Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD5	26038	broad.mit.edu	37	1	6206302	6206302	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:6206302C>T	uc001amb.1	-	11	1872	c.1772G>A	c.(1771-1773)TGG>TAG	p.W591*	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	591					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AATCATCATCCACTCTGGCTT	0.577000													13	58					0	0	0.000566183	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073678	8073678	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:8073678C>T	uc001aoz.2	-	4	1230	c.981G>A	c.(979-981)CCG>CCA	p.P327P	ERRFI1_uc001apa.1_Silent_p.P252P	NM_018948	NP_061821	Q9UJM3	ERRFI_HUMAN	mitogen-inducible gene 6 protein	327					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			ovary(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		GCGAGTTACTCGGTGACAAAG	0.512000													22	126					0	0	0.000586117	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887686	12887686	+	Silent	SNP	T	C	C	rs59802947	by1000genomes	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:12887686T>C	uc001auk.2	-	3	367	c.171A>G	c.(169-171)AGA>AGG	p.R57R		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	57											0						GAAGTTTCCATCTCCTGTGGG	0.468000													6	215					0	0	0.000151284	0	0
ZBTB40	9923	broad.mit.edu	37	1	22817048	22817048	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:22817048C>T	uc001bft.2	+	3	1118	c.607C>T	c.(607-609)CCA>TCA	p.P203S	ZBTB40_uc001bfu.2_Missense_Mutation_p.P203S|ZBTB40_uc009vqi.1_Missense_Mutation_p.P203S	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	203					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TGCAGAAACCCCAGCGGAGAC	0.522000													17	88					0	0	0.000422831	0	0
PIGV	55650	broad.mit.edu	37	1	27120878	27120878	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:27120878C>T	uc001bmz.2	+	3	684	c.353C>T	c.(352-354)TCG>TTG	p.S118L	PIGV_uc001bmy.2_Intron|PIGV_uc009vso.2_Missense_Mutation_p.S118L|PIGV_uc010ofg.1_Intron|PIGV_uc001bna.2_Missense_Mutation_p.S118L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	118	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CTGCTGATTTCGGTAGCATCA	0.507000													12	40					0	0	6.40141e-05	0	0
DNAJC8	22826	broad.mit.edu	37	1	28536526	28536526	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:28536526G>A	uc001bpn.2	-	5	389	c.356C>T	c.(355-357)GCC>GTC	p.A119V	DNAJC8_uc001bpo.2_RNA	NM_014280	NP_055095	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	119	J.				nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		TACATCCAGGGCCCTCTTCTT	0.428000													11	34					0	0	0.000219431	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45484180	45484180	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:45484180C>T	uc001cnd.2	-	14	3732	c.3504G>A	c.(3502-3504)CAG>CAA	p.Q1168Q		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	1168							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					CTTTGTAGATCTGTTTGAGGT	0.532000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	115					0	0	0.000295444	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45486444	45486444	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:45486444G>A	uc001cnd.2	-	12	2694	c.2466C>T	c.(2464-2466)CTC>CTT	p.L822L		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	822							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GAATTGTTCGGAGTCTCAAAG	0.423000													30	156					0	0	0.000814825	0	0
C8B	732	broad.mit.edu	37	1	57397493	57397493	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:57397493G>A	uc001cyp.2	-	11	1678	c.1611C>T	c.(1609-1611)TCC>TCT	p.S537S	C8B_uc010oon.1_Silent_p.S475S|C8B_uc010ooo.1_Silent_p.S485S	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	537					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TCTTCCGATAGGAGACCTCAC	0.512000													8	29					0	0	0.000673444	0	0
KANK4	163782	broad.mit.edu	37	1	62740493	62740493	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:62740493C>T	uc001dah.3	-	3	660	c.283G>A	c.(283-285)GTG>ATG	p.V95M	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	95										ovary(3)|skin(2)|lung(1)	6						TCCCTTGGCACCACGGGAGAC	0.607000													25	63					0	0	0.000375601	0	0
EFCAB7	84455	broad.mit.edu	37	1	64022849	64022849	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:64022849G>C	uc001dbf.2	+	10	1573	c.1279G>C	c.(1279-1281)GAA>CAA	p.E427Q		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	427	EF-hand 3.|3 (Potential).						calcium ion binding				0						TAGCCTTGAAGAATATAATTT	0.313000													3	100					0	0	6.4e-05	0	0
CACHD1	57685	broad.mit.edu	37	1	65131799	65131799	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:65131799T>C	uc001dbo.1	+	16	2288	c.2183T>C	c.(2182-2184)GTT>GCT	p.V728A	CACHD1_uc001dbp.1_Missense_Mutation_p.V483A|CACHD1_uc001dbq.1_Missense_Mutation_p.V483A|CACHD1_uc010opa.1_5'UTR	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	779	Extracellular (Potential).|Cache 2.				calcium ion transport	integral to membrane				ovary(2)	2						TACTTAGATGTTGGAGGAGCT	0.328000													9	61					0	0	0.000442599	0	0
SFRS11	9295	broad.mit.edu	37	1	70700397	70700397	+	Missense_Mutation	SNP	G	C	C	rs140006011		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:70700397G>C	uc001des.2	+	5	590	c.466G>C	c.(466-468)GCT>CCT	p.A156P	SFRS11_uc001det.2_Missense_Mutation_p.A156P|SFRS11_uc001deu.2_Missense_Mutation_p.A156P|SFRS11_uc001dev.2_5'UTR|SFRS11_uc001dew.2_Missense_Mutation_p.A96P	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	156					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TGTTCCACTGGCTGCTTTGGG	0.353000													15	101					0	0	0.00074312	0	0
AK5	26289	broad.mit.edu	37	1	77806157	77806157	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:77806157C>T	uc001dhn.2	+	6	1052	c.795C>T	c.(793-795)GAC>GAT	p.D265D	AK5_uc001dho.2_Silent_p.D239D	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	265					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						GCCGACCAGACGACAATGTAA	0.458000													11	72					0	0	6.40141e-05	0	0
NEXN	91624	broad.mit.edu	37	1	78383922	78383922	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:78383922G>A	uc001dic.3	+	5	708	c.411G>A	c.(409-411)AGG>AGA	p.R137R	NEXN_uc001dia.3_Silent_p.R137R|NEXN_uc009wcb.1_Silent_p.R73R|NEXN_uc001dib.3_Silent_p.R73R|NEXN_uc001did.1_Silent_p.R61R|NEXN_uc001dif.1_Silent_p.R29R	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	137	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		TAGAAAAGAGGAAAATACAGC	0.378000													7	44					0	0	8.12818e-05	0	0
ABCD3	5825	broad.mit.edu	37	1	94953463	94953464	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:94953463_94953464GG>AA	uc001dqn.3	+	13	1183_1184	c.1081_1082GG>AA	c.(1081-1083)GGA>AAA	p.G361K	ABCD3_uc010oto.1_Missense_Mutation_p.G385K|ABCD3_uc010otp.1_Missense_Mutation_p.G288K|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.G49K	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	361	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CTACCAAAGTGGAAGAATGCTT	0.327000													9	47					0	0	6.4e-05	0	0
SARS	6301	broad.mit.edu	37	1	109777939	109777939	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:109777939C>T	uc001dwu.1	+	7	930	c.855C>T	c.(853-855)CTC>CTT	p.L285L	SARS_uc001dwt.1_Silent_p.L285L|SARS_uc001dwv.1_Silent_p.L285L|SARS_uc001dww.1_Silent_p.L218L|SARS_uc001dwx.1_Silent_p.L237L|SARS_uc009wfa.1_Silent_p.L285L|SARS_uc001dwy.1_Silent_p.L110L|SARS_uc001dwz.1_Silent_p.L110L	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	285					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	ATGAGTGGCTCCGGCCGGAGG	0.592000													64	412					0	0	0.000781405	0	0
ADORA3	140	broad.mit.edu	37	1	112043095	112043095	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:112043095G>A	uc001ebh.3	-	2	1201	c.434C>T	c.(433-435)CCC>CTC	p.P145L	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Intron	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	145	Helical; Name=4; (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GCCAAACATGGGGGTCAATCC	0.483000													18	89					0	0	0.000958276	0	0
MAGI3	260425	broad.mit.edu	37	1	114165587	114165587	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:114165587C>T	uc001edk.2	+	9	1512	c.1331C>T	c.(1330-1332)CCC>CTC	p.P444L	MAGI3_uc001edh.3_Missense_Mutation_p.P469L|MAGI3_uc001edi.3_Missense_Mutation_p.P444L|MAGI3_uc010owm.1_Missense_Mutation_p.P469L|MAGI3_uc001edj.2_Missense_Mutation_p.P165L	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	469	Interaction with PTEN.|PDZ 2.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAGATGGTCCCGCAGCTCAG	0.343000													4	29					0	0	0.00024832	0	0
MAGI3	260425	broad.mit.edu	37	1	114189223	114189223	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:114189223C>T	uc001edk.2	+	12	2295	c.2114C>T	c.(2113-2115)TCT>TTT	p.S705F	MAGI3_uc001edh.3_Missense_Mutation_p.S730F|MAGI3_uc001edi.3_Missense_Mutation_p.S705F|MAGI3_uc010owm.1_Missense_Mutation_p.S730F|MAGI3_uc001edj.2_Missense_Mutation_p.S426F	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	730					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGGATCCTTCTGAGGTCTAC	0.378000													14	60					0	0	0.000422831	0	0
DENND2C	163259	broad.mit.edu	37	1	115144803	115144803	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:115144803G>A	uc001efd.1	-	12	2382	c.1680C>T	c.(1678-1680)TCC>TCT	p.S560S	DENND2C_uc001eez.2_RNA|DENND2C_uc001efc.1_Silent_p.S503S	NM_198459	NP_940861	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	560	UDENN.									skin(3)	3	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCAAGACAAAGGAGAATGTTT	0.388000													6	47					0	0	3.59834e-05	0	0
RPRD2	23248	broad.mit.edu	37	1	150444095	150444095	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:150444095C>T	uc009wlr.2	+	11	2872	c.2671C>T	c.(2671-2673)CCA>TCA	p.P891S	RPRD2_uc010pcc.1_Missense_Mutation_p.P865S|RPRD2_uc001eup.3_Missense_Mutation_p.P865S	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	891	Ser-rich.						protein binding			ovary(1)	1						TGCCTTCCCTCCATCTGTAAG	0.517000													12	67					0	0	6.40141e-05	0	0
LASS2	29956	broad.mit.edu	37	1	150941453	150941453	+	Silent	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:150941453A>G	uc001evy.2	-	2	501	c.114T>C	c.(112-114)GAT>GAC	p.D38D	LASS2_uc001evz.2_Silent_p.D38D|LASS2_uc009wmh.2_Intron	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	38	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGATATAGAGATCTGAGGCTT	0.532000													8	82					0	0	0.000274275	0	0
SELENBP1	8991	broad.mit.edu	37	1	151338884	151338884	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:151338884T>C	uc001exx.2	-	7	757	c.710A>G	c.(709-711)GAG>GGG	p.E237G	SELENBP1_uc010pcy.1_Missense_Mutation_p.E279G|SELENBP1_uc001exy.2_Missense_Mutation_p.E134G|SELENBP1_uc001exz.2_Missense_Mutation_p.E134G|SELENBP1_uc010pcz.1_Missense_Mutation_p.E175G|SELENBP1_uc009wms.2_Missense_Mutation_p.E73G|SELENBP1_uc009wmt.2_Missense_Mutation_p.E134G|SELENBP1_uc001eya.2_Missense_Mutation_p.E173G|SELENBP1_uc009wmu.2_Missense_Mutation_p.E134G	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	237					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTGCACAATCTCATGGCGCTG	0.577000													15	94					0	0	0.000422831	0	0
TCHH	7062	broad.mit.edu	37	1	152082565	152082565	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:152082565A>C	uc001ezp.2	-	2	3128	c.3128T>G	c.(3127-3129)CTC>CGC	p.L1043R	TCHH_uc009wne.1_Missense_Mutation_p.L1043R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1043	10 X 30 AA tandem repeats.|4-5.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGCTCCTGGAGTCTTCTTTT	0.254000													4	62					0	0	0.00024832	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153312982	153312982	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:153312982C>T	uc001fbo.2	-	7	764	c.699G>A	c.(697-699)GCG>GCA	p.A233A	PGLYRP4_uc001fbp.2_Silent_p.A229A	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	233					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCCATACTTCGCTGGGAGAG	0.597000													6	28					0	0	8.12818e-05	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156914849	156914849	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:156914849G>A	uc001fqo.2	-	29	3873	c.2833C>T	c.(2833-2835)CTG>TTG	p.L945L	ARHGEF11_uc010phu.1_Silent_p.L361L|ARHGEF11_uc001fqn.2_Silent_p.L985L	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	945					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCCTCTCCAGGGCGGTGGCA	0.567000													8	131					0	0	0.000442599	0	0
ETV3L	440695	broad.mit.edu	37	1	157068567	157068567	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:157068567G>A	uc001fqq.1	-	3	702	c.417C>T	c.(415-417)TCC>TCT	p.S139S		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	139						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GCAAGTGGGGGGATGGCGGCG	0.602000													4	46					0	0	0.00024832	0	0
POU2F1	5451	broad.mit.edu	37	1	167341234	167341234	+	Silent	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:167341234C>G	uc001gec.2	+	6	456	c.294C>G	c.(292-294)CCC>CCG	p.P98P	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Silent_p.P96P|POU2F1_uc001gee.2_Silent_p.P98P|POU2F1_uc010plh.1_Silent_p.P98P|POU2F1_uc001gef.2_Silent_p.P110P|POU2F1_uc001geg.2_5'UTR	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	98					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						CAGCCATTCCCCAGACCCAGC	0.507000													4	161					0	0	0.00024832	0	0
RGS21	431704	broad.mit.edu	37	1	192335244	192335244	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:192335244C>T	uc001gsh.2	+	5	623	c.449C>T	c.(448-450)CCT>CTT	p.P150L		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	150					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						AAATGGCTCCCTTTTTTGTGA	0.333000													11	33					0	0	6.40141e-05	0	0
KIF14	9928	broad.mit.edu	37	1	200522523	200522523	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:200522523C>T	uc010ppk.1	-	30	5379	c.4940G>A	c.(4939-4941)TGG>TAG	p.W1647*	KIF14_uc010ppj.1_Nonsense_Mutation_p.W1156*	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1647	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TATTCACACCCACTGAATCCT	0.448000													16	110					0	0	0.000958276	0	0
C1orf116	79098	broad.mit.edu	37	1	207196511	207196511	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:207196511G>A	uc001hfd.2	-	4	857	c.598C>T	c.(598-600)CCG>TCG	p.P200S	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	200						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					GCTTCTGGCGGAGGGATGAGC	0.657000													14	95					0	0	0.000151284	0	0
MIA3	375056	broad.mit.edu	37	1	222803033	222803033	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:222803033C>A	uc001hnl.2	+	4	2480	c.2471C>A	c.(2470-2472)CCA>CAA	p.P824Q	MIA3_uc009xea.1_Missense_Mutation_p.P660Q	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	824	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		GCACAGAGACCATTTGAACGA	0.423000													11	400					0.000673444	0.00844079	0.000673444	1	0
AKT3	10000	broad.mit.edu	37	1	243828126	243828126	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:243828126G>T	uc001iab.1	-	3	313	c.232C>A	c.(232-234)CAG>AAG	p.Q78K	AKT3_uc001hzz.1_Missense_Mutation_p.Q78K	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	78	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			GTAGTCCACTGGAGACATCTG	0.308000													7	73					6.42651e-13	8.29488e-12	6.40141e-05	1	0
OR2M3	127062	broad.mit.edu	37	1	248366886	248366886	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr1:248366886G>A	uc010pzg.1	+	1	517	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGGTCTCGGGAAATAGCCCA	0.418000													25	108					0	0	0.00047179	0	0
ARMC4	55130	broad.mit.edu	37	10	28225794	28225794	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:28225794C>T	uc009xky.2	-	15	2211	c.2113G>A	c.(2113-2115)GAA>AAA	p.E705K	ARMC4_uc010qds.1_Missense_Mutation_p.E230K|ARMC4_uc010qdt.1_Missense_Mutation_p.E397K|ARMC4_uc001itz.2_Missense_Mutation_p.E705K	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	705							binding			ovary(4)|skin(2)	6						TCCCGGGTTTCCTTATCTTCA	0.488000													12	49					0	0	0.000151284	0	0
