1_Silent_p.G1649G|SON_uc002ysc.2_Silent_p.G1649G|SON_uc002ysd.2_Silent_p.G640G|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Silent_p.G640G	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1649					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GTCCTAGTGGTGGTAGTGAAG	0.353000													11	48					0	0	0.010729	0	0
HLCS	3141	broad.mit.edu	37	21	38309625	38309625	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:38309625G>A	uc010gnb.2	-	4	1321	c.120C>T	c.(118-120)ATC>ATT	p.I40I	HLCS_uc002yvs.2_Silent_p.I40I|HLCS_uc010gnc.1_Silent_p.I187I	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	40					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	TCGGCTCTAGGATCTGGGCTT	0.498000													20	45					0	0	0.010504	0	0
PWP2	5822	broad.mit.edu	37	21	45548478	45548478	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:45548478C>T	uc002zeb.2	+	20	2646	c.2556C>T	c.(2554-2556)ATC>ATT	p.I852I		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	852						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		AGAAGAGCATCCAGCGGCACC	0.642000													10	22					0	0	0.020292	0	0
KRTAP10-4	386672	broad.mit.edu	37	21	45994720	45994720	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:45994720C>T	uc002zfk.1	+	1	1115	c.1085C>T	c.(1084-1086)TCC>TTC	p.S362F	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	362	36 X 5 AA repeats of C-C-X(3).					keratin filament					0						TCCTCCGTGTCCCTCCTCTGC	0.677000													26	73					0	0	0.006320	0	0
LOC96610	96610	broad.mit.edu	37	22	23081587	23081587	+	Splice_Site	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:23081587C>T	uc011aim.1	+	197		c.10335_splice	c.e197-2							Parts of antibodies, mostly variable regions.												0						GGCTCCAAGTCAGGAACACAG	0.527000													4	21					0	0	0.014758	0	0
MYO18B	84700	broad.mit.edu	37	22	26219542	26219542	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:26219542G>A	uc003abz.1	+	13	2842	c.2592G>A	c.(2590-2592)GAG>GAA	p.E864E	MYO18B_uc003aca.1_Silent_p.E745E|MYO18B_uc010guy.1_Silent_p.E745E|MYO18B_uc010guz.1_Silent_p.E745E|MYO18B_uc011aka.1_Silent_p.E18E|MYO18B_uc011akb.1_Silent_p.E377E	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	864	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GCGAGTATGAGGAGCTGAACA	0.572000													24	100					0	0	0.021523	0	0
PATZ1	23598	broad.mit.edu	37	22	31722980	31722980	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:31722980G>A	uc003akq.2	-	5	2622	c.1961C>T	c.(1960-1962)TCT>TTT	p.S654F	PATZ1_uc003akp.2_3'UTR|PATZ1_uc003akr.2_Missense_Mutation_p.S608F	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	654					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CTCGAGGAGAGACATGTTCTG	0.567000													24	51					0	0	0.024334	0	0
SMCR7L	54471	broad.mit.edu	37	22	39909778	39909779	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:39909778_39909779CC>AT	uc003axx.2	+	6	1340_1341	c.842_843CC>AT	c.(841-843)TCC>TAT	p.S281Y	SMCR7L_uc003axw.2_Missense_Mutation_p.S281Y|SMCR7L_uc010gxz.1_Missense_Mutation_p.S103Y|SMCR7L_uc003axy.2_Missense_Mutation_p.S103Y	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	281						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					GCCATAGGGTCCCTCTTGGACT	0.554000											OREG0026577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	45					0	0	0.004672	0	0
RIBC2	26150	broad.mit.edu	37	22	45818182	45818182	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:45818182C>T	uc011aqs.1	+	5	763	c.554C>T	c.(553-555)ACA>ATA	p.T185I		NM_015653	NP_056468	Q9H4K1	RIBC2_HUMAN	RIB43A domain with coiled-coils 2	117											0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GCCCTCTACACAGAGACAAGG	0.547000													60	140					0	0	0.014410	0	0
PKDREJ	10343	broad.mit.edu	37	22	46655683	46655683	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:46655683G>A	uc003bhh.2	-	1	3537	c.3537C>T	c.(3535-3537)AGC>AGT	p.S1179S		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1179	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTTGGTGAAGGCTCTTGATGA	0.473000													46	100					0	0	0.014410	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656192	46656192	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:46656192T>G	uc003bhh.2	-	1	3028	c.3028A>C	c.(3028-3030)ACA>CCA	p.T1010P		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1010	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ACCAACACTGTGAACAGCACC	0.537000													20	96					0	0	0.010504	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660915	50660915	+	Missense_Mutation	SNP	G	A	A	rs141188316		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr22:50660915G>A	uc003bkb.1	-	14	2889	c.2377C>T	c.(2377-2379)CGT>TGT	p.R793C	TUBGCP6_uc003bka.1_5'Flank|TUBGCP6_uc010har.1_Missense_Mutation_p.R785C|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	793					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AAGAGAAAACGAAGCCGTGCA	0.562000													22	33					0	0	0.012319	0	0
SRGAP3	9901	broad.mit.edu	37	3	9027346	9027346	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:9027346G>A	uc003brf.1	-	22	3833	c.3157C>T	c.(3157-3159)CGC>TGC	p.R1053C	SRGAP3_uc003brg.1_Missense_Mutation_p.R1029C	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	1053					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGGGGCGGGCGGAGCTGGGCG	0.746000			T	RAF1	pilocytic astrocytoma								4	23					0	0	0.003080	0	0
ARPP21	10777	broad.mit.edu	37	3	35835244	35835244	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:35835244C>G	uc003cgb.2	+	20	2497	c.2233C>G	c.(2233-2235)CCA>GCA	p.P745A	ARPP21_uc003cga.2_Missense_Mutation_p.P726A|ARPP21_uc011axy.1_Missense_Mutation_p.P746A|ARPP21_uc003cgf.2_Missense_Mutation_p.P581A|ARPP21_uc003cgg.2_Missense_Mutation_p.P268A	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	745	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						ATACCAACAGCCAATCATGCT	0.507000													11	29					0	0	0.008291	0	0
SCN10A	6336	broad.mit.edu	37	3	38753670	38753670	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:38753670G>A	uc003ciq.2	-	22	4071	c.4071C>T	c.(4069-4071)TAC>TAT	p.Y1357Y		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1357	III.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GAAGTGCAAGGTAACCCATTG	0.433000													19	54					0	0	0.012319	0	0
SCN11A	11280	broad.mit.edu	37	3	38926851	38926851	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:38926851C>T	uc011ays.1	-	17	3191	c.2992G>A	c.(2992-2994)GAT>AAT	p.D998N	SCN11A_uc010hhn.1_Missense_Mutation_p.D76N	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	998					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCCTGAAGATCAATGGTGCTA	0.433000													12	25					0	0	0.020292	0	0
CCDC71	64925	broad.mit.edu	37	3	49200967	49200967	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:49200967G>A	uc003cwg.3	-	2	813	c.675C>T	c.(673-675)CCC>CCT	p.P225P		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	225										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGGGAGCTTTGGGCCGAGGGT	0.597000													21	70					0	0	0.016522	0	0
RNF123	63891	broad.mit.edu	37	3	49742550	49742550	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:49742550C>T	uc003cxh.2	+	23	2179	c.2093C>T	c.(2092-2094)CCT>CTT	p.P698L	RNF123_uc010hky.1_Missense_Mutation_p.P360L|RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	698						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CCACGGCGGCCTCTGAGCACC	0.667000													4	7					0	0	0.014758	0	0
IFRD2	7866	broad.mit.edu	37	3	50326035	50326035	+	Silent	SNP	C	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:50326035C>A	uc011bdp.1	-	10	1452	c.1323G>T	c.(1321-1323)TCG>TCT	p.S441S	IFRD2_uc003czb.2_Silent_p.S543S	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	441							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGTGCATGCCCGAACCCAGCA	0.612000													3	19					0.000602214	0.000776075	0.014758	1	0
ERC2	26059	broad.mit.edu	37	3	55768834	55768834	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:55768834C>T	uc003dhr.1	-	15	2933	c.2677G>A	c.(2677-2679)GAA>AAA	p.E893K	ERC2_uc003dhq.1_RNA|ERC2_uc003dht.1_Missense_Mutation_p.E372K	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	893	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CGGTCTTTTTCCCGCTTGAGG	0.483000													9	19					0	0	0.008291	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053841	67053841	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:67053841G>A	uc003dmy.2	+	3	503	c.450G>A	c.(448-450)CAG>CAA	p.Q150Q	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	150										ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TGGACCCACAGAATTCTATTG	0.413000													19	36					0	0	0.007413	0	0
