Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MORN1	79906	broad.mit.edu	37	1	2268180	2268180	+	Silent	SNP	G	A	A	rs150260968	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:2268180G>A	uc001ajb.1	-	11	1167	c.1146C>T	c.(1144-1146)TTC>TTT	p.F382F	MORN1_uc009vld.2_Silent_p.F358F	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	382										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		CCAGGAACAGGAAGGGGTGGT	0.682													13	10					0	0	0.00136819	0	0
PANK4	55229	broad.mit.edu	37	1	2445459	2445459	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:2445459G>A	uc001ajm.1	-	12	1566	c.1557C>T	c.(1555-1557)TTC>TTT	p.F519F	PANK4_uc010nza.1_Silent_p.F480F	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	519					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AGGGATCCGGGAAGTTGAACT	0.652													59	55					0	0	0.000781405	0	0
PRDM16	63976	broad.mit.edu	37	1	3319548	3319548	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:3319548C>T	uc001akf.2	+	6	950	c.870C>T	c.(868-870)TTC>TTT	p.F290F	PRDM16_uc001akc.2_Silent_p.F290F|PRDM16_uc001akd.2_Silent_p.F290F|PRDM16_uc001ake.2_Silent_p.F290F|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	290	C2H2-type 2.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCGGATGTTCCCCAACAAGT	0.453			T	EVI1	MDS|AML								9	11					0	0	0.000442599	0	0
MST1P2	11209	broad.mit.edu	37	1	16974277	16974277	+	RNA	SNP	A	C	C	rs151151026	by1000genomes	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:16974277A>C	uc009vow.2	+	5		c.1087A>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Splice_Site|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Splice_Site|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Splice_Site|MST1P2_uc001azm.3_Splice_Site					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GGTCCATCTAAGGGTCCGAGG	0.657													3	12					0	0	0.000602214	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18808424	18808424	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:18808424C>T	uc001bax.2	+	1	1001	c.949C>T	c.(949-951)CCA>TCA	p.P317S	KLHDC7A_uc009vpg.2_Missense_Mutation_p.P99S	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	317						integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GACTGAGGTTCCATCCCCTAG	0.647													12	11					0	0	0.00136819	0	0
PHC2	1912	broad.mit.edu	37	1	33797949	33797949	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:33797949G>A	uc001bxg.1	-	10	1869	c.1815C>T	c.(1813-1815)TTC>TTT	p.F605F	PHC2_uc001bxh.1_Silent_p.F577F|PHC2_uc009vuh.1_Silent_p.F606F|PHC2_uc001bxe.1_Silent_p.F70F|PHC2_uc001bxf.1_Silent_p.F20F	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	605					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TCTCAGGCAGGAACCCCTGTG	0.582													39	50					0	0	0.00148497	0	0
CSMD2	114784	broad.mit.edu	37	1	34087804	34087804	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:34087804G>A	uc001bxn.1	-	37	5699	c.5670C>T	c.(5668-5670)ATC>ATT	p.I1890I	CSMD2_uc001bxm.1_Silent_p.I1930I|CSMD2_uc001bxo.1_Silent_p.I803I	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1890	CUB 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CAGATACGCTGATATCTGAGT	0.517													58	51					0	0	0.000781405	0	0
EIF2C1	26523	broad.mit.edu	37	1	36358768	36358768	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:36358768C>T	uc001bzl.2	+	4	614	c.401C>T	c.(400-402)GCC>GTC	p.A134V	EIF2C1_uc001bzk.2_Missense_Mutation_p.A59V|EIF2C1_uc009vuy.2_5'Flank	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	134					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAGTGGCTAGCCATTGTGAGC	0.557													14	12					0	0	0.000219431	0	0
GRIK3	2899	broad.mit.edu	37	1	37267569	37267569	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:37267569C>T	uc001caz.2	-	16	2778	c.2643G>A	c.(2641-2643)CAG>CAA	p.Q881Q		NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	881	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TCATGGGAGGCTGAGGCTTGT	0.592													10	9					0	0	0.000673444	0	0
FHL3	2275	broad.mit.edu	37	1	38465046	38465046	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:38465046G>A	uc001ccj.2	-	2	126	c.39C>T	c.(37-39)TCC>TCT	p.S13S	FHL3_uc001cck.2_Silent_p.S13S|FHL3_uc001ccl.2_Silent_p.S13S|FHL3_uc001ccm.2_Intron|FHL3_uc009vvl.1_Silent_p.S13S	NM_004468	NP_004459	Q13643	FHL3_HUMAN	four and a half LIM domains 3	13	C4-type (Potential).				muscle organ development		zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GTCCATACAGGGACTCGTTGC	0.542													4	10					0	0	0.000602214	0	0
HIVEP3	59269	broad.mit.edu	37	1	42049328	42049328	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:42049328G>A	uc001cgz.3	-	4	2354	c.1141C>T	c.(1141-1143)CTG>TTG	p.L381L	HIVEP3_uc001cha.3_Silent_p.L381L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	381	Ser-rich.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CCTGGGCTCAGAAACGCCTGC	0.567													11	41					0	0	0.000673444	0	0
ERMAP	114625	broad.mit.edu	37	1	43296563	43296563	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:43296563C>T	uc001cic.1	+	4	480	c.210C>T	c.(208-210)TTC>TTT	p.F70F	ERMAP_uc010ojw.1_Silent_p.F131F|ERMAP_uc001cid.1_Intron|ERMAP_uc001cie.1_Silent_p.F70F|ERMAP_uc001cif.1_5'UTR	NM_001017922	NP_001017922	Q96PL5	ERMAP_HUMAN	erythroblast membrane-associated protein	70	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGTCCCCATTCCCGCAGCGCT	0.622													9	7					0	0	0.000673444	0	0
NEGR1	257194	broad.mit.edu	37	1	72163761	72163761	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:72163761C>T	uc001dfw.2	-	4	697	c.597G>A	c.(595-597)GGG>GGA	p.G199G	NEGR1_uc001dfv.2_Silent_p.G71G|NEGR1_uc010oqs.1_Intron	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	199	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		ATTCATATTCCCCAGCCTGGT	0.368													28	21					0	0	0.00127121	0	0
CLCA3P	9629	broad.mit.edu	37	1	87104551	87104551	+	RNA	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:87104551C>T	uc010osh.1	+	5		c.586C>T				NR_024604				Synthetic construct DNA, clone: pF1KB7225, Homo sapiens CLCA3 gene for chloride channel, calcium activated, family member 3, without stop codon, in Flexi system.												0						ATGTTCCACTCGTATTACTGT	0.378													11	7					0	0	0.00136819	0	0
ABCD3	5825	broad.mit.edu	37	1	94964161	94964161	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:94964161C>T	uc001dqn.3	+	17	1492	c.1390C>T	c.(1390-1392)CGA>TGA	p.R464*	ABCD3_uc010oto.1_Nonsense_Mutation_p.R488*|ABCD3_uc010otp.1_Nonsense_Mutation_p.R391*|ABCD3_uc009wdr.2_Nonsense_Mutation_p.R354*|ABCD3_uc001dqo.3_Nonsense_Mutation_p.R152*	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	464	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTTTCAGGTTCGATCTGGGGC	0.338													9	21					0	0	0.000978159	0	0
SLC6A17	388662	broad.mit.edu	37	1	110740760	110740760	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:110740760C>T	uc009wfq.2	+	12	2339	c.1878C>T	c.(1876-1878)GTC>GTT	p.V626V		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	626	Helical; Name=12; (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CCCTCATCGTCGTGGCGACGC	0.637													8	6					0	0	0.000274275	0	0
KCNC4	3749	broad.mit.edu	37	1	110765757	110765757	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:110765757A>G	uc001dzh.2	+	2	907	c.850A>G	c.(850-852)ATC>GTC	p.I284V	KCNC4_uc001dzf.2_Missense_Mutation_p.I284V|KCNC4_uc009wfr.2_Missense_Mutation_p.I284V|KCNC4_uc001dzg.2_Missense_Mutation_p.I284V|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	284	Helical; Name=Segment S2; (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCTGACCTACATCGAGGGCGT	0.567													35	36					0	0	0.000589545	0	0
GJA5	2702	broad.mit.edu	37	1	147230415	147230415	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:147230415C>T	uc001eps.1	-	2	1073	c.932G>A	c.(931-933)GGT>GAT	p.G311D	GJA5_uc001ept.1_Missense_Mutation_p.G311D	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	311	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTGGATGAAACCTTCCCCAGG	0.517													35	101					0	0	0.000491102	0	0
SEMA6C	10500	broad.mit.edu	37	1	151109048	151109048	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:151109048C>A	uc001ewu.2	-	12	1282	c.982G>T	c.(982-984)GGC>TGC	p.G328C	SEMA6C_uc001ewv.2_Missense_Mutation_p.G328C|SEMA6C_uc001eww.2_Missense_Mutation_p.G288C|SEMA6C_uc010pcq.1_Missense_Mutation_p.G328C	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	328	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACGGCAGAGCCAGGGATGCTG	0.552													23	164					4.26978e-12	2.40445e-11	0.00047179	1	0
NTRK1	4914	broad.mit.edu	37	1	156843583	156843583	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:156843583G>A	uc001fqh.1	+	8	1065	c.1009G>A	c.(1009-1011)GCC>ACC	p.A337T	NTRK1_uc001fqf.1_Missense_Mutation_p.A307T|NTRK1_uc009wsi.1_Missense_Mutation_p.A42T|NTRK1_uc001fqi.1_Missense_Mutation_p.A337T|NTRK1_uc009wsk.1_Missense_Mutation_p.A337T	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	337	Ig-like C2-type 2.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGAGCCGGCAGCCAATGAGAC	0.632			T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			9	11					0	0	0.00136819	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156918202	156918202	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:156918202G>A	uc001fqo.2	-	22	2934	c.1894C>T	c.(1894-1896)CGC>TGC	p.R632C	ARHGEF11_uc010phu.1_Missense_Mutation_p.R48C|ARHGEF11_uc001fqn.2_Missense_Mutation_p.R672C|ARHGEF11_uc001fqp.1_Missense_Mutation_p.R151C	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	632					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTGCGAGAGCGGGGCACGTTC	0.622													16	69					0	0	0.000422831	0	0
CD5L	922	broad.mit.edu	37	1	157805893	157805893	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:157805893C>T	uc001frk.3	-	3	251	c.108G>A	c.(106-108)CGG>CGA	p.R36R		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	36	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCACCTCCACCCGCCCTTCAC	0.632													21	58					0	0	0.00152264	0	0
CD1B	910	broad.mit.edu	37	1	158299806	158299806	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:158299806G>A	uc001frx.2	-	3	551	c.443C>T	c.(442-444)TCA>TTA	p.S148L	CD1B_uc001frw.2_Missense_Mutation_p.S41L	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	148	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					AGGCACACATGAAGCATTCTT	0.478													64	141					0	0	0.000781405	0	0
CD1E	913	broad.mit.edu	37	1	158325195	158325195	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:158325195C>T	uc001fse.2	+	3	700	c.461C>T	c.(460-462)TCC>TTC	p.S154F	CD1E_uc010pid.1_Missense_Mutation_p.S152F|CD1E_uc010pie.1_Missense_Mutation_p.S55F|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.S154F|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.S154F|CD1E_uc001fry.2_Missense_Mutation_p.S154F|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.S154F|CD1E_uc009wsv.2_Missense_Mutation_p.S55F|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	154					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CAAGGAATTTCCTGGGAGCCA	0.448													21	114					0	0	0.000229342	0	0
APCS	325	broad.mit.edu	37	1	159558215	159558215	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:159558215G>T	uc001ftv.2	+	2	485	c.389G>T	c.(388-390)GGG>GTG	p.G130V		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	130	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					TGGATCAATGGGACACCTTTG	0.483													10	62					6.40141e-05	0.000357094	0.000978159	1	0
KCNJ9	3765	broad.mit.edu	37	1	160054185	160054185	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:160054185G>A	uc001fuy.1	+	2	607	c.365G>A	c.(364-366)GGC>GAC	p.G122D		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	122	Selectivity filter (By similarity).				synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACCACCATCGGCTACGGGCAC	0.657													8	35					0	0	0.000157383	0	0
ITLN1	55600	broad.mit.edu	37	1	160850449	160850449	+	Missense_Mutation	SNP	G	A	A	rs147618489	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:160850449G>A	uc001fxc.2	-	6	730	c.614C>T	c.(613-615)CCG>CTG	p.P205L		NM_017625	NP_060095	Q8WWA0	ITLN1_HUMAN	intelectin precursor	205	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)	7	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AGGGATCACCGGGCCGTTGTC	0.438													62	136					0	0	0.000781405	0	0
NOS1AP	9722	broad.mit.edu	37	1	162325117	162325117	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:162325117G>A	uc001gbv.2	+	7	1123	c.736G>A	c.(736-738)GAA>AAA	p.E246K	NOS1AP_uc010pkr.1_Missense_Mutation_p.E241K|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Missense_Mutation_p.E241K	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	246					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			TGTAGGGAAGGAAGGAGGCTC	0.557													24	92					0	0	0.000878237	0	0
FAM5B	57795	broad.mit.edu	37	1	177226401	177226401	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:177226401G>A	uc001glf.2	+	4	862	c.550G>A	c.(550-552)GGG>AGG	p.G184R	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Missense_Mutation_p.G79R	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	184						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						CGGGGGCAGTGGGAACAGCAC	0.552													26	38					0	0	0.00106085	0	0
SOAT1	6646	broad.mit.edu	37	1	179316752	179316752	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:179316752C>T	uc001gml.2	+	12	1198	c.1135C>T	c.(1135-1137)CTT>TTT	p.L379F	SOAT1_uc010pni.1_Missense_Mutation_p.L314F|SOAT1_uc001gmm.2_Missense_Mutation_p.L321F|SOAT1_uc010pnj.1_Missense_Mutation_p.L115F|SOAT1_uc010pnk.1_Missense_Mutation_p.L314F	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	379	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GATTCTCTTCCTTACTTTTTT	0.333													42	55					0	0	0.000509022	0	0
FAM129A	116496	broad.mit.edu	37	1	184764653	184764653	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:184764653C>T	uc001gra.2	-	14	2439	c.2245G>A	c.(2245-2247)GAA>AAA	p.E749K	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	749	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						GGCTCTTTTTCCTCTTCTTCT	0.562													24	129					0	0	0.000586117	0	0
KIF21B	23046	broad.mit.edu	37	1	200972894	200972894	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:200972894G>A	uc001gvs.1	-	8	1349	c.1032C>T	c.(1030-1032)ATC>ATT	p.I344I	KIF21B_uc001gvr.1_Silent_p.I344I|KIF21B_uc009wzl.1_Silent_p.I344I|KIF21B_uc010ppn.1_Silent_p.I344I|KIF21B_uc001gvt.1_Silent_p.I202I	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	344					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TCACACAGGCGATCATGATGG	0.567													12	56					0	0	0.000151284	0	0
CACNA1S	779	broad.mit.edu	37	1	201061138	201061138	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:201061138C>T	uc001gvv.2	-	4	730	c.503G>A	c.(502-504)CGA>CAA	p.R168Q		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	168	Helical; Name=S4 of repeat I; (Potential).|I.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTGAGCACTCGGAAGGCTCT	0.602													10	34					0	0	0.000442599	0	0
CHIT1	1118	broad.mit.edu	37	1	203192347	203192347	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:203192347C>T	uc001gzn.2	-	6	617	c.521G>A	c.(520-522)GGG>GAG	p.G174E	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_Intron|CHIT1_uc009xal.1_5'UTR|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.G165E	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	174					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						GCGTTCCTTCCCTGAGGTCTG	0.602													35	76					0	0	0.000814825	0	0
ATP2B4	493	broad.mit.edu	37	1	203669940	203669940	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:203669940G>A	uc001gzw.2	+	6	1674	c.790G>A	c.(790-792)GAA>AAA	p.E264K	ATP2B4_uc001gzv.2_Missense_Mutation_p.E264K|ATP2B4_uc009xaq.2_Missense_Mutation_p.E264K	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	264	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CCATGTCATGGAAGGTTCTGG	0.458													6	67					0	0	8.12818e-05	0	0
CDK18	5129	broad.mit.edu	37	1	205493436	205493436	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:205493436G>A	uc001hcr.2	+	4	659	c.440G>A	c.(439-441)AGC>AAC	p.S147N	CDK18_uc009xbl.1_RNA|CDK18_uc010pri.1_Silent_p.E137E|CDK18_uc001hcp.2_Missense_Mutation_p.S117N|CDK18_uc001hcq.2_Missense_Mutation_p.S117N|CDK18_uc010prj.1_Missense_Mutation_p.S28N|CDK18_uc001hcs.2_Missense_Mutation_p.S28N|CDK18_uc009xbm.1_Missense_Mutation_p.S28N	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	115							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						CAGATGGAGAGCCCAGATCTG	0.617											OREG0014156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	102					0	0	0.000586117	0	0
PM20D1	148811	broad.mit.edu	37	1	205814641	205814641	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:205814641C>T	uc001hdj.2	-	3	346	c.301G>A	c.(301-303)GTG>ATG	p.V101M	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	101						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TACTCTTCCACGACTTCATGC	0.507													40	47					0	0	0.000437636	0	0
SLC26A9	115019	broad.mit.edu	37	1	205895697	205895698	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:205895697_205895698GG>AA	uc001hdq.2	-	12	1468_1469	c.1354_1355CC>TT	c.(1354-1356)CCC>TTC	p.P452F	SLC26A9_uc001hdo.2_Missense_Mutation_p.P120F|SLC26A9_uc001hdp.2_Missense_Mutation_p.P452F	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	452						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGGTAGTAGGGGTCGGTGAGT	0.584													30	66					0	0	6.4e-05	0	0
IKBKE	9641	broad.mit.edu	37	1	206653840	206653840	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:206653840C>T	uc001hdz.1	+	13	1759	c.1391C>T	c.(1390-1392)TCC>TTC	p.S464F	IKBKE_uc009xbv.1_Missense_Mutation_p.S464F|IKBKE_uc001hea.1_Missense_Mutation_p.S379F	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	464					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					GCAAGGACATCCCTCCTCTAC	0.617													9	12					0	0	0.000274275	0	0
C1orf227	149643	broad.mit.edu	37	1	213009387	213009387	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:213009387C>T	uc001hjq.2	-	2	213	c.105G>A	c.(103-105)GTG>GTA	p.V35V		NM_001024601	NP_001019772	Q537H7	CA227_HUMAN	hypothetical protein LOC149643	35											0						TGCTTCGTTCCACCAAGCAGT	0.418													30	150					0	0	0.000339439	0	0
SUSD4	55061	broad.mit.edu	37	1	223396907	223396907	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:223396907G>A	uc001hnx.2	-	7	1762	c.1128C>T	c.(1126-1128)CTC>CTT	p.L376L	SUSD4_uc001hny.3_Silent_p.L376L|SUSD4_uc010puw.1_Silent_p.L216L	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	376	Cytoplasmic (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		CATAGGACGGGAGCATGACGG	0.617													8	9					0	0	0.000157383	0	0
NVL	4931	broad.mit.edu	37	1	224473799	224473799	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:224473799G>C	uc001hok.2	-	15	1871	c.1828C>G	c.(1828-1830)CTT>GTT	p.L610V	NVL_uc001hol.2_Missense_Mutation_p.L504V|NVL_uc010pvd.1_Missense_Mutation_p.L519V|NVL_uc010pve.1_Missense_Mutation_p.L421V|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	610						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		ACCAATCCAAGAGCTTTGAAC	0.458													11	64					0	0	0.000978159	0	0
C1orf55	163859	broad.mit.edu	37	1	226180687	226180687	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:226180687G>A	uc001hpu.3	-	3	308	c.255C>T	c.(253-255)CTC>CTT	p.L85L	C1orf55_uc001hpv.2_Silent_p.L85L	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	85										lung(1)	1	Breast(184;0.197)					CAAGTGCTCGGAGCATAGATC	0.423													11	50					0	0	0.00136819	0	0
OBSCN	84033	broad.mit.edu	37	1	228559341	228559341	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:228559341C>T	uc009xez.1	+	94	20906	c.20862C>T	c.(20860-20862)ACC>ACT	p.T6954T	OBSCN_uc001hsr.1_Silent_p.T1583T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6954					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCTCTGGCACCCACTTGGCCC	0.701													7	10					0	0	0.000157383	0	0
SCCPDH	51097	broad.mit.edu	37	1	246887838	246887838	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:246887838C>T	uc001ibr.2	+	1	461	c.114C>T	c.(112-114)TCC>TCT	p.S38S		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	38				SSRLPWA -> TQPALG (in Ref. 1; AAD34044).		midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		AGCGGAGCTCCCGCCTGCCCT	0.647													8	11					0	0	0.000274275	0	0
AHCTF1	25909	broad.mit.edu	37	1	247065863	247065863	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:247065863G>A	uc001ibu.1	-	7	1088	c.1081C>T	c.(1081-1083)CGA>TGA	p.R361*	AHCTF1_uc001ibv.1_Nonsense_Mutation_p.R370*	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	361	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCATGAGATCGAAATTTCTCT	0.418													47	135					0	0	0.000781405	0	0
OR11L1	391189	broad.mit.edu	37	1	248004361	248004361	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:248004361C>G	uc001idn.1	-	1	838	c.838G>C	c.(838-840)GTG>CTG	p.V280L		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	280	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGTGTGACCACAGTGTAGAAG	0.443													3	60					0	0	6.4e-05	0	0
OR2T33	391195	broad.mit.edu	37	1	248436220	248436220	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:248436220C>T	uc010pzi.1	-	1	897	c.897G>A	c.(895-897)CTG>CTA	p.L299L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCACCGTTTCAGGGCTCCCT	0.448													66	153					0	0	0.000781405	0	0
OR2M7	391196	broad.mit.edu	37	1	248487313	248487313	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:248487313G>A	uc010pzk.1	-	1	558	c.558C>T	c.(556-558)ATC>ATT	p.I186I		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCATGAGAGGATTAGTAGGG	0.423													39	205					0	0	0.00128727	0	0
OR2T10	127069	broad.mit.edu	37	1	248756644	248756644	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr1:248756644G>A	uc010pzn.1	-	1	426	c.426C>T	c.(424-426)CTC>CTT	p.L142L		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGCCAGGAGGAGACATACCC	0.562													31	62					0	0	0.000339439	0	0
DIP2C	22982	broad.mit.edu	37	10	409149	409149	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:409149G>A	uc001ifp.2	-	21	2670	c.2580C>T	c.(2578-2580)AGC>AGT	p.S860S	DIP2C_uc009xhi.1_Silent_p.S246S|DIP2C_uc010pzz.1_Silent_p.S181S	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	860						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCAGCACACGGCTCATCCACT	0.587													4	9					0	0	0.000602214	0	0
PRKCQ	5588	broad.mit.edu	37	10	6528045	6528045	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:6528045G>A	uc001ijj.1	-	9	927	c.852C>T	c.(850-852)AAC>AAT	p.N284N	PRKCQ_uc009xim.1_Silent_p.N284N|PRKCQ_uc001iji.1_Silent_p.N317N|PRKCQ_uc009xin.1_Silent_p.N248N|PRKCQ_uc010qax.1_Silent_p.N159N	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	284					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TTAGCTTCTGGTTTATGCCAC	0.527													10	40					0	0	0.000673444	0	0
USP6NL	9712	broad.mit.edu	37	10	11505704	11505704	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:11505704G>A	uc001ikt.3	-	15	1544	c.1223C>T	c.(1222-1224)CCC>CTC	p.P408L	USP6NL_uc001iks.1_Missense_Mutation_p.P425L	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	408						intracellular	Rab GTPase activator activity				0						CCTCCTGTGGGGCGCCCCGCT	0.687													6	22					0	0	0.00116845	0	0
CAMK1D	57118	broad.mit.edu	37	10	12803030	12803030	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:12803030T>A	uc001ilo.2	+	4	618	c.383T>A	c.(382-384)GTC>GAC	p.V128D	CAMK1D_uc001iln.2_Missense_Mutation_p.V128D	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	128	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		ATCCGCCAAGTCTTGGACGCC	0.552													6	147					0	0	0.00116845	0	0
ARMC3	219681	broad.mit.edu	37	10	23250819	23250819	+	Nonsense_Mutation	SNP	C	T	T	rs78062147		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:23250819C>T	uc001irm.3	+	7	627	c.544C>T	c.(544-546)CAG>TAG	p.Q182*	ARMC3_uc010qcv.1_Nonsense_Mutation_p.Q182*|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	182	ARM 5.						binding				0						GCAGGATTTTCAGTGTCGAGC	0.333													10	22					0	0	0.00136819	0	0
GPR158	57512	broad.mit.edu	37	10	25684866	25684866	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:25684866C>T	uc001isj.2	+	3	1095	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	345	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCCTAGGATTCGTTCTTGGAG	0.413													9	22					0	0	0.000442599	0	0
MYO3A	53904	broad.mit.edu	37	10	26241128	26241128	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:26241128G>A	uc001isn.2	+	3	449	c.89G>A	c.(88-90)GGA>GAA	p.G30E	MYO3A_uc009xko.1_Missense_Mutation_p.G30E|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.G30E|MYO3A_uc001ism.2_Missense_Mutation_p.G30E	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	30	Protein kinase.|ATP (By similarity).				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						ATTGGCAAAGGAACTTATGGG	0.323													18	34					0	0	0.00074312	0	0
YME1L1	10730	broad.mit.edu	37	10	27423048	27423048	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:27423048G>A	uc001iti.2	-	8	1048	c.866C>T	c.(865-867)TCC>TTC	p.S289F	YME1L1_uc001itj.2_Missense_Mutation_p.S232F|YME1L1_uc010qdl.1_Missense_Mutation_p.S199F|YME1L1_uc009xkv.2_RNA	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	289					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCGCCTTAGGGAATCTAGGAG	0.318													8	17					0	0	0.000157383	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318722	30318722	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:30318722C>T	uc001iux.2	-	2	414	c.355G>A	c.(355-357)GGA>AGA	p.G119R	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Missense_Mutation_p.G119R	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	119										ovary(4)	4						TCTTGCCGTCCTCTTCTCCGG	0.577													13	41					0	0	0.00136819	0	0
ZEB1	6935	broad.mit.edu	37	10	31810034	31810034	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:31810034A>T	uc001ivs.3	+	7	1834	c.1771A>T	c.(1771-1773)AAC>TAC	p.N591Y	ZEB1_uc001ivr.3_Missense_Mutation_p.N373Y|ZEB1_uc010qee.1_Missense_Mutation_p.N373Y|ZEB1_uc010qef.1_Missense_Mutation_p.N373Y|ZEB1_uc009xlj.1_Missense_Mutation_p.N517Y|ZEB1_uc010qeg.1_Missense_Mutation_p.N450Y|ZEB1_uc009xlk.1_Missense_Mutation_p.N373Y|ZEB1_uc001ivt.3_Missense_Mutation_p.N373Y|ZEB1_uc001ivu.3_Missense_Mutation_p.N592Y|ZEB1_uc001ivv.3_Missense_Mutation_p.N571Y|ZEB1_uc010qeh.1_Missense_Mutation_p.N524Y|ZEB1_uc009xlo.1_Missense_Mutation_p.N574Y|ZEB1_uc009xlp.2_Missense_Mutation_p.N575Y	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	591	Homeobox; atypical.				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				ACCTTTAAAGAACCTCTTGTC	0.458													8	41					0	0	0.000274275	0	0
ASAH2	56624	broad.mit.edu	37	10	52002964	52002964	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:52002964C>T	uc001jjd.2	-	3	508	c.508G>A	c.(508-510)GAG>AAG	p.E170K	ASAH2_uc009xos.2_Missense_Mutation_p.E170K	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	170	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						TCACTTACCTCCAGCCTGAGC	0.428													21	73					0	0	0.000229342	0	0
PRKG1	5592	broad.mit.edu	37	10	54041970	54041970	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:54041970G>A	uc001jjm.2	+	14	1752	c.1558G>A	c.(1558-1560)GGG>AGG	p.G520R	PRKG1_uc001jjo.2_Missense_Mutation_p.G535R|PRKG1_uc009xow.1_Missense_Mutation_p.G238R|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	520	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		GACTTTTTGTGGGACTCCAGA	0.403													19	37					0	0	0.000958276	0	0
MBL2	4153	broad.mit.edu	37	10	54528199	54528199	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:54528199C>T	uc001jjt.2	-	4	510	c.445G>A	c.(445-447)GAA>AAA	p.E149K		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	149	C-type lectin.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						TTCACTTTTTCAAAGGTCATT	0.473													28	79					0	0	0.00106085	0	0
PCDH15	65217	broad.mit.edu	37	10	55582729	55582729	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:55582729C>T	uc001jju.1	-	33	5152	c.4757G>A	c.(4756-4758)AGG>AAG	p.R1586K	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.R1583K|PCDH15_uc010qhw.1_Missense_Mutation_p.R1546K|PCDH15_uc010qhx.1_Missense_Mutation_p.R1517K|PCDH15_uc010qhy.1_Missense_Mutation_p.R1593K|PCDH15_uc010qhz.1_Missense_Mutation_p.R1588K|PCDH15_uc010qia.1_Missense_Mutation_p.R1566K|PCDH15_uc010qib.1_Missense_Mutation_p.R1563K	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1586	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGGAACTTTCCTCATCAGCCT	0.463										HNSCC(58;0.16)			18	46					0	0	0.000295444	0	0
ARID5B	84159	broad.mit.edu	37	10	63851334	63851334	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:63851334C>T	uc001jlt.1	+	10	2138	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	704					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					GGGCCAGCCTCTCCAGCAGCT	0.532													17	29					0	0	0.00074312	0	0
CDH23	64072	broad.mit.edu	37	10	73376977	73376977	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:73376977G>A	uc001jrx.3	+	11	1338	c.961G>A	c.(961-963)GAT>AAT	p.D321N	CDH23_uc001jrw.3_Missense_Mutation_p.D321N|CDH23_uc009xql.2_Missense_Mutation_p.D366N	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	321	Cadherin 3.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGAGCTGAACGATGACCGCAC	0.443													5	16					0	0	0.000602214	0	0
CAMK2G	818	broad.mit.edu	37	10	75608802	75608802	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:75608802G>A	uc001jvv.1	-	7	586	c.462C>T	c.(460-462)ATC>ATT	p.I154I	CAMK2G_uc001jvm.1_Silent_p.I162I|CAMK2G_uc001jvo.1_Silent_p.I162I|CAMK2G_uc001jvq.1_Silent_p.I162I|CAMK2G_uc001jvr.1_Silent_p.I162I|CAMK2G_uc001jvp.1_Silent_p.I162I|CAMK2G_uc001jvs.1_Silent_p.I162I|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Silent_p.I140I|CAMK2G_uc010qkv.1_Intron	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II	162	Protein kinase.				insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CCTGTACTTCGATGGCTAGGC	0.562											OREG0020267	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	33					0	0	0.000958276	0	0
SFTPD	6441	broad.mit.edu	37	10	81697824	81697824	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:81697824G>A	uc001kbh.2	-	8	955	c.912C>T	c.(910-912)GTC>GTT	p.V304V	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	304	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCTTAGCTACGACCAGCTGTT	0.557													27	66					0	0	0.000878237	0	0
BTAF1	9044	broad.mit.edu	37	10	93740304	93740304	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:93740304C>T	uc001khr.2	+	15	1842	c.1744C>T	c.(1744-1746)CTT>TTT	p.L582F	BTAF1_uc001khs.1_Missense_Mutation_p.L252F|BTAF1_uc001kht.1_Missense_Mutation_p.L20F	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	582	HEAT 4.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AATTCTGGACCTTATTCACAA	0.353													16	38					0	0	0.000566183	0	0
MYOF	26509	broad.mit.edu	37	10	95097616	95097616	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:95097616C>T	uc001kin.2	-	40	4516	c.4393G>A	c.(4393-4395)GAA>AAA	p.E1465K	MYOF_uc001kio.2_Missense_Mutation_p.E1452K|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1465	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CCGCATTTTTCATGTTCCCCT	0.423													17	53					0	0	0.00152264	0	0
POLL	27343	broad.mit.edu	37	10	103339317	103339317	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:103339317G>A	uc001ktg.1	-	8	2387	c.1621C>T	c.(1621-1623)CAT>TAT	p.H541Y	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Missense_Mutation_p.H214Y|POLL_uc001kte.1_Missense_Mutation_p.H233Y|POLL_uc001kth.1_Missense_Mutation_p.H266Y|POLL_uc001kti.1_Missense_Mutation_p.H541Y|POLL_uc001ktj.1_Missense_Mutation_p.H541Y|POLL_uc001ktf.2_Missense_Mutation_p.H449Y|POLL_uc001ktk.1_Missense_Mutation_p.H280Y|POLL_uc010qqa.1_Missense_Mutation_p.H280Y|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Missense_Mutation_p.H541Y|POLL_uc001ktl.2_Missense_Mutation_p.H453Y|POLL_uc010qqc.1_Missense_Mutation_p.H233Y	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	541					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		TTGCAGCCATGGGTGTTCCGG	0.617								DNA_polymerases_(catalytic_subunits)					16	28					0	0	0.00074312	0	0