Unknown	0	broad.mit.edu	37	10	44983870	44983870	+	RNA	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:44983870C>T	uc001jbj.1	-	1		c.21G>A								Homo sapiens map t(4;11)(q21;p15) NUP98-RAP1GDS1 fusion protein type 1 (NRG) mRNA, partial cds.																		TCAGCTTCTTCAAGGTATCAC	0.532000													7	26					0	0	8.12818e-05	0	0
LOC642826	642826	broad.mit.edu	37	10	47193377	47193377	+	RNA	SNP	T	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:47193377T>C	uc001jei.2	-	16		c.2140A>G			uc009xnf.2_Missense_Mutation_p.M248V					Homo sapiens cDNA, FLJ99065.												0						GACCAGCGCATGGACAGCTTG	0.582000													4	12					0	0	8.12818e-05	0	0
MYST4	23522	broad.mit.edu	37	10	76729810	76729810	+	Silent	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:76729810A>G	uc001jwn.1	+	6	1372	c.879A>G	c.(877-879)AGA>AGG	p.R293R	MYST4_uc001jwm.1_Silent_p.R293R|MYST4_uc001jwo.1_Silent_p.R293R|MYST4_uc001jwp.1_Silent_p.R293R	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	293	PHD-type 2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					CCTGTGATAGAGGATTTCATA	0.323000			T	CREBBP	AML								10	32					0	0	0.000673444	0	0
IFIT1B	439996	broad.mit.edu	37	10	91144016	91144016	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:91144016G>A	uc001kgh.2	+	2	1026	c.946G>A	c.(946-948)GAA>AAA	p.E316K	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron	NM_001010987	NP_001010987	Q5T764	IFT1B_HUMAN	interferon-induced protein with	316							binding				0						GCAAGATAGGGAAACTGTGGA	0.438000													8	54					0	0	0.000157383	0	0
SLIT1	6585	broad.mit.edu	37	10	98762108	98762108	+	Silent	SNP	G	A	A	rs146064836	byFrequency	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:98762108G>A	uc001kmw.2	-	36	4425	c.4173C>T	c.(4171-4173)TGC>TGT	p.C1391C		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1391	EGF-like 8.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		CGAGGGGCACGCATTGCCCAT	0.493000													4	10					0	0	0.00024832	0	0
FGFR2	2263	broad.mit.edu	37	10	123298196	123298196	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:123298196T>A	uc010qtk.1	-	6	1305	c.658A>T	c.(658-660)AGT>TGT	p.S220C	FGFR2_uc010qtg.1_Missense_Mutation_p.S220C|FGFR2_uc010qth.1_Missense_Mutation_p.S105C|FGFR2_uc010qti.1_Missense_Mutation_p.S131C|FGFR2_uc010qtj.1_Missense_Mutation_p.S220C|FGFR2_uc010qtl.1_Missense_Mutation_p.S220C|FGFR2_uc010qtm.1_Missense_Mutation_p.S105C|FGFR2_uc001lfl.3_Missense_Mutation_p.S220C|FGFR2_uc001lfm.2_Missense_Mutation_p.S131C|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Missense_Mutation_p.S239C|FGFR2_uc010qto.1_Missense_Mutation_p.S124C|FGFR2_uc001lfo.1_Missense_Mutation_p.S239C|FGFR2_uc010qtp.1_Missense_Mutation_p.S239C|FGFR2_uc010qtq.1_Missense_Mutation_p.S239C	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	220	Ig-like C2-type 2.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GGGACCACACTTTCCATAATG	0.448000		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				7	34					0	0	0.000157383	0	0
UROS	7390	broad.mit.edu	37	10	127486659	127486659	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr10:127486659G>A	uc001liw.3	-	6	583	c.450C>T	c.(448-450)ATC>ATT	p.I150I	UROS_uc001liv.3_Missense_Mutation_p.S30F|UROS_uc010quh.1_RNA|UROS_uc001lix.3_Silent_p.I150I|UROS_uc001liy.3_RNA	NM_000375	NP_000366	P10746	HEM4_HUMAN	uroporphyrinogen III synthase	150					heme biosynthetic process|uroporphyrinogen III biosynthetic process	cytosol|mitochondrion	uroporphyrinogen-III synthase activity				0		all_lung(145;0.00756)|Lung NSC(174;0.0116)|Colorectal(57;0.0855)|all_neural(114;0.0937)|Breast(234;0.203)				CTTTTGGCAGGATTTCTCTTT	0.493000													8	42					0	0	6.40141e-05	0	0
PHRF1	57661	broad.mit.edu	37	11	587263	587263	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:587263C>T	uc001lqe.2	+	4	350	c.219C>T	c.(217-219)TCC>TCT	p.S73S	PHRF1_uc010qwc.1_Silent_p.S73S|PHRF1_uc010qwd.1_Silent_p.S72S|PHRF1_uc010qwe.1_Silent_p.S69S	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	73							RNA polymerase binding|zinc ion binding				0						CTCCAGGTTCCGAGGATTCTG	0.597000													4	13					0	0	0.000602214	0	0
OR51A4	401666	broad.mit.edu	37	11	4967467	4967467	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:4967467C>T	uc010qys.1	-	1	864	c.864G>A	c.(862-864)ACG>ACA	p.T288T		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAATTGGGTTCGTCAGTGGAG	0.428000													9	140					0	0	0.000442599	0	0
OR51B5	282763	broad.mit.edu	37	11	5363896	5363896	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:5363896G>A	uc001map.1	-	1	859	c.859C>T	c.(859-861)CCT>TCT	p.P287S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATGTTATAGGATTCATTAGT	0.393000													5	49					0	0	3.59834e-05	0	0
OR51M1	390059	broad.mit.edu	37	11	5410752	5410752	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:5410752C>T	uc010qzc.1	+	1	124	c.124C>T	c.(124-126)CCC>TCC	p.P42S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	42						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GATTTTCATCCCCTTTTTCTT	0.413000													6	99					0	0	3.59834e-05	0	0
SOX6	55553	broad.mit.edu	37	11	16010675	16010675	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:16010675G>C	uc001mme.2	-	14	1906	c.1873C>G	c.(1873-1875)CGC>GGC	p.R625G	SOX6_uc001mmd.2_Missense_Mutation_p.R588G|SOX6_uc001mmf.2_Missense_Mutation_p.R585G|SOX6_uc001mmg.2_Missense_Mutation_p.R592G	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	612					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity	p.R592C(1)		ovary(3)	3						GCACGGCCGCGGGCGTCCCTG	0.522000											OREG0020800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	145					0	0	3.59834e-05	0	0
ABCC8	6833	broad.mit.edu	37	11	17450174	17450174	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:17450174C>T	uc001mnc.2	-	13	1987	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	621	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CACTGCTCCTCACGGATCTCT	0.652000													14	93					0	0	0.000566183	0	0
SAA1	6288	broad.mit.edu	37	11	18290771	18290771	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:18290771G>A	uc010rda.1	+	3	344	c.121G>A	c.(121-123)GAC>AAC	p.D41N	SAA1_uc001moa.3_RNA|SAA1_uc010rdb.1_Missense_Mutation_p.D41N	NM_000331	NP_000322	P02735	SAA_HUMAN	serum amyloid A1 preproprotein	41					acute-phase response|elevation of cytosolic calcium ion concentration|innate immune response|lymphocyte chemotaxis|macrophage chemotaxis|negative regulation of inflammatory response|neutrophil chemotaxis|platelet activation|positive regulation of cell adhesion|positive regulation of interleukin-1 secretion	high-density lipoprotein particle	G-protein-coupled receptor binding				0					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	AGCCTACTCTGACATGAGAGA	0.527000													6	43					0	0	0.000157383	0	0
SLC6A5	9152	broad.mit.edu	37	11	20652303	20652303	+	Silent	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:20652303C>G	uc001mqd.2	+	10	1839	c.1566C>G	c.(1564-1566)TCC>TCG	p.S522S	SLC6A5_uc009yic.2_Silent_p.S287S	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	522	Helical; Name=7; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TCATCTTCTCCGTTATCGGCT	0.507000													3	73					0	0	6.4e-05	0	0
NELL1	4745	broad.mit.edu	37	11	21581772	21581772	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:21581772G>A	uc001mqe.2	+	17	1977	c.1824G>A	c.(1822-1824)TGG>TGA	p.W608*	NELL1_uc001mqf.2_Nonsense_Mutation_p.W561*|NELL1_uc009yid.2_Nonsense_Mutation_p.W636*|NELL1_uc010rdo.1_Nonsense_Mutation_p.W551*|NELL1_uc010rdp.1_Nonsense_Mutation_p.W321*|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	608	EGF-like 6; calcium-binding (Potential).				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACACCTGTTGGAACGATTCTG	0.512000													10	96					0	0	6.40141e-05	0	0
OR4C3	256144	broad.mit.edu	37	11	48346606	48346606	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:48346606C>T	uc010rhv.1	+	1	114	c.114C>T	c.(112-114)TTC>TTT	p.F38F		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CAGAATTTTTCATGCTGGGGC	0.418000													8	83					0	0	0.000157383	0	0
Unknown	0	broad.mit.edu	37	11	55063004	55063004	+	RNA	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:55063004C>T	uc001nhl.1	-	3		c.631G>A								Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit20-11-30-F.																		CTTAAAAGCTCCCTGGAATGT	0.428000													4	18					0	0	0.000602214	0	0
OR8K5	219453	broad.mit.edu	37	11	55927529	55927529	+	Nonsense_Mutation	SNP	G	A	A	rs147577134		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:55927529G>A	uc010rja.1	-	1	265	c.265C>T	c.(265-267)CGA>TGA	p.R89*		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATAGTATTTCGATCCACAACA	0.393000													16	68					0	0	0.000422831	0	0
OSBP	5007	broad.mit.edu	37	11	59368790	59368790	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:59368790C>T	uc001noc.1	-	5	1570	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	OSBP_uc009ymr.1_5'Flank	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	364					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTGATGATCTCAGGTGCATCA	0.398000													7	39					0	0	0.000442599	0	0
DDB1	1642	broad.mit.edu	37	11	61094298	61094298	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:61094298G>A	uc001nrc.3	-	5	843	c.617C>T	c.(616-618)CCT>CTT	p.P206L	DDB1_uc010rle.1_Intron|DDB1_uc010rlf.1_Missense_Mutation_p.P206L|DDB1_uc010rlg.1_RNA|DDB1_uc001nrd.2_Missense_Mutation_p.P206L|DDB1_uc009ynl.1_Missense_Mutation_p.P93L	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	206	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CTGTTTCCAAGGGCCCTTATT	0.517000								NER					22	167					0	0	0.000878237	0	0
SNX15	29907	broad.mit.edu	37	11	64802341	64802341	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:64802341C>T	uc001oci.3	+	7	932	c.279C>T	c.(277-279)ATC>ATT	p.I93I	SNX15_uc009ypy.2_Silent_p.I93I|SNX15_uc001ocj.2_Silent_p.I93I|SNX15_uc001ock.2_Silent_p.I93I	NM_013306	NP_037438	Q9NRS6	SNX15_HUMAN	sorting nexin 15 isoform A	93	PX.				cell communication|intracellular protein transport	cytoplasmic vesicle membrane|cytosol	phosphatidylinositol binding|protein transporter activity			ovary(1)	1						CCTCAGTGATCGAGGAGCGGC	0.617000													7	40					0	0	0.000673444	0	0
ASAM	79827	broad.mit.edu	37	11	122955359	122955359	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:122955359C>T	uc001pyt.2	-	3	608	c.249G>A	c.(247-249)GTG>GTA	p.V83V		NM_024769	NP_079045	Q9H6B4	CLMP_HUMAN	adipocyte-specific adhesion molecule precursor	83	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane|tight junction					0		Breast(109;0.0025)|Lung NSC(97;0.0179)|all_lung(97;0.0182)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.73e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0446)		AAGCAAAGGCCACTCGGCCCT	0.507000													9	52					0	0	0.000442599	0	0
OR8D1	283159	broad.mit.edu	37	11	124180450	124180450	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:124180450G>A	uc010sag.1	-	1	213	c.213C>T	c.(211-213)TTC>TTT	p.F71F		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AGGAATAGCAGAAATCGACGA	0.463000													11	37					0	0	6.40141e-05	0	0
OR8D2	283160	broad.mit.edu	37	11	124189545	124189545	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:124189545G>A	uc010sah.1	-	1	549	c.549C>T	c.(547-549)CCC>CCT	p.P183P		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		GAGTCAATAAGGGGAGAATAT	0.448000													5	57					0	0	0.000602214	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709668	128709668	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr11:128709668C>T	uc001qeo.1	-	2	579	c.528G>A	c.(526-528)GGG>GGA	p.G176G	KCNJ1_uc001qep.1_Silent_p.G157G|KCNJ1_uc001qeq.1_Silent_p.G157G|KCNJ1_uc001qer.1_Silent_p.G157G|KCNJ1_uc001qes.1_Silent_p.G157G	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	176	Helical; Name=M2; (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CTAAGATGGCCCCACACATGA	0.463000													7	71					0	0	0.000442599	0	0
STYK1	55359	broad.mit.edu	37	12	10774478	10774478	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr12:10774478G>A	uc001qys.2	-	10	1582	c.1061C>T	c.(1060-1062)ACC>ATC	p.T354I		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	354	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						CACTTACATGGTATGTGTGCA	0.468000										HNSCC(73;0.22)			16	81					0	0	0.00074312	0	0
H3F3C	440093	broad.mit.edu	37	12	31944912	31944912	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr12:31944912C>T	uc001rkr.2	-	1	264	c.189G>A	c.(187-189)CGG>CGA	p.R63R		NM_001013699	NP_001013721	Q6NXT2	H3C_HUMAN	histone H3-like	63					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGGGCAGCTTCCGGATGAGCA	0.617000										HNSCC(67;0.2)			5	34					0	0	3.59834e-05	0	0
STAT2	6773	broad.mit.edu	37	12	56740351	56740351	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr12:56740351G>C	uc001slc.2	-	21	1997	c.1919C>G	c.(1918-1920)CCG>CGG	p.P640R	STAT2_uc001slb.2_Missense_Mutation_p.P182R|STAT2_uc001sld.2_Missense_Mutation_p.P636R	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	640	SH2.				interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TTCAGTCAGCGGGAGTGACTG	0.547000													3	42					0	0	0.00024832	0	0
CDK4	1019	broad.mit.edu	37	12	58145436	58145436	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr12:58145436T>A	uc001spv.2	-	2	292	c.65A>T	c.(64-66)AAG>ATG	p.K22M	CDK4_uc010ssb.1_Translation_Start_Site|CDK4_uc001spw.2_RNA|uc010ssc.1_RNA	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	22	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			ATCACGGGCCTTGTACACTGT	0.557000			Mis			melanoma 			Hereditary_Melanoma				12	33					0	0	0.00010058	0	0
OASL	8638	broad.mit.edu	37	12	121471302	121471302	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr12:121471302G>A	uc001tzj.1	-	2	449	c.443C>T	c.(442-444)CCC>CTC	p.P148L	OASL_uc001tzk.1_Missense_Mutation_p.P148L	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	148					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GACCGTGATGGGCTCCGCAGT	0.632000													26	127					0	0	0.000147802	0	0
SACS	26278	broad.mit.edu	37	13	23911699	23911699	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr13:23911699G>A	uc001uon.2	-	10	6905	c.6316C>T	c.(6316-6318)CCT>TCT	p.P2106S	SACS_uc001uoo.2_Missense_Mutation_p.P1959S|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2106					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AAAACCAAAGGATGCCCCTCC	0.398000													5	27					0	0	0.000602214	0	0
MYH7	4625	broad.mit.edu	37	14	23886453	23886453	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:23886453G>A	uc001wjx.2	-	32	4534	c.4428C>T	c.(4426-4428)TCC>TCT	p.S1476S		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1476	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTGTGCTGAGGGAGCGAGCCT	0.577000													13	53					0	0	0.000308642	0	0
IPO4	79711	broad.mit.edu	37	14	24652822	24652823	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:24652822_24652823GG>AA	uc001wmv.1	-	20	2167_2168	c.2036_2037CC>TT	c.(2035-2037)GCC>GTT	p.A679V	IPO4_uc001wmt.1_Missense_Mutation_p.A157V|IPO4_uc001wmu.2_Missense_Mutation_p.A341V|IPO4_uc001wmx.1_Missense_Mutation_p.A543V|IPO4_uc001wmy.1_Missense_Mutation_p.A543V|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.A679V	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	679					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TCTCCCCCACGGCAGCACAGGT	0.574000													7	18					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	14	36840930	36840930	+	Silent	SNP	G	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:36840930G>T	uc001wtp.2	+	1	561	c.312G>T	c.(310-312)CTG>CTT	p.L104L		NM_199286	NP_954980			stella																		ACATGTTACTGGGCGGAGTTC	0.458000													5	44					0.000602214	0.00759687	0.000602214	1	0