ROBO2	6092	broad.mit.edu	37	3	77684173	77684173	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:77684173C>T	uc003dpy.3	+	24	4556	c.3913C>T	c.(3913-3915)CGA>TGA	p.R1305*	ROBO2_uc003dpz.2_Nonsense_Mutation_p.R1370*|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Nonsense_Mutation_p.R1309*	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1305	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATTGCCTCATCGAAGGGAAGG	0.483000													8	27					0	0	0.004482	0	0
OR5K3	403277	broad.mit.edu	37	3	98109620	98109620	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:98109620C>T	uc011bgw.1	+	1	111	c.111C>T	c.(109-111)ATC>ATT	p.I37I		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTATCTGATCACCATGGTGG	0.403000													21	86					0	0	0.012319	0	0
LNP1	348801	broad.mit.edu	37	3	100174744	100174744	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:100174744C>T	uc003dtx.3	+	4	1791	c.511C>T	c.(511-513)CCC>TCC	p.P171S	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	171											0						ACACATGGCTCCCCTGTTTGA	0.423000													8	59					0	0	0.004482	0	0
DPPA2	151871	broad.mit.edu	37	3	109031524	109031524	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:109031524C>T	uc003dxo.2	-	3	296	c.49G>A	c.(49-51)GAA>AAA	p.E17K		NM_138815	NP_620170	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	17						nucleus	nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)	3						TCATCTACTTCCCCCTCCAAG	0.398000													14	50					0	0	0.004990	0	0
SLC9A10	285335	broad.mit.edu	37	3	111927207	111927207	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:111927207G>A	uc003dyu.2	-	16	2026	c.1804C>T	c.(1804-1806)CGT>TGT	p.R602C	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.R554C	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	602	Ion transport-like.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TGGCATATACGAAAAAAGAAG	0.269000													10	63					0	0	0.008291	0	0
ILDR1	286676	broad.mit.edu	37	3	121712426	121712426	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:121712426C>T	uc003ees.2	-	7	1276	c.1170G>A	c.(1168-1170)TTG>TTA	p.L390L	ILDR1_uc003eeq.2_Silent_p.L358L|ILDR1_uc003eer.2_Silent_p.L346L|ILDR1_uc010hrg.2_Silent_p.L301L	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	390	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		CCCTTCTTTCCAATGCCCAAG	0.587000													11	42					0	0	0.010729	0	0
ADCY5	111	broad.mit.edu	37	3	123009975	123009975	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:123009975G>A	uc003egh.1	-	18	3312	c.3312C>T	c.(3310-3312)ATC>ATT	p.I1104I	ADCY5_uc003egg.1_Silent_p.I762I	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	1104	Cytoplasmic (Potential).|Guanylate cyclase 2.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		CAAAGTCAGCGATGATCTCAT	0.592000													5	18					0	0	0.014758	0	0
KALRN	8997	broad.mit.edu	37	3	124209608	124209608	+	Silent	SNP	G	A	A	rs139928910		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:124209608G>A	uc003ehg.2	+	30	4585	c.4458G>A	c.(4456-4458)CCG>CCA	p.P1486P	KALRN_uc010hrv.1_Silent_p.P1477P|KALRN_uc003ehf.1_Silent_p.P1486P|KALRN_uc011bjy.1_Silent_p.P1477P	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1486	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TGTGGGACCCGAAGTCGCTGA	0.507000													9	51					0	0	0.004482	0	0
OSBPL11	114885	broad.mit.edu	37	3	125249392	125249392	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:125249392C>T	uc003eic.2	-	13	2948	c.2211G>A	c.(2209-2211)TGG>TGA	p.W737*		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	737					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						GAATTATTTTCCAAAGTGGTT	0.358000													11	33					0	0	0.016723	0	0
COL29A1	256076	broad.mit.edu	37	3	130188179	130188179	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:130188179C>T	uc010htj.1	+	38	7825	c.7331C>T	c.(7330-7332)TCC>TTC	p.S2444F	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.S483F	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2444	VWFA 10.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						TTTGTGTTTTCCTTTGGCCCT	0.443000													8	22					0	0	0.004482	0	0
A4GNT	51146	broad.mit.edu	37	3	137843166	137843166	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:137843166C>T	uc003ers.2	-	3	1165	c.963G>A	c.(961-963)AGG>AGA	p.R321R		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	321	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						TAATCAGGTCCCTGTAAGTCC	0.517000													100	326					0	0	0.014410	0	0
CCNL1	57018	broad.mit.edu	37	3	156867343	156867343	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:156867343G>A	uc003fbf.2	-	9	1663	c.1064C>T	c.(1063-1065)TCC>TTC	p.S355F	CCNL1_uc003fbd.1_Missense_Mutation_p.S355F|CCNL1_uc003fbe.2_Missense_Mutation_p.S149F|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA|CCNL1_uc003fbi.1_Missense_Mutation_p.S200F	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	355					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			CACATTAATGGAGATTGGTGA	0.383000													14	68					0	0	0.024245	0	0
SERPINI2	5276	broad.mit.edu	37	3	167183106	167183106	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:167183106G>A	uc003fer.1	-	4	812	c.754C>T	c.(754-756)CTT>TTT	p.L252F	SERPINI2_uc003fes.1_Missense_Mutation_p.L262F|SERPINI2_uc003fet.1_Missense_Mutation_p.L252F	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	252					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						TCTGCAGGAAGTATGATAATT	0.328000													10	98					0	0	0.024245	0	0
MECOM	2122	broad.mit.edu	37	3	168834004	168834004	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:168834004C>T	uc003ffi.3	-	7	1361	c.1092G>A	c.(1090-1092)GGG>GGA	p.G364G	MECOM_uc010hwk.1_Silent_p.G387G|MECOM_uc003ffj.3_Silent_p.G429G|MECOM_uc011bpi.1_Silent_p.G365G|MECOM_uc003ffn.3_Silent_p.G364G|MECOM_uc003ffk.2_Silent_p.G364G|MECOM_uc003ffl.2_Silent_p.G524G|MECOM_uc011bpj.1_Silent_p.G552G|MECOM_uc011bpk.1_Silent_p.G354G|MECOM_uc010hwn.2_Silent_p.G552G	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	364					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						GCTTATTGTCCCCTACAGATG	0.473000													7	37					0	0	0.001984	0	0
SOX2	6657	broad.mit.edu	37	3	181430308	181430308	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:181430308G>A	uc003fkx.2	+	1	587	c.160G>A	c.(160-162)GGG>AGG	p.G54R	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	54	HMG box.				cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			GTGGTCCCGCGGGCAGCGGCG	0.662000			A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						7	24					0	0	0.004482	0	0
HTR3E	285242	broad.mit.edu	37	3	183823756	183823756	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:183823756C>T	uc010hxq.2	+	7	1390	c.924C>T	c.(922-924)ATC>ATT	p.I308I	HTR3E_uc003fml.3_Silent_p.I293I|HTR3E_uc003fmm.2_Silent_p.I323I|HTR3E_uc010hxr.2_Silent_p.I334I|HTR3E_uc003fmn.2_Silent_p.I308I	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	308	Helical; Name=3; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CCCCCCTCATCGGTATGGCTC	0.547000													18	85					0	0	0.008871	0	0
EVC2	132884	broad.mit.edu	37	4	5667321	5667321	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:5667321G>A	uc003gij.2	-	8	980	c.926C>T	c.(925-927)TCC>TTC	p.S309F	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.S229F	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	309	Helical; (Potential).					integral to membrane				large_intestine(3)|ovary(2)	5						CAGCACAAGGGAGAGGAGGAA	0.577000													8	33					0	0	0.004482	0	0
DRD5	1816	broad.mit.edu	37	4	9784903	9784903	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:9784903C>T	uc003gmb.3	+	1	1646	c.1250C>T	c.(1249-1251)GCC>GTC	p.A417V		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	417	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATGCCCAACGCCGTTACCCCC	0.552000													5	38					0	0	0.021553	0	0
SLIT2	9353	broad.mit.edu	37	4	20512738	20512738	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:20512738G>A	uc003gpr.1	+	11	1240	c.1036G>A	c.(1036-1038)GGA>AGA	p.G346R	SLIT2_uc003gps.1_Missense_Mutation_p.G346R	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	346	LRR 8.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGCTTTCCAAGGACTACGCTC	0.383000													13	29					0	0	0.028581	0	0