PCGF6	84108	broad.mit.edu	37	10	105104827	105104827	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:105104827G>A	uc001kwt.2	-	6	804	c.736C>T	c.(736-738)CGT>TGT	p.R246C	PCGF6_uc001kwu.2_Intron|PCGF6_uc009xxk.2_RNA|PCGF6_uc009xxl.2_RNA|PCGF6_uc009xxm.2_RNA	NM_001011663	NP_001011663	Q9BYE7	PCGF6_HUMAN	polycomb group ring finger 6 isoform a	246					negative regulation of transcription, DNA-dependent	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)	1		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;2.57e-09)|all cancers(201;7.21e-08)|BRCA - Breast invasive adenocarcinoma(275;0.205)		GGTGGAATACGAAACACTGAT	0.318													13	54					0	0	0.000422831	0	0
ACSL5	51703	broad.mit.edu	37	10	114177625	114177625	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:114177625C>T	uc001kzs.2	+	14	1381	c.1240C>T	c.(1240-1242)CGT>TGT	p.R414C	ACSL5_uc001kzt.2_Missense_Mutation_p.R414C|ACSL5_uc001kzu.2_Missense_Mutation_p.R470C|ACSL5_uc009xxz.2_Missense_Mutation_p.R414C|ACSL5_uc010qrj.1_Missense_Mutation_p.R196C	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	414	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		CGGAAGGGTTCGTGTAATTGT	0.383													23	78					0	0	0.000720815	0	0
C10orf96	374355	broad.mit.edu	37	10	118101596	118101596	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:118101596G>A	uc001lck.2	+	5	582	c.331G>A	c.(331-333)GAA>AAA	p.E111K		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	111										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		ATTTATTAAGGAAATTACAGA	0.264													10	57					0	0	0.00136819	0	0
PNLIP	5406	broad.mit.edu	37	10	118306870	118306870	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:118306870G>A	uc001lcm.2	+	3	154	c.111G>A	c.(109-111)ACG>ACA	p.T37T		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	37					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CAGGAATTACGGAAAGACCCC	0.428													14	44					0	0	0.000422831	0	0
SFXN4	119559	broad.mit.edu	37	10	120917223	120917223	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:120917223G>A	uc001leb.2	-	9	539	c.494C>T	c.(493-495)TCA>TTA	p.S165L	SFXN4_uc001ldy.2_Missense_Mutation_p.S49L|SFXN4_uc001ldz.2_Missense_Mutation_p.S49L|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	165	Helical; (Potential).				iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		CATTAGTAATGATCTTTCTAG	0.333													8	33					0	0	0.000308642	0	0
TACC2	10579	broad.mit.edu	37	10	123845037	123845037	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:123845037G>A	uc001lfv.2	+	4	3382	c.3022G>A	c.(3022-3024)GAA>AAA	p.E1008K	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.E1008K|TACC2_uc010qtv.1_Missense_Mutation_p.E1008K	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1008						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CAGCCAGCATGAAGAAGCATG	0.532													9	21					0	0	0.000274275	0	0
DMBT1	1755	broad.mit.edu	37	10	124399588	124399588	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:124399588C>T	uc001lgk.1	+	52	6694	c.6588C>T	c.(6586-6588)TTC>TTT	p.F2196F	DMBT1_uc001lgl.1_Silent_p.F2186F|DMBT1_uc001lgm.1_Silent_p.F1568F|DMBT1_uc009xzz.1_Silent_p.F2195F|DMBT1_uc010qtx.1_Silent_p.F916F|DMBT1_uc009yab.1_Silent_p.F899F|DMBT1_uc009yac.1_Silent_p.F490F	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2196	ZP.			F -> L (in Ref. 2; CAB56155).	epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATTCCAACTTCCTCACAGCAG	0.522													10	35					0	0	0.000978159	0	0
MGMT	4255	broad.mit.edu	37	10	131506261	131506261	+	Silent	SNP	C	T	T	rs112373357		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr10:131506261C>T	uc001lkh.2	+	3	347	c.321C>T	c.(319-321)ATC>ATT	p.I107I		NM_002412	NP_002403	P16455	MGMT_HUMAN	O-6-methylguanine-DNA methyltransferase	76								p.I76I(1)		ovary(1)|breast(1)	2		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		CCGAGGCTATCGAAGAGTTCC	0.597								Direct_reversal_of_damage					19	53					0	0	0.00121646	0	0
LRRC56	115399	broad.mit.edu	37	11	540700	540700	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:540700G>A	uc010qvz.1	+	4	521	c.16G>A	c.(16-18)GAC>AAC	p.D6N		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	6										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCTGGGCTGGGACAGATCCCG	0.667													12	30					0	0	0.000151284	0	0
LRRC56	115399	broad.mit.edu	37	11	541584	541584	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:541584G>C	uc010qvz.1	+	5	730	c.225G>C	c.(223-225)GAG>GAC	p.E75D		NM_198075	NP_932341	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	75										skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGACGCTGGAGATGTGTGTGG	0.637													8	28					0	0	0.000442599	0	0
MUC5B	727897	broad.mit.edu	37	11	1269208	1269208	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:1269208G>A	uc009ycr.1	+	50	12808	c.12682G>A	c.(12682-12684)GCC>ACC	p.A4228T	MUC5B_uc001ltb.2_Missense_Mutation_p.A3703T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3700	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GACCACAACAGCCACTACGAC	0.652													22	106					0	0	0.000878237	0	0
KCNQ1	3784	broad.mit.edu	37	11	2608915	2608915	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:2608915C>T	uc001lwn.2	+	9	1352	c.1244C>T	c.(1243-1245)TCT>TTT	p.S415F	KCNQ1_uc009ydp.1_Missense_Mutation_p.S199F|KCNQ1_uc001lwo.2_Missense_Mutation_p.S288F	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	415	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CCCAAGAAGTCTGTGGTGGTG	0.647													33	165					0	0	0.000491102	0	0
OR52N4	390072	broad.mit.edu	37	11	5776758	5776758	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:5776758C>T	uc001mbu.2	+	1	836	c.788C>T	c.(787-789)TCC>TTC	p.S263F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TCCTTCTTTTCCCACCGCTTT	0.478													32	88					0	0	0.000692331	0	0
NLRP10	338322	broad.mit.edu	37	11	7984855	7984855	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:7984855G>A	uc001mfv.1	-	1	205	c.188C>T	c.(187-189)TCA>TTA	p.S63L		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	63	DAPIN.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCATACTTTGAAATCAGTAA	0.517													16	51					0	0	0.00121646	0	0
LYVE1	10894	broad.mit.edu	37	11	10585851	10585851	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:10585851C>T	uc001miv.2	-	2	442	c.156G>A	c.(154-156)CTG>CTA	p.L52L	uc001miu.2_Intron|LYVE1_uc010rca.1_Intron	NM_006691	NP_006682	Q9Y5Y7	LYVE1_HUMAN	lymphatic vessel endothelial hyaluronan receptor	52	Link.|Extracellular (Potential).				anatomical structure morphogenesis|cell-matrix adhesion|cellular component movement|response to wounding|transport	integral to plasma membrane|membrane fraction				central_nervous_system(1)|skin(1)	2				all cancers(16;7.22e-08)|Epithelial(150;1.03e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0609)		CTGTGAAATTCAGCTGCTGGT	0.483													15	37					0	0	0.000219431	0	0
ABCC8	6833	broad.mit.edu	37	11	17452441	17452441	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:17452441G>A	uc001mnc.2	-	12	1863	c.1737C>T	c.(1735-1737)TCC>TCT	p.S579S	ABCC8_uc010rcy.1_Silent_p.S578S	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	579	Extracellular (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGAGGGAGAGGGAGGCAAAGG	0.607													91	350					0	0	0.000781405	0	0
IGSF22	283284	broad.mit.edu	37	11	18741335	18741335	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:18741335C>T	uc009yht.2	-	7	814	c.624G>A	c.(622-624)ATG>ATA	p.M208I	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	208	Lys-rich.									ovary(4)|large_intestine(2)|kidney(1)	7						AACCATACTCCATGCACACCT	0.507													71	94					0	0	0.000781405	0	0
E2F8	79733	broad.mit.edu	37	11	19247144	19247144	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:19247144G>A	uc001mpm.2	-	12	2567	c.2045C>T	c.(2044-2046)TCA>TTA	p.S682L	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.S682L	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	682					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GAGTTCAGATGATGTCACTGG	0.453													28	39					0	0	0.000409698	0	0
NELL1	4745	broad.mit.edu	37	11	20869158	20869158	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:20869158G>T	uc001mqe.2	+	4	518	c.365G>T	c.(364-366)AGG>ATG	p.R122M	NELL1_uc001mqf.2_Missense_Mutation_p.R122M|NELL1_uc009yid.2_Missense_Mutation_p.R150M|NELL1_uc010rdo.1_Intron|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	122	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						AGTGGCCTGAGGGATGAGATT	0.448													6	21					0.000442599	0.00245743	0.000442599	1	0
ELP4	26610	broad.mit.edu	37	11	31531334	31531334	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:31531334G>A	uc001mtb.2	+	1	38	c.3G>A	c.(1-3)ATG>ATA	p.M1I	IMMP1L_uc001msy.1_5'Flank|IMMP1L_uc001msz.1_5'Flank|ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.M1I|ELP4_uc010rdz.1_Missense_Mutation_p.M1I|IMMP1L_uc009yjo.2_5'Flank|IMMP1L_uc009yjp.2_5'Flank	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	1					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					GCTCTAAGATGGCGGCAGTGG	0.592													6	33					0	0	0.00116845	0	0
HSD17B12	51144	broad.mit.edu	37	11	43819886	43819886	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:43819886G>A	uc001mxq.3	+	4	535	c.300G>A	c.(298-300)GTG>GTA	p.V100V		NM_016142	NP_057226	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	100					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity				0						AATTCAAAGTGGAGACAAGAA	0.363													33	37					0	0	0.000339439	0	0
LRP4	4038	broad.mit.edu	37	11	46900852	46900852	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:46900852G>A	uc001ndn.3	-	21	2975	c.2829C>T	c.(2827-2829)AGC>AGT	p.S943S		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	943	Extracellular (Potential).|LDL-receptor class B 9.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GGGGGAGCTGGCTTCCAATCA	0.443													16	25					0	0	0.000958276	0	0
OR4B1	119765	broad.mit.edu	37	11	48239105	48239105	+	Silent	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:48239105T>C	uc010rhs.1	+	1	744	c.744T>C	c.(742-744)TTT>TTC	p.F248F		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TCATCTTGTTTTTTGGACCTG	0.473													15	51					0	0	0.000422831	0	0
OR5M10	390167	broad.mit.edu	37	11	56344979	56344979	+	Silent	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:56344979A>G	uc001niz.1	-	1	219	c.219T>C	c.(217-219)TAT>TAC	p.Y73Y		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATTGGAAGAATAGCAAATGT	0.463													19	62					0	0	0.00121646	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947403	57947403	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:57947403G>A	uc001nmj.2	+	3	803	c.487G>A	c.(487-489)GCC>ACC	p.A163T		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				GACAGTCTCAGCCTTCACTCT	0.522													17	21					0	0	0.000422831	0	0
GLYAT	10249	broad.mit.edu	37	11	58477266	58477266	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:58477266C>T	uc001nnb.2	-	6	1019	c.864G>A	c.(862-864)TGG>TGA	p.W288*		NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	288					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TCCACTGGTTCCAGCTTCTGG	0.448													25	82					0	0	0.000339439	0	0
GLYATL1	92292	broad.mit.edu	37	11	58714580	58714580	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:58714580C>T	uc001nnf.2	+	4	396	c.20C>T	c.(19-21)TCC>TTC	p.S7F	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Intron|GLYATL1_uc001nni.1_Missense_Mutation_p.S7F|GLYATL1_uc001nnj.1_Missense_Mutation_p.S7F			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	7						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	CTGAATAACTCCCATAAGCTG	0.473													12	43					0	0	0.000151284	0	0
TUT1	64852	broad.mit.edu	37	11	62343079	62343079	+	Silent	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:62343079G>T	uc001nto.2	-	9	2264	c.2226C>A	c.(2224-2226)GCC>GCA	p.A742A	EEF1G_uc001ntm.1_5'Flank|EEF1G_uc010rlw.1_5'Flank|EEF1G_uc001ntn.1_5'Flank|TUT1_uc001ntp.1_Silent_p.A238A	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	704					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						GGCTCTGCATGGCCCAGTCCT	0.637													9	213					0.000442599	0.00245743	0.000442599	1	0
SLC22A6	9356	broad.mit.edu	37	11	62744811	62744811	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:62744811G>A	uc001nwk.2	-	9	1717	c.1410C>T	c.(1408-1410)ATC>ATT	p.I470I	SLC22A6_uc001nwl.2_Intron|SLC22A6_uc001nwj.2_Silent_p.I470I|SLC22A6_uc001nwm.2_Intron	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	470	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						GTGGGCTCACGATGCTGCCCA	0.622													6	25					0	0	8.12818e-05	0	0
SLC22A9	114571	broad.mit.edu	37	11	63143144	63143144	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:63143144C>T	uc001nww.2	+	5	1126	c.858C>T	c.(856-858)CTC>CTT	p.L286L	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	286	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						CTCGGTGGCTCATTATCAACA	0.448													9	49					0	0	0.000274275	0	0
GPR137	56834	broad.mit.edu	37	11	64056683	64056683	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:64056683C>T	uc001nzg.1	+	8	1408	c.1100C>T	c.(1099-1101)CCC>CTC	p.P367L	GPR137_uc010rni.1_Missense_Mutation_p.P425L|GPR137_uc001nzf.2_3'UTR|GPR137_uc001nzi.2_3'UTR|GPR137_uc010rnj.1_3'UTR|KCNK4_uc009ypl.1_5'Flank|KCNK4_uc001nzj.1_5'Flank|KCNK4_uc001nzk.1_5'Flank|KCNK4_uc010rnk.1_5'Flank|KCNK4_uc001nzl.1_5'Flank|KCNK4_uc001nzm.3_5'Flank|KCNK4_uc001nzn.1_5'Flank	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	367	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1						CCTCCCTCCCCCACAGAATAC	0.647													10	38					0	0	0.000442599	0	0
RIN1	9610	broad.mit.edu	37	11	66103267	66103267	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:66103267G>A	uc001ohn.1	-	3	475	c.348C>T	c.(346-348)TTC>TTT	p.F116F	RIN1_uc010roy.1_5'Flank|RIN1_uc009yrd.1_5'UTR|RIN1_uc010roz.1_Silent_p.F11F|RIN1_uc010rpa.1_Silent_p.F11F	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	116	SH2.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						GGCTGGAGACGAAGGAGGGGC	0.637													11	13					0	0	0.000978159	0	0
B3GNT1	11041	broad.mit.edu	37	11	66113990	66113990	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:66113990G>A	uc001ohr.2	-	1	1172	c.1027C>T	c.(1027-1029)CGG>TGG	p.R343W	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	343	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						CCGTACTGCCGAAAGCGCTCG	0.622													23	33					0	0	0.000878237	0	0
CABP4	57010	broad.mit.edu	37	11	67223192	67223192	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:67223192C>T	uc001olo.2	+	1	375	c.298C>T	c.(298-300)CGT>TGT	p.R100C	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_5'UTR	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	100					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CCACCGACATCGTCCTGACTC	0.677													8	12					0	0	0.000274275	0	0
SHANK2	22941	broad.mit.edu	37	11	70331907	70331907	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:70331907C>T	uc001oqc.2	-	21	4569	c.4491G>A	c.(4489-4491)CGG>CGA	p.R1497R	SHANK2_uc010rqn.1_Silent_p.R909R|SHANK2_uc001opz.2_Silent_p.R902R|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1118					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CGCTGCTACTCCGGCTGTCCA	0.592													28	28					0	0	0.00106085	0	0
PDE2A	5138	broad.mit.edu	37	11	72292005	72292005	+	Silent	SNP	G	A	A	rs146299609	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:72292005G>A	uc010rrc.1	-	24	2301	c.2058C>T	c.(2056-2058)ATC>ATT	p.I686I	PDE2A_uc001oso.2_Silent_p.I665I|PDE2A_uc010rra.1_Silent_p.I679I|PDE2A_uc001osn.2_Silent_p.I430I|PDE2A_uc010rrb.1_Silent_p.I677I|PDE2A_uc010rrd.1_Silent_p.I571I	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	686	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	ACAAGGCAAAGATCTCGATGT	0.512													36	143					0	0	0.00148497	0	0
UCP3	7352	broad.mit.edu	37	11	73715038	73715038	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:73715038G>C	uc001our.2	-	6	1013	c.658C>G	c.(658-660)CAC>GAC	p.H220D	UCP3_uc001ous.2_Missense_Mutation_p.H220D	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	220	Helical; Name=5; (Potential).|Solcar 3.				mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					GAGACAAAGTGGCAGGGGAAG	0.532													6	20					0	0	0.00116845	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74880348	74880348	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:74880348C>T	uc001owb.2	+	5	966	c.579C>T	c.(577-579)TTC>TTT	p.F193F	SLCO2B1_uc010rrq.1_Intron|SLCO2B1_uc010rrr.1_Silent_p.F49F|SLCO2B1_uc010rrs.1_Silent_p.F77F|SLCO2B1_uc001owc.2_Intron|SLCO2B1_uc001owd.2_Silent_p.F171F	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	193	Helical; Name=4; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	GGATCATGTTCGTGGCACAGA	0.612													30	31					0	0	0.000339439	0	0
MOGAT2	80168	broad.mit.edu	37	11	75439858	75439858	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:75439858C>T	uc010rru.1	+	5	674	c.674C>T	c.(673-675)TCC>TTC	p.S225F	MOGAT2_uc001oww.1_3'UTR|MOGAT2_uc010rrv.1_Missense_Mutation_p.S143F	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	225					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)					CCAATCTTCTCCTTCGGGGAG	0.537													20	58					0	0	0.000295444	0	0
CAPN5	726	broad.mit.edu	37	11	76804825	76804825	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:76804825C>T	uc001oxx.2	+	3	448	c.263C>T	c.(262-264)TCG>TTG	p.S88L	CAPN5_uc009yup.2_Missense_Mutation_p.S128L|CAPN5_uc009yuq.2_Missense_Mutation_p.S124L|CAPN5_uc001oxy.2_Missense_Mutation_p.S128L	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	88	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GCAGCCTGCTCGTCACTTGCC	0.662													12	9					0	0	0.00136819	0	0
RAB30	27314	broad.mit.edu	37	11	82693213	82693213	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:82693213G>A	uc001ozu.2	-	6	867	c.606C>T	c.(604-606)TTC>TTT	p.F202F	RAB30_uc009yve.2_Silent_p.F200F|RAB30_uc010rst.1_Silent_p.F200F|RAB30_uc001ozv.2_3'UTR	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	202					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						GCCTTTAGTTGAAATTACAAC	0.493													17	61					0	0	0.000958276	0	0
GRM5	2915	broad.mit.edu	37	11	88337902	88337902	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:88337902C>T	uc001pcq.2	-	4	1578	c.1378G>A	c.(1378-1380)GGA>AGA	p.G460R	GRM5_uc009yvm.2_Missense_Mutation_p.G460R	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	460	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GGAGAGTCTCCATTCTCATCG	0.428													7	18					0	0	8.12818e-05	0	0
FAT3	120114	broad.mit.edu	37	11	92573801	92573801	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:92573801C>T	uc001pdj.3	+	17	10459	c.10442C>T	c.(10441-10443)CCC>CTC	p.P3481L	FAT3_uc001pdi.3_5'UTR	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3481	Cadherin 32.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATGGGCCTCCCTTTTCATTC	0.473										TCGA Ovarian(4;0.039)			112	416					0	0	0.000781405	0	0
PIWIL4	143689	broad.mit.edu	37	11	94318641	94318641	+	Silent	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:94318641T>C	uc001pfa.2	+	6	877	c.666T>C	c.(664-666)ATT>ATC	p.I222I	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	222					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGTACCAAATTGGACGGAACT	0.333													30	120					0	0	0.00058488	0	0
ENDOD1	23052	broad.mit.edu	37	11	94862342	94862342	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:94862342G>A	uc001pfh.2	+	2	1177	c.1102G>A	c.(1102-1104)GTG>ATG	p.V368M		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	368						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				TACCAAGCAGGTGATTAATGG	0.443													10	67					0	0	0.000673444	0	0
C11orf70	85016	broad.mit.edu	37	11	101946721	101946721	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:101946721G>A	uc001pgp.2	+	5	581	c.553G>A	c.(553-555)GAT>AAT	p.D185N	C11orf70_uc001pgo.2_3'UTR|C11orf70_uc001pgq.2_Missense_Mutation_p.D147N	NM_032930	NP_116319	Q9BRQ4	CK070_HUMAN	hypothetical protein LOC85016	185										skin(1)	1	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		TCAATATGAGGATGTGATTAG	0.358													34	54					0	0	0.000692331	0	0
CASP5	838	broad.mit.edu	37	11	104866478	104866478	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:104866478C>T	uc010rva.1	-	9	1330	c.1298G>A	c.(1297-1299)GGC>GAC	p.G433D	CASP5_uc010ruz.1_Missense_Mutation_p.G446D|CASP5_uc010rvb.1_Missense_Mutation_p.G375D|CASP5_uc010rvc.1_Missense_Mutation_p.G291D|CASP5_uc009yxh.2_Missense_Mutation_p.G215D|CASP5_uc010rvd.1_Missense_Mutation_p.G215D	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	433					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TTTTCAATTGCCAGGAAAGAG	0.403													25	41					0	0	0.00047179	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558471	106558471	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:106558471C>T	uc001pjg.1	-	8	2393	c.2003G>A	c.(2002-2004)CGA>CAA	p.R668Q	GUCY1A2_uc010rvo.1_Missense_Mutation_p.R689Q|GUCY1A2_uc009yxn.1_Missense_Mutation_p.R699Q	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	668					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ACTTTCTTCTCGTTTTAATAA	0.403													43	52					0	0	0.000374591	0	0
ELMOD1	55531	broad.mit.edu	37	11	107518222	107518222	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:107518222C>T	uc010rvs.1	+	7	853	c.449C>T	c.(448-450)CCA>CTA	p.P150L	ELMOD1_uc001pjm.2_Missense_Mutation_p.P150L|ELMOD1_uc010rvt.1_Missense_Mutation_p.P144L	NM_018712	NP_061182	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1 isoform 1	150	ELMO.				phagocytosis	cytoskeleton	GTPase activator activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		CCCAATACTCCACTGGAATCT	0.383													21	31					0	0	0.000586117	0	0
MLL	4297	broad.mit.edu	37	11	118344497	118344497	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:118344497G>A	uc001pta.2	+	3	2646	c.2623G>A	c.(2623-2625)GAG>AAG	p.E875K	MLL_uc001ptb.2_Missense_Mutation_p.E875K|MLL_uc001psz.1_Missense_Mutation_p.E908K|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	875					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		caagagtagagagagagaccg	0.274			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								20	11					0	0	0.000958276	0	0
TREH	11181	broad.mit.edu	37	11	118532427	118532427	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:118532427C>T	uc001pty.1	-	6	581	c.536G>A	c.(535-537)TGG>TAG	p.W179*	TREH_uc009zaj.1_Intron|TREH_uc001ptz.1_Nonsense_Mutation_p.W56*|TREH_uc009zak.2_Nonsense_Mutation_p.W179*	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	179					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		CTCCATGACCCAGTAGGAGTC	0.632													5	32					0	0	0.000602214	0	0
SORL1	6653	broad.mit.edu	37	11	121474953	121474953	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:121474953G>A	uc001pxx.2	+	33	4651	c.4571G>A	c.(4570-4572)GGG>GAG	p.G1524E	SORL1_uc010rzp.1_Missense_Mutation_p.G370E|SORL1_uc010rzq.1_Missense_Mutation_p.G139E	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1524	Extracellular (Potential).|LDL-receptor class A 11.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGCGAGGACGGGGAGGCCTGC	0.597													32	95					0	0	0.00148497	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128840253	128840253	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:128840253G>A	uc009zcp.2	-	22	4813	c.4813C>T	c.(4813-4815)CCC>TCC	p.P1605S	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.P564S|ARHGAP32_uc001qez.2_Missense_Mutation_p.P1256S	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1605	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						TCATCTGGGGGAACTTCTGTC	0.532													11	47					0	0	0.00136819	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130342971	130342971	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr11:130342971C>T	uc010scd.1	+	8	2108	c.2108C>T	c.(2107-2109)CCC>CTC	p.P703L		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	703	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GTGGCCATCCCCGCAGGCGCC	0.592													15	54					0	0	0.000422831	0	0
VWF	7450	broad.mit.edu	37	12	6230478	6230478	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:6230478C>G	uc001qnn.1	-	3	332	c.82G>C	c.(82-84)GGC>CGC	p.G28R	VWF_uc010set.1_Missense_Mutation_p.G28R|VWF_uc001qno.1_Missense_Mutation_p.G65R	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	28					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	GATGACCTGCCGCGAGTTCCT	0.572													15	19					0	0	0.00074312	0	0
CHD4	1108	broad.mit.edu	37	12	6690874	6690874	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:6690874G>A	uc001qpo.2	-	31	4786	c.4622C>T	c.(4621-4623)CCT>CTT	p.P1541L	CHD4_uc001qpn.2_Missense_Mutation_p.P1534L|CHD4_uc001qpp.2_Missense_Mutation_p.P1566L|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1541					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GGAGGGTGTAGGAGTTTTTGG	0.542													65	54					0	0	0.000781405	0	0
CD163L1	283316	broad.mit.edu	37	12	7559384	7559384	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:7559384C>T	uc001qsy.2	-	5	857	c.831G>A	c.(829-831)CTG>CTA	p.L277L	CD163L1_uc010sge.1_Silent_p.L287L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	277	SRCR 3.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CTTGGATTTTCAGCTCTACTC	0.478													49	116					0	0	0.000781405	0	0
SLC2A14	144195	broad.mit.edu	37	12	7970528	7970528	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:7970528C>T	uc001qtk.2	-	15	2036	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K	SLC2A14_uc001qtl.2_Missense_Mutation_p.E392K|SLC2A14_uc001qtm.2_Missense_Mutation_p.E392K|SLC2A14_uc010sgg.1_Missense_Mutation_p.E306K|SLC2A14_uc001qtn.2_Missense_Mutation_p.E415K|SLC2A14_uc001qto.2_Missense_Mutation_p.E50K|SLC2A14_uc010sgh.1_Missense_Mutation_p.E430K	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	415	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		CTGAAGAGTTCGGCCACAATA	0.557													16	51					0	0	0.00074312	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906490	13906490	+	Silent	SNP	G	A	A	rs142203984		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:13906490G>A	uc001rbt.2	-	3	950	c.771C>T	c.(769-771)ATC>ATT	p.I257I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	257	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.I257I(1)		central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACTGGGCACGATCCACGTGT	0.532													40	41					0	0	0.000589545	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21229492	21229492	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:21229492C>T	uc010sil.1	+	15	2102	c.2037C>T	c.(2035-2037)TCC>TCT	p.S679S	LST-3TM12_uc010sim.1_Silent_p.S618S|LST-3TM12_uc010sin.1_Silent_p.S571S			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TATATAATTCCACATATTTGG	0.318													128	114					0	0	0.000781405	0	0
FGD4	121512	broad.mit.edu	37	12	32755164	32755164	+	Nonsense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:32755164T>A	uc001rkz.2	+	7	1383	c.906T>A	c.(904-906)TAT>TAA	p.Y302*	FGD4_uc001rlc.2_Nonsense_Mutation_p.Y387*|FGD4_uc001rky.2_Nonsense_Mutation_p.Y54*|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Nonsense_Mutation_p.Y414*|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	302	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					ATGGAGAATATGTGAAAGGAT	0.348													29	212					0	0	0.000339439	0	0
LRRK2	120892	broad.mit.edu	37	12	40704392	40704392	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:40704392G>A	uc001rmg.3	+	31	4598	c.4477G>A	c.(4477-4479)GAA>AAA	p.E1493K	LRRK2_uc009zjw.2_Missense_Mutation_p.E331K|LRRK2_uc001rmi.2_Missense_Mutation_p.E326K	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1493	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGCCACCGAGGAATCTGATGC	0.428													72	222					0	0	0.000781405	0	0
DNAJC22	79962	broad.mit.edu	37	12	49742682	49742682	+	Silent	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:49742682T>C	uc001rua.2	+	2	428	c.27T>C	c.(25-27)TAT>TAC	p.Y9Y	DNAJC22_uc001rub.2_Silent_p.Y9Y	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	9	Helical; (Potential).				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						TGGTGACCTATGCCCTCTGGG	0.642													13	51					0	0	0.000422831	0	0
BCDIN3D	144233	broad.mit.edu	37	12	50232547	50232547	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:50232547G>A	uc001rvh.2	-	2	528	c.486C>T	c.(484-486)TTC>TTT	p.F162F	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	162	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						TTGACATGCAGAAGCCAATGT	0.468											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	54					0	0	0.000219431	0	0
KRT85	3891	broad.mit.edu	37	12	52760939	52760939	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:52760939G>A	uc001sag.2	-	1	371	c.251C>T	c.(250-252)TCC>TTC	p.S84F		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	84	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CACGCCCCCGGAGCGGTAGCC	0.687													24	44					0	0	0.000720815	0	0
KRT72	140807	broad.mit.edu	37	12	52994971	52994971	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:52994971G>A	uc001sar.2	-	1	352	c.266C>T	c.(265-267)CCC>CTC	p.P89L	KRT72_uc001saq.2_Missense_Mutation_p.P89L|KRT72_uc010sns.1_Missense_Mutation_p.P89L|KRT72_uc010snt.1_5'UTR	NM_001146225	NP_001139697	Q14CN4	K2C72_HUMAN	keratin 72 isoform 1	89	Head.|Gly-rich.					keratin filament	structural molecule activity			ovary(5)|pancreas(1)	6				BRCA - Breast invasive adenocarcinoma(357;0.195)		GCACACGGAGGGACACTTGGG	0.736													5	12					0	0	0.00116845	0	0
CSAD	51380	broad.mit.edu	37	12	53552462	53552463	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:53552462_53552463GG>AA	uc001sby.2	-	16	1440_1441	c.1314_1315CC>TT	c.(1312-1317)GCCCCC>GCTTCC	p.P439S	CSAD_uc001sbw.2_Missense_Mutation_p.P292S|CSAD_uc009zmt.2_Missense_Mutation_p.P221S|CSAD_uc010snx.1_Missense_Mutation_p.P466S|CSAD_uc001sbz.2_Missense_Mutation_p.P439S|CSAD_uc009zmu.2_Missense_Mutation_p.P292S|CSAD_uc001sca.3_Intron	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	439					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TTGAGCACGGGGGCCACCTGTG	0.619									Hereditary_Prostate_Cancer				4	5					0	0	6.4e-05	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54920345	54920345	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:54920345G>A	uc001sgc.3	+	21	2269	c.2190G>A	c.(2188-2190)ACG>ACA	p.T730T	NCKAP1L_uc010sox.1_Silent_p.T272T|NCKAP1L_uc010soy.1_Silent_p.T680T	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	730					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ACAATGCCACGACCCAGGAGA	0.413													32	49					0	0	0.000491102	0	0
STAT2	6773	broad.mit.edu	37	12	56748570	56748570	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:56748570T>C	uc001slc.2	-	7	703	c.625A>G	c.(625-627)AGG>GGG	p.R209G	STAT2_uc001sld.2_Missense_Mutation_p.R205G|STAT2_uc010sqn.1_Missense_Mutation_p.R205G	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	209					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						ACCTTTCTCCTTTTGTCCAGT	0.522													4	217					0	0	0.000602214	0	0
NAB2	4665	broad.mit.edu	37	12	57485769	57485769	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:57485769C>T	uc001smz.2	+	2	1323	c.945C>T	c.(943-945)CTC>CTT	p.L315L		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	315	NCD2.				cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						GCAAGCAGCTCAGCCTGCACG	0.547													10	36					0	0	0.000442599	0	0
LYZ	4069	broad.mit.edu	37	12	69746970	69746970	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:69746970C>T	uc001suw.2	+	4	473	c.418C>T	c.(418-420)CGT>TGT	p.R140C		NM_000239	NP_000230	P61626	LYSC_HUMAN	lysozyme precursor	140					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			CAGAGATGTCCGTCAGTATGT	0.378													21	84					0	0	0.000720815	0	0
KCNC2	3747	broad.mit.edu	37	12	75444313	75444313	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:75444313C>A	uc001sxg.1	-	3	2016	c.1472G>T	c.(1471-1473)AGG>ATG	p.R491M	KCNC2_uc009zry.2_Missense_Mutation_p.R491M|KCNC2_uc001sxe.2_Missense_Mutation_p.R491M|KCNC2_uc001sxf.2_Missense_Mutation_p.R491M|KCNC2_uc010stw.1_Missense_Mutation_p.R491M	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	491	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						CTTTCTTTTCCTTGGAAGTTT	0.453													14	68					1.5842e-08	8.90706e-08	0.000151284	1	0