ESR2	2100	broad.mit.edu	37	14	64749369	64749369	+	Missense_Mutation	SNP	G	A	A	rs141516067		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:64749369G>A	uc001xha.1	-	2	803	c.335C>T	c.(334-336)TCG>TTG	p.S112L	ESR2_uc001xgu.2_Missense_Mutation_p.S112L|ESR2_uc001xgv.2_Missense_Mutation_p.S112L|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Missense_Mutation_p.S112L|ESR2_uc001xgy.1_Missense_Mutation_p.S112L|ESR2_uc001xgz.1_Missense_Mutation_p.S112L|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Missense_Mutation_p.S112L	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	112	Modulating.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GTGTTCTAGCGATCTTGCTTC	0.448000													12	41					0	0	0.00010058	0	0
SLC10A1	6554	broad.mit.edu	37	14	70245170	70245170	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:70245170G>A	uc001xlr.2	-	4	957	c.823C>T	c.(823-825)CCA>TCA	p.P275S		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	275					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		ACTTCAGGTGGAAAGGCCACA	0.493000													15	59					0	0	0.000219431	0	0
FLRT2	23768	broad.mit.edu	37	14	86088234	86088234	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:86088234C>T	uc001xvr.2	+	2	1143	c.376C>T	c.(376-378)CGG>TGG	p.R126W	FLRT2_uc010atd.2_Missense_Mutation_p.R126W	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	126	LRR 3.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GACCATTTCACGGGCTGCTCT	0.517000													8	67					0	0	0.000442599	0	0
C14orf159	80017	broad.mit.edu	37	14	91642291	91642291	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:91642291C>T	uc001xzb.2	+	9	1374	c.606C>T	c.(604-606)ATC>ATT	p.I202I	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Silent_p.I207I|C14orf159_uc001xyx.2_Silent_p.I190I|C14orf159_uc001xyw.2_Silent_p.I207I|C14orf159_uc001xzc.2_Silent_p.I202I|C14orf159_uc001xza.2_Silent_p.I207I|C14orf159_uc001xyv.2_Silent_p.I207I|C14orf159_uc001xyz.2_Silent_p.I78I|C14orf159_uc001xze.2_Silent_p.I202I	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	202						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		TGTTGGGAATCAAAGAGCTTT	0.488000													11	66					0	0	0.000219431	0	0
CLMN	79789	broad.mit.edu	37	14	95677043	95677043	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr14:95677043G>C	uc001yef.2	-	7	898	c.782C>G	c.(781-783)CCC>CGC	p.P261R		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	261	Actin-binding.|CH 2.					integral to membrane	actin binding				0				Epithelial(152;0.193)		CAGGAGCCTGGGGATGTGCAG	0.383000													3	75					0	0	0.000602214	0	0
ACTC1	70	broad.mit.edu	37	15	35085458	35085458	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:35085458C>T	uc001ziu.1	-	3	685	c.442G>A	c.(442-444)GGC>AGC	p.G148S	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	148					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GTGGTACGGCCAGAAGCATAC	0.522000													10	51					0	0	0.000673444	0	0
BAHD1	22893	broad.mit.edu	37	15	40758203	40758203	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:40758203C>T	uc001zlu.2	+	7	2288	c.2217C>T	c.(2215-2217)CCC>CCT	p.P739P	BAHD1_uc001zlt.2_Silent_p.P738P|BAHD1_uc010bbp.1_Silent_p.P735P|BAHD1_uc001zlv.2_Silent_p.P736P	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	739	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CACTGGTTCCCCCCTCTGCAG	0.597000													19	80					0	0	0.000295444	0	0
MGA	23269	broad.mit.edu	37	15	42057258	42057258	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:42057258C>A	uc010ucy.1	+	23	8100	c.7919C>A	c.(7918-7920)CCA>CAA	p.P2640Q	MGA_uc010ucz.1_Missense_Mutation_p.P2431Q	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	2601						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GTGGCTCTACCAGGTATGTTG	0.443000													9	160					0.000274275	0.00348249	0.000274275	1	0
RFX7	64864	broad.mit.edu	37	15	56386014	56386014	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:56386014G>A	uc010bfn.2	-	9	3912	c.3912C>T	c.(3910-3912)TCC>TCT	p.S1304S	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Silent_p.S1118S	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	1207					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						CAGAAGTGCTGGAATCGATCA	0.418000													18	57					0	0	0.00074312	0	0
CGNL1	84952	broad.mit.edu	37	15	57745952	57745952	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:57745952A>G	uc002aeg.2	+	7	2202	c.2126A>G	c.(2125-2127)GAA>GGA	p.E709G	CGNL1_uc010bfw.2_Missense_Mutation_p.E709G	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	709	Potential.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		CAGCTCTCAGAAATGCACGAT	0.552000													8	42					0	0	6.40141e-05	0	0
GCNT3	9245	broad.mit.edu	37	15	59911588	59911588	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:59911588G>A	uc002age.2	+	3	1600	c.1151G>A	c.(1150-1152)GGA>GAA	p.G384E	GCNT3_uc002agd.2_Missense_Mutation_p.G384E	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	384	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						CCCTGCTCTGGAATCCACCAG	0.507000													23	111					0	0	0.000295444	0	0
C15orf60	283677	broad.mit.edu	37	15	73843312	73843312	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:73843312G>A	uc002avq.2	+	4	395	c.367G>A	c.(367-369)GGA>AGA	p.G123R	C15orf60_uc010bjb.2_Missense_Mutation_p.G95R	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	123										pancreas(1)	1						ACAGTTCAGTGGAGAGTCAAA	0.468000													5	73					0	0	8.12818e-05	0	0
ACSBG1	23205	broad.mit.edu	37	15	78466040	78466040	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:78466040C>T	uc002bdh.2	-	13	2040	c.1984G>A	c.(1984-1986)GAA>AAA	p.E662K	ACSBG1_uc010umw.1_Missense_Mutation_p.E658K|ACSBG1_uc010umx.1_Missense_Mutation_p.E420K	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	662					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						ATCCCCTCTTCGATGGCCTGG	0.582000													9	36					0	0	0.000274275	0	0
ANPEP	290	broad.mit.edu	37	15	90349755	90349755	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:90349755C>T	uc002bop.3	-	2	352	c.60G>A	c.(58-60)GTG>GTA	p.V20V		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	20	Helical; Signal-anchor for type II membrane protein; (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	ACACGGCTGCCACGCCCAGGA	0.632000													6	39					0	0	3.59834e-05	0	0
SV2B	9899	broad.mit.edu	37	15	91795180	91795180	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr15:91795180G>C	uc002bqv.2	+	2	974	c.583G>C	c.(583-585)GTG>CTG	p.V195L	SV2B_uc002bqt.2_Missense_Mutation_p.V195L|SV2B_uc010uqv.1_Missense_Mutation_p.V44L|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	195	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTCTTCCTTCGTGCAGGGATA	0.587000													31	232					0	0	0.000953801	0	0
PKD1	5310	broad.mit.edu	37	16	2159259	2159259	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:2159259G>A	uc002cos.1	-	15	6118	c.5909C>T	c.(5908-5910)GCC>GTC	p.A1970V	PKD1_uc002cot.1_Missense_Mutation_p.A1970V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1970	Extracellular (Potential).|PKD 15.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCACTCACGGCCTCCAGCAC	0.697000													6	32					0	0	3.59834e-05	0	0
ACSM2B	348158	broad.mit.edu	37	16	20559719	20559719	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:20559719G>A	uc002dhj.3	-	8	1181	c.971C>T	c.(970-972)TCC>TTC	p.S324F	ACSM2B_uc002dhk.3_Missense_Mutation_p.S324F|ACSM2B_uc010bwf.1_Missense_Mutation_p.S324F	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	324					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CCATCACCTGGAAAGATCCTG	0.498000													14	45					0	0	0.000566183	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24942154	24942154	+	Silent	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:24942154C>G	uc002dnb.2	-	19	2559	c.2466G>C	c.(2464-2466)GGG>GGC	p.G822G	ARHGAP17_uc002dmx.2_Silent_p.G84G|ARHGAP17_uc002dmw.2_Silent_p.G84G|ARHGAP17_uc002dmy.2_Silent_p.G267G|ARHGAP17_uc002dmz.2_Silent_p.G346G|ARHGAP17_uc002dna.2_Silent_p.G549G|ARHGAP17_uc002dnc.2_Silent_p.G744G|ARHGAP17_uc010vcf.1_Silent_p.G565G|ARHGAP17_uc002dne.1_Silent_p.G84G	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	822					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		GGCTGCTGTCCCCAGCTGAGT	0.557000													4	185					0	0	0.00024832	0	0
MT4	84560	broad.mit.edu	37	16	56602771	56602771	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:56602771C>T	uc002eje.1	+	3	196	c.116C>T	c.(115-117)CCC>CTC	p.P39L		NM_032935	NP_116324	P47944	MT4_HUMAN	metallothionein 4	39						cytoplasm	copper ion binding|zinc ion binding			ovary(1)	1						CCCTGCTGCCCCCCGGGCTGT	0.607000													12	109					0	0	0.000219431	0	0
SLC12A3	6559	broad.mit.edu	37	16	56899360	56899360	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:56899360C>T	uc010ccm.2	+	1	242	c.213C>T	c.(211-213)GCC>GCT	p.A71A	SLC12A3_uc002ekd.3_Silent_p.A71A|SLC12A3_uc010ccn.2_Silent_p.A71A	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	71	Cytoplasmic (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	AGCACTATGCCAACAGCACCC	0.572000													10	83					0	0	0.000442599	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67320969	67320969	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr16:67320969C>T	uc002eso.3	+	17	5527	c.2992C>T	c.(2992-2994)CGC>TGC	p.R998C	PLEKHG4_uc002esp.3_Missense_Mutation_p.R805C|PLEKHG4_uc002esq.3_Missense_Mutation_p.R998C|PLEKHG4_uc010cef.2_Missense_Mutation_p.R998C|PLEKHG4_uc002ess.3_Missense_Mutation_p.R998C|PLEKHG4_uc010ceg.2_Missense_Mutation_p.R917C	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	998	PH.			R -> G (in Ref. 3; AAH54486).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CTGGTTCCGCCGCCGCAAGGC	0.627000													6	24					0	0	3.59834e-05	0	0
TP53	7157	broad.mit.edu	37	17	7579312	7579312	+	Silent	SNP	C	T	T	rs55863639		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:7579312C>T	uc002gim.2	-	4	569	c.375G>A	c.(373-375)ACG>ACA	p.T125T	TP53_uc002gig.1_Silent_p.T125T|TP53_uc002gih.2_Silent_p.T125T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Silent_p.T125T|TP53_uc010cni.1_Silent_p.T125T|TP53_uc002gij.2_Silent_p.T125T|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Silent_p.T86T|TP53_uc010cnk.1_Silent_p.T140T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	125	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		T -> A (in a sporadic cancer; somatic mutation).|T -> M (in sporadic cancers; somatic mutation).|T -> R (in sporadic cancers; somatic mutation).|T -> P (in a sporadic cancer; somatic mutation).|T -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.T125T(15)|p.0?(7)|p.T125M(7)|p.T125K(3)|p.T125R(3)|p.?(2)|p.V73fs*9(1)|p.T125P(1)|p.G105_T125del21(1)|p.Y126fs*11(1)|p.T125fs*45(1)|p.T125fs*24(1)|p.T125A(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAACTGACCGTGCAAGTCA	0.537000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	63					0	0	0.00074312	0	0
CHD3	1107	broad.mit.edu	37	17	7811803	7811803	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:7811803T>G	uc002gje.2	+	35	5386	c.5236T>G	c.(5236-5238)TAT>GAT	p.Y1746D	CHD3_uc002gjd.2_Missense_Mutation_p.Y1805D|CHD3_uc002gjf.2_Missense_Mutation_p.Y1712D|CHD3_uc002gjh.2_Missense_Mutation_p.Y323D|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1746	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				AAGACATGACTATTGGCTTCT	0.458000													7	27					0	0	0.000157383	0	0
CCDC42	146849	broad.mit.edu	37	17	8638800	8638800	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:8638800C>T	uc002gln.2	-	5	849	c.622G>A	c.(622-624)GAG>AAG	p.E208K	CCDC42_uc002glo.2_Intron	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	208	Potential.			Missing (in Ref. 2; AAH29224).						ovary(1)	1						TCCTTTTCCTCCATGTAGCGC	0.572000													7	34					0	0	0.000157383	0	0
CCDC144A	9720	broad.mit.edu	37	17	16635973	16635973	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:16635973A>G	uc002gqk.1	+	11	2487	c.2411A>G	c.(2410-2412)AAT>AGT	p.N804S	CCDC144A_uc002gql.1_Missense_Mutation_p.N274S|LOC162632_uc010cpj.1_RNA	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	804	Potential.										0						AAGAAAATGAATTCTGAGGTA	0.313000													9	16					0	0	0.000274275	0	0
CASC3	22794	broad.mit.edu	37	17	38318286	38318286	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:38318286G>A	uc010cwt.1	+	5	783	c.488G>A	c.(487-489)GGT>GAT	p.G163D	CASC3_uc010cws.1_Missense_Mutation_p.G163D|CASC3_uc002hue.2_Missense_Mutation_p.G163D	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	163	Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles.|Sufficient to form the EJC.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						AACAAAGTGGGTAAAAAGGGC	0.463000													10	31					0	0	0.000442599	0	0
KRT34	3885	broad.mit.edu	37	17	39535984	39535984	+	Splice_Site	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:39535984C>T	uc002hwm.2	-	4	727	c.715_splice	c.e4-1	p.E239_splice		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34						epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				TGTTAACCTCCTGTTGGAGAA	0.532000													6	20					0	0	0.000157383	0	0
MPP3	4356	broad.mit.edu	37	17	41891690	41891690	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:41891690C>T	uc002iei.3	-	15	1215	c.1049G>A	c.(1048-1050)AGA>AAA	p.R350K	MPP3_uc002ieh.2_Missense_Mutation_p.R375K|MPP3_uc002iej.2_RNA	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	350					signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GCCACCCAGTCTCTCCCTACA	0.617000													12	54					0	0	0.000151284	0	0
GJC1	10052	broad.mit.edu	37	17	42882796	42882796	+	Silent	SNP	C	T	T	rs45478503	byFrequency	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:42882796C>T	uc002ihj.2	-	2	901	c.390G>A	c.(388-390)ACG>ACA	p.T130T	GJC1_uc002ihk.2_Silent_p.T130T|GJC1_uc002ihl.2_Silent_p.T130T|GJC1_uc010czx.2_Silent_p.T130T|GJC1_uc010czy.1_5'Flank	NM_005497	NP_005488	P36383	CXG1_HUMAN	connexin 45	130	Cytoplasmic (Potential).				cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane					0		Prostate(33;0.0959)				TGTCCTCCTCCGTTTCTTCCA	0.483000													19	73					0	0	0.000175454	0	0
ACSF2	80221	broad.mit.edu	37	17	48549854	48549854	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:48549854C>T	uc002iqu.2	+	12	1493	c.1389C>T	c.(1387-1389)ATC>ATT	p.I463I	ACSF2_uc010wml.1_Silent_p.I420I|ACSF2_uc010wmm.1_Silent_p.I488I|ACSF2_uc010wmn.1_Silent_p.I450I|ACSF2_uc010wmo.1_Silent_p.I303I|ACSF2_uc010dbt.1_Intron	NM_025149	NP_079425	Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2 precursor	463					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AGCTGTGCATCCGAGGGTACT	0.602000													11	21					0	0	6.40141e-05	0	0
STXBP4	252983	broad.mit.edu	37	17	53155458	53155458	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:53155458A>G	uc002iuf.1	+	14	1415	c.1208A>G	c.(1207-1209)AAA>AGA	p.K403R	STXBP4_uc010dcd.1_Missense_Mutation_p.K381R	NM_178509	NP_848604	Q6ZWJ1	STXB4_HUMAN	syntaxin binding protein 4	403	Potential.					cytoplasm	calcium ion binding			ovary(1)	1						CAGGATTTAAAAAAGAGAATC	0.353000													17	47					0	0	0.00074312	0	0
OR4D1	26689	broad.mit.edu	37	17	56233041	56233041	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:56233041A>C	uc010wno.1	+	1	527	c.527A>C	c.(526-528)AAC>ACC	p.N176T	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	176	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCCTAGATAACTTCTACTGT	0.532000													14	48					0	0	0.000422831	0	0
MGAT5B	146664	broad.mit.edu	37	17	74868989	74868989	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr17:74868989G>A	uc002jtg.3	+	2	439	c.125G>A	c.(124-126)GGA>GAA	p.G42E	MGAT5B_uc002jth.2_Missense_Mutation_p.G42E|MGAT5B_uc002jti.2_Missense_Mutation_p.G53E			Q3V5L5	MGT5B_HUMAN	Homo sapiens GnT-IX mRNA for N-Acetylglucosaminyltransferase IX, complete cds.	42	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						ACGTCTCTGGGAGGCCAGTTC	0.622000													10	51					0	0	6.40141e-05	0	0
ZNF521	25925	broad.mit.edu	37	18	22805795	22805795	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr18:22805795C>A	uc002kvk.2	-	4	2334	c.2087G>T	c.(2086-2088)TGT>TTT	p.C696F	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.C696F|ZNF521_uc002kvl.2_Missense_Mutation_p.C476F	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	696	C2H2-type 16.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ACAACTCTCACAGATGTAATA	0.448000			T	PAX5	ALL								20	72					1.87028e-06	2.40606e-05	0.000229342	1	0