CCKAR	886	broad.mit.edu	37	4	26483701	26483701	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:26483701G>A	uc003gse.1	-	5	999	c.846C>T	c.(844-846)CTC>CTT	p.L282L		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	282	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	ACAGCTGCCGGAGCTCCAGCT	0.607000													17	54					0	0	0.028581	0	0
ATP10D	57205	broad.mit.edu	37	4	47537581	47537581	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:47537581G>A	uc003gxk.1	+	6	996	c.832G>A	c.(832-834)GGA>AGA	p.G278R	ATP10D_uc003gxl.1_5'Flank|ATP10D_uc003gxj.3_Missense_Mutation_p.G278R	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	278	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GTTGCTTAGAGGATGCACCAT	0.373000													10	50					0	0	0.010729	0	0
CWH43	80157	broad.mit.edu	37	4	48990598	48990598	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:48990598C>T	uc003gyv.2	+	2	330	c.148C>T	c.(148-150)CTT>TTT	p.L50F	CWH43_uc011bzl.1_Missense_Mutation_p.L23F	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	50	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TATAGCATTTCTTTCTCCAAT	0.378000													8	38					0	0	0.003080	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535624	69535624	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:69535624C>T	uc011cal.1	-	1	751	c.713G>A	c.(712-714)AGT>AAT	p.S238N		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	238					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TAGAACTTCACTATAAAACTG	0.308000													25	110					0	0	0.009535	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817356	69817356	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:69817356G>A	uc003hef.2	-	1	154	c.123C>T	c.(121-123)GTC>GTT	p.V41V	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	41	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CTTCTAGAATGACCTTGACAT	0.463000													13	45					0	0	0.016723	0	0
COX18	285521	broad.mit.edu	37	4	73930991	73930991	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:73930991T>C	uc003hgm.1	-	3	680	c.574A>G	c.(574-576)AGC>GGC	p.S192G	COX18_uc003hgn.1_Missense_Mutation_p.S41G|COX18_uc011cbc.1_Missense_Mutation_p.S192G|COX18_uc010iih.1_Missense_Mutation_p.S192G	NM_173827	NP_776188	Q8N8Q8	COX18_HUMAN	mitochondrial COX18 precursor	192					protein insertion into mitochondrial membrane|respiratory chain complex IV assembly	integral to mitochondrial inner membrane	protein transporter activity				0	Breast(15;0.00096)		Epithelial(6;1.26e-06)|OV - Ovarian serous cystadenocarcinoma(6;9.45e-06)|all cancers(17;2.05e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GCCCCCGTGCTTAAATTCCGG	0.378000													11	35					0	0	0.010729	0	0
CDS1	1040	broad.mit.edu	37	4	85538786	85538786	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:85538786G>A	uc011ccv.1	+	4	910	c.412G>A	c.(412-414)GAT>AAT	p.D138N		NM_001263	NP_001254	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase 1	138					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			large_intestine(2)|ovary(1)|breast(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TCATTCTTATGATCTACCATG	0.328000													11	36					0	0	0.020292	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169876	90169876	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:90169876G>A	uc003hsm.1	-	2	1905	c.1386C>T	c.(1384-1386)TCC>TCT	p.S462S		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	462										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TAGCTTTCAGGGAGCTAGAAT	0.458000													19	63					0	0	0.006122	0	0
ADH1B	125	broad.mit.edu	37	4	100237269	100237269	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:100237269C>T	uc003hus.3	-	5	437	c.353G>A	c.(352-354)GGC>GAC	p.G118D	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.G78D|ADH1B_uc011ceh.1_Intron|ADH1B_uc011cei.1_Missense_Mutation_p.G78D	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	118					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	CCGAGGATTGCCTAGACTGGG	0.537000													8	23					0	0	0.003080	0	0
UGT8	7368	broad.mit.edu	37	4	115544202	115544202	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:115544202C>T	uc003ibs.2	+	2	688	c.166C>T	c.(166-168)CTC>TTC	p.L56F	UGT8_uc003ibt.2_Missense_Mutation_p.L56F|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	56					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		AGTGTTCCTCCTCTCTGAAGG	0.488000													11	46					0	0	0.010729	0	0
NDST3	9348	broad.mit.edu	37	4	118975786	118975786	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:118975786C>T	uc003ibx.2	+	2	1124	c.721C>T	c.(721-723)CCA>TCA	p.P241S	NDST3_uc011cgf.1_Missense_Mutation_p.P241S|NDST3_uc003ibw.2_Missense_Mutation_p.P241S	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	241	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						AGTAAAGACCCCAGAAAACCT	0.388000													4	80					0	0	0.009096	0	0
FABP2	2169	broad.mit.edu	37	4	120241838	120241838	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:120241838C>T	uc003icw.2	-	2	286	c.227G>A	c.(226-228)GGA>GAA	p.G76E		NM_000134	NP_000125	P12104	FABPI_HUMAN	intestinal fatty acid binding protein 2	76							fatty acid binding			ovary(1)	1						GAGTTCAGTTCCGTCTGCTAG	0.318000													8	41					0	0	0.004482	0	0
INPP4B	8821	broad.mit.edu	37	4	142949951	142949952	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:142949951_142949952CC>TT	uc003iix.3	-	27	3353_3354	c.2758_2759GG>AA	c.(2758-2760)GGA>AAA	p.G920K	INPP4B_uc003iiw.3_Missense_Mutation_p.G920K|INPP4B_uc011chm.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	920					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					GTCAGCTTTTCCATAAGTCCCC	0.366000													6	40					0	0	0.004672	0	0
FGB	2244	broad.mit.edu	37	4	155490686	155490686	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:155490686G>A	uc003ioa.3	+	7	1018	c.979G>A	c.(979-981)GAT>AAT	p.D327N	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.D265N|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.D108N	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	327	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GCTTGGAAATGATAAAATTAG	0.358000													15	56					0	0	0.024245	0	0
GRIA2	2891	broad.mit.edu	37	4	158224858	158224858	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:158224858G>A	uc003ipm.3	+	3	843	c.384G>A	c.(382-384)ATG>ATA	p.M128I	GRIA2_uc011cit.1_Missense_Mutation_p.M81I|GRIA2_uc003ipl.3_Missense_Mutation_p.M128I|GRIA2_uc003ipk.3_Missense_Mutation_p.M81I|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	128	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TCATTCAGATGAGACCCGACC	0.448000													38	110					0	0	0.008740	0	0
TLL1	7092	broad.mit.edu	37	4	166915607	166915607	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:166915607C>T	uc003irh.1	+	4	1083	c.436C>T	c.(436-438)CCC>TCC	p.P146S	TLL1_uc011cjn.1_Missense_Mutation_p.P146S|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	146					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AAATCGAGTTCCCAGAGCCGC	0.423000													7	46					0	0	0.001984	0	0
ODZ3	55714	broad.mit.edu	37	4	183694733	183694733	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:183694733C>T	uc003ivd.1	+	22	5038	c.5001C>T	c.(4999-5001)AGC>AGT	p.S1667S		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1667	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGTCATCTAGCCGAGAAGAAG	0.443000													20	97					0	0	0.012319	0	0
WWC2	80014	broad.mit.edu	37	4	184174999	184174999	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:184174999T>A	uc010irx.2	+	9	1225	c.1043T>A	c.(1042-1044)ATT>AAT	p.I348N	WWC2_uc003ivk.3_Missense_Mutation_p.I143N|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.I30N	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	348	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		CTGATGCTGATTAATGAAAAA	0.418000													5	14					0	0	0.014758	0	0
KLKB1	3818	broad.mit.edu	37	4	187158021	187158021	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr4:187158021A>C	uc003iyy.2	+	5	486	c.415A>C	c.(415-417)AAA>CAA	p.K139Q	KLKB1_uc011clc.1_5'UTR|KLKB1_uc011cld.1_Missense_Mutation_p.K101Q	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	139	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		AGAATGCCAAAAAAGGTGCAC	0.398000													16	49					0	0	0.004990	0	0
