Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL17	339451	broad.mit.edu	37	1	899317	899317	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:899317C>T	uc001aca.1	+	9	1480	c.1373C>T	c.(1372-1374)CCC>CTC	p.P458L	KLHL17_uc001acc.1_RNA|PLEKHN1_uc001acd.2_5'Flank|PLEKHN1_uc001acf.2_5'Flank|PLEKHN1_uc001ace.2_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	458	Interaction with F-actin (By similarity).|Kelch 3.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CGCTACGACCCCCTGACCGGA	0.682000													41	46					0	0	0.000147903	0	0
WDR8	49856	broad.mit.edu	37	1	3551604	3551604	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:3551604A>G	uc001ako.2	-	8	881	c.773T>C	c.(772-774)ATC>ACC	p.I258T	WDR8_uc001akn.3_Missense_Mutation_p.I258T|WDR8_uc010nzi.1_3'UTR	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	258	WD 4.					centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AAACTCCGTGATCATTTTCCA	0.562000													32	95					0	0	0.000228196	0	0
KIAA0495	57212	broad.mit.edu	37	1	3662636	3662636	+	Silent	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:3662636C>G	uc009vlm.2	-	1	1251	c.132G>C	c.(130-132)ACG>ACC	p.T44T	KIAA0495_uc001akt.3_RNA	NM_207306	NP_997189			hypothetical protein LOC57212 precursor												0	all_cancers(77;0.0338)|Ovarian(185;0.0634)|Lung NSC(156;0.172)|all_lung(157;0.182)	all_epithelial(116;1.83e-21)|all_lung(118;2e-08)|Lung NSC(185;7.5e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;1.27e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.204)		GAGGAGGTACCGTGCCAATGC	0.642000													3	71					0	0	0.00024832	0	0
KLHDC7A	127707	broad.mit.edu	37	1	18809456	18809456	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:18809456C>T	uc001bax.2	+	1	2033	c.1981C>T	c.(1981-1983)CCC>TCC	p.P661S	KLHDC7A_uc009vpg.2_Missense_Mutation_p.P443S	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	661	Kelch 5.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGGCCGGCCCCACCGGGGG	0.682000													8	15					0	0	0.000157383	0	0
ARID1A	8289	broad.mit.edu	37	1	27089778	27089778	+	Splice_Site	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:27089778T>C	uc001bmv.1	+	8	3105	c.2732_splice	c.e8+2	p.R911_splice	ARID1A_uc001bmt.1_Splice_Site_p.R911_splice|ARID1A_uc001bmu.1_Splice_Site_p.R911_splice|ARID1A_uc001bmw.1_Splice_Site_p.R528_splice	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAAAACAGGTAAGGCCTGGG	0.512000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								6	13					0	0	3.59834e-05	0	0
STX12	23673	broad.mit.edu	37	1	28148824	28148824	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:28148824T>C	uc001bou.3	+	9	940	c.815T>C	c.(814-816)GTT>GCT	p.V272A		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	272	Vesicular (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTGGCTAGTTTATAAAACG	0.413000													30	89					0	0	0.000279167	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32503548	32503548	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:32503548A>G	uc001bub.2	+	6	1124	c.1018A>G	c.(1018-1020)AGG>GGG	p.R340G	KHDRBS1_uc001bua.1_Missense_Mutation_p.R301G|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	340	Pro-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCTACTGTGAGGGGTGCTCC	0.567000													3	65					0	0	6.4e-05	0	0
INPP5B	3633	broad.mit.edu	37	1	38406399	38406399	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:38406399T>C	uc001ccg.1	-	6	446	c.352A>G	c.(352-354)ACC>GCC	p.T118A	INPP5B_uc009vvk.1_Missense_Mutation_p.T59A|INPP5B_uc001cch.2_Missense_Mutation_p.T59A	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	118					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AACATCCTGGTTTGTGAACCA	0.577000													3	51					0	0	0.00024832	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45553649	45553649	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:45553649A>G	uc001cnd.2	-	2	1084	c.856T>C	c.(856-858)TAT>CAT	p.Y286H		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5	286							zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GTGATTAAATATTGAATAAAC	0.418000													7	84					0	0	8.12818e-05	0	0
DMRTA2	63950	broad.mit.edu	37	1	50884984	50884984	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:50884984G>A	uc010ona.1	-	2	1078	c.982C>T	c.(982-984)CGG>TGG	p.R328W	DMRTA2_uc010onb.1_Missense_Mutation_p.R328W	NM_032110	NP_115486	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	328	Gly-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						ACGCCTCGCCGGTGGCCTGGG	0.731000													10	26					0	0	6.40141e-05	0	0
TM2D1	83941	broad.mit.edu	37	1	62190765	62190765	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:62190765A>G	uc001czz.1	-	1	331	c.28T>C	c.(28-30)TCT>CCT	p.S10P		NM_032027	NP_114416	Q9BX74	TM2D1_HUMAN	beta-amyloid binding protein precursor	10					apoptosis					ovary(1)	1						TCCGGAGCAGACGGACCAGAC	0.682000													3	62					0	0	0.00024832	0	0
LEPR	3953	broad.mit.edu	37	1	66083654	66083654	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:66083654C>T	uc001dci.2	+	16	2422	c.2220C>T	c.(2218-2220)ATC>ATT	p.I740I	LEPR_uc001dcg.2_Silent_p.I740I|LEPR_uc001dch.2_Silent_p.I740I|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.I740I|LEPR_uc001dck.2_Silent_p.I740I	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	740	Extracellular (Potential).|Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CAGTAAATATCGTGCAGTCAC	0.303000													14	48					0	0	0.000219431	0	0
PHTF1	10745	broad.mit.edu	37	1	114253052	114253052	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:114253052A>G	uc009wgp.1	-	10	1545	c.1093T>C	c.(1093-1095)TCA>CCA	p.S365P	PHTF1_uc001edn.2_Missense_Mutation_p.S365P|PHTF1_uc001edm.2_Missense_Mutation_p.S122P|PHTF1_uc001edo.1_Missense_Mutation_p.S122P	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	365						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTCTTCTTGACATGTTGAGG	0.458000													12	41					0	0	0.000151284	0	0
SPAG17	200162	broad.mit.edu	37	1	118558773	118558773	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:118558773G>A	uc001ehk.2	-	29	4170	c.4102C>T	c.(4102-4104)CAT>TAT	p.H1368Y		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1368						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCACCCTTATGGGCCATTGAT	0.393000													28	62					0	0	0.000279167	0	0
FAM63A	55793	broad.mit.edu	37	1	150971957	150971957	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:150971957G>A	uc001ewf.2	-	8	2553	c.869C>T	c.(868-870)ACC>ATC	p.T290I	FAM63A_uc001ewc.2_Missense_Mutation_p.T148I|FAM63A_uc010pcm.1_Missense_Mutation_p.T195I|FAM63A_uc001ewd.2_Missense_Mutation_p.T148I|FAM63A_uc001ewe.2_Missense_Mutation_p.T124I|FAM63A_uc010pcn.1_Missense_Mutation_p.T338I|FAM63A_uc001ewg.2_Missense_Mutation_p.T290I	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	290							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGGGCCGCGGTGGTCTCCAG	0.547000													41	99					0	0	0.000680045	0	0
GABPB2	126626	broad.mit.edu	37	1	151079643	151079643	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:151079643C>T	uc001ewr.2	+	7	1198	c.867C>T	c.(865-867)ATC>ATT	p.I289I	GABPB2_uc001ews.2_Silent_p.I249I|GABPB2_uc001ewt.2_Silent_p.I150I	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	289					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		AAACTTCAATCCCTACTGGAG	0.438000													15	18					0	0	0.000308642	0	0
ILF2	3608	broad.mit.edu	37	1	153636568	153636568	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:153636568A>G	uc001fcr.2	-	10	776	c.695T>C	c.(694-696)ATT>ACT	p.I232T	ILF2_uc010pdy.1_Missense_Mutation_p.I194T|ILF2_uc009wok.2_Missense_Mutation_p.I210T	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	232	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGAAAACGAATCCTCAAGTC	0.393000													11	36					0	0	0.000151284	0	0
C1orf125	126859	broad.mit.edu	37	1	179503928	179503928	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:179503928T>C	uc001gmo.2	+	25	2989	c.2862T>C	c.(2860-2862)CAT>CAC	p.H954H	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Silent_p.H880H|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	954	Glu-rich.										0						AGAAACTTCATCATACCCTTA	0.299000													6	105					0	0	3.59834e-05	0	0
PRG4	10216	broad.mit.edu	37	1	186276943	186276943	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:186276943C>G	uc001gru.3	+	7	2143	c.2092C>G	c.(2092-2094)CCA>GCA	p.P698A	PRG4_uc001grt.3_Missense_Mutation_p.P657A|PRG4_uc009wyl.2_Missense_Mutation_p.P605A|PRG4_uc009wym.2_Missense_Mutation_p.P564A|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	698	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|41.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GGAGCCTGCTCCAACTACCCC	0.592000													10	33					0	0	0.00010058	0	0
NAV1	89796	broad.mit.edu	37	1	201763696	201763696	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:201763696A>G	uc001gwu.2	+	15	3855	c.3508A>G	c.(3508-3510)ACA>GCA	p.T1170A	NAV1_uc001gwv.1_Missense_Mutation_p.T695A|NAV1_uc001gww.1_Missense_Mutation_p.T771A|NAV1_uc001gwx.2_Missense_Mutation_p.T779A|NAV1_uc001gwy.1_Missense_Mutation_p.T543A	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1170					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CTCAGAAACCACACCCAAAGG	0.473000													10	30					0	0	6.40141e-05	0	0
CNTN2	6900	broad.mit.edu	37	1	205039135	205039135	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:205039135C>T	uc001hbr.2	+	18	2646	c.2377C>T	c.(2377-2379)CGC>TGC	p.R793C	CNTN2_uc001hbq.1_Missense_Mutation_p.R684C|CNTN2_uc001hbs.2_Missense_Mutation_p.R581C	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	793	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CAGCTACAACCGCCGCGGGGA	0.667000													14	12					0	0	0.000308642	0	0
TRAF5	7188	broad.mit.edu	37	1	211545679	211545679	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:211545679C>G	uc001hih.2	+	11	1369	c.1309C>G	c.(1309-1311)CGC>GGC	p.R437G	TRAF5_uc001hii.2_Missense_Mutation_p.R437G|TRAF5_uc010psx.1_Missense_Mutation_p.R448G|TRAF5_uc010psy.1_Missense_Mutation_p.R331G|TRAF5_uc001hij.2_Missense_Mutation_p.R437G	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	437	MATH.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		CTACACCAGCCGCTGTGGCTA	0.537000													4	88					0	0	0.000602214	0	0