PPFIA2	8499	broad.mit.edu	37	12	81734965	81734965	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:81734965C>T	uc001szo.1	-	20	2446	c.2285G>A	c.(2284-2286)GGT>GAT	p.G762D	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	688										ovary(3)|lung(2)|pancreas(1)	6						GTCCTCTCGACCATCTTCTTC	0.393													19	45					0	0	0.000958276	0	0
C12orf12	196477	broad.mit.edu	37	12	91347568	91347568	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:91347568C>T	uc001tbj.2	-	1	1386	c.952G>A	c.(952-954)GAG>AAG	p.E318K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	318	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						tcttcttcctcctcatcttcg	0.109													7	20					0	0	8.12818e-05	0	0
SOCS2	8835	broad.mit.edu	37	12	93968909	93968909	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:93968909C>T	uc001tcw.1	+	3	1141	c.551C>T	c.(550-552)CCA>CTA	p.P184L	SOCS2_uc001tcx.1_Missense_Mutation_p.P184L|SOCS2_uc009zsu.2_3'UTR|SOCS2_uc001tcy.1_Missense_Mutation_p.P184L|SOCS2_uc001tcz.2_3'UTR	NM_003877	NP_003868	O14508	SOCS2_HUMAN	suppressor of cytokine signaling-2	184	SOCS box.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			lung(1)	1						CTGCCTTTACCAACAAGACTA	0.408													5	32					0	0	0.000602214	0	0
C12orf63	374467	broad.mit.edu	37	12	97114192	97114192	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:97114192C>T	uc001tet.1	+	17	2167	c.2089C>T	c.(2089-2091)CTG>TTG	p.L697L		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	697	Potential.									skin(6)|ovary(1)	7						GTCGATGTTACTGATGGAAGC	0.443													9	23					0	0	0.000274275	0	0
C12orf63	374467	broad.mit.edu	37	12	97159033	97159033	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:97159033G>A	uc001tet.1	+	27	3671	c.3593G>A	c.(3592-3594)TGA>TAA	p.*1198*		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1198										skin(6)|ovary(1)	7						CAAAAAAACTGATATATGTAA	0.333													20	25					0	0	0.00152264	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640266	99640266	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:99640266C>T	uc001tge.1	-	13	2550	c.2133G>A	c.(2131-2133)GAG>GAA	p.E711E	ANKS1B_uc001tgf.1_Silent_p.E291E|ANKS1B_uc001tgk.2_Silent_p.E8E|ANKS1B_uc009ztt.1_Silent_p.E677E	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	711						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TACAGGCTCTCTCCACAAATC	0.468													12	37					0	0	0.00136819	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200442	100200442	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:100200442G>A	uc001tge.1	-	4	826	c.409C>T	c.(409-411)CAA>TAA	p.Q137*	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Nonsense_Mutation_p.Q137*	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	137	ANK 4.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TGTCCATATTGAGCTGCACAG	0.383													15	36					0	0	0.000958276	0	0
DRAM1	55332	broad.mit.edu	37	12	102302061	102302061	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:102302061C>T	uc001tix.2	+	4	903	c.440C>T	c.(439-441)TCA>TTA	p.S147L	DRAM1_uc010svv.1_Intron	NM_018370	NP_060840	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	147					apoptosis|autophagy	integral to membrane|lysosomal membrane				ovary(1)	1						TCTTACAAATCATGTCCCCAG	0.512													17	82					0	0	0.00074312	0	0
C12orf42	374470	broad.mit.edu	37	12	103762667	103762667	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:103762667G>A	uc001tjt.2	-	4	345	c.257C>T	c.(256-258)CCA>CTA	p.P86L	C12orf42_uc001tjs.2_RNA|C12orf42_uc009zuf.1_Missense_Mutation_p.P86L|C12orf42_uc001tju.2_5'UTR	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	86										ovary(1)|central_nervous_system(1)	2						TAATTTACCTGGAAAATTCAG	0.343													6	3					0	0	0.00116845	0	0
WSCD2	9671	broad.mit.edu	37	12	108589750	108589750	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:108589750G>A	uc001tms.2	+	2	885	c.141G>A	c.(139-141)GGG>GGA	p.G47G	WSCD2_uc001tmt.2_Silent_p.G47G	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	47						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						CTGTCTCGGGGAACCAGGCGA	0.612													54	68					0	0	0.000781405	0	0
CABP1	9478	broad.mit.edu	37	12	121098114	121098114	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:121098114C>T	uc001tyu.2	+	3	868	c.801C>T	c.(799-801)ATC>ATT	p.I267I	CABP1_uc001tyv.2_Silent_p.I124I|CABP1_uc001tyw.2_Silent_p.I64I|CABP1_uc001tyx.2_Silent_p.I109I	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	267	EF-hand 2.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGGAGCTCATCGAACTGTCCC	0.512													104	138					0	0	0.000781405	0	0
CHFR	55743	broad.mit.edu	37	12	133448935	133448935	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:133448935C>T	uc001ulf.2	-	4	363	c.279G>A	c.(277-279)CAG>CAA	p.Q93Q	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Silent_p.Q93Q|CHFR_uc010tbs.1_Silent_p.Q93Q|CHFR_uc001uld.2_Silent_p.Q93Q|CHFR_uc010tbt.1_Silent_p.Q93Q	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	93					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		AAGGGCATGTCTGCTTCTTAA	0.428													36	41					0	0	0.00148497	0	0
LOC100101938	100101938	broad.mit.edu	37	13	19868713	19868713	+	RNA	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:19868713C>T	uc010tck.1	-	13		c.1915G>A				NR_027248				Homo sapiens cDNA clone IMAGE:5265638.												0						AGTGCTATCTCCTTTTGTTTG	0.323													4	5					0	0	0.00024832	0	0
RXFP2	122042	broad.mit.edu	37	13	32376445	32376445	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:32376445C>T	uc001utt.2	+	18	2239	c.2168C>T	c.(2167-2169)TCT>TTT	p.S723F	RXFP2_uc010aba.2_Missense_Mutation_p.S682F	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	723	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		AAAAGTTTATCTACATCCATT	0.353													50	197					0	0	0.000781405	0	0
STARD13	90627	broad.mit.edu	37	13	33700324	33700324	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:33700324G>A	uc001uuw.2	-	7	2102	c.1976C>T	c.(1975-1977)GCT>GTT	p.A659V	STARD13_uc001uuu.2_Missense_Mutation_p.A651V|STARD13_uc001uuv.2_Missense_Mutation_p.A541V|STARD13_uc001uux.2_Missense_Mutation_p.A624V|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	659					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GCCAAAGACAGCCTTGTCTTT	0.493													70	84					0	0	0.000781405	0	0
NAA16	79612	broad.mit.edu	37	13	41932585	41932585	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:41932585C>A	uc001uyf.2	+	11	1557	c.1233C>A	c.(1231-1233)TTC>TTA	p.F411L	NAA16_uc010tfg.1_RNA|NAA16_uc001uye.3_Missense_Mutation_p.F411L|NAA16_uc001uyd.3_3'UTR	NM_024561	NP_078837	Q6N069	NAA16_HUMAN	NMDA receptor regulated 1-like protein isoform	411	TPR 6.				N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1						TAGAATTATTCTATATGAAAG	0.318													12	67					4.3838e-07	2.44929e-06	0.000151284	1	0
CAB39L	81617	broad.mit.edu	37	13	49906116	49906116	+	Silent	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:49906116G>T	uc001vcw.2	-	8	1299	c.801C>A	c.(799-801)CCC>CCA	p.P267P	CAB39L_uc001vcx.2_Silent_p.P267P|CAB39L_uc010adf.2_Silent_p.P264P	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	267					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		ACTGGATGTTGGGACTTTTAT	0.413													9	179					0.000673444	0.00371595	0.000673444	1	0
TBC1D4	9882	broad.mit.edu	37	13	75861125	75861125	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr13:75861125G>A	uc001vjl.1	-	21	4047	c.3700C>T	c.(3700-3702)CTG>TTG	p.L1234L	TBC1D4_uc010tht.1_Silent_p.L444L|TBC1D4_uc010thu.1_Silent_p.L391L|TBC1D4_uc010aer.2_Silent_p.L1226L|TBC1D4_uc010aes.2_Silent_p.L1171L	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	1234						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		AGATTTTCCAGGTTTGATTCC	0.408													20	90					0	0	0.000375601	0	0
OR4N5	390437	broad.mit.edu	37	14	20612558	20612558	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:20612558C>T	uc010tla.1	+	1	664	c.664C>T	c.(664-666)CTC>TTC	p.L222F		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGCAGTCATCCTCTGTCGTAT	0.498													23	47					0	0	0.000229342	0	0
OR11G2	390439	broad.mit.edu	37	14	20665797	20665797	+	Silent	SNP	C	T	T	rs138212036	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:20665797C>T	uc010tlb.1	+	1	303	c.303C>T	c.(301-303)CTC>CTT	p.L101L		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	101	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ACATCCTGCTCGCCAACTTCT	0.522													9	58					0	0	0.000442599	0	0
METT11D1	64745	broad.mit.edu	37	14	21463363	21463363	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:21463363C>T	uc001vyn.2	+	10	1113	c.916C>T	c.(916-918)CTC>TTC	p.L306F	METT11D1_uc001vym.2_Missense_Mutation_p.L306F|METT11D1_uc001vyo.2_Missense_Mutation_p.L306F|METT11D1_uc001vyp.2_Missense_Mutation_p.L148F|METT11D1_uc001vyq.2_Missense_Mutation_p.L148F	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	306					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		GCACAGCCTTCTCATGGATGC	0.448													71	137					0	0	0.000781405	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623513	21623513	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:21623513G>A	uc010tlp.1	-	1	672	c.672C>T	c.(670-672)GTC>GTT	p.V224V		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	224	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		AGTGAGTGACGACATGAGCAC	0.488													23	29					0	0	0.000720815	0	0
RIPK3	11035	broad.mit.edu	37	14	24806441	24806441	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:24806441C>T	uc001wpb.2	-	8	1336	c.1126G>A	c.(1126-1128)GAG>AAG	p.E376K	ADCY4_uc001wov.2_5'Flank|ADCY4_uc001wow.2_5'Flank|ADCY4_uc010toh.1_5'Flank|ADCY4_uc001wox.2_5'Flank|ADCY4_uc001woy.2_5'Flank|ADCY4_uc001woz.3_5'Flank|RIPK3_uc001wpa.2_Missense_Mutation_p.E176K|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_Missense_Mutation_p.E155K	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	376					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		ACCTGCTCCTCTTGTGCCCTG	0.522													43	82					0	0	0.000781405	0	0
ARHGAP5	394	broad.mit.edu	37	14	32562338	32562338	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:32562338C>T	uc001wrl.2	+	2	2702	c.2463C>T	c.(2461-2463)ATC>ATT	p.I821I	ARHGAP5_uc001wrm.2_Silent_p.I821I|ARHGAP5_uc001wrn.2_Silent_p.I821I|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	821					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTGATAAAATCATTGGTGAAA	0.353													15	64					0	0	0.000308642	0	0
SLC8A3	6547	broad.mit.edu	37	14	70522526	70522526	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:70522526G>A	uc001xly.2	-	4	2647	c.1893C>T	c.(1891-1893)CTC>CTT	p.L631L	SLC8A3_uc001xlu.2_Intron|SLC8A3_uc001xlv.2_Intron|SLC8A3_uc001xlw.2_Silent_p.L631L|SLC8A3_uc001xlx.2_Silent_p.L632L|SLC8A3_uc001xlz.2_Intron|SLC8A3_uc010ara.2_Intron|SLC8A3_uc001xma.2_Intron	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	631	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GAGATAACAGGAGCGCTGTTT	0.413													13	33					0	0	0.000308642	0	0
PSEN1	5663	broad.mit.edu	37	14	73685906	73685906	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:73685906C>T	uc001xnr.2	+	12	1597	c.1313C>T	c.(1312-1314)TCC>TTC	p.S438F	PSEN1_uc001xnv.2_Missense_Mutation_p.S434F|PSEN1_uc010ark.2_Missense_Mutation_p.S434F|PSEN1_uc001xnu.2_RNA	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	438	Required for interaction with CTNNB1.|Helical; (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		CTTCCAATCTCCATCACCTTT	0.393													89	151					0	0	0.000781405	0	0
KIAA0317	9870	broad.mit.edu	37	14	75142432	75142433	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:75142432_75142433CG>AT	uc001xqb.2	-	8	1554_1555	c.1049_1050CG>AT	c.(1048-1050)CCG>CAT	p.P350H	KIAA0317_uc010tut.1_Missense_Mutation_p.P189H|KIAA0317_uc001xqc.2_Missense_Mutation_p.P350H	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	350					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		ACACCTTCTTCGGTTTCTTCAC	0.51													9	364					0	0	6.4e-05	0	0
STON2	85439	broad.mit.edu	37	14	81744845	81744845	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:81744845C>T	uc010tvu.1	-	4	1011	c.810G>A	c.(808-810)ATG>ATA	p.M270I	STON2_uc001xvk.1_Missense_Mutation_p.M270I|STON2_uc010tvt.1_Missense_Mutation_p.M67I	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	270					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TAAATGATCCCATTGAATTAT	0.448													42	94					0	0	0.00148497	0	0
GPR65	8477	broad.mit.edu	37	14	88478080	88478080	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:88478080G>A	uc001xvv.2	+	2	1419	c.889G>A	c.(889-891)GGA>AGA	p.G297R		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	297	Cytoplasmic (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						AACCGAAACAGGAAGATATGA	0.348													26	40					0	0	0.000878237	0	0
CATSPERB	79820	broad.mit.edu	37	14	92091309	92091309	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:92091309C>T	uc001xzs.1	-	18	1925	c.1785G>A	c.(1783-1785)ACG>ACA	p.T595T	CATSPERB_uc010aub.1_Silent_p.T117T	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	595					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CTTTAGGAGTCGTATGTTGCA	0.343													12	36					0	0	0.000219431	0	0
KIAA1409	57578	broad.mit.edu	37	14	94041526	94041526	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:94041526G>A	uc001ybv.1	+	14	1745	c.1662G>A	c.(1660-1662)GGG>GGA	p.G554G	KIAA1409_uc001ybs.1_Silent_p.G554G	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	731						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AACTGGCAGGGAACCTTGCAT	0.383													17	25					0	0	0.00121646	0	0
SERPINA10	51156	broad.mit.edu	37	14	94754765	94754765	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:94754765G>A	uc001yct.2	-	3	1316	c.850C>T	c.(850-852)CGT>TGT	p.R284C	SERPINA10_uc001ycu.3_Missense_Mutation_p.R284C	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	284					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		ACATGACAACGAAAATTCTTG	0.507													18	41					0	0	0.00074312	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849309	94849309	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:94849309G>A	uc001ycx.3	-	2	527	c.266C>T	c.(265-267)TCC>TTC	p.S89F	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.S89F|SERPINA1_uc010aux.2_Missense_Mutation_p.S89F|SERPINA1_uc001ycy.3_Missense_Mutation_p.S89F|SERPINA1_uc010auy.2_Missense_Mutation_p.S89F|SERPINA1_uc001ycz.3_Missense_Mutation_p.S89F|SERPINA1_uc010auz.2_Missense_Mutation_p.S89F|SERPINA1_uc010ava.2_Missense_Mutation_p.S89F|SERPINA1_uc001ydb.3_Missense_Mutation_p.S89F|SERPINA1_uc010avb.2_Missense_Mutation_p.S89F|SERPINA1_uc001ydc.3_Missense_Mutation_p.S89F|SERPINA1_uc001yda.1_Missense_Mutation_p.S89F	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	89					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	GGTCCCCAGGGAGAGCATTGC	0.547									Alpha-1-Antitrypsin_Deficiency				32	72					0	0	0.000953801	0	0
DLK1	8788	broad.mit.edu	37	14	101200851	101200851	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:101200851G>A	uc001yhs.3	+	5	923	c.770G>A	c.(769-771)CGT>CAT	p.R257H	DLK1_uc001yhu.3_Intron	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	257	Extracellular (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				CAGGTCACCCGTCTGCCCAGC	0.652													12	45					0	0	0.000978159	0	0
ADAM6	8755	broad.mit.edu	37	14	106331449	106331449	+	RNA	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:106331449G>A	uc010tyt.1	-	3488		c.53226C>T			uc001yrs.2_5'Flank|uc001yrt.2_5'Flank|uc001yrw.1_5'Flank|uc001yrx.1_5'Flank|uc001yrz.1_5'Flank|uc001yse.2_5'Flank|uc001ysf.2_Intron|uc001ysj.2_5'Flank|uc001ysk.1_5'Flank|uc001ysl.1_5'Flank|uc001ysm.1_5'Flank|uc001ysn.1_5'UTR|uc001yso.1_Intron					Parts of antibodies, mostly variable regions.												0						CCCAGAGATCGAAGTACCAGT	0.612													9	9					0	0	0.000978159	0	0
ADAM6	8755	broad.mit.edu	37	14	106349677	106349677	+	RNA	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:106349677G>A	uc010tyt.1	-	3179		c.50149C>T								Parts of antibodies, mostly variable regions.												0						AGCCCCAGGAGAAGCAGGTGA	0.622													5	10					0	0	0.00116845	0	0
ADAM6	8755	broad.mit.edu	37	14	106586249	106586249	+	RNA	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:106586249G>A	uc010tyt.1	-	1286		c.27981C>T			uc001ysv.2_RNA					Parts of antibodies, mostly variable regions.												0						CACGGAGCCTGGATAGTATGT	0.517													27	50					0	0	0.00106085	0	0
LOC646214	646214	broad.mit.edu	37	15	21936481	21936481	+	RNA	SNP	C	A	A	rs61999618		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:21936481C>A	uc010tzj.1	-	1		c.4259G>T				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						TTTAAACCCCCAAAAGAGTAA	0.333													9	87					3.09899e-07	1.7369e-06	0.000274275	1	0
ATP10A	57194	broad.mit.edu	37	15	26107818	26107818	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:26107818G>A	uc010ayu.2	-	1	532	c.426C>T	c.(424-426)CAC>CAT	p.H142H	ATP10A_uc001zax.2_RNA	NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	142	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGCAGCCCAGGTGGTTGATCT	0.692													9	9					0	0	0.000673444	0	0
SLC12A6	9990	broad.mit.edu	37	15	34547529	34547529	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:34547529G>A	uc001zhw.2	-	7	974	c.810C>T	c.(808-810)CTC>CTT	p.L270L	SLC12A6_uc001zhv.2_Silent_p.L219L|SLC12A6_uc001zhx.2_Silent_p.L255L|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Silent_p.L211L|SLC12A6_uc001zib.2_Silent_p.L261L|SLC12A6_uc001zic.2_Silent_p.L270L|SLC12A6_uc010bau.2_Silent_p.L270L|SLC12A6_uc001zid.2_Silent_p.L211L|SLC12A6_uc001zhu.2_Silent_p.L82L	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	270					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GATAAAAGCAGAGGCCAACAG	0.443													17	97					0	0	0.000422831	0	0
IVD	3712	broad.mit.edu	37	15	40705279	40705279	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:40705279G>A	uc001zls.3	+	7	1120	c.786G>A	c.(784-786)AAG>AAA	p.K262K	IVD_uc001zlq.2_Silent_p.K232K|IVD_uc001zlr.2_5'Flank	NM_002225	NP_002216	P26440	IVD_HUMAN	isovaleryl Coenzyme A dehydrogenase isoform 1	259					leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		AAGACTGCAAGATTCCTGGTA	0.527													11	38					0	0	0.000978159	0	0
VPS18	57617	broad.mit.edu	37	15	41192838	41192838	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:41192838C>G	uc001zne.2	+	4	2161	c.1822C>G	c.(1822-1824)CGC>GGC	p.R608G		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	608					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TCACATCCCCCGCCAGCTTGT	0.627													3	75					0	0	0.00024832	0	0
EXD1	161829	broad.mit.edu	37	15	41483671	41483671	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:41483671G>A	uc001znk.2	-	8	850	c.659C>T	c.(658-660)TCC>TTC	p.S220F	EXD1_uc001znj.2_5'Flank|EXD1_uc010ucv.1_Missense_Mutation_p.S278F	NM_152596	NP_689809	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	220					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			ovary(1)	1						TTCTAGAAAGGAGAGATATTT	0.383													9	61					0	0	0.000673444	0	0
NUSAP1	51203	broad.mit.edu	37	15	41643263	41643263	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:41643263A>T	uc001zns.3	+	4	614	c.384A>T	c.(382-384)AGA>AGT	p.R128S	NUSAP1_uc001znq.3_5'UTR|NUSAP1_uc001znr.3_Missense_Mutation_p.R128S|NUSAP1_uc010bce.2_Missense_Mutation_p.R128S|NUSAP1_uc001znt.3_Missense_Mutation_p.R113S|NUSAP1_uc001znv.3_Missense_Mutation_p.R127S|NUSAP1_uc001znu.3_Missense_Mutation_p.R127S|NUSAP1_uc010ucw.1_Missense_Mutation_p.R105S|NUSAP1_uc001znw.3_5'UTR	NM_016359	NP_057443	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	128					cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding				0		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		AGGATCTCAGAGCTACTGCAA	0.378													15	21					0	0	0.000219431	0	0
EHD4	30844	broad.mit.edu	37	15	42193093	42193093	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:42193093G>A	uc001zot.2	-	6	1439	c.1376C>T	c.(1375-1377)TCG>TTG	p.S459L		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	459	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		ATTGATGGGCGACAGAGTGTA	0.602													8	39					0	0	0.000274275	0	0
DUOX2	50506	broad.mit.edu	37	15	45394069	45394069	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:45394069G>A	uc010bea.2	-	21	2976	c.2773C>T	c.(2773-2775)CAC>TAC	p.H925Y	DUOX2_uc001zun.2_Missense_Mutation_p.H925Y	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	925	EF-hand 3.|Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGCATGAAGTGAAAATCCTCC	0.572													12	40					0	0	0.000219431	0	0
DMXL2	23312	broad.mit.edu	37	15	51828531	51828531	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:51828531G>A	uc002abf.2	-	12	2371	c.2146C>T	c.(2146-2148)CAT>TAT	p.H716Y	DMXL2_uc010ufy.1_Missense_Mutation_p.H716Y|DMXL2_uc010bfa.2_Missense_Mutation_p.H716Y	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	716						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TTTGGGTCATGAAATGTACGA	0.393													81	75					0	0	0.000781405	0	0
CILP	8483	broad.mit.edu	37	15	65490866	65490866	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:65490866G>A	uc002aon.2	-	9	1939	c.1758C>T	c.(1756-1758)ATC>ATT	p.I586I		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	586					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						CCAGGGGGATGATGTTGGTCT	0.507													9	44					0	0	0.000442599	0	0
MYO9A	4649	broad.mit.edu	37	15	72227785	72227785	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:72227785G>A	uc002atl.3	-	17	2892	c.2419C>T	c.(2419-2421)CGC>TGC	p.R807C	MYO9A_uc010biq.2_Missense_Mutation_p.R427C|MYO9A_uc002atn.1_Missense_Mutation_p.R788C	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	807					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CTGCTCTGGCGAATCCCAGTT	0.388													64	29					0	0	0.000781405	0	0
HCN4	10021	broad.mit.edu	37	15	73624501	73624501	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:73624501C>T	uc002avp.2	-	3	2336	c.1342G>A	c.(1342-1344)GAC>AAC	p.D448N		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	448	Extracellular (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		ACCCAGCAGTCGTCAGGGAAG	0.622													34	28					0	0	0.00148497	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562412	75562412	+	Splice_Site	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:75562412G>A	uc002azs.1	+	18	1996	c.1919_splice	c.e18-1	p.D640_splice	uc002azu.1_5'Flank|uc010ulz.1_5'Flank	NM_001145224	NP_001138696	A6NDK9	GOG6C_HUMAN	golgi autoantigen, golgin subfamily a, 6D											ovary(1)	1						TCTCTCCGAAGATTTTTATGA	0.637													8	52					0	0	0.000878237	0	0
C15orf27	123591	broad.mit.edu	37	15	76494549	76494549	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:76494549C>T	uc002bbq.2	+	10	1120	c.965C>T	c.(964-966)ACG>ATG	p.T322M	C15orf27_uc010bkp.2_Missense_Mutation_p.T138M|C15orf27_uc002bbr.2_Missense_Mutation_p.T138M|C15orf27_uc002bbs.2_Translation_Start_Site	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	322						integral to membrane					0						GTAGAAGCCACGATGAAGGAC	0.532													35	32					0	0	0.000374591	0	0
ACAN	176	broad.mit.edu	37	15	89400699	89400699	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:89400699G>A	uc010upo.1	+	12	5257	c.4883G>A	c.(4882-4884)GGA>GAA	p.G1628E	ACAN_uc010upp.1_Missense_Mutation_p.G1628E|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1628					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTTCCCTCTGGATTTAGTGGT	0.532													25	144					0	0	0.00106085	0	0
ANPEP	290	broad.mit.edu	37	15	90328627	90328627	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:90328627C>T	uc002bop.3	-	21	3149	c.2857G>A	c.(2857-2859)GAG>AAG	p.E953K		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	953	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TCCTTGTTCTCCTTCACCCAC	0.572													16	108					0	0	0.00074312	0	0
ITFG3	83986	broad.mit.edu	37	16	314837	314837	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:314837C>T	uc002cgf.2	+	13	1670	c.1475C>T	c.(1474-1476)GCC>GTC	p.A492V	ITFG3_uc002cgg.2_Missense_Mutation_p.A492V|ITFG3_uc010uud.1_Intron|ITFG3_uc002cgh.2_Missense_Mutation_p.A492V	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	492	Extracellular (Potential).					integral to membrane		p.A492T(1)		central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				AGCCGCCACGCCGCCTACATC	0.672													8	19					0	0	0.000442599	0	0
C16orf11	146325	broad.mit.edu	37	16	613648	613648	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:613648C>T	uc002chk.2	+	2	633	c.354C>T	c.(352-354)GTC>GTT	p.V118V		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	118	Pro-rich.									central_nervous_system(1)	1						ACCTCGTGGTCGCCGACATCC	0.741													3	2					0	0	6.4e-05	0	0
PKD1	5310	broad.mit.edu	37	16	2149654	2149654	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:2149654G>A	uc002cos.1	-	30	10250	c.10041C>T	c.(10039-10041)TCC>TCT	p.S3347S	PKD1_uc002cot.1_Silent_p.S3347S|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3347	Cytoplasmic (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCTTGCTCCGGGACATCCGGA	0.647													3	5					0	0	0.000602214	0	0
NLRC3	197358	broad.mit.edu	37	16	3614061	3614061	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:3614061C>T	uc010btn.2	-	5	1288	c.877G>A	c.(877-879)GAG>AAG	p.E293K		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	293	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ACCTTGATCTCCTCCTCGTTA	0.607													9	34					0	0	0.000274275	0	0
C16orf71	146562	broad.mit.edu	37	16	4786528	4786528	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:4786528G>A	uc002cxn.2	+	2	475	c.13G>A	c.(13-15)GAT>AAT	p.D5N	ANKS3_uc002cxj.1_5'Flank|ANKS3_uc002cxk.2_5'Flank|ANKS3_uc002cxl.2_5'Flank|ANKS3_uc010uxs.1_5'Flank|ANKS3_uc002cxm.2_5'Flank	NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	5										central_nervous_system(1)	1						GGCATCCAACGATAAAGGCAT	0.622													12	30					0	0	0.000308642	0	0
ABAT	18	broad.mit.edu	37	16	8829605	8829605	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:8829605C>T	uc002czc.3	+	2	175	c.9C>T	c.(7-9)TCC>TCT	p.S3S	ABAT_uc002czd.3_Silent_p.S3S|ABAT_uc010buh.2_5'UTR|ABAT_uc010bui.2_Silent_p.S3S	NM_020686	NP_065737	P80404	GABT_HUMAN	4-aminobutyrate aminotransferase precursor	3					behavioral response to cocaine|gamma-aminobutyric acid catabolic process|neurotransmitter catabolic process|neurotransmitter secretion	4-aminobutyrate transaminase complex|mitochondrial matrix	(S)-3-amino-2-methylpropionate transaminase activity|4-aminobutyrate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|succinate-semialdehyde dehydrogenase binding			upper_aerodigestive_tract(1)	1					Divalproex sodium(DB00510)|Isoniazid(DB00951)|L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)|Tiagabine(DB00906)|Valproic Acid(DB00313)|Vigabatrin(DB01080)	TCATGGCCTCCATGTTGCTCG	0.592													4	9					0	0	0.00116845	0	0
SNX29	92017	broad.mit.edu	37	16	12618696	12618696	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:12618696C>T	uc002dby.3	+	13	1217	c.1161C>T	c.(1159-1161)TTC>TTT	p.F387F		NM_001080530	NP_001073999	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	387	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1						TGCCCTTCTTCGTGTAAGTAC	0.572													17	75					0	0	0.000422831	0	0
ACSM2B	348158	broad.mit.edu	37	16	20570742	20570742	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:20570742G>A	uc002dhj.3	-	4	415	c.205C>T	c.(205-207)CTG>TTG	p.L69L	ACSM2B_uc002dhk.3_Silent_p.L69L|ACSM2B_uc010bwf.1_Silent_p.L69L	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	69					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						ACCCACCACAGGGCTGGGCTT	0.527													7	14					0	0	0.000978159	0	0
SCNN1G	6340	broad.mit.edu	37	16	23226713	23226713	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:23226713C>T	uc002dlm.1	+	13	2012	c.1873C>T	c.(1873-1875)CCC>TCC	p.P625S		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	625	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	CACACCGCCCCCCAAATACAA	0.552													15	52					0	0	0.000422831	0	0
ERN2	10595	broad.mit.edu	37	16	23716310	23716310	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:23716310G>A	uc002dma.3	-	8	1061	c.892C>T	c.(892-894)CGA>TGA	p.R298*	ERN2_uc010bxp.2_Nonsense_Mutation_p.R298*|ERN2_uc010bxq.1_Nonsense_Mutation_p.R106*	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	250	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AGAGTGTCTCGAGCCAGCGTG	0.672													7	49					0	0	8.12818e-05	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24931540	24931540	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:24931540G>A	uc002dnb.2	-	20	2650	c.2557C>T	c.(2557-2559)CCT>TCT	p.P853S	ARHGAP17_uc002dmx.2_3'UTR|ARHGAP17_uc002dmw.2_3'UTR|ARHGAP17_uc002dmy.2_Missense_Mutation_p.P298S|ARHGAP17_uc002dmz.2_Missense_Mutation_p.P377S|ARHGAP17_uc002dna.2_Missense_Mutation_p.P580S|ARHGAP17_uc002dnc.2_Missense_Mutation_p.P775S|ARHGAP17_uc010vcf.1_Missense_Mutation_p.P596S|ARHGAP17_uc002dnd.1_RNA|ARHGAP17_uc002dne.1_Silent_p.F110F	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	853					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TGCATTTCAGGAAAGATGCTG	0.527													24	85					0	0	0.00047179	0	0
ITGAL	3683	broad.mit.edu	37	16	30507776	30507776	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:30507776T>A	uc002dyi.3	+	15	1897	c.1721T>A	c.(1720-1722)GTG>GAG	p.V574E	ITGAL_uc002dyj.3_Missense_Mutation_p.V491E|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	574	FG-GAP 7.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GGGACCCAAGTGCTCTCAGGA	0.572													14	54					0	0	0.00121646	0	0
CNOT1	23019	broad.mit.edu	37	16	58577803	58577803	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:58577803G>A	uc002env.2	-	31	4435	c.4142C>T	c.(4141-4143)CCC>CTC	p.P1381L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.P1376L|CNOT1_uc002enx.2_Missense_Mutation_p.P1381L|CNOT1_uc010vik.1_Missense_Mutation_p.P338L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1381					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CTGAAACAAGGGAATCTGGGG	0.458													25	19					0	0	0.00106085	0	0
DPEP2	64174	broad.mit.edu	37	16	68021586	68021586	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:68021586G>A	uc010cey.2	-	10	1448	c.1284C>T	c.(1282-1284)TCC>TCT	p.S428S	DPEP2_uc002evd.3_Silent_p.S433S|DPEP2_uc002eve.2_Silent_p.S428S|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	428					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		GTGAGAGGTCGGAGTGGCAGG	0.547													28	37					0	0	0.00178596	0	0
PMFBP1	83449	broad.mit.edu	37	16	72184683	72184683	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:72184683C>T	uc002fcc.3	-	5	632	c.460G>A	c.(460-462)GGG>AGG	p.G154R	PMFBP1_uc002fcd.2_Missense_Mutation_p.G154R|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.G9R	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	154										ovary(2)	2		Ovarian(137;0.179)				AGCTTCTCCCCTGTGTTCTCG	0.493													36	45					0	0	0.00170553	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77331198	77331198	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:77331198G>A	uc002ffc.3	-	18	3208	c.2789C>T	c.(2788-2790)TCC>TTC	p.S930F	ADAMTS18_uc010chc.1_Missense_Mutation_p.S518F|ADAMTS18_uc002ffe.1_Missense_Mutation_p.S626F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	930					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AGCCGGGCAGGAGAAAGCGTT	0.403													25	40					0	0	0.000878237	0	0
VAT1L	57687	broad.mit.edu	37	16	77918616	77918616	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:77918616C>T	uc002ffg.1	+	7	1091	c.994C>T	c.(994-996)CGG>TGG	p.R332W		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	332							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GGGCCTCATTCGGGGAGTGGT	0.512													12	14					0	0	0.00136819	0	0