SLC6A18	348932	broad.mit.edu	37	5	1235773	1235773	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:1235773G>A	uc003jby.1	+	4	740	c.617G>A	c.(616-618)GGG>GAG	p.G206E		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	206	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGACTACAGGGAAGGTGAGA	0.562000													13	73					0	0	0.016723	0	0
DNAH5	1767	broad.mit.edu	37	5	13751285	13751285	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:13751285G>A	uc003jfd.2	-	65	11155	c.11113C>T	c.(11113-11115)CCT>TCT	p.P3705S	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3705	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTATCTCAGGGGTGTAGGCT	0.438000									Kartagener_syndrome				14	51					0	0	0.016723	0	0
DNAH5	1767	broad.mit.edu	37	5	13841988	13841988	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:13841988G>A	uc003jfd.2	-	33	5339	c.5297C>T	c.(5296-5298)TCC>TTC	p.S1766F		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1766	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTCTTGAGAGGAAATTGACAG	0.333000									Kartagener_syndrome				7	45					0	0	0.001984	0	0
MARCH11	441061	broad.mit.edu	37	5	16067884	16067884	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:16067884C>T	uc003jfo.2	-	4	1118	c.905G>A	c.(904-906)GGA>GAA	p.G302E	MARCH11_uc010itw.1_Missense_Mutation_p.G58E	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	302						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						AACTGCAGCTCCTTCATGAAC	0.403000													6	25					0	0	0.021553	0	0
C5orf42	65250	broad.mit.edu	37	5	37198860	37198860	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:37198860G>A	uc011cpa.1	-	20	3847	c.3616C>T	c.(3616-3618)CCT>TCT	p.P1206S	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.P281S|C5orf42_uc011cpb.1_Missense_Mutation_p.P87S	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1206										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGTGCTACAGGAAAAGAACAC	0.403000													7	49					0	0	0.004482	0	0
DAB2	1601	broad.mit.edu	37	5	39394359	39394359	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:39394359C>T	uc003jlx.2	-	2	595	c.64G>A	c.(64-66)GCA>ACA	p.A22T	DAB2_uc003jlw.2_Missense_Mutation_p.A22T	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	22					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TTTGAGGGTGCTTTTGGTGCG	0.483000													10	48					0	0	0.008291	0	0
C7	730	broad.mit.edu	37	5	40945458	40945458	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:40945458C>T	uc003jmh.2	+	7	840	c.726C>T	c.(724-726)ATC>ATT	p.I242I	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	242	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CCAATGAAATCCATAAAGGAA	0.318000													3	17					0	0	0.009096	0	0
C6	729	broad.mit.edu	37	5	41181562	41181562	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:41181562C>T	uc003jmk.2	-	7	1036	c.826G>A	c.(826-828)GGG>AGG	p.G276R	C6_uc003jml.1_Missense_Mutation_p.G276R	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	276	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AAAGAGCTCCCCCCCTGACTT	0.378000													9	47					0	0	0.010729	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382492	41382492	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:41382492T>C	uc003jmm.1	-	2	350	c.248A>G	c.(247-249)AAT>AGT	p.N83S		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	83	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GCCAGTAAAATTCATTGTCTG	0.453000													8	48					0	0	0.006214	0	0
IL31RA	133396	broad.mit.edu	37	5	55168166	55168166	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:55168166C>T	uc003jql.2	+	4	406	c.341C>T	c.(340-342)TCT>TTT	p.S114F	IL31RA_uc003jqk.2_Missense_Mutation_p.S114F|IL31RA_uc011cqj.1_5'UTR|IL31RA_uc003jqm.2_Missense_Mutation_p.S82F|IL31RA_uc003jqn.2_Missense_Mutation_p.S114F|IL31RA_uc010iwa.1_Missense_Mutation_p.S82F|IL31RA_uc003jqo.2_5'UTR	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	82	Extracellular (Potential).|Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				GCTTCGTGCTCTTTTTTCCTT	0.348000													13	34					0	0	0.016723	0	0
SV2C	22987	broad.mit.edu	37	5	75591627	75591627	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:75591627C>T	uc003kei.1	+	9	1496	c.1362C>T	c.(1360-1362)TTC>TTT	p.F454F		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	454	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCGTTTGGTTCCCTGATGTCA	0.393000													17	103					0	0	0.008871	0	0
LOC441089	441089	broad.mit.edu	37	5	79647333	79647333	+	RNA	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:79647333G>A	uc010jaj.1	-	1		c.453C>T				NR_003665				Homo sapiens CRSP8 pseudogene (LOC441089), non-coding RNA.												0						CTGAGCCTTTGGTCTACTTTT	0.458000													10	32					0	0	0.008291	0	0
VCAN	1462	broad.mit.edu	37	5	82817888	82817888	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:82817888A>G	uc003kii.3	+	7	4119	c.3763A>G	c.(3763-3765)ACA>GCA	p.T1255A	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.T1255A|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1255	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGGAGAATCAACATCTCATGT	0.443000													12	64					0	0	0.013537	0	0
ZNF608	57507	broad.mit.edu	37	5	123984196	123984196	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:123984196G>A	uc003ktq.1	-	4	2004	c.1881C>T	c.(1879-1881)TCC>TCT	p.S627S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Silent_p.S627S|ZNF608_uc003ktt.1_Silent_p.S627S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	627						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CAGCACCAGGGGATGCCGGTG	0.512000													12	28					0	0	0.010729	0	0
CTNNA1	1495	broad.mit.edu	37	5	138160293	138160293	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:138160293C>T	uc003ldh.2	+	6	758	c.663C>T	c.(661-663)CTC>CTT	p.L221L	CTNNA1_uc011cyx.1_Silent_p.L118L|CTNNA1_uc011cyy.1_Silent_p.L98L|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Silent_p.L221L	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	221	Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTCCGATCCTCTATACTGCAT	0.493000													8	39					0	0	0.004482	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166324	140166324	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140166324C>T	uc003lhb.2	+	1	449	c.449C>T	c.(448-450)TCG>TTG	p.S150L	PCDHA1_uc003lha.2_Missense_Mutation_p.S150L|PCDHA1_uc003lgz.2_Missense_Mutation_p.S150L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	150	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTGAATTCGCGTTTTCCG	0.443000													11	78					0	0	0.010729	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188633	140188633	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140188633C>T	uc003lhi.2	+	1	1962	c.1861C>T	c.(1861-1863)CCG>TCG	p.P621S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.P621S|PCDHA4_uc011daa.1_Missense_Mutation_p.P621S	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGCGCATCCCGTTCCGCGT	0.672000													13	50					0	0	0.016723	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202108	140202108	+	Silent	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140202108T>C	uc003lhl.2	+	1	748	c.748T>C	c.(748-750)TTG>CTG	p.L250L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Silent_p.L250L|PCDHA5_uc003lhj.1_Silent_p.L250L	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	250	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATGTCAGATTGTTGGAAAA	0.363000													10	46					0	0	0.008291	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207899	140207899	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140207899C>T	uc003lho.2	+	1	250	c.223C>T	c.(223-225)CTG>TTG	p.L75L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.L75L|PCDHA6_uc011dab.1_Silent_p.L75L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	75	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGGACCTTCTGGAGGTAAA	0.637000													37	128					0	0	0.027894	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221732	140221732	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140221732G>A	uc003lhs.2	+	1	826	c.826G>A	c.(826-828)GCA>ACA	p.A276T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.A276T	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAATGGGGCAATTTCATA	0.388000													8	38					0	0	0.003080	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515444	140515444	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140515444C>T	uc003liq.2	+	1	645	c.428C>T	c.(427-429)CCA>CTA	p.P143L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	143	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTAAAAATCCCAGAGAGCACC	0.443000													17	68					0	0	0.004990	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140763909	140763909	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:140763909T>G	uc003lka.1	+	1	1443	c.1443T>G	c.(1441-1443)AGT>AGG	p.S481R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.S481R	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	481	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACGACAGTGAGGATAATG	0.537000													8	24					0	0	0.003080	0	0
