Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1751	85452	broad.mit.edu	37	1	1900131	1900131	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:1900131C>T	uc001aim.1	-	11	1344	c.1188G>A	c.(1186-1188)TGG>TGA	p.W396*	KIAA1751_uc009vkz.1_Nonsense_Mutation_p.W396*	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	396										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		AAATGTAGTTCCAGGTCTTGT	0.537													77	93					0	0	0.014410	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6527632	6527632	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:6527632C>T	uc001ano.1	-	22	3281	c.3180G>A	c.(3178-3180)TCG>TCA	p.S1060S	PLEKHG5_uc001ann.1_Silent_p.S1041S|PLEKHG5_uc001anq.1_Silent_p.S850S|PLEKHG5_uc001anp.1_Silent_p.S1081S|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Silent_p.S565S|PLEKHG5_uc009vma.1_Silent_p.S844S|PLEKHG5_uc010nzr.1_Silent_p.S1073S|PLEKHG5_uc001ank.1_Silent_p.S1004S|PLEKHG5_uc009vmb.1_3'UTR|PLEKHG5_uc001anl.1_Silent_p.S1004S|PLEKHG5_uc001anm.1_Silent_p.S1004S|PLEKHG5_uc001anr.1_3'UTR	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	1060					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CTCAGACCTCCCTACAGGGTG	0.632													22	88					0	0	0.004656	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6528517	6528517	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:6528517G>A	uc001ano.1	-	21	2648	c.2547C>T	c.(2545-2547)GCC>GCT	p.A849A	PLEKHG5_uc001ann.1_Silent_p.A830A|PLEKHG5_uc001anq.1_Intron|PLEKHG5_uc001anp.1_Silent_p.A870A|TNFRSF25_uc001ana.2_5'Flank|TNFRSF25_uc001anb.2_5'Flank|TNFRSF25_uc001anc.2_5'Flank|TNFRSF25_uc001and.2_5'Flank|TNFRSF25_uc009vlz.2_5'Flank|TNFRSF25_uc001ane.2_5'Flank|TNFRSF25_uc001anf.2_5'Flank|TNFRSF25_uc001ang.2_5'Flank|TNFRSF25_uc001anh.2_5'Flank|TNFRSF25_uc001ani.1_5'Flank|PLEKHG5_uc001anj.1_Silent_p.A354A|PLEKHG5_uc009vma.1_Silent_p.A633A|PLEKHG5_uc010nzr.1_Silent_p.A862A|PLEKHG5_uc001ank.1_Silent_p.A793A|PLEKHG5_uc009vmb.1_Silent_p.A793A|PLEKHG5_uc001anl.1_Silent_p.A793A|PLEKHG5_uc001anm.1_Silent_p.A793A|PLEKHG5_uc001anr.1_Silent_p.A56A	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	849					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TGGCAGATGAGGCAGTGGTGC	0.647													10	13					0	0	0.006214	0	0
PHF13	148479	broad.mit.edu	37	1	6680321	6680321	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:6680321C>T	uc001aob.3	+	3	971	c.600C>T	c.(598-600)ATC>ATT	p.I200I		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	PHD finger protein 13	200					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		AACGGACTATCGTCCGGCAGG	0.537													14	31					0	0	0.001855	0	0
PIK3CD	5293	broad.mit.edu	37	1	9787030	9787030	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:9787030G>A	uc001aqb.3	+	24	3269	c.3061G>A	c.(3061-3063)GAA>AAA	p.E1021K	PIK3CD_uc010oaf.1_Missense_Mutation_p.E1020K|PIK3CD_uc001aqe.3_Missense_Mutation_p.E1045K	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	1021	PI3K/PI4K.				phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GAAGTTTAACGAAGCCCTCCG	0.567													20	19					0	0	0.010504	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561454	11561454	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:11561454G>A	uc001ash.3	+	2	543	c.405G>A	c.(403-405)CGG>CGA	p.R135R	PTCHD2_uc001asi.1_Silent_p.R135R	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	135	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCTGGGGGCGGAACCGGCGCG	0.607													18	33					0	0	0.006122	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12856118	12856118	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:12856118G>A	uc001auj.1	+	4	1501	c.1398G>A	c.(1396-1398)GAG>GAA	p.E466E		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	466											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACCGTCTGAGGAACTGGAGC	0.542													10	79					0	0	0.002450	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921607	12921607	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:12921607G>A	uc001aum.1	+	4	1485	c.1398G>A	c.(1396-1398)GAG>GAA	p.E466E		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	466											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACCGTCTGAGGAACTGGAGC	0.537													8	42					0	0	0.007413	0	0
PRAMEF18	391003	broad.mit.edu	37	1	13695858	13695858	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:13695858G>A	uc009vny.1	-	3	1154	c.1107C>T	c.(1105-1107)ATC>ATT	p.I369I		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	369											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCAGGCAGGATGACCCTGA	0.567													100	112					0	0	0.014410	0	0
SPEN	23013	broad.mit.edu	37	1	16245992	16245992	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:16245992C>A	uc001axk.1	+	8	1819	c.1615C>A	c.(1615-1617)CGA>AGA	p.R539R	SPEN_uc010obp.1_Silent_p.R498R	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	539	RRM 4.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACATTTCTGCCGATATGGGCC	0.468													6	155					0.00198382	0.00622622	0.001984	1	0
NBPF1	55672	broad.mit.edu	37	1	16892226	16892226	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:16892226G>A	uc009vos.1	-	28	4079	c.3191C>T	c.(3190-3192)CCT>CTT	p.P1064L	uc001ayw.2_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	1064	NBPF 7.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACAACTGGAAGGAGTTGAATA	0.473													49	684					0	0	0.014410	0	0
UBXN10	127733	broad.mit.edu	37	1	20517366	20517366	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:20517366C>T	uc001bdb.2	+	2	396	c.312C>T	c.(310-312)CCC>CCT	p.P104P		NM_152376	NP_689589	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	104										ovary(1)	1						AGCAAGTACCCACTGGGGCTT	0.522													46	39					0	0	0.014410	0	0
EPHB2	2048	broad.mit.edu	37	1	23208887	23208887	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:23208887C>T	uc009vqj.1	+	6	1484	c.1339C>T	c.(1339-1341)CGC>TGC	p.R447C	EPHB2_uc001bge.2_Missense_Mutation_p.R447C|EPHB2_uc001bgf.2_Missense_Mutation_p.R447C|EPHB2_uc010odu.1_Missense_Mutation_p.R447C	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	447	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TCAGGTGAGCCGCACCGTGGA	0.587									Hereditary_Prostate_Cancer				9	40					0	0	0.006214	0	0
IL28RA	163702	broad.mit.edu	37	1	24484058	24484058	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:24484058G>A	uc001bis.2	-	7	1138	c.1125C>T	c.(1123-1125)GTC>GTT	p.V375V	IL28RA_uc001bir.2_Silent_p.V346V|IL28RA_uc001bit.2_3'UTR|IL28RA_uc001biu.2_Silent_p.V291V	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	375	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		CTTCGCTTGGGACCAGAGGAG	0.622													18	15					0	0	0.004990	0	0
SNRNP40	9410	broad.mit.edu	37	1	31744311	31744311	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:31744311G>A	uc001bso.2	-	6	736	c.690C>T	c.(688-690)ACC>ACT	p.T230T	SNRNP40_uc009vtt.2_5'Flank|SNRNP40_uc010oge.1_Silent_p.T230T	NM_004814	NP_004805	Q96DI7	SNR40_HUMAN	WD repeat domain 57 (U5 snRNP specific)	230	WD 4.					catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding				0						GGCCTCTCATGGTGTAGGTTA	0.438													59	45					0	0	0.014410	0	0
SPOCD1	90853	broad.mit.edu	37	1	32265727	32265727	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:32265727G>A	uc001bts.1	-	5	1676	c.1618C>T	c.(1618-1620)CCT>TCT	p.P540S	SPOCD1_uc001btt.2_5'Flank|SPOCD1_uc001btu.2_Missense_Mutation_p.P540S|SPOCD1_uc001btv.2_Missense_Mutation_p.P33S|SPOCD1_uc001btw.1_5'Flank	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	540					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CCTCCTGAAGGAGAAGGCTGG	0.642													9	5					0	0	0.004482	0	0
C1orf91	56063	broad.mit.edu	37	1	32682831	32682831	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:32682831C>T	uc009vub.1	-	4	360	c.357G>A	c.(355-357)ACG>ACA	p.T119T	C1orf91_uc001buo.3_Intron|C1orf91_uc001bup.3_Intron|C1orf91_uc010oha.1_Intron|C1orf91_uc001buq.3_Intron			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	Error:Variant_position_missing_in_Q8WY98_after_alignment						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CACAGAGCTGCGTCCCGCACT	0.517													9	26					0	0	0.006214	0	0
GJB3	2707	broad.mit.edu	37	1	35251051	35251051	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:35251051T>C	uc001bxx.2	+	2	1303	c.688T>C	c.(688-690)TCG>CCG	p.S230P	GJB3_uc001bxy.2_Missense_Mutation_p.S230P|GJB3_uc001bxz.3_Missense_Mutation_p.S230P|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	230	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TTGCAGCCCCTCGTCCTCCGC	0.632													8	15					0	0	0.003080	0	0
EIF2C1	26523	broad.mit.edu	37	1	36383199	36383199	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:36383199C>T	uc001bzl.2	+	16	2247	c.2034C>T	c.(2032-2034)CTC>CTT	p.L678L	EIF2C1_uc001bzk.2_Silent_p.L603L|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	678	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCTAGATACTCCACTATGAGC	0.448													37	110					0	0	0.007835	0	0
GRIK3	2899	broad.mit.edu	37	1	37271706	37271706	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:37271706C>T	uc001caz.2	-	14	2448	c.2313G>A	c.(2311-2313)ATG>ATA	p.M771I	GRIK3_uc001cba.1_Missense_Mutation_p.M771I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	771	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CTCGCTCACCCATGGGCGTGC	0.652													12	17					0	0	0.003163	0	0
ZNF643	65243	broad.mit.edu	37	1	40928144	40928144	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:40928144C>T	uc001cfn.1	+	5	785	c.488C>T	c.(487-489)TCG>TTG	p.S163L	ZNF643_uc001cfl.1_Missense_Mutation_p.S61L|ZNF643_uc001cfm.1_Missense_Mutation_p.S29L	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			AATGATATTTCGTGGGAAGAA	0.338													103	102					0	0	0.014410	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047905	42047905	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:42047905A>G	uc001cgz.3	-	4	3777	c.2564T>C	c.(2563-2565)GTT>GCT	p.V855A	HIVEP3_uc001cha.3_Missense_Mutation_p.V855A|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	855	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Glu/Pro-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GATCTCAGGAACCTGAATGTT	0.612													30	93					0	0	0.012213	0	0
WDR65	149465	broad.mit.edu	37	1	43649360	43649360	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:43649360C>T	uc001cip.1	+	4	694	c.573C>T	c.(571-573)AGC>AGT	p.S191S	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Silent_p.S180S|WDR65_uc001ciq.1_Silent_p.S191S	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65	191										skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGCAAACCAGCTTTCAGAGGG	0.488													21	62					0	0	0.010504	0	0
KIAA0467	23334	broad.mit.edu	37	1	43891205	43891205	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:43891205C>T	uc001cjk.1	+	5	642	c.180C>T	c.(178-180)CTC>CTT	p.L60L	KIAA0467_uc009vws.1_Silent_p.L902L	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	902						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACTCAGAGCTCAATCTGGTCA	0.557													27	91					0	0	0.006320	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120229	46120229	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:46120229C>T	uc001coq.2	-	6	1824	c.463G>A	c.(463-465)GAA>AAA	p.E155K		NM_021639	NP_067652	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TCCTCCTCTTCAAACTGCAAC	0.408													26	70					0	0	0.007291	0	0
TMEM61	199964	broad.mit.edu	37	1	55451846	55451846	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:55451846G>A	uc001cyd.2	+	2	366	c.92G>A	c.(91-93)GGG>GAG	p.G31E		NM_182532	NP_872338	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	31	Helical; (Potential).					integral to membrane					0						CTGGTGGCCGGGACGCTCTGC	0.657													30	21					0	0	0.009535	0	0
OMA1	115209	broad.mit.edu	37	1	58946724	58946724	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:58946724C>T	uc001cyy.2	-	9	1576	c.1488G>A	c.(1486-1488)ACG>ACA	p.T496T	DAB1_uc001cyt.1_Intron|OMA1_uc001cyx.1_Intron	NM_145243	NP_660286	Q96E52	OMA1_HUMAN	OMA1 homolog, zinc metallopeptidase precursor	496					proteolysis	integral to membrane|mitochondrial membrane	metal ion binding|metalloendopeptidase activity			large_intestine(1)	1	all_cancers(7;6.54e-05)					TCTGTTTCTTCGTGATATTTA	0.353													59	55					0	0	0.014410	0	0
UBE2U	148581	broad.mit.edu	37	1	64698315	64698315	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:64698315A>G	uc001dbn.1	+	7	822	c.578A>G	c.(577-579)GAA>GGA	p.E193G		NM_152489	NP_689702	Q5VVX9	UBE2U_HUMAN	ubiquitin-conjugating enzyme E2U (putative)	193							ATP binding|protein binding|ubiquitin-protein ligase activity				0						AAAGCCACAGAATACTACAGA	0.328													18	66					0	0	0.007413	0	0
DNAJC6	9829	broad.mit.edu	37	1	65860679	65860679	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:65860679C>T	uc001dcd.1	+	13	1995	c.1831C>T	c.(1831-1833)CTC>TTC	p.L611F	DNAJC6_uc010opc.1_Missense_Mutation_p.L598F|DNAJC6_uc001dce.1_Missense_Mutation_p.L668F	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	611	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						TGACCCCTTTCTCCAGCCAAC	0.443													33	105					0	0	0.003755	0	0
WLS	79971	broad.mit.edu	37	1	68591997	68591997	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:68591997C>T	uc001def.1	-	12	1809	c.1538G>A	c.(1537-1539)GGG>GAG	p.G513E	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Intron|WLS_uc001deg.1_Missense_Mutation_p.G422E|WLS_uc009wbf.1_3'UTR	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	513	Cytoplasmic (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						GAGTTCTTCCCCACTATGGAC	0.552													11	26					0	0	0.001855	0	0
PTGFR	5737	broad.mit.edu	37	1	78958951	78958951	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:78958951C>T	uc001din.2	+	2	789	c.523C>T	c.(523-525)CGA>TGA	p.R175*	PTGFR_uc001dim.2_Nonsense_Mutation_p.R175*	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	175	Helical; Name=4; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CCTTGGACATCGAGACTATAA	0.373													64	77					0	0	0.014410	0	0
BTBD8	284697	broad.mit.edu	37	1	92554331	92554331	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:92554331C>T	uc001doo.2	+	2	493	c.226C>T	c.(226-228)CTT>TTT	p.L76F	BTBD8_uc010otc.1_RNA	NM_183242	NP_899065	Q5XKL5	BTBD8_HUMAN	BTB (POZ) domain containing 8	76	BTB 1.					nucleus				ovary(1)	1		all_lung(203;0.0484)|Lung NSC(277;0.126)|Glioma(108;0.222)		all cancers(265;0.0153)|Epithelial(280;0.0982)		CAAAGCAGTCCTTTTAGCAAG	0.368													28	78					0	0	0.007291	0	0
RPL5	6125	broad.mit.edu	37	1	93298955	93298955	+	Nonsense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:93298955A>T	uc001doz.2	+	2	91	c.13A>T	c.(13-15)AAA>TAA	p.K5*	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_5'UTR|RPL5_uc001dpd.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	5					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		GGGGTTTGTTAAAGTTGTTAA	0.299													48	42					0	0	0.014410	0	0
ABCA4	24	broad.mit.edu	37	1	94502706	94502706	+	Missense_Mutation	SNP	C	T	T	rs61752425		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:94502706C>T	uc001dqh.2	-	25	3912	c.3808G>A	c.(3808-3810)GAA>AAA	p.E1270K		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1270	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTTACCTCTTCCAGGGGAGTG	0.453													57	50					0	0	0.014410	0	0
SORT1	6272	broad.mit.edu	37	1	109884743	109884744	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:109884743_109884744CC>AA	uc001dxm.1	-	9	1049_1050	c.1000_1001GG>TT	c.(1000-1002)GGG>TTG	p.G334L	SORT1_uc010ovi.1_Missense_Mutation_p.G197L	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	334	BNR 5.|Extracellular (Potential).				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		CCATGTGTCCCCTTGATCTGTT	0.446													13	744					0	0	0.004672	0	0
CHI3L2	1117	broad.mit.edu	37	1	111783990	111783990	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:111783990G>A	uc001eam.2	+	9	1031	c.960G>A	c.(958-960)CAG>CAA	p.Q320Q	CHI3L2_uc001ean.2_Silent_p.Q310Q|CHI3L2_uc001eao.2_Silent_p.Q241Q|CHI3L2_uc009wga.2_Intron	NM_004000	NP_003991	Q15782	CH3L2_HUMAN	chitinase 3-like 2 isoform a	320					chitin catabolic process	extracellular space	cation binding|chitinase activity			central_nervous_system(1)	1		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		CGCGGCTCCAGGATCAACAGG	0.532													34	34					0	0	0.013726	0	0
