Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CNKSR1	10256	broad.mit.edu	37	1	26507021	26507021	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr1:26507021C>G	uc001bln.3	+	2	188	c.130C>G	c.(130-132)CAA>GAA	p.Q44E	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.Q44E|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	44	SAM.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GCTCTGCCCCCAAAGCCTCGA	0.622													7	93	---	---	---	---	0	0	0.003080	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110033986	110033986	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr1:110033986C>G	uc001dxr.2	+	10	1816	c.1801C>G	c.(1801-1803)CTC>GTC	p.L601V	ATXN7L2_uc001dxs.2_Missense_Mutation_p.L228V|ATXN7L2_uc001dxt.2_Missense_Mutation_p.L104V|CYB561D1_uc010ovl.1_5'Flank|CYB561D1_uc010ovm.1_5'Flank|CYB561D1_uc001dxu.2_5'Flank|CYB561D1_uc001dxw.2_5'Flank|CYB561D1_uc010ovn.1_5'Flank|CYB561D1_uc010ovo.1_5'Flank|CYB561D1_uc009wfd.2_5'Flank|CYB561D1_uc010ovp.1_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	601										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTGTAGGGGCCTCTCGGCCAA	0.592													37	54	---	---	---	---	0	0	0.003755	0	0
FZD8	8325	broad.mit.edu	37	10	35929590	35929590	+	Missense_Mutation	SNP	C	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr10:35929590C>A	uc001iyz.1	-	1	773	c.768G>T	c.(766-768)CAG>CAT	p.Q256H		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	256	Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						AGTTAGCGATCTGGCCTGTCT	0.682													26	23	---	---	---	---	3.28513e-13	4.51705e-13	0.003954	1	0
CDH23	64072	broad.mit.edu	37	10	73537998	73537998	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr10:73537998A>G	uc001jrx.3	+	38	5497	c.5120A>G	c.(5119-5121)TAC>TGC	p.Y1707C		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1707	Cadherin 16.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CACGGCCGCTACACCCTGATC	0.607													5	60	---	---	---	---	0	0	0.000602	0	0
CARS	833	broad.mit.edu	37	11	3023813	3023813	+	Silent	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr11:3023813C>T	uc001lxh.2	-	20	2060	c.1986G>A	c.(1984-1986)AGG>AGA	p.R662R	CARS_uc009ydu.2_Intron|CARS_uc001lxe.2_Silent_p.R652R|CARS_uc001lxf.2_Silent_p.R745R|CARS_uc001lxg.2_Silent_p.R662R|CARS_uc010qxo.1_Silent_p.R745R|CARS_uc010qxp.1_Silent_p.R675R	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	662					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	CTTTCTTCTTCCTCTTCTCCT	0.557			T	ALK	ALCL								46	235	---	---	---	---	0	0	0.003610	0	0
BTBD10	84280	broad.mit.edu	37	11	13441034	13441034	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr11:13441034G>A	uc001mkz.2	-	4	814	c.557C>T	c.(556-558)ACT>ATT	p.T186I	BTBD10_uc010rcl.1_Missense_Mutation_p.T194I|BTBD10_uc001mla.2_Missense_Mutation_p.T170I|BTBD10_uc009ygn.2_RNA|BTBD10_uc010rcm.1_Missense_Mutation_p.T138I|BTBD10_uc010rcn.1_Missense_Mutation_p.T155I|BTBD10_uc009ygo.2_Missense_Mutation_p.T138I	NM_032320	NP_115696	Q9BSF8	BTBDA_HUMAN	K+ channel tetramerization protein	186	BTB.					nucleus					0				Epithelial(150;0.0214)		TGGCTGTGCAGTAAAAATGGA	0.284													3	55	---	---	---	---	0	0	0.004672	0	0
ATM	472	broad.mit.edu	37	11	108190727	108190727	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr11:108190727C>G	uc001pkb.1	+	44	6779	c.6394C>G	c.(6394-6396)CTA>GTA	p.L2132V	ATM_uc009yxr.1_Missense_Mutation_p.L2132V|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.L784V|ATM_uc001pkg.1_Missense_Mutation_p.L489V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2132	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTACAATGCTCTACAATCTCT	0.299			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			29	50	---	---	---	---	0	0	0.001786	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1949958	1949958	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr12:1949958G>A	uc001qjp.2	-	26	2729	c.2498C>T	c.(2497-2499)ACG>ATG	p.T833M	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.T697M|CACNA2D4_uc009zdr.1_RNA	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	833	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TGTGCTTGCCGTCACCACCAT	0.597													37	37	---	---	---	---	0	0	0.006230	0	0