ATMIN	23300	broad.mit.edu	37	16	81077419	81077419	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:81077419C>G	uc002ffz.1	+	4	1334	c.1316C>G	c.(1315-1317)TCT>TGT	p.S439C	ATMIN_uc002fga.2_Missense_Mutation_p.S281C|ATMIN_uc010vnn.1_Missense_Mutation_p.S210C|ATMIN_uc002fgb.1_Missense_Mutation_p.S281C	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	439	Required for formation of RAD51 foci.				response to DNA damage stimulus	nucleus	zinc ion binding				0						TCTGTGTCGTCTTGTTCTCAA	0.413													27	67					0	0	0.000878237	0	0
PKD1L2	114780	broad.mit.edu	37	16	81183453	81183453	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:81183453C>T	uc002fgh.1	-	28	4595	c.4595G>A	c.(4594-4596)GGA>GAA	p.G1532E	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1532	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAGATGTGTCCATCCTGGAA	0.592													6	24					0	0	8.12818e-05	0	0
PLCG2	5336	broad.mit.edu	37	16	81819628	81819628	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:81819628G>A	uc002fgt.2	+	2	186	c.34G>A	c.(34-36)GAA>AAA	p.E12K	PLCG2_uc010chg.1_Missense_Mutation_p.E12K	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	12					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						TTCCCTTGCGGAATATGAGAA	0.552													18	41					0	0	0.000566183	0	0
KCNG4	93107	broad.mit.edu	37	16	84256488	84256488	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:84256488C>T	uc010voc.1	-	3	1016	c.895G>A	c.(895-897)GAC>AAC	p.D299N		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	299	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						GCCAGGATGTCGATGATGTTC	0.627													6	12					0	0	0.000442599	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84902464	84902464	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:84902464C>T	uc010voh.1	+	8	1088	c.861C>T	c.(859-861)GTC>GTT	p.V287V	CRISPLD2_uc010vog.1_Intron|CRISPLD2_uc002fio.2_Silent_p.V286V|CRISPLD2_uc002fim.2_Silent_p.V287V|CRISPLD2_uc002fin.3_Silent_p.V287V	NM_031476	NP_113664	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain	287	LCCL 1.					extracellular region|transport vesicle					0						TAGCCCAAGTCGTCAGATGTG	0.547													6	39					0	0	8.12818e-05	0	0
JPH3	57338	broad.mit.edu	37	16	87677904	87677904	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:87677904C>T	uc002fkd.2	+	2	677	c.423C>T	c.(421-423)GGC>GGT	p.G141G	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	141	MORN 6.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TGCGCCAGGGCTACGGCGTCC	0.677													26	32					0	0	0.00127121	0	0
CA5A	763	broad.mit.edu	37	16	87938439	87938439	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:87938439C>T	uc002fkn.1	-	3	468	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	138					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GAGCCCCCCTCGTTCACTGCT	0.547													15	50					0	0	0.000308642	0	0
APRT	353	broad.mit.edu	37	16	88876893	88876893	+	Missense_Mutation	SNP	G	C	C	rs3169258		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:88876893G>C	uc002flv.2	-	3	294	c.259C>G	c.(259-261)CGA>GGA	p.R87G	APRT_uc002flw.2_Missense_Mutation_p.R87G	NM_000485	NP_000476	P07741	APT_HUMAN	adenine phosphoribosyltransferase isoform a	87					purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	CCCCGCTTTCGGATGAGCACG	0.647													10	15					0	0	0.000673444	0	0
DEF8	54849	broad.mit.edu	37	16	90025448	90025448	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr16:90025448C>T	uc002fpn.1	+	6	671	c.582C>T	c.(580-582)ATC>ATT	p.I194I	DEF8_uc002fpl.2_Silent_p.I133I|DEF8_uc002fpm.2_Silent_p.I133I|DEF8_uc002fpo.1_Silent_p.I133I|DEF8_uc002fpp.1_Silent_p.I123I|DEF8_uc010vpq.1_Silent_p.I73I|DEF8_uc010vpr.1_Silent_p.I133I	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	194					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		AGCCAAACATCCGAGTGCTCC	0.557													46	60					0	0	0.000781405	0	0
OR1A1	8383	broad.mit.edu	37	17	3119386	3119386	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:3119386C>T	uc010vrc.1	+	1	472	c.472C>T	c.(472-474)CCC>TCC	p.P158S		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CAATGCCCTCCCCCACACTCT	0.512													22	46					0	0	0.000229342	0	0
NLRP1	22861	broad.mit.edu	37	17	5445200	5445200	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:5445200C>T	uc002gci.2	-	6	3231	c.2676G>A	c.(2674-2676)CCG>CCA	p.P892P	NLRP1_uc002gcg.1_Silent_p.P892P|NLRP1_uc002gck.2_Silent_p.P892P|NLRP1_uc002gcj.2_Silent_p.P892P|NLRP1_uc002gcl.2_Silent_p.P892P|NLRP1_uc002gch.3_Silent_p.P892P|NLRP1_uc010clh.2_Silent_p.P892P	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	892					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCTTGCAGCTCGGCTGTCTCA	0.587													16	39					0	0	0.00074312	0	0
TEKT1	83659	broad.mit.edu	37	17	6716370	6716370	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:6716370G>A	uc002gdt.2	-	6	742	c.632C>T	c.(631-633)TCC>TTC	p.S211F	TEKT1_uc010vth.1_Missense_Mutation_p.S65F	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	211					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				CAGACTCACGGAGCTGAAACA	0.547													13	23					0	0	0.000308642	0	0
TEKT1	83659	broad.mit.edu	37	17	6718550	6718550	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:6718550G>A	uc002gdt.2	-	5	671	c.561C>T	c.(559-561)ATC>ATT	p.I187I	TEKT1_uc010vth.1_Silent_p.I41I	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	187					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				GCGAGAAGCAGATATCATCTA	0.488													40	86					0	0	0.000509022	0	0
BCL6B	255877	broad.mit.edu	37	17	6929847	6929847	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:6929847C>T	uc002geg.2	+	6	1018	c.961C>T	c.(961-963)CCT>TCT	p.P321S	BCL6B_uc010clt.1_Missense_Mutation_p.P322S	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	321						nucleus	zinc ion binding			skin(1)	1						CTCCTTGGTTCCTGGGGACGA	0.567													40	80					0	0	0.000374591	0	0
MYH8	4626	broad.mit.edu	37	17	10304912	10304912	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:10304912A>G	uc002gmm.2	-	23	2974	c.2879T>C	c.(2878-2880)CTT>CCT	p.L960P	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	960	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGTCAGCTCAAGGTCATCAAT	0.443									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				108	187					0	0	0.000781405	0	0
MYH1	4619	broad.mit.edu	37	17	10400637	10400637	+	Missense_Mutation	SNP	C	T	T	rs139013228		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:10400637C>T	uc002gmo.2	-	32	4592	c.4498G>A	c.(4498-4500)GAA>AAA	p.E1500K	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1500	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.E1500K(1)		ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TTCAAGGTTTCAAGTTGGTCT	0.328													32	54					0	0	0.00111076	0	0
MYH1	4619	broad.mit.edu	37	17	10408497	10408497	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:10408497C>T	uc002gmo.2	-	21	2512	c.2418G>A	c.(2416-2418)CAG>CAA	p.Q806Q	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	806	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCACCATTTTCTGGTACTCCA	0.428													23	45					0	0	0.000586117	0	0
MYH3	4621	broad.mit.edu	37	17	10532921	10532921	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:10532921G>A	uc002gmq.1	-	39	5866	c.5789C>T	c.(5788-5790)TCC>TTC	p.S1930F		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1930	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CACCCTGCTGGAGGTGAAGTC	0.463													19	55					0	0	0.000229342	0	0
MYOCD	93649	broad.mit.edu	37	17	12656204	12656204	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:12656204G>A	uc002gnn.2	+	10	1898	c.1599G>A	c.(1597-1599)TGG>TGA	p.W533*	MYOCD_uc002gno.2_Nonsense_Mutation_p.W533*|MYOCD_uc002gnp.1_Nonsense_Mutation_p.W437*|MYOCD_uc002gnq.2_Nonsense_Mutation_p.W252*	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	533	Potential.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AACTCACCTGGAAACTCCAGC	0.537													17	34					0	0	0.00074312	0	0
RICH2	9912	broad.mit.edu	37	17	12888042	12888042	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:12888042C>T	uc002gnr.3	+	20	2461	c.2134C>T	c.(2134-2136)CCC>TCC	p.P712S	RICH2_uc010vvk.1_Missense_Mutation_p.P712S|RICH2_uc010vvl.1_Missense_Mutation_p.P706S|RICH2_uc002gns.3_Missense_Mutation_p.P506S|RICH2_uc010vvm.1_Missense_Mutation_p.P706S|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	712					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TGCAGCTCCTCCCCTGGCCTC	0.647													12	12					0	0	0.00136819	0	0
TRIM16	10626	broad.mit.edu	37	17	15517324	15517324	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:15517324G>A	uc002gor.1	-	9	1961	c.1624C>T	c.(1624-1626)CGG>TGG	p.R542W	CDRT1_uc002gov.3_Missense_Mutation_p.R232W			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GATATACACCGGAGTGAATTC	0.488													25	80					0	0	0.000720815	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612455	16612455	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:16612455C>T	uc002gqk.1	+	5	1160	c.1084C>T	c.(1084-1086)CCT>TCT	p.P362S	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	362											0						CGAGACATTTCCTGAACAAAA	0.378													46	70					0	0	0.000781405	0	0
MYO15A	51168	broad.mit.edu	37	17	18051410	18051410	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:18051410G>A	uc010vxh.1	+	30	6915	c.6577G>A	c.(6577-6579)GGC>AGC	p.G2193S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	2193	Tail.|MyTH4 1.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCAGGCCATGGGCCGGGCCCA	0.627													22	39					0	0	0.000375601	0	0
LLGL1	3996	broad.mit.edu	37	17	18140988	18140988	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:18140988C>T	uc002gsp.2	+	14	1866	c.1805C>T	c.(1804-1806)ACC>ATC	p.T602I		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	602	WD 10.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GCTGCTGTAACCGCTGTCACA	0.672													12	22					0	0	0.000978159	0	0
TOP3A	7156	broad.mit.edu	37	17	18183948	18183948	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:18183948G>A	uc002gsx.1	-	17	2275	c.2046C>T	c.(2044-2046)TTC>TTT	p.F682F	TOP3A_uc010cpz.1_Silent_p.F134F|TOP3A_uc010vxr.1_Silent_p.F212F|TOP3A_uc002gsw.1_Silent_p.F134F|TOP3A_uc010vxs.1_Silent_p.F580F	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	682	C4-type (Potential).				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GACACTCTGGGAAACCCATGC	0.577													15	33					0	0	0.00074312	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565293	18565293	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:18565293G>A	uc010vyd.1	-	5	1777	c.1526C>T	c.(1525-1527)TCT>TTT	p.S509F		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	509	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCTGATGAGAGATGAACTGCA	0.353													11	43					0	0	0.000308642	0	0
ALDH3A1	218	broad.mit.edu	37	17	19646717	19646717	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:19646717C>T	uc010cqu.2	-	2	552	c.222G>A	c.(220-222)ATG>ATA	p.M74I	ALDH3A1_uc010vzd.1_Missense_Mutation_p.M74I|ALDH3A1_uc002gwj.2_Missense_Mutation_p.M74I|ALDH3A1_uc010cqv.2_Missense_Mutation_p.M74I|ALDH3A1_uc002gwk.2_5'UTR|ALDH3A1_uc002gwl.1_Missense_Mutation_p.M1I	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	74					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	GCTTCTGGATCATGTACTCGA	0.612													43	81					0	0	0.000781405	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319617	21319617	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:21319617C>T	uc002gyv.1	+	3	1668	c.963C>T	c.(961-963)ATC>ATT	p.I321I		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	321	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CCAATGAGATCCTGTGGGGTC	0.577										Prostate(3;0.18)			28	164					0	0	0.000878237	0	0
Unknown	0	broad.mit.edu	37	17	21730947	21730947	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:21730947C>T	uc002gyy.3	+	2	374	c.249C>T	c.(247-249)ACC>ACT	p.T83T						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		TCGTGAAGACCCTGACCGGCA	0.552													8	33					0	0	0.000151284	0	0
PIPOX	51268	broad.mit.edu	37	17	27383231	27383231	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:27383231C>T	uc002hdr.1	+	8	1407	c.1081C>T	c.(1081-1083)CTG>TTG	p.L361L		NM_016518	NP_057602	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	361					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity				0	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	GGGGAAGATCCTGTATGAATT	0.522													18	46					0	0	0.000958276	0	0
TMEM132E	124842	broad.mit.edu	37	17	32963172	32963172	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:32963172C>T	uc002hif.2	+	9	2182	c.1854C>T	c.(1852-1854)ATC>ATT	p.I618I		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	618	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GCCACACCATCCTAGCCACCA	0.622													10	12					0	0	0.000151284	0	0
ACACA	31	broad.mit.edu	37	17	35620751	35620751	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:35620751G>C	uc002hnm.2	-	11	1246	c.1055C>G	c.(1054-1056)GCC>GGC	p.A352G	ACACA_uc002hnk.2_Missense_Mutation_p.A274G|ACACA_uc002hnl.2_Missense_Mutation_p.A294G|ACACA_uc002hnn.2_Missense_Mutation_p.A352G|ACACA_uc002hno.2_Missense_Mutation_p.A389G|ACACA_uc010cuz.2_Missense_Mutation_p.A352G	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	352	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	AGATTGTTTGGCTAGTCTCAT	0.398													32	36					0	0	0.000692331	0	0
KRT24	192666	broad.mit.edu	37	17	38857515	38857515	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:38857515C>T	uc002hvd.2	-	3	789	c.732G>A	c.(730-732)GTG>GTA	p.V244V		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	244	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TGTCAGCCTCCACGCTCTGCC	0.542													14	13					0	0	0.000151284	0	0
KRT34	3885	broad.mit.edu	37	17	39538518	39538518	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:39538518G>A	uc002hwm.2	-	1	119	c.107C>T	c.(106-108)TCC>TTC	p.S36F		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	36	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				ACAGGTAATGGAAAAGCAGGT	0.582													23	26					0	0	0.00047179	0	0
CNTD1	124817	broad.mit.edu	37	17	40958834	40958834	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:40958834A>C	uc002ibm.3	+	5	955	c.723A>C	c.(721-723)CAA>CAC	p.Q241H	CNTD1_uc010wha.1_Missense_Mutation_p.Q158H	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	241										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GTCAGCTGCAAGGGTAAGACA	0.517													10	11					0	0	0.000442599	0	0
TTLL6	284076	broad.mit.edu	37	17	46846537	46846537	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:46846537G>A	uc010wlo.1	-	16	2525	c.2490C>T	c.(2488-2490)CTC>CTT	p.L830L	TTLL6_uc002iob.2_Silent_p.L523L|TTLL6_uc010dbi.2_Intron|TTLL6_uc002ioc.2_Silent_p.L583L|TTLL6_uc002iod.2_Intron	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	782						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						TCTGCAAGAGGAGGGAGGACA	0.567													15	12					0	0	0.000219431	0	0
FAM104A	84923	broad.mit.edu	37	17	71228278	71228278	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:71228278C>T	uc002jji.3	-	1	256	c.168G>A	c.(166-168)GCG>GCA	p.A56A	FAM104A_uc002jjj.3_Silent_p.A56A|C17orf80_uc010wqu.1_5'Flank|C17orf80_uc010dfj.2_5'Flank|C17orf80_uc002jjk.1_5'Flank|C17orf80_uc002jjm.3_5'Flank|C17orf80_uc002jjl.3_5'Flank	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	56											0			LUSC - Lung squamous cell carcinoma(166;0.197)			TACGCGGCGCCGCTCCGCGAA	0.701													8	20					0	0	0.000442599	0	0
SDK2	54549	broad.mit.edu	37	17	71346892	71346892	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:71346892G>A	uc010dfm.2	-	42	5796	c.5796C>T	c.(5794-5796)TTC>TTT	p.F1932F	SDK2_uc002jjt.3_Silent_p.F1072F	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1932	Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TGACCACCAAGAACCACCACT	0.552													23	59					0	0	0.00106085	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436352	72436352	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:72436352G>A	uc002jks.2	+	1	476	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	GPRC5C_uc002jkp.2_Missense_Mutation_p.R191Q|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Missense_Mutation_p.R158Q|GPRC5C_uc002jkt.2_Missense_Mutation_p.R146Q|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	146	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						TTCCTGGCCCGGAAGAACCAC	0.587													38	59					0	0	0.000437636	0	0
UNC13D	201294	broad.mit.edu	37	17	73827358	73827358	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:73827358G>A	uc002jpp.2	-	26	2899	c.2519C>T	c.(2518-2520)TCC>TTC	p.S840F	UNC13D_uc010wsk.1_Missense_Mutation_p.S840F	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	840	MHD2.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGAAGCCAGGGATGAGCTGCG	0.637									Familial_Hemophagocytic_Lymphohistiocytosis				8	41					0	0	0.000442599	0	0
ENGASE	64772	broad.mit.edu	37	17	77082081	77082081	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:77082081C>T	uc002jwv.2	+	14	1890	c.1882C>T	c.(1882-1884)CGC>TGC	p.R628C	ENGASE_uc002jww.2_Missense_Mutation_p.R333C	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	628						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						CTCTCACATCCGCTGGCAGCC	0.672													9	31					0	0	0.000274275	0	0
CBX8	57332	broad.mit.edu	37	17	77768994	77768995	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:77768994_77768995GG>AA	uc002jxd.1	-	5	702_703	c.609_610CC>TT	c.(607-612)CCCCGG>CCTTGG	p.R204W		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	204					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AGCTCCTTCCGGGGCTTGGGGC	0.599													9	27					0	0	6.4e-05	0	0
DSG3	1830	broad.mit.edu	37	18	29037053	29037053	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr18:29037053G>A	uc002kws.2	+	3	291	c.182G>A	c.(181-183)GGA>GAA	p.G61E		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	61	Extracellular (Potential).|Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCAGAGAAGGAGAAGATAAC	0.338													18	22					0	0	0.000566183	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555292	44555292	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr18:44555292C>T	uc010xdb.1	-	1	1158	c.922G>A	c.(922-924)GAA>AAA	p.E308K	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	308	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						AAAGCAGCTTCCTCCTGGAGC	0.637													26	778					0	0	0.001512	0	0
DCC	1630	broad.mit.edu	37	18	50985644	50985644	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr18:50985644G>A	uc002lfe.1	+	24	4022	c.3435G>A	c.(3433-3435)CAG>CAA	p.Q1145Q	DCC_uc010dpf.1_Silent_p.Q780Q	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1145	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGGCAGCCAGAAGGACCTCC	0.488													25	15					0	0	0.00106085	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024592	55024592	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr18:55024592C>T	uc002lgn.2	+	3	1108	c.751C>T	c.(751-753)CAC>TAC	p.H251Y		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	251	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		ATTTTTCTTCCACACTTCAGC	0.403													32	22					0	0	0.000339439	0	0
MOBKL2A	126308	broad.mit.edu	37	19	2076834	2076834	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:2076834G>A	uc002luu.2	-	2	759	c.600C>T	c.(598-600)ATC>ATT	p.I200I	MOBKL2A_uc002luv.2_Silent_p.I200I	NM_130807	NP_570719	Q96BX8	MOL2A_HUMAN	MOB-LAK	200						intracellular	metal ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTGGTGTCGATGAGGCCGA	0.637													8	4					0	0	0.000157383	0	0
FZR1	51343	broad.mit.edu	37	19	3527749	3527749	+	Silent	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:3527749C>A	uc010dtk.2	+	6	625	c.591C>A	c.(589-591)TCC>TCA	p.S197S	FZR1_uc002lxt.2_Silent_p.S197S|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	197	WD 1.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGGTCGTCCCTCAATGTGC	0.632													12	26					4.3838e-07	2.44929e-06	0.000151284	1	0
ARHGEF18	23370	broad.mit.edu	37	19	7518552	7518552	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:7518552C>T	uc002mgi.2	+	7	1744	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L	ARHGEF18_uc010xjm.1_Silent_p.L339L|ARHGEF18_uc002mgh.2_Silent_p.L339L|ARHGEF18_uc002mgj.1_Silent_p.L140L	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	497	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				AGCGGCAGCTCCACCTGGAGG	0.582													8	53					0	0	0.000442599	0	0
EVI5L	115704	broad.mit.edu	37	19	7913942	7913942	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:7913942C>T	uc002min.2	+	4	617	c.463C>T	c.(463-465)CGC>TGC	p.R155C	EVI5L_uc010xjz.1_Missense_Mutation_p.R155C|EVI5L_uc002mio.1_5'Flank	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	155	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GAAGCTGATCCGCAGGGACAT	0.617													7	7					0	0	8.12818e-05	0	0
ACTL9	284382	broad.mit.edu	37	19	8807924	8807924	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:8807924C>T	uc002mkl.2	-	1	1249	c.1128G>A	c.(1126-1128)AGG>AGA	p.R376R		NM_178525	NP_848620	Q8TC94	ACTL9_HUMAN	actin-like 9	376						cytoplasm|cytoskeleton				large_intestine(2)|pancreas(1)	3						CGGAGAAATTCCTGGTGGGCT	0.667													6	13					0	0	0.000673444	0	0
MUC16	94025	broad.mit.edu	37	19	8995663	8995663	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:8995663C>T	uc002mkp.2	-	63	41529	c.41325G>A	c.(41323-41325)AAG>AAA	p.K13775K	MUC16_uc010dwi.2_Intron|MUC16_uc010dwj.2_Silent_p.K592K|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGCTGGAGTCTTAGATGCTC	0.488													5	18					0	0	0.000602214	0	0
MUC16	94025	broad.mit.edu	37	19	9060353	9060353	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:9060353C>T	uc002mkp.2	-	3	27297	c.27093G>A	c.(27091-27093)ACG>ACA	p.T9031T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9033	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTCCTCAATCGTGGCACTAG	0.542													26	28					0	0	0.000586117	0	0
MUC16	94025	broad.mit.edu	37	19	9061972	9061972	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:9061972C>T	uc002mkp.2	-	3	25678	c.25474G>A	c.(25474-25476)GAA>AAA	p.E8492K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8494	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGGCACTTTCTGCTGATTCT	0.498													43	118					0	0	0.000589545	0	0
MUC16	94025	broad.mit.edu	37	19	9076695	9076695	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:9076695G>A	uc002mkp.2	-	3	10955	c.10751C>T	c.(10750-10752)TCT>TTT	p.S3584F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3585	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTGTGGAAGACCAGGTGGA	0.493													21	68					0	0	0.000229342	0	0
MUC16	94025	broad.mit.edu	37	19	9084523	9084523	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:9084523G>A	uc002mkp.2	-	1	7496	c.7292C>T	c.(7291-7293)TCC>TTC	p.S2431F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2431	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGTTACTGGAAACAGATGG	0.512													17	18					0	0	0.00121646	0	0
OR7D4	125958	broad.mit.edu	37	19	9325330	9325330	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:9325330A>G	uc002mla.1	-	1	184	c.184T>C	c.(184-186)TTC>CTC	p.F62L		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TTGGAGAGGAAGAAGTACATG	0.542													13	41					0	0	0.000219431	0	0
COL5A3	50509	broad.mit.edu	37	19	10116637	10116637	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:10116637G>A	uc002mmq.1	-	3	358	c.272C>T	c.(271-273)TCC>TTC	p.S91F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	91	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GATCAGCAAGGAGAAGTTCTC	0.617													17	23					0	0	0.00074312	0	0
LDLR	3949	broad.mit.edu	37	19	11210922	11210922	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:11210922G>A	uc002mqk.3	+	2	259	c.91G>A	c.(91-93)GAG>AAG	p.E31K	LDLR_uc010xlk.1_Missense_Mutation_p.E31K|LDLR_uc010xll.1_Missense_Mutation_p.E31K|LDLR_uc010xlm.1_Missense_Mutation_p.R5Q|LDLR_uc010xln.1_Missense_Mutation_p.E31K|LDLR_uc010xlo.1_Missense_Mutation_p.E31K	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	31	Extracellular (Potential).|LDL-receptor class A 1.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CGAAAGAAACGAGTTCCAGTG	0.532													45	164					0	0	0.000781405	0	0
OR10H5	284433	broad.mit.edu	37	19	15905589	15905589	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:15905589C>T	uc010xos.1	+	1	731	c.731C>T	c.(730-732)TCT>TTT	p.S244F		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACCTGTGCCTCTCACCTCACT	0.552													14	18					0	0	0.000295444	0	0
KCNN1	3780	broad.mit.edu	37	19	18085944	18085944	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:18085944C>T	uc002nht.2	+	4	756	c.446C>T	c.(445-447)TCC>TTC	p.S149F	KCNN1_uc010xqa.1_Missense_Mutation_p.S149F	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	149	Helical; Name=Segment S2; (Potential).				synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						ATCAGCCTCTCCACGGCCATC	0.597													7	44					0	0	0.000274275	0	0
PDE4C	5143	broad.mit.edu	37	19	18331715	18331715	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:18331715G>T	uc010xqc.1	-	5	1044	c.564C>A	c.(562-564)AAC>AAA	p.N188K	PDE4C_uc002nik.3_Missense_Mutation_p.N188K|PDE4C_uc002nil.3_Missense_Mutation_p.N188K|PDE4C_uc002nif.3_Intron|PDE4C_uc002nig.3_Intron|PDE4C_uc002nih.3_Intron|PDE4C_uc010ebk.2_Missense_Mutation_p.N82K|PDE4C_uc002nii.3_Missense_Mutation_p.N156K|PDE4C_uc010ebl.2_5'UTR|PDE4C_uc010xqd.1_Intron|PDE4C_uc010ebm.1_Intron|PDE4C_uc002nim.1_Intron	NM_001098819	NP_001092289	Q08493	PDE4C_HUMAN	phosphodiesterase 4C isoform PDE4C-2	188					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|skin(2)|central_nervous_system(1)	5					Dyphylline(DB00651)	TGGATGAAGGGTTTCCGACGG	0.652													4	18					0.000602214	0.00332808	0.000602214	1	0
APLP1	333	broad.mit.edu	37	19	36369521	36369521	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:36369521G>A	uc002oce.2	+	14	1750	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	APLP1_uc010xsz.1_Missense_Mutation_p.E499K|APLP1_uc002ocf.2_Missense_Mutation_p.E539K|APLP1_uc002ocg.2_Missense_Mutation_p.E442K|APLP1_uc010xta.1_Missense_Mutation_p.E532K	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	538	Extracellular (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCTGAGAAAGAGAAGATGAA	0.338													5	32					0	0	0.00116845	0	0
C19orf33	64073	broad.mit.edu	37	19	38795318	38795318	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:38795318G>A	uc002ohu.1	+	3	291	c.193G>A	c.(193-195)GAT>AAT	p.D65N	YIF1B_uc002ohw.2_3'UTR|YIF1B_uc002ohx.2_3'UTR|YIF1B_uc010xtx.1_3'UTR|YIF1B_uc010xty.1_3'UTR|YIF1B_uc002oia.2_3'UTR|YIF1B_uc002ohy.2_3'UTR|YIF1B_uc002ohz.2_3'UTR|C19orf33_uc002ohv.1_Silent_p.R84R	NM_033520	NP_277055	Q9GZP8	IMUP_HUMAN	HAI-2 related small protein	65						nucleus					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TTCGGACACGGATGTGAAGGT	0.692													11	24					0	0	0.000219431	0	0
FCGBP	8857	broad.mit.edu	37	19	40411937	40411937	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:40411937G>A	uc002omp.3	-	7	3699	c.3691C>T	c.(3691-3693)CCG>TCG	p.P1231S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1231	Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTCGTGCGGTCCGCAGCTG	0.672													14	27					0	0	0.000422831	0	0
FCGBP	8857	broad.mit.edu	37	19	40433468	40433468	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:40433468G>A	uc002omp.3	-	2	809	c.801C>T	c.(799-801)TTC>TTT	p.F267F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	267	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCCACAACGAAGGCCAAAT	0.597													12	14					0	0	0.000151284	0	0
LIPE	3991	broad.mit.edu	37	19	42931222	42931223	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:42931222_42931223GG>AA	uc002otr.2	-	1	356_357	c.79_80CC>TT	c.(79-81)CCT>TTT	p.P27F	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	27					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TTCTGGCCCAGGCTCTAGCGGG	0.535													29	38					0	0	6.4e-05	0	0
PSG5	5673	broad.mit.edu	37	19	43688966	43688966	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:43688966C>T	uc002ovu.2	-	2	529	c.398G>A	c.(397-399)GGA>GAA	p.G133E	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.G61E|PSG5_uc002ovx.2_Missense_Mutation_p.G133E|PSG5_uc002ovv.2_Missense_Mutation_p.G133E|PSG5_uc002ovw.2_Missense_Mutation_p.G133E	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	133	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				TCCAGTTACTCCTCTAGTCCT	0.473													44	148					0	0	0.000781405	0	0
PSG9	5678	broad.mit.edu	37	19	43762487	43762487	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:43762487C>T	uc002owd.3	-	5	1209	c.1110G>A	c.(1108-1110)GGG>GGA	p.G370G	PSG9_uc002owe.3_Silent_p.G277G|PSG9_uc010xwm.1_Silent_p.G277G|PSG9_uc002owf.3_Silent_p.G184G|PSG9_uc002owg.2_Silent_p.G277G|PSG9_uc002owh.2_Silent_p.G184G	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	370	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GCTGAAACTTCCCATTAATTG	0.443													91	128					0	0	0.000781405	0	0
ZNF428	126299	broad.mit.edu	37	19	44111830	44111830	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:44111830G>A	uc002oxa.2	-	3	941	c.506C>T	c.(505-507)TCC>TTC	p.S169F	SRRM5_uc002oxb.2_Intron	NM_182498	NP_872304	Q96B54	ZN428_HUMAN	zinc finger protein 428	169	C2H2-type.					intracellular	zinc ion binding				0		Prostate(69;0.0153)				GTTGTCGAAGGAATCCTCACA	0.557													4	16					0	0	0.000602214	0	0
CBLC	23624	broad.mit.edu	37	19	45284596	45284596	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:45284596C>T	uc002ozs.2	+	3	696	c.633C>T	c.(631-633)TTC>TTT	p.F211F	CBLC_uc010ejt.2_Silent_p.F211F	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	211	EF-hand-like.|Cbl-PTB.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TCTTCGAGTTCGACGTCTTCA	0.433			M		AML								66	238					0	0	0.000781405	0	0
GYS1	2997	broad.mit.edu	37	19	49473833	49473833	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:49473833G>A	uc002plp.2	-	14	2020	c.1779C>T	c.(1777-1779)TCC>TCT	p.S593S	GYS1_uc010xzy.1_Silent_p.S226S|GYS1_uc010emm.2_Silent_p.S529S|GYS1_uc010xzz.1_Silent_p.S513S	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	593					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CCAGAAGGTCGGAGAGGCGCT	0.597											OREG0025611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	17					0	0	0.000602214	0	0
BCL2L12	83596	broad.mit.edu	37	19	50169131	50169131	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:50169131C>T	uc002ppa.2	+	1	733	c.51C>T	c.(49-51)TTC>TTT	p.F17F	IRF3_uc002pot.1_5'Flank|IRF3_uc010end.1_5'Flank|IRF3_uc002pox.1_5'Flank|IRF3_uc002poy.1_5'Flank|IRF3_uc002pou.2_5'UTR|IRF3_uc002pov.2_5'UTR|IRF3_uc002pow.2_5'UTR|IRF3_uc002poz.1_5'Flank|IRF3_uc010ene.1_5'Flank|BCL2L12_uc002ppb.2_Silent_p.F17F	NM_138639	NP_619580	Q9HB09	B2L12_HUMAN	BCL2-like 12 isoform 1	17					apoptosis					central_nervous_system(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		TTTTGGGTTTCCGGCCAGAGG	0.572													17	48					0	0	0.000958276	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50464043	50464043	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:50464043C>T	uc010ybh.1	-	2	317	c.226G>A	c.(226-228)GGA>AGA	p.G76R	SIGLEC11_uc010ybi.1_Missense_Mutation_p.G76R	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	76	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CTGGTCCGTCCTTTGAACCAG	0.607													12	24					0	0	0.00136819	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986421	51986421	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:51986421A>G	uc002pwv.1	+	5	1007	c.1007A>G	c.(1006-1008)AAC>AGC	p.N336S		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	336	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TCCCTCCTGAACTTCTCAGAT	0.517													26	84					0	0	0.00047179	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52002861	52002861	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:52002861C>T	uc002pwx.1	-	3	974	c.918G>A	c.(916-918)ACG>ACA	p.T306T	SIGLEC12_uc002pww.1_Silent_p.T188T|SIGLEC12_uc010eoy.1_Silent_p.T33T	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	306	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCCAGGTGATCGTGGGGGGCG	0.667													18	26					0	0	0.000958276	0	0