PTGFRN	5738	broad.mit.edu	37	1	117487403	117487403	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:117487403C>T	uc001egv.1	+	3	658	c.521C>T	c.(520-522)GCC>GTC	p.A174V		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	174	Ig-like C2-type 2.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GCCGCCTCCGCCTCGCCGCTG	0.781													3	2					0	0	0.004672	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144886256	144886256	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:144886256G>T	uc001elw.3	-	23	3269	c.2978C>A	c.(2977-2979)CCG>CAG	p.P993Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.P1059Q|PDE4DIP_uc001elv.3_5'UTR	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	993					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCCTCCCATCGGAGAAGGAGG	0.488			T	PDGFRB	MPD								7	317					0.00307968	0.00962559	0.003080	1	0
GJA5	2702	broad.mit.edu	37	1	147230938	147230938	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:147230938C>T	uc001eps.1	-	2	550	c.409G>A	c.(409-411)GAG>AAG	p.E137K	GJA5_uc001ept.1_Missense_Mutation_p.E137K	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	137	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TTCCCTTCCTCCCAGCAGGAC	0.607													16	44					0	0	0.003163	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149858185	149858185	+	Silent	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:149858185A>G	uc001etc.2	-	1	48	c.6T>C	c.(4-6)CCT>CCC	p.P2P	HIST2H2AC_uc001etd.2_5'Flank	NM_003528	NP_003519	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	2					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTGCCGGTTCAGGCATGGTAA	0.512													11	22					0	0	0.008291	0	0
SETDB1	9869	broad.mit.edu	37	1	150921900	150921900	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:150921900C>T	uc001evu.2	+	12	1669	c.1479C>T	c.(1477-1479)TCC>TCT	p.S493S	SETDB1_uc009wmf.2_Silent_p.S494S|SETDB1_uc001evv.2_Silent_p.S493S|SETDB1_uc009wmg.1_Silent_p.S493S	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGAGCACGTCCTTTCGACCAG	0.498													41	79					0	0	0.011902	0	0
SEMA6C	10500	broad.mit.edu	37	1	151108200	151108200	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:151108200G>A	uc001ewu.2	-	14	1600	c.1300C>T	c.(1300-1302)CCC>TCC	p.P434S	SEMA6C_uc001ewv.2_Missense_Mutation_p.P434S|SEMA6C_uc001eww.2_Missense_Mutation_p.P394S|SEMA6C_uc010pcq.1_Missense_Mutation_p.P434S	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	434	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTACTGTGGGGACCAGCCATG	0.582													16	36					0	0	0.003163	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058027	152058027	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152058027C>T	uc001ezo.1	-	3	2196	c.2131G>A	c.(2131-2133)GGA>AGA	p.G711R		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	711							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTTGCTCTTCCTTTCTCTTCT	0.443													66	70					0	0	0.014410	0	0
HRNR	388697	broad.mit.edu	37	1	152185756	152185756	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152185756G>A	uc001ezt.1	-	3	8425	c.8349C>T	c.(8347-8349)TCC>TCT	p.S2783S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2783	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCGTAGCTGGAAGACTGCC	0.567													8	28					0	0	0.001855	0	0
FLG	2312	broad.mit.edu	37	1	152277655	152277655	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152277655G>A	uc001ezu.1	-	3	9743	c.9707C>T	c.(9706-9708)TCC>TTC	p.S3236F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3236	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGTTTCTGGAAGCAGACCC	0.597									Ichthyosis				53	122					0	0	0.014410	0	0
FLG	2312	broad.mit.edu	37	1	152282067	152282067	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152282067G>A	uc001ezu.1	-	3	5331	c.5295C>T	c.(5293-5295)TTC>TTT	p.F1765F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1765	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGGTAGAGGAAAGACCCTG	0.612									Ichthyosis				67	95					0	0	0.014410	0	0
FLG	2312	broad.mit.edu	37	1	152283067	152283067	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152283067C>T	uc001ezu.1	-	3	4331	c.4295G>A	c.(4294-4296)GGG>GAG	p.G1432E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1432	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGCTTTCCCCTGACTGGCC	0.567									Ichthyosis				66	89					0	0	0.014410	0	0
FLG2	388698	broad.mit.edu	37	1	152327955	152327955	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:152327955G>A	uc001ezw.3	-	3	2380	c.2307C>T	c.(2305-2307)AGC>AGT	p.S769S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	769	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGGCCATAGCTAGACTGAC	0.517													9	284					0	0	0.006214	0	0
SHC1	6464	broad.mit.edu	37	1	154941262	154941262	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:154941262C>A	uc001ffv.2	-	3	836	c.615G>T	c.(613-615)GCG>GCT	p.A205A	SHC1_uc001ffz.1_5'Flank|SHC1_uc001ffw.2_Silent_p.A205A|SHC1_uc001ffx.2_Silent_p.A95A|SHC1_uc001ffy.2_Silent_p.A95A	NM_183001	NP_892113	P29353	SHC1_HUMAN	SHC-transforming protein 1 isoform 1	205	PID.				activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(1)|skin(1)	2	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCTCCTTGTCGCCCCCTTAG	0.637													38	42					2.01872e-29	6.48852e-29	0.014410	1	0
FCRL4	83417	broad.mit.edu	37	1	157556119	157556119	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:157556119C>T	uc001fqw.2	-	6	1110	c.974G>A	c.(973-975)CGA>CAA	p.R325Q	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	325	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CATGTCCTCTCGGTGCCAGGA	0.607													19	37					0	0	0.007413	0	0
CD1B	910	broad.mit.edu	37	1	158300748	158300748	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:158300748G>A	uc001frx.2	-	2	274	c.166C>T	c.(166-168)CAT>TAT	p.H56Y	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Missense_Mutation_p.H56Y	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	56	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					TCCCAGCCATGAATCTGCAAA	0.493													103	199					0	0	0.014410	0	0
OR10R2	343406	broad.mit.edu	37	1	158450327	158450327	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:158450327C>T	uc010pik.1	+	1	660	c.660C>T	c.(658-660)TTC>TTT	p.F220F	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	220	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTGTGATATTCATTTGTGGAG	0.408													41	86					0	0	0.009718	0	0
SPTA1	6708	broad.mit.edu	37	1	158604457	158604457	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:158604457T>G	uc001fst.1	-	39	5640	c.5441A>C	c.(5440-5442)AAG>ACG	p.K1814T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1814	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TTCTTCCAACTTAAGTCCTCT	0.463													11	43					0	0	0.008291	0	0
PBX1	5087	broad.mit.edu	37	1	164769100	164769100	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:164769100C>T	uc001gct.2	+	4	933	c.675C>T	c.(673-675)ATC>ATT	p.I225I	PBX1_uc010pku.1_Silent_p.I225I|PBX1_uc010pkv.1_Silent_p.I142I|PBX1_uc001gcs.2_Silent_p.I225I|PBX1_uc010pkw.1_Silent_p.I115I	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	225					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						CGGTGATGATCCTGCGTTCCC	0.612			T	TCF3|EWSR1	pre B-ALL|myoepithelioma								12	23					0	0	0.010729	0	0
CREG1	8804	broad.mit.edu	37	1	167515488	167515488	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:167515488G>A	uc001gel.2	-	3	587	c.509C>T	c.(508-510)TCG>TTG	p.S170L		NM_003851	NP_003842	O75629	CREG1_HUMAN	cellular repressor of E1A-stimulated genes	170					cell proliferation|multicellular organismal development|regulation of growth|regulation of transcription from RNA polymerase II promoter	extracellular region	FMN binding|transcription corepressor activity				0						AATGAATAACGAATGCTTTGC	0.353													26	33					0	0	0.005443	0	0
DNM3	26052	broad.mit.edu	37	1	172011255	172011255	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:172011255C>T	uc001gie.2	+	8	1275	c.1099C>T	c.(1099-1101)CAT>TAT	p.H367Y	DNM3_uc001gid.3_Missense_Mutation_p.H367Y|DNM3_uc009wwb.2_Missense_Mutation_p.H367Y|DNM3_uc001gif.2_Missense_Mutation_p.H367Y	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	367					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						TCGTATTTTTCATGAACGCTT	0.358													23	39					0	0	0.012319	0	0
FASLG	356	broad.mit.edu	37	1	172634971	172634971	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:172634971G>A	uc001gis.2	+	4	818	c.661G>A	c.(661-663)GAT>AAT	p.D221N	FASLG_uc001git.2_3'UTR	NM_000639	NP_000630	P48023	TNFL6_HUMAN	fas ligand	221	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3						GTATCCCCAGGATCTGGTGAT	0.517													24	67					0	0	0.007291	0	0
SLC9A11	284525	broad.mit.edu	37	1	173493180	173493180	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:173493180G>A	uc001giz.2	-	21	2991	c.2568C>T	c.(2566-2568)CCC>CCT	p.P856P	SLC9A11_uc009wwe.2_Silent_p.P414P	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	856					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						CAGGAGTTGGGGGTGGGATTG	0.313													30	65					0	0	0.013726	0	0
SLC9A11	284525	broad.mit.edu	37	1	173567103	173567103	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:173567103T>A	uc001giz.2	-	4	720	c.297A>T	c.(295-297)TTA>TTT	p.L99F	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	99	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TAAATATAATTAAAGGTGAAA	0.303													47	69					0	0	0.014410	0	0
TNR	7143	broad.mit.edu	37	1	175304902	175304902	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:175304902C>T	uc001gkp.1	-	18	3657	c.3576G>A	c.(3574-3576)CGG>CGA	p.R1192R	TNR_uc009wwu.1_Silent_p.R1192R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1192	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CAGCCCATTTCCGGAAAAAAT	0.393													35	61					0	0	0.004878	0	0
PAPPA2	60676	broad.mit.edu	37	1	176526248	176526248	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:176526248T>C	uc001gkz.2	+	2	1954	c.790T>C	c.(790-792)TAC>CAC	p.Y264H	PAPPA2_uc001gky.1_Missense_Mutation_p.Y264H|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	264					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCCCATCTTATACTTCTCTGG	0.572													12	25					0	0	0.013537	0	0
FAM5B	57795	broad.mit.edu	37	1	177250484	177250484	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:177250484G>A	uc001glf.2	+	8	2484	c.2172G>A	c.(2170-2172)AGG>AGA	p.R724R	FAM5B_uc001glg.2_Silent_p.R619R	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	724						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TTGAGCTCAGGGACCGGGTGA	0.537													27	47					0	0	0.005443	0	0
ABL2	27	broad.mit.edu	37	1	179095764	179095764	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:179095764C>T	uc001gmj.3	-	4	722	c.435G>A	c.(433-435)TGG>TGA	p.W145*	ABL2_uc010pnf.1_Nonsense_Mutation_p.W145*|ABL2_uc010png.1_Nonsense_Mutation_p.W124*|ABL2_uc010pnh.1_Nonsense_Mutation_p.W124*|ABL2_uc009wxe.2_Nonsense_Mutation_p.W124*|ABL2_uc001gmg.3_Nonsense_Mutation_p.W130*|ABL2_uc001gmi.3_Nonsense_Mutation_p.W130*|ABL2_uc001gmh.3_Nonsense_Mutation_p.W109*|ABL2_uc010pne.1_Nonsense_Mutation_p.W109*|ABL2_uc009wxf.1_Nonsense_Mutation_p.W130*|ABL2_uc001gmk.2_Nonsense_Mutation_p.W109*	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	145	SH3.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAACTTCACTCCACTCACCAT	0.473			T	ETV6	AML								26	16					0	0	0.005443	0	0
CACNA1E	777	broad.mit.edu	37	1	181620575	181620575	+	Silent	SNP	C	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:181620575C>G	uc001gow.2	+	7	1218	c.1053C>G	c.(1051-1053)TCC>TCG	p.S351S	CACNA1E_uc009wxr.2_Silent_p.S258S|CACNA1E_uc009wxs.2_Silent_p.S258S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	351	Cytoplasmic (Potential).|I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAGTGCTTTCCGGGTGAGCCA	0.448													3	88					0	0	0.004672	0	0
SMG7	9887	broad.mit.edu	37	1	183502837	183502837	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:183502837T>C	uc001gqg.2	+	10	1155	c.1033T>C	c.(1033-1035)TGT>CGT	p.C345R	SMG7_uc010pob.1_Missense_Mutation_p.C374R|SMG7_uc001gqf.2_Missense_Mutation_p.C345R|SMG7_uc001gqh.2_Missense_Mutation_p.C345R|SMG7_uc001gqi.2_Missense_Mutation_p.C303R|SMG7_uc010poc.1_Missense_Mutation_p.C303R	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	345					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding	p.C345Y(1)		upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CCTGTGCAAGTGTCCTCTACA	0.413													17	41					0	0	0.004990	0	0
KIF21B	23046	broad.mit.edu	37	1	200967659	200967659	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:200967659C>T	uc001gvs.1	-	14	2247	c.1930G>A	c.(1930-1932)GAA>AAA	p.E644K	KIF21B_uc001gvr.1_Missense_Mutation_p.E644K|KIF21B_uc009wzl.1_Missense_Mutation_p.E644K|KIF21B_uc010ppn.1_Missense_Mutation_p.E644K	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	644	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						TGCTTGATTTCGATCTCACAA	0.567													30	39					0	0	0.008361	0	0
CACNA1S	779	broad.mit.edu	37	1	201052399	201052399	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:201052399G>A	uc001gvv.2	-	10	1511	c.1284C>T	c.(1282-1284)ATC>ATT	p.I428I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	428	II.|Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGGACTTCACGATGTCATGGC	0.562													31	44					0	0	0.013726	0	0
RNPEP	6051	broad.mit.edu	37	1	201970811	201970811	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:201970811C>T	uc001gxd.2	+	8	1371	c.1342C>T	c.(1342-1344)CGA>TGA	p.R448*	RNPEP_uc001gxe.2_Nonsense_Mutation_p.R149*|RNPEP_uc001gxf.2_Nonsense_Mutation_p.R317*	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	448					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		ATTCAAATTCCGAAGCATCTT	0.493													67	81					0	0	0.014410	0	0
CNTN2	6900	broad.mit.edu	37	1	205028341	205028341	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:205028341C>T	uc001hbr.2	+	6	886	c.617C>T	c.(616-618)TCC>TTC	p.S206F	CNTN2_uc001hbq.1_Missense_Mutation_p.S97F|CNTN2_uc009xbi.2_Missense_Mutation_p.S97F|CNTN2_uc001hbs.2_5'UTR	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	206	Ig-like C2-type 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGCAACTACTCCTGTTTGGCC	0.582													8	18					0	0	0.004482	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209950801	209950801	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:209950801C>T	uc001hho.2	+	12	1448	c.1158C>T	c.(1156-1158)GAC>GAT	p.D386D	TRAF3IP3_uc001hhl.2_Silent_p.D366D|TRAF3IP3_uc001hhm.1_Intron|TRAF3IP3_uc001hhn.2_Silent_p.D366D|TRAF3IP3_uc009xcr.2_Silent_p.D386D	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	386	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GGGACAGAGACCTGTGCAGCT	0.512													10	27					0	0	0.008291	0	0
SPATA17	128153	broad.mit.edu	37	1	217947879	217947879	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:217947879G>A	uc001hlh.1	+	7	749	c.723G>A	c.(721-723)CAG>CAA	p.Q241Q	SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Silent_p.Q241Q	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	241						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		AGCAATGTCAGGTACTAGTTT	0.308													12	10					0	0	0.010729	0	0
C1orf65	164127	broad.mit.edu	37	1	223568396	223568396	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:223568396G>A	uc001hoa.2	+	1	1682	c.1579G>A	c.(1579-1581)GAC>AAC	p.D527N		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	527										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GACCACTAGGGACAAGGTGCA	0.542													18	33					0	0	0.012319	0	0
CAPN2	824	broad.mit.edu	37	1	223939704	223939704	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:223939704C>T	uc001hob.3	+	8	1129	c.905C>T	c.(904-906)CCA>CTA	p.P302L	CAPN2_uc010puy.1_Missense_Mutation_p.P224L	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	302	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		TCCAGCTGCCCAAGCTGGAAC	0.507													16	22					0	0	0.004007	0	0
MIXL1	83881	broad.mit.edu	37	1	226413317	226413317	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:226413317C>T	uc010pvm.1	+	2	503	c.503C>T	c.(502-504)ACG>ATG	p.T168M		NM_031944	NP_114150	Q9H2W2	MIXL1_HUMAN	Mix-like homeobox protein 1	168					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.109)		GGAACTGAAACGAAATGTCTG	0.557													14	39					0	0	0.002450	0	0