NAP1L1	4673	broad.mit.edu	37	12	76444373	76444373	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr12:76444373G>A	uc001sxw.2	-	12	1409	c.997C>T	c.(997-999)CGT>TGT	p.R333C	NAP1L1_uc001sxv.2_Missense_Mutation_p.R291C|NAP1L1_uc001sxz.2_Missense_Mutation_p.R264C|NAP1L1_uc001sxx.2_Missense_Mutation_p.R333C|NAP1L1_uc001sxy.2_Missense_Mutation_p.R270C|NAP1L1_uc010sty.1_Missense_Mutation_p.R290C|NAP1L1_uc010stz.1_Missense_Mutation_p.R150C|NAP1L1_uc010sua.1_Missense_Mutation_p.R333C|NAP1L1_uc001syb.2_Missense_Mutation_p.R333C|NAP1L1_uc001sya.2_Missense_Mutation_p.R291C|NAP1L1_uc001syc.2_Missense_Mutation_p.R344C	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	333					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				GGGATTATACGCTCACGTAAA	0.343													15	20	---	---	---	---	0	0	0.002450	0	0
ATXN2	6311	broad.mit.edu	37	12	111893961	111893961	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr12:111893961T>A	uc001tsj.2	-	23	3778	c.3616A>T	c.(3616-3618)ACA>TCA	p.T1206S	ATXN2_uc001tsh.2_Missense_Mutation_p.T941S|ATXN2_uc001tsi.2_Missense_Mutation_p.T899S|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.T394S|ATXN2_uc001tsl.1_Missense_Mutation_p.T207S	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1206					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						GAGGCAGGTGTCATGGAGGGT	0.587													98	126	---	---	---	---	0	0	0.003610	0	0
OR11H12	440153	broad.mit.edu	37	14	19378084	19378084	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr14:19378084G>T	uc010tkp.1	+	1	491	c.491G>T	c.(490-492)TGG>TTG	p.W164L		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATACTGTGCTGGGTTTGTGGA	0.488													19	123	---	---	---	---	3.83957e-06	5.17166e-06	0.002780	1	0
MAP1A	4130	broad.mit.edu	37	15	43815344	43815344	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr15:43815344C>G	uc001zrt.2	+	4	2140	c.1673C>G	c.(1672-1674)CCA>CGA	p.P558R		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	558						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGAGATAAGCCATTCCCTCTA	0.537													53	48	---	---	---	---	0	0	0.003610	0	0
CCPG1	9236	broad.mit.edu	37	15	55664157	55664157	+	Silent	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr15:55664157A>G	uc002acv.1	-	6	705	c.540T>C	c.(538-540)GCT>GCC	p.A180A	CCPG1_uc002acy.2_Silent_p.A180A|CCPG1_uc002acu.1_Silent_p.A36A|CCPG1_uc002acw.1_5'UTR|CCPG1_uc002acx.2_Silent_p.A180A|CCPG1_uc010bfk.1_Silent_p.A180A|CCPG1_uc002acz.1_Silent_p.A180A	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	180	Cytoplasmic (Potential).|Poly-Arg.|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		TCTTCTTCCTAGCACGGCGTC	0.433													3	46	---	---	---	---	0	0	0.000248	0	0
DNAH3	55567	broad.mit.edu	37	16	20975172	20975172	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr16:20975172C>T	uc010vbe.1	-	53	10034	c.10034G>A	c.(10033-10035)CGC>CAC	p.R3345H	DNAH3_uc010vbd.1_Missense_Mutation_p.R780H	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3345					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTACTTGATGCGCAGATTCAG	0.488													52	86	---	---	---	---	0	0	0.003610	0	0
LCMT1	51451	broad.mit.edu	37	16	25182127	25182127	+	Splice_Site	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr16:25182127G>A	uc002dnx.1	+	9	1042	c.884_splice	c.e9+1	p.R295_splice	LCMT1_uc002dny.1_Splice_Site_p.R240_splice|LCMT1_uc002dnz.1_Splice_Site_p.R195_splice|LCMT1_uc002doa.1_Splice_Site_p.R140_splice	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a								protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	AAGTGAGCAGGTATGGGGTTG	0.473													32	54	---	---	---	---	0	0	0.002096	0	0
KIAA1632	57724	broad.mit.edu	37	18	43519707	43519707	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr18:43519707T>C	uc002lbm.2	-	10	2058	c.1958A>G	c.(1957-1959)TAT>TGT	p.Y653C	KIAA1632_uc002lbo.1_Missense_Mutation_p.Y653C	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	653					autophagy						0						GTCACTTACATAACCAAGAGT	0.378													9	25	---	---	---	---	0	0	0.004482	0	0