KIF4B	285643	broad.mit.edu	37	5	154394617	154394617	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:154394617G>A	uc010jih.1	+	1	1358	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	400	Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGAGGAGAATGAAAAATTAAG	0.458000													20	97					0	0	0.018920	0	0
KIF4B	285643	broad.mit.edu	37	5	154396033	154396033	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:154396033G>A	uc010jih.1	+	1	2774	c.2614G>A	c.(2614-2616)GGA>AGA	p.G872R		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	872	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ATATTTGATTGGAGAGCTGGT	0.468000													6	28					0	0	0.001984	0	0
ADAM19	8728	broad.mit.edu	37	5	156940501	156940501	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:156940501G>A	uc003lwz.2	-	8	743	c.679C>T	c.(679-681)CGA>TGA	p.R227*	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Nonsense_Mutation_p.R158*	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	227	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGTCTCGTCGATTCTTCTGA	0.488000													8	63					0	0	0.004482	0	0
GABRA6	2559	broad.mit.edu	37	5	161119029	161119029	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:161119029G>A	uc003lyu.2	+	8	1247	c.909G>A	c.(907-909)ATG>ATA	p.M303I	GABRA6_uc003lyv.2_Missense_Mutation_p.M74I	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	303	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCACTGCCATGGATTGGTTCA	0.428000										TCGA Ovarian(5;0.080)			14	46					0	0	0.016723	0	0
RARS	5917	broad.mit.edu	37	5	167919739	167919739	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:167919739C>T	uc003lzx.2	+	3	297	c.256C>T	c.(256-258)CAT>TAT	p.H86Y	RARS_uc011deo.1_5'UTR	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	86					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		GGTCTTTGGTCATGCAATTAA	0.408000													17	69					0	0	0.004990	0	0
LCP2	3937	broad.mit.edu	37	5	169677790	169677790	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr5:169677790G>A	uc003man.1	-	20	1630	c.1423C>T	c.(1423-1425)CGT>TGT	p.R475C	C5orf58_uc003mal.2_Intron|LCP2_uc011des.1_Missense_Mutation_p.R270C|LCP2_uc011det.1_Missense_Mutation_p.R304C	NM_005565	NP_005556	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2	475	SH2.				immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		TTCTGATAACGGATCTGGATG	0.383000													16	64					0	0	0.006122	0	0
GSTM2P1	442245	broad.mit.edu	37	6	111368178	111368179	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr6:111368178_111368179CC>TT	uc003puq.2	-	1	579_580	c.444_445GG>AA	c.(442-447)AAGGAC>AAAAAC	p.D149N		NR_002932				Homo sapiens chromosome 1 truncated glutathione S-transferase M1 mRNA, complete cds.												0						GAGATGAAGTCCTTCAGGTTTG	0.500000													10	24					0	0	0.004672	0	0
RSPO3	84870	broad.mit.edu	37	6	127476502	127476502	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr6:127476502G>A	uc003qar.2	+	4	843	c.553G>A	c.(553-555)GCA>ACA	p.A185T	RSPO3_uc003qas.1_Missense_Mutation_p.A185T	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	185	TSP type-1.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		GCATCCTTCAGCAAAGGGTAA	0.438000													12	26					0	0	0.016723	0	0
THEMIS	387357	broad.mit.edu	37	6	128222009	128222009	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr6:128222009G>A	uc003qbi.2	-	2	388	c.69C>T	c.(67-69)ATC>ATT	p.I23I	THEMIS_uc011ebt.1_Silent_p.I23I|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	23	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TGCCTGCCTGGATTTCTAGAA	0.448000													17	64					0	0	0.008871	0	0
PDE10A	10846	broad.mit.edu	37	6	165863797	165863797	+	Silent	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr6:165863797T>C	uc003qun.2	-	5	490	c.249A>G	c.(247-249)GAA>GAG	p.E83E	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Silent_p.E13E|PDE10A_uc003quo.2_Silent_p.E93E	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	83					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCAACCGTTGTTCTATATAGC	0.328000													10	33					0	0	0.013537	0	0
MICALL2	79778	broad.mit.edu	37	7	1474239	1474239	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:1474239G>A	uc003skj.3	-	17	2855	c.2708C>T	c.(2707-2709)TCC>TTC	p.S903F	MICALL2_uc003skh.3_Silent_p.L110L|MICALL2_uc003ski.3_Silent_p.L388L	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	903						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CTACTACTGGGAGGGGCTGCT	0.627000													14	61					0	0	0.016723	0	0
HDAC9	9734	broad.mit.edu	37	7	18688106	18688106	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:18688106C>T	uc003suh.2	+	10	1299	c.1258C>T	c.(1258-1260)CCT>TCT	p.P420S	HDAC9_uc003sue.2_Missense_Mutation_p.P420S|HDAC9_uc011jyd.1_Missense_Mutation_p.P420S|HDAC9_uc003sui.2_Missense_Mutation_p.P423S|HDAC9_uc003suj.2_Missense_Mutation_p.P379S|HDAC9_uc011jya.1_Missense_Mutation_p.P417S|HDAC9_uc003sua.1_Missense_Mutation_p.P398S|HDAC9_uc011jyb.1_Missense_Mutation_p.P376S|HDAC9_uc003sud.1_Missense_Mutation_p.P420S|HDAC9_uc011jyc.1_Missense_Mutation_p.P379S|HDAC9_uc003suf.1_Missense_Mutation_p.P451S|HDAC9_uc010kud.1_Missense_Mutation_p.P423S|HDAC9_uc011jye.1_Missense_Mutation_p.P392S|HDAC9_uc011jyf.1_Missense_Mutation_p.P343S|HDAC9_uc010kue.1_Missense_Mutation_p.P163S	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	420					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TCCCTTACATCCTCAGTCTCC	0.353000													17	62					0	0	0.028581	0	0
PDE1C	5137	broad.mit.edu	37	7	32109934	32109934	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:32109934G>A	uc003tcm.1	-	1	541	c.72C>T	c.(70-72)ATC>ATT	p.I24I	PDE1C_uc003tcn.1_Silent_p.I24I|PDE1C_uc003tco.1_Intron|PDE1C_uc003tcr.2_Silent_p.I24I|PDE1C_uc003tcs.2_Silent_p.I24I	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	24					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AGATTTTCTCGATCTGTTCCG	0.512000													9	74					0	0	0.008291	0	0
IKZF1	10320	broad.mit.edu	37	7	50459541	50459541	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:50459541C>T	uc003tow.3	+	8	998	c.830C>T	c.(829-831)TCT>TTT	p.S277F	IKZF1_uc003tox.3_Missense_Mutation_p.S235F|IKZF1_uc003toy.3_Missense_Mutation_p.S235F|IKZF1_uc011kck.1_Missense_Mutation_p.S190F|IKZF1_uc003toz.3_Missense_Mutation_p.S247F|IKZF1_uc010kyx.2_Intron|IKZF1_uc003tpa.3_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	277					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CGTAAGAGCTCTATGCCTCAG	0.413000			D		ALL								4	15					0	0	0.014758	0	0
POM121C	100101267	broad.mit.edu	37	7	75048176	75048176	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:75048176C>T	uc003udk.3	-	15	3752	c.2867G>A	c.(2866-2868)GGA>GAA	p.G956E		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1198	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						GGCCGCCGATCCTGGAAAGAT	0.572000													8	18					0	0	0.010729	0	0
HIP1	3092	broad.mit.edu	37	7	75174462	75174462	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:75174462A>G	uc003uds.1	-	26	2625	c.2584T>C	c.(2584-2586)TAT>CAT	p.Y862H	HIP1_uc011kfz.1_Missense_Mutation_p.Y688H	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	862	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						TTCTTGGCATAAAACTCTTTA	0.333000			T	PDGFRB	CMML								32	126					0	0	0.010818	0	0
PCLO	27445	broad.mit.edu	37	7	82538321	82538321	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:82538321G>A	uc003uhx.2	-	8	13598	c.13309C>T	c.(13309-13311)CTG>TTG	p.L4437L	PCLO_uc003uhv.2_Silent_p.L4437L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4368					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCACGACGCAGATGATAGGCT	0.458000													6	34					0	0	0.021553	0	0