CABC1	56997	broad.mit.edu	37	1	227152968	227152968	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:227152968C>T	uc001hqm.1	+	8	3864	c.445C>T	c.(445-447)CCC>TCC	p.P149S	CABC1_uc010pvp.1_Missense_Mutation_p.P112S|CABC1_uc001hqn.1_Missense_Mutation_p.P149S|CABC1_uc009xeq.1_Missense_Mutation_p.P97S|CABC1_uc010pvq.1_Intron|CABC1_uc010pvr.1_5'Flank	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	149					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CTTTGCAAACCCCAGAGACTC	0.627													7	14					0	0	0.003080	0	0
C1orf198	84886	broad.mit.edu	37	1	230979419	230979419	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:230979419G>A	uc001hub.2	-	3	652	c.608C>T	c.(607-609)CCT>CTT	p.P203L	C1orf198_uc009xfh.1_Missense_Mutation_p.P73L|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.P165L	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	203											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CTCGGCCTCAGGCCCCTCCCC	0.642													25	22					0	0	0.003954	0	0
DISC1	27185	broad.mit.edu	37	1	231954099	231954099	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:231954099A>T	uc001huz.2	+	9	1870	c.1817A>T	c.(1816-1818)GAC>GTC	p.D606V	TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.D595V|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.D561V|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.D561V|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.D595V|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.T561S|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwr.1_Missense_Mutation_p.D606V|DISC1_uc010pws.1_Missense_Mutation_p.T572S|DISC1_uc010pwt.1_3'UTR|DISC1_uc010pwu.1_3'UTR|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.D606V|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.D606V|DISC1_uc010pxb.1_Missense_Mutation_p.D606V|DISC1_uc010pxc.1_Intron|DISC1_uc010pxd.1_Missense_Mutation_p.D251V|DISC1_uc010pxe.1_Missense_Mutation_p.D606V|DISC1_uc009xfr.2_Missense_Mutation_p.D561V|DISC1_uc010pxf.1_Missense_Mutation_p.D606V|DISC1_uc010pxg.1_Intron|DISC1_uc010pxh.1_Missense_Mutation_p.D638V|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.D251V|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.D484V|DISC1_uc010pxn.1_Missense_Mutation_p.D251V|DISC1_uc001hva.2_Missense_Mutation_p.D606V|DISC2_uc001hvd.2_RNA	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	606	Potential.|Necessary and sufficient for interaction with PCNT and localization at the centrosome.|Interaction with TRAF3IP1.|Interaction with ATF4 and ATF5.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				ACGGCTAAAGACCTCACCGAG	0.483													30	31					0	0	0.010818	0	0
PCNXL2	80003	broad.mit.edu	37	1	233225830	233225830	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:233225830C>T	uc001hvl.2	-	23	4288	c.4053G>A	c.(4051-4053)GTG>GTA	p.V1351V	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_Intron	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1351						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CCCAGAATTTCACTGGCCTGA	0.423													9	23					0	0	0.010729	0	0
NID1	4811	broad.mit.edu	37	1	236154255	236154255	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:236154255C>T	uc001hxo.2	-	14	2961	c.2859G>A	c.(2857-2859)AAG>AAA	p.K953K	NID1_uc009xgd.2_Silent_p.K820K|NID1_uc009xgc.2_Silent_p.K39K	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	953					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GGCGCTCAATCTTCCCAGTCT	0.572													7	17					0	0	0.003080	0	0
GPR137B	7107	broad.mit.edu	37	1	236343179	236343179	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:236343179G>A	uc001hxq.2	+	4	779	c.688G>A	c.(688-690)GGC>AGC	p.G230S	GPR137B_uc001hxr.1_Missense_Mutation_p.G12S|GPR137B_uc009xge.2_RNA	NM_003272	NP_003263	O60478	G137B_HUMAN	G protein-coupled receptor 137B	230	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.197)|Prostate(94;0.219)|Acute lymphoblastic leukemia(190;0.226)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			TCTTTTCCAGGGCTCCTCCGT	0.552													15	58					0	0	0.006122	0	0
CHRM3	1131	broad.mit.edu	37	1	240071104	240071104	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:240071104G>A	uc001hyp.2	+	5	1132	c.353G>A	c.(352-354)GGG>GAG	p.G118E		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	118	Helical; Name=2; (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CTGATTATCGGGGTCATTTCA	0.478													18	24					0	0	0.006122	0	0
RGS7	6000	broad.mit.edu	37	1	240975334	240975334	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:240975334C>T	uc001hyv.2	-	14	1296	c.966G>A	c.(964-966)CCG>CCA	p.P322P	RGS7_uc010pyh.1_Silent_p.P296P|RGS7_uc010pyj.1_Silent_p.P238P|RGS7_uc001hyu.2_Silent_p.P322P|RGS7_uc009xgn.1_Silent_p.P269P|RGS7_uc001hyw.2_Silent_p.P322P|RGS7_uc001hyt.2_Silent_p.P154P	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	322					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TCTGCTGGCTCGGTTCTTTGC	0.393													18	38					0	0	0.008871	0	0
TRIM58	25893	broad.mit.edu	37	1	248028016	248028016	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248028016G>A	uc001ido.2	+	3	574	c.526G>A	c.(526-528)GAA>AAA	p.E176K		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	176						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGAGAAAGTGGAAATGCAGAG	0.582													10	23					0	0	0.008291	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285594	248285594	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248285594G>A	uc001idy.1	+	1	157	c.157G>A	c.(157-159)GAC>AAC	p.D53N		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						TATGTCTTATGACTGCTACAT	0.453													63	113					0	0	0.014410	0	0
OR2M3	127062	broad.mit.edu	37	1	248366744	248366744	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248366744C>T	uc010pzg.1	+	1	375	c.375C>T	c.(373-375)GCC>GCT	p.A125A		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCTACACTGCCATTTGCCACC	0.443													26	171					0	0	0.004656	0	0
OR2T1	26696	broad.mit.edu	37	1	248569331	248569331	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248569331C>T	uc010pzm.1	+	1	36	c.36C>T	c.(34-36)TTC>TTT	p.F12F		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTTTTCTTCCCACTTTTAA	0.294													29	39					0	0	0.008361	0	0
OR2T2	401992	broad.mit.edu	37	1	248616389	248616389	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248616389C>T	uc001iek.1	+	1	291	c.291C>T	c.(289-291)GGC>GGT	p.G97G		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTTCCTGGGCTGTGCAGTTC	0.532													52	175					0	0	0.014410	0	0
OR2T34	127068	broad.mit.edu	37	1	248737705	248737705	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:248737705G>A	uc001iep.1	-	1	354	c.354C>T	c.(352-354)TTC>TTT	p.F118F		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGCCAGGAGGAAAACCTCAG	0.562													20	24					0	0	0.004656	0	0
KIAA1217	56243	broad.mit.edu	37	10	24813339	24813339	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:24813339C>T	uc001iru.3	+	13	2947	c.2544C>T	c.(2542-2544)GTC>GTT	p.V848V	KIAA1217_uc001irs.2_Silent_p.V768V|KIAA1217_uc001irt.3_Silent_p.V813V|KIAA1217_uc010qcy.1_Silent_p.V813V|KIAA1217_uc010qcz.1_Silent_p.V813V|KIAA1217_uc001irv.1_Silent_p.V663V|KIAA1217_uc010qda.1_Intron|KIAA1217_uc001irw.2_Silent_p.V531V|KIAA1217_uc001irz.2_Silent_p.V531V|KIAA1217_uc001irx.2_Silent_p.V531V|KIAA1217_uc001iry.2_Silent_p.V531V	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	848					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCGCAGAAGTCCTGAAGAGTC	0.607													31	8					0	0	0.009535	0	0
GPR158	57512	broad.mit.edu	37	10	25701267	25701267	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:25701267C>T	uc001isj.2	+	4	1260	c.1200C>T	c.(1198-1200)CCC>CCT	p.P400P		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	400	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AGGGCTGCCCCTTCTGTGCTG	0.498													82	31					0	0	0.014410	0	0
GPR158	57512	broad.mit.edu	37	10	25886856	25886856	+	Silent	SNP	G	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:25886856G>C	uc001isj.2	+	11	2361	c.2301G>C	c.(2299-2301)CGG>CGC	p.R767R	GPR158_uc001isk.2_Silent_p.R142R	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	767	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CAGTCAGCCGGCAGTGCTCTA	0.572													39	15					0	0	0.004878	0	0
WAC	51322	broad.mit.edu	37	10	28897258	28897258	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:28897258C>T	uc001iuf.2	+	8	1148	c.1063C>T	c.(1063-1065)CCC>TCC	p.P355S	WAC_uc001iud.2_Missense_Mutation_p.P310S|WAC_uc001iue.2_Missense_Mutation_p.P45S|WAC_uc009xlb.2_Missense_Mutation_p.P310S|WAC_uc001iug.2_Missense_Mutation_p.P252S|WAC_uc001iuh.2_Missense_Mutation_p.P310S	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	355					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						GCCAATACCTCCCTTACTTCA	0.468													19	8					0	0	0.006122	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37451602	37451602	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:37451602C>T	uc001iza.1	+	16	1857	c.1758C>T	c.(1756-1758)TTC>TTT	p.F586F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	642						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CATCTGCCTTCGAGGTATTTA	0.328													40	34					0	0	0.013114	0	0
ZNF33A	7581	broad.mit.edu	37	10	38305931	38305931	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:38305931C>T	uc001izh.2	+	3	320	c.142C>T	c.(142-144)CTT>TTT	p.L48F	ZNF33A_uc001izg.2_Missense_Mutation_p.L48F|ZNF33A_uc010qev.1_Missense_Mutation_p.L55F|ZNF33A_uc001izi.1_Missense_Mutation_p.L48F|ZNF33A_uc001izj.2_RNA	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	48	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CTACAGCAACCTTGTCTCAGT	0.438													36	18					0	0	0.010771	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43659461	43659461	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:43659461C>T	uc001jan.2	+	5	1463	c.1128C>T	c.(1126-1128)TTC>TTT	p.F376F		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	376	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						CAGCCGAATTCCTTAACAGCT	0.438													34	12					0	0	0.004289	0	0
GDF10	2662	broad.mit.edu	37	10	48429087	48429087	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:48429087C>T	uc001jfb.2	-	2	1255	c.799G>A	c.(799-801)GAC>AAC	p.D267N	GDF10_uc009xnp.2_Missense_Mutation_p.D266N|GDF10_uc009xnq.1_Missense_Mutation_p.D267N	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	267					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						GGGAAGGGGTCGTATCTCTGC	0.701													6	2					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:48968566A>G	uc001jgc.1	+	3		c.1234A>G								full-length cDNA clone CS0DI009YC01 of Placenta Cot 25-normalized of Homo sapiens (human).																		ACAGGATAACAAACTGGAAAA	0.284													3	8					0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55591165	55591165	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:55591165C>T	uc001jju.1	-	30	4507	c.4112G>A	c.(4111-4113)GGA>GAA	p.G1371E	PCDH15_uc010qhq.1_Missense_Mutation_p.G1376E|PCDH15_uc010qhr.1_Missense_Mutation_p.G1371E|PCDH15_uc010qhs.1_Missense_Mutation_p.G1383E|PCDH15_uc010qht.1_Missense_Mutation_p.G1378E|PCDH15_uc010qhu.1_Missense_Mutation_p.G1371E|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.G1371E|PCDH15_uc010qhw.1_Missense_Mutation_p.G1334E|PCDH15_uc010qhx.1_Missense_Mutation_p.G1300E|PCDH15_uc010qhy.1_Missense_Mutation_p.G1376E|PCDH15_uc010qhz.1_Missense_Mutation_p.G1371E|PCDH15_uc010qia.1_Missense_Mutation_p.G1349E|PCDH15_uc010qib.1_Missense_Mutation_p.G1349E	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1371	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCTGTGTATCCTAGACTTTC	0.483										HNSCC(58;0.16)			44	21					0	0	0.009718	0	0
SUPV3L1	6832	broad.mit.edu	37	10	70940196	70940196	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:70940196C>T	uc001jpe.1	+	1	204	c.149C>T	c.(148-150)TCC>TTC	p.S50F	SUPV3L1_uc010qjd.1_5'UTR	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	50					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						ACCGCCTCCTCCTCTGCCTCC	0.657													34	9					0	0	0.004878	0	0
AGAP11	119385	broad.mit.edu	37	10	88768349	88768350	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:88768349_88768350AC>TT	uc001kee.2	+	12	1544_1545	c.340_341AC>TT	c.(340-342)ACC>TTC	p.T114F	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	114					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TCACGCTGACACCATCGGGAGC	0.52													130	59					0	0	0.004672	0	0
AGAP11	119385	broad.mit.edu	37	10	88769290	88769290	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:88769290G>A	uc001kee.2	+	12	2485	c.1281G>A	c.(1279-1281)AAG>AAA	p.K427K	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	427	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						GGGAAGAGAAGGAACGGTGGA	0.562													59	19					0	0	0.014410	0	0
CYP2C9	1559	broad.mit.edu	37	10	96745846	96745846	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:96745846C>T	uc001kka.3	+	8	1231	c.1206C>T	c.(1204-1206)CCC>CCT	p.P402P	CYP2C9_uc009xut.2_Silent_p.P400P	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	402					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	AAGAATTTCCCAACCCAGAGA	0.373													38	26					0	0	0.006230	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105363294	105363294	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:105363294G>A	uc001kxj.1	-	14	1737	c.1597C>T	c.(1597-1599)CCT>TCT	p.P533S	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.P368S|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.P410S|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.P368S|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.P476S	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	561					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CCGAATGCAGGGATGTCATAC	0.677													14	10					0	0	0.002450	0	0
Unknown	0	broad.mit.edu	37	10	134628402	134628402	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr10:134628402C>A	uc010qux.1	-	43	6312	c.6312G>T	c.(6310-6312)AAG>AAT	p.K2104N		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																		TTCTTCCCTCCTTTTTCACGC	0.572													78	36					3.1376e-36	1.01135e-35	0.014410	1	0
MUC2	4583	broad.mit.edu	37	11	1085744	1085744	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:1085744G>A	uc001lsx.1	+	21	2692	c.2665G>A	c.(2665-2667)GAC>AAC	p.D889N		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	889	VWFD 3.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGGCCCCCAGGACTACTGCGG	0.637													10	13					0	0	0.006214	0	0
MUC2	4583	broad.mit.edu	37	11	1090912	1090912	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:1090912C>T	uc001lsx.1	+	28	3834	c.3807C>T	c.(3805-3807)ACC>ACT	p.T1269T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1269						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ccaccttcaccaccatcaccc	0.398													5	5					0	0	0.000602	0	0
MUC5B	727897	broad.mit.edu	37	11	1265002	1265003	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:1265002_1265003CC>TT	uc009ycr.1	+	48	8932_8933	c.8806_8807CC>TT	c.(8806-8808)CCC>TTC	p.P2936F	MUC5B_uc001ltb.2_Missense_Mutation_p.P2301F	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2298	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GACCCTGCTGCCCAGCAGCCCC	0.683													12	42					0	0	0.004672	0	0
OR52K1	390036	broad.mit.edu	37	11	4510907	4510907	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:4510907C>T	uc001lza.1	+	1	777	c.777C>T	c.(775-777)ATC>ATT	p.I259I		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAGTAGTCATCTCTTCAGTCA	0.527													41	61					0	0	0.014410	0	0
OR51A4	401666	broad.mit.edu	37	11	4967515	4967515	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:4967515G>A	uc010qys.1	-	1	816	c.816C>T	c.(814-816)CTC>CTT	p.L272L		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAACATTAATGAGGGGAGAGA	0.443													31	144					0	0	0.010818	0	0
HBG2	3048	broad.mit.edu	37	11	5275617	5275617	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:5275617C>T	uc001mai.1	-	2	657	c.220G>A	c.(220-222)GAT>AAT	p.D74N	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.D74N	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	74					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTATGGCATCTCCCAAGGAA	0.527													47	103					0	0	0.014410	0	0
OR51Q1	390061	broad.mit.edu	37	11	5444330	5444330	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:5444330G>A	uc010qzd.1	+	1	900	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAACAAGCAGATCCAATGGG	0.423													19	27					0	0	0.007413	0	0
OR52D1	390066	broad.mit.edu	37	11	5510551	5510551	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:5510551G>A	uc010qzg.1	+	1	615	c.615G>A	c.(613-615)GTG>GTA	p.V205V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005163	NP_001005163	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTAACTGTGGCTCTGCTGG	0.498													51	74					0	0	0.014410	0	0