DISP1	84976	broad.mit.edu	37	1	223178941	223178941	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:223178941C>G	uc001hnu.1	+	8	4349	c.4202C>G	c.(4201-4203)TCG>TGG	p.S1401W		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1401					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AGCACTGGATCGTTACTCAAA	0.453000													6	257					0	0	3.59834e-05	0	0
HEATR1	55127	broad.mit.edu	37	1	236716882	236716882	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:236716882T>C	uc001hyd.1	-	43	6361	c.6236A>G	c.(6235-6237)AAG>AGG	p.K2079R	HEATR1_uc009xgh.1_Missense_Mutation_p.K1241R	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	2079					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GTTCCTAACCTTAGGCGAGGA	0.498000													18	41					0	0	0.000295444	0	0
EXO1	9156	broad.mit.edu	37	1	242016700	242016700	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr1:242016700C>T	uc001hzh.2	+	6	862	c.322C>T	c.(322-324)CGT>TGT	p.R108C	EXO1_uc001hzi.2_Missense_Mutation_p.R108C|EXO1_uc001hzj.2_Missense_Mutation_p.R108C|EXO1_uc009xgq.2_Missense_Mutation_p.R108C	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	108					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GCAACTTCTTCGTGAGGGGAA	0.418000								Direct_reversal_of_damage|Editing_and_processing_nucleases					27	65					0	0	0.000184323	0	0
UPF2	26019	broad.mit.edu	37	10	11985096	11985096	+	Silent	SNP	G	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr10:11985096G>T	uc001ila.2	-	16	3720	c.3246C>A	c.(3244-3246)TCC>TCA	p.S1082S	UPF2_uc001ilb.2_Silent_p.S1082S|UPF2_uc001ilc.2_Silent_p.S1082S	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1082	Glu-rich.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				TTTCCTTATTGGAATCTGTAA	0.318000													14	469					0.000308642	0.00886601	0.000308642	1	0
ANK3	288	broad.mit.edu	37	10	61828879	61828880	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr10:61828879_61828880CC>AA	uc001jky.2	-	37	11951_11952	c.11759_11760GG>TT	c.(11758-11760)AGG>ATT	p.R3920I	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3920					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTATGTTATCCCTGTGTGTGTT	0.426000													9	190					0	0	6.4e-05	0	0
KIF20B	9585	broad.mit.edu	37	10	91477240	91477240	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr10:91477240T>C	uc001kgs.1	+	10	1184	c.1112T>C	c.(1111-1113)ATT>ACT	p.I371T	KIF20B_uc001kgr.1_Missense_Mutation_p.I371T	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	371	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TCTCGTGTAATTCGAGTCAGT	0.234000													8	21					0	0	0.000673444	0	0
LZTS2	84445	broad.mit.edu	37	10	102763582	102763582	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr10:102763582C>G	uc001ksj.2	+	3	796	c.727C>G	c.(727-729)CCA>GCA	p.P243A	LZTS2_uc010qpw.1_Missense_Mutation_p.P243A|LZTS2_uc001ksk.2_Missense_Mutation_p.P243A|LZTS2_uc001ksl.2_Missense_Mutation_p.P243A|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	243	Ser-rich.|Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CACCAGCTCCCCAGGCGGGCA	0.692000													3	45					0	0	6.4e-05	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16863173	16863173	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:16863173C>T	uc001mmo.2	-	9	808	c.793G>A	c.(793-795)GAC>AAC	p.D265N	PLEKHA7_uc010rcu.1_Missense_Mutation_p.D265N	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	265	PH.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TCCTGGGTGTCGGCACTGAAG	0.587000													30	20					0	0	0.000409698	0	0
OSBP	5007	broad.mit.edu	37	11	59344407	59344407	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:59344407G>A	uc001noc.1	-	13	2632	c.2152C>T	c.(2152-2154)CGA>TGA	p.R718*	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	718					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGGTCAGGTCGTAACCGGCTG	0.483000													10	171					0	0	0.00010058	0	0
RAB1B	81876	broad.mit.edu	37	11	66039915	66039915	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:66039915A>G	uc001ohf.2	+	4	358	c.263A>G	c.(262-264)TAT>TGT	p.Y88C	uc001ohg.1_RNA	NM_030981	NP_112243	Q9H0U4	RAB1B_HUMAN	RAB1B, member RAS oncogene family	88					protein transport|small GTPase mediated signal transduction	Golgi apparatus|membrane	GTP binding|protein binding				0						ATCGTGGTGTATGACGTCACT	0.552000													8	24					0	0	0.000157383	0	0
INTS4	92105	broad.mit.edu	37	11	77614645	77614645	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:77614645T>G	uc001oys.2	-	17	2066	c.2038A>C	c.(2038-2040)AAT>CAT	p.N680H	C11orf67_uc001oyp.2_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	680					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			GCAGCTACATTCCACAACTTT	0.453000													3	37					0	0	0.00024832	0	0
DDX10	1662	broad.mit.edu	37	11	108577504	108577505	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:108577504_108577505CC>AA	uc001pkm.2	+	10	1327_1328	c.1262_1263CC>AA	c.(1261-1263)CCC>CAA	p.P421Q	DDX10_uc001pkl.1_Missense_Mutation_p.P421Q	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	421	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		ATTTTGCTACCCTCAGAAAAAG	0.347000			T	NUP98	AML*								9	234					0	0	6.4e-05	0	0
ZBTB16	7704	broad.mit.edu	37	11	114121168	114121168	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:114121168A>G	uc001pop.2	+	7	2177	c.1913A>G	c.(1912-1914)TAC>TGC	p.Y638C	ZBTB16_uc001poq.2_Missense_Mutation_p.Y638C	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	638	C2H2-type 9.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TGCACAGAGTACTGCCCCAGC	0.612000													8	21					0	0	0.000274275	0	0
OR8B4	283162	broad.mit.edu	37	11	124293983	124293983	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:124293983G>A	uc010sak.1	-	1	785	c.785C>T	c.(784-786)TCT>TTT	p.S262F		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCCAGGAAAAGATGTTGTTAA	0.453000													16	15					0	0	0.000422831	0	0
DCP1B	196513	broad.mit.edu	37	12	2107114	2107114	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:2107114A>G	uc001qjx.1	-	2	258	c.178T>C	c.(178-180)TTT>CTT	p.F60L	DCP1B_uc010sdy.1_5'UTR|DCP1B_uc010sdz.1_Missense_Mutation_p.F60L	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	60					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GTATAAACAAATAAGGTTCCT	0.308000													22	119					0	0	0.000586117	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374864	8374864	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:8374864C>T	uc001qui.2	-	7	1508	c.949G>A	c.(949-951)GAA>AAA	p.E317K	FAM90A1_uc001quh.2_Missense_Mutation_p.E317K	NM_018088	NP_060558	Q86YD7	F90A1_HUMAN	hypothetical protein LOC55138	317							nucleic acid binding|zinc ion binding			ovary(1)	1				Kidney(36;0.0866)		ATGGCGCTTTCGGGGATCTGG	0.632000													12	12					0	0	0.000151284	0	0
OLR1	4973	broad.mit.edu	37	12	10313476	10313476	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:10313476A>G	uc001qxo.1	-	4	587	c.473T>C	c.(472-474)TTT>TCT	p.F158S	OLR1_uc010sgz.1_Intron|OLR1_uc010sha.1_Intron	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	158	Extracellular (Potential).|C-type lectin.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						GCCCGAGGAAAATAGGTAACA	0.428000													26	107					0	0	0.000184323	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18573894	18573894	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:18573894C>T	uc001rdt.2	+	16	2328	c.2212C>T	c.(2212-2214)CGT>TGT	p.R738C	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R779C|PIK3C2G_uc010sic.1_Missense_Mutation_p.R557C	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	738					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TCAAGAAATTCGTAAAGTGGC	0.363000													34	68					0	0	0.000692331	0	0
GYS2	2998	broad.mit.edu	37	12	21712632	21712632	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:21712632A>G	uc001rfb.2	-	9	1437	c.1182T>C	c.(1180-1182)CAT>CAC	p.H394H		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	394					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						CCTTCACAGAATGTGCAACAT	0.303000													12	56					0	0	0.000219431	0	0
DDX11	1663	broad.mit.edu	37	12	31237922	31237922	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:31237922G>C	uc001rjt.1	+	5	751	c.500G>C	c.(499-501)AGA>ACA	p.R167T	DDX11_uc010sjw.1_Missense_Mutation_p.R167T|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.R167T|DDX11_uc001rjs.1_Missense_Mutation_p.R167T|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R167T|DDX11_uc001rjw.1_Missense_Mutation_p.R141T|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	167	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GAAGAAGAAAGAGAGAATCTC	0.612000										Multiple Myeloma(12;0.14)			3	8					0	0	0.00024832	0	0
KCNH3	23416	broad.mit.edu	37	12	49938082	49938082	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:49938082T>C	uc001ruh.1	+	7	1366	c.1106T>C	c.(1105-1107)CTG>CCG	p.L369P	KCNH3_uc010smj.1_Missense_Mutation_p.L309P	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	369	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GTGTTCGCCCTGCTCGCGCAC	0.552000													3	18					0	0	6.4e-05	0	0
OBFC2B	79035	broad.mit.edu	37	12	56619456	56619456	+	Silent	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:56619456G>C	uc001ski.2	+	4	391	c.267G>C	c.(265-267)GGG>GGC	p.G89G	OBFC2B_uc001skk.2_Silent_p.G114G|OBFC2B_uc001skj.2_Silent_p.G105G	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	89	OB.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						CTGGCCGTGGGGGTGATCTGC	0.478000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					4	118					0	0	3.59834e-05	0	0
TRHDE	29953	broad.mit.edu	37	12	72863541	72863541	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:72863541T>C	uc001sxa.2	+	4	1214	c.1184T>C	c.(1183-1185)CTT>CCT	p.L395P		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	395	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTCTAGATCTTTTAGCTGTG	0.353000													16	88					0	0	9.7654e-05	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85441228	85441228	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:85441228A>G	uc001tac.2	+	6	769	c.658A>G	c.(658-660)AAA>GAA	p.K220E	LRRIQ1_uc001tab.1_Missense_Mutation_p.K220E|LRRIQ1_uc001taa.1_Missense_Mutation_p.K220E|LRRIQ1_uc001tad.2_Missense_Mutation_p.K128E	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	220	Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TGAAAAGAAGAAATTAGAGAA	0.313000													22	165					0	0	0.000720815	0	0