NLRP12	91662	broad.mit.edu	37	19	54314203	54314204	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:54314203_54314204CC>AT	uc002qch.3	-	3	929_930	c.709_710GG>AT	c.(709-711)GGG>ATG	p.G237M	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.G237M|NLRP12_uc002qcj.3_Missense_Mutation_p.G237M|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.G237M	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	237	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GAAGAGCTTCCCGTCCGCCCAG	0.584													12	28					0	0	6.4e-05	0	0
PRKCG	5582	broad.mit.edu	37	19	54403571	54403571	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:54403571C>T	uc002qcq.1	+	12	1648	c.1366C>T	c.(1366-1368)CAT>TAT	p.H456Y	PRKCG_uc010yeg.1_Missense_Mutation_p.H456Y|PRKCG_uc010yeh.1_Missense_Mutation_p.H343Y	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	456	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TAAGGAGCCCCATGCAGCGTG	0.592													8	22					0	0	0.000157383	0	0
LILRB5	10990	broad.mit.edu	37	19	54759989	54759989	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:54759989C>T	uc002qex.2	-	4	683	c.572G>A	c.(571-573)TGG>TAG	p.W191*	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Nonsense_Mutation_p.W182*|LILRB5_uc002qey.2_Nonsense_Mutation_p.W191*|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_Intron|LILRB5_uc010yes.1_Intron	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	191	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTGAACCTCCACCTGCAGCT	0.567													26	25					0	0	0.000720815	0	0
LILRA2	11027	broad.mit.edu	37	19	55085818	55085818	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:55085818C>T	uc002qgg.3	+	3	210	c.121C>T	c.(121-123)CAG>TAG	p.Q41*	LILRA2_uc010ern.2_Nonsense_Mutation_p.Q41*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.Q41*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.Q41*|LILRA2_uc010yff.1_Nonsense_Mutation_p.Q29*|LILRA2_uc010ero.2_Nonsense_Mutation_p.Q29*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.Q41*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	41	Extracellular (Potential).|Ig-like C2-type 1.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TGTGATCATCCAGGGAAGTCC	0.537													22	38					0	0	0.00047179	0	0
LILRB1	10859	broad.mit.edu	37	19	55143633	55143633	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:55143633G>A	uc002qgj.2	+	6	946	c.606G>A	c.(604-606)TCG>TCA	p.S202S	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.S202S|LILRB1_uc002qgk.2_Silent_p.S202S|LILRB1_uc002qgm.2_Silent_p.S202S|LILRB1_uc010erq.2_Silent_p.S202S|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	202	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CTTATGACTCGAACTCTCCCT	0.602										HNSCC(37;0.09)			17	61					0	0	0.00121646	0	0
ZNF835	90485	broad.mit.edu	37	19	57175219	57175219	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:57175219C>T	uc010ygo.1	-	2	1414	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K	ZNF835_uc010ygn.1_Missense_Mutation_p.E450K	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TTGCCGCACTCGGGGCAGGTG	0.677													8	26					0	0	0.000274275	0	0
ZNF417	147687	broad.mit.edu	37	19	58420358	58420358	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr19:58420358G>A	uc002qqq.2	-	3	1487	c.1288C>T	c.(1288-1290)CAC>TAC	p.H430Y	ZNF417_uc010yhm.1_Missense_Mutation_p.H387Y|ZNF417_uc002qqr.2_Missense_Mutation_p.H429Y	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	430	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TCCCCAGTGTGAAGTCTCTGG	0.448													14	33					0	0	0.000566183	0	0
TPO	7173	broad.mit.edu	37	2	1497795	1497795	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:1497795C>T	uc002qww.2	+	11	2081	c.1990C>T	c.(1990-1992)CTG>TTG	p.L664L	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Silent_p.L607L|TPO_uc002qwr.2_Silent_p.L664L|TPO_uc002qwx.2_Silent_p.L607L|TPO_uc010yio.1_Silent_p.L491L|TPO_uc010yip.1_Silent_p.L664L|TPO_uc002qwy.1_Silent_p.L4L|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	664	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GATGAAGGCTCTGCGGGACGG	0.507													10	30					0	0	0.00136819	0	0
C2orf71	388939	broad.mit.edu	37	2	29294562	29294562	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:29294562C>T	uc002rmt.1	-	1	2566	c.2566G>A	c.(2566-2568)GAG>AAG	p.E856K		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	856					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GGGGAGTTCTCTGTGGACTTG	0.602													33	52					0	0	0.000491102	0	0
LOC728819	728819	broad.mit.edu	37	2	43902632	43902632	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:43902632C>T	uc010fav.1	-	1	830	c.830G>A	c.(829-831)GGA>GAA	p.G277E	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.1_Intron	NM_001101330	NP_001094800			C1GALT1-specific chaperone 1-like												0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GGGGGTCAGTCCATTGAAAGT	0.433													105	357					0	0	0.000781405	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809178	48809178	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:48809178C>T	uc010yol.1	+	1	1453	c.1406C>T	c.(1405-1407)TCC>TTC	p.S469F	STON1_uc002rwo.3_Missense_Mutation_p.S469F|STON1_uc010fbm.2_Missense_Mutation_p.S469F|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.S469F|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.S469F	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	469					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CGAGATGAATCCTATTATGAG	0.368													46	55					0	0	0.000781405	0	0
VPS54	51542	broad.mit.edu	37	2	64147595	64147595	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:64147595C>T	uc002scq.2	-	14	2199	c.2036G>A	c.(2035-2037)AGA>AAA	p.R679K	VPS54_uc002scp.2_Missense_Mutation_p.R667K|VPS54_uc002scn.2_5'Flank|VPS54_uc002sco.2_Missense_Mutation_p.R164K|VPS54_uc010fct.2_Missense_Mutation_p.R526K	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	679				EER -> VGG (in Ref. 1; AAF37319).	protein transport|retrograde transport, endosome to Golgi						0						CTTGGTTTTTCTCTCTTCATG	0.348													23	36					0	0	0.000586117	0	0
C2orf3	6936	broad.mit.edu	37	2	75929487	75929487	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:75929487G>A	uc002sno.2	-	3	587	c.457C>T	c.(457-459)CAA>TAA	p.Q153*	C2orf3_uc010ffs.2_5'Flank|C2orf3_uc002snn.2_5'UTR|C2orf3_uc010fft.2_5'UTR|C2orf3_uc002snp.3_Nonsense_Mutation_p.Q153*	NM_003203	NP_003194	P16383	GCF_HUMAN	hypothetical protein LOC6936	153					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						TAGTCATCTTGGGCCCTGGCC	0.458													28	37					0	0	0.000878237	0	0
SFTPB	6439	broad.mit.edu	37	2	85892775	85892775	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:85892775G>A	uc002sqh.2	-	5	542	c.536C>T	c.(535-537)CCT>CTT	p.P179L	SFTPB_uc002sqi.2_Missense_Mutation_p.P191L|SFTPB_uc002sqj.2_Missense_Mutation_p.P179L	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	179					organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						GGGCAGCACAGGGAGGACGAG	0.677													23	39					0	0	0.00106085	0	0
Unknown	0	broad.mit.edu	37	2	90139107	90139107	+	RNA	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:90139107G>A	uc010fhm.2	+	17		c.2019G>A								Parts of antibodies, mostly variable regions.																		GACACAGCATGGACATGAGGG	0.537													19	137					0	0	0.00152264	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95514946	95514946	+	RNA	SNP	C	T	T	rs143937878	by1000genomes	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:95514946C>T	uc010fhp.2	-	4		c.505G>A				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						ACTACTGTACCGTCTCAGCCT	0.308													6	186					0	0	0.000442599	0	0
IL1F5	26525	broad.mit.edu	37	2	113819753	113819753	+	Silent	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:113819753C>A	uc002tis.2	+	4	301	c.168C>A	c.(166-168)CCC>CCA	p.P56P	IL1F5_uc002tit.2_Silent_p.P56P	NM_173170	NP_775262	Q9UBH0	I36RA_HUMAN	interleukin 1 family, member 5	56						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						GCCTGTCCCCCGTCATCCTGG	0.617													5	45					0.00116845	0.00641743	0.00116845	1	0
MARCO	8685	broad.mit.edu	37	2	119729107	119729107	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:119729107C>T	uc002tln.1	+	4	589	c.457C>T	c.(457-459)CCA>TCA	p.P153S	MARCO_uc010yyf.1_Missense_Mutation_p.P75S	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	153	Collagen-like.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ACAAGGCGCCCCAGGTAGGTT	0.582													15	59					0	0	0.000958276	0	0
PTPN4	5775	broad.mit.edu	37	2	120702673	120702673	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:120702673G>A	uc002tmf.1	+	16	2143	c.1372G>A	c.(1372-1374)GGA>AGA	p.G458R	PTPN4_uc010flj.1_Missense_Mutation_p.G171R|PTPN4_uc010yyr.1_Missense_Mutation_p.G91R	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	458						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGAGACCCCTGGAGATGGGAA	0.373													12	55					0	0	0.000151284	0	0
PTPN4	5775	broad.mit.edu	37	2	120702675	120702675	+	Silent	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:120702675A>G	uc002tmf.1	+	16	2145	c.1374A>G	c.(1372-1374)GGA>GGG	p.G458G	PTPN4_uc010flj.1_Silent_p.G171G|PTPN4_uc010yyr.1_Silent_p.G91G	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	458						cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	AGACCCCTGGAGATGGGAAGC	0.363													13	55					0	0	0.000219431	0	0
ERCC3	2071	broad.mit.edu	37	2	128029016	128029016	+	Missense_Mutation	SNP	G	A	A	rs139049289		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:128029016G>A	uc002toh.1	-	12	1936	c.1841C>T	c.(1840-1842)TCG>TTG	p.S614L	ERCC3_uc002toe.1_Missense_Mutation_p.S369L|ERCC3_uc002tof.1_Missense_Mutation_p.S550L|ERCC3_uc002tog.1_Missense_Mutation_p.S550L	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	614	Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CAGATCAAACGAAGTGTCACC	0.423			Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				38	53					0	0	0.000374591	0	0
ZRANB3	84083	broad.mit.edu	37	2	135982014	135982014	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:135982014C>T	uc002tum.2	-	15	2349	c.2232G>A	c.(2230-2232)CGG>CGA	p.R744R	ZRANB3_uc002tuk.2_Silent_p.R287R|ZRANB3_uc002tul.2_Silent_p.R742R	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	744						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		AGATGTGAATCCGGTCAGTAT	0.358													14	38					0	0	0.000422831	0	0
THSD7B	80731	broad.mit.edu	37	2	137928475	137928475	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:137928475C>T	uc002tva.1	+	6	1597	c.1597C>T	c.(1597-1599)CGT>TGT	p.R533C	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.R423C	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGGGACATCGTATTCTGAA	0.502													7	24					0	0	0.000157383	0	0
ACVR2A	92	broad.mit.edu	37	2	148657386	148657386	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:148657386A>T	uc002twg.2	+	5	716	c.447A>T	c.(445-447)TTA>TTT	p.L149F	ACVR2A_uc010zbn.1_Missense_Mutation_p.L41F|ACVR2A_uc002twh.2_Missense_Mutation_p.L149F	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	149	Helical; (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		CACTTATGTTAATTGCGGGGA	0.443													71	115					0	0	0.000781405	0	0
ACVR2A	92	broad.mit.edu	37	2	148657389	148657389	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:148657389T>G	uc002twg.2	+	5	719	c.450T>G	c.(448-450)ATT>ATG	p.I150M	ACVR2A_uc010zbn.1_Missense_Mutation_p.I42M|ACVR2A_uc002twh.2_Missense_Mutation_p.I150M	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	150	Helical; (Potential).				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		TTATGTTAATTGCGGGGATTG	0.438													69	106					0	0	0.000781405	0	0
MBD5	55777	broad.mit.edu	37	2	149247024	149247024	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:149247024C>T	uc002twm.3	+	12	4112	c.3124C>T	c.(3124-3126)CCT>TCT	p.P1042S	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.P1042S|MBD5_uc002two.2_Missense_Mutation_p.P300S|MBD5_uc002twp.2_Missense_Mutation_p.P92S	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1042						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CACAGCACTTCCTGAGAATCC	0.468													6	33					0	0	0.00116845	0	0
MBD5	55777	broad.mit.edu	37	2	149247862	149247862	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:149247862C>T	uc002twm.3	+	12	4950	c.3962C>T	c.(3961-3963)TCC>TTC	p.S1321F	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.S1321F|MBD5_uc002two.2_Missense_Mutation_p.S579F|MBD5_uc002twp.2_Missense_Mutation_p.S371F	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1321						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCTCCAAGTTCCTCAAATAGT	0.458													17	31					0	0	0.000422831	0	0
PLA2R1	22925	broad.mit.edu	37	2	160798644	160798644	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:160798644C>T	uc002ube.1	-	29	4378	c.4171G>A	c.(4171-4173)GAA>AAA	p.E1391K	PLA2R1_uc010zcp.1_Missense_Mutation_p.E1389K	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1391	Extracellular (Potential).				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GTACCTTTTTCTGGCAGCGCC	0.289													20	45					0	0	0.000586117	0	0
GCG	2641	broad.mit.edu	37	2	163000618	163000618	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:163000618G>A	uc002ucc.2	-	5	554	c.455C>T	c.(454-456)TCT>TTT	p.S152F		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	152					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	CATCTCATCAGAGAAAGAACC	0.393													18	74					0	0	0.00121646	0	0
SCN9A	6335	broad.mit.edu	37	2	167108350	167108351	+	Missense_Mutation	DNP	GG	TA	TA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:167108350_167108351GG>TA	uc010fpl.2	-	18	3704_3705	c.3363_3364CC>TA	c.(3361-3366)AACCCT>AATACT	p.P1122T	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1133						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CCAGGCAAAGGGTTATCAACTG	0.45													16	19					0	0	6.4e-05	0	0
DHRS9	10170	broad.mit.edu	37	2	169938402	169938402	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:169938402A>T	uc002uep.2	+	5	1815	c.311A>T	c.(310-312)AAA>ATA	p.K104I	DHRS9_uc002ueq.2_Missense_Mutation_p.K104I|DHRS9_uc010zdc.1_Missense_Mutation_p.K164I|DHRS9_uc002uer.1_Missense_Mutation_p.K104I|DHRS9_uc010zdd.1_Missense_Mutation_p.K104I|DHRS9_uc010zde.1_Missense_Mutation_p.K104I	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	104					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						GTTGGGGAGAAAGGTGAGAGA	0.488													10	14					0	0	0.000978159	0	0
TTN	7273	broad.mit.edu	37	2	179422801	179422801	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:179422801C>T	uc010zfg.1	-	277	79800	c.79576G>A	c.(79576-79578)GAA>AAA	p.E26526K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E20221K|TTN_uc010zfi.1_Missense_Mutation_p.E20154K|TTN_uc010zfj.1_Missense_Mutation_p.E20029K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27453							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGTAATTTCGGTATTAAAT	0.428													19	94					0	0	0.00152264	0	0
CCDC141	285025	broad.mit.edu	37	2	179730571	179730571	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:179730571G>A	uc002unf.1	-	7	979	c.922C>T	c.(922-924)CGT>TGT	p.R308C		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	308	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GCTTTGGCACGCCACTTCATG	0.527													55	206					0	0	0.000781405	0	0
ZNF385B	151126	broad.mit.edu	37	2	180311347	180311347	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:180311347A>G	uc002unn.3	-	7	1425	c.821T>C	c.(820-822)GTT>GCT	p.V274A	ZNF385B_uc002unj.2_Missense_Mutation_p.V172A|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Missense_Mutation_p.V171A|ZNF385B_uc002unm.2_Missense_Mutation_p.V198A	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	274						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TTCTGATTCAACAACAGTACC	0.473													38	53					0	0	0.00111076	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187693433	187693433	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:187693433T>G	uc002upu.1	-	9	1220	c.1180A>C	c.(1180-1182)ACT>CCT	p.T394P		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	394					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTTTTCCAAGTTAAAGGGTTA	0.348													16	19					0	0	0.000422831	0	0
Unknown	0	broad.mit.edu	37	2	190788357	190788357	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:190788357G>A	uc002uro.2	+	1	439	c.296G>A	c.(295-297)CGA>CAA	p.R99Q						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;																		GGTGTGAAACGATCTGCAGCG	0.483													14	38					0	0	0.000422831	0	0
NAB1	4664	broad.mit.edu	37	2	191523930	191523930	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:191523930G>C	uc002usb.2	+	4	600	c.28G>C	c.(28-30)GGG>CGG	p.G10R	NAB1_uc010fsc.2_Missense_Mutation_p.G10R|NAB1_uc010fsd.2_Missense_Mutation_p.G10R|NAB1_uc002usc.2_Missense_Mutation_p.G10R|NAB1_uc010zgh.1_Missense_Mutation_p.G10R	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	10	NCD1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CAGGACCCTGGGGGAGTTGCA	0.403													3	51					0	0	6.4e-05	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174680	207174680	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:207174680G>A	uc002vbp.2	+	5	5678	c.5428G>A	c.(5428-5430)GAT>AAT	p.D1810N		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1810							nucleic acid binding|zinc ion binding			ovary(3)	3						TGTCATAGAGGATAATCCTGA	0.393													34	54					0	0	0.00058488	0	0
LOC200726	200726	broad.mit.edu	37	2	207509006	207509006	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:207509006T>C	uc010fuh.1	+	2	221	c.46T>C	c.(46-48)TTC>CTC	p.F16L		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		CCCCTTGAGCTTCACCTGCTC	0.527													7	15					0	0	0.000157383	0	0
ABCA12	26154	broad.mit.edu	37	2	215910714	215910714	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:215910714T>A	uc002vew.2	-	7	939	c.719A>T	c.(718-720)AAG>ATG	p.K240M	ABCA12_uc010zjn.1_Translation_Start_Site	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	240					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAACACTATCTTCTGATTGTT	0.363													13	43					0	0	0.000219431	0	0
RUFY4	285180	broad.mit.edu	37	2	218947953	218947953	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:218947953G>A	uc002vgw.2	+	12	2801	c.957G>A	c.(955-957)ATG>ATA	p.M319I	RUFY4_uc002vgy.1_RNA|RUFY4_uc010fvl.1_Missense_Mutation_p.M319I	NM_198483	NP_940885	Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	492	FYVE-type.						metal ion binding			pancreas(1)	1		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TCCAGGCCATGAAGAGGCGGG	0.597													30	32					0	0	0.00170553	0	0
C2orf24	27013	broad.mit.edu	37	2	220038173	220038173	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:220038173C>T	uc002vju.3	-	7	741	c.589G>A	c.(589-591)GGA>AGA	p.G197R	C2orf24_uc002vjv.2_Missense_Mutation_p.G197R	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	197					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGCCACCGTCCCTGCTGCTCA	0.617													16	24					0	0	0.000308642	0	0
TRIP12	9320	broad.mit.edu	37	2	230655878	230655878	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:230655878G>A	uc002vpw.1	-	29	4389	c.4280C>T	c.(4279-4281)TCC>TTC	p.S1427F	TRIP12_uc002vpx.1_Missense_Mutation_p.S1475F|TRIP12_uc002vpy.1_Missense_Mutation_p.S1157F	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1427					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ATTTCTAGGGGAAGTTTTCGT	0.398													40	73					0	0	0.000589545	0	0
INPP5D	3635	broad.mit.edu	37	2	234102595	234102595	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:234102595G>A	uc010zmo.1	+	22	2737	c.2584G>A	c.(2584-2586)GAG>AAG	p.E862K	INPP5D_uc010zmp.1_Missense_Mutation_p.E861K	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	862					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CAAGACGAGGGAGAAGCTCTA	0.592													7	15					0	0	0.000157383	0	0
IQCA1	79781	broad.mit.edu	37	2	237233337	237233337	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr2:237233337C>T	uc002vvz.1	-	19	2645	c.2463G>A	c.(2461-2463)AGG>AGA	p.R821R	IQCA1_uc002vwb.2_Silent_p.R829R|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Silent_p.R780R	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	821							ATP binding			ovary(1)	1						tcttttatttccttttccctt	0.333													4	15					0	0	0.00024832	0	0
C20orf54	113278	broad.mit.edu	37	20	742387	742387	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:742387G>A	uc002wed.3	-	4	1494	c.1155C>T	c.(1153-1155)CCC>CCT	p.P385P	C20orf54_uc002wee.2_Silent_p.P385P	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	385	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						AGAGGGGGCAGGGGCTCATCA	0.647													7	13					0	0	8.12818e-05	0	0
SIRPB2	284759	broad.mit.edu	37	20	1460549	1460549	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:1460549C>T	uc002wfg.2	-	2	475	c.247G>A	c.(247-249)GAA>AAA	p.E83K	SIRPB2_uc002wfh.3_Intron|SIRPB2_uc010zpr.1_Intron	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	83	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane					0						TTATAAATTTCCTGTTGGTCC	0.463													24	56					0	0	0.000375601	0	0
PLCB4	5332	broad.mit.edu	37	20	9288477	9288477	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:9288477G>A	uc002wnf.2	+	3	152	c.16G>A	c.(16-18)GAA>AAA	p.E6K	PLCB4_uc010gbw.1_Missense_Mutation_p.E6K|PLCB4_uc010gbx.2_Missense_Mutation_p.E6K|PLCB4_uc002wne.2_Missense_Mutation_p.E6K	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	6					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						CAAACCTTATGAATTTAACTG	0.333													10	31					0	0	0.000978159	0	0
ANKRD5	63926	broad.mit.edu	37	20	10030179	10030179	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:10030179C>T	uc002wno.2	+	7	1355	c.962C>T	c.(961-963)CCA>CTA	p.P321L	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.P321L|ANKRD5_uc010gbz.2_Missense_Mutation_p.P132L	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	321							calcium ion binding			ovary(1)|breast(1)	2						GCCAAAAATCCAAATCCACTG	0.527													36	40					0	0	0.00058488	0	0
FLRT3	23767	broad.mit.edu	37	20	14306629	14306629	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:14306629G>A	uc002wov.1	-	3	1991	c.1524C>T	c.(1522-1524)AAC>AAT	p.N508N	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Silent_p.N508N	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	508	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TGGTTGTAGGGTTGTACATTC	0.458													42	70					0	0	0.000509022	0	0
SLC24A3	57419	broad.mit.edu	37	20	19665880	19665880	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:19665880G>A	uc002wrl.2	+	12	1396	c.1199G>A	c.(1198-1200)AGG>AAG	p.R400K		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	400	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						GGGACACGGAGGGACGATGTT	0.398													12	44					0	0	0.000978159	0	0
RIN2	54453	broad.mit.edu	37	20	19955746	19955747	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:19955746_19955747CC>TT	uc002wro.1	+	7	1113_1114	c.1077_1078CC>TT	c.(1075-1080)CCCCGG>CCTTGG	p.R360W	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Missense_Mutation_p.R154W	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	360					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCCCTCCACCCCGGCTGAAGAA	0.609													12	38					0	0	6.4e-05	0	0
C20orf26	26074	broad.mit.edu	37	20	20056175	20056175	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:20056175C>T	uc002wru.2	+	6	558	c.482C>T	c.(481-483)CCG>CTG	p.P161L	C20orf26_uc010gcw.1_Missense_Mutation_p.P115L|C20orf26_uc010zse.1_Missense_Mutation_p.P161L|C20orf26_uc010zsf.1_Missense_Mutation_p.P161L	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	161										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GGGAACATCCCGTGTCTGACG	0.428													60	115					0	0	0.000781405	0	0
XRN2	22803	broad.mit.edu	37	20	21349172	21349172	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:21349172G>C	uc002wsf.1	+	27	2623	c.2528G>C	c.(2527-2529)GGA>GCA	p.G843A	XRN2_uc002wsg.1_Missense_Mutation_p.G767A|XRN2_uc010zsk.1_Missense_Mutation_p.G789A	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	843					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						ACTTACCAGGGAAACTTATAC	0.393													41	113					0	0	0.000509022	0	0
ZNF337	26152	broad.mit.edu	37	20	25656459	25656459	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:25656459C>T	uc002wva.2	-	4	1987	c.1465G>A	c.(1465-1467)GGA>AGA	p.G489R	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Missense_Mutation_p.G457R|ZNF337_uc002wvb.2_Missense_Mutation_p.G489R|ZNF337_uc002wvc.2_Missense_Mutation_p.G489R	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	489	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCCGACATCCATAAGGCTTC	0.498													35	105					0	0	0.000491102	0	0
DEFB115	245929	broad.mit.edu	37	20	29847269	29847269	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:29847269G>A	uc002wvp.1	+	2	101	c.101G>A	c.(100-102)TGG>TAG	p.W34*		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	34					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			ATAGATGGATGGATCAGAAGG	0.313													11	56					0	0	0.000151284	0	0
DEFB119	245932	broad.mit.edu	37	20	29965143	29965143	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:29965143G>A	uc002wvt.2	-	2	281	c.161C>T	c.(160-162)TCC>TTC	p.S54F	DEFB119_uc002wvs.2_3'UTR	NM_153289	NP_695021	Q8N690	DB119_HUMAN	defensin, beta 119 isoform a precursor	54					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GAGGCAGCAGGACTGACAATT	0.483													118	99					0	0	0.000781405	0	0
TPX2	22974	broad.mit.edu	37	20	30385293	30385293	+	Silent	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:30385293C>A	uc002wwp.1	+	16	2618	c.1920C>A	c.(1918-1920)CCC>CCA	p.P640P	TPX2_uc010gdv.1_Silent_p.P676P	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	640					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			CCTTTGTTCCCAAGAAAGAGA	0.458													10	233					0.000978159	0.00538896	0.000978159	1	0
PIGU	128869	broad.mit.edu	37	20	33162970	33162970	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:33162970A>G	uc002xas.2	-	11	1332	c.1132T>C	c.(1132-1134)TAT>CAT	p.Y378H	PIGU_uc010zul.1_Missense_Mutation_p.Y378H|PIGU_uc002xat.2_Missense_Mutation_p.Y358H	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	378					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane					0						CTTCCTGCATAAATCCAGAGG	0.507													33	68					0	0	0.000339439	0	0
MYH7B	57644	broad.mit.edu	37	20	33586421	33586421	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:33586421G>A	uc002xbi.1	+	32	4200	c.4108G>A	c.(4108-4110)GAG>AAG	p.E1370K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1328	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCAGCTAGAGGAGGAAAGCAA	0.632													10	41					0	0	0.000673444	0	0
BPI	671	broad.mit.edu	37	20	36954768	36954768	+	Silent	SNP	C	T	T	rs144501421		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:36954768C>T	uc002xib.2	+	10	1169	c.1107C>T	c.(1105-1107)GCC>GCT	p.A369A		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	369					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				TCTACCCTGCCGTGGATGTCC	0.542													8	24					0	0	0.000157383	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356631	37356631	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:37356631C>T	uc002xjc.2	+	2	1190	c.927C>T	c.(925-927)TCC>TCT	p.S309S		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	309	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TCCCCATCTCCATTGGCATCA	0.537													18	45					0	0	0.00121646	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44506200	44506200	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:44506200C>T	uc002xqd.2	+	2	1206	c.1003C>T	c.(1003-1005)CTG>TTG	p.L335L	ZSWIM3_uc010zxg.1_Silent_p.L329L	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	335							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				GAAGGAAGCCCTGCGGGAGGC	0.517													32	112					0	0	0.000692331	0	0
SLC13A3	64849	broad.mit.edu	37	20	45242182	45242182	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:45242182G>A	uc002xsf.1	-	2	332	c.294C>T	c.(292-294)ATC>ATT	p.I98I	SLC13A3_uc010ghn.1_Silent_p.I67I|SLC13A3_uc010zxw.1_Silent_p.I98I|SLC13A3_uc002xsg.1_Silent_p.I51I|SLC13A3_uc010gho.1_Silent_p.I51I|SLC13A3_uc010zxx.1_5'UTR|SLC13A3_uc002xsi.3_Silent_p.I51I	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	98	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CGCTGGCCATGATCAGCCCAC	0.577													8	28					0	0	0.000157383	0	0
ZMYND8	23613	broad.mit.edu	37	20	45927622	45927622	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:45927622G>A	uc002xta.1	-	4	498	c.244C>T	c.(244-246)CCG>TCG	p.P82S	ZMYND8_uc010ghr.1_Intron|ZMYND8_uc002xst.1_Intron|ZMYND8_uc002xsu.1_Missense_Mutation_p.P82S|ZMYND8_uc002xsv.1_Intron|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Intron|ZMYND8_uc002xsz.1_Intron|ZMYND8_uc010zxy.1_Missense_Mutation_p.P109S|ZMYND8_uc002xtb.1_Missense_Mutation_p.P102S|ZMYND8_uc002xss.2_Intron|ZMYND8_uc010zxz.1_Intron|ZMYND8_uc002xtc.1_Missense_Mutation_p.P102S|ZMYND8_uc002xtd.1_Intron|ZMYND8_uc002xte.1_Missense_Mutation_p.P82S|ZMYND8_uc010zya.1_Missense_Mutation_p.P82S|ZMYND8_uc002xtf.1_Missense_Mutation_p.P102S|ZMYND8_uc002xtg.2_Intron|ZMYND8_uc010ghs.1_Intron|ZMYND8_uc002xth.2_Missense_Mutation_p.P102S	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	82							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CCATCCTGCGGTACAACATCA	0.483													46	103					0	0	0.000781405	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47558509	47558509	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:47558509C>T	uc002xtx.3	+	3	413	c.261C>T	c.(259-261)TCC>TCT	p.S87S		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	87					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCAGCACATCCCTTGACTGCT	0.502													16	51					0	0	0.000422831	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871441	51871441	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:51871441G>A	uc002xwo.2	+	2	2400	c.1444G>A	c.(1444-1446)GAG>AAG	p.E482K		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	482					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CGTGAAAAGCGAGGACTATGA	0.428													38	97					0	0	0.00111076	0	0
ZNF831	128611	broad.mit.edu	37	20	57766753	57766753	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:57766753G>A	uc002yan.2	+	1	679	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	227						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CCCCAGACCAGAGGGCAGGGG	0.692													15	43					0	0	0.000308642	0	0
C20orf200	253868	broad.mit.edu	37	20	61143756	61143756	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr20:61143756G>A	uc002ycz.1	-	3	583	c.92C>T	c.(91-93)TCG>TTG	p.S31L	C20orf200_uc002ycy.2_RNA	NM_152757	NP_689970			hypothetical protein LOC253868												0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			CTTGGCTTCCGAGAAACCGCT	0.667													26	76					0	0	0.00047179	0	0
TPTE	7179	broad.mit.edu	37	21	10952951	10952951	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr21:10952951C>T	uc002yip.1	-	9	614	c.246G>A	c.(244-246)AAG>AAA	p.K82K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.K64K|TPTE_uc002yir.1_Silent_p.K44K|TPTE_uc010gkv.1_5'UTR	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	82					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCACAATTTTCTTAATCTTGC	0.249													10	61					0	0	0.00136819	0	0
GRIK1	2897	broad.mit.edu	37	21	30959753	30959753	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr21:30959753G>A	uc002yno.1	-	12	2190	c.1726C>T	c.(1726-1728)CCA>TCA	p.P576S	GRIK1_uc002ynn.2_Missense_Mutation_p.P561S|GRIK1_uc011acs.1_Missense_Mutation_p.P576S|GRIK1_uc011act.1_Missense_Mutation_p.P437S|GRIK1_uc010glq.1_Missense_Mutation_p.P419S	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	576	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CAAATATCTGGAGACAGGGGG	0.473													22	35					0	0	0.00106085	0	0
C22orf29	79680	broad.mit.edu	37	22	19838874	19838874	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:19838874G>A	uc002zqg.2	-	2	1510	c.911C>T	c.(910-912)TCG>TTG	p.S304L	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.S304L|C22orf29_uc002zqi.2_Missense_Mutation_p.S304L|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	304	Pro-rich.										0	Colorectal(54;0.0993)					AGCTGACTCCGACAGTCTAGG	0.587													15	39					0	0	0.000308642	0	0