DNHD1	144132	broad.mit.edu	37	11	6520067	6520067	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:6520067G>A	uc001mdw.3	+	3	1186	c.622G>A	c.(622-624)GAG>AAG	p.E208K	DNHD1_uc001mdp.2_Missense_Mutation_p.E208K	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	208					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GGCCCTAGAAGAGGCTGTGTG	0.577													16	72					0	0	0.006122	0	0
NLRP14	338323	broad.mit.edu	37	11	7064042	7064042	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:7064042A>T	uc001mfb.1	+	4	1108	c.785A>T	c.(784-786)GAT>GTT	p.D262V		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	262	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GACAGTTTCGATGAACTGAAC	0.448													7	50					0	0	0.001984	0	0
MICALCL	84953	broad.mit.edu	37	11	12315214	12315214	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:12315214C>T	uc001mkg.1	+	3	527	c.236C>T	c.(235-237)CCC>CTC	p.P79L		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	79	Interaction with MAPK1 (By similarity).				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		AGGGAAATTCCCCTGTATCTG	0.582													24	85					0	0	0.004656	0	0
SOX6	55553	broad.mit.edu	37	11	16119235	16119235	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:16119235C>T	uc001mme.2	-	8	971	c.938_splice	c.e8-1	p.G313_splice	SOX6_uc001mmd.2_Splice_Site_p.G303_splice|SOX6_uc001mmf.2_Splice_Site_p.G300_splice|SOX6_uc001mmg.2_Splice_Site_p.G300_splice	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4						muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						TAGTTATCACCTGTCGGAAAG	0.458													19	26					0	0	0.010504	0	0
MUC15	143662	broad.mit.edu	37	11	26586936	26586936	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:26586936G>A	uc001mqx.2	-	2	736	c.470C>T	c.(469-471)ACC>ATC	p.T157I	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.T184I|MUC15_uc001mqy.2_Missense_Mutation_p.T184I	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	157	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGTTTTCACGGTGTCATTGAC	0.458													15	37					0	0	0.003163	0	0
LGR4	55366	broad.mit.edu	37	11	27390105	27390105	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:27390105G>C	uc001mrj.3	-	18	2650	c.2165C>G	c.(2164-2166)GCC>GGC	p.A722G	LGR4_uc001mrk.3_Missense_Mutation_p.A698G	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	722	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						GTAGATAACGGCCATTAATAA	0.398													38	45					0	0	0.007835	0	0
KIF18A	81930	broad.mit.edu	37	11	28112954	28112954	+	Splice_Site	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:28112954A>T	uc001msc.2	-	4	770	c.588_splice	c.e4+1	p.Q196_splice		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A						blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TTATATACATACCTGGTGTAA	0.388													15	69					0	0	0.006122	0	0
KCNA4	3739	broad.mit.edu	37	11	30032279	30032279	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:30032279C>T	uc001msk.2	-	2	3099	c.1947G>A	c.(1945-1947)GTG>GTA	p.V649V		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	649						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CATCAGTCTCCACAGCCTTTG	0.428													11	54					0	0	0.010729	0	0
Unknown	0	broad.mit.edu	37	11	31086081	31086081	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:31086081C>A	uc009yjk.1	-	8	939	c.870G>T	c.(868-870)ACG>ACT	p.T290T	uc009yjl.1_Silent_p.T218T|DCDC1_uc001msu.1_Silent_p.T461T					RecName: Full=Doublecortin domain-containing protein 5;																		TCAGCTCCCCCGTCTCCTCAA	0.483													5	103					0.00116845	0.00367226	0.001168	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136159	40136159	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:40136159G>T	uc001mxa.1	-	2	3648	c.1684C>A	c.(1684-1686)CCA>ACA	p.P562T	LRRC4C_uc001mxc.1_Missense_Mutation_p.P558T|LRRC4C_uc001mxd.1_Missense_Mutation_p.P558T|LRRC4C_uc001mxb.1_Missense_Mutation_p.P558T	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	562					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTCCTTGTTGGGGCGTGATGG	0.493													19	34					9.7654e-05	0.000309056	0.007413	1	0
ZNF408	79797	broad.mit.edu	37	11	46726247	46726247	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:46726247C>T	uc001nde.1	+	5	1227	c.997C>T	c.(997-999)CCT>TCT	p.P333S	ZNF408_uc010rgw.1_Missense_Mutation_p.P325S	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						GTCTGGCTTCCCTACACTCTC	0.632													22	16					0	0	0.012319	0	0
NUP160	23279	broad.mit.edu	37	11	47827791	47827791	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:47827791G>A	uc001ngm.2	-	20	2605	c.2520C>T	c.(2518-2520)TTC>TTT	p.F840F	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	840					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						TTGGCTGAGAGAAGAGGTGAG	0.353													40	44					0	0	0.005524	0	0
FOLH1	2346	broad.mit.edu	37	11	49196493	49196493	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:49196493C>T	uc001ngy.2	-	9	1317	c.1056G>A	c.(1054-1056)GTG>GTA	p.V352V	FOLH1_uc001ngz.2_Silent_p.V352V|FOLH1_uc009yly.2_Silent_p.V337V|FOLH1_uc009ylz.2_Silent_p.V337V|FOLH1_uc009yma.2_Silent_p.V44V	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	352	NAALADase.|Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAATTCTTGTCACTTCATTGG	0.259													5	24					0	0	0.000602	0	0
OR5D13	390142	broad.mit.edu	37	11	55541419	55541419	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:55541419C>T	uc010ril.1	+	1	506	c.506C>T	c.(505-507)TCG>TTG	p.S169L		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CTTGACTTATCGTTTTGTGAA	0.418													20	41					0	0	0.007413	0	0
OR5W2	390148	broad.mit.edu	37	11	55681218	55681218	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:55681218C>A	uc010rir.1	-	1	841	c.841G>T	c.(841-843)GTG>TTG	p.V281L		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATGGGAACCACAAGGGTGTAA	0.378													11	26					6.40141e-05	0.000202875	0.010729	1	0
OR5R1	219479	broad.mit.edu	37	11	56185123	56185123	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:56185123C>T	uc010rji.1	-	1	586	c.586G>A	c.(586-588)GAA>AAA	p.E196K		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATCAGAATTTCCTTCATGTGT	0.433													26	23					0	0	0.003330	0	0
PRG3	10394	broad.mit.edu	37	11	57147108	57147108	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:57147108G>A	uc001njv.1	-	3	344	c.234C>T	c.(232-234)GCC>GCT	p.A78A		NM_006093	NP_006084	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3 precursor	78					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding				0						CCGACTCCATGGCTTCCTCAT	0.552													19	58					0	0	0.010504	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995786	57995786	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:57995786G>A	uc010rkd.1	-	1	562	c.562C>T	c.(562-564)CCC>TCC	p.P188S		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				CGCAGGACGGGAGGCACATCG	0.622													17	15					0	0	0.012319	0	0
OR5B17	219965	broad.mit.edu	37	11	58125953	58125953	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:58125953A>C	uc010rke.1	-	1	590	c.590T>G	c.(589-591)CTT>CGT	p.L197R		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TATAAGAACAAGAATCAACTC	0.368													3	24					0	0	0.009096	0	0
SLC22A6	9356	broad.mit.edu	37	11	62747339	62747339	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:62747339G>A	uc001nwk.2	-	7	1426	c.1119C>T	c.(1117-1119)ATC>ATT	p.I373I	SLC22A6_uc001nwl.2_Silent_p.I373I|SLC22A6_uc001nwj.2_Silent_p.I373I|SLC22A6_uc001nwm.2_Silent_p.I373I	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	373	Helical; (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						CAGCACCAAAGATCACCTGGA	0.572													12	30					0	0	0.010729	0	0
ATG2A	23130	broad.mit.edu	37	11	64677197	64677197	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:64677197G>A	uc001obx.2	-	14	2178	c.2063C>T	c.(2062-2064)CCC>CTC	p.P688L		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	688							protein binding			ovary(1)|central_nervous_system(1)	2						GGGGACTGGGGGACCAGGCCC	0.667													5	23					0	0	0.001168	0	0
ZFPL1	7542	broad.mit.edu	37	11	64855563	64855563	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:64855563C>T	uc001ocq.1	+	8	1075	c.910C>T	c.(910-912)CAC>TAC	p.H304Y		NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	304	Lumenal (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						CATGAACCCTCACATCCGCGT	0.657													15	50					0	0	0.004007	0	0
MTL5	9633	broad.mit.edu	37	11	68478403	68478403	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:68478403C>T	uc001ooc.2	-	9	1413	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	425					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TGGCTGCCTTCCAAACCTCCA	0.418													19	19					0	0	0.008871	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293629	71293629	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:71293629G>A	uc001oqu.2	-	1	293	c.255C>T	c.(253-255)TCC>TCT	p.S85S		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	85	6 X 4 AA repeats of C-C-X-P.					keratin filament					0						TACAGCAGTTGGACTGGGAGC	0.358													10	43					0	0	0.006214	0	0
CNTN5	53942	broad.mit.edu	37	11	100170080	100170080	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:100170080G>A	uc001pga.2	+	20	2911	c.2572G>A	c.(2572-2574)GGA>AGA	p.G858R	CNTN5_uc001pfz.2_Missense_Mutation_p.G858R|CNTN5_uc001pgb.2_Missense_Mutation_p.G784R|CNTN5_uc010ruk.1_Missense_Mutation_p.G129R	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	858	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAACAATAAAGGAGATGGGCC	0.348													14	51					0	0	0.004007	0	0
KIAA1377	57562	broad.mit.edu	37	11	101833006	101833006	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:101833006A>G	uc001pgm.2	+	6	1510	c.1240A>G	c.(1240-1242)ACA>GCA	p.T414A	KIAA1377_uc001pgn.2_Missense_Mutation_p.T370A|KIAA1377_uc010run.1_Missense_Mutation_p.T215A|KIAA1377_uc009yxa.1_Missense_Mutation_p.T215A	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	414							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TGAGAGCCCAACATTTAAATT	0.373													18	24					0	0	0.007413	0	0
GRIA4	2893	broad.mit.edu	37	11	105623843	105623843	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:105623843C>T	uc001pix.2	+	4	830	c.384C>T	c.(382-384)AGC>AGT	p.S128S	GRIA4_uc001piu.1_Silent_p.S128S|GRIA4_uc001piw.2_Silent_p.S128S|GRIA4_uc001piv.2_Silent_p.S128S|GRIA4_uc009yxk.1_Silent_p.S128S	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	128	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AGGGGGAGAGCCAGTTTGTGC	0.473													20	17					0	0	0.012319	0	0
DRD2	1813	broad.mit.edu	37	11	113295249	113295249	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:113295249G>A	uc001pnz.2	-	1	446	c.125C>T	c.(124-126)ACC>ATC	p.T42I	DRD2_uc010rwv.1_Missense_Mutation_p.T42I|DRD2_uc001poa.3_Missense_Mutation_p.T42I|DRD2_uc001pob.3_Missense_Mutation_p.T42I|DRD2_uc009yyr.1_Missense_Mutation_p.T42I	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	42	Helical; Name=1; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GATGAGCAGGGTGAGCAGTGT	0.587													26	46					0	0	0.004656	0	0
BUD13	84811	broad.mit.edu	37	11	116633303	116633303	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:116633303G>A	uc001ppn.2	-	4	1036	c.1002C>T	c.(1000-1002)TCC>TCT	p.S334S	BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Silent_p.S334S	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	334										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTCCAAAATGGGATTTTGCTT	0.448													82	262					0	0	0.014410	0	0
CCDC153	283152	broad.mit.edu	37	11	119063891	119063891	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:119063891C>T	uc010rze.1	-	5	407	c.319G>A	c.(319-321)GAA>AAA	p.E107K		NM_001145018	NP_001138490	Q494R4	CC153_HUMAN	coiled-coil domain containing 153	107	Potential.										0						TTGACTTCTTCCTCCAGCTGC	0.617													23	24					0	0	0.003330	0	0
SORL1	6653	broad.mit.edu	37	11	121393401	121393401	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:121393401T>C	uc001pxx.2	+	10	1591	c.1511T>C	c.(1510-1512)ATC>ACC	p.I504T		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	504	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCAGGCCTCATCATCGCCACT	0.582													17	71					0	0	0.004990	0	0
C11orf63	79864	broad.mit.edu	37	11	122774974	122774974	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:122774974T>G	uc001pym.2	+	3	983	c.686T>G	c.(685-687)GTG>GGG	p.V229G	C11orf63_uc001pyl.1_Missense_Mutation_p.V229G	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	229										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TCTCCGTACGTGAAGAGCTCA	0.512													16	57					0	0	0.004990	0	0
OR6X1	390260	broad.mit.edu	37	11	123624405	123624405	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:123624405C>T	uc010rzy.1	-	1	822	c.822G>A	c.(820-822)GTG>GTA	p.V274V		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TAGTATTTAGCACAGACACCA	0.458													37	40					0	0	0.003755	0	0
OR10G8	219869	broad.mit.edu	37	11	123901194	123901194	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:123901194C>T	uc001pzp.1	+	1	865	c.865C>T	c.(865-867)CTG>TTG	p.L289L		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGTGTACACCCTGAGGAACAA	0.413													15	46					0	0	0.003163	0	0
ROBO4	54538	broad.mit.edu	37	11	124756364	124756364	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:124756364G>T	uc001qbg.2	-	16	2930	c.2790C>A	c.(2788-2790)TTC>TTA	p.F930L	ROBO4_uc010sas.1_Missense_Mutation_p.F785L|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.F488L	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	930					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACATACCTATGAAGACGCAGT	0.478													19	31					1.01871e-10	3.2467e-10	0.008871	1	0
CHEK1	1111	broad.mit.edu	37	11	125503111	125503111	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:125503111C>T	uc009zbo.2	+	6	1370	c.478C>T	c.(478-480)CGT>TGT	p.R160C	CHEK1_uc010sbh.1_Missense_Mutation_p.R176C|CHEK1_uc010sbi.1_Missense_Mutation_p.R160C|CHEK1_uc001qcf.3_Missense_Mutation_p.R160C|CHEK1_uc009zbp.2_Missense_Mutation_p.R160C|CHEK1_uc001qcg.3_Missense_Mutation_p.R160C|CHEK1_uc009zbq.2_Missense_Mutation_p.R160C|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	160	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity	p.R160H(1)		central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		GTATAATAATCGTGAGCGTTT	0.358								Other_conserved_DNA_damage_response_genes					18	54					0	0	0.010504	0	0
TIRAP	114609	broad.mit.edu	37	11	126162942	126162942	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:126162942T>C	uc001qdm.1	+	5	1090	c.638T>C	c.(637-639)GTC>GCC	p.V213A	TIRAP_uc001qdl.1_Missense_Mutation_p.V213A|TIRAP_uc009zcb.1_Missense_Mutation_p.V213A|TIRAP_uc001qdn.1_Missense_Mutation_p.V213A|TIRAP_uc001qdo.1_Missense_Mutation_p.V213A	NM_001039661	NP_001034750	P58753	TIRAP_HUMAN	Toll-interleukin 1 receptor domain-containing	213	TIR.				3'-UTR-mediated mRNA stabilization|cellular response to bacterial lipopeptide|cellular response to lipoteichoic acid|defense response to Gram-positive bacterium|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|myeloid cell differentiation|negative regulation of growth of symbiont in host|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-12 production|positive regulation of interleukin-15 production|positive regulation of interleukin-6 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of JNK cascade|positive regulation of neutrophil chemotaxis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein homodimerization activity|positive regulation of toll-like receptor 2 signaling pathway|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|response to lipopolysaccharide|TIRAP-dependent toll-like receptor 4 signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway	endocytic vesicle|intrinsic to membrane|ruffle membrane	phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|protein heterodimerization activity|protein homodimerization activity|protein kinase C delta binding|Toll-like receptor 2 binding|Toll-like receptor 4 binding|transmembrane receptor activity			ovary(1)	1	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0739)		AAAGAAGCTGTCATGCGTTGT	0.498													14	8					0	0	0.003163	0	0