ZNF532	55205	broad.mit.edu	37	18	56587101	56587101	+	Missense_Mutation	SNP	A	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr18:56587101A>T	uc002lho.2	+	4	2129	c.1582A>T	c.(1582-1584)AAC>TAC	p.N528Y	ZNF532_uc002lhp.2_Missense_Mutation_p.N526Y|ZNF532_uc010xeg.1_Missense_Mutation_p.N526Y|ZNF532_uc002lhr.2_Missense_Mutation_p.N526Y|ZNF532_uc002lhs.2_Missense_Mutation_p.N526Y	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TGCCAACCTTAACCTTTTGCC	0.542													4	45	---	---	---	---	0	0	0.000602	0	0
CDH19	28513	broad.mit.edu	37	18	64197108	64197108	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr18:64197108C>T	uc002lkc.1	-	9	1570	c.1432G>A	c.(1432-1434)GTT>ATT	p.V478I	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.V478I	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	478	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TTTTCACAAACATAAGTCTCA	0.313													27	27	---	---	---	---	0	0	0.002445	0	0
C19orf35	374872	broad.mit.edu	37	19	2276472	2276472	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr19:2276472G>A	uc002lvn.2	-	4	729	c.629C>T	c.(628-630)GCG>GTG	p.A210V	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	210										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCACGTCCGCCCCGGGCTT	0.706													4	22	---	---	---	---	0	0	0.000248	0	0
CYP4F11	57834	broad.mit.edu	37	19	16038119	16038119	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr19:16038119T>C	uc002nbu.2	-	5	464	c.428A>G	c.(427-429)AAG>AGG	p.K143R	CYP4F11_uc010eab.1_Missense_Mutation_p.K143R|CYP4F11_uc002nbt.2_Missense_Mutation_p.K143R	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	143					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						GCGGCTCCACTTGTCACCACC	0.537													69	73	---	---	---	---	0	0	0.003610	0	0
U2AF2	11338	broad.mit.edu	37	19	56166505	56166505	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr19:56166505A>G	uc002qlu.2	+	1	1090	c.35A>G	c.(34-36)AAC>AGC	p.N12S	U2AF2_uc002qlt.2_Missense_Mutation_p.N12S	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	12					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGGCAGCTCAACGAGAATAAA	0.682													8	34	---	---	---	---	0	0	0.006214	0	0
NLRP8	126205	broad.mit.edu	37	19	56467090	56467090	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr19:56467090G>A	uc002qmh.2	+	3	1737	c.1666G>A	c.(1666-1668)GGA>AGA	p.G556R	NLRP8_uc010etg.2_Missense_Mutation_p.G556R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	556						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTCTCACATGGGACTTTTCTT	0.463													31	37	---	---	---	---	0	0	0.002445	0	0
TTC27	55622	broad.mit.edu	37	2	33036256	33036256	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr2:33036256G>A	uc002rom.2	+	17	2395	c.2164G>A	c.(2164-2166)GGG>AGG	p.G722R	TTC27_uc010ymx.1_Missense_Mutation_p.G672R|TTC27_uc002ron.2_RNA	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	722							protein binding			central_nervous_system(1)	1						ATATGGAAATGGGCAGAGTGA	0.433													13	16	---	---	---	---	0	0	0.001855	0	0
PKP4	8502	broad.mit.edu	37	2	159519930	159519930	+	Silent	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr2:159519930C>T	uc002tzv.2	+	15	2810	c.2550C>T	c.(2548-2550)CTC>CTT	p.L850L	PKP4_uc002tzu.2_Silent_p.L850L|PKP4_uc002tzw.2_Silent_p.L850L|PKP4_uc002tzx.2_Silent_p.L507L|PKP4_uc002uaa.2_Silent_p.L702L|uc002uab.1_Intron|PKP4_uc002uac.2_Silent_p.L31L|PKP4_uc002uad.2_5'Flank	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	850	ARM 7.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						CAGGGTCTCTCCAGAACCTCT	0.453										HNSCC(62;0.18)			19	29	---	---	---	---	0	0	0.001882	0	0