NEDD1	121441	broad.mit.edu	37	12	97306520	97306520	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:97306520A>G	uc001teu.3	+	4	495	c.156A>G	c.(154-156)GCA>GCG	p.A52A	NEDD1_uc001tev.3_Silent_p.A52A|NEDD1_uc010svc.1_Intron|NEDD1_uc001tew.2_Silent_p.A59A|NEDD1_uc001tex.2_5'UTR	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	52	WD 2.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TAGTAACAGCATCTTCCAGTG	0.328000													16	61					0	0	7.07596e-05	0	0
SLC5A8	160728	broad.mit.edu	37	12	101555752	101555752	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:101555752C>T	uc001thz.3	-	13	2020	c.1630G>A	c.(1630-1632)GGA>AGA	p.G544R		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	544	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AGATAGTTACCTGTTGATAAA	0.308000													119	141					0	0	0.000147903	0	0
STAB2	55576	broad.mit.edu	37	12	104107510	104107510	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:104107510A>G	uc001tjw.2	+	42	4687	c.4501A>G	c.(4501-4503)AAA>GAA	p.K1501E	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1501	Extracellular (Potential).|EGF-like 12.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTGCACGTGCAAAGCAGGCTA	0.502000													6	192					0	0	3.59834e-05	0	0
ACAD10	80724	broad.mit.edu	37	12	112182517	112182517	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:112182517T>C	uc001tsq.2	+	13	1985	c.1785T>C	c.(1783-1785)GAT>GAC	p.D595D	ACAD10_uc001tsp.2_Silent_p.D595D|ACAD10_uc009zvx.2_Silent_p.D626D|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	595							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TGGCGTGGGATTTCGCAGTCA	0.493000													4	132					0	0	0.00024832	0	0
HSPB8	26353	broad.mit.edu	37	12	119617327	119617327	+	Silent	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:119617327C>G	uc001txb.2	+	1	733	c.210C>G	c.(208-210)CCC>CCG	p.P70P	HSPB8_uc001txc.2_Silent_p.P70P	NM_014365	NP_055180	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	70					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCATGGTGCCCCGGGGCCCCA	0.682000													18	22					0	0	9.7654e-05	0	0
CABP1	9478	broad.mit.edu	37	12	121098957	121098957	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr12:121098957C>A	uc001tyu.2	+	5	1090	c.1023C>A	c.(1021-1023)CAC>CAA	p.H341Q	CABP1_uc001tyv.2_Missense_Mutation_p.H198Q|CABP1_uc001tyw.2_Missense_Mutation_p.H138Q|CABP1_uc001tyx.2_Missense_Mutation_p.H183Q	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	341	EF-hand 4.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGGTGGGACACCGAGACATAG	0.522000													89	333					6.72522e-28	2.00305e-26	0.000147903	1	0
CPB2	1361	broad.mit.edu	37	13	46627854	46627854	+	Silent	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr13:46627854C>G	uc001vaw.2	-	11	1234	c.1167G>C	c.(1165-1167)ACG>ACC	p.T389T	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Intron|ZC3H13_uc001vas.1_5'Flank|ZC3H13_uc001vat.1_5'Flank	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	389					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		CGTATGTGCCCGTATCTCGAA	0.438000													3	56					0	0	0.00024832	0	0
FAM155A	728215	broad.mit.edu	37	13	108518712	108518712	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr13:108518712T>C	uc001vql.2	-	1	749	c.233A>G	c.(232-234)CAG>CGG	p.Q78R		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	78	Poly-Gln.					integral to membrane	binding			skin(1)	1						ctgctgctgctgccgctgctg	0.358000													3	34					0	0	0.00024832	0	0
SOS2	6655	broad.mit.edu	37	14	50605367	50605367	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr14:50605367T>C	uc001wxs.3	-	18	3019	c.2921A>G	c.(2920-2922)AAT>AGT	p.N974S	SOS2_uc010tql.1_Missense_Mutation_p.N941S|SOS2_uc010tqm.1_RNA	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	974	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					GTAAGGCTGATTCTGATACTG	0.284000													11	41					0	0	0.000308642	0	0
ADAM6	8755	broad.mit.edu	37	14	106993798	106993798	+	Splice_Site	SNP	C	T	T	rs7146961	by1000genomes	TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr14:106993798C>T	uc010tyt.1	-	187		c.8648_splice	c.e187+1							Parts of antibodies, mostly variable regions.												0						TCACACTGACCTCCCCTCACT	0.587000													5	13					0	0	8.12818e-05	0	0
OR4N3P	390539	broad.mit.edu	37	15	22413739	22413739	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:22413739C>T	uc001yuf.2	+	1	38	c.38C>T	c.(37-39)TCC>TTC	p.S13F		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						AAGGTAATCTCCTACAGAGGC	0.488000													37	219					0	0	0.000191422	0	0
GABRB3	2562	broad.mit.edu	37	15	26793000	26793000	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:26793000G>A	uc001zaz.2	-	9	1504	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	GABRB3_uc010uae.1_Silent_p.I369I|GABRB3_uc001zba.2_Silent_p.I454I|GABRB3_uc001zbb.2_Silent_p.I510I	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	454	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGGAAACACGATCCTGGACC	0.398000													27	52					0	0	0.000227799	0	0
GANC	2595	broad.mit.edu	37	15	42579894	42579894	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:42579894T>C	uc001zpi.2	+	4	521	c.207T>C	c.(205-207)CCT>CCC	p.P69P	GANC_uc001zph.2_Silent_p.P69P|GANC_uc001zpj.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	69					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TCCAGGTTCCTCTCCTGGCTG	0.368000													3	33					0	0	0.00024832	0	0
MYEF2	50804	broad.mit.edu	37	15	48443760	48443761	+	Missense_Mutation	DNP	GG	TA	TA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:48443760_48443761GG>TA	uc001zwi.3	-	13	1339_1340	c.1215_1216CC>TA	c.(1213-1218)TACCGT>TATAGT	p.R406S	MYEF2_uc001zwg.3_5'Flank|MYEF2_uc001zwh.3_Missense_Mutation_p.R18S|MYEF2_uc001zwj.3_Missense_Mutation_p.R406S	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	406	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		ATCGCACCACGGTACAGCTCTG	0.381000													13	215					0	0	6.4e-05	0	0
LOC645752	645752	broad.mit.edu	37	15	78208197	78208197	+	Silent	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:78208197G>C	uc010bky.2	-	15	1736	c.972C>G	c.(970-972)GTC>GTG	p.V324V	LOC645752_uc010umq.1_5'Flank|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CAGAAGGCTGGACGAATCCAA	0.602000													3	35					0	0	6.4e-05	0	0
LUC7L	55692	broad.mit.edu	37	16	240074	240074	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:240074T>C	uc002cgc.1	-	9	978	c.867A>G	c.(865-867)AAA>AAG	p.K289K	LUC7L_uc002cga.1_Silent_p.K289K|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Silent_p.K289K|LUC7L_uc002cgb.1_Silent_p.K203K	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	289	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACCGGGACAATTTCCGTCGCT	0.642000													3	36					0	0	6.4e-05	0	0
IFT140	9742	broad.mit.edu	37	16	1612079	1612079	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:1612079C>G	uc002cmb.2	-	18	2468	c.2106G>C	c.(2104-2106)GAG>GAC	p.E702D	IFT140_uc002clz.2_Missense_Mutation_p.E353D	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	702										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GGAAGCCGTGCTCTTCGGAAA	0.453000													37	21					0	0	0.000191422	0	0
ADCY9	115	broad.mit.edu	37	16	4016397	4016397	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:4016397G>A	uc002cvx.2	-	11	3980	c.3441C>T	c.(3439-3441)CGC>CGT	p.R1147R		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	1147	Guanylate cyclase 2.|Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						CGTCCACCACGCGCATCATCT	0.632000													32	48					0	0	0.000339439	0	0
ZNF23	7571	broad.mit.edu	37	16	71483529	71483529	+	Silent	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:71483529G>C	uc002faf.2	-	6	1213	c.399C>G	c.(397-399)ACC>ACG	p.T133T	ZNF23_uc002fad.2_Silent_p.T75T|ZNF23_uc002fae.2_Silent_p.T75T|ZNF23_uc010vmf.1_Silent_p.T75T|ZNF23_uc002fag.2_Silent_p.T75T|ZNF23_uc002fah.2_Silent_p.T133T|ZNF23_uc002fai.2_Silent_p.T172T	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CTCCAGTGATGGTATGACACT	0.428000													4	74					0	0	0.00024832	0	0
CHST4	10164	broad.mit.edu	37	16	71571634	71571634	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:71571634G>A	uc002fan.2	+	2	1235	c.1054G>A	c.(1054-1056)GAT>AAT	p.D352N	CHST4_uc002fao.2_Missense_Mutation_p.D352N	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	352	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGCCTGTGGCGATGCCATGAA	0.512000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	9					0	0	0.00047179	0	0
MON1B	22879	broad.mit.edu	37	16	77232194	77232194	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr16:77232194A>G	uc002fez.2	+	6	1963	c.1633A>G	c.(1633-1635)ACT>GCT	p.T545A	MON1B_uc010vnf.1_Missense_Mutation_p.T436A|MON1B_uc010vng.1_Missense_Mutation_p.T399A|MON1B_uc002ffa.2_Missense_Mutation_p.T425A|SYCE1L_uc010vnh.1_5'Flank	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	545							protein binding				0						TGGCTTGTTCACTGGACTCTG	0.537000													14	30					0	0	0.000151284	0	0
KDM6B	23135	broad.mit.edu	37	17	7752375	7752375	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:7752375C>T	uc002giw.1	+	11	3145	c.2769C>T	c.(2767-2769)ACC>ACT	p.T923T	KDM6B_uc002gix.2_Silent_p.T225T	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	923					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CTTGCGAGACCCTTGTGGAGC	0.687000													10	25					0	0	0.00010058	0	0
DNAH9	1770	broad.mit.edu	37	17	11583132	11583132	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:11583132G>A	uc002gne.2	+	18	3480	c.3412G>A	c.(3412-3414)GAA>AAA	p.E1138K	DNAH9_uc010coo.2_Missense_Mutation_p.E432K	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1138	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAAGAAAGTTGAAAAAGGAGA	0.428000													44	120					0	0	0.000147903	0	0
DNAH9	1770	broad.mit.edu	37	17	11648356	11648356	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:11648356G>A	uc002gne.2	+	31	6422	c.6354G>A	c.(6352-6354)GCG>GCA	p.A2118A	DNAH9_uc010coo.2_Silent_p.A1412A	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2118	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAGGAAGGCGATAGTGGATC	0.517000													22	58					0	0	0.000117367	0	0
TEKT3	64518	broad.mit.edu	37	17	15215662	15215662	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:15215662G>T	uc002gon.2	-	7	1202	c.1015C>A	c.(1015-1017)CAA>AAA	p.Q339K		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	339					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TTGTTGAATTGATTCCACATC	0.448000													24	76					3.96558e-24	1.17493e-22	0.000720815	1	0