JAM3	83700	broad.mit.edu	37	11	134009758	134009758	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:134009758G>A	uc001qhb.1	+	2	248	c.224G>A	c.(223-225)GGG>GAG	p.G75E	JAM3_uc009zcz.1_Missense_Mutation_p.G75E	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	30					angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TGCCTGATAGGGGCTGTAAAT	0.453											OREG0021547	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	21					0	0	0.013537	0	0
GALNT8	26290	broad.mit.edu	37	12	4848473	4848473	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:4848473G>A	uc001qne.1	+	3	746	c.654G>A	c.(652-654)TTG>TTA	p.L218L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	218	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						AAATCATCTTGGTGGATGATT	0.418													12	44					0	0	0.013537	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6427490	6427490	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:6427490G>A	uc001qnr.2	+	11	1327	c.1179G>A	c.(1177-1179)CTG>CTA	p.L393L	PLEKHG6_uc001qns.2_Silent_p.L393L|PLEKHG6_uc010sew.1_Silent_p.L393L|PLEKHG6_uc010sex.1_Silent_p.L361L	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	393					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						TCTCCACCCTGGACCTGACGT	0.652													11	15					0	0	0.013537	0	0
CD163L1	283316	broad.mit.edu	37	12	7510023	7510023	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:7510023G>A	uc001qsy.2	-	19	4365	c.4339C>T	c.(4339-4341)CCT>TCT	p.P1447S	CD163L1_uc010sge.1_Missense_Mutation_p.P1457S	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1447	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						TCAGAGGCAGGAAGAACTCCC	0.413													18	53					0	0	0.012319	0	0
CD163	9332	broad.mit.edu	37	12	7635291	7635291	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:7635291G>A	uc001qsz.3	-	14	3323	c.3195C>T	c.(3193-3195)TTC>TTT	p.F1065F	CD163_uc001qta.3_Silent_p.F1065F|CD163_uc009zfw.2_Silent_p.F1098F	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1065	Helical; (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						ATAATGCGACGAAAATGGCCA	0.423													53	58					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	12	8048183	8048183	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:8048183G>A	uc001qtp.1	+	2	171	c.91G>A	c.(91-93)GAA>AAA	p.E31K						RecName: Full=Putative homeobox protein NANOG2;																		CACAAAAAAGGAAGACAAGGT	0.473													12	35					0	0	0.010729	0	0
KLRC3	3823	broad.mit.edu	37	12	10571009	10571009	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:10571009C>T	uc001qyf.2	-	4	465	c.420G>A	c.(418-420)GAG>GAA	p.E140E	KLRC3_uc001qyh.2_Silent_p.E140E|KLRC3_uc001qyi.1_Silent_p.E140E|KLRC3_uc010shc.1_Missense_Mutation_p.R124K|KLRC3_uc010shd.1_3'UTR	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	140	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						CCTGCAAACTCTCTTCCCAAG	0.353													23	89					0	0	0.006320	0	0
ATF7IP	55729	broad.mit.edu	37	12	14578322	14578322	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:14578322C>T	uc001rbw.2	+	2	1631	c.1473C>T	c.(1471-1473)GCC>GCT	p.A491A	ATF7IP_uc010shs.1_Silent_p.A491A|ATF7IP_uc001rbu.2_Silent_p.A491A|ATF7IP_uc001rbv.1_Silent_p.A491A|ATF7IP_uc001rbx.2_Silent_p.A491A|ATF7IP_uc010sht.1_Silent_p.A491A|ATF7IP_uc001rby.3_Silent_p.A491A|ATF7IP_uc001rbz.1_Silent_p.A491A|ATF7IP_uc001rca.2_Silent_p.A491A|ATF7IP_uc001rcb.2_Silent_p.A102A	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	491	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						CAAAAGAAGCCTTTCTGGTCC	0.383													10	33					0	0	0.006214	0	0
KCNJ8	3764	broad.mit.edu	37	12	21918681	21918682	+	Missense_Mutation	DNP	TC	GT	GT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:21918681_21918682TC>GT	uc001rff.2	-	3	1588_1589	c.1250_1251GA>AC	c.(1249-1251)GGA>GAC	p.G417D		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	417	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	TGTTTTGATTTCCTTCTGGAGT	0.426													37	46					0	0	0.004672	0	0
SSPN	8082	broad.mit.edu	37	12	26383984	26383984	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:26383984C>T	uc001rhe.2	+	3	807	c.707C>T	c.(706-708)TCC>TTC	p.S236F	SSPN_uc001rhd.2_Missense_Mutation_p.S133F|SSPN_uc009zjf.2_Intron|SSPN_uc001rhf.3_Intron	NM_005086	NP_005077	Q14714	SSPN_HUMAN	sarcospan isoform 1	236	Cytoplasmic (Potential).				cell adhesion|muscle contraction	cell junction|dystrophin-associated glycoprotein complex|integral to plasma membrane|postsynaptic membrane|sarcolemma|transport vesicle					0	Colorectal(261;0.0847)					CTCACGGCTTCCGAAGGCCCC	0.453													7	19					0	0	0.003080	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967660	41967660	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:41967660C>T	uc010skn.1	+	10	2550	c.2482C>T	c.(2482-2484)CAT>TAT	p.H828Y	PDZRN4_uc001rmq.3_Missense_Mutation_p.H769Y|PDZRN4_uc009zjz.2_Missense_Mutation_p.H767Y|PDZRN4_uc001rmr.2_Missense_Mutation_p.H654Y	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	1027							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CACGAGAGTCCATAATGCCTT	0.443													5	36					0	0	0.000602	0	0
TMEM117	84216	broad.mit.edu	37	12	44781983	44781983	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:44781983C>T	uc001rod.2	+	8	1139	c.1073C>T	c.(1072-1074)TCC>TTC	p.S358F	TMEM117_uc001roe.2_Missense_Mutation_p.S254F|TMEM117_uc009zkc.2_3'UTR	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	358						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		ACCAAGCTATCCTGGGAATGG	0.413													36	34					0	0	0.003755	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45457959	45457959	+	RNA	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:45457959G>A	uc001rol.2	-	1		c.1236C>T				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						TTCTCTTTCAGCTTTTACTGT	0.438													9	18					0	0	0.010729	0	0
SLC38A4	55089	broad.mit.edu	37	12	47170762	47170762	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:47170762C>T	uc001rpi.2	-	13	1498	c.1099G>A	c.(1099-1101)GTG>ATG	p.V367M	SLC38A4_uc001rpj.2_Missense_Mutation_p.V367M	NM_018018	NP_060488	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	367	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)					ATATTTGACACCGTTTGCATT	0.383													12	50					0	0	0.010729	0	0
TROAP	10024	broad.mit.edu	37	12	49724243	49724243	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:49724243C>G	uc001rtx.3	+	13	1782	c.1615C>G	c.(1615-1617)CAG>GAG	p.Q539E	TROAP_uc009zlh.2_Missense_Mutation_p.Q539E|TROAP_uc001rty.2_Missense_Mutation_p.Q247E	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	539	Cys-rich.|4 X 33 AA approximate tandem repeats.|1.				cell adhesion	cytoplasm				ovary(1)	1						GCCCTCCCTCCAGGAACAGCT	0.632													26	22					0	0	0.004656	0	0
LIMA1	51474	broad.mit.edu	37	12	50615941	50615941	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:50615941G>A	uc001rwj.3	-	4	667	c.493C>T	c.(493-495)CTA>TTA	p.L165L	LIMA1_uc001rwh.3_Silent_p.L5L|LIMA1_uc001rwi.3_Silent_p.L5L|LIMA1_uc001rwk.3_Silent_p.L165L|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	165					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GATTCTCCTAGACAATTTTCC	0.418													18	64					0	0	0.004990	0	0
KRT5	3852	broad.mit.edu	37	12	52913965	52913965	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:52913965C>G	uc001san.2	-	1	279	c.116G>C	c.(115-117)GGG>GCG	p.G39A	KRT5_uc009zmh.2_Missense_Mutation_p.G39A	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	39	Head.|Gly-rich.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACCGCCACCCCCGGACCGGGA	0.677													3	25					0	0	0.004672	0	0
KRT74	121391	broad.mit.edu	37	12	52963665	52963665	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:52963665T>C	uc001sap.1	-	6	1160	c.1112A>G	c.(1111-1113)GAG>GGG	p.E371G		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	371	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		ATTCCCGATCTCACACCGGAT	0.607													17	23					0	0	0.007413	0	0
INHBC	3626	broad.mit.edu	37	12	57843234	57843234	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:57843234C>T	uc001snv.1	+	2	615	c.488C>T	c.(487-489)ACC>ATC	p.T163I		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	163					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						ACCAACCTCACCTTGGCTACT	0.567													39	45					0	0	0.007835	0	0
LGR5	8549	broad.mit.edu	37	12	71898435	71898435	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:71898435C>T	uc001swl.2	+	2	302	c.254C>T	c.(253-255)CCC>CTC	p.P85L	LGR5_uc001swm.2_Missense_Mutation_p.P85L|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	85	LRR 1.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						CTCCCGAATCCCCTGCCCAGT	0.507													34	100					0	0	0.004289	0	0
GLIPR1	11010	broad.mit.edu	37	12	75874745	75874745	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:75874745G>A	uc001sxs.2	+	1	233	c.85G>A	c.(85-87)GAA>AAA	p.E29K	GLIPR1_uc009zsb.1_Missense_Mutation_p.E29K	NM_006851	NP_006842	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1 precursor	29					cellular lipid metabolic process	extracellular region|integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3						GCCAGATATCGAAAATGAAGA	0.403													13	31					0	0	0.013537	0	0
NAV3	89795	broad.mit.edu	37	12	78513028	78513028	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:78513028G>C	uc001syp.2	+	15	3225	c.3052G>C	c.(3052-3054)GAT>CAT	p.D1018H	NAV3_uc001syo.2_Missense_Mutation_p.D1018H|NAV3_uc010sub.1_Missense_Mutation_p.D518H|NAV3_uc009zsf.2_Missense_Mutation_p.D26H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1018						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GAAAACCGATGATGCCAAAGC	0.388										HNSCC(70;0.22)			12	78					0	0	0.003163	0	0
C12orf50	160419	broad.mit.edu	37	12	88381713	88381713	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:88381713G>A	uc001tam.1	-	9	899	c.731C>T	c.(730-732)TCC>TTC	p.S244F	C12orf50_uc001tan.2_Intron	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	244										skin(2)|ovary(1)	3						GGTAGTTAGGGAATGCTTTGG	0.343													19	30					0	0	0.002780	0	0
NUDT4	11163	broad.mit.edu	37	12	93793087	93793087	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:93793087C>A	uc001tcm.2	+	5	873	c.475C>A	c.(475-477)CTT>ATT	p.L159I	NUDT4_uc010sup.1_Missense_Mutation_p.L159I|NUDT4_uc001tcn.2_Missense_Mutation_p.L107I|NUDT4_uc010suq.1_Missense_Mutation_p.L108I|NUDT4_uc001tco.2_Missense_Mutation_p.L107I	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	159					calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						AGTCCCTTCCCTTCCGGATAA	0.473													19	151					4.35082e-09	1.38468e-08	0.010504	1	0
ANKS1B	56899	broad.mit.edu	37	12	99223026	99223026	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:99223026C>T	uc001tge.1	-	19	3409	c.2992G>A	c.(2992-2994)GAT>AAT	p.D998N	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc001tgk.2_Missense_Mutation_p.D295N|ANKS1B_uc010svd.1_Missense_Mutation_p.D4N|ANKS1B_uc001tgd.1_Intron|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_Missense_Mutation_p.D4N|ANKS1B_uc001tgh.3_Missense_Mutation_p.D4N|ANKS1B_uc001tgi.2_Missense_Mutation_p.D224N|ANKS1B_uc009ztr.2_Intron|ANKS1B_uc001tgj.2_Intron|ANKS1B_uc009ztp.2_Missense_Mutation_p.D4N|ANKS1B_uc010svf.1_Missense_Mutation_p.D4N|ANKS1B_uc001tgg.3_Intron|ANKS1B_uc010svg.1_Intron|ANKS1B_uc009zts.1_Missense_Mutation_p.D224N	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	998						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CTCCTTGCATCGCCCTGCATG	0.463													46	73					0	0	0.014410	0	0
RFX4	5992	broad.mit.edu	37	12	107080830	107080830	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:107080830C>T	uc001tlr.2	+	6	612	c.546C>T	c.(544-546)CCC>CCT	p.P182P	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Silent_p.P191P|RFX4_uc001tlt.2_Silent_p.P191P|RFX4_uc001tlv.2_Silent_p.P88P|uc001tlu.3_5'Flank	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	182					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						CAGAATTTCCCAATGTCAAAG	0.468													38	47					0	0	0.008740	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686389	108686389	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:108686389G>A	uc009zuw.2	-	3	542	c.351C>T	c.(349-351)TTC>TTT	p.F117F	CMKLR1_uc001tmw.2_Silent_p.F117F|CMKLR1_uc001tmv.2_Silent_p.F115F|CMKLR1_uc009zuv.2_Silent_p.F117F	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	117	Helical; Name=3; (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GGATGAGAAGGAAGTTGCTGA	0.532													6	34					0	0	0.001168	0	0
OAS3	4940	broad.mit.edu	37	12	113400697	113400697	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:113400697C>T	uc001tug.2	+	9	2161	c.2074C>T	c.(2074-2076)CGA>TGA	p.R692*		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	692	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						TGGCCAGCTTCGAAAACCCAG	0.567													31	108					0	0	0.004289	0	0
NOS1	4842	broad.mit.edu	37	12	117665423	117665423	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:117665423C>T	uc001twm.1	-	23	4115	c.3429G>A	c.(3427-3429)TGG>TGA	p.W1143*		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1143	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGCCCCATTTCCATTCCTCGT	0.592													17	17					0	0	0.007413	0	0
TMEM120B	144404	broad.mit.edu	37	12	122209433	122209433	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:122209433C>T	uc001ubc.3	+	8	801	c.657C>T	c.(655-657)TTC>TTT	p.F219F	TMEM120B_uc009zxh.2_Silent_p.F219F	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	219						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		GCAACCAGTTCTTAGCATTTT	0.483													28	26					0	0	0.008361	0	0
HPD	3242	broad.mit.edu	37	12	122295687	122295688	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:122295687_122295688GG>AA	uc001ubj.2	-	3	108_109	c.68_69CC>TT	c.(67-69)ACC>ATT	p.T23I	HPD_uc001ubk.2_5'UTR	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	23					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	CAACCCAGAAGGTCACAGAGTG	0.599													9	13					0	0	0.004672	0	0
GPR109A	338442	broad.mit.edu	37	12	123187700	123187700	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:123187700C>T	uc001ucx.1	-	1	205	c.131G>A	c.(130-132)GGC>GAC	p.G44D	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	44	Helical; Name=1; (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	AAGGCCATTGCCCAGAAGCCC	0.507													13	12					0	0	0.002450	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834043	125834043	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr12:125834043C>T	uc001uhe.1	+	2	106	c.98C>T	c.(97-99)TCG>TTG	p.S33L		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	33	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AAGTTTTCCTCGCTCCCTGCT	0.463													32	80					0	0	0.003755	0	0
SACS	26278	broad.mit.edu	37	13	23928011	23928011	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:23928011G>A	uc001uon.2	-	9	2687	c.2098C>T	c.(2098-2100)CTT>TTT	p.L700F	SACS_uc001uoo.2_Missense_Mutation_p.L553F|SACS_uc001uop.1_Missense_Mutation_p.L487F|SACS_uc001uoq.1_Missense_Mutation_p.L553F	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	700					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTTGGGAAAAGGGACCTGAAA	0.373													22	30					0	0	0.003330	0	0
CENPJ	55835	broad.mit.edu	37	13	25457366	25457366	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:25457366C>T	uc001upt.3	-	17	4219	c.3966G>A	c.(3964-3966)CGG>CGA	p.R1322R	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	1322					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TAACTCTTATCCGACCGGATC	0.428													53	57					0	0	0.014410	0	0
DNAJC15	29103	broad.mit.edu	37	13	43652761	43652761	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:43652761A>G	uc001uyy.2	+	4	649	c.248A>G	c.(247-249)TAC>TGC	p.Y83C		NM_013238	NP_037370	Q9Y5T4	DJC15_HUMAN	DNAJ domain-containing	83						integral to membrane	heat shock protein binding				0		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		TTTTCATCCTACTATAAAGGA	0.408													6	19					0	0	0.001168	0	0
SCEL	8796	broad.mit.edu	37	13	78187050	78187050	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:78187050C>T	uc001vki.2	+	23	1532	c.1362C>T	c.(1360-1362)ATC>ATT	p.I454I	SCEL_uc001vkj.2_Silent_p.I434I|SCEL_uc010thx.1_Silent_p.I412I	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	454	16 X approximate tandem repeats.|11.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AAAATCTTATCAAAGTGATCC	0.264													21	36					0	0	0.005443	0	0