SHC2	25759	broad.mit.edu	37	19	425215	425215	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:425215G>A	uc002loq.3	-	10	1191	c.1191C>T	c.(1189-1191)GGC>GGT	p.G397G	SHC2_uc002lop.3_Silent_p.G138G	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	397	CH1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCACGTAGCCGTCCCCCG	0.716000													11	22					0	0	0.000673444	0	0
MED16	10025	broad.mit.edu	37	19	873506	873506	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:873506C>T	uc002lqd.1	-	11	1999	c.1848G>A	c.(1846-1848)CAG>CAA	p.Q616Q	MED16_uc010drw.1_Silent_p.Q441Q|MED16_uc002lqe.2_Silent_p.Q605Q|MED16_uc002lqf.2_Silent_p.Q605Q|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Silent_p.Q536Q|MED16_uc010xfx.1_Silent_p.Q461Q|MED16_uc010xfy.1_Silent_p.Q193Q	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	616					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTGCAAGAGCTGCTGCAGCG	0.612000													6	45					0	0	3.59834e-05	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841819	8841819	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:8841819G>A	uc010xkg.1	+	1	429	c.429G>A	c.(427-429)CTG>CTA	p.L143L		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						TATGTCTGCTGATGATGGGCT	0.547000													7	51					0	0	0.000157383	0	0
MUC16	94025	broad.mit.edu	37	19	9085769	9085769	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:9085769G>A	uc002mkp.2	-	1	6250	c.6046C>T	c.(6046-6048)CAT>TAT	p.H2016Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2016	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAATTCTCATGGGTAGGGGAA	0.463000													8	64					0	0	0.000274275	0	0
ZNF266	10781	broad.mit.edu	37	19	9524605	9524605	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:9524605G>A	uc002mll.2	-	4	1262	c.996C>T	c.(994-996)TCC>TCT	p.S332S	ZNF266_uc002mlm.2_Silent_p.S332S|ZNF266_uc002mln.2_Silent_p.S332S|ZNF266_uc002mlo.2_Silent_p.S332S|ZNF266_uc010dwp.2_Silent_p.S332S|ZNF266_uc010dwq.2_Silent_p.S332S	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	332	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AATTTCTAAAGGATTTTCCAC	0.383000													15	63					0	0	0.000422831	0	0
COL5A3	50509	broad.mit.edu	37	19	10097052	10097052	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:10097052C>T	uc002mmq.1	-	30	2377	c.2291G>A	c.(2290-2292)GGG>GAG	p.G764E		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	764	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCCCTTCGGCCCCTCAGGACC	0.607000													4	14					0	0	0.00024832	0	0
CDC37	11140	broad.mit.edu	37	19	10506832	10506832	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:10506832C>T	uc002mof.1	-	2	266	c.150G>A	c.(148-150)CTG>CTA	p.L50L	CDC37_uc002moe.1_5'Flank|CDC37_uc010dxf.1_5'UTR|CDC37_uc002mog.1_Silent_p.L50L|CDC37_uc002moh.2_Silent_p.L50L	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	50					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AGCCCCTGTCCAGTTCCTCCT	0.662000													10	55					0	0	6.40141e-05	0	0
OR10H2	26538	broad.mit.edu	37	19	15839540	15839540	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:15839540C>T	uc002nbm.2	+	1	707	c.687C>T	c.(685-687)ATC>ATT	p.I229I		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TCTTGAAGATCCCTTCTGCTG	0.537000													16	53					0	0	0.000422831	0	0
ZNF506	440515	broad.mit.edu	37	19	19906068	19906068	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:19906068A>G	uc010eci.2	-	4	776	c.628T>C	c.(628-630)TAT>CAT	p.Y210H	ZNF506_uc002nog.2_Intron|ZNF506_uc002noh.3_Missense_Mutation_p.Y178H	NM_001099269	NP_001092739	Q5JVG8	ZN506_HUMAN	zinc finger protein 506 isoform 1	210	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding				0						GACTGCTTATAGGCTTTACCA	0.373000													11	22					0	0	6.40141e-05	0	0
LOC100101266	100101266	broad.mit.edu	37	19	24345488	24345488	+	RNA	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:24345488C>T	uc010edb.1	-	1		c.762G>A				NR_003603				Homo sapiens hepatitis A virus cellular receptor 1 pseudogene (LOC100101266), non-coding RNA.												0						ATTCCAAAGGCCATCTGAAGA	0.453000													28	184					0	0	0.000878237	0	0
CYP2A7	1549	broad.mit.edu	37	19	41387548	41387548	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:41387548C>T	uc002opm.2	-	2	831	c.289G>A	c.(289-291)GAG>AAG	p.E97K	CYP2A7_uc002opo.2_Missense_Mutation_p.E97K|CYP2A7_uc002opn.2_Intron	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	97						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CCGCTGAACTCCTCAGCCTGG	0.642000													5	51					0	0	0.000442599	0	0
ZNF225	7768	broad.mit.edu	37	19	44635207	44635207	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:44635207C>T	uc002oyj.1	+	5	683	c.440C>T	c.(439-441)CCT>CTT	p.P147L	ZNF225_uc010eje.1_Missense_Mutation_p.P64L|ZNF225_uc010ejf.1_Missense_Mutation_p.P147L	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	147				RQKP -> KTET (in Ref. 1; AAF04107).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGACAGAAACCTTCTGAGGGT	0.413000													19	142					0	0	0.00074312	0	0
RELB	5971	broad.mit.edu	37	19	45540674	45540674	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:45540674C>T	uc002paj.1	+	13	1492	c.1366C>T	c.(1366-1368)CCG>TCG	p.P456S	SFRS16_uc002pak.2_5'Flank|SFRS16_uc002pal.2_5'Flank|SFRS16_uc010xxh.1_5'Flank|SFRS16_uc002pam.2_5'Flank|SFRS16_uc002pan.1_5'Flank	NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	456						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CCCGTTCCTCCCGCCGTCAGC	0.592000													27	182					0	0	0.000184323	0	0
IGFL2	147920	broad.mit.edu	37	19	46663934	46663934	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:46663934A>G	uc010xxv.1	+	3	173	c.137A>G	c.(136-138)AAC>AGC	p.N46S	IGFL2_uc002peb.2_Missense_Mutation_p.N57S	NM_001135113	NP_001128585	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2 isoform b	46						extracellular region	protein binding				0		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		AAGATCTACAACCCCTTGGAG	0.592000													18	164					0	0	0.000958276	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021673	51021673	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:51021673G>A	uc002pss.2	-	3	1434	c.1297C>T	c.(1297-1299)CAG>TAG	p.Q433*		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	433	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CACGTGTACTGGCCCGTGTCC	0.577000													7	57					0	0	0.000442599	0	0
CD33	945	broad.mit.edu	37	19	51729088	51729088	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:51729088C>T	uc002pwa.2	+	3	488	c.448C>T	c.(448-450)CCT>TCT	p.P150S	CD33_uc010eos.1_Missense_Mutation_p.P150S|CD33_uc010eot.1_Missense_Mutation_p.P23S|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	150	Extracellular (Potential).|Ig-like C2-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AATCCTCATCCCTGGCACTCT	0.577000													7	69					0	0	0.000157383	0	0
LIM2	3982	broad.mit.edu	37	19	51883823	51883823	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:51883823C>T	uc002pwm.2	-	4	440	c.396G>A	c.(394-396)GGG>GGA	p.G132G	LIM2_uc002pwl.2_Silent_p.G174G	NM_001161748	NP_001155220	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa isoform	132	Extracellular (Potential).				cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens				0		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		AGCGCCAGTCCCCAAAGCGGC	0.537000													16	76					0	0	0.000132079	0	0
ZNF578	147660	broad.mit.edu	37	19	53015138	53015138	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:53015138C>T	uc002pzp.3	+	6	1748	c.1504C>T	c.(1504-1506)CGT>TGT	p.R502C		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	277	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TCCATGCCATCGTAGACTTCA	0.403000													6	49					0	0	3.59834e-05	0	0
NLRP12	91662	broad.mit.edu	37	19	54304614	54304614	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:54304614C>T	uc002qch.3	-	7	2843	c.2623G>A	c.(2623-2625)GAG>AAG	p.E875K	NLRP12_uc010eqw.2_Missense_Mutation_p.E158K|NLRP12_uc002qci.3_Missense_Mutation_p.E875K|NLRP12_uc002qcj.3_Missense_Mutation_p.E876K|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	875	LRR 2.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GAGGCCAGCTCGTCACAGGCA	0.517000													7	42					0	0	8.12818e-05	0	0
PTPRH	5794	broad.mit.edu	37	19	55718140	55718140	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:55718140C>T	uc002qjq.2	-	3	342	c.269G>A	c.(268-270)GGA>GAA	p.G90E	PTPRH_uc010esv.2_Missense_Mutation_p.G90E|PTPRH_uc002qjs.2_Missense_Mutation_p.G97E	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	90	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGACCCGGGTCCAAGGCCATC	0.542000													9	56					0	0	0.000274275	0	0
ZNF582	147948	broad.mit.edu	37	19	56896026	56896026	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:56896026G>A	uc002qmz.1	-	5	919	c.760C>T	c.(760-762)CCG>TCG	p.P254S	ZNF582_uc002qmy.2_Missense_Mutation_p.P285S	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		CATTCATACGGTTTCTCACCA	0.398000													6	36					0	0	3.59834e-05	0	0
ZNF211	10520	broad.mit.edu	37	19	58152517	58152517	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr19:58152517C>T	uc002qpq.2	+	3	843	c.663C>T	c.(661-663)GCC>GCT	p.A221A	ZNF211_uc010yhb.1_Silent_p.A225A|ZNF211_uc002qpp.2_Silent_p.A234A|ZNF211_uc002qpr.2_Silent_p.A285A|ZNF211_uc002qps.2_Silent_p.A286A|ZNF211_uc002qpt.2_Silent_p.A233A|ZNF211_uc010yhc.1_Silent_p.A233A|ZNF211_uc010yhd.1_Silent_p.A160A|ZNF211_uc010yhe.1_Silent_p.A212A	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	221						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGCGGTGGCCTTTTACAGTG	0.468000													5	61					0	0	0.000602214	0	0
RPS7	6201	broad.mit.edu	37	2	3627805	3627805	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:3627805A>G	uc002qxw.2	+	6	568	c.462A>G	c.(460-462)ATA>ATG	p.I154M	RPS7_uc002qxy.2_RNA	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	154					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		GCCGGCTCATAAAGGTTCATT	0.468000													10	58					0	0	0.000673444	0	0
APOB	338	broad.mit.edu	37	2	21231507	21231507	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:21231507G>A	uc002red.2	-	26	8361	c.8233C>T	c.(8233-8235)CAC>TAC	p.H2745Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2745					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTGAGATGTGGGGAAGCTGG	0.393000													75	420					0	0	0.000781405	0	0
TCF23	150921	broad.mit.edu	37	2	27373024	27373024	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:27373024C>G	uc010ylg.1	+	2	256	c.256C>G	c.(256-258)CGG>GGG	p.R86G		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	86	Basic motif (By similarity).				cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCGCGGGAGCGGAGCCGGGT	0.657000													3	42					0	0	6.4e-05	0	0
CAD	790	broad.mit.edu	37	2	27456998	27456998	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:27456998C>T	uc002rji.2	+	22	3684	c.3522C>T	c.(3520-3522)ATC>ATT	p.I1174I	CAD_uc010eyw.2_Silent_p.I1111I	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1174	CPSase B.|ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CACAAGATATCACTGCCAAAA	0.557000													7	49					0	0	8.12818e-05	0	0
FOSL2	2355	broad.mit.edu	37	2	28631669	28631669	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:28631669G>A	uc002rma.2	+	3	1207	c.398G>A	c.(397-399)AGG>AAG	p.R133K	FOSL2_uc010ymi.1_Missense_Mutation_p.R94K	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	133	Basic motif.				cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CGGCGGGAGAGGAACAAGCTG	0.582000													4	21					0	0	3.59834e-05	0	0
LCLAT1	253558	broad.mit.edu	37	2	30748459	30748459	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:30748459G>T	uc002rnj.2	+	3	326	c.117G>T	c.(115-117)ATG>ATT	p.M39I	LCLAT1_uc010ymp.1_Intron|LCLAT1_uc002rnk.1_Missense_Mutation_p.M39I|LCLAT1_uc002rnl.2_Missense_Mutation_p.M1I|LCLAT1_uc010ymq.1_Missense_Mutation_p.M1I	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	39					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						TCAGAATCATGGTGTCATGGA	0.328000													8	93					5.18039e-06	6.64249e-05	0.000157383	1	0
THADA	63892	broad.mit.edu	37	2	43802077	43802078	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:43802077_43802078GG>TT	uc002rsw.3	-	11	1478_1479	c.1126_1127CC>AA	c.(1126-1128)CCG>AAG	p.P376K	THADA_uc002rsx.3_Missense_Mutation_p.P376K|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.P86K|THADA_uc002rta.2_Missense_Mutation_p.P86K|THADA_uc002rtb.1_Missense_Mutation_p.P376K|THADA_uc002rtc.3_Missense_Mutation_p.P376K|THADA_uc002rtd.2_Missense_Mutation_p.P376K	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	376							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CGTTAGGCTCGGGGAACTTGAT	0.426000													16	499					0	0	6.4e-05	0	0
APLF	200558	broad.mit.edu	37	2	68772353	68772353	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:68772353C>T	uc002sep.2	+	8	1368	c.1195C>T	c.(1195-1197)CCT>TCT	p.P399S	APLF_uc002seq.1_RNA|APLF_uc010fdf.2_Missense_Mutation_p.P375S|APLF_uc002ser.1_Missense_Mutation_p.P130S	NM_173545	NP_775816	Q8IW19	APLF_HUMAN	aprataxin and PNKP like factor	399					double-strand break repair|single strand break repair	cytosol|nucleus	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|metal ion binding|nucleotide binding|protein binding			ovary(2)	2						TTTTAGCCATCCTGGTGATAG	0.388000													13	54					0	0	0.000422831	0	0
ZNF638	27332	broad.mit.edu	37	2	71577070	71577070	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:71577070C>T	uc002shx.2	+	2	1305	c.986C>T	c.(985-987)CCT>CTT	p.P329L	ZNF638_uc010fec.2_Missense_Mutation_p.P435L|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.P329L|ZNF638_uc002shy.2_Missense_Mutation_p.P329L|ZNF638_uc002shz.2_Missense_Mutation_p.P329L|ZNF638_uc002sia.2_Missense_Mutation_p.P329L|ZNF638_uc002sib.1_Missense_Mutation_p.P329L	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	329					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TCTCTGATTCCTCCATCTATG	0.413000													17	147					0	0	0.000132079	0	0
TET3	200424	broad.mit.edu	37	2	74274273	74274273	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:74274273C>T	uc002skb.3	+	1	824	c.824C>T	c.(823-825)CCT>CTT	p.P275L	TET3_uc010fez.1_Missense_Mutation_p.P275L	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	275							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CCTGTGGTTCCTCCTGAAGAG	0.592000													10	52					0	0	0.00010058	0	0
VWA3B	200403	broad.mit.edu	37	2	98810890	98810890	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:98810890G>A	uc002syo.2	+	12	1936	c.1672G>A	c.(1672-1674)GAA>AAA	p.E558K	VWA3B_uc010yvh.1_Missense_Mutation_p.E408K|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Missense_Mutation_p.E77K|VWA3B_uc002sym.2_Missense_Mutation_p.E558K|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.E215K|VWA3B_uc002syp.1_5'UTR	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	558	VWFA.									ovary(3)|large_intestine(2)|skin(1)	6						TGCTTGGCGGGAACAACTTGC	0.383000													36	204					0	0	0.000191422	0	0
PSD4	23550	broad.mit.edu	37	2	113942615	113942615	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:113942615G>A	uc002tjc.2	+	3	1321	c.1138G>A	c.(1138-1140)GAT>AAT	p.D380N	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.D379N|PSD4_uc002tjf.2_5'UTR	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	380					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						tgtcggatctgatcttggccc	0.124000													18	96					0	0	0.000566183	0	0
LOC401010	401010	broad.mit.edu	37	2	132201832	132201832	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:132201832G>A	uc002tst.2	-	1	636	c.170C>T	c.(169-171)ACC>ATC	p.T57I		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						GATGCAGAAGGTGACCAGAGC	0.577000													5	28					0	0	8.12818e-05	0	0
YSK4	80122	broad.mit.edu	37	2	135744054	135744054	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:135744054C>T	uc002tue.1	-	7	2419	c.2388G>A	c.(2386-2388)ATG>ATA	p.M796I	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.M683I|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.M524I|YSK4_uc002tui.3_Missense_Mutation_p.M813I	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	796							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CATTCTGTTTCATGGACTGCT	0.393000													17	79					0	0	0.000566183	0	0