PRPSAP2	5636	broad.mit.edu	37	17	18785968	18785969	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:18785968_18785969CC>AA	uc002gup.1	+	7	711_712	c.500_501CC>AA	c.(499-501)CCC>CAA	p.P167Q	PRPSAP2_uc002guo.1_Missense_Mutation_p.P81Q|PRPSAP2_uc010vyi.1_Missense_Mutation_p.P115Q|PRPSAP2_uc010vyj.1_Missense_Mutation_p.P81Q|PRPSAP2_uc010vyk.1_Missense_Mutation_p.P155Q	NM_002767	NP_002758	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate	167					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			skin(1)	1						AGAGCATCTCCCTTCTTATTAC	0.317000													13	286					0	0	6.4e-05	0	0
RAB34	83871	broad.mit.edu	37	17	27042505	27042505	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:27042505G>A	uc002hce.2	-	6	1024	c.400C>T	c.(400-402)CTG>TTG	p.L134L	RAB34_uc002hcg.2_Silent_p.L134L|RAB34_uc002hcf.2_Silent_p.L135L|RAB34_uc010was.1_Silent_p.L191L|RAB34_uc010wat.1_Silent_p.L191L|RAB34_uc002hch.2_Silent_p.L134L|RAB34_uc010wau.1_Silent_p.L112L|RAB34_uc010wav.1_Silent_p.L192L	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	134					protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					ACATCATTCAGGTTGAAGACA	0.502000													10	45					0	0	6.40141e-05	0	0
TBC1D29	26083	broad.mit.edu	37	17	28890334	28890334	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:28890334G>A	uc002hfh.2	+	5	493	c.344G>A	c.(343-345)AGG>AAG	p.R115K	TBC1D29_uc002hfi.2_RNA	NM_015594	NP_056409	Q9UFV1	TBC29_HUMAN	TBC1 domain family, member 29	115						intracellular	Rab GTPase activator activity				0		Myeloproliferative disorder(56;0.0255)				ACTCCTCCAAGGGTGCCAGGA	0.498000													6	23					0	0	3.59834e-05	0	0
SLFN5	162394	broad.mit.edu	37	17	33592480	33592480	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:33592480G>T	uc002hjf.3	+	5	2366	c.2249G>T	c.(2248-2250)TGG>TTG	p.W750L	SLFN5_uc010wcg.1_3'UTR	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	750					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GAACCTAAATGGGCTCAAGGT	0.458000													8	81					1.58986e-06	4.63765e-05	0.000673444	1	0
KRT13	3860	broad.mit.edu	37	17	39659636	39659636	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:39659636C>G	uc002hwu.1	-	3	701	c.638G>C	c.(637-639)CGG>CCG	p.R213P	KRT13_uc002hwv.1_Missense_Mutation_p.R213P|KRT13_uc002hww.2_Missense_Mutation_p.R106P|KRT13_uc010wfr.1_Missense_Mutation_p.R106P|KRT13_uc010cxo.2_Missense_Mutation_p.R213P|KRT13_uc002hwx.1_Missense_Mutation_p.R201P	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	213	Coil 1B.|Rod.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				ATCCAGCACCCGGCGCAGGCC	0.488000													3	65					0	0	0.00024832	0	0
ERN1	2081	broad.mit.edu	37	17	62149454	62149454	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:62149454T>C	uc002jdz.2	-	6	478	c.365A>G	c.(364-366)CAG>CGG	p.Q122R		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	122	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						CCAGATGTCCTGCTTTTTACC	0.448000													6	22					0	0	0.000157383	0	0
ABCA6	23460	broad.mit.edu	37	17	67107019	67107019	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:67107019G>C	uc002jhw.1	-	17	2370	c.2195C>G	c.(2194-2196)CCC>CGC	p.P732R	ABCA6_uc002jhx.1_Missense_Mutation_p.P185R	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	732					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TTTAGCATCGGGGATGTGATG	0.303000													3	42					0	0	0.00024832	0	0
FAM104A	84923	broad.mit.edu	37	17	71228388	71228388	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:71228388A>T	uc002jji.3	-	1	146	c.58T>A	c.(58-60)TAC>AAC	p.Y20N	FAM104A_uc002jjj.3_Missense_Mutation_p.Y20N|C17orf80_uc010wqu.1_5'UTR|C17orf80_uc010dfj.2_5'UTR|C17orf80_uc002jjk.1_5'Flank|C17orf80_uc002jjm.3_5'Flank|C17orf80_uc002jjl.3_5'Flank	NM_032837	NP_116226	Q969W3	F104A_HUMAN	hypothetical protein LOC84923 isoform 2	20											0			LUSC - Lung squamous cell carcinoma(166;0.197)			GGTGGCGAGTACCCCTCAGTC	0.721000													9	24					0	0	6.40141e-05	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74307767	74307767	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:74307767A>G	uc010wta.1	-	10	1460	c.1014T>C	c.(1012-1014)AAT>AAC	p.N338N	PRPSAP1_uc010wtb.1_Silent_p.N235N	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	309					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						GAGGGACAGTATTCGTCACCA	0.433000													10	30					0	0	0.000308642	0	0
LAMA1	284217	broad.mit.edu	37	18	7049160	7049160	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr18:7049160G>A	uc002knm.2	-	5	779	c.685C>T	c.(685-687)CAA>TAA	p.Q229*	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	229	Laminin N-terminal.			LQ -> FE (in Ref. 3; CAA41418).	axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTAATGCGTTGCAAGCGAAGG	0.478000													26	50					0	0	0.000339439	0	0
ANKRD12	23253	broad.mit.edu	37	18	9195588	9195588	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr18:9195588A>G	uc002knv.2	+	3	384	c.127A>G	c.(127-129)ATT>GTT	p.I43V	ANKRD12_uc010wzn.1_Missense_Mutation_p.I43V|ANKRD12_uc002knw.2_Missense_Mutation_p.I43V|ANKRD12_uc002knx.2_Missense_Mutation_p.I43V	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	43						nucleus				ovary(2)|central_nervous_system(1)	3						AACTCCAAAAATTGAACGAAG	0.323000													9	12					0	0	0.000274275	0	0
SERPINB7	8710	broad.mit.edu	37	18	61471868	61471868	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr18:61471868G>A	uc002ljl.2	+	8	1238	c.1142G>A	c.(1141-1143)TGA>TAA	p.*381*	SERPINB7_uc002ljm.2_Silent_p.*381*|SERPINB7_uc010xet.1_Silent_p.*364*|SERPINB7_uc010dqg.2_Silent_p.*381*	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	381					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TCTTGCCCTTGAAAATCCAAT	0.403000													34	6					0	0	0.000159656	0	0
RTTN	25914	broad.mit.edu	37	18	67742646	67742646	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr18:67742646A>G	uc002lkp.2	-	33	4574	c.4506T>C	c.(4504-4506)TGT>TGC	p.C1502C	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.C590C	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1502							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AATCAAACATACACCGTCCTA	0.308000													26	69					0	0	0.000279167	0	0
LPPR2	64748	broad.mit.edu	37	19	11472104	11472104	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:11472104G>A	uc002mre.1	+	6	940	c.603G>A	c.(601-603)GCG>GCA	p.A201A	LPPR2_uc002mrf.1_Silent_p.A176A|LPPR2_uc010dxy.1_5'UTR	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	201						integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TGGCCGCCGCGCGCCGCGCCT	0.701000													14	25					0	0	0.000151284	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:21606712T>C	uc002npx.2	+	2	1147	c.867T>C	c.(865-867)TCT>TCC	p.S289S	ZNF493_uc002npw.2_Silent_p.S417S|ZNF493_uc002npy.2_Silent_p.S289S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	289	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAAGGAGTCTTCACACCTTA	0.348000													3	34					0	0	6.4e-05	0	0
THAP8	199745	broad.mit.edu	37	19	36530862	36530862	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:36530862C>T	uc002oda.1	-	2	805	c.260G>A	c.(259-261)CGG>CAG	p.R87Q	uc002ocy.2_Intron|THAP8_uc010xtb.1_Missense_Mutation_p.R44Q|THAP8_uc010xtc.1_Intron	NM_152658	NP_689871	Q8NA92	THAP8_HUMAN	THAP domain containing 8	87							DNA binding|metal ion binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGGTGGTCCCCGGGAGAAGAT	0.627000													7	23					0	0	0.000442599	0	0
MAP4K1	11184	broad.mit.edu	37	19	39078451	39078451	+	Nonstop_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:39078451T>C	uc002oix.1	-	32	2609	c.2501A>G	c.(2500-2502)TAG>TGG	p.*834W	MAP4K1_uc002oiw.1_Silent_p.V388V|MAP4K1_uc002oiy.1_Silent_p.V801V	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	834					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCTCCACCACTACAGGCCTGT	0.393000													13	31					0	0	7.07596e-05	0	0
PSG6	5675	broad.mit.edu	37	19	43411754	43411754	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:43411754C>T	uc002ovj.1	-	4	1011	c.959G>A	c.(958-960)AGT>AAT	p.S320N	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.S327N|PSG6_uc002ovi.2_Missense_Mutation_p.S321N|PSG6_uc010xwk.1_Missense_Mutation_p.S160N|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Missense_Mutation_p.S110N|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Missense_Mutation_p.S320N	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	320	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GACTGGGTTACTGCGGATGCC	0.507000													18	48					0	0	7.07596e-05	0	0
PSG6	5675	broad.mit.edu	37	19	43420344	43420344	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:43420344G>A	uc002ovj.1	-	2	412	c.360C>T	c.(358-360)ACC>ACT	p.T120T	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ovf.1_Silent_p.T120T|PSG6_uc002ovg.1_Silent_p.T120T	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	120	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TGATGTGTAAGGTGTAGGATC	0.473000													38	120					0	0	0.000270559	0	0
ZFP112	7771	broad.mit.edu	37	19	44832140	44832140	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:44832140A>T	uc010ejj.2	-	5	2301	c.2188T>A	c.(2188-2190)TTC>ATC	p.F730I	ZFP112_uc002ozc.3_Missense_Mutation_p.F724I|ZFP112_uc010xwy.1_Missense_Mutation_p.F747I|ZFP112_uc010xwz.1_Missense_Mutation_p.F729I	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	730	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTCTGACTGAAGCCCTTTCCA	0.443000													31	95					0	0	0.000692331	0	0
TULP2	7288	broad.mit.edu	37	19	49391383	49391383	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr19:49391383A>G	uc002pkz.2	-	8	923	c.772T>C	c.(772-774)TCC>CCC	p.S258P		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	258					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ATTGCCAAGGAGGCTTCGTGC	0.627000													5	23					0	0	0.000602214	0	0
TTC15	51112	broad.mit.edu	37	2	3482633	3482633	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:3482633G>C	uc002qxm.1	+	11	2100	c.1894G>C	c.(1894-1896)GGG>CGG	p.G632R	TTC15_uc002qxn.1_Missense_Mutation_p.G632R|TTC15_uc010ewm.1_Missense_Mutation_p.G638R	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	632	TPR 3.						binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CCTTCACCTCGGGCAGAATAA	0.547000													3	76					0	0	3.59834e-05	0	0