SPRY2	10253	broad.mit.edu	37	13	80911390	80911390	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:80911390G>A	uc001vli.2	-	2	1429	c.451C>T	c.(451-453)CGG>TGG	p.R151W	SPRY2_uc001vlj.2_Missense_Mutation_p.R151W	NM_005842	NP_005833	O43597	SPY2_HUMAN	sprouty 2	151					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of gene expression|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein kinase B signaling cascade	cytosol|microtubule|ruffle membrane	protein serine/threonine kinase activator activity			ovary(1)|lung(1)	2	Medulloblastoma(90;0.18)	Acute lymphoblastic leukemia(28;0.218)|Breast(118;0.244)		GBM - Glioblastoma multiforme(99;0.0318)		GGTTGCACCCGGATTATGCCA	0.562													4	31					0	0	0.000602	0	0
CLDN10	9071	broad.mit.edu	37	13	96230203	96230203	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:96230203C>T	uc001vmh.2	+	5	683	c.622C>T	c.(622-624)CAT>TAT	p.H208Y	CLDN10_uc001vmg.2_Missense_Mutation_p.H206Y|CLDN10_uc010tii.1_Missense_Mutation_p.H187Y|DZIP1_uc010afn.2_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	208	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			GACAAAGTATCATGGTGGAGA	0.388													18	27					0	0	0.010504	0	0
MYO16	23026	broad.mit.edu	37	13	109817396	109817396	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:109817396C>T	uc001vqt.1	+	33	5372	c.5246C>T	c.(5245-5247)TCC>TTC	p.S1749F	MYO16_uc010agk.1_Missense_Mutation_p.S1771F	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1749					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AATGGAAATTCCATCTCAAAT	0.323													25	17					0	0	0.005443	0	0
COL4A2	1284	broad.mit.edu	37	13	111088659	111088659	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:111088659C>T	uc001vqx.2	+	13	1059	c.770C>T	c.(769-771)ACC>ATC	p.T257I		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	257	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCATCAGACACCCTCCACCCC	0.458													17	14					0	0	0.012319	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215876	20215876	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:20215876G>A	uc010tkt.1	+	1	290	c.290G>A	c.(289-291)GGA>GAA	p.G97E		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTTTTCAGGATGCCTGGCC	0.473													5	35					0	0	0.000602	0	0
OR4M1	441670	broad.mit.edu	37	14	20248826	20248826	+	Silent	SNP	C	T	T	rs138166254		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:20248826C>T	uc010tku.1	+	1	345	c.345C>T	c.(343-345)CTC>CTT	p.L115L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTTCTTGCTCACAGTGATGG	0.488													23	151					0	0	0.014323	0	0
OR4K2	390431	broad.mit.edu	37	14	20345228	20345228	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:20345228G>A	uc001vwh.1	+	1	802	c.802G>A	c.(802-804)GAC>AAC	p.D268N		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTTCTCACAGACAAGATTCT	0.398													15	70					0	0	0.003163	0	0
OR4K1	79544	broad.mit.edu	37	14	20404103	20404103	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:20404103C>T	uc001vwj.1	+	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AAGACTATCTCCTTTGAGGGT	0.403													20	118					0	0	0.012319	0	0
OR4N5	390437	broad.mit.edu	37	14	20612380	20612380	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:20612380T>C	uc010tla.1	+	1	486	c.486T>C	c.(484-486)CTT>CTC	p.L162L		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		AAGTAGCCCTTATCCTGCACT	0.478													23	52					0	0	0.014323	0	0
OR6S1	341799	broad.mit.edu	37	14	21109567	21109567	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:21109567G>A	uc001vxv.1	-	1	284	c.284C>T	c.(283-285)TCC>TTC	p.S95F		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		TGCAGCAAAGGAAATAGTGTG	0.468													18	33					0	0	0.014323	0	0
OR10G2	26534	broad.mit.edu	37	14	22102909	22102909	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:22102909G>A	uc010tmc.1	-	1	90	c.90C>T	c.(88-90)CTC>CTT	p.L30L		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CCAGGAAGAGGAGGCTTCTTA	0.502													28	42					0	0	0.008361	0	0
CDH24	64403	broad.mit.edu	37	14	23523812	23523812	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:23523812G>A	uc001wil.2	-	5	947	c.687C>T	c.(685-687)GCC>GCT	p.A229A	CDH24_uc010akf.2_Silent_p.A229A|CDH24_uc001win.3_Silent_p.A229A	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	229	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCATGTCCTTGGCCTGGATCA	0.602											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	26					0	0	0.004482	0	0
NYNRIN	57523	broad.mit.edu	37	14	24877292	24877293	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:24877292_24877293GG>AA	uc001wpf.3	+	3	734_735	c.416_417GG>AA	c.(415-417)GGG>GAA	p.G139E		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	139					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GAGCTGGTGGGGCGACTGCGCT	0.683													6	9					0	0	0.004672	0	0
HECTD1	25831	broad.mit.edu	37	14	31598181	31598181	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:31598181G>A	uc001wrc.1	-	25	4885	c.4396C>T	c.(4396-4398)CCT>TCT	p.P1466S	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.P934S	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1466	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GAACTATCAGGGCCTAACTTC	0.443													14	32					0	0	0.004007	0	0
C14orf126	112487	broad.mit.edu	37	14	31926593	31926593	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:31926593C>T	uc001wrj.2	-	1	88	c.7G>A	c.(7-9)GAG>AAG	p.E3K	HEATR5A_uc010tpk.1_5'UTR	NM_080664	NP_542395	Q96FN9	DTD2_HUMAN	hypothetical protein LOC112487	3					D-amino acid catabolic process	cytoplasm	hydrolase activity, acting on ester bonds				0	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0113)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00888)		CGGCTACCCTCAGCCATGGCT	0.706													4	4					0	0	0.009096	0	0
NPAS3	64067	broad.mit.edu	37	14	34266709	34266709	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:34266709C>G	uc001wru.2	+	11	1412	c.1348C>G	c.(1348-1350)CAT>GAT	p.H450D	NPAS3_uc001wrs.2_Missense_Mutation_p.H437D|NPAS3_uc001wrt.2_Missense_Mutation_p.H418D|NPAS3_uc001wrv.2_Missense_Mutation_p.H420D	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ACAGCTCCCCCATCTGCCGGA	0.507													13	40					0	0	0.002450	0	0
SLC35F4	341880	broad.mit.edu	37	14	58048095	58048095	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:58048095C>T	uc001xdb.1	-	4	752	c.752G>A	c.(751-753)AGA>AAA	p.R251K	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.R92K	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GGGAGCAGTTCTTTTAAGAAA	0.413													5	9					0	0	0.003080	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68221874	68221874	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:68221874T>C	uc001xka.2	-	37	7019	c.6880A>G	c.(6880-6882)AAG>GAG	p.K2294E	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkb.2_Missense_Mutation_p.K140E	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2294					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCCTTGGCCTTAAGTAGCCAT	0.478													15	41					0	0	0.003163	0	0
YLPM1	56252	broad.mit.edu	37	14	75302090	75302090	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:75302090C>T	uc001xqj.3	+	20	6541	c.6417C>T	c.(6415-6417)GCC>GCT	p.A2139A	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1944					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CTGAAAAAGCCCTCAATCGAA	0.413													16	36					0	0	0.004990	0	0
NRXN3	9369	broad.mit.edu	37	14	79432697	79432697	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:79432697C>T	uc001xun.2	+	9	2097	c.1606C>T	c.(1606-1608)CTC>TTC	p.L536F	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.L661F	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	909	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity	p.L536I(1)		ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGCTTCATTCTCTTCAATAG	0.473													23	40					0	0	0.014323	0	0
DIO2	1734	broad.mit.edu	37	14	80669401	80669401	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:80669401G>A	uc010tvq.1	-	4	855	c.453C>T	c.(451-453)TCC>TCT	p.S151S	DIO2_uc010tvp.1_Silent_p.S187S|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_3'UTR|DIO2_uc010tvr.1_Silent_p.S151S|DIO2_uc010asy.2_3'UTR	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	151					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		CAGCCACTGAGGAGAACTCTT	0.562											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	11					0	0	0.000602	0	0
C14orf145	145508	broad.mit.edu	37	14	81251619	81251619	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:81251619G>A	uc001xux.2	-	14	2002	c.1831C>T	c.(1831-1833)CAC>TAC	p.H611Y	C14orf145_uc010asz.1_RNA	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	611	Potential.					centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		TCCTCCAAGTGAGCTTTCTCA	0.453													29	58					0	0	0.007291	0	0
PTPN21	11099	broad.mit.edu	37	14	88945372	88945372	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:88945372G>A	uc001xwv.3	-	13	2734	c.2403C>T	c.(2401-2403)CTC>CTT	p.L801L	PTPN21_uc010twc.1_Silent_p.L597L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	801						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						CTGACGTGGTGAGGTCGGACT	0.647													10	16					0	0	0.008291	0	0
PPP4R4	57718	broad.mit.edu	37	14	94700961	94700961	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:94700961G>A	uc001ycs.1	+	7	840	c.686G>A	c.(685-687)CGA>CAA	p.R229Q		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	229	HEAT 1.					cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TATGAAGTTCGATCTTGTATG	0.388													9	16					0	0	0.010729	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033518	95033518	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:95033518G>A	uc001ydk.2	+	3	927	c.861G>A	c.(859-861)AGG>AGA	p.R287R	SERPINA4_uc010avd.2_Silent_p.R324R|SERPINA4_uc001ydl.2_Silent_p.R287R	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	287					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		GCAAAATGAGGGAGATTGAAG	0.468													13	15					0	0	0.013537	0	0
MIR543	100126335	broad.mit.edu	37	14	101498395	101498395	+	RNA	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:101498395C>T	hsa-mir-543|MI0005565	+			c.72C>T			MIR495_hsa-mir-495|MI0003135_5'Flank																	0						ACTTCTTTTTCAGTATCCTAT	0.502													8	15					0	0	0.008291	0	0
JAG2	3714	broad.mit.edu	37	14	105609037	105609037	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:105609037C>T	uc001yqg.2	-	26	4116	c.3712G>A	c.(3712-3714)GAG>AAG	p.E1238K	JAG2_uc010axf.2_Silent_p.R61R|JAG2_uc001yqf.2_Missense_Mutation_p.E642K|JAG2_uc001yqh.2_Missense_Mutation_p.E1200K	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	1238	Cytoplasmic (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CGCCCCTACTCCTTGCCGGCG	0.706													3	4					0	0	0.009096	0	0
BRF1	2972	broad.mit.edu	37	14	105684023	105684023	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:105684023G>C	uc001yqp.2	-	15	1993	c.1630C>G	c.(1630-1632)CGG>GGG	p.R544G	BRF1_uc010tyo.1_Missense_Mutation_p.R429G|BRF1_uc010typ.1_Missense_Mutation_p.R451G|BRF1_uc001yqk.2_Missense_Mutation_p.R70G|BRF1_uc001yql.2_Missense_Mutation_p.R340G|BRF1_uc001yqo.2_Missense_Mutation_p.R306G|BRF1_uc010axg.1_Missense_Mutation_p.R517G|BRF1_uc001yqn.2_Intron|BRF1_uc010axh.1_Intron|BRF1_uc010axi.1_Missense_Mutation_p.R70G	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	544					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		CTGAGGCCCCGGAGCACGCTA	0.637													5	3					0	0	0.001168	0	0
ADAM6	8755	broad.mit.edu	37	14	106237485	106237485	+	RNA	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:106237485G>A	uc010tyt.1	-	3611		c.57398C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysh.1_RNA|uc001ysi.1_RNA					Parts of antibodies, mostly variable regions.												0						CTGGGCTTGTGATTCACGTTG	0.627													15	33					0	0	0.007413	0	0
ADAM6	8755	broad.mit.edu	37	14	106630963	106630963	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:106630963C>T	uc010tyt.1	-	1079		c.25100_splice	c.e1079-1							Parts of antibodies, mostly variable regions.												0						GTCATCTCCTCTGTGTCAGCA	0.378													7	15					0	0	0.001984	0	0
ADAM6	8755	broad.mit.edu	37	14	107013315	107013315	+	RNA	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:107013315C>T	uc010tyt.1	-	169		c.7742G>A								Parts of antibodies, mostly variable regions.												0						CACTCATGTCCCCTCACACTC	0.468													19	23					0	0	0.006122	0	0
C15orf2	23742	broad.mit.edu	37	15	24922388	24922388	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:24922388C>T	uc001ywo.2	+	1	1848	c.1374C>T	c.(1372-1374)ATC>ATT	p.I458I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	458	Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CATTCACAATCCCTAACTCTC	0.498													24	43					0	0	0.002780	0	0
RYR3	6263	broad.mit.edu	37	15	33842517	33842517	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:33842517G>A	uc001zhi.2	+	10	1042	c.972G>A	c.(970-972)AAG>AAA	p.K324K	RYR3_uc010bar.2_Silent_p.K324K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	324	Cytoplasmic (By similarity).|MIR 4.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGCATCAAAGGTAAGGTGTG	0.468													6	10					0	0	0.001168	0	0
RYR3	6263	broad.mit.edu	37	15	33858941	33858941	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:33858941G>A	uc001zhi.2	+	12	1279	c.1209G>A	c.(1207-1209)GAG>GAA	p.E403E	RYR3_uc010bar.2_Silent_p.E403E	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	403	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCAGCGTGAGGAGTCCCAGG	0.517													28	35					0	0	0.007291	0	0
AQR	9716	broad.mit.edu	37	15	35202393	35202393	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:35202393G>A	uc001ziv.2	-	17	1787	c.1606C>T	c.(1606-1608)CGT>TGT	p.R536C		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	536						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ACATCTGCACGAACTCGGGTT	0.448													30	74					0	0	0.010818	0	0
B2M	567	broad.mit.edu	37	15	45003812	45003812	+	Splice_Site	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:45003812G>A	uc001zuc.2	+	1	127	c.67_splice	c.e1+1	p.R23_splice	B2M_uc010uek.1_Splice_Site_p.R23_splice|B2M_uc010bdx.1_Splice_Site_p.R23_splice	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GCTATCCAGCGTGAGTCTCTC	0.617													8	12					0	0	0.004482	0	0
HDC	3067	broad.mit.edu	37	15	50535050	50535050	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:50535050G>A	uc001zxz.2	-	12	1502	c.1396C>T	c.(1396-1398)CTC>TTC	p.L466F	HDC_uc001zxy.2_Missense_Mutation_p.L209F|HDC_uc010uff.1_Missense_Mutation_p.L433F	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	466					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TCTCGAATGAGATTCCAGTCT	0.527													9	13					0	0	0.006214	0	0
HDC	3067	broad.mit.edu	37	15	50535348	50535348	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:50535348G>A	uc001zxz.2	-	11	1340	c.1234C>T	c.(1234-1236)CGT>TGT	p.R412C	HDC_uc001zxy.2_Missense_Mutation_p.R155C|HDC_uc010uff.1_Missense_Mutation_p.R379C	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	412					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACCTTTAGACGAAAAACCACC	0.478													14	12					0	0	0.001855	0	0
SCG3	29106	broad.mit.edu	37	15	51981460	51981460	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:51981460G>A	uc002abh.2	+	6	993	c.585G>A	c.(583-585)GAG>GAA	p.E195E	SCG3_uc010ufz.1_5'UTR	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	195					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		AAGTAGCAGAGGTTTTACAAA	0.373													13	17					0	0	0.002450	0	0
UNC13C	440279	broad.mit.edu	37	15	54586225	54586225	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:54586225G>A	uc002ack.2	+	9	3951	c.3951G>A	c.(3949-3951)AGG>AGA	p.R1317R	UNC13C_uc002acl.2_Silent_p.R147R	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1317					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TAGAAGTGAGGACCTTGAGTG	0.363													32	53					0	0	0.006999	0	0
ADAM10	102	broad.mit.edu	37	15	58902632	58902632	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:58902632G>A	uc002afd.1	-	14	2333	c.1889C>T	c.(1888-1890)TCC>TTC	p.S630F	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.S329F|ADAM10_uc002afe.1_Intron|ADAM10_uc002aff.1_Missense_Mutation_p.S167F	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	630	Extracellular (Potential).|Cys-rich.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		GTTGCAAGGGGATCCAGGTTG	0.468													17	32					0	0	0.004990	0	0