DLX6	1750	broad.mit.edu	37	7	96637108	96637108	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:96637108G>A	uc003uom.2	+	3	511	c.511G>A	c.(511-513)GAA>AAA	p.E171K	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	81	Homeobox.				nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					AGAGAGAGCCGAACTGGCAGC	0.527000													5	8					0	0	0.014758	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100017492	100017492	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:100017492G>A	uc003uut.2	-	4	291	c.43C>T	c.(43-45)CCA>TCA	p.P15S	ZCWPW1_uc011kjq.1_5'Flank|ZCWPW1_uc003uur.2_5'Flank|ZCWPW1_uc003uus.2_5'UTR|ZCWPW1_uc011kjr.1_Missense_Mutation_p.P14S|ZCWPW1_uc003uuu.1_Missense_Mutation_p.P14S|ZCWPW1_uc011kjs.1_5'Flank|ZCWPW1_uc011kjt.1_Missense_Mutation_p.P14S|ZCWPW1_uc011kju.1_Missense_Mutation_p.P14S	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	15							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTCTCTTTGGTCCCTTTCCA	0.408000													7	41					0	0	0.003080	0	0
PLOD3	8985	broad.mit.edu	37	7	100856395	100856395	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:100856395G>A	uc003uyd.2	-	7	1226	c.770C>T	c.(769-771)CCC>CTC	p.P257L	PLOD3_uc010lhs.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	257					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CACCTTAGTGGGACCGTTTCC	0.602000													8	35					0	0	0.003080	0	0
SH2B2	10603	broad.mit.edu	37	7	101957790	101957790	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:101957790C>T	uc011kko.1	+	5	1497	c.1452C>T	c.(1450-1452)CTC>CTT	p.L484L		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	441	SH2.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						ACCACGGCCTCTTCGTGATCC	0.642000													6	21					0	0	0.021553	0	0
RELN	5649	broad.mit.edu	37	7	103202352	103202352	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:103202352C>T	uc003vca.2	-	35	5419	c.5259G>A	c.(5257-5259)GGG>GGA	p.G1753G	RELN_uc010liz.2_Silent_p.G1753G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1753					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGGAATCAGCCCCCACAGTGT	0.478000													5	18					0	0	0.021553	0	0
EIF3IP1	442720	broad.mit.edu	37	7	109599814	109599814	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:109599814C>T	uc003vfp.1	-	1	457	c.284G>A	c.(283-285)AGT>AAT	p.S95N		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						TTTAGAGTCACTGCAAGGGAT	0.493000													8	26					0	0	0.004482	0	0
MET	4233	broad.mit.edu	37	7	116339236	116339236	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:116339236C>T	uc003vij.2	+	2	285	c.98C>T	c.(97-99)TCC>TTC	p.S33F	MET_uc010lkh.2_Missense_Mutation_p.S33F|MET_uc011knc.1_Missense_Mutation_p.S33F|MET_uc011knd.1_Missense_Mutation_p.S33F|MET_uc011kne.1_Missense_Mutation_p.S33F|MET_uc011knf.1_Missense_Mutation_p.S33F|MET_uc011kng.1_Missense_Mutation_p.S33F|MET_uc011knh.1_Missense_Mutation_p.S33F|MET_uc011kni.1_Missense_Mutation_p.S33F|MET_uc003vii.1_Missense_Mutation_p.S52F|MET_uc010lkg.2_Missense_Mutation_p.S33F|MET_uc011kmz.1_Missense_Mutation_p.S33F|MET_uc011kna.1_Missense_Mutation_p.S33F|MET_uc011knb.1_Missense_Mutation_p.S33F	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	33	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.982_1028del47(8)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTAGCAAAGTCCGAGATGAAT	0.498000			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				10	67					0	0	0.006214	0	0
ASB15	142685	broad.mit.edu	37	7	123267311	123267311	+	Missense_Mutation	SNP	G	A	A	rs142770562	by1000genomes	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:123267311G>A	uc003vku.1	+	9	1137	c.845G>A	c.(844-846)CGA>CAA	p.R282Q	ASB15_uc003vkv.1_Missense_Mutation_p.R282Q|ASB15_uc003vkw.1_Missense_Mutation_p.R282Q	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	282					intracellular signal transduction					skin(2)|lung(1)	3						CCTATACACCGAGCTGCCTAT	0.423000													4	32					0	0	0.014758	0	0
GPR37	2861	broad.mit.edu	37	7	124386789	124386789	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:124386789G>A	uc003vli.2	-	2	2283	c.1632C>T	c.(1630-1632)GTC>GTT	p.V544V		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	544	Helical; Name=7; (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GGACTGGGGTGACACAGGACT	0.488000													13	59					0	0	0.013537	0	0
FLNC	2318	broad.mit.edu	37	7	128494692	128494692	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:128494692G>A	uc003vnz.3	+	41	7162	c.6953G>A	c.(6952-6954)CGG>CAG	p.R2318Q	FLNC_uc003voa.3_Missense_Mutation_p.R2285Q	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2318	Filamin 21.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CACAAGGTGCGGGCCGGAGGC	0.687000													6	24					0	0	0.021553	0	0
MEST	4232	broad.mit.edu	37	7	130135307	130135307	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:130135307C>T	uc003vqg.2	+	2	342	c.125C>T	c.(124-126)TCA>TTA	p.S42L	MEST_uc003vqc.2_Missense_Mutation_p.S33L|MEST_uc003vqd.2_Missense_Mutation_p.S33L|MEST_uc003vqf.2_Missense_Mutation_p.S33L|MEST_uc011kph.1_Missense_Mutation_p.S42L|MEST_uc010lmg.2_Missense_Mutation_p.S42L|uc011kpi.1_5'Flank|MIR335_hsa-mir-335|MI0000816_5'Flank	NM_002402	NP_002393	Q5EB52	MEST_HUMAN	mesoderm specific transcript isoform a	42					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)					GCCCTTCACTCATGGAAGTCT	0.557000													70	401					0	0	0.014410	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192613	132192613	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:132192613G>A	uc003vra.3	-	2	1069	c.840C>T	c.(838-840)CTC>CTT	p.L280L	PLXNA4_uc003vrc.2_Silent_p.L280L|PLXNA4_uc003vrb.2_Silent_p.L280L	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	280	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AAAGCCTCACGAGCTTGGATG	0.552000													6	35					0	0	0.003080	0	0
DENND2A	27147	broad.mit.edu	37	7	140273659	140273659	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:140273659G>A	uc010lnj.2	-	4	1540	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.F465F|DENND2A_uc003vvw.2_Silent_p.F465F|DENND2A_uc003vvx.2_Silent_p.F465F	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	465										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CAAGGTTAAAGAAAATGTCAT	0.517000													37	196					0	0	0.021022	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				16	47					0	0	0.007413	0	0
OR9A4	130075	broad.mit.edu	37	7	141619380	141619380	+	Silent	SNP	G	A	A	rs143629932		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:141619380G>A	uc003vwu.1	+	1	705	c.705G>A	c.(703-705)AGG>AGA	p.R235R		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R235R(1)		skin(1)	1	Melanoma(164;0.0171)					CTGGCCGGAGGAAATCCTTCT	0.502000													7	82					0	0	0.006214	0	0
MGAM	8972	broad.mit.edu	37	7	141762457	141762457	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:141762457T>A	uc003vwy.2	+	35	4266	c.4212T>A	c.(4210-4212)AAT>AAA	p.N1404K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1404	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TATACAACAATCCACAGAATC	0.428000													11	27					0	0	0.008291	0	0
Unknown	0	broad.mit.edu	37	7	142001108	142001108	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:142001108C>T	uc011kro.1	+	2	245	c.200C>T	c.(199-201)TCC>TTC	p.S67F						SubName: Full=V_segment translation product; Flags: Fragment;																		TTTCTGGTTTCCTTTTATAAT	0.398000													4	19					0	0	0.014758	0	0
OR2F2	135948	broad.mit.edu	37	7	143633111	143633111	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:143633111C>T	uc011ktv.1	+	1	786	c.786C>T	c.(784-786)CCC>CCT	p.P262P		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					ACATCCAGCCCCACTCTGGTC	0.488000													12	69					0	0	0.020292	0	0
OR2A5	393046	broad.mit.edu	37	7	143747706	143747706	+	Missense_Mutation	SNP	C	T	T	rs149614119	by1000genomes	TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:143747706C>T	uc011ktw.1	+	1	212	c.212C>T	c.(211-213)TCG>TTG	p.S71L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					ATTGATATTTCGTATGCTTCC	0.483000													15	63					0	0	0.020292	0	0
OR2A5	393046	broad.mit.edu	37	7	143747855	143747855	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:143747855G>A	uc011ktw.1	+	1	361	c.361G>A	c.(361-363)GAT>AAT	p.D121N		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					GATGTCCTACGATCGGTACAT	0.468000													70	112					0	0	0.014410	0	0