ROCK2	9475	broad.mit.edu	37	2	11332358	11332359	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:11332358_11332359CG>AT	uc002rbd.1	-	32	4527_4528	c.4078_4079CG>AT	c.(4078-4080)CGA>ATA	p.R1360I		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	1360					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AGGAGATGATCGGGCAAAAGGG	0.431000													7	203					0	0	6.4e-05	0	0
GREB1	9687	broad.mit.edu	37	2	11761042	11761042	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:11761042A>G	uc002rbk.1	+	23	4356	c.4056A>G	c.(4054-4056)ACA>ACG	p.T1352T	GREB1_uc002rbp.1_Silent_p.T350T	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1352						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCGGGAAGACAGGTGCCTACC	0.532000													26	115					0	0	0.000720815	0	0
TMEM214	54867	broad.mit.edu	37	2	27263000	27263000	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:27263000C>T	uc002ria.3	+	15	1835	c.1725C>T	c.(1723-1725)TTC>TTT	p.F575F	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Silent_p.F530F	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	575						integral to membrane	protein binding				0						CAGTCAGCTTCCTTTCTGCCC	0.612000													27	32					0	0	0.000147802	0	0
BIRC6	57448	broad.mit.edu	37	2	32710826	32710826	+	Silent	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:32710826T>C	uc010ezu.2	+	40	7947	c.7813T>C	c.(7813-7815)TTA>CTA	p.L2605L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2605					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATCTCCTACATGTAAGTAAAA	0.358000													4	62					0	0	0.000602214	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809275	48809275	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:48809275C>T	uc010yol.1	+	1	1550	c.1503C>T	c.(1501-1503)ATC>ATT	p.I501I	STON1_uc002rwo.3_Silent_p.I501I|STON1_uc010fbm.2_Silent_p.I501I|STON1-GTF2A1L_uc002rwp.1_Silent_p.I501I|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Silent_p.I501I	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	501					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AATCAAGAATCATTAAGTTTG	0.378000													52	70					0	0	0.000147903	0	0
MCEE	84693	broad.mit.edu	37	2	71351586	71351586	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:71351586C>T	uc002shs.2	-	2	173	c.128G>A	c.(127-129)TGG>TAG	p.W43*		NM_032601	NP_115990	Q96PE7	MCEE_HUMAN	methylmalonyl CoA epimerase precursor	43					fatty acid beta-oxidation|L-methylmalonyl-CoA metabolic process	mitochondrial matrix	methylmalonyl-CoA epimerase activity			ovary(1)	1						ACCCAGGTTCCACACAGAACC	0.468000													39	153					0	0	0.000589545	0	0
LIPT1	51601	broad.mit.edu	37	2	99779004	99779004	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:99779004G>A	uc002szm.3	+	4	924	c.584G>A	c.(583-585)AGC>AAC	p.S195N	MRPL30_uc002szl.1_Intron|LIPT1_uc002szn.3_Missense_Mutation_p.S195N|LIPT1_uc002szo.3_Missense_Mutation_p.S195N|LIPT1_uc002szp.3_Missense_Mutation_p.S195N|LIPT1_uc002szq.3_Missense_Mutation_p.S195N|MRPL30_uc002szr.2_Intron	NM_145198	NP_660199	Q9Y234	LIPT_HUMAN	lipoyltransferase 1 precursor	195					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity				0					Lipoic Acid(DB00166)	TTGCTAAAGAGCCCTTACCAA	0.443000													15	55					0	0	0.000308642	0	0
RANBP2	5903	broad.mit.edu	37	2	109352212	109352213	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:109352212_109352213CC>AA	uc002tem.3	+	5	756_757	c.630_631CC>AA	c.(628-633)ACCCTT>ACAATT	p.L211I		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	211					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTGTACAGACCCTTAAGGTAGA	0.411000													10	291					0	0	6.4e-05	0	0
RGPD5	84220	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:113127775G>C	uc002ths.1	-	23	5355	c.5278C>G	c.(5278-5280)CCT>GCT	p.P1760A	RGPD8_uc010fkk.1_Missense_Mutation_p.P1620A	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	1760					intracellular transport	cytoplasm	binding				0						GAACGGGAAGGATTTTCTTCC	0.308000													5	117					0	0	0.000602214	0	0
DPP10	57628	broad.mit.edu	37	2	116497425	116497425	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:116497425A>G	uc002tla.1	+	9	1265	c.808A>G	c.(808-810)ACT>GCT	p.T270A	DPP10_uc002tlb.1_Missense_Mutation_p.T220A|DPP10_uc002tlc.1_Missense_Mutation_p.T266A|DPP10_uc002tle.2_Missense_Mutation_p.T274A|DPP10_uc002tlf.1_Missense_Mutation_p.T263A	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	270	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CCCTCGGTTTACTGGAGCGTT	0.458000													4	125					0	0	3.59834e-05	0	0
TANC1	85461	broad.mit.edu	37	2	160042337	160042337	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:160042337G>A	uc002uag.2	+	15	2820	c.2546G>A	c.(2545-2547)CGT>CAT	p.R849H	TANC1_uc010zcm.1_Missense_Mutation_p.R841H|TANC1_uc010fom.1_Missense_Mutation_p.R655H	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	849						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						ATGTTCTCGCGTCAGGAGGGC	0.572000											OREG0015033	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	29					0	0	0.000375601	0	0
SLC4A10	57282	broad.mit.edu	37	2	162751283	162751283	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:162751283G>A	uc002ubx.3	+	11	1473	c.1289G>A	c.(1288-1290)GGA>GAA	p.G430E	SLC4A10_uc010fpa.1_Missense_Mutation_p.G442E|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.G400E|SLC4A10_uc010zcs.1_Missense_Mutation_p.G411E	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	430	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTCCCTCCTGGAGAATGGGAT	0.368000													56	74					0	0	0.000147903	0	0
LRP2	4036	broad.mit.edu	37	2	170163817	170163817	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:170163817G>C	uc002ues.2	-	4	614	c.401C>G	c.(400-402)CCC>CGC	p.P134R	LRP2_uc010zdf.1_Missense_Mutation_p.P134R	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	134	Extracellular (Potential).|LDL-receptor class A 3.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGCTCCATCGGGGCAGTCTCT	0.458000													4	111					0	0	0.00024832	0	0
DLX1	1745	broad.mit.edu	37	2	172950461	172950461	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:172950461T>C	uc002uhl.2	+	1	254	c.56T>C	c.(55-57)GTG>GCG	p.V19A	DLX1_uc010fqj.1_Missense_Mutation_p.V19A|DLX1_uc002uhm.2_Missense_Mutation_p.V19A	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	19						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GGCAAGGCGGTGTTTATGGAG	0.582000													10	50					0	0	0.000673444	0	0
PMS1	5378	broad.mit.edu	37	2	190719501	190719501	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:190719501A>G	uc002urh.3	+	9	2032	c.1503A>G	c.(1501-1503)GGA>GGG	p.G501G	PMS1_uc010zga.1_Silent_p.G462G|PMS1_uc010zgb.1_Silent_p.G440G|PMS1_uc002urk.3_Silent_p.G462G|PMS1_uc002uri.3_Silent_p.G501G|PMS1_uc010zgc.1_Silent_p.G325G|PMS1_uc010zgd.1_Silent_p.G325G|PMS1_uc002urj.2_RNA|PMS1_uc010fry.1_Silent_p.G462G|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Silent_p.G286G|PMS1_uc002urm.2_RNA|PMS1_uc002urn.1_Silent_p.G169G	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	501					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			GGAGCAGGGGAAATATACTTA	0.343000			Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					13	54					0	0	0.00010058	0	0
USP37	57695	broad.mit.edu	37	2	219360645	219360645	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:219360645A>G	uc002vie.2	-	14	1763	c.1310T>C	c.(1309-1311)TTG>TCG	p.L437S	USP37_uc010fvs.1_Missense_Mutation_p.L437S|USP37_uc010zkf.1_Missense_Mutation_p.L437S|USP37_uc002vif.2_Missense_Mutation_p.L437S|USP37_uc002vig.2_Missense_Mutation_p.L365S	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	437					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		CAGCTGGTCCAAACACTGACT	0.313000													13	101					0	0	0.00010058	0	0
COL4A4	1286	broad.mit.edu	37	2	227915858	227915858	+	Silent	SNP	G	T	T	rs79261248	by1000genomes	TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:227915858G>T	uc010zlt.1	-	33	3639	c.2985C>A	c.(2983-2985)CCC>CCA	p.P995P		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	995	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTTGCATCCCGGGAGTTCCTT	0.517000													8	77					3.07112e-06	8.91254e-05	6.40141e-05	1	0
DNER	92737	broad.mit.edu	37	2	230456470	230456470	+	Silent	SNP	G	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr2:230456470G>T	uc002vpv.2	-	2	558	c.411C>A	c.(409-411)CCC>CCA	p.P137P		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	137	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CTGGGAGACTGGGAAGTGCCT	0.488000													22	23					1.2476e-16	3.67717e-15	0.000147802	1	0
SEC23B	10483	broad.mit.edu	37	20	18526600	18526600	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr20:18526600T>G	uc002wqz.1	+	15	2109	c.1666T>G	c.(1666-1668)TGT>GGT	p.C556G	SEC23B_uc002wra.1_Missense_Mutation_p.C556G|SEC23B_uc002wrb.1_Missense_Mutation_p.C556G|SEC23B_uc010zsb.1_Missense_Mutation_p.C538G|SEC23B_uc002wrc.1_Missense_Mutation_p.C556G	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	556					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						CTTTCCATAGTGTCAAAAGTT	0.323000													49	97					0	0	0.000147903	0	0
NKX2-2	4821	broad.mit.edu	37	20	21494091	21494091	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr20:21494091A>G	uc002wsi.2	-	1	574	c.217T>C	c.(217-219)TAC>CAC	p.Y73H		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	73					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						CAGCGCGTGTACGGGTTGTCG	0.682000													8	36					0	0	0.000673444	0	0
RPL3	6122	broad.mit.edu	37	22	39712780	39712780	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:39712780C>T	uc003axi.2	-	4	500	c.432G>A	c.(430-432)AAG>AAA	p.K144K	RPL3_uc003axh.2_Intron|RPL3_uc003axj.2_5'UTR|RPL3_uc010gxx.2_Silent_p.K92K|RPL3_uc003axg.2_Silent_p.K92K|RPL3_uc003axk.1_5'UTR	NM_000967	NP_000958	P39023	RL3_HUMAN	ribosomal protein L3 isoform a	144					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			breast(1)|kidney(1)	2	Melanoma(58;0.04)					TCTCCAGCTGCTTCTTGCCAT	0.547000											OREG0026575	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	106					0	0	0.000219431	0	0
POLR3H	171568	broad.mit.edu	37	22	41928710	41928710	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:41928710T>C	uc003baf.2	-	4	308	c.248A>G	c.(247-249)GAG>GGG	p.E83G	POLR3H_uc003bae.2_RNA|POLR3H_uc003bag.2_Missense_Mutation_p.E83G|POLR3H_uc003bai.2_Intron	NM_138338	NP_612211	Q9Y535	RPC8_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	83					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			skin(1)	1						AATGAGAATCTCATCTAGGAA	0.557000											OREG0026590	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	128					0	0	0.000117367	0	0