ZNF609	23060	broad.mit.edu	37	15	64970588	64970588	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:64970588C>T	uc002ann.2	+	5	3676	c.3676C>T	c.(3676-3678)CCC>TCC	p.P1226S		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	1226						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GTCCTACATCCCCTACATGCA	0.602													14	41					0	0	0.006122	0	0
DENND4A	10260	broad.mit.edu	37	15	65962215	65962216	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:65962215_65962216GG>AA	uc002aph.2	-	26	4934_4935	c.4556_4557CC>TT	c.(4555-4557)TCC>TTT	p.S1519F	DENND4A_uc002api.2_Missense_Mutation_p.S1562F	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1519					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TTGAAATGGAGGATGGAAAGTG	0.386													22	19					0	0	0.004672	0	0
LARP6	55323	broad.mit.edu	37	15	71125175	71125175	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:71125175C>T	uc002ass.2	-	3	763	c.692G>A	c.(691-693)CGG>CAG	p.R231Q		NM_018357	NP_060827	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	231					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0						TTTGAGGATCCGCACTGATGA	0.582													8	15					0	0	0.003080	0	0
THSD4	79875	broad.mit.edu	37	15	72037448	72037448	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:72037448C>T	uc002atb.1	+	11	1989	c.1910C>T	c.(1909-1911)TCG>TTG	p.S637L	THSD4_uc002ate.2_Missense_Mutation_p.S277L	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	637						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GTTGCAGGATCGCAGTACCCT	0.547													90	116					0	0	0.014410	0	0
HCN4	10021	broad.mit.edu	37	15	73622119	73622119	+	Missense_Mutation	SNP	C	T	T	rs146714274		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:73622119C>T	uc002avp.2	-	4	2379	c.1385G>A	c.(1384-1386)GGG>GAG	p.G462E		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	462	Extracellular (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GTACTGCTTCCCCCAGGAGTT	0.622													7	12					0	0	0.003080	0	0
STRA6	64220	broad.mit.edu	37	15	74476282	74476283	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:74476282_74476283GG>AA	uc002axk.2	-	14	1396_1397	c.1214_1215CC>TT	c.(1213-1215)CCC>CTT	p.P405L	STRA6_uc002axi.2_Missense_Mutation_p.P214L|STRA6_uc010ulh.1_Missense_Mutation_p.P443L|STRA6_uc002axj.2_Missense_Mutation_p.P444L|STRA6_uc010bji.2_Missense_Mutation_p.P405L|STRA6_uc002axl.2_Missense_Mutation_p.P337L|STRA6_uc002axm.2_Missense_Mutation_p.P405L|STRA6_uc002axn.2_Missense_Mutation_p.P396L|STRA6_uc010uli.1_Missense_Mutation_p.P442L|STRA6_uc010bjj.1_RNA	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	405	Extracellular (Potential).				adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1						TCCGATGCAAGGGACTCAAGTC	0.594													21	17					0	0	0.004672	0	0
ARID3B	10620	broad.mit.edu	37	15	74836479	74836479	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:74836479C>T	uc002aye.2	+	2	403	c.202C>T	c.(202-204)CCC>TCC	p.P68S	ARID3B_uc002ayc.2_Missense_Mutation_p.P68S|ARID3B_uc002ayd.2_Missense_Mutation_p.P68S	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						TCCCTTAGGTCCCTTAGCCAG	0.562													12	12					0	0	0.001855	0	0
HOMER2	9455	broad.mit.edu	37	15	83561583	83561583	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:83561583T>C	uc002bjg.2	-	2	202	c.16A>G	c.(16-18)ATC>GTC	p.I6V	HOMER2_uc002bjh.2_Missense_Mutation_p.I6V|HOMER2_uc002bjj.2_Missense_Mutation_p.I6V|HOMER2_uc002bji.2_Missense_Mutation_p.I6V	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	6	WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						GTGGTGAAGATGGGCTGTTCT	0.478													31	33					0	0	0.003271	0	0
SH3GL3	6457	broad.mit.edu	37	15	84245343	84245343	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:84245343G>A	uc002bjw.2	+	6	669	c.474G>A	c.(472-474)CTG>CTA	p.L158L	SH3GL3_uc010uot.1_Silent_p.L158L|SH3GL3_uc002bjx.2_Silent_p.L89L|SH3GL3_uc002bju.2_Silent_p.L166L|SH3GL3_uc002bjv.2_RNA	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	158	BAR.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			pancreas(1)|central_nervous_system(1)|skin(1)	3						AGCATCACCTGAAAAAGCTGG	0.388													16	21					0	0	0.006122	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85165263	85165263	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:85165263C>T	uc002bkr.2	+	3	2063	c.1837C>T	c.(1837-1839)CTT>TTT	p.L613F	ZSCAN2_uc010bmz.1_Missense_Mutation_p.L611F|ZSCAN2_uc010bna.2_Missense_Mutation_p.L463F|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	613					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GAAAGAGAAACTTTATTGAAG	0.493													27	24					0	0	0.004656	0	0
ZNF592	9640	broad.mit.edu	37	15	85326156	85326156	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:85326156G>A	uc002bld.2	+	4	586	c.250G>A	c.(250-252)GAC>AAC	p.D84N	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	84					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCGGAGAAAGACCACATTAC	0.512													14	37					0	0	0.002450	0	0
NTRK3	4916	broad.mit.edu	37	15	88476251	88476251	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:88476251C>T	uc002bme.1	-	15	2043	c.1881G>A	c.(1879-1881)AAG>AAA	p.K627K	NTRK3_uc002bmh.2_Silent_p.K619K|NTRK3_uc002bmf.1_Silent_p.K627K|NTRK3_uc010upl.1_Silent_p.K529K|NTRK3_uc010bnh.1_Silent_p.K619K	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	627	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			ACCTGAGGAACTTATTCAGGT	0.517			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			14	15					0	0	0.004007	0	0
ACAN	176	broad.mit.edu	37	15	89398549	89398549	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:89398549C>T	uc010upo.1	+	12	3107	c.2733C>T	c.(2731-2733)GGC>GGT	p.G911G	ACAN_uc010upp.1_Silent_p.G911G|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	911					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGGGCTCAGGCCTGCCTGTGG	0.582													15	7					0	0	0.002450	0	0
RHCG	51458	broad.mit.edu	37	15	90021107	90021107	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:90021107G>A	uc002bnz.2	-	6	960	c.936C>T	c.(934-936)GTC>GTT	p.V312V	RHCG_uc002bny.2_Silent_p.V83V|RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Silent_p.V196V	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	312	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TGATGCCGCAGACGAAGCCGA	0.587													14	16					0	0	0.003163	0	0
FES	2242	broad.mit.edu	37	15	91432627	91432627	+	Missense_Mutation	SNP	C	G	G	rs149847085	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:91432627C>G	uc002bpv.2	+	6	856	c.760C>G	c.(760-762)CGC>GGC	p.R254G	FES_uc010uqj.1_Missense_Mutation_p.R196G|FES_uc010uqk.1_Missense_Mutation_p.R236G|FES_uc002bpw.2_RNA|FES_uc010bny.2_Missense_Mutation_p.R196G|FES_uc002bpx.2_Missense_Mutation_p.R254G|FES_uc002bpy.2_Missense_Mutation_p.R196G	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	254	Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			AGCTGCTGCCCGCATCCAGCC	0.632													81	97					0	0	0.014410	0	0
LRRK1	79705	broad.mit.edu	37	15	101593484	101593484	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:101593484C>T	uc002bwr.2	+	26	4232	c.3913C>T	c.(3913-3915)CGG>TGG	p.R1305W	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1305	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTCCGAGTTCCGGCAGGAGGC	0.662													8	15					0	0	0.003080	0	0
NTHL1	4913	broad.mit.edu	37	16	2097828	2097828	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:2097828G>A	uc002col.1	-	1	40	c.21C>T	c.(19-21)TCC>TCT	p.S7S	NTHL1_uc002com.1_Silent_p.S7S|TSC2_uc010uvu.1_5'Flank|TSC2_uc002con.2_5'Flank|TSC2_uc010bsd.2_5'Flank|TSC2_uc002coo.2_5'Flank|TSC2_uc010uvv.1_5'Flank|TSC2_uc010uvw.1_5'Flank|TSC2_uc002cop.2_5'Flank	NM_002528	NP_002519	P78549	NTHL1_HUMAN	nth endonuclease III-like 1	7					depyrimidination|nucleotide-excision repair, DNA incision, 5'-to lesion	nucleoplasm	4 iron, 4 sulfur cluster binding|double-stranded DNA binding|endonuclease activity|metal ion binding|oxidized pyrimidine base lesion DNA N-glycosylase activity|protein binding			lung(1)	1						CGGTCATGCCGGACTCCTGCG	0.711								BER_DNA_glycosylases					3	3					0	0	0.004672	0	0
ZNF205	7755	broad.mit.edu	37	16	3169264	3169264	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:3169264C>T	uc002cub.2	+	7	738	c.603C>T	c.(601-603)GTC>GTT	p.V201V	ZNF205_uc002cua.2_Silent_p.V201V	NM_001042428	NP_001035893	O95201	ZN205_HUMAN	zinc finger protein 205	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						CAGGAGCCGTCGAGGTGGGGC	0.617													12	36					0	0	0.004007	0	0
OR1F1	4992	broad.mit.edu	37	16	3254454	3254454	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:3254454G>A	uc010uwu.1	+	1	208	c.208G>A	c.(208-210)GAC>AAC	p.D70N		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTTTTGTGGACATCTGCTT	0.527													44	59					0	0	0.014410	0	0
C16orf90	646174	broad.mit.edu	37	16	3545419	3545419	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:3545419C>T	uc002cvi.2	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001080524	NP_001073993	A8MZG2	CP090_HUMAN	hypothetical protein LOC646174	Error:Variant_position_missing_in_A8MZG2_after_alignment											0						CCAAGGCTTCCATGGAGGGCC	0.617													4	12					0	0	0.009096	0	0
GLYR1	84656	broad.mit.edu	37	16	4867659	4867659	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:4867659G>A	uc002cxx.3	-	10	883	c.846C>T	c.(844-846)ATC>ATT	p.I282I	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Silent_p.I196I|GLYR1_uc002cya.2_Silent_p.I282I|GLYR1_uc010uxv.1_Silent_p.I201I	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	282	NAD (By similarity).				pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						AGTTGGAGACGATTCCACTTC	0.502													20	51					0	0	0.010504	0	0
TMC5	79838	broad.mit.edu	37	16	19474639	19474639	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:19474639C>T	uc002dgc.3	+	7	1935	c.1186C>T	c.(1186-1188)CGT>TGT	p.R396C	TMC5_uc010vaq.1_Missense_Mutation_p.R396C|TMC5_uc002dgb.3_Missense_Mutation_p.R396C|TMC5_uc010var.1_Missense_Mutation_p.R396C|TMC5_uc002dgd.1_Missense_Mutation_p.R150C|TMC5_uc002dge.3_Missense_Mutation_p.R150C|TMC5_uc002dgf.3_Missense_Mutation_p.R79C|TMC5_uc002dgg.3_Missense_Mutation_p.R37C	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	396	Extracellular (Potential).					integral to membrane				skin(1)	1						ACAGACCCATCGTATCCTTCA	0.408													24	22					0	0	0.004656	0	0
TMC5	79838	broad.mit.edu	37	16	19485494	19485494	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:19485494C>T	uc002dgc.3	+	12	2735	c.1986C>T	c.(1984-1986)TTC>TTT	p.F662F	TMC5_uc010vaq.1_Silent_p.F610F|TMC5_uc002dgb.3_Silent_p.F662F|TMC5_uc010var.1_Silent_p.F662F|TMC5_uc002dgd.1_Silent_p.F416F|TMC5_uc002dge.3_Silent_p.F416F|TMC5_uc002dgf.3_Silent_p.F345F|TMC5_uc002dgg.3_Silent_p.F303F	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	662	Helical; (Potential).					integral to membrane				skin(1)	1						TACTGCCTTTCGTTGTGTCCT	0.547													15	71					0	0	0.003163	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251757	25251757	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:25251757G>A	uc002dod.3	-	7	2691	c.2284C>T	c.(2284-2286)CGT>TGT	p.R762C	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.R558C	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	762					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		CACATCAGACGAGTGCTCCTT	0.502													12	29					0	0	0.010729	0	0
CD19	930	broad.mit.edu	37	16	28944319	28944319	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:28944319C>T	uc002drs.2	+	3	505	c.443C>T	c.(442-444)TCC>TTC	p.S148F	uc010vct.1_Intron|CD19_uc010byo.1_Missense_Mutation_p.S148F	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	148	Extracellular (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						AGCTCCCCTTCCGGGAAGCTC	0.632													4	7					0	0	0.001168	0	0
MAPK3	5595	broad.mit.edu	37	16	30129013	30129013	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:30129013C>T	uc002dws.2	-	5	853	c.753G>A	c.(751-753)CTG>CTA	p.L251L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Silent_p.L137L|MAPK3_uc002dwv.3_Silent_p.L251L|MAPK3_uc002dwt.2_Silent_p.L251L|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	251	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TGAGCTGATCCAGGTAGTGCT	0.562													12	49					0	0	0.004007	0	0
ITGAL	3683	broad.mit.edu	37	16	30522415	30522415	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:30522415C>T	uc002dyi.3	+	24	2920	c.2744C>T	c.(2743-2745)ACC>ATC	p.T915I	ITGAL_uc002dyj.3_Missense_Mutation_p.T831I|ITGAL_uc010vev.1_Missense_Mutation_p.T149I	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	915	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity	p.T915I(1)		ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	TCAGCCACTACCATCATCCCC	0.567													31	35					0	0	0.003271	0	0
GPR97	222487	broad.mit.edu	37	16	57707263	57707263	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:57707263A>C	uc002emh.2	+	2	192	c.89A>C	c.(88-90)AAC>ACC	p.N30T	GPR97_uc010cdc.2_Missense_Mutation_p.N30T|GPR97_uc010vhv.1_5'UTR|GPR97_uc010cdd.2_RNA	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	30	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GGGCCAAGAAACACCTGCCTG	0.448													7	32					0	0	0.001984	0	0
AGRP	181	broad.mit.edu	37	16	67516960	67516960	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:67516960C>T	uc002etg.1	-	3	484	c.184G>A	c.(184-186)GAT>AAT	p.D62N	ATP6V0D1_uc002ete.1_5'Flank|ATP6V0D1_uc010vjo.1_5'Flank	NM_001138	NP_001129	O00253	AGRP_HUMAN	agouti related protein homolog isoform 1	62					hormone-mediated signaling pathway|neuropeptide signaling pathway|regulation of feeding behavior	extracellular space|Golgi lumen	neuropeptide hormone activity				0		Acute lymphoblastic leukemia(13;0.00263)|all_hematologic(13;0.0274)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0717)|Epithelial(162;0.16)		TGCAACAGATCCTCTTCTGCC	0.607													24	33					0	0	0.006320	0	0
WWP2	11060	broad.mit.edu	37	16	69965107	69965107	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:69965107C>T	uc002exu.1	+	15	1587	c.1498C>T	c.(1498-1500)CAC>TAC	p.H500Y	WWP2_uc002exv.1_Missense_Mutation_p.H500Y|WWP2_uc010vlm.1_Missense_Mutation_p.H384Y|WWP2_uc010vln.1_Missense_Mutation_p.H118Y|WWP2_uc002exw.1_Missense_Mutation_p.H61Y|uc002exx.1_5'Flank|MIR140_hsa-mir-140|MI0000456_5'Flank	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	500				H->K: Does not affect FBXL15-mediated ubiquitination.	entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						GTGGAAGTATCACCAGTTCCG	0.507													17	46					0	0	0.010504	0	0
HYDIN	54768	broad.mit.edu	37	16	70917885	70917885	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:70917885C>T	uc002ezr.2	-	59	10042	c.9914G>A	c.(9913-9915)CGA>CAA	p.R3305Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3306										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TGCAGGGTCTCGGCCGGAGAT	0.537													5	25					0	0	0.001168	0	0
CHST4	10164	broad.mit.edu	37	16	71570949	71570949	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:71570949C>T	uc002fan.2	+	2	550	c.369C>T	c.(367-369)CTC>CTT	p.L123L	CHST4_uc002fao.2_Silent_p.L123L	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	123	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGTCCAGCCTCTTTCAGTGGG	0.582													6	38					0	0	0.004482	0	0
MARVELD3	91862	broad.mit.edu	37	16	71674823	71674823	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:71674823G>A	uc002fau.2	+	3	1189	c.1126G>A	c.(1126-1128)GTG>ATG	p.V376M	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	379	MARVEL.|Helical; (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				CGCCAGCGTGGTGCTGGCCCT	0.597													11	12					0	0	0.008291	0	0
PMFBP1	83449	broad.mit.edu	37	16	72164148	72164148	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:72164148C>T	uc002fcc.3	-	12	1933	c.1761G>A	c.(1759-1761)ATG>ATA	p.M587I	PMFBP1_uc002fcd.2_Missense_Mutation_p.M582I|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Missense_Mutation_p.M437I|PMFBP1_uc010cgo.1_5'Flank	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	587	Potential.									ovary(2)	2		Ovarian(137;0.179)				CATTCATTTTCATATCCTGCT	0.448													21	65					0	0	0.002780	0	0
ZFHX3	463	broad.mit.edu	37	16	72821201	72821201	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:72821201G>A	uc002fck.2	-	10	11647	c.10974C>T	c.(10972-10974)GAC>GAT	p.D3658D	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.D2744D	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3658					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CCGAATAGTCGTCTGTTGGCA	0.597													45	47					0	0	0.010771	0	0