OR2A25	392138	broad.mit.edu	37	7	143771818	143771818	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:143771818G>A	uc011ktx.1	+	1	506	c.506G>A	c.(505-507)GGA>GAA	p.G169E		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TCCTTCTGTGGACCCCAGAAA	0.448000													25	125					0	0	0.006320	0	0
GALNT11	63917	broad.mit.edu	37	7	151815816	151815816	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr7:151815816G>A	uc010lqg.1	+	10	1736	c.1506G>A	c.(1504-1506)CAG>CAA	p.Q502Q	GALNT11_uc011kvm.1_Silent_p.Q421Q|GALNT11_uc003wku.2_Silent_p.Q502Q|GALNT11_uc003wkw.1_3'UTR	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	502	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GCCCAAGTCAGAAGGGAGGTC	0.567000													4	34					0	0	0.014758	0	0
XPO7	23039	broad.mit.edu	37	8	21844783	21844783	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:21844783C>T	uc003xaa.3	+	14	1811	c.1709C>T	c.(1708-1710)TCT>TTT	p.S570F	XPO7_uc010lti.2_Missense_Mutation_p.S579F|XPO7_uc010ltk.2_Missense_Mutation_p.S571F	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	570					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CAGAAATCCTCTAAGGTAACA	0.473000													16	50					0	0	0.006122	0	0
ADAM7	8756	broad.mit.edu	37	8	24350082	24350082	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:24350082G>A	uc003xeb.2	+	15	1740	c.1627G>A	c.(1627-1629)GAA>AAA	p.E543K	ADAM7_uc003xec.2_Missense_Mutation_p.E315K	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	543	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CAAAAACAAGGAAAACAGATT	0.368000													15	105					0	0	0.004990	0	0
ADAM2	2515	broad.mit.edu	37	8	39682369	39682369	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:39682369C>T	uc003xnj.2	-	4	311	c.236G>A	c.(235-237)GGA>GAA	p.G79E	ADAM2_uc003xnk.2_Missense_Mutation_p.G79E|ADAM2_uc011lck.1_Missense_Mutation_p.G79E|ADAM2_uc003xnl.2_Missense_Mutation_p.G79E	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	79					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTTCATAATTCCTGTGCCACT	0.294000													10	16					0	0	0.008291	0	0
ANK1	286	broad.mit.edu	37	8	41573301	41573301	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:41573301C>T	uc003xok.2	-	14	1555	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.E491K|ANK1_uc003xoj.2_Missense_Mutation_p.E491K|ANK1_uc003xol.2_Missense_Mutation_p.E491K|ANK1_uc003xom.2_Missense_Mutation_p.E524K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	491	ANK 14.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCGTTATTTTCCAGCAGGAGC	0.572000													11	101					0	0	0.020292	0	0
MYST3	7994	broad.mit.edu	37	8	41798675	41798675	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:41798675G>A	uc010lxb.2	-	16	3268	c.2724C>T	c.(2722-2724)GCC>GCT	p.A908A	MYST3_uc010lxc.2_Silent_p.A908A|MYST3_uc003xon.3_Silent_p.A908A	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	908					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			GTTCCTGGGTGGCTTCTGATT	0.493000													10	66					0	0	0.008291	0	0
PENK	5179	broad.mit.edu	37	8	57354176	57354177	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:57354176_57354177GG>AA	uc003xsz.2	-	2	539_540	c.458_459CC>TT	c.(457-459)TCC>TTT	p.S153F	PENK_uc003xta.3_Missense_Mutation_p.S153F	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	153					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCAGGTCTGAGGAATTGGCCAG	0.530000													30	86					0	0	0.004672	0	0
CHD7	55636	broad.mit.edu	37	8	61735191	61735191	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:61735191C>T	uc003xue.2	+	12	3564	c.3087C>T	c.(3085-3087)CCC>CCT	p.P1029P	CHD7_uc003xuf.2_Silent_p.P142P	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1029	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CCACAATCCCCAACTGGGAAA	0.423000													28	174					0	0	0.013726	0	0
CLVS1	157807	broad.mit.edu	37	8	62289186	62289186	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:62289186C>T	uc003xuh.2	+	3	802	c.478C>T	c.(478-480)CGT>TGT	p.R160C	CLVS1_uc003xug.2_Silent_p.F158F|CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Missense_Mutation_p.R160C	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	160	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						AGACATCCTTCGTGCCATCCT	0.458000													18	78					0	0	0.007413	0	0
VPS13B	157680	broad.mit.edu	37	8	100654325	100654325	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:100654325C>T	uc003yiv.2	+	34	5693	c.5582C>T	c.(5581-5583)TCA>TTA	p.S1861L	VPS13B_uc003yiw.2_Missense_Mutation_p.S1836L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1861					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAATCGAAATCACAAGAACAG	0.338000													11	59					0	0	0.008291	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110448612	110448612	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:110448612C>T	uc003yne.2	+	30	3655	c.3551C>T	c.(3550-3552)TCA>TTA	p.S1184L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1184	Extracellular (Potential).|IPT/TIG 5.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AATGAAAATTCAAAGGTATTA	0.348000										HNSCC(38;0.096)			13	64					0	0	0.016723	0	0
ADCY8	114	broad.mit.edu	37	8	131880139	131880139	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:131880139G>A	uc003ytd.3	-	9	2419	c.2163C>T	c.(2161-2163)ATC>ATT	p.I721I	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	721	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATAGAAGAACGATAAATGCAC	0.348000										HNSCC(32;0.087)			5	49					0	0	0.021553	0	0
ADCY8	114	broad.mit.edu	37	8	131896878	131896878	+	Missense_Mutation	SNP	C	T	T	rs145360233		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr8:131896878C>T	uc003ytd.3	-	8	2297	c.2041G>A	c.(2041-2043)GAT>AAT	p.D681N	ADCY8_uc010mds.2_Missense_Mutation_p.D681N	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	681	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.D681N(1)		skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTCAATTTATCGCCACTCCGC	0.463000										HNSCC(32;0.087)			49	77					0	0	0.014410	0	0
PTPRD	5789	broad.mit.edu	37	9	8521304	8521304	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:8521304C>T	uc003zkk.2	-	19	1645	c.934G>A	c.(934-936)GAA>AAA	p.E312K	PTPRD_uc003zkp.2_Missense_Mutation_p.E312K|PTPRD_uc003zkq.2_Missense_Mutation_p.E312K|PTPRD_uc003zkr.2_Missense_Mutation_p.E306K|PTPRD_uc003zks.2_Missense_Mutation_p.E302K|PTPRD_uc003zkl.2_Missense_Mutation_p.E312K|PTPRD_uc003zkm.2_Missense_Mutation_p.E299K|PTPRD_uc003zkn.2_Missense_Mutation_p.E312K|PTPRD_uc003zko.2_Missense_Mutation_p.E309K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	312	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCTATTGCTTCAATGACACCC	0.418000										TSP Lung(15;0.13)			9	34					0	0	0.006214	0	0
IFNA5	3442	broad.mit.edu	37	9	21305033	21305033	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:21305033G>A	uc011lnh.1	-	1	223	c.223C>T	c.(223-225)CAA>TAA	p.Q75*		NM_002169	NP_002160	P01569	IFNA5_HUMAN	interferon, alpha 5 precursor	75					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			ovary(1)	1				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GAGATGGCTTGAGCCTTCTGG	0.473000													33	72					0	0	0.015359	0	0
PCSK5	5125	broad.mit.edu	37	9	78641900	78641900	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:78641900G>A	uc004ajz.2	+	5	1117	c.579G>A	c.(577-579)GTG>GTA	p.V193V	PCSK5_uc004ajy.2_Silent_p.V193V|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	193	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GTTGCGACGTGAATGGGAATG	0.512000													8	34					0	0	0.006214	0	0
ROR2	4920	broad.mit.edu	37	9	94538041	94538041	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:94538041G>A	uc004arj.1	-	2	356	c.157C>T	c.(157-159)CCG>TCG	p.P53S	ROR2_uc004ari.1_5'UTR|ROR2_uc004ark.2_Missense_Mutation_p.P53S	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	53	Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GTTGGAATCGGGCCGTCCTGC	0.527000											OREG0019308	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	18					0	0	0.021553	0	0
PAPPA	5069	broad.mit.edu	37	9	118949536	118949536	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:118949536C>T	uc004bjn.2	+	2	900	c.519C>T	c.(517-519)TCC>TCT	p.S173S	PAPPA_uc011lxp.1_5'UTR|PAPPA_uc011lxq.1_5'UTR	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	173					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ACTTTTTCTCCTTGAAGACAG	0.527000													9	47					0	0	0.004482	0	0