XIRP2	129446	broad.mit.edu	37	2	168105217	168105217	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:168105217G>A	uc002udx.2	+	8	7333	c.7315G>A	c.(7315-7317)GAT>AAT	p.D2439N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2264N|XIRP2_uc010fpq.2_Missense_Mutation_p.D2217N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2264					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAATAAGAACGATTTTTCCCC	0.408000													29	121					0	0	0.000814825	0	0
LRP2	4036	broad.mit.edu	37	2	170031841	170031841	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:170031841C>T	uc002ues.2	-	55	10843	c.10630G>A	c.(10630-10632)GAA>AAA	p.E3544K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3544	LDL-receptor class A 26.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGGCCAGTTCATCAGAGCCA	0.527000													13	46					0	0	0.000422831	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173898662	173898662	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:173898662G>A	uc002uhv.3	+	27	2857	c.2670G>A	c.(2668-2670)AAG>AAA	p.K890K	RAPGEF4_uc002uhw.3_Silent_p.K746K	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	890	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GCAAGTTCAAGAAGTTCTATG	0.358000													11	53					0	0	0.000673444	0	0
TTN	7273	broad.mit.edu	37	2	179427423	179427423	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:179427423G>A	uc010zfg.1	-	275	75956	c.75732C>T	c.(75730-75732)GCC>GCT	p.A25244A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A18939A|TTN_uc010zfi.1_Silent_p.A18872A|TTN_uc010zfj.1_Silent_p.A18747A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26171							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGTAGCATAGGCTTTTCTTG	0.373000													9	66					0	0	0.000673444	0	0
TTN	7273	broad.mit.edu	37	2	179450006	179450006	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:179450006G>A	uc010zfg.1	-	258	56985	c.56761C>T	c.(56761-56763)CAT>TAT	p.H18921Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.H12616Y|TTN_uc010zfi.1_Missense_Mutation_p.H12549Y|TTN_uc010zfj.1_Missense_Mutation_p.H12424Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19848							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCATACACATGGGCTTCAATT	0.413000													38	185					0	0	0.000814825	0	0
TTN	7273	broad.mit.edu	37	2	179470419	179470419	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:179470419C>T	uc010zfg.1	-	228	46123	c.45899G>A	c.(45898-45900)AGG>AAG	p.R15300K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R8995K|TTN_uc010zfi.1_Missense_Mutation_p.R8928K|TTN_uc010zfj.1_Missense_Mutation_p.R8803K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16227							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTATGTGAGCCTCTCTGGAGA	0.393000													6	38					0	0	8.12818e-05	0	0
TTN	7273	broad.mit.edu	37	2	179612027	179612027	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:179612027C>T	uc002unb.2	-	46	15324	c.15100G>A	c.(15100-15102)GAA>AAA	p.E5034K	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1138							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGCAACTTCCCCTAAAGGT	0.433000													11	35					0	0	0.000151284	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802785	185802785	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:185802785C>T	uc002uph.2	+	4	3256	c.2662C>T	c.(2662-2664)CCT>TCT	p.P888S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	888						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CAATCTCCTTCCTTCTGAAAC	0.393000													10	55					0	0	0.000442599	0	0
FAM124B	79843	broad.mit.edu	37	2	225266283	225266283	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:225266283G>A	uc002vnx.2	-	1	429	c.203C>T	c.(202-204)TCC>TTC	p.S68F	FAM124B_uc002vnw.2_Missense_Mutation_p.S68F	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	68							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		GAGCAACACGGACATCCCTGG	0.572000													8	30					0	0	0.000274275	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910836	230910836	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:230910836G>A	uc002vqd.1	-	4	1369	c.1006C>T	c.(1006-1008)CAC>TAC	p.H336Y	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.H336Y|SLC16A14_uc002vqf.2_Missense_Mutation_p.H336Y	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	336	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TCTGGGAGGTGAATGAAGGGG	0.403000													8	40					0	0	0.000274275	0	0
INPP5D	3635	broad.mit.edu	37	2	234072391	234072391	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:234072391C>T	uc010zmo.1	+	11	1432	c.1279C>T	c.(1279-1281)CTC>TTC	p.L427F	INPP5D_uc010zmp.1_Missense_Mutation_p.L426F	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	427					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GTCCTGGTTTCTCTCCAAGGG	0.547000													9	101					0	0	0.000442599	0	0
COL6A3	1293	broad.mit.edu	37	2	238285737	238285737	+	Silent	SNP	C	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr2:238285737C>A	uc002vwl.2	-	7	3033	c.2748G>T	c.(2746-2748)CTG>CTT	p.L916L	COL6A3_uc002vwo.2_Silent_p.L710L|COL6A3_uc010znj.1_Silent_p.L309L|COL6A3_uc002vwq.2_Silent_p.L710L|COL6A3_uc002vwr.2_Silent_p.L509L|COL6A3_uc010znk.1_Silent_p.L716L	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	916	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCGCGTAGCCCAGGTTGAGGG	0.527000													12	59					6.40141e-05	0.000818121	6.40141e-05	1	0
HCK	3055	broad.mit.edu	37	20	30667604	30667604	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr20:30667604G>A	uc002wxh.2	+	6	627	c.456G>A	c.(454-456)AAG>AAA	p.K152K	HCK_uc010gdy.2_Silent_p.K131K|HCK_uc002wxi.2_Silent_p.K130K	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	152	SH2.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCAGCCGGAAGGACGCAGAGC	0.587000													5	34					0	0	3.59834e-05	0	0
SUN5	140732	broad.mit.edu	37	20	31583483	31583484	+	Missense_Mutation	DNP	CG	AT	AT	rs144823079	byFrequency	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr20:31583483_31583484CG>AT	uc002wyi.2	-	8	568_569	c.475_476CG>AT	c.(475-477)CGA>ATA	p.R159I		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like	159	Potential.				spermatogenesis					skin(1)	1						CATGCTACCTCGGAGGTCCTGG	0.485000													7	246					0	0	6.4e-05	0	0
EPB41L1	2036	broad.mit.edu	37	20	34800280	34800280	+	Silent	SNP	C	T	T	rs138806418		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr20:34800280C>T	uc002xfb.2	+	16	2337	c.2166C>T	c.(2164-2166)TCC>TCT	p.S722S	EPB41L1_uc002xeu.2_Silent_p.S648S|EPB41L1_uc010zvo.1_Silent_p.S722S|EPB41L1_uc002xev.2_Silent_p.S722S|EPB41L1_uc002xew.2_Silent_p.S613S|EPB41L1_uc002xex.2_Silent_p.S542S|EPB41L1_uc002xey.2_Silent_p.S500S|EPB41L1_uc002xez.2_Silent_p.S648S|EPB41L1_uc010gfq.2_Silent_p.S821S	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	722					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CCAGAGTCTCCGCTATGGATA	0.522000													11	37					0	0	6.40141e-05	0	0
SEMG1	6406	broad.mit.edu	37	20	43836817	43836817	+	Silent	SNP	A	G	G	rs17850164		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr20:43836817A>G	uc002xni.2	+	2	936	c.879A>G	c.(877-879)ACA>ACG	p.T293T	SEMG1_uc002xnj.2_Intron|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Silent_p.T293T	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	293	58 AA repeat 1.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CTTCAAGTACAGAAGAAAGAC	0.383000													4	45					0	0	0.00024832	0	0
SYS1-DBNDD2	767557	broad.mit.edu	37	20	44037233	44037233	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr20:44037233C>T	uc002xnx.2	+	4	622	c.126C>T	c.(124-126)CTC>CTT	p.L42L	DBNDD2_uc002xnz.2_Silent_p.L42L|DBNDD2_uc002xoa.2_Silent_p.L42L|DBNDD2_uc002xob.2_Silent_p.L42L|DBNDD2_uc002xoc.2_Silent_p.L42L|DBNDD2_uc002xod.2_Silent_p.L42L|DBNDD2_uc002xoe.2_Silent_p.L42L|DBNDD2_uc002xof.2_Silent_p.L42L|DBNDD2_uc002xog.2_Silent_p.L42L	NM_001048225	NP_001041690			SCF apoptosis response protein 1 isoform a												0						ATCTGCATCTCGAGTCGCAGA	0.557000													16	49					0	0	0.000958276	0	0
TPTE	7179	broad.mit.edu	37	21	10906928	10906928	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr21:10906928C>T	uc002yip.1	-	24	2001	c.1633G>A	c.(1633-1635)GAT>AAT	p.D545N	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.D527N|TPTE_uc002yir.1_Missense_Mutation_p.D507N|TPTE_uc010gkv.1_Missense_Mutation_p.D407N	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	545					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.D527N(1)		ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTACAACATCACTGGAAGTC	0.383000													5	45					0	0	0.000602214	0	0
FAM3B	54097	broad.mit.edu	37	21	42720634	42720634	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr21:42720634G>A	uc002yzb.1	+	7	747	c.601G>A	c.(601-603)GAA>AAA	p.E201K	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Missense_Mutation_p.E153K|FAM3B_uc002yzd.1_Missense_Mutation_p.E224K	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	201					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				ACTCCCTTCCGAAATTCAGAG	0.413000													10	43					0	0	0.000442599	0	0
ITGB2	3689	broad.mit.edu	37	21	46310042	46310042	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr21:46310042G>A	uc002zgd.2	-	11	1552	c.1508C>T	c.(1507-1509)TCC>TTC	p.S503F	ITGB2_uc002zge.2_Missense_Mutation_p.S503F|ITGB2_uc002zgf.3_Missense_Mutation_p.S503F|ITGB2_uc011afl.1_Missense_Mutation_p.S425F|ITGB2_uc010gpw.2_Missense_Mutation_p.S446F|ITGB2_uc002zgg.2_Missense_Mutation_p.S503F	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	503	II.|Extracellular (Potential).|Cysteine-rich tandem repeats.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCAGATGATGGAGTTGTTGTC	0.607000													4	22					0	0	0.00024832	0	0
LOC96610	96610	broad.mit.edu	37	22	23241819	23241819	+	RNA	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr22:23241819C>T	uc011aim.1	+	366		c.15435C>T			uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						GCGGAGGGACCAAGCTGACCG	0.542000													4	35					0	0	3.59834e-05	0	0
MTMR3	8897	broad.mit.edu	37	22	30416562	30416562	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr22:30416562C>T	uc003agv.3	+	17	3242	c.2914C>T	c.(2914-2916)CGT>TGT	p.R972C	MTMR3_uc003agu.3_Missense_Mutation_p.R972C|MTMR3_uc003agw.3_Missense_Mutation_p.R972C	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	972					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			CTCACTGAGCCGTCAGCTGTC	0.582000													9	43					0	0	6.40141e-05	0	0
MFNG	4242	broad.mit.edu	37	22	37876777	37876777	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr22:37876777C>T	uc003ass.1	-	2	456	c.286G>A	c.(286-288)GGC>AGC	p.G96S	MFNG_uc011ani.1_Intron|MFNG_uc011anj.1_Intron|CARD10_uc003ast.1_RNA	NM_002405	NP_002396	O00587	MFNG_HUMAN	O-fucosylpeptide	96	Lumenal (Potential).				pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			lung(1)	1	Melanoma(58;0.0574)					TCCTGGAGGCCTTTGTCTGGG	0.617000													4	15					0	0	0.00024832	0	0
MOV10L1	54456	broad.mit.edu	37	22	50584155	50584155	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr22:50584155G>A	uc003bjj.2	+	19	2626	c.2543G>A	c.(2542-2544)GGA>GAA	p.G848E	MOV10L1_uc003bjk.3_Missense_Mutation_p.G848E|MOV10L1_uc011arp.1_Missense_Mutation_p.G828E|MOV10L1_uc003bjl.2_5'Flank	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	848					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGCAGAGACGGAGAAGACATC	0.498000													12	80					0	0	0.00010058	0	0
CNTN4	152330	broad.mit.edu	37	3	3081846	3081846	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:3081846G>A	uc003bpc.2	+	19	2510	c.2289G>A	c.(2287-2289)AGG>AGA	p.R763R	CNTN4_uc003bpb.1_Silent_p.R434R|CNTN4_uc003bpe.2_Silent_p.R435R|CNTN4_uc003bpf.2_Silent_p.R434R|CNTN4_uc003bpg.2_Silent_p.R19R	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	763	Fibronectin type-III 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACGTGTTCAGGAATGAGAGCG	0.522000													16	82					0	0	0.000566183	0	0
IQSEC1	9922	broad.mit.edu	37	3	12977268	12977268	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:12977268G>A	uc003bxt.2	-	3	1299	c.1290C>T	c.(1288-1290)CTC>CTT	p.L430L	IQSEC1_uc003bxu.3_Silent_p.L308L|IQSEC1_uc011auw.1_Silent_p.L416L	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	430					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						CCTCCCGGGGGAGGCTCTTGG	0.692000													6	22					0	0	3.59834e-05	0	0
FGD5	152273	broad.mit.edu	37	3	14862002	14862002	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:14862002G>A	uc003bzc.2	+	1	1534	c.1424G>A	c.(1423-1425)AGG>AAG	p.R475K	FGD5_uc011avk.1_Missense_Mutation_p.R475K	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	475					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CCCGCGGACAGGAAGAACACC	0.627000													11	52					0	0	0.000673444	0	0
THRB	7068	broad.mit.edu	37	3	24231676	24231676	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:24231676G>A	uc003ccx.3	-	5	521	c.172C>T	c.(172-174)CTC>TTC	p.L58F	THRB_uc010hfe.2_Missense_Mutation_p.L58F|THRB_uc003ccy.3_Missense_Mutation_p.L58F|THRB_uc003ccz.3_Missense_Mutation_p.L53F|THRB_uc003cdc.2_Missense_Mutation_p.L53F|THRB_uc003cdd.2_Missense_Mutation_p.L53F|THRB_uc003cde.1_Missense_Mutation_p.L53F	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	58	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	GTCTGGATGAGATGTGGCGAC	0.498000													6	71					0	0	0.000157383	0	0
CNOT10	25904	broad.mit.edu	37	3	32776307	32776307	+	Silent	SNP	G	A	A	rs147797250	by1000genomes	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:32776307G>A	uc003cfc.1	+	12	1608	c.1353G>A	c.(1351-1353)TCG>TCA	p.S451S	CNOT10_uc011axi.1_Silent_p.S223S|CNOT10_uc003cfd.1_Silent_p.S450S|CNOT10_uc003cfe.1_Silent_p.S451S|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Silent_p.S511S|CNOT10_uc010hfw.1_Silent_p.S146S	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	451					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						GGCAGTCTTCGGCCATTCCTG	0.383000													30	169					0	0	0.00058488	0	0
ITGA9	3680	broad.mit.edu	37	3	37785434	37785434	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:37785434C>T	uc003chd.2	+	22	2395	c.2342C>T	c.(2341-2343)TCC>TTC	p.S781F		NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	781	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		TCTCCAACCTCCTTTGTATAT	0.488000													7	72					0	0	0.000274275	0	0
CCR3	1232	broad.mit.edu	37	3	46307036	46307036	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:46307036C>T	uc003cpg.1	+	4	930	c.387C>T	c.(385-387)ATC>ATT	p.I129I	CCR3_uc003cpi.1_Silent_p.I129I|CCR3_uc003cpj.1_Silent_p.I129I|CCR3_uc003cpk.1_Silent_p.I150I|CCR3_uc010hjb.1_Silent_p.I147I|CCR3_uc003cpl.1_Silent_p.I162I	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	129	Helical; Name=3; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		TGCTGACAATCGACAGGTACC	0.522000													19	55					0	0	0.000958276	0	0
GLYCTK	132158	broad.mit.edu	37	3	52326291	52326291	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:52326291C>T	uc003ddo.2	+	5	817	c.721C>T	c.(721-723)CTG>TTG	p.L241L	GLYCTK_uc003ddq.2_Missense_Mutation_p.P182L|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Silent_p.L241L|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	241					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		GAGCCTCATCCTGTCAGATGT	0.592000													6	41					0	0	8.12818e-05	0	0
ITIH1	3697	broad.mit.edu	37	3	52823754	52823754	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:52823754C>T	uc003dfs.2	+	19	2229	c.2205C>T	c.(2203-2205)ATC>ATT	p.I735I	ITIH1_uc010hmn.1_RNA|ITIH1_uc003dft.2_Silent_p.I336I|ITIH1_uc010hmo.1_Silent_p.I289I|ITIH1_uc003dfu.2_Silent_p.I101I	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	735	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		GGCTGGGAATCGCAAACCCTG	0.577000													12	73					0	0	6.40141e-05	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55107818	55107818	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:55107818A>C	uc003dhf.2	+	37	3163	c.3115A>C	c.(3115-3117)AAG>CAG	p.K1039Q		NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	1039	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGAATCCCTTAAGTGTGAACG	0.423000													8	25					0	0	0.000442599	0	0