CDK15	65061	broad.mit.edu	37	2	202744823	202744823	+	Silent	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr2:202744823C>T	uc002uyt.2	+	12	1180	c.1131C>T	c.(1129-1131)TCC>TCT	p.S377S	CDK15_uc002uys.2_Silent_p.S326S|CDK15_uc010ftn.1_Silent_p.S326S|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	377	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	ACCGCGTCTCCGCCCAGGAAG	0.488													7	65	---	---	---	---	0	0	0.003080	0	0
SULF2	55959	broad.mit.edu	37	20	46290580	46290580	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr20:46290580T>A	uc002xto.2	-	18	2761	c.2431A>T	c.(2431-2433)ATG>TTG	p.M811L	SULF2_uc002xtr.2_Missense_Mutation_p.M811L|SULF2_uc002xtq.2_Missense_Mutation_p.M811L|SULF2_uc010zyd.1_Missense_Mutation_p.M90L	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	811					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CTCAGCTCCATGAGCTGTACG	0.532													51	59	---	---	---	---	0	0	0.003610	0	0
THAP7	80764	broad.mit.edu	37	22	21356155	21356155	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr22:21356155G>A	uc002ztr.1	-	2	76	c.46C>T	c.(46-48)CGC>TGC	p.R16C	THAP7_uc002zts.1_Missense_Mutation_p.R16C|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	16	THAP-type.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CGCGTCTCGCGCGTGTCCCGT	0.697													4	2	---	---	---	---	0	0	0.000602	0	0
ZNRF3	84133	broad.mit.edu	37	22	29445437	29445437	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr22:29445437A>G	uc003aeg.2	+	8	1133	c.968A>G	c.(967-969)CAC>CGC	p.H323R	ZNRF3_uc003aeh.1_Missense_Mutation_p.H323R	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	423	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						CCACCCCTCCACCTGGACCAC	0.697													20	37	---	---	---	---	0	0	0.003330	0	0
CCDC39	339829	broad.mit.edu	37	3	180381672	180381672	+	Missense_Mutation	SNP	C	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr3:180381672C>G	uc010hxe.2	-	2	308	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	65	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTGAGAGCTCTTGCTTAACA	0.353													15	44	---	---	---	---	0	0	0.003163	0	0
SDAD1	55153	broad.mit.edu	37	4	76886950	76886950	+	Silent	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr4:76886950A>G	uc003hje.3	-	13	1190	c.1071T>C	c.(1069-1071)GCT>GCC	p.A357A	SDAD1_uc003hjf.3_Silent_p.A260A|SDAD1_uc011cbr.1_Silent_p.A320A	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	357					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ATGCTTGTGCAGCAAACAGAA	0.448													29	79	---	---	---	---	0	0	0.001786	0	0
HNRPDL	9987	broad.mit.edu	37	4	83350530	83350530	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr4:83350530G>A	uc003hmr.2	-	1	849	c.314C>T	c.(313-315)ACC>ATC	p.T105I	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.T105I	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	105					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				CGCAGTCCGGGTCGCGGCAGC	0.622													19	59	---	---	---	---	0	0	0.006122	0	0
AFF1	4299	broad.mit.edu	37	4	88035727	88035727	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr4:88035727C>T	uc003hqj.3	+	11	2128	c.1721C>T	c.(1720-1722)CCA>CTA	p.P574L	AFF1_uc011ccz.1_Missense_Mutation_p.P581L|AFF1_uc003hqk.3_Missense_Mutation_p.P574L|AFF1_uc011cda.1_Missense_Mutation_p.P212L	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	574						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCCCGGGCCCCACCCGAAGCC	0.592													6	10	---	---	---	---	0	0	0.001168	0	0
DDX60L	91351	broad.mit.edu	37	4	169374416	169374416	+	Silent	SNP	T	C	C			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr4:169374416T>C	uc003irq.3	-	8	1076	c.855A>G	c.(853-855)CTA>CTG	p.L285L	DDX60L_uc003irr.1_Silent_p.L285L|DDX60L_uc003irs.1_Silent_p.L12L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	285							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CCTGCAGGGATAGGCAATTAC	0.463													11	16	---	---	---	---	0	0	0.001855	0	0