UPB1	51733	broad.mit.edu	37	22	24916425	24916425	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:24916425C>T	uc003aaf.2	+	7	983	c.862C>T	c.(862-864)CGA>TGA	p.R288*	UPB1_uc003aae.2_Nonsense_Mutation_p.R220*|UPB1_uc011ajt.1_Nonsense_Mutation_p.R288*	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	288	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					CGCCATCAATCGAGTGGGCAC	0.602													4	11					0	0	0.00024832	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688745	26688745	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:26688745C>T	uc003acb.2	+	2	624	c.468C>T	c.(466-468)CTC>CTT	p.L156L	SEZ6L_uc003acc.2_Silent_p.L156L|SEZ6L_uc011akc.1_Silent_p.L156L|SEZ6L_uc003acd.2_Silent_p.L156L|SEZ6L_uc011akd.1_Silent_p.L156L|SEZ6L_uc003ace.2_Silent_p.L156L|SEZ6L_uc003acf.1_5'UTR|SEZ6L_uc010gvc.1_5'UTR	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	156	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GCCTAGATCTCCTCTCCTCCT	0.667													12	33					0	0	0.00136819	0	0
SEZ6L	23544	broad.mit.edu	37	22	26707860	26707860	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:26707860G>A	uc003acb.2	+	8	1964	c.1808G>A	c.(1807-1809)GGC>GAC	p.G603D	SEZ6L_uc003acc.2_Missense_Mutation_p.G603D|SEZ6L_uc011akc.1_Missense_Mutation_p.G603D|SEZ6L_uc003acd.2_Missense_Mutation_p.G603D|SEZ6L_uc011akd.1_Missense_Mutation_p.G603D|SEZ6L_uc003ace.2_Missense_Mutation_p.G603D|SEZ6L_uc003acf.1_Missense_Mutation_p.G376D|SEZ6L_uc010gvc.1_Missense_Mutation_p.G376D	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	603	Sushi 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTGGAGCAGGGCCCGGCCATC	0.577													58	158					0	0	0.000781405	0	0
EIF3L	51386	broad.mit.edu	37	22	38273740	38273740	+	Silent	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:38273740C>A	uc003auf.2	+	11	1224	c.1137C>A	c.(1135-1137)CCC>CCA	p.P379P	EIF3L_uc003aue.1_Silent_p.P379P|EIF3L_uc011ann.1_Silent_p.P331P|EIF3L_uc003aug.2_Silent_p.P271P|EIF3L_uc003auh.2_Silent_p.P112P	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	379						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CGATGTACCCCATGCGTATTG	0.512													21	54					1.00905e-13	5.69128e-13	0.00121646	1	0
KDELR3	11015	broad.mit.edu	37	22	38870562	38870562	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:38870562C>T	uc003avv.2	+	2	282	c.126C>T	c.(124-126)CTC>CTT	p.L42L	KDELR3_uc003avu.2_Silent_p.L42L	NM_006855	NP_006846	O43731	ERD23_HUMAN	KDEL receptor 3 isoform a	42	Helical; (Potential).			L -> P (in Ref. 4; BAD96650).	protein retention in ER lumen|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	ER retention sequence binding|receptor activity			ovary(2)	2	Melanoma(58;0.0286)					TGTTTGCTCTCGTCTTCACCA	0.552													46	53					0	0	0.000781405	0	0
DMC1	11144	broad.mit.edu	37	22	38934573	38934573	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:38934573G>A	uc003avz.1	-	10	806	c.631C>T	c.(631-633)CAT>TAT	p.H211Y	DMC1_uc011anv.1_Missense_Mutation_p.H156Y	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	211					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					GCTTCTTCATGGAACTTTGCT	0.353								Homologous_recombination					77	211					0	0	0.000781405	0	0
NCRNA00207	388910	broad.mit.edu	37	22	44966447	44966447	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:44966447G>A	uc003bev.1	+	2	171	c.104G>A	c.(103-105)GGA>GAA	p.G35E	NCRNA00207_uc011aqg.1_RNA|NCRNA00207_uc011aqh.1_RNA	NM_001012986	NP_001013004			SubName: Full=Novel gene;												0						AACCAGAGGGGAACACCGTGC	0.507													5	5					0	0	8.12818e-05	0	0
PPARA	5465	broad.mit.edu	37	22	46614165	46614165	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:46614165C>T	uc003bgw.1	+	6	641	c.375C>T	c.(373-375)TTC>TTT	p.F125F	PPARA_uc003bgx.1_Silent_p.F125F|PPARA_uc010hab.1_Silent_p.F125F|PPARA_uc003bha.2_Silent_p.F125F|PPARA_uc003bhb.1_Silent_p.F125F|PPARA_uc010hac.1_5'UTR	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	125	Nuclear receptor.				fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	CACAGGGCTTCTTTCGGCGAA	0.448													14	12					0	0	0.000219431	0	0
SHANK3	85358	broad.mit.edu	37	22	51160649	51160649	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr22:51160649C>T	uc003bne.1	+	22	4436	c.4436C>T	c.(4435-4437)CCT>CTT	p.P1479L	SHANK3_uc003bnf.1_Missense_Mutation_p.P926L|SHANK3_uc010hbg.1_Missense_Mutation_p.P661L	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1479										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CCTGCCCGCCCTCGCTACCTC	0.682													13	12					0	0	0.000151284	0	0
VHL	7428	broad.mit.edu	37	3	10188264	10188264	+	Missense_Mutation	SNP	T	A	A	rs5030833		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:10188264T>A	uc003bvc.2	+	2	620	c.407T>A	c.(406-408)TTT>TAT	p.F136Y	VHL_uc003bvd.2_Intron	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	136	Involved in binding to CCT complex.		F -> S (in VHLD).|F -> Y (in VHLD).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.F136fs*23(5)|p.F136V(3)|p.F136fs*8(2)|p.F136C(1)|p.F136I(1)|p.F136del(1)|p.?fs(1)|p.F136L(1)|p.F136S(1)|p.L135fs*7(1)|p.F136Y(1)|p.V137fs*7(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		ACTGAATTATTTGTGCCATCT	0.428		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				37	76					0	0	0.00170553	0	0
IRAK2	3656	broad.mit.edu	37	3	10280549	10280549	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:10280549G>A	uc003bve.1	+	12	1667	c.1591G>A	c.(1591-1593)GAC>AAC	p.D531N		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	531					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						GGAAACAGACGACGTTGACAA	0.597													18	36					0	0	0.000229342	0	0
SLC6A1	6529	broad.mit.edu	37	3	11078619	11078619	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:11078619G>A	uc010hdq.2	+	16	2178	c.1767G>A	c.(1765-1767)GCG>GCA	p.A589A		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	589	Cytoplasmic (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	AGCCCCAGGCGGGCAGCTCCA	0.642													10	37					0	0	0.000151284	0	0
GLB1	2720	broad.mit.edu	37	3	33065758	33065758	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:33065758C>T	uc003cfi.1	-	11	1245	c.1128G>A	c.(1126-1128)AAG>AAA	p.K376K	GLB1_uc003cfh.1_Silent_p.K346K|GLB1_uc003cfj.1_Silent_p.K245K|GLB1_uc011axk.1_Silent_p.K424K	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	376					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				CCAAAGTGACCTTTCCATATG	0.353													7	12					0	0	0.000157383	0	0
TRANK1	9881	broad.mit.edu	37	3	36898686	36898686	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:36898686G>A	uc003cgj.2	-	3	1047	c.745C>T	c.(745-747)CTG>TTG	p.L249L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	799					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AGCTTCTTCAGCATTTCTGAA	0.512													59	120					0	0	0.000781405	0	0
SCN10A	6336	broad.mit.edu	37	3	38753871	38753871	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:38753871G>A	uc003ciq.2	-	22	3870	c.3870C>T	c.(3868-3870)ATC>ATT	p.I1290I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1290	III.|Helical; Name=S5 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGCCAGAAGATGAGGCAGA	0.527													13	39					0	0	0.000151284	0	0
SCN10A	6336	broad.mit.edu	37	3	38770173	38770173	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:38770173C>T	uc003ciq.2	-	15	2500	c.2500G>A	c.(2500-2502)GAC>AAC	p.D834N		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	834	II.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGAAGAAGTCGTGCATGTGC	0.512													14	21					0	0	0.000151284	0	0
SCN11A	11280	broad.mit.edu	37	3	38991652	38991652	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:38991652C>T	uc011ays.1	-	1	401	c.202G>A	c.(202-204)GAC>AAC	p.D68N		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	68					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CGAGGAATGTCGCCATAGAGC	0.453													22	70					0	0	0.000229342	0	0
TGM4	7047	broad.mit.edu	37	3	44943043	44943043	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:44943043C>T	uc003coc.3	+	7	758	c.685C>T	c.(685-687)CTC>TTC	p.L229F	TGM4_uc003cob.2_RNA	NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	229					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	CCAGGGCGTGCTCATTGGGAA	0.597													4	8					0	0	0.00024832	0	0
CCR3	1232	broad.mit.edu	37	3	46307563	46307563	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:46307563G>A	uc003cpg.1	+	4	1457	c.914G>A	c.(913-915)GGA>GAA	p.G305E	CCR3_uc003cpi.1_Missense_Mutation_p.G305E|CCR3_uc003cpj.1_Missense_Mutation_p.G305E|CCR3_uc003cpk.1_Missense_Mutation_p.G326E|CCR3_uc010hjb.1_Missense_Mutation_p.G323E|CCR3_uc003cpl.1_Missense_Mutation_p.G338E	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	305	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GCCTTTGTTGGAGAGAGGTTC	0.552													8	23					0	0	0.000673444	0	0
DHX30	22907	broad.mit.edu	37	3	47882444	47882444	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:47882444C>T	uc003cru.2	+	7	870	c.444C>T	c.(442-444)TCC>TCT	p.S148S	DHX30_uc003crs.2_Silent_p.S109S|DHX30_uc003crt.2_Silent_p.S109S|DHX30_uc010hjr.1_Silent_p.S176S	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	148						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GCTTTGGCTCCCCTGCCGACA	0.602													7	17					0	0	0.000157383	0	0
NISCH	11188	broad.mit.edu	37	3	52524839	52524839	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:52524839C>T	uc011beg.1	+	20	3804	c.3732C>T	c.(3730-3732)TTC>TTT	p.F1244F	NISCH_uc003ded.3_Silent_p.F1244F|NISCH_uc003dee.3_Silent_p.F733F|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1244					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		ACCAGCATTTCCGGCTGACGG	0.542													17	45					0	0	0.000295444	0	0
STAB1	23166	broad.mit.edu	37	3	52556577	52556577	+	Missense_Mutation	SNP	G	A	A	rs148752341		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:52556577G>A	uc003dej.2	+	61	6691	c.6617G>A	c.(6616-6618)CGG>CAG	p.R2206Q	STAB1_uc003dek.1_Missense_Mutation_p.R221Q|STAB1_uc003del.2_Missense_Mutation_p.R93Q	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2206	Extracellular (Potential).|Link.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCAGAGAAACGGGCTGGCGTT	0.612													13	47					0	0	0.00074312	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919610	54919610	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:54919610C>T	uc003dhf.2	+	23	2101	c.2053C>T	c.(2053-2055)CAG>TAG	p.Q685*	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Nonsense_Mutation_p.Q591*|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Nonsense_Mutation_p.Q419*|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	685	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		ACCTCTGCTCCAGTGTGAGTA	0.473													6	10					0	0	8.12818e-05	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64536712	64536712	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:64536712G>A	uc003dmg.2	-	31	4757	c.4725C>T	c.(4723-4725)TCC>TCT	p.S1575S	ADAMTS9_uc011bfo.1_Silent_p.S1547S|ADAMTS9_uc003dmh.1_Silent_p.S1404S|ADAMTS9_uc011bfp.1_Silent_p.S486S	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1575	TSP type-1 13.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TGCGGTACCTGGAGCCTTCGC	0.458													66	157					0	0	0.000781405	0	0
EPHA3	2042	broad.mit.edu	37	3	89390106	89390106	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:89390106G>A	uc003dqy.2	+	4	1080	c.855G>A	c.(853-855)ATG>ATA	p.M285I	EPHA3_uc003dqx.1_Missense_Mutation_p.M285I|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	285	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ATGGTAATATGAAGTGTGCTA	0.393										TSP Lung(6;0.00050)			22	83					0	0	0.00047179	0	0
EPHA6	285220	broad.mit.edu	37	3	96706372	96706372	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:96706372G>A	uc010how.1	+	3	692	c.649G>A	c.(649-651)GAA>AAA	p.E217K	EPHA6_uc003drp.1_Missense_Mutation_p.E217K	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	122	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GACTTGCAAAGAAACATTTAA	0.398													24	73					0	0	0.000295444	0	0
OR5H15	403274	broad.mit.edu	37	3	97888154	97888154	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:97888154G>A	uc011bgu.1	+	1	611	c.611G>A	c.(610-612)GGT>GAT	p.G204D		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATTTTCTCAGGTTCAATTCAG	0.323													7	16					0	0	0.000274275	0	0
OR5H2	79310	broad.mit.edu	37	3	98002360	98002360	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:98002360C>T	uc003dsj.1	+	1	629	c.629C>T	c.(628-630)TCA>TTA	p.S210L		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	210	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TTGTCTGGCTCAATTCAGGTA	0.318													9	40					0	0	0.000274275	0	0
GPR128	84873	broad.mit.edu	37	3	100354664	100354664	+	Silent	SNP	A	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:100354664A>C	uc003duc.2	+	5	859	c.591A>C	c.(589-591)TCA>TCC	p.S197S	GPR128_uc011bhc.1_5'UTR	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	197	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						GAAATGCTTCACCTGAGGTAA	0.368													4	20					0	0	0.00024832	0	0
HHLA2	11148	broad.mit.edu	37	3	108076967	108076967	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:108076967C>T	uc003dwy.3	+	6	1129	c.962C>T	c.(961-963)TCG>TTG	p.S321L	HHLA2_uc011bhl.1_Missense_Mutation_p.S257L|HHLA2_uc010hpu.2_Missense_Mutation_p.S321L|HHLA2_uc003dwz.2_Missense_Mutation_p.S321L	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	321	Ig-like V-type 2.					integral to membrane				ovary(1)	1						AATATTTCTTCGGATGAATAT	0.368													14	33					0	0	0.000151284	0	0
CD96	10225	broad.mit.edu	37	3	111368615	111368615	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:111368615G>A	uc003dxw.2	+	15	1890	c.1720G>A	c.(1720-1722)GAA>AAA	p.E574K	CD96_uc003dxx.2_Missense_Mutation_p.E558K|CD96_uc010hpy.1_Missense_Mutation_p.E557K	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	574	Cytoplasmic (Potential).				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						AGAGCCCAACGAAAGTGATCT	0.463									Opitz_Trigonocephaly_syndrome				13	72					0	0	0.000219431	0	0
C3orf1	51300	broad.mit.edu	37	3	119219648	119219648	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:119219648A>T	uc003ecn.2	+	2	514	c.301A>T	c.(301-303)AAA>TAA	p.K101*	C3orf1_uc003eco.2_RNA|C3orf1_uc003ecp.2_RNA	NM_016589	NP_057673	Q9NPL8	TIDC1_HUMAN	hypothetical protein LOC51300	101						integral to membrane|mitochondrial inner membrane	protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.186)		TATTCATGCTAAACAACAATA	0.433													15	31					0	0	0.00074312	0	0
CD86	942	broad.mit.edu	37	3	121774339	121774339	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:121774339G>A	uc003eet.2	+	1	119	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CD86_uc011bjo.1_5'UTR|CD86_uc011bjp.1_Missense_Mutation_p.M1I	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	1					interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CAGCCAAAATGGATCCCCAGT	0.453													13	27					0	0	0.000219431	0	0
PARP9	83666	broad.mit.edu	37	3	122259595	122259595	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:122259595C>T	uc010hri.2	-	8	1739	c.1594G>A	c.(1594-1596)GCA>ACA	p.A532T	PARP9_uc003eff.3_Missense_Mutation_p.A497T|PARP9_uc011bjs.1_Missense_Mutation_p.A497T|PARP9_uc003efg.2_Missense_Mutation_p.A77T|PARP9_uc003efi.2_Missense_Mutation_p.A497T|PARP9_uc003efh.2_Missense_Mutation_p.A532T|PARP9_uc003efj.2_Missense_Mutation_p.A497T	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	532					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TGGATCCATGCGTGGGCCTCA	0.448													26	84					0	0	0.00106085	0	0
PARP14	54625	broad.mit.edu	37	3	122437462	122437462	+	Silent	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:122437462G>C	uc003efq.3	+	14	4523	c.4464G>C	c.(4462-4464)CTG>CTC	p.L1488L	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Silent_p.L1205L|PARP14_uc003efs.1_Silent_p.L1205L	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		ACATTTCCCTGGACCATAAGA	0.408													4	192					0	0	0.00024832	0	0
KALRN	8997	broad.mit.edu	37	3	124415066	124415066	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:124415066G>A	uc003ehg.2	+	54	7790	c.7663G>A	c.(7663-7665)GGG>AGG	p.G2555R	KALRN_uc003ehk.2_Missense_Mutation_p.G858R	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2554	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AAATGACCACGGGACCACATC	0.373													8	36					0	0	0.000157383	0	0
TMEM22	80723	broad.mit.edu	37	3	136574014	136574014	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:136574014A>T	uc003erf.3	+	2	926	c.712A>T	c.(712-714)ATC>TTC	p.I238F	TMEM22_uc003erg.3_Missense_Mutation_p.I238F|TMEM22_uc010hub.2_Missense_Mutation_p.I238F	NM_001097600	NP_001091069	Q8TBE7	TMM22_HUMAN	transmembrane protein 22	238	DUF6 1.|Helical; (Potential).					Golgi apparatus|integral to membrane				ovary(1)	1						TCTTGTCATGATCCCAAACAT	0.423													18	46					0	0	0.000958276	0	0
ESYT3	83850	broad.mit.edu	37	3	138179482	138179482	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:138179482C>T	uc003esk.2	+	7	994	c.768C>T	c.(766-768)ACC>ACT	p.T256T	ESYT3_uc010hug.2_RNA	NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	256						integral to membrane|plasma membrane					0						CTGGCCTGACCAACCTGCTGG	0.602													41	136					0	0	0.000680045	0	0
FAM194A	131831	broad.mit.edu	37	3	150403761	150403761	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:150403761C>G	uc003eyg.2	-	5	715	c.658G>C	c.(658-660)GAG>CAG	p.E220Q	FAM194A_uc003eyh.2_Missense_Mutation_p.E74Q	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	220										skin(2)|ovary(1)	3						ACCTCCAGCTCATATAAAATA	0.333													18	72					0	0	0.00047179	0	0
FAM194A	131831	broad.mit.edu	37	3	150403780	150403780	+	Silent	SNP	C	T	T	rs145250976		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:150403780C>T	uc003eyg.2	-	5	696	c.639G>A	c.(637-639)TCG>TCA	p.S213S	FAM194A_uc003eyh.2_Silent_p.S67S	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	213										skin(2)|ovary(1)	3						TATTTAGTTTCGACTCTTCTG	0.308													14	63					0	0	0.000566183	0	0
SI	6476	broad.mit.edu	37	3	164733005	164733006	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:164733005_164733006CC>TT	uc003fei.2	-	33	3966_3967	c.3904_3905GG>AA	c.(3904-3906)GGA>AAA	p.G1302K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1302	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTTTCATTTCCTGAAATTGCT	0.347										HNSCC(35;0.089)			6	20					0	0	6.4e-05	0	0
MECOM	2122	broad.mit.edu	37	3	169099040	169099040	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:169099040C>T	uc011bpj.1	-	2	713	c.310G>A	c.(310-312)GAA>AAA	p.E104K	MECOM_uc003ffl.2_Missense_Mutation_p.E76K|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Missense_Mutation_p.E104K|MECOM_uc011bpl.1_Missense_Mutation_p.E104K	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CCAAACTTTTCACCTACTTCG	0.433													22	56					0	0	0.000375601	0	0
NDUFB5	4711	broad.mit.edu	37	3	179341806	179341806	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:179341806C>T	uc003fkc.2	+	6	577	c.548C>T	c.(547-549)CCG>CTG	p.P183L	NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_Missense_Mutation_p.P131L	NM_002492	NP_002483	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	183					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	GATCATTCTCCGAAAGCAACT	0.333													14	29					0	0	0.000308642	0	0
ABCC5	10057	broad.mit.edu	37	3	183685555	183685555	+	Splice_Site	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:183685555C>A	uc003fmg.2	-	12	1927	c.1762_splice	c.e12-1	p.G588_splice	ABCC5_uc011bqt.1_Splice_Site_p.G116_splice|ABCC5_uc010hxl.2_Splice_Site_p.G588_splice	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5							integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCAGTTTACCCTGGACAAGGC	0.433													8	117					0.000274275	0.00152761	0.000274275	1	0
CPN2	1370	broad.mit.edu	37	3	194062895	194062895	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:194062895G>A	uc003fts.2	-	2	627	c.537C>T	c.(535-537)AAC>AAT	p.N179N		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	179	LRR 4.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GGGCCAGGAGGTTCTGGGCCA	0.647													9	28					0	0	0.000442599	0	0
LOC220729	220729	broad.mit.edu	37	3	197348629	197348629	+	RNA	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr3:197348629G>A	uc011bug.1	-	4		c.462C>T			LOC220729_uc003fxw.2_RNA|LOC220729_uc003fxy.2_RNA|LOC220729_uc010iao.1_Intron					Homo sapiens cDNA FLJ60865 complete cds, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC 1.3.5.1).												0						CCACACAGCAGCACCGATGGG	0.562													5	28					0	0	0.000602214	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2307182	2307183	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:2307182_2307183GG>AA	uc003gex.1	-	8	1203_1204	c.884_885CC>TT	c.(883-885)CCC>CTT	p.P295L	ZFYVE28_uc011bvk.1_Missense_Mutation_p.P225L|ZFYVE28_uc011bvl.1_Missense_Mutation_p.P265L|ZFYVE28_uc003gew.1_Missense_Mutation_p.P181L	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	295					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CTGCGCGGATGGGGAACTCCAC	0.629													8	39					0	0	6.4e-05	0	0
FAM193A	8603	broad.mit.edu	37	4	2701826	2701826	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:2701826C>T	uc010icl.2	+	17	3405	c.3054C>T	c.(3052-3054)CTC>CTT	p.L1018L	FAM193A_uc010ick.2_Silent_p.L1218L|FAM193A_uc003gfd.2_Silent_p.L1018L|FAM193A_uc011bvm.1_Silent_p.L1040L|FAM193A_uc011bvn.1_Silent_p.L1018L|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Silent_p.L872L	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	1018										ovary(3)	3						AATTTCTCCTCCCCAAGGAGG	0.547													32	41					0	0	0.000409698	0	0
TNIP2	79155	broad.mit.edu	37	4	2746636	2746636	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:2746636C>T	uc003gfg.2	-	4	781	c.694G>A	c.(694-696)GCC>ACC	p.A232T	TNIP2_uc003gff.2_Missense_Mutation_p.A125T|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	232						cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCCCTGCTGGCGTTGTAGCGC	0.612													14	29					0	0	0.000219431	0	0
EVC2	132884	broad.mit.edu	37	4	5687164	5687164	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:5687164G>A	uc003gij.2	-	6	803	c.749C>T	c.(748-750)GCT>GTT	p.A250V	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.A170V	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	250						integral to membrane				large_intestine(3)|ovary(2)	5						GAGGTCTCCAGCCTGGAGCGT	0.587													13	58					0	0	0.000151284	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229706	8229706	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:8229706C>T	uc003gkv.3	+	12	2386	c.2285C>T	c.(2284-2286)CCT>CTT	p.P762L	SH3TC1_uc003gkw.3_Missense_Mutation_p.P686L|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	762							binding			large_intestine(2)|pancreas(1)	3						CACAGCCTCCCTGCCCAAACT	0.692													5	20					0	0	8.12818e-05	0	0
GPR78	27201	broad.mit.edu	37	4	8582880	8582880	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:8582880G>A	uc003glk.2	+	1	590	c.171G>A	c.(169-171)GCG>GCA	p.A57A	CPZ_uc003gll.2_RNA	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	57	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						TGCTGGCGGCGCTGGACATGC	0.662													6	23					0	0	0.00116845	0	0
CPZ	8532	broad.mit.edu	37	4	8621144	8621144	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:8621144G>A	uc003glm.2	+	11	1885	c.1759G>A	c.(1759-1761)GGA>AGA	p.G587R	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.G450R|CPZ_uc003glo.2_Missense_Mutation_p.G576R|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	587					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						TCTGGGGATGGGACCCAAGAA	0.627													11	36					0	0	0.00136819	0	0
CC2D2A	57545	broad.mit.edu	37	4	15556783	15556783	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:15556783A>G	uc010idv.2	+	21	2820	c.2575A>G	c.(2575-2577)AAG>GAG	p.K859E	CC2D2A_uc003gnx.2_Missense_Mutation_p.K810E|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	859					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						AGCAGAGTCCAAGCTCGACCC	0.468													8	33					0	0	0.000274275	0	0
LDB2	9079	broad.mit.edu	37	4	16504347	16504347	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:16504347C>T	uc003goz.2	-	8	1357	c.1041G>A	c.(1039-1041)GGG>GGA	p.G347G	LDB2_uc003gpa.2_3'UTR|LDB2_uc003gpb.2_Silent_p.G345G|LDB2_uc011bxh.1_Silent_p.G319G|LDB2_uc010iee.2_3'UTR|LDB2_uc003goy.2_Silent_p.G222G|LDB2_uc011bxi.1_3'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	347							LIM domain binding|transcription cofactor activity				0						GGCTGTTGTTCCCCAGCGCGG	0.527													41	143					0	0	0.00148497	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962567	69962567	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:69962567C>T	uc003heg.3	+	1	375	c.329C>T	c.(328-330)TCA>TTA	p.S110L	UGT2B7_uc010ihq.2_Missense_Mutation_p.S110L	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	110					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TTATATTTTTCACAAGTACAG	0.303													14	31					0	0	0.000219431	0	0
DMP1	1758	broad.mit.edu	37	4	88583543	88583543	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:88583543G>A	uc003hqv.2	+	6	717	c.613G>A	c.(613-615)GGA>AGA	p.G205R	DMP1_uc003hqw.2_Missense_Mutation_p.G189R	NM_004407	NP_004398	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1 isoform 1	205					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			pancreas(1)|skin(1)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GAGCAGCCATGGAGACGGCTC	0.572													8	34					0	0	0.000274275	0	0
UNC5C	8633	broad.mit.edu	37	4	96137290	96137290	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:96137290C>T	uc003htp.1	-	10	1872	c.1718G>A	c.(1717-1719)AGG>AAG	p.R573K	UNC5C_uc010ilc.1_Missense_Mutation_p.R592K|UNC5C_uc003htq.2_Missense_Mutation_p.R592K	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	573	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AGTTTCTTTCCTGTGTACAGT	0.418													11	39					0	0	0.000978159	0	0
ADH7	131	broad.mit.edu	37	4	100349080	100349080	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:100349080G>C	uc003huv.1	-	5	549	c.450C>G	c.(448-450)CAC>CAG	p.H150Q		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	150				HH -> GR (in Ref. 11; AA sequence).	ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	TCATGAAGTGGTGGACTGGTT	0.418													17	103					0	0	0.00121646	0	0
DAPP1	27071	broad.mit.edu	37	4	100756893	100756893	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:100756893T>C	uc003hvf.3	+	2	305	c.215T>C	c.(214-216)CTC>CCC	p.L72P	DAPP1_uc011cek.1_Missense_Mutation_p.L72P|DAPP1_uc010ilh.2_Missense_Mutation_p.L72P	NM_014395	NP_055210	Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and	72	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity				0				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		CTGTACTCTCTCTCTGTGAGG	0.507													11	34					0	0	0.00136819	0	0
BANK1	55024	broad.mit.edu	37	4	102783700	102783700	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:102783700C>T	uc003hvy.3	+	4	916	c.642C>T	c.(640-642)TTC>TTT	p.F214F	BANK1_uc003hvx.3_Silent_p.F199F|BANK1_uc010ill.2_Silent_p.F81F|BANK1_uc003hvz.3_Silent_p.F184F	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	214	DBB.				B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GTGAAATATTCATAATTTTGA	0.318													16	38					0	0	0.000566183	0	0
GSTCD	79807	broad.mit.edu	37	4	106766630	106766630	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:106766630C>T	uc003hxz.3	+	12	1870	c.1798C>T	c.(1798-1800)CGA>TGA	p.R600*	GSTCD_uc003hxy.3_Nonsense_Mutation_p.R513*|GSTCD_uc011cfb.1_Nonsense_Mutation_p.R223*	NM_001031720	NP_001026890	Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain	600						cytoplasm	rRNA methyltransferase activity			breast(1)|central_nervous_system(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		GGATCTGGATCGAGCAAGAGC	0.458													12	35					0	0	0.00136819	0	0
ANK2	287	broad.mit.edu	37	4	114275856	114275856	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:114275856C>T	uc003ibe.3	+	38	6182	c.6082C>T	c.(6082-6084)CGG>TGG	p.R2028W	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.R2043W	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1995					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGGTAAAGTTCGGGTAGAAAA	0.463													16	47					0	0	0.000308642	0	0
NDST4	64579	broad.mit.edu	37	4	115856431	115856431	+	Silent	SNP	T	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:115856431T>G	uc003ibu.2	-	6	2146	c.1467A>C	c.(1465-1467)CCA>CCC	p.P489P	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	489	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGGGTCCTCCTGGATATTCTT	0.403													12	64					0	0	0.000308642	0	0
ANKRD50	57182	broad.mit.edu	37	4	125631414	125631414	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:125631414C>T	uc003ifg.3	-	1	519	c.253G>A	c.(253-255)GCC>ACC	p.A85T	ANKRD50_uc011cgo.1_Intron|ANKRD50_uc010inw.2_Missense_Mutation_p.A85T	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	85										central_nervous_system(1)	1						GTACATAGGGCCGTCTTGCCA	0.502													11	39					0	0	0.000151284	0	0
FAT4	79633	broad.mit.edu	37	4	126336328	126336328	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:126336328C>T	uc003ifj.3	+	5	6210	c.6210C>T	c.(6208-6210)TTC>TTT	p.F2070F	FAT4_uc011cgp.1_Silent_p.F368F	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2070	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGTTGTTTTCAAAGCTCAAG	0.393													53	78					0	0	0.000781405	0	0
TLR2	7097	broad.mit.edu	37	4	154626220	154626220	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:154626220C>G	uc003inq.2	+	3	2380	c.2161C>G	c.(2161-2163)CAT>GAT	p.H721D	TLR2_uc003inr.2_Missense_Mutation_p.H721D|TLR2_uc003ins.2_Missense_Mutation_p.H721D	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	721	TIR.|Cytoplasmic (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				GGACTTCTCCCATTTCCGTCT	0.433													4	93					0	0	0.00024832	0	0
TRIML2	205860	broad.mit.edu	37	4	189022313	189022313	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr4:189022313C>T	uc003izl.2	-	3	263	c.227G>A	c.(226-228)AGA>AAA	p.R76K	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.R126K|TRIML2_uc011clf.1_Missense_Mutation_p.R126K	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	76	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTCCTGCTGTCTCTGGAGATT	0.428													31	22					0	0	0.00058488	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	143613	143613	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:143613C>T	uc003jak.2	+	3	788	c.738C>T	c.(736-738)ATC>ATT	p.I246I		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	246					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TCCATAGCATCCCCAGGTGGG	0.662													6	27					0	0	0.000157383	0	0
TERT	7015	broad.mit.edu	37	5	1293435	1293435	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:1293435C>T	uc003jcb.1	-	2	1624	c.1566G>A	c.(1564-1566)AGG>AGA	p.R522R	TERT_uc003jca.1_Silent_p.R522R|TERT_uc003jcc.1_Silent_p.R522R|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	522	Required for oligomerization.|RNA-interacting domain 2.		R -> K (associated with acute myeloid leukemia).		anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CACCTGGGCTCCTGCGCAGCC	0.642									TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				11	44					0	0	0.000978159	0	0
IRX1	79192	broad.mit.edu	37	5	3599467	3599467	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:3599467C>T	uc003jde.2	+	2	457	c.405C>T	c.(403-405)ACC>ACT	p.T135T		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	135	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						AGAACGCCACCCGCGAGAGCA	0.652													16	24					0	0	0.000566183	0	0
DNAH5	1767	broad.mit.edu	37	5	13714555	13714555	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:13714555C>T	uc003jfd.2	-	75	13126	c.13084G>A	c.(13084-13086)GAT>AAT	p.D4362N	DNAH5_uc003jfc.2_Missense_Mutation_p.D530N	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4362					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCCAGCATATCATCAGCCAGC	0.572									Kartagener_syndrome				29	46					0	0	0.000491102	0	0