FLNB	2317	broad.mit.edu	37	3	58084611	58084611	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:58084611C>T	uc003djj.2	+	8	1486	c.1321C>T	c.(1321-1323)CCC>TCC	p.P441S	FLNB_uc010hne.2_Missense_Mutation_p.P441S|FLNB_uc003djk.2_Missense_Mutation_p.P441S|FLNB_uc010hnf.2_Missense_Mutation_p.P441S|FLNB_uc003djl.2_Missense_Mutation_p.P272S|FLNB_uc003djm.2_Missense_Mutation_p.P272S	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	441	Filamin 2.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCCTAAGAGTCCCTTCGTTGT	0.547000													11	44					0	0	6.40141e-05	0	0
KBTBD8	84541	broad.mit.edu	37	3	67058562	67058562	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:67058562C>T	uc003dmy.2	+	4	1612	c.1559C>T	c.(1558-1560)TCC>TTC	p.S520F	KBTBD8_uc011bfv.1_Missense_Mutation_p.S78F	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	520	Kelch 4.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TGTGATCAGTCCATAAATCCA	0.388000													15	79					0	0	0.000219431	0	0
FAM19A1	407738	broad.mit.edu	37	3	68587978	68587978	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:68587978C>T	uc003dnd.2	+	4	547	c.331C>T	c.(331-333)CCT>TCT	p.P111S	FAM19A1_uc003dne.2_Missense_Mutation_p.P111S|FAM19A1_uc003dng.2_Missense_Mutation_p.P111S	NM_213609	NP_998774	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine	111						endoplasmic reticulum|extracellular region				ovary(1)	1		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		TAAGACACTCCCTGACAATTC	0.428000													9	63					0	0	0.000673444	0	0
CADM2	253559	broad.mit.edu	37	3	85984998	85984998	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:85984998G>A	uc003dqj.2	+	6	1381	c.755G>A	c.(754-756)GGA>GAA	p.G252E	CADM2_uc003dqk.2_Missense_Mutation_p.G261E|CADM2_uc003dql.2_Missense_Mutation_p.G254E	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	252	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GAATCCAAAGGAAAACCACTG	0.318000													19	125					0	0	0.000375601	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111768813	111768813	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:111768813C>T	uc010hqb.2	+	6	874	c.704C>T	c.(703-705)CCA>CTA	p.P235L	TMPRSS7_uc011bhr.1_Missense_Mutation_p.P90L	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	361	Extracellular (Potential).				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						GAGGTCATTCCAGAACAAAGT	0.353000													7	62					0	0	0.000274275	0	0
ADPRH	141	broad.mit.edu	37	3	119301094	119301094	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:119301094C>T	uc003ecs.2	+	3	376	c.78C>T	c.(76-78)TTC>TTT	p.F26F	ADPRH_uc010hqv.2_Silent_p.F26F|ADPRH_uc011bjb.1_Intron|ADPRH_uc003ect.2_Silent_p.F26F	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	26					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AGTGGGAGTTCCTCCAGGATG	0.572000													10	41					0	0	0.000442599	0	0
IGSF10	285313	broad.mit.edu	37	3	151156350	151156350	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:151156350G>A	uc011bod.1	-	6	5999	c.5999C>T	c.(5998-6000)TCC>TTC	p.S2000F	IGSF10_uc011bob.1_Missense_Mutation_p.S27F|IGSF10_uc011boc.1_5'UTR	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2000	Ig-like C2-type 6.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AATAAACAGGGATCCATTAGG	0.433000													12	53					0	0	0.000308642	0	0
SI	6476	broad.mit.edu	37	3	164735612	164735612	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:164735612C>T	uc003fei.2	-	30	3632	c.3570G>A	c.(3568-3570)GGG>GGA	p.G1190G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1190	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AATCCAAGATCCCTCCAACTG	0.333000										HNSCC(35;0.089)			6	25					0	0	0.000157383	0	0
ZBBX	79740	broad.mit.edu	37	3	167000208	167000208	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:167000208G>A	uc003fep.2	-	19	2278	c.1955C>T	c.(1954-1956)TCA>TTA	p.S652L	ZBBX_uc011bpc.1_Missense_Mutation_p.S691L|ZBBX_uc003feq.2_Missense_Mutation_p.S623L	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	652	Ser-rich.					intracellular	zinc ion binding			ovary(2)	2						ATGAGAGGATGAAAGGCAACT	0.353000													31	181					0	0	0.000491102	0	0
ATP11B	23200	broad.mit.edu	37	3	182631767	182631767	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:182631767C>T	uc003flb.2	+	29	3694	c.3437C>T	c.(3436-3438)CCA>CTA	p.P1146L	ATP11B_uc003flc.2_Missense_Mutation_p.P730L|ATP11B_uc010hxg.2_RNA|ATP11B_uc010hxh.1_3'UTR	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	1146	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AGATGTAGTCCAACCCACATC	0.473000													22	103					0	0	0.000229342	0	0
ATP13A5	344905	broad.mit.edu	37	3	193039562	193039562	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:193039562G>A	uc011bsq.1	-	16	1823	c.1823C>T	c.(1822-1824)TCC>TTC	p.S608F		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	608					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		AGCGATCACGGACATCCTCTG	0.507000													9	49					0	0	0.000274275	0	0
SDHAP1	255812	broad.mit.edu	37	3	195692347	195692347	+	Missense_Mutation	SNP	G	A	A	rs62282794	by1000genomes	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr3:195692347G>A	uc003fvy.2	-	3	310	c.196C>T	c.(196-198)CAC>TAC	p.H66Y	SDHAP1_uc003fvx.3_RNA					Homo sapiens full length insert cDNA clone ZC24D06.												0						TTCCTCCAGTGCTCCTCAAAG	0.572000													5	25					0	0	3.59834e-05	0	0
ZNF721	170960	broad.mit.edu	37	4	436857	436857	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:436857G>A	uc003gag.2	-	3	2090	c.1399C>T	c.(1399-1401)CAT>TAT	p.H467Y	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.H499Y|ZNF721_uc010ibe.2_Missense_Mutation_p.H455Y	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	467						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TTTCCAGTATGAATTTTCTCA	0.358000													6	46					0	0	8.12818e-05	0	0
SLIT2	9353	broad.mit.edu	37	4	20598237	20598237	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:20598237C>T	uc003gpr.1	+	32	3724	c.3520C>T	c.(3520-3522)CCT>TCT	p.P1174S	SLIT2_uc003gps.1_Missense_Mutation_p.P1166S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1174	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TCTTCAGATTCCTTCAGCCAA	0.388000													5	42					0	0	3.59834e-05	0	0
TBC1D1	23216	broad.mit.edu	37	4	38091627	38091627	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:38091627C>G	uc003gtb.2	+	13	2468	c.2125C>G	c.(2125-2127)CCA>GCA	p.P709A	TBC1D1_uc011byd.1_Missense_Mutation_p.P803A|TBC1D1_uc010ifd.2_Missense_Mutation_p.P496A|TBC1D1_uc011byf.1_Missense_Mutation_p.P580A	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	709						nucleus	Rab GTPase activator activity			ovary(1)	1						CTTTGGCCCCCCACCAGAGGA	0.493000													3	91					0	0	6.4e-05	0	0
UBE2K	3093	broad.mit.edu	37	4	39757304	39757304	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:39757304C>T	uc003guu.3	+	4	528	c.244C>T	c.(244-246)CCT>TCT	p.P82S	UBE2K_uc003gus.3_Missense_Mutation_p.P82S|UBE2K_uc003gut.3_Missense_Mutation_p.P31S|UBE2K_uc010ifn.2_RNA|UBE2K_uc011byq.1_Intron|UBE2K_uc003guq.3_5'UTR	NM_005339	NP_005330	P61086	UBE2K_HUMAN	ubiquitin-conjugating enzyme E2K isoform 1	82					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						AATATGGCATCCTAATATTAG	0.338000													8	94					0	0	0.000274275	0	0
UGT2B15	7366	broad.mit.edu	37	4	69512977	69512977	+	Missense_Mutation	SNP	C	T	T	rs146368165	byFrequency	TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:69512977C>T	uc011cal.1	-	6	1476	c.1438G>A	c.(1438-1440)GCA>ACA	p.A480T		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	480					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TTGTGAGCTGCGACTCGAAGG	0.478000													12	93					0	0	6.40141e-05	0	0
ENAM	10117	broad.mit.edu	37	4	71507955	71507955	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:71507955G>A	uc011caw.1	+	9	1093	c.812G>A	c.(811-813)GGA>GAA	p.G271E		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	271					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AGCCCCACAGGAAACAGTACC	0.542000													6	39					0	0	3.59834e-05	0	0
ALB	213	broad.mit.edu	37	4	74274451	74274451	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:74274451C>T	uc003hgs.3	+	4	484	c.411C>T	c.(409-411)CCC>CCT	p.P137P	ALB_uc003hgw.3_Intron|ALB_uc011cbe.1_Intron|ALB_uc003hgt.3_Silent_p.P137P|ALB_uc010iii.2_Intron|ALB_uc003hgu.3_Intron|ALB_uc003hgv.3_Intron|ALB_uc011cbf.1_Silent_p.P27P|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'Flank	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	137	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CAAACCTCCCCCGATTGGTGA	0.398000													4	32					0	0	0.000602214	0	0
WDFY3	23001	broad.mit.edu	37	4	85731300	85731300	+	Silent	SNP	T	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:85731300T>G	uc003hpd.2	-	14	2493	c.2085A>C	c.(2083-2085)GCA>GCC	p.A695A	WDFY3_uc003hpf.2_Silent_p.A695A	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	695						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CATAGCGCATTGCTGCAGTCA	0.448000													15	58					0	0	0.000219431	0	0
ANK2	287	broad.mit.edu	37	4	114279286	114279286	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:114279286C>T	uc003ibe.3	+	38	9612	c.9512C>T	c.(9511-9513)TCA>TTA	p.S3171L	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.S473L|ANK2_uc011cgb.1_Missense_Mutation_p.S3186L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3138					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTTTCAGAATCAAAAGAAACA	0.478000													7	33					0	0	8.12818e-05	0	0
TRPC3	7222	broad.mit.edu	37	4	122846297	122846297	+	Missense_Mutation	SNP	C	T	T	rs148910203		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:122846297C>T	uc003ieg.2	-	3	1126	c.1052G>A	c.(1051-1053)CGA>CAA	p.R351Q	TRPC3_uc010inr.2_Missense_Mutation_p.R278Q|TRPC3_uc003ief.2_Missense_Mutation_p.R278Q|TRPC3_uc011cgl.1_Missense_Mutation_p.R15Q	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	266	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						TTCTGAGTCTCGGCAGAGATC	0.438000													15	73					0	0	0.000422831	0	0
TLL1	7092	broad.mit.edu	37	4	166916254	166916254	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:166916254G>A	uc003irh.1	+	5	1203	c.556G>A	c.(556-558)GAA>AAA	p.E186K	TLL1_uc011cjn.1_Missense_Mutation_p.E186K|TLL1_uc011cjo.1_Missense_Mutation_p.E10K	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	186	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GAGGCACTGGGAAAAGCACAC	0.448000													33	145					0	0	0.000409698	0	0
SPOCK3	50859	broad.mit.edu	37	4	167658662	167658662	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:167658662C>T	uc003iri.1	-	11	1238	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	SPOCK3_uc011cjp.1_Missense_Mutation_p.G323E|SPOCK3_uc011cjq.1_Missense_Mutation_p.G375E|SPOCK3_uc011cjr.1_Missense_Mutation_p.G246E|SPOCK3_uc003irj.1_Missense_Mutation_p.G363E|SPOCK3_uc011cjs.1_Missense_Mutation_p.G315E|SPOCK3_uc011cjt.1_Missense_Mutation_p.G274E|SPOCK3_uc011cju.1_Missense_Mutation_p.G259E|SPOCK3_uc011cjv.1_Missense_Mutation_p.G268E	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	366	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GACTTCATTTCCATATCTGTC	0.403000													25	126					0	0	0.000878237	0	0
DDX60	55601	broad.mit.edu	37	4	169204704	169204704	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:169204704G>A	uc003irp.2	-	13	1907	c.1615C>T	c.(1615-1617)CAA>TAA	p.Q539*		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	539							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TAAAACCGTTGGAAAACATGA	0.328000													15	48					0	0	0.000958276	0	0
SORBS2	8470	broad.mit.edu	37	4	186548051	186548051	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr4:186548051C>T	uc003iyl.2	-	12	1715	c.857G>A	c.(856-858)GGA>GAA	p.G286E	SORBS2_uc003iyh.2_Missense_Mutation_p.G537E|SORBS2_uc011ckw.1_Missense_Mutation_p.G374E|SORBS2_uc003iyi.2_Missense_Mutation_p.G444E|SORBS2_uc011ckx.1_Missense_Mutation_p.G379E|SORBS2_uc003iyk.2_Missense_Mutation_p.G357E|SORBS2_uc003iym.2_Missense_Mutation_p.G386E|SORBS2_uc003iyn.1_Missense_Mutation_p.G404E|SORBS2_uc011cky.1_Missense_Mutation_p.G349E|SORBS2_uc011cku.1_Missense_Mutation_p.G205E|SORBS2_uc011ckv.1_Missense_Mutation_p.G190E|SORBS2_uc003iyd.2_Missense_Mutation_p.G512E|SORBS2_uc003iye.2_Missense_Mutation_p.G386E|SORBS2_uc003iya.2_Missense_Mutation_p.G333E|SORBS2_uc003iyb.2_Missense_Mutation_p.G286E|SORBS2_uc003iyc.2_Missense_Mutation_p.G266E|SORBS2_uc003iyg.2_Missense_Mutation_p.G400E|SORBS2_uc003iyf.2_Missense_Mutation_p.G349E|SORBS2_uc003iyo.1_Missense_Mutation_p.G262E	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	286						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		GGTGCTTGATCCTGGGAGGTC	0.512000													15	91					0	0	0.000308642	0	0
SEMA5A	9037	broad.mit.edu	37	5	9154652	9154652	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:9154652C>T	uc003jek.2	-	12	2141	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	477	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						ACCACGTGCTCCCGCAGGCCC	0.612000													6	48					0	0	8.12818e-05	0	0
Unknown	0	broad.mit.edu	37	5	17354341	17354341	+	RNA	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:17354341C>T	uc003jfy.2	-	1		c.388G>A			uc003jfz.2_RNA					full-length cDNA clone CS0DC022YF01 of Neuroblastoma Cot 25-normalized of Homo sapiens (human).																		TCAGCATGTTCCCTCTCCTCA	0.483000													21	52					0	0	0.000175454	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33658378	33658378	+	Silent	SNP	T	C	C			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:33658378T>C	uc003jia.1	-	7	1264	c.1101A>G	c.(1099-1101)TCA>TCG	p.S367S	ADAMTS12_uc010iuq.1_Silent_p.S367S	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	367	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GACACATTCCTGAAAGGTGAG	0.517000										HNSCC(64;0.19)			4	127					0	0	0.00024832	0	0
C1QTNF3	114899	broad.mit.edu	37	5	34028868	34028868	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:34028868G>A	uc003jin.2	-	4	559	c.472C>T	c.(472-474)CCA>TCA	p.P158S	C1QTNF3_uc003jim.2_Missense_Mutation_p.P38S|C1QTNF3_uc003jio.2_Missense_Mutation_p.P231S	NM_030945	NP_112207	Q9BXJ4	C1QT3_HUMAN	C1q and tumor necrosis factor related protein 3	158	C1q.					collagen					0	all_lung(31;0.0207)					CCTGATACTGGGGCCCCAAAT	0.333000													7	42					0	0	0.000442599	0	0
AGXT2	64902	broad.mit.edu	37	5	34998865	34998865	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:34998865G>A	uc003jjf.2	-	14	1583	c.1504C>T	c.(1504-1506)CGT>TGT	p.R502C	AGXT2_uc003jje.1_Missense_Mutation_p.R155C|AGXT2_uc011com.1_Missense_Mutation_p.R427C	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	502					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	AAGGCAGAACGAAATACTTCT	0.378000													10	65					0	0	0.000673444	0	0
OSMR	9180	broad.mit.edu	37	5	38886238	38886238	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:38886238G>A	uc003jln.1	+	7	1304	c.937G>A	c.(937-939)GAA>AAA	p.E313K	OSMR_uc003jlm.1_Missense_Mutation_p.E313K	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	313	Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACTCATAGCTGAAAATTACTT	0.393000													13	70					0	0	0.000308642	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64511225	64511225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:64511225G>A	uc003jtp.2	-	19	3176	c.2362C>T	c.(2362-2364)CAT>TAT	p.H788Y	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.H409Y	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	788	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CTCTTGTAATGAAAAGCTGTC	0.393000													9	55					0	0	0.000442599	0	0