TCF20	6942	broad.mit.edu	37	22	42606930	42606930	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:42606930G>C	uc003bcj.1	-	1	4516	c.4382C>G	c.(4381-4383)CCT>CGT	p.P1461R	TCF20_uc003bck.1_Missense_Mutation_p.P1461R|TCF20_uc003bnt.2_Missense_Mutation_p.P1461R	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						CATGGCACCAGGGGGTTCCTT	0.512000													5	228					0	0	8.12818e-05	0	0
PARVB	29780	broad.mit.edu	37	22	44528816	44528816	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:44528816T>C	uc003ben.2	+	6	612	c.560T>C	c.(559-561)GTC>GCC	p.V187A	PARVB_uc003bem.2_Missense_Mutation_p.V220A|PARVB_uc010gzn.2_Missense_Mutation_p.V135A|PARVB_uc003beo.2_Missense_Mutation_p.V150A	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	187	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				CACCTGCTGGTCTCTCTGGCC	0.597000													6	78					0	0	0.000157383	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50661002	50661002	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:50661002A>G	uc003bkb.1	-	14	2802	c.2290T>C	c.(2290-2292)TAC>CAC	p.Y764H	TUBGCP6_uc003bka.1_5'Flank|TUBGCP6_uc010har.1_Intron|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'UTR	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	764					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGCTTGCTGTAGTGGTCGACC	0.597000													5	54					0	0	8.12818e-05	0	0
CPT1B	1375	broad.mit.edu	37	22	51009877	51009877	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:51009877T>C	uc003bmk.3	-	13	1829	c.1667A>G	c.(1666-1668)AAA>AGA	p.K556R	CPT1B_uc003bml.2_Missense_Mutation_p.K556R|CPT1B_uc003bmm.2_Missense_Mutation_p.K556R|CPT1B_uc003bmo.2_Missense_Mutation_p.K556R|CPT1B_uc011asa.1_Missense_Mutation_p.K522R|CPT1B_uc003bmn.2_Missense_Mutation_p.K556R|CPT1B_uc011asb.1_Missense_Mutation_p.K475R|CHKB-CPT1B_uc003bmp.2_Missense_Mutation_p.K351R|uc003bmr.1_RNA	NM_001145137	NP_001138609	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B isoform a	556	Coenzyme A binding (By similarity).|Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		GATGAGGCCTTTGCCAAAGGG	0.617000													7	158					0	0	0.000157383	0	0
LRRN1	57633	broad.mit.edu	37	3	3888346	3888346	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:3888346C>T	uc003bpt.3	+	2	2782	c.2021C>T	c.(2020-2022)TCA>TTA	p.S674L	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	674	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AAAACCTCTTCAATCCCACTA	0.438000													16	20					0	0	0.000132079	0	0
ZNF385D	79750	broad.mit.edu	37	3	21606177	21606177	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:21606177C>T	uc003cce.2	-	3	574	c.166_splice	c.e3-1	p.M56_splice	ZNF385D_uc010hfb.1_Splice_Site	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D							nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						TCGGGTCCATCTGTAATGAGA	0.363000													10	41					0	0	0.000673444	0	0
TRANK1	9881	broad.mit.edu	37	3	36888812	36888812	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:36888812G>A	uc003cgj.2	-	6	3433	c.3131C>T	c.(3130-3132)TCC>TTC	p.S1044F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1594					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TGTGAATGAGGAAATGATCTT	0.458000													8	23					0	0	0.000157383	0	0
CCRL2	9034	broad.mit.edu	37	3	46449815	46449815	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:46449815T>C	uc003cpp.3	+	2	530	c.245T>C	c.(244-246)GTT>GCT	p.V82A	CCRL2_uc010hjg.2_Missense_Mutation_p.V94A|CCRL2_uc010hjf.2_Missense_Mutation_p.V82A	NM_003965	NP_003956	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2 isoform 1	82	Helical; Name=2; (Potential).				chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		AACTTGGCAGTTTCTAACTTG	0.453000													21	46					0	0	0.00047179	0	0
PRSS50	29122	broad.mit.edu	37	3	46753939	46753939	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:46753939C>T	uc003cqe.1	-	6	1014	c.955G>A	c.(955-957)GAG>AAG	p.E319K	PRSS50_uc003cqf.1_Missense_Mutation_p.E233K	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	319	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						CACGTGCCCTCCATGGAGCAG	0.627000													4	15					0	0	0.000602214	0	0
PRSS45	377047	broad.mit.edu	37	3	46784546	46784546	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:46784546G>C	uc010hjl.2	-	3	310	c.310C>G	c.(310-312)CCA>GCA	p.P104A	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	136	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0						TGCAGCTCTGGGGTCAGCATG	0.587000													3	35					0	0	0.00024832	0	0
KIAA1524	57650	broad.mit.edu	37	3	108278845	108278845	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:108278845A>G	uc003dxb.3	-	15	2127	c.1858T>C	c.(1858-1860)TCT>CCT	p.S620P		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	620						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						ATTATGTCAGATATTCTCACA	0.249000													6	112					0	0	8.12818e-05	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603065	111603065	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:111603065G>A	uc010hqa.2	+	2	552	c.141G>A	c.(139-141)CTG>CTA	p.L47L	PHLDB2_uc003dyc.2_Silent_p.L74L|PHLDB2_uc003dyd.2_Silent_p.L47L|PHLDB2_uc003dyg.2_Silent_p.L47L|PHLDB2_uc003dyh.2_Silent_p.L47L|PHLDB2_uc003dye.3_Silent_p.L47L|PHLDB2_uc003dyf.3_Silent_p.L47L	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	47						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						CTTCCAGTCTGAGATTTAAAG	0.453000													42	86					0	0	0.000437636	0	0
PLCH1	23007	broad.mit.edu	37	3	155232561	155232561	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:155232561C>G	uc011bok.1	-	11	1824	c.1547G>C	c.(1546-1548)CGG>CCG	p.R516P	PLCH1_uc011boj.1_Missense_Mutation_p.R516P|PLCH1_uc011bol.1_Missense_Mutation_p.R498P	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	516					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAGTAGTGCCCGCACTGTGAA	0.408000													3	44					0	0	0.00024832	0	0
CCNL1	57018	broad.mit.edu	37	3	156866121	156866121	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:156866121T>C	uc003fbf.2	-	11	2089	c.1490A>G	c.(1489-1491)GAC>GGC	p.D497G	CCNL1_uc003fbd.1_Intron|CCNL1_uc003fbe.2_Missense_Mutation_p.D291G|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	497					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			TTCACGCCTGTCCCTATGATG	0.512000													5	100					0	0	0.000602214	0	0
ECE2	9718	broad.mit.edu	37	3	184001600	184001600	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr3:184001600G>A	uc003fni.3	+	8	1236	c.1198G>A	c.(1198-1200)GAG>AAG	p.E400K	ECE2_uc011brh.1_Missense_Mutation_p.E253K|ECE2_uc003fnl.3_Missense_Mutation_p.E328K|ECE2_uc003fnm.3_Missense_Mutation_p.E282K|ECE2_uc003fnk.3_Missense_Mutation_p.E253K|ECE2_uc011bri.1_Missense_Mutation_p.E315K|ECE2_uc010hxv.2_Missense_Mutation_p.E44K	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	400	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGATTACATGGAGGAACTGGG	0.592000													8	3					0	0	0.000274275	0	0
PCDH7	5099	broad.mit.edu	37	4	30725854	30725854	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:30725854A>G	uc003gsk.1	+	1	3818	c.2810A>G	c.(2809-2811)GAC>GGC	p.D937G	PCDH7_uc011bxw.1_Missense_Mutation_p.D890G|PCDH7_uc011bxx.1_Missense_Mutation_p.D937G	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	937	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CCTAAAAAGGACAAGAAAAAC	0.398000													25	60					0	0	0.000720815	0	0
C4orf7	260436	broad.mit.edu	37	4	71099788	71099788	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:71099788T>C	uc003hfd.2	+	4	227	c.142T>C	c.(142-144)TAT>CAT	p.Y48H		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	48	Pro-rich.					extracellular region				central_nervous_system(1)	1						CCCTTACCCATATCCATTTCG	0.393000													3	83					0	0	0.00024832	0	0
UNC5C	8633	broad.mit.edu	37	4	96166144	96166144	+	Silent	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:96166144A>G	uc003htp.1	-	6	1081	c.927T>C	c.(925-927)TGT>TGC	p.C309C	UNC5C_uc010ilc.1_Silent_p.C309C|UNC5C_uc003htq.2_Silent_p.C309C	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	309	Extracellular (Potential).|TSP type-1 1.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		ATAACGTAGTACAGGCTATTT	0.443000													11	58					0	0	0.000673444	0	0
NHEDC2	133308	broad.mit.edu	37	4	103966072	103966072	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:103966072A>G	uc003hwx.3	-	8	1843	c.971T>C	c.(970-972)ATT>ACT	p.I324T	NHEDC2_uc010iln.1_Missense_Mutation_p.I176T|NHEDC2_uc003hwy.2_Missense_Mutation_p.I324T|NHEDC2_uc011cew.1_Missense_Mutation_p.I267T|NHEDC2_uc011cex.1_Missense_Mutation_p.I267T	NM_178833	NP_849155	Q86UD5	NHDC2_HUMAN	Na+/H+ exchanger domain containing 2	324	Helical; (Potential).				sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity				0				OV - Ovarian serous cystadenocarcinoma(123;2.3e-08)		AAAGTACTGAATGAAAAATCC	0.373000													4	148					0	0	0.000602214	0	0
FHDC1	85462	broad.mit.edu	37	4	153896836	153896836	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:153896836C>G	uc003inf.2	+	11	2468	c.2393C>G	c.(2392-2394)CCG>CGG	p.P798R		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	798					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					GGCGGGGACCCGGAGGAAGGC	0.622000													3	55					0	0	6.4e-05	0	0
PDZD2	23037	broad.mit.edu	37	5	32000303	32000303	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr5:32000303G>T	uc003jhl.2	+	5	1568	c.1180G>T	c.(1180-1182)GGG>TGG	p.G394W	PDZD2_uc003jhm.2_Missense_Mutation_p.G394W|PDZD2_uc011cnx.1_Missense_Mutation_p.G220W	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	394	PDZ 2.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TTTACTGGTCGGGCTCTCCCA	0.527000													5	87					8.12818e-05	0.00234681	8.12818e-05	1	0
MCTP1	79772	broad.mit.edu	37	5	94050566	94050566	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr5:94050566T>C	uc003kkx.2	-	20	2636	c.2636A>G	c.(2635-2637)AAT>AGT	p.N879S	MCTP1_uc003kkv.2_Missense_Mutation_p.N658S|MCTP1_uc003kkw.2_Missense_Mutation_p.N572S|MCTP1_uc003kku.2_Missense_Mutation_p.N395S	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	879					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ATAGATTTTATTTATAAATCC	0.378000													13	85					0	0	0.000151284	0	0