CSNK1G3	1456	broad.mit.edu	37	5	122881412	122881412	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr5:122881412A>G	uc003ktm.2	+	2	774	c.55A>G	c.(55-57)AGT>GGT	p.S19G	CSNK1G3_uc003ktl.2_Missense_Mutation_p.S19G|CSNK1G3_uc003ktn.2_Missense_Mutation_p.S19G|CSNK1G3_uc003kto.2_Missense_Mutation_p.S19G|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Missense_Mutation_p.S19G	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	19					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		GGCACGACCTAGTGGTCGATC	0.403													3	26	---	---	---	---	0	0	0.004672	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114417	27114417	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr6:27114417C>T	uc003nix.1	-	1	203	c.161G>A	c.(160-162)GGC>GAC	p.G54D	HIST1H2AH_uc003niz.2_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080593	NP_542160	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	54					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGAGGAGATGCCGGTGTCGGG	0.582													5	214	---	---	---	---	0	0	0.000602	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41754716	41754716	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr6:41754716A>G	uc011duf.1	+	8	1252	c.1004A>G	c.(1003-1005)AAG>AGG	p.K335R	PRICKLE4_uc003ord.2_RNA|TOMM6_uc003org.2_RNA|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	over-expressed breast tumor protein	295						nucleus	zinc ion binding				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGTGATCCCAAGGACACCCCT	0.607											OREG0017435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	165	---	---	---	---	0	0	0.000602	0	0
MUC17	140453	broad.mit.edu	37	7	100679804	100679804	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr7:100679804G>A	uc003uxp.1	+	3	5160	c.5107G>A	c.(5107-5109)GCC>ACC	p.A1703T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1703	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|26.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AACACCGGTGGCCAGCTCTGC	0.478													23	289	---	---	---	---	0	0	0.006320	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				14	23	---	---	---	---	0	0	0.003163	0	0
KCNH2	3757	broad.mit.edu	37	7	150648922	150648922	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr7:150648922A>G	uc003wic.2	-	7	1572	c.1559T>C	c.(1558-1560)CTG>CCG	p.L520P	KCNH2_uc003wib.2_Missense_Mutation_p.L180P|KCNH2_uc011kux.1_Missense_Mutation_p.L424P|KCNH2_uc003wid.2_Missense_Mutation_p.L180P|KCNH2_uc003wie.2_Missense_Mutation_p.L520P	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	520	Extracellular (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CAGCCCGATCAGCTGGGGGAC	0.667													3	37	---	---	---	---	0	0	0.004672	0	0
PABPC1	26986	broad.mit.edu	37	8	101719214	101719214	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr8:101719214T>C	uc003yjs.1	-	10	1852	c.1348A>G	c.(1348-1350)ATG>GTG	p.M450V	PABPC1_uc011lhc.1_Missense_Mutation_p.M418V|PABPC1_uc011lhd.1_Missense_Mutation_p.M405V|PABPC1_uc003yjt.1_Missense_Mutation_p.M447V|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	450					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			GCACCGGGCATATTTTGGAAT	0.438													3	48	---	---	---	---	0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	X	47658045	47658045	+	IGR	SNP	A	G	G			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chrX:47658045A>G								LOC100133957 (138269 upstream) : ZNF81 (38256 downstream)																							ACTACATTATACAGTCCACTG	0.498													2	6	---	---	---	---	0	0	0.004672	0	0
C14orf106	55320	broad.mit.edu	37	14	45693947	45693947	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chr14:45693947delT	uc001wwf.2	-	11	2302	c.1843delA	c.(1843-1845)ACAfs	p.T615fs		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	615					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TCTTCAGTTGTCTCTTTAATT	0.294													25	19	---	---	---	---					
Unknown	0	broad.mit.edu	37	Y	13500860	13500860	+	IGR	DEL	G	-	-	rs76607402		TCGA-EM-A22O-01A-11D-A17V-08	TCGA-EM-A22O-10A-01D-A17V-08									Somatic	Phase_I	Capture				Illumina GAIIx	13642cf8-9840-4a7d-a26a-95f65b2c70c3	ea378b05-b95e-468d-b026-5a3b783795dc	g.chrY:13500860delG								None (None upstream) : None (None downstream)																							TGATTTCTAAGACTTTTGAAA	0.274													2	4	---	---	---	---					