PIK3R1	5295	broad.mit.edu	37	5	67575450	67575450	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:67575450G>A	uc003jva.2	+	5	1083	c.523G>A	c.(523-525)GAA>AAA	p.E175K	PIK3R1_uc003jvb.2_Missense_Mutation_p.E175K	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	175	Rho-GAP.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CGTGGACTTGGAAATGATCGA	0.383000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			10	61					0	0	6.40141e-05	0	0
MAP1B	4131	broad.mit.edu	37	5	71494538	71494538	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:71494538C>T	uc003kbw.3	+	5	5597	c.5356C>T	c.(5356-5358)CCA>TCA	p.P1786S	MAP1B_uc010iyw.1_Missense_Mutation_p.P1803S|MAP1B_uc010iyx.1_Missense_Mutation_p.P1660S|MAP1B_uc010iyy.1_Missense_Mutation_p.P1660S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1786						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGATATCTCTCCACTCACCCC	0.448000													9	50					0	0	0.000274275	0	0
PDE8B	8622	broad.mit.edu	37	5	76707543	76707543	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:76707543A>G	uc003kfa.2	+	15	1618	c.1573A>G	c.(1573-1575)AAG>GAG	p.K525E	PDE8B_uc003kfb.2_Missense_Mutation_p.K505E|PDE8B_uc003kfc.2_Missense_Mutation_p.K470E|PDE8B_uc003kfd.2_Missense_Mutation_p.K478E|PDE8B_uc003kfe.2_Missense_Mutation_p.K428E	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	525					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		TGTGTTTACTAAGAGTAAGTT	0.413000													68	321					0	0	0.000781405	0	0
GPR98	84059	broad.mit.edu	37	5	90072347	90072347	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:90072347C>T	uc003kju.2	+	61	12577	c.12481C>T	c.(12481-12483)CTC>TTC	p.L4161F	GPR98_uc003kjt.2_Missense_Mutation_p.L1867F	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4161	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAGGCACATCCTCATTGGGGA	0.403000													8	49					0	0	0.000274275	0	0
CAMK4	814	broad.mit.edu	37	5	110819937	110819937	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:110819937G>A	uc011cvj.1	+	12	1294	c.1195G>A	c.(1195-1197)GCC>ACC	p.A399T	CAMK4_uc003kpf.2_Missense_Mutation_p.A399T|CAMK4_uc010jbv.2_Missense_Mutation_p.A202T|CAMK4_uc003kpg.2_Missense_Mutation_p.A90T	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	399					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		GAAGGTGCAAGCCTTAGAGAA	0.512000													8	35					0	0	0.000274275	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222821	140222821	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:140222821G>A	uc003lhs.2	+	1	1915	c.1915G>A	c.(1915-1917)GAA>AAA	p.E639K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.E639K	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	639	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCCTGGACGAAGCGGACTC	0.647000													24	77					0	0	0.000720815	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480627	140480627	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:140480627G>A	uc003lio.2	+	1	394	c.394G>A	c.(394-396)GTA>ATA	p.V132I	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	132	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATTCTCCGGTATTCTTTGA	0.393000													18	73					0	0	0.000958276	0	0
SLC36A2	153201	broad.mit.edu	37	5	150726974	150726974	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr5:150726974G>A	uc003lty.2	-	1	178	c.48C>T	c.(46-48)ATC>ATT	p.I16I	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Silent_p.I16I|SLC36A2_uc011dct.1_Silent_p.I16I	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	16	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTCCAATTTGATGGCAACGG	0.493000													27	150					0	0	0.000227799	0	0
STK19	8859	broad.mit.edu	37	6	31940123	31940123	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:31940123G>A	uc003nyv.2	+	2	393	c.265G>A	c.(265-267)GAC>AAC	p.D89N	DOM3Z_uc003nyo.1_5'Flank|DOM3Z_uc003nyp.1_5'Flank|DOM3Z_uc003nyq.1_5'Flank|DOM3Z_uc003nyr.1_5'Flank|DOM3Z_uc003nys.1_5'Flank|DOM3Z_uc010jtl.1_5'Flank|STK19_uc003nyt.2_Missense_Mutation_p.D46N|DOM3Z_uc003nyu.1_5'Flank|STK19_uc011dow.1_Missense_Mutation_p.D89N|STK19_uc011dox.1_Missense_Mutation_p.D46N|STK19_uc003nyw.2_Missense_Mutation_p.D89N|STK19_uc010jtn.1_RNA	NM_032454	NP_115830	P49842	STK19_HUMAN	serine/threonine kinase 19 isoform 2	89			D -> N (in a metastatic melanoma sample; somatic mutation).			nucleus	ATP binding|protein binding|protein serine/threonine kinase activity	p.D89N(2)		skin(4)	4						TGCGCCGGAAGACCCTATTTT	0.582000													10	55					0	0	0.000151284	0	0
ZNF76	7629	broad.mit.edu	37	6	35258133	35258133	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:35258133C>T	uc003oki.1	+	6	728	c.523C>T	c.(523-525)CTC>TTC	p.L175F	ZNF76_uc011dsy.1_Missense_Mutation_p.L175F|ZNF76_uc011dsz.1_Missense_Mutation_p.L175F|ZNF76_uc003okj.1_Missense_Mutation_p.L175F	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	175	C2H2-type 1.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGTGGGCGTCTCTACACCAC	0.532000													24	186					0	0	0.000878237	0	0
GFRAL	389400	broad.mit.edu	37	6	55264062	55264062	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:55264062C>T	uc003pcm.1	+	7	1123	c.1037C>T	c.(1036-1038)TCC>TTC	p.S346F		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	346	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GGATTTCATTCCCCCTTCAAT	0.284000													7	28					0	0	0.000274275	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905118	73905118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:73905118C>T	uc003pgk.2	+	14	3127	c.2780C>T	c.(2779-2781)CCT>CTT	p.P927L	KCNQ5_uc011dyh.1_Missense_Mutation_p.P946L|KCNQ5_uc011dyi.1_Missense_Mutation_p.P937L|KCNQ5_uc010kat.2_Missense_Mutation_p.P918L|KCNQ5_uc011dyj.1_Missense_Mutation_p.P817L|KCNQ5_uc011dyk.1_Missense_Mutation_p.P677L	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	927					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CTCAGCTTGCCTCATGTCAAA	0.423000													15	66					0	0	0.000219431	0	0
EPHA7	2045	broad.mit.edu	37	6	93967240	93967240	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:93967240C>T	uc003poe.2	-	12	2353	c.2112G>A	c.(2110-2112)GGG>GGA	p.G704G	EPHA7_uc003pof.2_Silent_p.G699G|EPHA7_uc011eac.1_Silent_p.G700G	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	704	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGACTGGTTTCCCTAAAATTA	0.368000													8	53					0	0	0.000157383	0	0
FRK	2444	broad.mit.edu	37	6	116289877	116289877	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:116289877G>A	uc003pwi.1	-	3	939	c.492C>T	c.(490-492)CAC>CAT	p.H164H		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	164	SH2.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		TAATTCTGTAGTGTTTTACAA	0.363000													13	72					0	0	0.000219431	0	0
CLVS2	134829	broad.mit.edu	37	6	123319073	123319073	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:123319073G>A	uc003pzi.1	+	2	1020	c.151G>A	c.(151-153)GAT>AAT	p.D51N		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	51					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GCGCACGGATGATGCCTTCAT	0.557000													12	58					0	0	0.00010058	0	0
PDE10A	10846	broad.mit.edu	37	6	165756929	165756929	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:165756929G>A	uc003qun.2	-	20	2259	c.2018C>T	c.(2017-2019)CCC>CTC	p.P673L	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.P603L|PDE10A_uc003quo.2_Missense_Mutation_p.P683L	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	673					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TTTTGTAACGGGCCACAGTTT	0.388000													9	55					0	0	0.000274275	0	0
CCR6	1235	broad.mit.edu	37	6	167550187	167550187	+	Nonsense_Mutation	SNP	C	T	T	rs139697820		TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:167550187C>T	uc003qvl.2	+	13	2945	c.469C>T	c.(469-471)CGA>TGA	p.R157*	CCR6_uc010kkm.2_Nonsense_Mutation_p.R157*|CCR6_uc003qvn.3_Nonsense_Mutation_p.R157*|CCR6_uc003qvm.3_Nonsense_Mutation_p.R157*	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	157	Cytoplasmic (Potential).				cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		ATTCCGGCTCCGATCCAGAAC	0.488000													12	55					0	0	0.00010058	0	0
KIF25	3834	broad.mit.edu	37	6	168443323	168443323	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:168443323G>A	uc003qwk.1	+	8	1174	c.912G>A	c.(910-912)GGG>GGA	p.G304G	KIF25_uc003qwl.1_Intron	NM_030615	NP_085118	Q9UIL4	KIF25_HUMAN	kinesin family member 25 isoform 1	304					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(1)|pancreas(1)	2		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCGTCCTGGGGGCTTTGTTGG	0.657000													11	86					0	0	6.40141e-05	0	0
MMD2	221938	broad.mit.edu	37	7	4947052	4947052	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:4947052G>A	uc003sno.3	-	7	984	c.788C>T	c.(787-789)ACC>ATC	p.T263I	MMD2_uc003snl.1_Intron|MMD2_uc003snn.3_Missense_Mutation_p.T239I|MMD2_uc010ksq.2_3'UTR	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	263	Extracellular (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		GGTCTGCAGGGTGCTGGGCAG	0.542000													16	70					0	0	0.000175454	0	0
PHF14	9678	broad.mit.edu	37	7	11101640	11101640	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:11101640A>G	uc003sry.1	+	16	3017	c.2582A>G	c.(2581-2583)AAG>AGG	p.K861R	PHF14_uc011jxi.1_Missense_Mutation_p.K576R|PHF14_uc003srz.2_Missense_Mutation_p.K861R|PHF14_uc011jxj.1_Missense_Mutation_p.K576R	NM_014660	NP_055475	O94880	PHF14_HUMAN	PHD finger protein 14 isoform 2	861							zinc ion binding			kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TTGCAAAAGAAGCCCAAGGCT	0.368000													3	18					0	0	6.4e-05	0	0
ETV1	2115	broad.mit.edu	37	7	13949261	13949261	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:13949261G>A	uc011jxq.1	-	11	1675	c.936C>T	c.(934-936)TTC>TTT	p.F312F	ETV1_uc011jxn.1_Silent_p.F272F|ETV1_uc011jxo.1_Silent_p.F209F|ETV1_uc011jxp.1_Silent_p.F254F|ETV1_uc003ssw.3_Silent_p.F289F|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.F294F|ETV1_uc011jxs.1_Silent_p.F294F|ETV1_uc010ktv.2_Missense_Mutation_p.S181L	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	312					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						ACCTACCATCGAATTTTTCTG	0.383000			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								16	136					0	0	0.000958276	0	0
HOXA4	3201	broad.mit.edu	37	7	27169083	27169084	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:27169083_27169084GG>AA	uc003sym.3	-	2	770_771	c.723_724CC>TT	c.(721-726)ACCCGG>ACTTGG	p.R242W	HOXA3_uc003syk.2_5'Flank	NM_002141	NP_002132	Q00056	HXA4_HUMAN	homeobox A4	242	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CGGCGCCGCCGGGTCAGGTATC	0.574000													9	62					0	0	6.4e-05	0	0
JAZF1	221895	broad.mit.edu	37	7	27880461	27880461	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:27880461C>T	uc003szn.2	-	4	652	c.411G>A	c.(409-411)GTG>GTA	p.V137V	JAZF1_uc003szm.2_Silent_p.V73V	NM_175061	NP_778231	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	137					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131						CCTCATAGTCCACCTCCTCCT	0.582000			T	SUZ12	endometrial stromal tumours								34	257					0	0	0.000191422	0	0
POM121L12	285877	broad.mit.edu	37	7	53103832	53103832	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:53103832G>A	uc003tpz.2	+	1	484	c.468G>A	c.(466-468)CAG>CAA	p.Q156Q		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	156											0						CCCCTGGACAGAGAgcccgcc	0.597000													5	16					0	0	0.000602214	0	0
CCDC146	57639	broad.mit.edu	37	7	76889513	76889513	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:76889513G>A	uc003uga.2	+	8	1073	c.946G>A	c.(946-948)GAA>AAA	p.E316K	CCDC146_uc010ldp.2_Missense_Mutation_p.E62K	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	316	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				CAAGCTATTGGAATTAGCCAG	0.313000													10	46					0	0	6.40141e-05	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86522373	86522373	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:86522373C>T	uc011kha.1	-	20	2914	c.2729G>A	c.(2728-2730)GGA>GAA	p.G910E	KIAA1324L_uc003uif.1_Missense_Mutation_p.G670E|KIAA1324L_uc011kgz.1_Missense_Mutation_p.G796E|KIAA1324L_uc003uie.2_Missense_Mutation_p.G743E	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	910	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CAAAGAAATTCCTTTAATGCA	0.398000													17	150					0	0	0.000375601	0	0
SLC25A13	10165	broad.mit.edu	37	7	95761116	95761117	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:95761116_95761117GG>AA	uc003uof.3	-	15	1720_1721	c.1529_1530CC>TT	c.(1528-1530)TCC>TTT	p.S510F	SLC25A13_uc003uog.3_Missense_Mutation_p.S511F|SLC25A13_uc011kik.1_Missense_Mutation_p.S402F	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	510	Solcar 2.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	CATTTGCAAAGGAAGCCTTCAC	0.515000													9	35					0	0	6.4e-05	0	0
FBXO24	26261	broad.mit.edu	37	7	100189493	100189493	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:100189493C>T	uc003uvm.1	+	4	819	c.526C>T	c.(526-528)CGC>TGC	p.R176C	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.R162C|FBXO24_uc003uvn.1_5'UTR|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.R214C|FBXO24_uc011kka.1_Missense_Mutation_p.R164C	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	176						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GCGGGCCTGTCGCTATGTTGT	0.473000													11	55					0	0	6.40141e-05	0	0
ZAN	7455	broad.mit.edu	37	7	100361534	100361534	+	Silent	SNP	A	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:100361534A>G	uc003uwj.2	+	21	4257	c.4092A>G	c.(4090-4092)CCA>CCG	p.P1364P	ZAN_uc003uwk.2_Silent_p.P1364P|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1364	VWFD 1.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCATGGCCCATTTGAGTATG	0.592000													6	79					0	0	3.59834e-05	0	0
MUC17	140453	broad.mit.edu	37	7	100678178	100678178	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:100678178C>T	uc003uxp.1	+	3	3534	c.3481C>T	c.(3481-3483)CCG>TCG	p.P1161S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1161	Extracellular (Potential).|59 X approximate tandem repeats.|17.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGGAACCACTCCGTTAGCAAG	0.522000													42	194					0	0	0.000319135	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839230	100839230	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:100839230G>A	uc003uyc.2	-	7	1190	c.1023C>T	c.(1021-1023)ATC>ATT	p.I341I	MOGAT3_uc010lhr.2_Silent_p.L274L	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	341					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GCCAGGCCTAGATGAAGGTGA	0.582000													9	66					0	0	0.000442599	0	0
ASB15	142685	broad.mit.edu	37	7	123277012	123277012	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:123277012G>A	uc003vku.1	+	12	2036	c.1744G>A	c.(1744-1746)GGA>AGA	p.G582R	ASB15_uc003vkw.1_Missense_Mutation_p.G582R	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	582					intracellular signal transduction					skin(2)|lung(1)	3						TGATCTCTATGGACAAGAGCT	0.333000													10	53					0	0	0.000673444	0	0
GRM8	2918	broad.mit.edu	37	7	126249460	126249460	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:126249460C>T	uc003vlr.2	-	7	1761	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.E484K|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	484	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ACTTTGTACTCTGTGCTTTTG	0.403000										HNSCC(24;0.065)			24	112					0	0	0.000720815	0	0
PARP12	64761	broad.mit.edu	37	7	139757831	139757831	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:139757831C>T	uc003vvl.1	-	2	1204	c.330G>A	c.(328-330)AAG>AAA	p.K110K	PARP12_uc003vvk.1_5'Flank|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	110	C3H1-type 1.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					TCCTACAGTTCTTCCTGCAAA	0.299000													8	76					0	0	0.000442599	0	0
JHDM1D	80853	broad.mit.edu	37	7	139796708	139796708	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:139796708G>A	uc003vvm.2	-	16	2160	c.2156C>T	c.(2155-2157)CCA>CTA	p.P719L	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	719					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					CCTTTTAATTGGAATTTCACT	0.303000													9	47					0	0	0.00010058	0	0