DNAH5	1767	broad.mit.edu	37	5	13823393	13823393	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:13823393C>T	uc003jfd.2	-	40	6708	c.6666G>A	c.(6664-6666)CTG>CTA	p.L2222L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2222					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTGCTGCTTCCAGTTCAGGGT	0.413									Kartagener_syndrome				27	104					0	0	0.00106085	0	0
PRLR	5618	broad.mit.edu	37	5	35072715	35072715	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:35072715C>T	uc003jjm.2	-	6	1035	c.505G>A	c.(505-507)GAA>AAA	p.E169K	PRLR_uc003jjg.1_Missense_Mutation_p.E169K|PRLR_uc003jjh.1_Missense_Mutation_p.E169K|PRLR_uc003jji.1_Missense_Mutation_p.E98K|PRLR_uc003jjj.1_Missense_Mutation_p.E169K|PRLR_uc003jjk.1_Missense_Mutation_p.E98K|PRLR_uc003jjl.3_Missense_Mutation_p.E68K|PRLR_uc010iuw.1_Missense_Mutation_p.E98K	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	169	Fibronectin type-III 2.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AATCGAATTTCATACAGGAGC	0.443													14	58					0	0	0.000422831	0	0
UGT3A1	133688	broad.mit.edu	37	5	35991296	35991297	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:35991296_35991297CC>TT	uc003jjv.1	-	1	203_204	c.46_47GG>AA	c.(46-48)GGG>AAG	p.G16K	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.G16K|UGT3A1_uc011cor.1_Missense_Mutation_p.G16K|UGT3A1_uc003jjy.1_Intron	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	16						integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGCAGGACCCCAGAAAGAAGG	0.619													22	40					0	0	6.4e-05	0	0
UGT3A2	167127	broad.mit.edu	37	5	36037996	36037996	+	Nonsense_Mutation	SNP	G	A	A	rs147315371		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:36037996G>A	uc003jjz.1	-	6	1291	c.1198C>T	c.(1198-1200)CGA>TGA	p.R400*	UGT3A2_uc011cos.1_Nonsense_Mutation_p.R366*|UGT3A2_uc011cot.1_Nonsense_Mutation_p.R98*	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	400	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCTTCTACTCGGACCATGTTT	0.478													20	91					0	0	0.000958276	0	0
LIFR	3977	broad.mit.edu	37	5	38482087	38482087	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:38482087C>T	uc010ive.1	-	20	3236	c.2904G>A	c.(2902-2904)GGG>GGA	p.G968G	LIFR_uc003jli.2_Silent_p.G968G	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	968	Cytoplasmic (Potential).				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					CCTGTGCAGTCCCTCCAGCTT	0.468			T	PLAG1	salivary adenoma								38	120					0	0	0.00170553	0	0
FYB	2533	broad.mit.edu	37	5	39203057	39203057	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:39203057C>T	uc003jls.2	-	1	73	c.6G>A	c.(4-6)GCG>GCA	p.A2A	FYB_uc003jlt.2_Silent_p.A2A|FYB_uc003jlu.2_Silent_p.A2A|FYB_uc011cpl.1_Silent_p.A12A	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	2					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TGTTATATTTCGCCATGAGGG	0.433													22	56					0	0	0.000878237	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41019027	41019027	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:41019027C>T	uc003jmj.3	-	25	3025	c.2535G>A	c.(2533-2535)CTG>CTA	p.L845L	HEATR7B2_uc003jmi.3_Silent_p.L400L	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	845							binding			ovary(6)|central_nervous_system(2)	8						CTTCACTTTTCAGATTTTCCA	0.473													16	27					0	0	0.000422831	0	0
PDE4D	5144	broad.mit.edu	37	5	58289244	58289244	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:58289244G>A	uc003jsa.2	-	7	1142	c.970C>T	c.(970-972)CGG>TGG	p.R324W	PDE4D_uc003jrx.2_Missense_Mutation_p.R188W|PDE4D_uc003jry.2_Missense_Mutation_p.R22W|PDE4D_uc003jrz.2_Missense_Mutation_p.R260W|PDE4D_uc003jsb.2_Missense_Mutation_p.R263W|PDE4D_uc003jrt.2_Missense_Mutation_p.R22W|PDE4D_uc003jru.2_Missense_Mutation_p.R100W|PDE4D_uc003jrv.2_Missense_Mutation_p.R194W|PDE4D_uc003jrw.2_Missense_Mutation_p.R202W|PDE4D_uc010iwi.1_3'UTR|PDE4D_uc003jrs.2_Missense_Mutation_p.R33W	NM_001104631	NP_001098101	Q08499	PDE4D_HUMAN	phosphodiesterase 4D isoform 1	324					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	TTTCCAGACCGACTCATTTCA	0.318													39	28					0	0	0.000781405	0	0
BDP1	55814	broad.mit.edu	37	5	70805569	70805569	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:70805569C>T	uc003kbp.1	+	17	2913	c.2650C>T	c.(2650-2652)CCC>TCC	p.P884S	BDP1_uc003kbn.1_Missense_Mutation_p.P884S|BDP1_uc003kbo.2_Missense_Mutation_p.P884S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	884	2.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGCCATTTCTCCCAGGGAGAA	0.418													18	19					0	0	0.000566183	0	0
TTC37	9652	broad.mit.edu	37	5	94842677	94842678	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:94842677_94842678GT>AA	uc003klb.2	-	30	3322_3323	c.3052_3053AC>TT	c.(3052-3054)ACT>TTT	p.T1018F		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1018							binding			ovary(3)|pancreas(1)	4						AACATTGTAAGTATCTTGGTCT	0.312													37	31					0	0	6.4e-05	0	0
ELL2	22936	broad.mit.edu	37	5	95242469	95242469	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:95242469G>A	uc003klr.3	-	5	849	c.499C>T	c.(499-501)CGG>TGG	p.R167W		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	167					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		GGTGCTTTCCGAATTTGCACT	0.423													34	32					0	0	0.000374591	0	0
PAM	5066	broad.mit.edu	37	5	102361011	102361011	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:102361011C>T	uc003knw.2	+	23	3035	c.2662C>T	c.(2662-2664)CGG>TGG	p.R888W	PAM_uc003kns.2_Missense_Mutation_p.R781W|PAM_uc003knt.2_Missense_Mutation_p.R888W|PAM_uc003knu.2_Intron|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Missense_Mutation_p.R790W|PAM_uc003knz.2_Missense_Mutation_p.R128W	NM_000919	NP_000910	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	888	Cytoplasmic (Potential).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CATATTTATTCGGTGGAAAAA	0.473													56	24					0	0	0.000781405	0	0
FSTL4	23105	broad.mit.edu	37	5	132535168	132535168	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:132535168G>A	uc003kyn.1	-	16	2366	c.2148C>T	c.(2146-2148)ATC>ATT	p.I716I	FSTL4_uc003kym.1_Silent_p.I365I	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	716						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCGCACTGTGATCTCCTGCA	0.572													25	17					0	0	0.000375601	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475705	140475705	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:140475705C>T	uc003lil.2	+	1	1469	c.1331C>T	c.(1330-1332)TCC>TTC	p.S444F	PCDHB2_uc003lim.1_Missense_Mutation_p.S105F	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	444	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGCTGGTCTCCGACGTCAAT	0.607													43	36					0	0	0.000680045	0	0
PCDHB18	54660	broad.mit.edu	37	5	140616448	140616448	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:140616448C>T	uc003ljc.1	+	1	2511	c.2163C>T	c.(2161-2163)CTC>CTT	p.L721L		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						TTCCCAATCTCCTGTCCCGCG	0.517													18	10					0	0	0.00074312	0	0
SLC36A2	153201	broad.mit.edu	37	5	150704867	150704867	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:150704867G>A	uc003lty.2	-	8	1120	c.990C>T	c.(988-990)AGC>AGT	p.S330S	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Silent_p.S132S|SLC36A2_uc010jhv.2_Silent_p.S330S	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	330	Extracellular (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGGTTAAGGCTTATGCTGG	0.408													9	5					0	0	0.000274275	0	0
ATP10B	23120	broad.mit.edu	37	5	160039886	160039886	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:160039886C>T	uc003lym.1	-	18	3547	c.2700G>A	c.(2698-2700)ACG>ACA	p.T900T	ATP10B_uc010jit.1_Silent_p.T217T|ATP10B_uc003lyn.2_Silent_p.T458T	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	900	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGTGGCAATCGTATCTGGAA	0.507													20	11					0	0	0.000229342	0	0
GABRG2	2566	broad.mit.edu	37	5	161569245	161569245	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:161569245C>T	uc003lyz.3	+	7	1203	c.845C>T	c.(844-846)CCC>CTC	p.P282L	GABRG2_uc010jjc.2_Missense_Mutation_p.P322L|GABRG2_uc003lyy.3_Missense_Mutation_p.P282L|GABRG2_uc011dej.1_Missense_Mutation_p.P187L	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	282	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ACCTATATCCCCTGCACACTC	0.438													63	41					0	0	0.000781405	0	0
WWC1	23286	broad.mit.edu	37	5	167850762	167850763	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:167850762_167850763CC>TT	uc003lzu.2	+	11	1592_1593	c.1499_1500CC>TT	c.(1498-1500)ACC>ATT	p.T500I	WWC1_uc003lzv.2_Missense_Mutation_p.T500I|WWC1_uc011den.1_Missense_Mutation_p.T500I|WWC1_uc003lzw.2_Missense_Mutation_p.T299I	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	500					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		TGCATCACCACCATCCACGAGG	0.639													32	21					0	0	6.4e-05	0	0
SLIT3	6586	broad.mit.edu	37	5	168119619	168119619	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:168119619C>T	uc003mab.2	-	29	3589	c.3169G>A	c.(3169-3171)GGA>AGA	p.G1057R	SLIT3_uc010jjg.2_Missense_Mutation_p.G1064R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1057	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACCTGAATCCTTTGTCCAGG	0.547													31	21					0	0	0.00178596	0	0
ZFP2	80108	broad.mit.edu	37	5	178358836	178358836	+	Silent	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr5:178358836T>C	uc003mjn.1	+	5	1031	c.522T>C	c.(520-522)ACT>ACC	p.T174T	ZFP2_uc010jky.2_Silent_p.T174T|ZFP2_uc010jkx.1_Silent_p.T174T	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	174	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TGAATCTTACTGTCCATCAAC	0.403													18	11					0	0	0.00152264	0	0
GMDS	2762	broad.mit.edu	37	6	1961041	1961041	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:1961041C>T	uc003mtq.2	-	5	695	c.505G>A	c.(505-507)GAG>AAG	p.E169K		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	169					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		GGGGTGGTCTCCTTCTGGGGT	0.502													27	88					0	0	0.000339439	0	0
FARS2	10667	broad.mit.edu	37	6	5431306	5431306	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:5431306C>T	uc010jnv.1	+	4	1141	c.805C>T	c.(805-807)CCT>TCT	p.P269S	FARS2_uc003mwr.2_Missense_Mutation_p.P269S|FARS2_uc003mws.1_Missense_Mutation_p.P269S	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	269					phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	CTGCTACTTCCCTTTTACACA	0.428													31	79					0	0	0.000491102	0	0
KIF13A	63971	broad.mit.edu	37	6	17834269	17834269	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:17834269C>T	uc003ncg.3	-	12	1294	c.1189G>A	c.(1189-1191)GAA>AAA	p.E397K	KIF13A_uc003ncf.2_Missense_Mutation_p.E397K|KIF13A_uc003nch.3_Missense_Mutation_p.E397K|KIF13A_uc003nci.3_Missense_Mutation_p.E397K|KIF13A_uc003ncj.2_Missense_Mutation_p.E73K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	397	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCAGACTCTTCGAGCTTCTCC	0.383													6	26					0	0	0.000274275	0	0
GPLD1	2822	broad.mit.edu	37	6	24447166	24447166	+	Missense_Mutation	SNP	C	T	T	rs140138874	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:24447166C>T	uc003ned.1	-	18	1831	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	574	FG-GAP 4.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						AAGTCTTCCTCGCCTCTCACC	0.488													31	38					0	0	0.00058488	0	0
SLC17A1	6568	broad.mit.edu	37	6	25799114	25799114	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:25799114G>A	uc003nfh.3	-	12	1419	c.1303C>T	c.(1303-1305)CTG>TTG	p.L435L	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Silent_p.L433L|SLC17A1_uc010jqc.1_Silent_p.L379L	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	435	Helical; (Potential).				sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GCTGCCATCAGGATGAAGGTT	0.358													16	34					0	0	0.000422831	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403789	28403789	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:28403789C>T	uc003nli.3	-	2	436	c.255G>A	c.(253-255)GAG>GAA	p.E85E	ZSCAN23_uc003nlh.2_RNA|ZSCAN23_uc010jrf.1_Intron|ZSCAN23_uc011dli.1_Silent_p.E85E	NM_001012455	NP_001012458	Q3MJ62	ZSC23_HUMAN	zinc finger protein 390	85	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTAGGATCTGCTCCTTGGTGT	0.607													6	31					0	0	0.000442599	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187468	32187468	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:32187468G>C	uc003obb.2	-	8	1550	c.1411C>G	c.(1411-1413)CGT>GGT	p.R471G	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.R471G	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	471	EGF-like 11; calcium-binding (Potential).|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCCTCACAACGGGAGCCTGTG	0.622													4	283					0	0	0.000602214	0	0
CPNE5	57699	broad.mit.edu	37	6	36762372	36762372	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:36762372G>A	uc003omr.1	-	7	526	c.459C>T	c.(457-459)TCC>TCT	p.S153S	CPNE5_uc003oms.1_Silent_p.S115S	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	153	C2 2.									skin(1)	1						CGTACCCGTTGGACACAGCTG	0.592													12	8					0	0	0.00136819	0	0
PI16	221476	broad.mit.edu	37	6	36931063	36931063	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:36931063C>T	uc003ona.2	+	5	1273	c.945C>T	c.(943-945)ATC>ATT	p.I315I	PI16_uc003omz.1_Intron|PI16_uc003onb.2_Intron|PI16_uc011dts.1_Silent_p.I86I	NM_153370	NP_699201	Q6UXB8	PI16_HUMAN	protease inhibitor 16 precursor	315	Extracellular (Potential).					extracellular region|integral to membrane	peptidase inhibitor activity				0						ATGTTCCTATCCCAAAATCAG	0.527													15	40					0	0	0.00152264	0	0
FTSJD2	23070	broad.mit.edu	37	6	37420894	37420894	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:37420894C>T	uc003ons.2	+	7	934	c.681C>T	c.(679-681)ATC>ATT	p.I227I	FTSJD2_uc010jwu.2_Intron	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	227					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ATGAGATGATCCGAGGAGTCT	0.507													61	75					0	0	0.000781405	0	0
DNAH8	1769	broad.mit.edu	37	6	38835886	38835886	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:38835886C>T	uc003ooe.1	+	46	6691	c.6091C>T	c.(6091-6093)CTT>TTT	p.L2031F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ATTGAGGACTCTTGGATCTCA	0.363													32	46					0	0	0.000491102	0	0
KIF6	221458	broad.mit.edu	37	6	39602662	39602662	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:39602662C>T	uc003oot.2	-	5	567	c.472G>A	c.(472-474)GAT>AAT	p.D158N	KIF6_uc010jxa.1_5'UTR|KIF6_uc011dua.1_Missense_Mutation_p.D158N|KIF6_uc010jxb.1_Missense_Mutation_p.D158N	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	158	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGTCTTGGATCCAAAAGATCA	0.358													30	50					0	0	0.00178596	0	0
DAAM2	23500	broad.mit.edu	37	6	39847153	39847153	+	Missense_Mutation	SNP	C	T	T	rs150676991	by1000genomes	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:39847153C>T	uc003oow.2	+	14	1901	c.1745C>T	c.(1744-1746)CCT>CTT	p.P582L	DAAM2_uc010jxc.2_Missense_Mutation_p.P582L|DAAM2_uc003oox.2_Missense_Mutation_p.P582L	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	582	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CTGCCCCTCCCTCAGGACCCC	0.517													4	26					0	0	0.000602214	0	0
GPR116	221395	broad.mit.edu	37	6	46874483	46874483	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:46874483C>T	uc003oyo.3	-	2	306	c.17G>A	c.(16-18)AGA>AAA	p.R6K	GPR116_uc003oyp.3_Missense_Mutation_p.R6K|GPR116_uc003oyq.3_Missense_Mutation_p.R6K|GPR116_uc003oyr.2_Missense_Mutation_p.R6K|uc003oys.2_Intron	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	6					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			CAAAGTGGTTCTCCTTGGGGA	0.358													38	39					0	0	0.00111076	0	0
OPN5	221391	broad.mit.edu	37	6	47754302	47754302	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:47754302G>A	uc003ozc.2	+	2	187	c.182G>A	c.(181-183)CGA>CAA	p.R61Q	OPN5_uc003ozd.2_5'Flank	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	61	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						TCTTCTAGACGAAAGAAGAAG	0.378													27	45					0	0	0.000586117	0	0
COL21A1	81578	broad.mit.edu	37	6	56044434	56044434	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:56044434C>T	uc003pcs.2	-	3	814	c.582G>A	c.(580-582)GTG>GTA	p.V194V	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Silent_p.V194V|COL21A1_uc003pcu.1_Silent_p.V194V	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	194	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TATAGTCTTCCACATAAAACA	0.343													10	38					0	0	0.000442599	0	0
COL19A1	1310	broad.mit.edu	37	6	70847578	70847578	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:70847578G>A	uc003pfc.1	+	19	1502	c.1385G>A	c.(1384-1386)GGT>GAT	p.G462D	COL19A1_uc010kam.1_Missense_Mutation_p.G358D	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	462	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TCTTGAAAGGGTGAAACTGGA	0.408													28	88					0	0	0.000814825	0	0
SLC17A5	26503	broad.mit.edu	37	6	74351495	74351495	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:74351495G>A	uc003phn.3	-	3	572	c.444C>T	c.(442-444)GTC>GTT	p.V148V	SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Missense_Mutation_p.P47S	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	148	Helical; (Potential).				anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						ACAGGGTGAGGACAGCAGTGC	0.453													33	65					0	0	0.000409698	0	0
FILIP1	27145	broad.mit.edu	37	6	76023520	76023520	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:76023520G>A	uc003pia.2	-	5	2401	c.2028C>T	c.(2026-2028)TTC>TTT	p.F676F	FILIP1_uc003phy.1_Silent_p.F676F|FILIP1_uc003phz.2_Silent_p.F577F|FILIP1_uc010kbe.2_Silent_p.F679F|FILIP1_uc003pib.1_Silent_p.F428F	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	676	Potential.									skin(3)|ovary(1)	4						GTTGAGAGAGGAAGTTAGCCT	0.433													54	107					0	0	0.000781405	0	0
BCKDHB	594	broad.mit.edu	37	6	81053415	81053415	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:81053415C>T	uc003pjd.2	+	10	1140	c.1073C>T	c.(1072-1074)TCA>TTA	p.S358L	BCKDHB_uc003pje.2_Missense_Mutation_p.S358L	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta	358					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		GCTCCTATATCAAGAGTATGT	0.378													16	44					0	0	0.000308642	0	0
SIM1	6492	broad.mit.edu	37	6	100901681	100901681	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:100901681G>A	uc003pqj.3	-	2	422	c.215C>T	c.(214-216)CCC>CTC	p.P72L	SIM1_uc010kcu.2_Missense_Mutation_p.P72L	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	72					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GTTGTCCAGGGGGCTGGTCCG	0.622													11	41					0	0	0.000673444	0	0
LIN28B	389421	broad.mit.edu	37	6	105526589	105526589	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:105526589G>A	uc003pqv.1	+	4	887	c.684G>A	c.(682-684)ACG>ACA	p.T228T	LIN28B_uc010kda.1_3'UTR	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	228					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				CTTCCTCCACGAAGTCATCTA	0.488													8	26					0	0	0.000673444	0	0
ARMC2	84071	broad.mit.edu	37	6	109225519	109225519	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:109225519G>A	uc003pss.3	+	8	1108	c.934G>A	c.(934-936)GGA>AGA	p.G312R	ARMC2_uc011eao.1_Missense_Mutation_p.G147R	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	312	ARM 2.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		TAAATTTAAGGGAAGAAGTAT	0.383													56	86					0	0	0.000781405	0	0
COL10A1	1300	broad.mit.edu	37	6	116442962	116442962	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:116442962C>T	uc003pwm.2	-	3	413	c.317G>A	c.(316-318)GGG>GAG	p.G106E	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	106	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		ACCTGGTTTCCCTACAGCTGA	0.602													5	25					0	0	8.12818e-05	0	0
ROS1	6098	broad.mit.edu	37	6	117662729	117662729	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:117662729C>T	uc003pxp.1	-	29	4935	c.4736G>A	c.(4735-4737)AGA>AAA	p.R1579K	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1579	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTGAGATTCTCTCCAAGATAT	0.428			T	GOPC|ROS1	glioblastoma|NSCLC								13	29					0	0	0.000219431	0	0
C6orf204	387119	broad.mit.edu	37	6	118886834	118886834	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:118886834G>A	uc003pxz.1	-	3	1466	c.878C>T	c.(877-879)TCC>TTC	p.S293F	C6orf204_uc003pya.1_Missense_Mutation_p.S296F|C6orf204_uc003pyb.2_Missense_Mutation_p.S293F|C6orf204_uc011ebj.1_Missense_Mutation_p.S191F|C6orf204_uc003pyc.2_Missense_Mutation_p.S296F|C6orf204_uc011ebl.1_Missense_Mutation_p.S191F	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	293						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		AGTCCTTACGGAAGGCTGAAT	0.463													16	28					0	0	0.000566183	0	0
NMBR	4829	broad.mit.edu	37	6	142409748	142409749	+	Missense_Mutation	DNP	AT	TG	TG			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:142409748_142409749AT>TG	uc003qiu.2	-	1	188_189	c.47_48AT>CA	c.(46-48)AAT>ACA	p.N16T		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	16	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		AACCGCTCTCATTCGCGCCGGT	0.619													6	15					0	0	6.4e-05	0	0
ULBP3	79465	broad.mit.edu	37	6	150386606	150386606	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:150386606C>T	uc003qns.3	-	3	556	c.556G>A	c.(556-558)GTC>ATC	p.V186I	ULBP3_uc011eej.1_Missense_Mutation_p.V61I|ULBP3_uc011eek.1_Missense_Mutation_p.V137I	NM_024518	NP_078794	Q9BZM4	N2DL3_HUMAN	UL16 binding protein 3 precursor	186	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation	anchored to membrane|MHC class I protein complex	MHC class I receptor activity				0		Ovarian(120;0.12)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.45e-12)		CTCATTGAGACCATCTTGAAG	0.527													15	47					0	0	0.000308642	0	0
SYNE1	23345	broad.mit.edu	37	6	152847286	152847286	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:152847286C>T	uc010kiw.2	-	5	756	c.154G>A	c.(154-156)GAT>AAT	p.D52N	SYNE1_uc003qot.3_Missense_Mutation_p.D52N|SYNE1_uc003qou.3_Missense_Mutation_p.D52N|SYNE1_uc010kjb.1_Missense_Mutation_p.D52N|SYNE1_uc003qpa.1_Missense_Mutation_p.D52N	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	52	Actin-binding.|Cytoplasmic (Potential).|CH 1.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCAAAAAGATCGTCCACCACC	0.343										HNSCC(10;0.0054)			20	41					0	0	0.00047179	0	0
SYNJ2	8871	broad.mit.edu	37	6	158505156	158505156	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:158505156C>T	uc003qqx.1	+	22	3233	c.3158C>T	c.(3157-3159)CCC>CTC	p.P1053L	SYNJ2_uc003qqw.1_Missense_Mutation_p.P1053L|SYNJ2_uc003qqy.1_Missense_Mutation_p.P766L|SYNJ2_uc003qqz.1_Missense_Mutation_p.P670L|SYNJ2_uc003qra.1_Missense_Mutation_p.P396L|SYNJ2_uc010kjp.1_5'Flank	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1053	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CTGGCTCCTCCCAGCAAGTCA	0.557													30	82					0	0	0.000409698	0	0
SLC22A1	6580	broad.mit.edu	37	6	160557602	160557602	+	Silent	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:160557602C>G	uc003qtc.2	+	6	1086	c.981C>G	c.(979-981)ACC>ACG	p.T327T	SLC22A1_uc003qtd.2_Silent_p.T327T	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	327	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		AGGATGTCACCGAAAAGCTGA	0.607													21	57					0	0	0.000295444	0	0
MAP3K4	4216	broad.mit.edu	37	6	161470199	161470199	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:161470199C>T	uc003qtn.2	+	3	1037	c.895C>T	c.(895-897)CTT>TTT	p.L299F	MAP3K4_uc010kkc.1_Missense_Mutation_p.L299F|MAP3K4_uc003qto.2_Missense_Mutation_p.L299F|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	299					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TAATGAAATCCTTACTTTCAA	0.443													16	33					0	0	0.000308642	0	0
CHST12	55501	broad.mit.edu	37	7	2473051	2473051	+	Silent	SNP	C	T	T	rs147486579		TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:2473051C>T	uc003smc.2	+	2	912	c.777C>T	c.(775-777)TTC>TTT	p.F259F	CHST12_uc003smd.2_Silent_p.F259F	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	259	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GCAGCAAGTTCGAGCTGGAGA	0.632													42	56					0	0	0.000509022	0	0
SDK1	221935	broad.mit.edu	37	7	4152923	4152923	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:4152923T>A	uc003smx.2	+	24	3576	c.3437T>A	c.(3436-3438)TTT>TAT	p.F1146Y	SDK1_uc010kso.2_Missense_Mutation_p.F422Y	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1146	Fibronectin type-III 5.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCCTTTAGATTTCGAATGAAG	0.537													49	297					0	0	0.000781405	0	0
PAPOLB	56903	broad.mit.edu	37	7	4899799	4899799	+	Nonsense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:4899799A>T	uc003snk.2	-	1	1827	c.1643T>A	c.(1642-1644)TTG>TAG	p.L548*	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	547					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		ACTGCTAATCAATGGGCCTGT	0.453													59	84					0	0	0.000781405	0	0
RADIL	55698	broad.mit.edu	37	7	4917240	4917240	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:4917240C>T	uc003snj.1	-	2	704	c.531G>A	c.(529-531)ACG>ACA	p.T177T	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	177					cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CCTCACCTGCCGTGATGGTGT	0.612													11	47					0	0	0.000219431	0	0
MMD2	221938	broad.mit.edu	37	7	4950876	4950876	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:4950876G>C	uc003sno.3	-	5	563	c.367C>G	c.(367-369)CTG>GTG	p.L123V	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Missense_Mutation_p.L123V|MMD2_uc010ksq.2_Missense_Mutation_p.L123V	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	123	Helical; (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		CGAAGGTTCAGCCTGGGAGAG	0.642													2	10					0	0	6.4e-05	0	0
ABCB5	340273	broad.mit.edu	37	7	20782554	20782554	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:20782554C>T	uc003suw.3	+	16	2290	c.1744C>T	c.(1744-1746)CGC>TGC	p.R582C	ABCB5_uc010kuh.2_Missense_Mutation_p.R1027C	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	582	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CTATCCATGTCGCCCAGATGT	0.468													21	52					0	0	0.000375601	0	0
CREB5	9586	broad.mit.edu	37	7	28609991	28609991	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:28609991G>A	uc003szq.2	+	5	690	c.300G>A	c.(298-300)TCG>TCA	p.S100S	CREB5_uc003szo.2_Silent_p.S67S|CREB5_uc003szr.2_Silent_p.S93S	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	100					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AGAATATCTCGATGCATAATG	0.517													142	235					0	0	0.000781405	0	0
GHRHR	2692	broad.mit.edu	37	7	31011632	31011632	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:31011632C>T	uc003tbx.2	+	6	567	c.519C>T	c.(517-519)ATC>ATT	p.I173I	GHRHR_uc003tbw.1_Silent_p.I173I|GHRHR_uc003tby.2_Silent_p.I109I|GHRHR_uc003tbz.2_5'UTR	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	173	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CCACTTTTATCCTCAAGGCGG	0.567													38	43					0	0	0.00148497	0	0
EPDR1	54749	broad.mit.edu	37	7	37960619	37960619	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:37960619C>T	uc003tfp.2	+	1	457	c.438C>T	c.(436-438)ACC>ACT	p.T146T	EPDR1_uc003tfq.2_Silent_p.T146T|EPDR1_uc010kxh.2_5'Flank	NM_017549	NP_060019	Q9UM22	EPDR1_HUMAN	ependymin related protein 1 precursor	26					cell-matrix adhesion	extracellular region	calcium ion binding			upper_aerodigestive_tract(1)	1						GGGCCTGGACCCTGTGCGGCC	0.761													6	10					0	0	0.00116845	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44805846	44805846	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:44805846C>T	uc003tlr.2	+	17	2449	c.2326C>T	c.(2326-2328)CCG>TCG	p.P776S	ZMIZ2_uc003tlq.2_Missense_Mutation_p.P718S|ZMIZ2_uc003tls.2_Missense_Mutation_p.P750S|ZMIZ2_uc003tlt.2_Missense_Mutation_p.P399S|ZMIZ2_uc010kyj.2_Missense_Mutation_p.P298S|ZMIZ2_uc003tlu.2_Missense_Mutation_p.P57S|ZMIZ2_uc010kyk.1_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	776	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						TGAGTTCACCCCGGGACCACC	0.622													23	33					0	0	0.000229342	0	0
EGFR	1956	broad.mit.edu	37	7	55214303	55214303	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:55214303C>T	uc003tqk.2	+	4	675	c.429C>T	c.(427-429)ATC>ATT	p.I143I	EGFR_uc003tqh.2_Silent_p.I143I|EGFR_uc003tqi.2_Silent_p.I143I|EGFR_uc003tqj.2_Silent_p.I143I|EGFR_uc010kzg.1_Intron|EGFR_uc011kco.1_Silent_p.I90I	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	143	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCGCAGAAATCCTGCATGGCG	0.517		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			5	41					0	0	0.00116845	0	0
ZNF679	168417	broad.mit.edu	37	7	63726529	63726529	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:63726529G>A	uc003tsx.2	+	5	787	c.518G>A	c.(517-519)AGA>AAA	p.R173K		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	173	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AATTCCAATAGACATAAGACA	0.303													5	6					0	0	0.000602214	0	0
SPDYE7P	441251	broad.mit.edu	37	7	72338388	72338388	+	RNA	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:72338388C>G	uc010lal.1	-	1		c.1268G>C				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						GTGTGCCTCCCGGGGGGAAGT	0.567													3	67					0	0	6.4e-05	0	0
PCLO	27445	broad.mit.edu	37	7	82581603	82581603	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:82581603G>A	uc003uhx.2	-	5	8955	c.8666C>T	c.(8665-8667)TCC>TTC	p.S2889F	PCLO_uc003uhv.2_Missense_Mutation_p.S2889F|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2820					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GATTCCCTGGGATACGGTGCT	0.463													49	111					0	0	0.000781405	0	0
GRM3	2913	broad.mit.edu	37	7	86394591	86394591	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:86394591C>T	uc003uid.2	+	2	1229	c.130C>T	c.(130-132)CTG>TTG	p.L44L	GRM3_uc010lef.2_Silent_p.L42L|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	44	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTTAGGGGGCCTGTTTCCTAT	0.413													43	95					0	0	0.00148497	0	0
GRM3	2913	broad.mit.edu	37	7	86415831	86415831	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:86415831C>T	uc003uid.2	+	3	1822	c.723C>T	c.(721-723)ATC>ATT	p.I241I	GRM3_uc010lef.2_Silent_p.I239I|GRM3_uc010leg.2_Silent_p.I113I|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	241	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ACATCTGCATCGCTACGGCGG	0.617													36	41					0	0	0.000814825	0	0
SAMD9L	219285	broad.mit.edu	37	7	92764132	92764132	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:92764132C>T	uc003umh.1	-	5	2369	c.1153G>A	c.(1153-1155)GGA>AGA	p.G385R	SAMD9L_uc003umj.1_Missense_Mutation_p.G385R|SAMD9L_uc003umi.1_Missense_Mutation_p.G385R|SAMD9L_uc010lfb.1_Missense_Mutation_p.G385R|SAMD9L_uc003umk.1_Missense_Mutation_p.G385R|SAMD9L_uc010lfc.1_Missense_Mutation_p.G385R|SAMD9L_uc010lfd.1_Missense_Mutation_p.G385R|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	385										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GCCTTCATTCCATACTCTTCT	0.393													68	180					0	0	0.000781405	0	0
TMEM130	222865	broad.mit.edu	37	7	98445738	98445738	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:98445738G>A	uc003upo.2	-	8	1438	c.1249C>T	c.(1249-1251)CGT>TGT	p.R417C	TMEM130_uc011kiq.1_Missense_Mutation_p.R386C|TMEM130_uc011kir.1_Missense_Mutation_p.R405C|TMEM130_uc003upn.2_Missense_Mutation_p.R303C	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	417	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGTTCTCACGAACAATTTCC	0.567													17	53					0	0	0.00121646	0	0
TRRAP	8295	broad.mit.edu	37	7	98601834	98601834	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:98601834G>C	uc003upp.2	+	67	10498	c.10289G>C	c.(10288-10290)GGA>GCA	p.G3430A	TRRAP_uc011kis.1_Missense_Mutation_p.G3401A|TRRAP_uc003upr.2_Missense_Mutation_p.G3136A	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3430					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCGTTCCAGGATCCATGAAG	0.383													19	194					0	0	0.00152264	0	0