IK	3550	broad.mit.edu	37	5	140037240	140037240	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr5:140037240G>A	uc003lgq.2	+	10	1013	c.903G>A	c.(901-903)AAG>AAA	p.K301K	IK_uc011czk.1_Silent_p.K301K	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	301					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAAGAAGAAGGATAAAGGTA	0.478000													17	33					0	0	0.000566183	0	0
RNF182	221687	broad.mit.edu	37	6	13977949	13977949	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:13977949G>A	uc003nbe.2	+	3	1017	c.599G>A	c.(598-600)GGA>GAA	p.G200E	RNF182_uc003nbf.2_Missense_Mutation_p.G200E|RNF182_uc003nbg.2_Missense_Mutation_p.G200E	NM_152737	NP_689950	Q8N6D2	RN182_HUMAN	ring finger protein 182	200	Helical; (Potential).					cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			TTACCCTTAGGAATCTACTTA	0.493000													37	46					0	0	0.000437636	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104341	26104341	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:26104341C>G	uc003ngi.2	+	1	166	c.166C>G	c.(166-168)CGA>GGA	p.R56G		NM_003542	NP_003533	P62805	H4_HUMAN	histone cluster 1, H4c	56					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0						TGAGGAGACTCGAGGTGTGCT	0.522000													9	28					0	0	0.000673444	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27101078	27101078	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:27101078G>C	uc003niw.2	+	1	262	c.228G>C	c.(226-228)AAG>AAC	p.K76N	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	76					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						ACAACAAGAAGACCCGCATCA	0.662000													4	35					0	0	0.00024832	0	0
TNF	7124	broad.mit.edu	37	6	31543638	31543638	+	Silent	SNP	C	T	T	rs141667614		TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:31543638C>T	uc003nui.2	+	1	289	c.120C>T	c.(118-120)ATC>ATT	p.I40I	TNF_uc003nuj.2_5'Flank	NM_000594	NP_000585	P01375	TNFA_HUMAN	tumor necrosis factor alpha	40	Helical; Signal-anchor for type II membrane protein; (Potential).				activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			ovary(1)|pancreas(1)|skin(1)	3		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	CCTTCCTGATCGTGGCAGGCG	0.657000									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				13	25					0	0	0.000566183	0	0
C6orf27	80737	broad.mit.edu	37	6	31743739	31743739	+	Splice_Site	SNP	A	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:31743739A>T	uc011dog.1	-	3	751	c.513_splice	c.e3+1	p.Q171_splice	C6orf27_uc003nxd.2_Intron|C6orf27_uc011doh.1_Splice_Site	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor							extracellular region				ovary(3)	3						CCCTGTTCTCACCTGCAGGGC	0.642000													32	52					0	0	0.000159656	0	0
HDAC2	3066	broad.mit.edu	37	6	114281154	114281154	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:114281154C>T	uc003pwd.1	-	2	363	c.363G>A	c.(361-363)CAG>CAA	p.Q121Q	HDAC2_uc003pwc.1_5'UTR|HDAC2_uc003pwe.1_5'UTR	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	27	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	TGGGATGACCCTGTCCATAAT	0.328000													29	49					0	0	0.000227799	0	0
RWDD1	51389	broad.mit.edu	37	6	116892810	116892810	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr6:116892810C>T	uc003pxd.2	+	1	228	c.65C>T	c.(64-66)TCC>TTC	p.S22F	RWDD1_uc003pxb.2_5'UTR|RWDD1_uc003pxc.2_5'UTR	NM_015952	NP_057036	Q9H446	RWDD1_HUMAN	RWD domain containing 1 isoform a	22	RWD.						protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		TACCCTGACTCCTTCACAGGT	0.647000													5	16					0	0	3.59834e-05	0	0
RPA3	6119	broad.mit.edu	37	7	7676650	7676651	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:7676650_7676651CC>AA	uc003sri.2	-	8	1518_1519	c.346_347GG>TT	c.(346-348)GGG>TTG	p.G116L	RPA3_uc003srh.2_Missense_Mutation_p.G77L	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	116					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		TTGCACAATCCCTAAAGGATAA	0.332000								Direct_reversal_of_damage|NER					19	505					0	0	6.4e-05	0	0
THSD7A	221981	broad.mit.edu	37	7	11676265	11676265	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:11676265T>C	uc003ssf.3	-	2	766	c.514A>G	c.(514-516)ATC>GTC	p.I172V		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	172	Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCACAGATGATATCCTCCGCA	0.498000										HNSCC(18;0.044)			14	104					0	0	0.000219431	0	0
EEPD1	80820	broad.mit.edu	37	7	36194142	36194142	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:36194142A>G	uc003tfa.2	+	2	849	c.209A>G	c.(208-210)TAT>TGT	p.Y70C		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	70					DNA repair		DNA binding				0						TACCGAGAGTATATCGGTGGC	0.592000													24	133					0	0	0.000586117	0	0
GLI3	2737	broad.mit.edu	37	7	42085000	42085000	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:42085000T>C	uc011kbh.1	-	6	900	c.809A>G	c.(808-810)TAT>TGT	p.Y270C	GLI3_uc011kbg.1_Missense_Mutation_p.Y211C	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	270					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						AGCATGAAGATATTCCATGTG	0.498000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				9	311					0	0	0.000274275	0	0
ABCA13	154664	broad.mit.edu	37	7	48313594	48313594	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:48313594T>C	uc003toq.2	+	17	4356	c.4331T>C	c.(4330-4332)ATA>ACA	p.I1444T	ABCA13_uc010kyr.2_Missense_Mutation_p.I947T	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1444					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GTGTTAAATATAAAAAAACCT	0.269000													5	172					0	0	3.59834e-05	0	0
MRPS17	51373	broad.mit.edu	37	7	56022640	56022641	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:56022640_56022641CC>AA	uc003trd.2	+	3	192_193	c.162_163CC>AA	c.(160-165)GCCCTT>GCAATT	p.L55I	MRPS17_uc003trb.2_Missense_Mutation_p.L150I	NM_015969	NP_057053	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17 precursor	55					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCACGATGCCCTTCAGCAGTG	0.436000													13	599					0	0	6.4e-05	0	0
BAZ1B	9031	broad.mit.edu	37	7	72856840	72856840	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:72856840T>C	uc003tyc.2	-	19	4483	c.4138A>G	c.(4138-4140)ATC>GTC	p.I1380V		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	1380	Bromo.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGGTGCGTGATCACATCATAG	0.522000													21	92					0	0	0.000375601	0	0
ABHD11	83451	broad.mit.edu	37	7	73150998	73150998	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:73150998A>G	uc003tzb.2	-	6	896	c.839T>C	c.(838-840)ATG>ACG	p.M280T	RFC2_uc011kfa.1_Intron|ABHD11_uc011kfb.1_Missense_Mutation_p.M223T|ABHD11_uc003tzc.2_Missense_Mutation_p.M273T|ABHD11_uc003tza.2_Missense_Mutation_p.M167T	NM_148912	NP_683710	Q8NFV4	ABHDB_HUMAN	abhydrolase domain containing 11 isoform 1	280							hydrolase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GAAGAGCCGCATAATCTCAGG	0.602000													13	37					0	0	0.000151284	0	0
WBSCR16	81554	broad.mit.edu	37	7	74482554	74482554	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:74482554T>C	uc003ubr.2	-	3	632	c.506A>G	c.(505-507)GAC>GGC	p.D169G	WBSCR16_uc010lca.2_5'Flank|WBSCR16_uc010lcb.1_Missense_Mutation_p.D169G	NM_030798	NP_110425	Q96I51	WBS16_HUMAN	Williams-Beuren syndrome chromosome region 16	169	RCC1 1.										0						CTGAGGTCTGTCCAGAGGCAG	0.567000													5	39					0	0	0.000602214	0	0
STYXL1	51657	broad.mit.edu	37	7	75625914	75625914	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:75625914A>C	uc003uej.3	-	9	987	c.814T>G	c.(814-816)TCC>GCC	p.S272A	STYXL1_uc003uef.2_Missense_Mutation_p.S62A|STYXL1_uc011kgf.1_Missense_Mutation_p.V96G|STYXL1_uc011kgg.1_Missense_Mutation_p.V86G|STYXL1_uc003ueh.2_Missense_Mutation_p.S134A|STYXL1_uc003uek.3_Missense_Mutation_p.S176A|STYXL1_uc003uel.2_Missense_Mutation_p.S272A|STYXL1_uc003uem.2_Missense_Mutation_p.S272A|TMEM120A_uc003ued.2_5'Flank|TMEM120A_uc003uee.2_5'Flank|TMEM120A_uc003uec.2_5'Flank	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	272	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						TAGGCCCAGGACCTCTATGAA	0.488000													11	52					0	0	0.000219431	0	0
SRRM3	222183	broad.mit.edu	37	7	75912381	75912381	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:75912381G>A	uc010ldi.2	+	14	1904	c.1695G>A	c.(1693-1695)CGG>CGA	p.R565R	SRRM3_uc003uet.1_5'UTR	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0						AGCGGCGCCGGGACTCGCCAA	0.746000													17	1					0	0	0.000175454	0	0
SGCE	8910	broad.mit.edu	37	7	94214819	94214819	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:94214819A>G	uc003unl.2	-	11	1417	c.1306T>C	c.(1306-1308)TAT>CAT	p.Y436H	SGCE_uc003unk.2_Missense_Mutation_p.Y259H|SGCE_uc003unm.2_Missense_Mutation_p.Y461H|SGCE_uc003unn.2_Silent_p.G438G|SGCE_uc011kic.1_Missense_Mutation_p.Y395H	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	436	Cytoplasmic (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTTCAGGGATACCATTTACCT	0.353000													79	417					0	0	0.000147903	0	0
MUC17	140453	broad.mit.edu	37	7	100685390	100685390	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:100685390A>G	uc003uxp.1	+	3	10746	c.10693A>G	c.(10693-10695)ACT>GCT	p.T3565A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3565	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGGTCACCACTATGCGTAT	0.468000													10	347					0	0	6.40141e-05	0	0
IFRD1	3475	broad.mit.edu	37	7	112096077	112096077	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:112096077G>C	uc003vgh.2	+	4	663	c.220G>C	c.(220-222)GAA>CAA	p.E74Q	IFRD1_uc011kmn.1_Missense_Mutation_p.E24Q|IFRD1_uc003vgi.2_Missense_Mutation_p.E74Q|IFRD1_uc003vgj.2_Missense_Mutation_p.E74Q|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.E24Q	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	74					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						CCTTGATGAGGAAGGAACTCA	0.358000													11	55					0	0	0.000151284	0	0
AHCYL2	23382	broad.mit.edu	37	7	129046309	129046309	+	Splice_Site	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:129046309T>C	uc011kov.1	+	10	1349	c.1295_splice	c.e10+2	p.C432_splice	AHCYL2_uc003vot.2_Splice_Site_p.C431_splice|AHCYL2_uc003vov.2_Splice_Site_p.C329_splice|AHCYL2_uc011kow.1_Splice_Site_p.C330_splice|AHCYL2_uc011kox.1_Splice_Site_p.C329_splice	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform						one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GCAAGCCTGGTAAGCCTCTAC	0.522000													10	77					0	0	0.000673444	0	0