DENND2A	27147	broad.mit.edu	37	7	140301949	140301949	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:140301949C>T	uc010lnj.2	-	1	394	c.249G>A	c.(247-249)AGG>AGA	p.R83R	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.R83R|DENND2A_uc003vvw.2_Silent_p.R83R|DENND2A_uc003vvx.2_Silent_p.R83R	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	83										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CATCACTACTCCTCCTCTCCA	0.537000													12	72					0	0	0.00010058	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				14	60					0	0	0.000308642	0	0
PRSS1	5644	broad.mit.edu	37	7	142460296	142460296	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:142460296G>A	uc003wak.2	+	4	486	c.469G>A	c.(469-471)GAG>AAG	p.E157K	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.E97K	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	157	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CTACCCAGACGAGCTGCAGTG	0.507000									Hereditary_Pancreatitis				24	234					0	0	0.000227799	0	0
OR2A12	346525	broad.mit.edu	37	7	143792740	143792740	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:143792740C>T	uc011kty.1	+	1	540	c.540C>T	c.(538-540)ATC>ATT	p.I180I		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TCTGTCAAATCATGTCCGTAT	0.483000													16	96					0	0	0.000308642	0	0
C7orf33	202865	broad.mit.edu	37	7	148288069	148288069	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr7:148288069C>T	uc003wew.2	+	1	413	c.52C>T	c.(52-54)CCA>TCA	p.P18S		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	18										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CTGGAGACTTCCAGGCCCCCA	0.572000													12	45					0	0	0.000151284	0	0
EBF2	64641	broad.mit.edu	37	8	25708118	25708118	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:25708118C>T	uc003xes.1	-	15	1705	c.1688G>A	c.(1687-1689)GGA>GAA	p.G563E	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	563					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding	p.G563R(1)		ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		ACCTCTGAATCCATTTCCATT	0.488000													17	79					0	0	0.000175454	0	0
SNTG1	54212	broad.mit.edu	37	8	51442742	51442742	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:51442742C>T	uc010lxy.1	+	11	843	c.472C>T	c.(472-474)CCA>TCA	p.P158S	SNTG1_uc003xqs.1_Missense_Mutation_p.P158S|SNTG1_uc010lxz.1_Missense_Mutation_p.P158S|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	158					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TGCAGGTGCTCCAAGTGACCA	0.453000													13	51					0	0	0.000308642	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228854	57228854	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:57228854G>A	uc003xsy.1	-	2	691	c.53C>T	c.(52-54)TCA>TTA	p.S18L	SDR16C5_uc010lyk.1_Missense_Mutation_p.S18L|SDR16C5_uc010lyl.1_Missense_Mutation_p.S18L	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	18	Helical; (Potential).				detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ACTAAACAGTGATTTTCCTAA	0.418000													7	44					0	0	0.000274275	0	0
CYP7B1	9420	broad.mit.edu	37	8	65528505	65528505	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:65528505C>T	uc003xvj.2	-	3	797	c.593G>A	c.(592-594)GGA>GAA	p.G198E		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	198					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AATAACTTTTCCATATATAGT	0.328000													11	51					0	0	6.40141e-05	0	0
KCNB2	9312	broad.mit.edu	37	8	73849879	73849879	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:73849879G>A	uc003xzb.2	+	3	2877	c.2289G>A	c.(2287-2289)CAG>CAA	p.Q763Q		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	763	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CCCCCTCCCAGGGAGACAGAC	0.582000													14	70					0	0	0.000219431	0	0
PGCP	10404	broad.mit.edu	37	8	97892129	97892129	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:97892129G>T	uc003yhw.2	+	4	911	c.745G>T	c.(745-747)GGG>TGG	p.G249W	PGCP_uc010mbe.2_Missense_Mutation_p.G249W	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	249					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GGCTTCTCATGGGATCAAAAT	0.453000													8	199					0.000673444	0.00844079	0.000673444	1	0
GRHL2	79977	broad.mit.edu	37	8	102555576	102555576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:102555576C>T	uc010mbu.2	+	2	458	c.128C>T	c.(127-129)CCC>CTC	p.P43L	GRHL2_uc010mbt.1_Missense_Mutation_p.P43L|GRHL2_uc011lhi.1_Missense_Mutation_p.P43L	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	43	Transcription activation.					cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TTGGAGAATCCCCTGACAGCA	0.542000													8	85					0	0	0.000274275	0	0
ANGPT1	284	broad.mit.edu	37	8	108315569	108315569	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:108315569C>T	uc003ymn.2	-	5	1303	c.835G>A	c.(835-837)GAA>AAA	p.E279K	ANGPT1_uc011lhv.1_Missense_Mutation_p.E79K|ANGPT1_uc003ymo.2_Missense_Mutation_p.E278K|ANGPT1_uc003ymp.3_Missense_Mutation_p.E78K	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	279	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GGTTTCTCTTCCTCTCTTTTT	0.308000													12	78					0	0	0.00010058	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457018	110457018	+	Silent	SNP	G	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:110457018G>T	uc003yne.2	+	38	5024	c.4920G>T	c.(4918-4920)CTG>CTT	p.L1640L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1640	Extracellular (Potential).|IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCTACAACCTGGGCACTGCTA	0.403000										HNSCC(38;0.096)			51	213					3.31993e-32	4.29936e-31	0.000781405	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110457481	110457481	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:110457481G>A	uc003yne.2	+	38	5487	c.5383G>A	c.(5383-5385)GAA>AAA	p.E1795K		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1795	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGAGGTTAATGAAAACAACAT	0.423000										HNSCC(38;0.096)			13	81					0	0	0.000308642	0	0
COL14A1	7373	broad.mit.edu	37	8	121381647	121381647	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:121381647G>A	uc003yox.2	+	47	5499	c.5234G>A	c.(5233-5235)GGG>GAG	p.G1745E	COL14A1_uc003yoz.2_Missense_Mutation_p.G710E	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1745	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGTCATCTGGGGGTTCCTGGA	0.592000													15	43					0	0	0.000566183	0	0
FAM83A	84985	broad.mit.edu	37	8	124195487	124195487	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:124195487G>A	uc003ypv.2	+	2	2405	c.391G>A	c.(391-393)GAA>AAA	p.E131K	FAM83A_uc003ypw.2_Missense_Mutation_p.E131K|FAM83A_uc003ypy.2_Missense_Mutation_p.E131K|FAM83A_uc003ypx.2_Missense_Mutation_p.E131K|FAM83A_uc003ypz.2_Missense_Mutation_p.E131K	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	131										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CTACCTGAAGGAAAAATCCAG	0.612000													9	63					0	0	0.000274275	0	0
FER1L6	654463	broad.mit.edu	37	8	125025757	125025757	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:125025757C>T	uc003yqw.2	+	15	2114	c.1908C>T	c.(1906-1908)TTC>TTT	p.F636F	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	636	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCAGTGACTTCATCAGTCGGA	0.453000													11	52					0	0	6.40141e-05	0	0
SLC45A4	57210	broad.mit.edu	37	8	142221565	142221565	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:142221565C>T	uc003ywd.1	-	8	2681	c.2373G>A	c.(2371-2373)CCG>CCA	p.P791P	SLC45A4_uc003ywc.1_3'UTR|SLC45A4_uc010meq.1_3'UTR	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	Error:Variant_position_missing_in_Q5BKX6_after_alignment					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CCAGGCCCCCCGGACCAGCCT	0.647000													10	77					0	0	0.000442599	0	0
PTP4A3	11156	broad.mit.edu	37	8	142437169	142437170	+	Splice_Site	DNP	GG	TA	TA			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:142437169_142437170GG>TA	uc003ywg.1	+	3	663	c.329_splice	c.e3+1	p.R110_splice	PTP4A3_uc003ywh.1_Splice_Site_p.R110_splice|PTP4A3_uc010met.1_Intron	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3							early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			GGCCTGGGCCGGTGAGTGTCGG	0.653000													9	78					0	0	6.4e-05	0	0
EPPK1	83481	broad.mit.edu	37	8	144946534	144946534	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:144946534G>A	uc003zaa.1	-	1	901	c.888C>T	c.(886-888)GGC>GGT	p.G296G		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	296	Plectin 6.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTTCTTGTGGCCTTCGGGCA	0.687000													13	62					0	0	0.000422831	0	0
OPLAH	26873	broad.mit.edu	37	8	145106331	145106331	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr8:145106331C>T	uc003zar.3	-	28	3845	c.3763G>A	c.(3763-3765)GAC>AAC	p.D1255N		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1255							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	TCCTCCGGGTCCCCATAGCCA	0.741000													7	17					0	0	0.000274275	0	0
SH3GL2	6456	broad.mit.edu	37	9	17786438	17786438	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:17786438G>A	uc003zna.2	+	4	535	c.247G>A	c.(247-249)GGG>AGG	p.G83R	SH3GL2_uc011lmx.1_Missense_Mutation_p.G48R|SH3GL2_uc011lmy.1_Missense_Mutation_p.G36R	NM_003026	NP_003017	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	83	Required for dimerization upon membrane association (By similarity).|BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			skin(1)	1				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		CCAGGAGAAGGGGCCAGGCTA	0.502000													13	67					0	0	0.000308642	0	0
TRPM6	140803	broad.mit.edu	37	9	77417015	77417015	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:77417015C>T	uc004ajl.1	-	16	2046	c.1808G>A	c.(1807-1809)GGC>GAC	p.G603D	TRPM6_uc004ajk.1_Missense_Mutation_p.G598D|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_5'UTR	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	603	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTAAAGAAAGCCAGTAGACTC	0.423000													10	37					0	0	0.000673444	0	0
PRUNE2	158471	broad.mit.edu	37	9	79244197	79244197	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:79244197G>A	uc010mpk.2	-	16	9184	c.9060C>T	c.(9058-9060)TTC>TTT	p.F3020F	PRUNE2_uc011lsk.1_Silent_p.F269F|PRUNE2_uc011lsl.1_Silent_p.F284F|PRUNE2_uc011lsm.1_Silent_p.F285F|PRUNE2_uc004akj.3_Silent_p.F474F	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	3020	CRAL-TRIO.				apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TTTTACTGCTGAATTTTGAAC	0.328000													5	19					0	0	3.59834e-05	0	0
FAM120A	23196	broad.mit.edu	37	9	96278434	96278434	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:96278434C>T	uc004atw.2	+	7	1326	c.1301C>T	c.(1300-1302)TCC>TTC	p.S434F	FAM120A_uc004atv.2_Missense_Mutation_p.S434F|FAM120A_uc004atx.2_Missense_Mutation_p.S216F|FAM120A_uc004aty.2_Missense_Mutation_p.S215F|FAM120A_uc004atz.2_Missense_Mutation_p.S83F|FAM120A_uc010mrf.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	434						cytoplasm|plasma membrane	RNA binding				0						TATGAGCGGTCCTCGCCCATC	0.597000													6	37					0	0	0.000157383	0	0
OR13F1	138805	broad.mit.edu	37	9	107267206	107267206	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:107267206C>T	uc011lvm.1	+	1	663	c.663C>T	c.(661-663)ATC>ATT	p.I221I		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ATGCATTTATCCTCGCCAGTA	0.473000													6	110					0	0	3.59834e-05	0	0
OR13C8	138802	broad.mit.edu	37	9	107331655	107331655	+	Silent	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:107331655C>T	uc011lvo.1	+	1	207	c.207C>T	c.(205-207)CTC>CTT	p.L69L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTCCTTCCTCGACGTTTGCT	0.428000													14	169					0	0	0.000308642	0	0
OR13C8	138802	broad.mit.edu	37	9	107332092	107332092	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:107332092C>T	uc011lvo.1	+	1	644	c.644C>T	c.(643-645)TCC>TTC	p.S215F		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTAGTAATTTCCATCTCTTAC	0.418000													26	78					0	0	0.000147802	0	0
TXNDC8	255220	broad.mit.edu	37	9	113096559	113096559	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:113096559G>A	uc004bes.2	-	2	115	c.66C>T	c.(64-66)CTC>CTT	p.L22L	TXNDC8_uc011lwl.1_Silent_p.L22L	NM_001003936	NP_001003936	Q6A555	TXND8_HUMAN	thioredoxin domain containing 8	22	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	Golgi apparatus	electron carrier activity|protein disulfide oxidoreductase activity				0						GAACCACTGCGAGTTTGTGTC	0.368000													6	33					0	0	0.000157383	0	0
DBC1	1620	broad.mit.edu	37	9	121929846	121929846	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr9:121929846G>A	uc004bkc.2	-	8	2258	c.1802C>T	c.(1801-1803)ACT>ATT	p.T601I		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	601					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CAGCAAAAGAGTCCAGTTGTA	0.547000													22	87					0	0	0.00047179	0	0
MXRA5	25878	broad.mit.edu	37	X	3229204	3229204	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:3229204G>A	uc004crg.3	-	7	7197	c.7040C>T	c.(7039-7041)ACC>ATC	p.T2347I		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2347	Ig-like C2-type 8.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTTCCGGATGGTGGCGGGCGC	0.567000													21	32					0	0	0.00047179	0	0
CNKSR2	22866	broad.mit.edu	37	X	21624974	21624974	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:21624974G>A	uc004czx.1	+	19	2158	c.2122G>A	c.(2122-2124)GAT>AAT	p.D708N	CNKSR2_uc004czw.2_Missense_Mutation_p.D708N|CNKSR2_uc011mjn.1_Missense_Mutation_p.D659N|CNKSR2_uc011mjo.1_Missense_Mutation_p.D678N|CNKSR2_uc004czy.2_Missense_Mutation_p.D300N	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	708					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						ACCCCCATATGATACATACCC	0.403000													18	25					0	0	0.000958276	0	0
KIF4A	24137	broad.mit.edu	37	X	69615626	69615626	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:69615626C>G	uc004dyg.2	+	21	2465	c.2338C>G	c.(2338-2340)CAA>GAA	p.Q780E	KIF4A_uc010nkw.2_Missense_Mutation_p.Q780E	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	780	Potential.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						AGATGTGGCTCAACTCAAAGA	0.433000													7	12					0	0	8.12818e-05	0	0
DRP2	1821	broad.mit.edu	37	X	100511121	100511121	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:100511121A>T	uc004egz.2	+	21	2630	c.2261A>T	c.(2260-2262)TAC>TTC	p.Y754F	DRP2_uc011mrh.1_Missense_Mutation_p.Y676F	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	754					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						GAGGACCAGTACCTGCTGCGG	0.577000													19	36					0	0	0.000229342	0	0
PDZD4	57595	broad.mit.edu	37	X	153069219	153069219	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:153069219G>A	uc004fiz.1	-	8	2149	c.1899C>T	c.(1897-1899)ACC>ACT	p.T633T	PDZD4_uc004fiy.1_Silent_p.T558T|PDZD4_uc004fix.2_Silent_p.T537T|PDZD4_uc004fja.1_Silent_p.T639T|PDZD4_uc011mze.1_Silent_p.T524T	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	633						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACGTAGCGGGTTCCGTCGC	0.706000													12	26					0	0	0.000151284	0	0
TKTL1	8277	broad.mit.edu	37	X	153524338	153524338	+	Silent	SNP	G	A	A			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chrX:153524338G>A	uc004fkg.2	+	1	312	c.126G>A	c.(124-126)ACG>ACA	p.T42T	TEX28_uc004fke.2_5'Flank|TEX28_uc004fkf.2_5'Flank|TEX28_uc010nut.1_5'Flank|TKTL1_uc011mzl.1_Silent_p.T42T|TKTL1_uc011mzm.1_Silent_p.T42T	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	42					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATGCTCCACGAGCTCCGGGT	0.617000													19	47					0	0	0.000375601	0	0
HCG4	54435	broad.mit.edu	37	6	29759128	29759129	+	RNA	INS	-	G	G			TCGA-EE-A2MG-06A-11D-A197-08	TCGA-EE-A2MG-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	625ea078-f2fa-4061-9b16-5eff81558723	18363141-4118-43b1-b80b-165b1b0456c2	g.chr6:29759128_29759129insG	uc003nns.2	-	1		c.1722_1723insC			uc010jrm.1_5'UTR|uc003nnt.2_5'Flank|uc011dma.1_5'Flank	NR_002139				Homo sapiens clone HCG IV.9 unknown mRNA.												0						TACCTTGTATTAGGAGATGTCC	0.441													3	3	---	---	---	---					