ZNF394	84124	broad.mit.edu	37	7	99091810	99091810	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:99091810G>A	uc003uqs.2	-	3	1189	c.1028C>T	c.(1027-1029)TCC>TTC	p.S343F	ZNF394_uc003uqt.2_Missense_Mutation_p.S136F	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	343					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					AAAAAGGCTGGAATGATGGAA	0.473													64	73					0	0	0.000781405	0	0
TRIM4	89122	broad.mit.edu	37	7	99490188	99490188	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:99490188G>A	uc003usd.2	-	7	1231	c.1101C>T	c.(1099-1101)CCC>CCT	p.P367P	TRIM4_uc003use.2_Silent_p.P341P|TRIM4_uc011kjc.1_Silent_p.P197P	NM_033017	NP_148977	Q9C037	TRIM4_HUMAN	tripartite motif protein TRIM4 isoform alpha	367	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			ovary(1)|kidney(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				CCAGAACACAGGGTAAGTGCT	0.478													20	58					0	0	0.00121646	0	0
THAP5	168451	broad.mit.edu	37	7	108205132	108205132	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:108205132G>A	uc003vfm.2	-	3	845	c.691C>T	c.(691-693)CAT>TAT	p.H231Y	THAP5_uc003vfl.2_Missense_Mutation_p.H189Y	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	231					cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TTAGCAAGATGACTGGTAGTT	0.308													40	57					0	0	0.00170553	0	0
DOCK4	9732	broad.mit.edu	37	7	111368493	111368493	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:111368493G>A	uc003vfx.2	-	52	6007	c.5738C>T	c.(5737-5739)CCC>CTC	p.P1913L	DOCK4_uc011kml.1_Missense_Mutation_p.P794L|DOCK4_uc011kmm.1_Missense_Mutation_p.P782L|DOCK4_uc003vfw.2_Missense_Mutation_p.P1325L|DOCK4_uc003vfy.2_Missense_Mutation_p.P1958L|DOCK4_uc003vfv.2_Missense_Mutation_p.P226L	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1913	Pro-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TAGCGGGACGGGGCGCCGCAG	0.716													34	34					0	0	0.00128727	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558909	113558909	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:113558909G>A	uc010ljy.1	-	1	174	c.143C>T	c.(142-144)TCT>TTT	p.S48F		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	48					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GTCTTCAGAAGAATCAGAACC	0.373													52	69					0	0	0.000781405	0	0
SVOPL	136306	broad.mit.edu	37	7	138333801	138333801	+	Missense_Mutation	SNP	G	A	A	rs143755972	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:138333801G>A	uc011kqh.1	-	7	616	c.616C>T	c.(616-618)CGC>TGC	p.R206C	SVOPL_uc003vue.2_Missense_Mutation_p.R54C	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	206	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						GAGGCGACGCGAATGAGCCAG	0.612													17	39					0	0	0.000566183	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				65	49					0	0	0.000781405	0	0
TRY6	154754	broad.mit.edu	37	7	142480020	142480020	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:142480020C>T	uc011ksq.1	+	2	235	c.152C>T	c.(151-153)TCC>TTC	p.S51F	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_RNA|uc003wan.1_Intron|TRY6_uc011kso.1_RNA|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						TGCGGTGGCTCCCTCATCAGC	0.562													31	151					0	0	0.00058488	0	0
EPHB6	2051	broad.mit.edu	37	7	142566054	142566054	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:142566054C>T	uc011kst.1	+	14	2761	c.1974C>T	c.(1972-1974)ATC>ATT	p.I658I	EPHB6_uc011ksu.1_Silent_p.I658I|EPHB6_uc003wbs.2_Silent_p.I366I|EPHB6_uc003wbt.2_Silent_p.I132I|EPHB6_uc003wbu.2_Silent_p.I366I|EPHB6_uc003wbv.2_Silent_p.I42I	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	658	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GTCAGGCCATCCGAGAACTTG	0.562													24	55					0	0	0.000586117	0	0
TRPV6	55503	broad.mit.edu	37	7	142569553	142569553	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:142569553C>T	uc003wbx.1	-	15	2301	c.2085G>A	c.(2083-2085)TGG>TGA	p.W695*	TRPV6_uc003wbw.1_Nonsense_Mutation_p.W481*|TRPV6_uc010lou.1_Nonsense_Mutation_p.W566*	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	695	Interaction with calmodulin.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GAAGCCTTTCCCAATTGGCAC	0.577													43	55					0	0	0.000374591	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217156	150217156	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:150217156G>A	uc003whk.2	+	2	224	c.94G>A	c.(94-96)GAA>AAA	p.E32K		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	32							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTTGGAGAGGAAATCTTTGA	0.507													36	39					0	0	0.00058488	0	0
KCNH2	3757	broad.mit.edu	37	7	150647470	150647470	+	Silent	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:150647470G>T	uc003wic.2	-	9	2197	c.2184C>A	c.(2182-2184)ATC>ATA	p.I728I	KCNH2_uc003wib.2_Silent_p.I388I|KCNH2_uc011kux.1_Silent_p.I632I|KCNH2_uc003wid.2_Silent_p.I388I|KCNH2_uc003wie.2_Silent_p.I728I	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	728	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GGTGCAGGCAGATGTCAGCCT	0.647													20	62					3.7963e-18	2.14461e-17	0.00047179	1	0
KCNH2	3757	broad.mit.edu	37	7	150649877	150649877	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr7:150649877C>T	uc003wic.2	-	6	1206	c.1193G>A	c.(1192-1194)TGG>TAG	p.W398*	KCNH2_uc003wib.2_Nonsense_Mutation_p.W58*|KCNH2_uc011kux.1_Nonsense_Mutation_p.W302*|KCNH2_uc003wid.2_Nonsense_Mutation_p.W58*|KCNH2_uc003wie.2_Nonsense_Mutation_p.W398*	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	398	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CAGGATGGTCCAGCGGTGGAT	0.647													39	55					0	0	0.000509022	0	0
CSMD1	64478	broad.mit.edu	37	8	2823369	2823369	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:2823369C>T	uc011kwk.1	-	59	9601	c.9211G>A	c.(9211-9213)GAA>AAA	p.E3071K	CSMD1_uc011kwj.1_Missense_Mutation_p.E2400K|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3071	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTGACTGCTTCCATGACATAG	0.493													6	11					0	0	0.000274275	0	0
RP1L1	94137	broad.mit.edu	37	8	10469143	10469143	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:10469143C>T	uc003wtc.2	-	4	2694	c.2465G>A	c.(2464-2466)CGA>CAA	p.R822Q		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	822					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCAGTGGCTTCGGTGGGGGCC	0.701													14	21					0	0	0.000219431	0	0
MSR1	4481	broad.mit.edu	37	8	16007812	16007812	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:16007812C>T	uc003wwz.2	-	7	1105	c.907G>A	c.(907-909)GGT>AGT	p.G303S	MSR1_uc010lsu.2_Missense_Mutation_p.G321S|MSR1_uc003wxa.2_Missense_Mutation_p.G303S|MSR1_uc003wxb.2_Missense_Mutation_p.G303S|MSR1_uc011kxz.1_Missense_Mutation_p.G77S	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	303	Collagen-like.|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTTAAGACCCGGAGGACCT	0.368													10	52					0	0	0.000151284	0	0
PNMA2	10687	broad.mit.edu	37	8	26365944	26365944	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:26365944G>A	uc003xez.2	-	3	1098	c.328C>T	c.(328-330)CTA>TTA	p.L110L		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	110					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		tctttttctagaaacaggttc	0													9	44					0	0	0.000274275	0	0
NRG1	3084	broad.mit.edu	37	8	32585487	32585487	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:32585487G>A	uc003xiv.2	+	6	1040	c.523G>A	c.(523-525)GGG>AGG	p.G175R	NRG1_uc003xip.2_Missense_Mutation_p.G356R|NRG1_uc003xir.2_Missense_Mutation_p.G175R|NRG1_uc010lvl.2_Missense_Mutation_p.G158R|NRG1_uc010lvm.2_Missense_Mutation_p.G141R|NRG1_uc010lvn.2_Missense_Mutation_p.G141R|NRG1_uc003xis.2_Missense_Mutation_p.G175R|NRG1_uc011lbf.1_Missense_Mutation_p.G175R|NRG1_uc010lvo.2_Missense_Mutation_p.G175R|NRG1_uc003xiu.2_Missense_Mutation_p.G175R|NRG1_uc003xiw.2_Missense_Mutation_p.G175R|NRG1_uc003xit.2_Missense_Mutation_p.G175R|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Missense_Mutation_p.G124R|NRG1_uc010lvq.2_Missense_Mutation_p.G107R|NRG1_uc003xix.2_Missense_Mutation_p.G65R|NRG1_uc003xiy.2_Missense_Mutation_p.G230R|NRG1_uc010lvt.2_Intron|NRG1_uc011lbg.1_Missense_Mutation_p.G21R|NRG1_uc011lbh.1_Missense_Mutation_p.G21R|NRG1_uc003xiz.1_RNA|NRG1_uc003xja.2_5'UTR	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	175	Extracellular (Potential).|Ser/Thr-rich.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATCCACCACTGGGACAAGCCA	0.428													43	53					0	0	0.000781405	0	0
EYA1	2138	broad.mit.edu	37	8	72127949	72127949	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:72127949C>G	uc003xys.3	-	14	1662	c.1375G>C	c.(1375-1377)GCT>CCT	p.A459P	EYA1_uc003xyr.3_Missense_Mutation_p.A424P|EYA1_uc003xyt.3_Missense_Mutation_p.A426P|EYA1_uc010lzf.2_Missense_Mutation_p.A386P|EYA1_uc003xyu.2_Missense_Mutation_p.A459P|EYA1_uc011lfe.1_Missense_Mutation_p.A453P|EYA1_uc003xyv.2_Missense_Mutation_p.A337P	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	459					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TCCCTCTTAGCTGGACCAAGC	0.473													7	26					0	0	8.12818e-05	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768012	77768012	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:77768012G>A	uc003yav.2	+	10	9107	c.8720G>A	c.(8719-8721)CGA>CAA	p.R2907Q	ZFHX4_uc003yau.1_Missense_Mutation_p.R2952Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.R2907Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2907	Homeobox 4.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGACTACCGAACTCCAACC	0.448										HNSCC(33;0.089)			8	46					0	0	0.000442599	0	0
RIMS2	9699	broad.mit.edu	37	8	104778587	104778587	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:104778587G>A	uc003ylp.2	+	3	659	c.520G>A	c.(520-522)GAG>AAG	p.E174K		NM_001100117	NP_001093587	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	205					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAGAAATGAGGAGGCACCTCA	0.443										HNSCC(12;0.0054)			6	48					0	0	8.12818e-05	0	0
RIMS2	9699	broad.mit.edu	37	8	105263362	105263362	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:105263362G>A	uc003yls.2	+	27	4097	c.3856G>A	c.(3856-3858)GAA>AAA	p.E1286K	RIMS2_uc003ylp.2_Missense_Mutation_p.E1268K|RIMS2_uc003ylw.2_Missense_Mutation_p.E1275K|RIMS2_uc003ylq.2_Missense_Mutation_p.E1082K|RIMS2_uc003ylr.2_Missense_Mutation_p.E1107K	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1330	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATTATCTTTCGAAGAGAGTCC	0.368										HNSCC(12;0.0054)			13	17					0	0	0.000219431	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815088	106815088	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:106815088C>T	uc003ymd.2	+	8	2801	c.2778C>T	c.(2776-2778)TCC>TCT	p.S926S	ZFPM2_uc011lhs.1_Silent_p.S657S	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	926					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGCAGCCTTCCCCCAATGGAA	0.428													8	22					0	0	0.000157383	0	0
OXR1	55074	broad.mit.edu	37	8	107751735	107751735	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:107751735C>T	uc011lht.1	+	12	2189	c.2090C>T	c.(2089-2091)GCA>GTA	p.A697V	OXR1_uc003ymf.2_Missense_Mutation_p.A669V|OXR1_uc011lhu.1_Missense_Mutation_p.A662V|OXR1_uc010mcg.2_RNA|OXR1_uc010mch.2_Intron|OXR1_uc003ymk.2_Missense_Mutation_p.A66V|OXR1_uc003yml.2_Missense_Mutation_p.A39V	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	697					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ACAGTGAAAGCAGACCTGGAG	0.378													22	41					0	0	0.000586117	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457651	110457651	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:110457651C>T	uc003yne.2	+	38	5657	c.5553C>T	c.(5551-5553)ATC>ATT	p.I1851I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1851	Extracellular (Potential).|IPT/TIG 11.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CACTGGTGATCACAGGAAATG	0.488										HNSCC(38;0.096)			8	23					0	0	0.000442599	0	0
KCNV1	27012	broad.mit.edu	37	8	110984881	110984881	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:110984881G>A	uc003ynr.3	-	2	939	c.597C>T	c.(595-597)ATC>ATT	p.I199I	KCNV1_uc010mcw.2_Silent_p.I199I	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	199	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GTTTCTCCAGGATATTCCAGA	0.498													14	43					0	0	0.000151284	0	0
EXT1	2131	broad.mit.edu	37	8	118831999	118831999	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:118831999G>A	uc003yok.1	-	6	2225	c.1452C>T	c.(1450-1452)ATC>ATT	p.I484I		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	484	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TCACCGCATGGATGACTGCAG	0.517			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				42	43					0	0	0.000781405	0	0
WISP1	8840	broad.mit.edu	37	8	134239797	134239797	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:134239797G>A	uc003yub.2	+	5	1024	c.948G>A	c.(946-948)AAG>AAA	p.K316K	WISP1_uc003yuc.2_Silent_p.K229K|WISP1_uc010meb.2_Silent_p.K144K|WISP1_uc010mec.2_3'UTR|WISP1_uc010med.2_Silent_p.K71K|WISP1_uc003yud.2_RNA	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	316	CTCK.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ACAAGTCTAAGACTATCGACG	0.517													37	52					0	0	0.000374591	0	0
COL22A1	169044	broad.mit.edu	37	8	139833411	139833411	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:139833411C>T	uc003yvd.2	-	7	1660	c.1213G>A	c.(1213-1215)GGC>AGC	p.G405S		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	405	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGGCGCTTGCCAATCACAGTC	0.597										HNSCC(7;0.00092)			9	24					0	0	0.000978159	0	0
GML	2765	broad.mit.edu	37	8	143927990	143927990	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:143927990G>A	uc003yxg.2	+	4	451	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	121	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TCTTGAAAGGGACATGTTACC	0.438													27	39					0	0	0.000339439	0	0
PLEC	5339	broad.mit.edu	37	8	144997805	144997805	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:144997805C>A	uc003zaf.1	-	31	6873	c.6703G>T	c.(6703-6705)GTG>TTG	p.V2235L	PLEC_uc003zab.1_Missense_Mutation_p.V2098L|PLEC_uc003zac.1_Missense_Mutation_p.V2102L|PLEC_uc003zad.2_Missense_Mutation_p.V2098L|PLEC_uc003zae.1_Missense_Mutation_p.V2066L|PLEC_uc003zag.1_Missense_Mutation_p.V2076L|PLEC_uc003zah.2_Missense_Mutation_p.V2084L|PLEC_uc003zaj.2_Missense_Mutation_p.V2125L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2235	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						TCCGCCTGCACCCGGGCCTCC	0.667													5	15					0.00116845	0.00641743	0.00116845	1	0
KIAA0020	9933	broad.mit.edu	37	9	2837296	2837296	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:2837296T>C	uc003zhp.1	-	3	284	c.188A>G	c.(187-189)AAG>AGG	p.K63R	KIAA0020_uc010mhc.1_Missense_Mutation_p.K62R|KIAA0020_uc003zhq.1_Missense_Mutation_p.K63R	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	63						endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		CTTTACACCCTTTTTCCCAAG	0.388													5	182					0	0	0.000602214	0	0
FAM154A	158297	broad.mit.edu	37	9	18928465	18928465	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:18928465G>A	uc003zni.1	-	4	1288	c.1010C>T	c.(1009-1011)TCT>TTT	p.S337F	FAM154A_uc010mip.1_Missense_Mutation_p.S145F	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	337										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		GGTGGTGGAAGAGCCTTCAAA	0.592													34	28					0	0	0.00111076	0	0
KIAA1797	54914	broad.mit.edu	37	9	20990133	20990133	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:20990133C>T	uc003zog.1	+	44	5379	c.5016C>T	c.(5014-5016)TTC>TTT	p.F1672F	KIAA1797_uc003zoh.1_Silent_p.F1108F	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1672						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CTTTGGACTTCTTCTTGCTGA	0.478													40	21					0	0	0.000781405	0	0
PIGO	84720	broad.mit.edu	37	9	35095429	35095429	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:35095429G>A	uc003zwd.2	-	2	530	c.134C>T	c.(133-135)CCA>CTA	p.P45L	PIGO_uc003zwc.1_Missense_Mutation_p.P45L|PIGO_uc003zwe.2_Missense_Mutation_p.P45L|PIGO_uc003zwf.2_Missense_Mutation_p.P45L|PIGO_uc003zwg.1_5'UTR	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	45					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCCAGGGCCTGGGGGCTCTTG	0.607													20	6					0	0	0.000295444	0	0
C9orf79	286234	broad.mit.edu	37	9	90499972	90499972	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:90499972C>T	uc004app.3	+	4	605	c.570C>T	c.(568-570)TCC>TCT	p.S190S	C9orf79_uc004apo.1_Intron	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	190	Pro-rich.					integral to membrane				ovary(3)	3						CCAGCTTGTCCCCACCAGCTC	0.627													26	24					0	0	0.00106085	0	0
TMOD1	7111	broad.mit.edu	37	9	100361935	100361935	+	Silent	SNP	G	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:100361935G>T	uc004axk.1	+	10	1248	c.1035G>T	c.(1033-1035)GCG>GCT	p.A345A	TMOD1_uc004axl.1_Silent_p.A345A	NM_003275	NP_003266	P28289	TMOD1_HUMAN	tropomodulin 1	345					muscle filament sliding	cytosol	actin binding				0		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		GGAGGCTTGCGGACCTGACTG	0.522											OREG0019346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	45					0.000602214	0.00332808	0.000602214	1	0
GRIN3A	116443	broad.mit.edu	37	9	104340091	104340091	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:104340091C>T	uc004bbp.1	-	8	3568	c.2967G>A	c.(2965-2967)GAG>GAA	p.E989E	GRIN3A_uc004bbo.1_Silent_p.E64E|GRIN3A_uc004bbq.1_Silent_p.E989E	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	989	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCTGCTTTTCCTCTATAAATG	0.358													59	29					0	0	0.000781405	0	0
GRIN3A	116443	broad.mit.edu	37	9	104448967	104448967	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:104448967C>T	uc004bbp.1	-	2	1816	c.1215G>A	c.(1213-1215)ATG>ATA	p.M405I	GRIN3A_uc004bbq.1_Missense_Mutation_p.M405I	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	405	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CTGGTTGGATCATGGTGGCTG	0.463													53	20					0	0	0.000781405	0	0
CYLC2	1539	broad.mit.edu	37	9	105767007	105767007	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:105767007C>T	uc004bbs.2	+	4	281	c.211C>T	c.(211-213)CGT>TGT	p.R71C		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	71	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				AAGAGGAGATCGTAGACAACC	0.363													22	15					0	0	0.000586117	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111936842	111936842	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:111936842C>T	uc004bdz.1	-	26	2990	c.2695G>A	c.(2695-2697)GAA>AAA	p.E899K		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	899				E -> R (in Ref. 1; AAG43366).		cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TTTCACAGTTCGGTCATCAAC	0.458													11	40					0	0	0.000978159	0	0
HDHD3	81932	broad.mit.edu	37	9	116136377	116136377	+	Silent	SNP	C	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:116136377C>G	uc004bhi.1	-	2	1042	c.258G>C	c.(256-258)GCG>GCC	p.A86A	HDHD3_uc004bhj.2_Silent_p.A86A|HDHD3_uc004bhk.2_Silent_p.A86A	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	86							phosphoglycolate phosphatase activity|protein binding				0						CCTGGACACCCGCCAGGTGGA	0.617													3	62					0	0	0.00024832	0	0
TLR4	7099	broad.mit.edu	37	9	120476725	120476725	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:120476725G>A	uc004bjz.2	+	3	2610	c.2319G>A	c.(2317-2319)AAG>AAA	p.K773K	TLR4_uc004bka.2_Silent_p.K733K|TLR4_uc004bkb.2_Silent_p.K573K	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	773	Cytoplasmic (Potential).|TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TCCTGCAGAAGGTGGAGAAGA	0.542													11	52					0	0	0.000673444	0	0
DBC1	1620	broad.mit.edu	37	9	121976304	121976304	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:121976304T>A	uc004bkc.2	-	6	1271	c.815A>T	c.(814-816)GAG>GTG	p.E272V	DBC1_uc004bkd.2_Missense_Mutation_p.E272V	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	272					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CTGCGGAAACTCCTCGGCACA	0.557													10	78					0	0	0.000673444	0	0
TRAF1	7185	broad.mit.edu	37	9	123675942	123675942	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:123675942C>T	uc004bku.1	-	5	941	c.369G>A	c.(367-369)ATG>ATA	p.M123I	TRAF1_uc011lyg.1_Missense_Mutation_p.M1I|TRAF1_uc010mvl.1_Missense_Mutation_p.M123I	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	123					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3						TCCACTGTTTCATGAACCCCA	0.612													22	25					0	0	0.000295444	0	0
MORN5	254956	broad.mit.edu	37	9	124936831	124936831	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:124936831G>A	uc004blw.2	+	4	426	c.364G>A	c.(364-366)GAT>AAT	p.D122N	MORN5_uc011lyn.1_Missense_Mutation_p.D122N|MORN5_uc011lyo.1_Silent_p.T84T	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	MORN repeat containing 5	122											0						GGGCTATTACGATTGTGGAGA	0.463													12	56					0	0	0.000978159	0	0
CRB2	286204	broad.mit.edu	37	9	126125453	126125453	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:126125453C>T	uc004bnx.1	+	2	496	c.404C>T	c.(403-405)CCC>CTC	p.P135L	CRB2_uc004bnw.1_Missense_Mutation_p.P135L	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	135	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						TGCCATTGCCCCCTTGGCTAT	0.622													4	14					0	0	0.00024832	0	0
ENG	2022	broad.mit.edu	37	9	130587562	130587562	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:130587562C>T	uc004bsj.3	-	6	1177	c.764G>A	c.(763-765)GGT>GAT	p.G255D	ENG_uc011mam.1_Missense_Mutation_p.G66D|ENG_uc004bsk.3_Missense_Mutation_p.G255D	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	255	Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						GTAGGGGGGACCCTGCAGGAT	0.632									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				15	14					0	0	0.000566183	0	0
KCNT1	57582	broad.mit.edu	37	9	138676458	138676458	+	Silent	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:138676458C>T	uc011mdq.1	+	26	3095	c.3021C>T	c.(3019-3021)CTC>CTT	p.L1007L	KCNT1_uc011mdr.1_Silent_p.L834L|KCNT1_uc010nbf.2_Silent_p.L962L|KCNT1_uc004cgo.1_Silent_p.L756L	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	1007						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CGGGGTACCTCTGTGCCGTAA	0.617													13	6					0	0	0.00136819	0	0
MAMDC4	158056	broad.mit.edu	37	9	139754341	139754341	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:139754341A>C	uc004cjs.2	+	26	3247	c.3197A>C	c.(3196-3198)AAC>ACC	p.N1066T	MAMDC4_uc011mej.1_Missense_Mutation_p.N403T	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	1145	Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCCACAGGGAACACAGCCGCA	0.652													6	27					0	0	0.000157383	0	0
ABCA2	20	broad.mit.edu	37	9	139903069	139903069	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr9:139903069G>A	uc011mem.1	-	47	7219	c.7071C>T	c.(7069-7071)TTC>TTT	p.F2357F	ABCA2_uc011mel.1_Silent_p.F2358F|ABCA2_uc004ckl.1_Silent_p.F2288F|ABCA2_uc004ckm.1_Silent_p.F2388F	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	2357					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CAAAGTTCACGAACACCTGGT	0.682													13	7					0	0	0.00136819	0	0
CSF2RA	1438	broad.mit.edu	37	X	1407513	1407513	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:1407513G>A	uc010nct.2	+	6	643	c.321G>A	c.(319-321)CAG>CAA	p.Q107Q	CSF2RA_uc011mhb.1_Silent_p.Q107Q|CSF2RA_uc004cpq.2_Silent_p.Q107Q|CSF2RA_uc004cpn.2_Silent_p.Q107Q|CSF2RA_uc004cpo.2_Silent_p.Q107Q|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_5'UTR|CSF2RA_uc004cpp.2_Silent_p.Q107Q|CSF2RA_uc010ncv.2_Silent_p.Q107Q|CSF2RA_uc004cpr.2_Silent_p.Q107Q	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	107	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GATTTCAACAGAAACTGCTTT	0.453													96	91					0	0	0.000781405	0	0
PHKA2	5256	broad.mit.edu	37	X	18958111	18958111	+	Splice_Site	SNP	A	G	G			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:18958111A>G	uc004cyv.3	-	9	1348	c.918_splice	c.e9+1	p.E306_splice		NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)						glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TTTAAATACAACCTCTCTTGG	0.353													72	30					0	0	0.000781405	0	0
CNKSR2	22866	broad.mit.edu	37	X	21613508	21613508	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:21613508G>A	uc004czx.1	+	17	2007	c.1971G>A	c.(1969-1971)ATG>ATA	p.M657I	CNKSR2_uc004czw.2_Missense_Mutation_p.M657I|CNKSR2_uc011mjn.1_Missense_Mutation_p.M608I|CNKSR2_uc011mjo.1_Missense_Mutation_p.M627I|CNKSR2_uc004czy.2_Missense_Mutation_p.M249I	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	657	PH.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						TTGATGATATGAACAGGTAAA	0.323													32	12					0	0	0.000491102	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157408	26157408	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:26157408G>A	uc004dbq.1	+	2	493	c.306G>A	c.(304-306)TGG>TGA	p.W102*		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	102							protein binding			central_nervous_system(1)	1						CTGAGGGCTGGAAAGAAGATC	0.433													10	4					0	0	0.000442599	0	0
WNK3	65267	broad.mit.edu	37	X	54263502	54263502	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:54263502G>A	uc004dtd.1	-	20	4795	c.4356C>T	c.(4354-4356)CAC>CAT	p.H1452H	WNK3_uc004dtc.1_Silent_p.H1499H	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1452					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GTTCTTCGTGGTGTGGTAAGC	0.458													76	28					0	0	0.000781405	0	0
WNK3	65267	broad.mit.edu	37	X	54263821	54263821	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:54263821G>A	uc004dtd.1	-	20	4476	c.4037C>T	c.(4036-4038)TCG>TTG	p.S1346L	WNK3_uc004dtc.1_Missense_Mutation_p.S1393L	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1346					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ATAAGAAAACGAAGTTTTTGG	0.378													50	8					0	0	0.000781405	0	0
MAGEE1	57692	broad.mit.edu	37	X	75648631	75648632	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:75648631_75648632CC>TT	uc004ecm.1	+	1	515_516	c.308_309CC>TT	c.(307-309)TCC>TTT	p.S103F		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	103						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CCTGGCACCTCCGTGCTGCCCA	0.683													11	0					0	0	6.4e-05	0	0
NRK	203447	broad.mit.edu	37	X	105153188	105153188	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:105153188G>A	uc004emd.2	+	13	1858	c.1555G>A	c.(1555-1557)GAA>AAA	p.E519K	NRK_uc010npc.1_Missense_Mutation_p.E187K	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	519	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGTACCAGAGGAATTTCAGGG	0.547										HNSCC(51;0.14)			10	3					0	0	0.000442599	0	0
RBM41	55285	broad.mit.edu	37	X	106312573	106312573	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:106312573G>A	uc004emz.2	-	6	1018	c.987C>T	c.(985-987)TTC>TTT	p.F329F	RBM41_uc004emy.1_Silent_p.F329F	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	329	RRM.						nucleotide binding|RNA binding			ovary(1)	1						GGAACCGAGCGAACAATGACA	0.418													70	35					0	0	0.000781405	0	0
COL4A5	1287	broad.mit.edu	37	X	107829912	107829912	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:107829912C>T	uc004enz.1	+	19	1302	c.1100C>T	c.(1099-1101)CCT>CTT	p.P367L	COL4A5_uc011mso.1_Missense_Mutation_p.P367L|COL4A5_uc004eob.1_5'UTR	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	367	Triple-helical region.		Missing (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CCTGGGTTGCCTGGAGAAAAA	0.413									Alport_syndrome_with_Diffuse_Leiomyomatosis				43	27					0	0	0.000509022	0	0
GRIA3	2892	broad.mit.edu	37	X	122613938	122613938	+	Silent	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:122613938G>A	uc004etq.3	+	15	2642	c.2349G>A	c.(2347-2349)TTG>TTA	p.L783L	GRIA3_uc004etr.3_Intron|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	783	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TTGCAGTATTGAAACTCAGTG	0.383													32	16					0	0	0.000953801	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995196	140995196	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:140995196G>A	uc004fbt.2	+	4	2292	c.2006G>A	c.(2005-2007)GGG>GAG	p.G669E	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	669							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTGAGGGGATGCACTCC	0.572										HNSCC(15;0.026)			62	20					0	0	0.000781405	0	0
F8	2157	broad.mit.edu	37	X	154157677	154157677	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chrX:154157677G>A	uc004fmt.2	-	14	4559	c.4388C>T	c.(4387-4389)TCT>TTT	p.S1463F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1463	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding	p.S1463P(1)		ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AATGGCTAAAGAAAGGTTATT	0.418													34	7					0	0	0.000953801	0	0
TENC1	23371	broad.mit.edu	37	12	53449380	53449380	+	Frame_Shift_Del	DEL	A	-	-			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr12:53449380delA	uc001sbp.2	+	9	737	c.602delA	c.(601-603)CATfs	p.H201fs	uc001sbk.1_5'Flank|TENC1_uc001sbl.2_Frame_Shift_Del_p.H77fs|TENC1_uc001sbm.2_Frame_Shift_Del_p.H211fs|TENC1_uc001sbn.2_Frame_Shift_Del_p.H211fs|TENC1_uc001sbo.1_Frame_Shift_Del_p.H201fs|TENC1_uc001sbq.2_5'Flank|TENC1_uc001sbr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	201	Phosphatase tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CCTGAGCTGCATGCTCCACCC	0.612													30	35	---	---	---	---					
YY1	7528	broad.mit.edu	37	14	100705788	100705790	+	In_Frame_Del	DEL	CCA	-	-			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr14:100705788_100705790delCCA	uc001ygy.1	+	1	687_689	c.207_209delCCA	c.(205-210)GGCCAC>GGC	p.H80del		NM_003403	NP_003394	P25490	TYY1_HUMAN	YY1 transcription factor	80	Poly-His.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding				0		Melanoma(154;0.152)				gGCACGCCGGccaccaccaccac	0.305													3	6	---	---	---	---					
CYP19A1	1588	broad.mit.edu	37	15	51503156	51503163	+	Frame_Shift_Del	DEL	AGTGTAAC	-	-	rs141305220	byFrequency	TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr15:51503156_51503163delAGTGTAAC	uc001zyz.3	-	11	1605_1612	c.1354_1361delGTTACACT	c.(1354-1362)GTTACACTTfs	p.V452fs	CYP19A1_uc001zza.3_Frame_Shift_Del_p.V452fs	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	452_454					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TCGTCTCAGAAGTGTAACGAGGATGGCT	0.462													22	44	---	---	---	---					
ABCA8	10351	broad.mit.edu	37	17	66871424	66871425	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr17:66871424_66871425delGA	uc002jhp.2	-	35	4666_4667	c.4487_4488delTC	c.(4486-4488)TTCfs	p.F1496fs	ABCA8_uc002jhq.2_Frame_Shift_Del_p.F1536fs|ABCA8_uc010wqq.1_Frame_Shift_Del_p.F1531fs	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1496						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CAGCCTGGGGGAAAAGCCTCAG	0.465													35	76	---	---	---	---					
ATXN1	6310	broad.mit.edu	37	6	16327864	16327865	+	In_Frame_Ins	INS	-	TGC	TGC			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr6:16327864_16327865insTGC	uc003nbt.2	-	8	1648_1649	c.677_678insGCA	c.(676-678)CAC>CAGCAC	p.225_226insQ	ATXN1_uc010jpi.2_In_Frame_Ins_p.225_226insQ|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	225_226					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CCCTGCTGAGGtgctgctgctg	0.366													4	4	---	---	---	---					
HEY1	23462	broad.mit.edu	37	8	80677926	80677927	+	In_Frame_Ins	INS	-	GTT	GTT			TCGA-DA-A1I7-06A-22D-A197-08	TCGA-DA-A1I7-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c80758ba-28fe-407c-acff-f0d3a8777bf4	443a2c82-82b4-4b1f-851c-ae271bf0b5d7	g.chr8:80677926_80677927insGTT	uc003ybm.2	-	5	611_612	c.411_412insAAC	c.(409-414)insAAC	p.137_138insN	HEY1_uc010lzq.2_In_Frame_Ins_p.18_19insN|HEY1_uc003ybl.2_In_Frame_Ins_p.141_142insN	NM_012258	NP_036390	Q9Y5J3	HEY1_HUMAN	hairy/enhancer-of-split related with YRPW motif	137_138	Orange.				angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding			lung(3)	3	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			ATGATGCTCAGATAACGCGCAA	0.530											OREG0018837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	67	---	---	---	---					