STRA8	346673	broad.mit.edu	37	7	134925439	134925439	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:134925439T>C	uc011kpx.1	+	2	229	c.229T>C	c.(229-231)TAC>CAC	p.Y77H		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	77					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						GAAGACAGTGTACTCTCAGTC	0.612000													3	77					0	0	6.4e-05	0	0
MKRN1	23608	broad.mit.edu	37	7	140156594	140156594	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:140156594C>T	uc003vvt.2	-	5	1069	c.844G>A	c.(844-846)GGG>AGG	p.G282R	MKRN1_uc003vvs.2_Missense_Mutation_p.G218R|MKRN1_uc011krd.1_Missense_Mutation_p.G16R|MKRN1_uc003vvv.3_Missense_Mutation_p.G282R|MKRN1_uc003vvu.3_Missense_Mutation_p.G218R	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	282	RING-type.						ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					ATGCAGATCCCACACACCATG	0.552000													10	50					0	0	6.40141e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				71	20					0	0	0.000147903	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439579	150439579	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:150439579A>G	uc003whr.1	+	3	704	c.352A>G	c.(352-354)ATC>GTC	p.I118V	GIMAP5_uc010lpu.2_5'UTR	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	118	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTTCTGGTGATCCAGCTGGG	0.577000													10	80					0	0	6.40141e-05	0	0
KCNH2	3757	broad.mit.edu	37	7	150646050	150646050	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr7:150646050T>C	uc003wic.2	-	10	2499	c.2486A>G	c.(2485-2487)GAC>GGC	p.D829G	KCNH2_uc003wib.2_Missense_Mutation_p.D489G|KCNH2_uc011kux.1_Missense_Mutation_p.D733G	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	829	Cytoplasmic (Potential).|cNMP.				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	CTTGTGTAGGTCACAGTAGGT	0.577000													7	34					0	0	8.12818e-05	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1842704	1842704	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:1842704C>T	uc003wpr.2	+	13	1584	c.1406C>T	c.(1405-1407)TCC>TTC	p.S469F	ARHGEF10_uc003wpq.1_Missense_Mutation_p.S494F|ARHGEF10_uc003wps.2_Missense_Mutation_p.S431F|ARHGEF10_uc003wpt.2_Missense_Mutation_p.S345F|ARHGEF10_uc003wpv.2_Missense_Mutation_p.S202F|ARHGEF10_uc010lre.2_Missense_Mutation_p.S149F	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	494	DH.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GAGTGGGACTCCGTGGAAATG	0.552000													23	20					0	0	0.000720815	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767728	77767728	+	Silent	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:77767728G>A	uc003yav.2	+	10	8823	c.8436G>A	c.(8434-8436)ACG>ACA	p.T2812T	ZFHX4_uc003yau.1_Silent_p.T2857T|ZFHX4_uc003yaw.1_Silent_p.T2812T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2812						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CACCTACCACGGAGGTCTGCG	0.473000										HNSCC(33;0.089)			20	24					0	0	0.000375601	0	0
TG	7038	broad.mit.edu	37	8	133945820	133945820	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:133945820G>A	uc003ytw.2	+	24	4872	c.4831G>A	c.(4831-4833)GAG>AAG	p.E1611K	TG_uc010mdw.2_Missense_Mutation_p.E370K|TG_uc011ljb.1_Missense_Mutation_p.E44K	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1611	Type IIIA.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACAGAGGACGAGGCCTGCAG	0.577000													43	32					0	0	0.000147903	0	0
DENND3	22898	broad.mit.edu	37	8	142202749	142202749	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:142202749G>C	uc003yvy.2	+	22	3661	c.3383G>C	c.(3382-3384)CGG>CCG	p.R1128P	DENND3_uc010mep.2_Missense_Mutation_p.R1089P|DENND3_uc003ywa.1_Missense_Mutation_p.R178P|DENND3_uc003ywb.2_Missense_Mutation_p.R178P	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1128										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCATGATCCGGGTGAAGAAG	0.667000													3	68					0	0	0.00024832	0	0
GPR20	2843	broad.mit.edu	37	8	142366966	142366966	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:142366966G>C	uc003ywf.2	-	2	1147	c.1058C>G	c.(1057-1059)GCT>GGT	p.A353G		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	353	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			GGGCCCATTAGCCAGGGCCTG	0.627000													10	16					0	0	0.000442599	0	0
ZNF7	7553	broad.mit.edu	37	8	146068539	146068539	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr8:146068539A>G	uc003zeg.3	+	5	2184	c.2047A>G	c.(2047-2049)ATT>GTT	p.I683V	ZNF7_uc010mge.2_Missense_Mutation_p.I694V|ZNF7_uc011lln.1_Missense_Mutation_p.I587V|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.I587V|COMMD5_uc003zel.1_Intron	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	683	C2H2-type 15.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		GCATCAAAAAATTCACATGGG	0.343000													5	164					0	0	0.000274275	0	0
CBWD1	55871	broad.mit.edu	37	9	172083	172084	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr9:172083_172084GG>TT	uc003zga.3	-	4	533_534	c.427_428CC>AA	c.(427-429)CCT>AAT	p.P143N	CBWD1_uc003zgb.3_Missense_Mutation_p.P107N|CBWD1_uc003zgc.3_Missense_Mutation_p.P143N|CBWD1_uc011llr.1_Missense_Mutation_p.P107N	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1	143							ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTTCTTACCAGGGTCTGCTAAT	0.347000													13	278					0	0	6.4e-05	0	0
DENND4C	55667	broad.mit.edu	37	9	19361850	19361850	+	Silent	SNP	C	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr9:19361850C>T	uc003znq.2	+	25	4591	c.4558C>T	c.(4558-4560)CTG>TTG	p.L1520L	DENND4C_uc011lnc.1_Silent_p.L850L|DENND4C_uc011lnd.1_Silent_p.L808L|DENND4C_uc003znr.2_Silent_p.L808L|DENND4C_uc003zns.2_Silent_p.L702L	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1520						integral to membrane				ovary(1)|skin(1)	2						TTAGCTTCCTCTGTCATCTCT	0.363000													54	28					0	0	0.000147903	0	0
SLC31A2	1318	broad.mit.edu	37	9	115925079	115925079	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr9:115925079T>C	uc004bgq.2	+	4	431	c.314T>C	c.(313-315)GTC>GCC	p.V105A		NM_001860	NP_001851	O15432	COPT2_HUMAN	solute carrier family 31 (copper transporters),	105	Helical; (Potential).					integral to plasma membrane	copper ion transmembrane transporter activity				0						ATCCAGGTGGTCATCGGCTAC	0.473000													9	171					0	0	6.40141e-05	0	0
DAB2IP	153090	broad.mit.edu	37	9	124522284	124522284	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr9:124522284A>G	uc004bln.2	+	6	721	c.652A>G	c.(652-654)ACG>GCG	p.T218A	DAB2IP_uc004blo.2_Missense_Mutation_p.T122A	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	246	C2.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						TGCCCGCACCACGGGCAAGCT	0.597000													4	33					0	0	0.000602214	0	0
TLR7	51284	broad.mit.edu	37	X	12904178	12904178	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chrX:12904178A>T	uc004cvc.2	+	3	690	c.551A>T	c.(550-552)TAT>TTT	p.Y184F		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	184	LRR 6.|Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CAAAACTGTTATTATCGAAAT	0.378000													26	7					0	0	0.000117367	0	0
FANCB	2187	broad.mit.edu	37	X	14876022	14876022	+	Missense_Mutation	SNP	G	C	C	rs145542355	byFrequency	TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chrX:14876022G>C	uc004cwg.1	-	5	1427	c.1159C>G	c.(1159-1161)CGT>GGT	p.R387G	FANCB_uc004cwh.1_Missense_Mutation_p.R387G	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	387					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					ACCAGGTAACGATTCTCTTGT	0.323000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				3	142					0	0	0.00024832	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960020	117960020	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chrX:117960020C>G	uc004equ.2	+	4	1286	c.813C>G	c.(811-813)GAC>GAG	p.D271E		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						ATACCCTCGACGACTCCGATG	0.582000													31	5					0	0	0.000409698	0	0
BCORL1	63035	broad.mit.edu	37	X	129149266	129149266	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chrX:129149266T>C	uc004evb.1	+	4	2632	c.2518T>C	c.(2518-2520)TCT>CCT	p.S840P	BCORL1_uc010nrd.1_Missense_Mutation_p.S742P	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	840					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CCACCAGGCGTCTCTGCTTTC	0.612000													13	32					0	0	0.000308642	0	0
RNF169	254225	broad.mit.edu	37	11	74547223	74547223	+	Frame_Shift_Del	DEL	A	-	-			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr11:74547223delA	uc001ovl.3	+	6	1588	c.1575delA	c.(1573-1575)CCAfs	p.P525fs	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	525							zinc ion binding			ovary(1)	1						CTGAGATCCCACTGGAAACCT	0.488													21	71	---	---	---	---					
POLG	5428	broad.mit.edu	37	15	89876433	89876433	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr15:89876433delC	uc002bns.3	-	2	835	c.553delG	c.(553-555)GTAfs	p.V185fs	POLG_uc002bnr.3_Frame_Shift_Del_p.V185fs	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	185					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			GCCACGGGTACGGCCTCCCCC	0.716								DNA_polymerases_(catalytic_subunits)					5	6	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	G	G	rs113730440		TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr17:26684394_26684395insG	uc002haz.2	-	2	210	c.78_splice	c.e2+1	p.W26_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													4	5	---	---	---	---					
TRIOBP	11078	broad.mit.edu	37	22	38120323	38120325	+	In_Frame_Del	DEL	CCT	-	-			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr22:38120323_38120325delCCT	uc003atr.2	+	7	2031_2033	c.1760_1762delCCT	c.(1759-1764)GCCTCC>GCC	p.S589del	TRIOBP_uc003atu.2_In_Frame_Del_p.S417del|TRIOBP_uc003atq.1_In_Frame_Del_p.S589del|TRIOBP_uc003ats.1_In_Frame_Del_p.S417del	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	589					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAA	0.596													7	226	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-ER-A19B-06A-11D-A196-08	TCGA-ER-A19B-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	37a07820-df6e-4f43-9ce6-71f96e9dd46c	a86f5fe8-b66a-4c73-95eb-3e17a8b7bae1	g.chr4:1019055_1019056delCA	uc003gce.2	+	7	1596_1597	c.1435_1436delCA	c.(1435-1437)CACfs	p.H479fs	FGFRL1_uc003gcf.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc003gcg.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc010ibo.2_Frame_Shift_Del_p.H479fs	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.|Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.460													2	4	---	---	---	---					