PAPPA	5069	broad.mit.edu	37	9	118949853	118949853	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr9:118949853C>T	uc004bjn.2	+	2	1217	c.836C>T	c.(835-837)ACT>ATT	p.T279I	PAPPA_uc011lxp.1_Missense_Mutation_p.T72I|PAPPA_uc011lxq.1_Missense_Mutation_p.T72I	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	279	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GGCGCCCACACTGCTCTACCT	0.557000													20	61					0	0	0.014323	0	0
CSF2RA	1438	broad.mit.edu	37	X	1401651	1401651	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:1401651C>T	uc010nct.2	+	4	377	c.55C>T	c.(55-57)CTC>TTC	p.L19F	CSF2RA_uc011mhb.1_Missense_Mutation_p.L19F|CSF2RA_uc004cpq.2_Missense_Mutation_p.L19F|CSF2RA_uc004cpn.2_Missense_Mutation_p.L19F|CSF2RA_uc004cpo.2_Missense_Mutation_p.L19F|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Missense_Mutation_p.L19F|CSF2RA_uc010ncv.2_Missense_Mutation_p.L19F|CSF2RA_uc004cpr.2_Missense_Mutation_p.L19F	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	19						extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CCCAGCATTCCTCCTGATCCC	0.522000													54	166					0	0	0.014410	0	0
MXRA5	25878	broad.mit.edu	37	X	3242438	3242438	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:3242438C>T	uc004crg.3	-	5	1445	c.1288G>A	c.(1288-1290)GAA>AAA	p.E430K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	430						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATGACCCATTCTGGTTCTGCA	0.498000													23	40					0	0	0.021523	0	0
CXorf22	170063	broad.mit.edu	37	X	35959408	35959408	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:35959408C>T	uc004ddj.2	+	3	469	c.410C>T	c.(409-411)CCA>CTA	p.P137L	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	137										large_intestine(1)|lung(1)|ovary(1)	3						AGGTTGATTCCATCCTGTCAA	0.348000													11	17					0	0	0.010729	0	0
SYTL5	94122	broad.mit.edu	37	X	37969626	37969626	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:37969626G>A	uc004ddu.2	+	14	2021	c.1487G>A	c.(1486-1488)TGG>TAG	p.W496*	SYTL5_uc004ddv.2_Nonsense_Mutation_p.W496*|SYTL5_uc004ddx.2_Nonsense_Mutation_p.W518*	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	496	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CTCTCAGTCTGGCACTATGAT	0.448000													12	25					0	0	0.013537	0	0
ODZ1	10178	broad.mit.edu	37	X	124029836	124029836	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:124029836C>T	uc004euj.2	-	2	536	c.472G>A	c.(472-474)GAA>AAA	p.E158K	ODZ1_uc011muj.1_Missense_Mutation_p.E158K|ODZ1_uc010nqy.2_Missense_Mutation_p.E158K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	158	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTACCATTTTCCCCATCAGAC	0.408000													19	41					0	0	0.007413	0	0
IGSF1	3547	broad.mit.edu	37	X	130411013	130411013	+	Silent	SNP	G	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:130411013G>A	uc004ewd.2	-	14	2746	c.2508C>T	c.(2506-2508)ATC>ATT	p.I836I	IGSF1_uc004ewe.3_Silent_p.I830I|IGSF1_uc004ewf.2_Silent_p.I816I	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	836	Extracellular (Potential).|Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CCACCGAAATGATTAGAAAGT	0.498000													61	97					0	0	0.014410	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135829724	135829724	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:135829724C>T	uc004fab.2	-	3	739	c.277G>A	c.(277-279)GGG>AGG	p.G93R	ARHGEF6_uc011mwd.1_5'UTR|ARHGEF6_uc011mwe.1_5'UTR	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	93	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					AAATTGACCCCTGAATAAAGG	0.378000													12	27					0	0	0.016723	0	0
GPR50	9248	broad.mit.edu	37	X	150348250	150348250	+	Silent	SNP	C	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:150348250C>T	uc010ntg.1	+	2	330	c.195C>T	c.(193-195)ATC>ATT	p.I65I	uc004fes.1_5'Flank|GPR50_uc011myc.1_Silent_p.I65I	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	65	Helical; Name=2; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGCAACATCTTCGTGGTCA	0.488000													71	131					0	0	0.014410	0	0
F8	2157	broad.mit.edu	37	X	154194293	154194293	+	Silent	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:154194293T>C	uc004fmt.2	-	9	1566	c.1395A>G	c.(1393-1395)TCA>TCG	p.S465S		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	465	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CCAAGATTCCTGATTCATGCT	0.408000													3	58					0	0	0.004672	0	0
BRCC3	79184	broad.mit.edu	37	X	154344368	154344368	+	Silent	SNP	T	C	C			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:154344368T>C	uc004fna.2	+	9	753	c.660T>C	c.(658-660)CCT>CCC	p.P220P	BRCC3_uc004fnb.2_Silent_p.P195P	NM_024332	NP_077308	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	220					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(3)|ovary(1)|large_intestine(1)|breast(1)	6	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATATTGTACCTCATGTCACTA	0.458000													2	12					0	0	0.004672	0	0
SLC16A4	9122	broad.mit.edu	37	1	110906426	110906427	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr1:110906426_110906427insA	uc001dzo.1	-	9	1607_1608	c.1425_1426insT	c.(1423-1428)TTTGTAfs	p.F475fs	SLC16A4_uc009wfs.1_Frame_Shift_Ins_p.F427fs|SLC16A4_uc001dzp.1_Frame_Shift_Ins_p.F307fs|SLC16A4_uc010ovy.1_Frame_Shift_Ins_p.F413fs|SLC16A4_uc001dzq.1_Frame_Shift_Ins_p.F245fs|SLC16A4_uc010ovz.1_Frame_Shift_Ins_p.L372fs	NM_004696	NP_004687	O15374	MOT5_HUMAN	solute carrier family 16, member 4	475_476	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			ovary(3)	3		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)	GCCAATGGTACAAAAAAAAAGG	0.391													7	40	---	---	---	---					
ALS2CR11	151254	broad.mit.edu	37	2	202430447	202430450	+	Splice_Site	DEL	TTTA	-	-	rs35855277		TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr2:202430447_202430450delTTTA	uc002uye.2	-	9	1025	c.977_splice	c.e9+1	p.R326_splice	ALS2CR11_uc002uyf.2_Splice_Site_p.R326_splice|ALS2CR11_uc010fti.2_Splice_Site_p.R326_splice	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)											large_intestine(1)|ovary(1)|skin(1)	3						tttttttttttttACCTTTCCCGG	0.368													2	4	---	---	---	---					
IFNGR2	3460	broad.mit.edu	37	21	34799292	34799292	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr21:34799292delT	uc002yrp.3	+	4	1162	c.514delT	c.(514-516)TTTfs	p.F172fs	IFNGR2_uc002yrq.3_Frame_Shift_Del_p.F191fs|IFNGR2_uc010gma.2_Frame_Shift_Del_p.F93fs|IFNGR2_uc002yrr.3_Frame_Shift_Del_p.F93fs	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	172	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	CTCCACGGCCTTTTTTTGTTA	0.458													7	375	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184040958	184040959	+	Frame_Shift_Ins	INS	-	T	T			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chr3:184040958_184040959insT	uc003fnp.2	+	14	2215_2216	c.2017_2018insT	c.(2017-2019)CTTfs	p.L673fs	EIF4G1_uc003fno.1_Frame_Shift_Ins_p.L614fs|EIF4G1_uc010hxw.1_Frame_Shift_Ins_p.L509fs|EIF4G1_uc003fnt.2_Frame_Shift_Ins_p.L384fs|EIF4G1_uc003fnq.2_Frame_Shift_Ins_p.L586fs|EIF4G1_uc003fnr.2_Frame_Shift_Ins_p.L509fs|EIF4G1_uc010hxx.2_Frame_Shift_Ins_p.L680fs|EIF4G1_uc003fns.2_Frame_Shift_Ins_p.L633fs|EIF4G1_uc010hxy.2_Frame_Shift_Ins_p.L680fs|EIF4G1_uc003fnv.3_Frame_Shift_Ins_p.L673fs|EIF4G1_uc003fnu.3_Frame_Shift_Ins_p.L673fs|EIF4G1_uc003fnw.2_Frame_Shift_Ins_p.L680fs|EIF4G1_uc003fnx.2_Frame_Shift_Ins_p.L477fs|EIF4G1_uc003fny.3_Frame_Shift_Ins_p.L477fs|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	673	MIF4G.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTTTGCCAACCTTGGCCGGACA	0.614													36	109	---	---	---	---					
PSMD10	5716	broad.mit.edu	37	X	107331269	107331269	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A2J7-06A-11D-A196-08	TCGA-D3-A2J7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	a6f33a5e-136c-44c1-9040-20b53dd002e1	b115478c-52a9-47f1-9fbc-89d234525e73	g.chrX:107331269delG	uc004enp.1	-	3	372	c.274delC	c.(274-276)CTTfs	p.L92fs	PSMD10_uc004enq.1_Frame_Shift_Del_p.L92fs|PSMD10_uc010nph.1_Intron	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	92	Interaction with RELA.|ANK 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						TTTCCCAGAAGGGCTTTTACA	0.453													34	45	---	---	---	---					