GLG1	2734	broad.mit.edu	37	16	74524922	74524922	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:74524922G>A	uc002fcy.3	-	8	1476	c.1426C>T	c.(1426-1428)CTT>TTT	p.L476F	GLG1_uc002fcx.2_Missense_Mutation_p.L476F|GLG1_uc002fcw.3_Missense_Mutation_p.L465F|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	476	Extracellular (Potential).|Cys-rich GLG1 7.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TTCATTCCAAGGTTCCCCTTC	0.498													12	48					0	0	0.002450	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369756	77369756	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:77369756G>A	uc002ffc.3	-	12	2175	c.1756C>T	c.(1756-1758)CGG>TGG	p.R586W	ADAMTS18_uc010chc.1_Missense_Mutation_p.R174W|ADAMTS18_uc002ffe.1_Missense_Mutation_p.R282W	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	586					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGGATGGGCCGGGGCCCGAGC	0.587													19	74					0	0	0.003954	0	0
BCMO1	53630	broad.mit.edu	37	16	81319193	81319193	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:81319193G>A	uc002fgn.1	+	9	1474	c.1256G>A	c.(1255-1257)CGA>CAA	p.R419Q	BCMO1_uc010vnp.1_Missense_Mutation_p.R350Q	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	419					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						AAGCAATACCGATATGTCTTT	0.478													14	41					0	0	0.004007	0	0
KIAA0182	23199	broad.mit.edu	37	16	85688528	85688528	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:85688528C>T	uc002fix.2	+	5	802	c.728C>T	c.(727-729)CCG>CTG	p.P243L	KIAA0182_uc002fiw.2_Missense_Mutation_p.P139L|KIAA0182_uc002fiy.2_Missense_Mutation_p.P170L	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	243							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						GGCCTGGACCCGGCCACTGCT	0.682													5	11					0	0	0.001168	0	0
MTHFSD	64779	broad.mit.edu	37	16	86565627	86565627	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:86565627C>T	uc002fjn.2	-	8	1193	c.1142G>A	c.(1141-1143)AGG>AAG	p.R381K	MTHFSD_uc010voo.1_Missense_Mutation_p.R361K|MTHFSD_uc002fjo.2_Missense_Mutation_p.R218K|MTHFSD_uc002fjm.2_Missense_Mutation_p.R380K|MTHFSD_uc010vop.1_Missense_Mutation_p.R218K|MTHFSD_uc010voq.1_Missense_Mutation_p.R380K|MTHFSD_uc010vor.1_Missense_Mutation_p.R381K	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	381					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						TCACTTGTCCCTCTGCTGCCT	0.697													5	0					0	0	0.001168	0	0
FANCA	2175	broad.mit.edu	37	16	89813022	89813022	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr16:89813022C>T	uc002fou.1	-	35	3525	c.3483G>A	c.(3481-3483)ACG>ACA	p.T1161T	FANCA_uc010vpn.1_Silent_p.T1161T|FANCA_uc010vpo.1_Silent_p.T247T	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1161					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		AGGGGCATTTCGTCTGGCACT	0.562			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				5	25					0	0	0.001168	0	0
ATP2A3	489	broad.mit.edu	37	17	3856722	3856723	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:3856722_3856723CC>TT	uc002fxb.1	-	3	288_289	c.137_138GG>AA	c.(136-138)GGG>GAA	p.G46E	ATP2A3_uc002fwx.1_Missense_Mutation_p.G46E|ATP2A3_uc002fwy.1_Missense_Mutation_p.G46E|ATP2A3_uc002fwz.1_Missense_Mutation_p.G46E|ATP2A3_uc002fxa.1_Missense_Mutation_p.G46E|ATP2A3_uc002fxc.1_Missense_Mutation_p.G46E|ATP2A3_uc002fxd.1_Missense_Mutation_p.G46E	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	46	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		ACAGGGACTTCCCTGGGAACGG	0.653													5	17					0	0	0.004672	0	0
ZFP3	124961	broad.mit.edu	37	17	4994885	4994885	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:4994885C>T	uc002gaq.2	+	2	211	c.86C>T	c.(85-87)CCA>CTA	p.P29L		NM_153018	NP_694563	Q96NJ6	ZFP3_HUMAN	zinc finger protein-3	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAAATTTCCAAAAGTGGTT	0.423													29	20					0	0	0.008361	0	0
DNAH2	146754	broad.mit.edu	37	17	7662210	7662210	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:7662210T>G	uc002giu.1	+	14	2230	c.2216T>G	c.(2215-2217)ATG>AGG	p.M739R		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	739	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TAGGTGCAGATGATTGTGAAT	0.537													6	21					0	0	0.001168	0	0
MYH10	4628	broad.mit.edu	37	17	8393840	8393840	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:8393840G>A	uc002gll.2	-	33	4705	c.4609C>T	c.(4609-4611)CTA>TTA	p.L1537L	MYH10_uc002glm.2_Silent_p.L1568L|MYH10_uc010cnx.2_Silent_p.L1546L	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1537	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TGCTGCTCTAGGGCCCGTTTG	0.532													23	26					0	0	0.003330	0	0
USP43	124739	broad.mit.edu	37	17	9590171	9590171	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:9590171A>G	uc010cod.2	+	8	1298	c.1298A>G	c.(1297-1299)CAG>CGG	p.Q433R	USP43_uc002gma.3_Missense_Mutation_p.Q122R|USP43_uc010vva.1_Missense_Mutation_p.Q433R|USP43_uc010coe.2_Missense_Mutation_p.Q230R	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	433					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCCAGCTCCAGCAGTCTATC	0.428													3	24					0	0	0.009096	0	0
GLP2R	9340	broad.mit.edu	37	17	9783724	9783724	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:9783724C>T	uc002gmd.1	+	11	1175	c.1175C>T	c.(1174-1176)CCT>CTT	p.P392L		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	392	Helical; Name=6; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	GTCCTCATTCCTTTATTGGGC	0.413													65	71					0	0	0.014410	0	0
MYH13	8735	broad.mit.edu	37	17	10206725	10206725	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:10206725C>T	uc002gmk.1	-	38	5647	c.5557G>A	c.(5557-5559)GAG>AAG	p.E1853K		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1853	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TAAGTCATCTCCTTGACTTTG	0.547													36	30					0	0	0.004289	0	0
MYH8	4626	broad.mit.edu	37	17	10304037	10304037	+	Silent	SNP	C	T	T	rs78443907	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:10304037C>T	uc002gmm.2	-	27	3500	c.3405G>A	c.(3403-3405)GCG>GCA	p.A1135A	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1135	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						GCTGCTTCTCCGCTTTGGCTC	0.557									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				33	18					0	0	0.003271	0	0
MYH4	4622	broad.mit.edu	37	17	10361017	10361017	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:10361017C>T	uc002gmn.2	-	16	1728	c.1617G>A	c.(1615-1617)GAG>GAA	p.E539E	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	539	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						ACATGCACTCCTCTTCTAGGA	0.438													21	64					0	0	0.014323	0	0
MYH2	4620	broad.mit.edu	37	17	10429146	10429146	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:10429146G>A	uc010coi.2	-	31	4363	c.4235C>T	c.(4234-4236)GCT>GTT	p.A1412V	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.A1412V|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1412	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GGCGTTCACAGCTTCTACATG	0.483													25	31					0	0	0.005443	0	0
DNAH9	1770	broad.mit.edu	37	17	11520784	11520784	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:11520784G>A	uc002gne.2	+	5	1029	c.961G>A	c.(961-963)GAA>AAA	p.E321K		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	321	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCGCCACCTGGAAGCTCTGGA	0.577													5	18					0	0	0.000602	0	0
MPRIP	23164	broad.mit.edu	37	17	17049351	17049352	+	Missense_Mutation	DNP	CC	TT	TT	rs139934070	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:17049351_17049352CC>TT	uc002gqu.1	+	10	1207_1208	c.1151_1152CC>TT	c.(1150-1152)CCC>CTT	p.P384L	MPRIP_uc002gqv.1_Missense_Mutation_p.P384L|MPRIP_uc002gqw.1_Missense_Mutation_p.P139L	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	384						cytoplasm|cytoskeleton	actin binding				0						CTTTCTCAGCCCGACCTGCTGA	0.545													6	13					0	0	0.004672	0	0
MYO15A	51168	broad.mit.edu	37	17	18023226	18023226	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:18023226C>T	uc010vxh.1	+	2	1450	c.1112C>T	c.(1111-1113)CCC>CTC	p.P371L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	371	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TACTTTGATCCCTACGGAGTC	0.592													14	37					0	0	0.001855	0	0
GRAP	10750	broad.mit.edu	37	17	18925352	18925352	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:18925352C>T	uc002guy.2	-	5	671	c.574G>A	c.(574-576)GAC>AAC	p.D192N		NM_006613	NP_006604	Q13588	GRAP_HUMAN	GRB2-related adaptor protein	192	SH3 2.				cell-cell signaling|Ras protein signal transduction	cytoplasm	SH3/SH2 adaptor activity				0	all_cancers(12;0.0183)					CAGTGGGGGTCTGGGCGCTCC	0.687													3	9					0	0	0.004672	0	0
ALDOC	230	broad.mit.edu	37	17	26901211	26901211	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:26901211C>T	uc002hbp.2	-	7	818	c.673G>A	c.(673-675)GAG>AAG	p.E225K	PIGS_uc002hbn.2_5'Flank|PIGS_uc002hbo.2_5'Flank|PIGS_uc010wap.1_5'Flank|ALDOC_uc010cro.2_Missense_Mutation_p.E197K	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	225					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					AGGGTCCCCTCCAGGTATACA	0.582													54	46					0	0	0.014410	0	0
RHBDL3	162494	broad.mit.edu	37	17	30648009	30648009	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:30648009C>T	uc002hhe.1	+	9	990	c.976C>T	c.(976-978)CGC>TGC	p.R326C	RHBDL3_uc010csw.1_Missense_Mutation_p.R318C|RHBDL3_uc010csx.1_Missense_Mutation_p.P292L|RHBDL3_uc010csy.1_Missense_Mutation_p.R228C|RHBDL3_uc002hhf.1_Missense_Mutation_p.R228C	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	326					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				CGTGTGGCTCCGCTTCCACCC	0.662													14	28					0	0	0.001855	0	0
PIGW	284098	broad.mit.edu	37	17	34893408	34893408	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:34893408C>A	uc002hmy.1	+	2	501	c.458C>A	c.(457-459)CCC>CAC	p.P153H	MYO19_uc002hmw.2_5'Flank|MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Missense_Mutation_p.P153H	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	153					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCACTTTTTCCCAGAAGATTT	0.443													7	147					0.00307968	0.00962559	0.003080	1	0
LHX1	3975	broad.mit.edu	37	17	35300123	35300123	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:35300123C>T	uc002hnh.1	+	5	1912	c.916C>T	c.(916-918)CAG>TAG	p.Q306*		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	306					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				CTCGCAGGCCCAGACACCAGT	0.716													3	2					0	0	0.004672	0	0
KRT24	192666	broad.mit.edu	37	17	38859788	38859788	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:38859788C>T	uc002hvd.2	-	1	215	c.158G>A	c.(157-159)AGT>AAT	p.S53N		NM_019016	NP_061889	Q2M2I5	K1C24_HUMAN	keratin 24	53	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)				AGACCCCCCACTCAGGCTGCA	0.637													14	18					0	0	0.002450	0	0
KRT26	353288	broad.mit.edu	37	17	38923894	38923894	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:38923894G>A	uc002hvf.2	-	7	1245	c.1199C>T	c.(1198-1200)TCC>TTC	p.S400F		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	400	Tail.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				GTAACATGTGGATTTGCTTTT	0.318													25	37					0	0	0.008361	0	0
STAT3	6774	broad.mit.edu	37	17	40485919	40485919	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:40485919A>T	uc002hzl.1	-	9	1186	c.946T>A	c.(946-948)TTA>ATA	p.L316I	STAT3_uc002hzk.1_Missense_Mutation_p.L316I|STAT3_uc002hzm.1_Missense_Mutation_p.L316I|STAT3_uc010wgh.1_Missense_Mutation_p.L218I|STAT3_uc002hzn.1_Missense_Mutation_p.L316I	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	316					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CTTTTCATTAAGTTTCTAAAC	0.468									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				27	14					0	0	0.006320	0	0
C17orf104	284071	broad.mit.edu	37	17	42745072	42745072	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:42745072G>A	uc010czv.2	+	5	1793	c.1793G>A	c.(1792-1794)GGG>GAG	p.G598E	C17orf104_uc002igy.1_Missense_Mutation_p.G432E|C17orf104_uc002igz.3_Missense_Mutation_p.G432E|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Missense_Mutation_p.G432E	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	598										central_nervous_system(1)	1						CAGAAGTATGGGATAATTGAA	0.358													10	6					0	0	0.006214	0	0
TOM1L1	10040	broad.mit.edu	37	17	53014064	53014064	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:53014064C>T	uc002iud.2	+	9	1084	c.909C>T	c.(907-909)GCC>GCT	p.A303A	TOM1L1_uc002iuc.2_Silent_p.A303A|TOM1L1_uc010dca.1_Silent_p.A303A|TOM1L1_uc010wnb.1_Silent_p.A296A|TOM1L1_uc010wnc.1_Silent_p.A226A|TOM1L1_uc010dbz.2_Silent_p.A226A|TOM1L1_uc010wnd.1_Silent_p.A191A|TOM1L1_uc010dcb.1_RNA	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	303					intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						AGAAGGAAGCCACCAATGTAA	0.303													5	37					0	0	0.000602	0	0
BZRAP1	9256	broad.mit.edu	37	17	56403732	56403732	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:56403732C>T	uc002ivx.3	-	3	1363	c.492G>A	c.(490-492)AGG>AGA	p.R164R	BZRAP1_uc010dcs.2_Silent_p.R164R|BZRAP1_uc010wnt.1_Silent_p.R164R|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	164						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGCGTTCTTCCTCTTCAGCC	0.607													24	24					0	0	0.004656	0	0
MRC2	9902	broad.mit.edu	37	17	60742014	60742014	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:60742014A>C	uc002jad.2	+	2	626	c.224A>C	c.(223-225)CAG>CCG	p.Q75P	MRC2_uc002jac.2_Missense_Mutation_p.Q75P	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	75	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTCCCTGCCCAGCGCTGGAAG	0.652													5	34					0	0	0.000602	0	0
MRC2	9902	broad.mit.edu	37	17	60767588	60767588	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:60767588C>T	uc002jad.2	+	26	4216	c.3814C>T	c.(3814-3816)CCC>TCC	p.P1272S	MRC2_uc002jae.2_Missense_Mutation_p.P343S|MRC2_uc002jaf.2_Missense_Mutation_p.P138S	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1272	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CGCGTGGATTCCCTTCCGGGA	0.627													11	17					0	0	0.008291	0	0
ACE	1636	broad.mit.edu	37	17	61568744	61568744	+	Splice_Site	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:61568744T>C	uc002jau.1	+	19	2934	c.2912_splice	c.e19+2	p.R971_splice	ACE_uc002jav.1_Splice_Site_p.R397_splice|ACE_uc010ddv.1_Splice_Site_p.R198_splice|ACE_uc010wpj.1_Splice_Site_p.R397_splice|ACE_uc002jaw.1_Splice_Site|ACE_uc010wpk.1_Splice_Site_p.R217_splice	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1						arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGACTTCCGGTACATCCAGCT	0.612													27	21					0	0	0.008361	0	0
ARSG	22901	broad.mit.edu	37	17	66339772	66339772	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:66339772C>T	uc002jhc.2	+	3	1042	c.246C>T	c.(244-246)TCC>TCT	p.S82S	ARSG_uc002jhb.1_5'UTR	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	82					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAGCTGCCTCCACCTGCTCAC	0.592													7	24					0	0	0.004482	0	0
ABCA8	10351	broad.mit.edu	37	17	66938086	66938086	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:66938086G>A	uc002jhp.2	-	2	269	c.90C>T	c.(88-90)TCC>TCT	p.S30S	ABCA8_uc002jhq.2_Silent_p.S30S|ABCA8_uc010wqq.1_Silent_p.S30S|ABCA8_uc010wqr.1_Intron|ABCA8_uc002jhr.2_Silent_p.S30S|ABCA8_uc002jhs.2_Silent_p.S30S|ABCA8_uc002jht.2_Silent_p.S30S	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	30	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ATACCATTAAGGACTCTCTTT	0.378													22	47					0	0	0.010504	0	0
ABCA6	23460	broad.mit.edu	37	17	67129904	67129904	+	Silent	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:67129904A>G	uc002jhw.1	-	6	844	c.669T>C	c.(667-669)TTT>TTC	p.F223F		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	223	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					AGAATAAAATAAACATCTCAT	0.318													10	35					0	0	0.010729	0	0
ACOX1	51	broad.mit.edu	37	17	73945838	73945838	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:73945838G>A	uc002jqf.2	-	10	1729	c.1439C>T	c.(1438-1440)CCC>CTC	p.P480L	ACOX1_uc010wsq.1_Missense_Mutation_p.P442L|ACOX1_uc002jqe.2_Missense_Mutation_p.P480L|ACOX1_uc010wsr.1_Missense_Mutation_p.P412L	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	480					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						TAGGCTTTCGGGGCTGTTGAT	0.567													16	40					0	0	0.003163	0	0
BAIAP2	10458	broad.mit.edu	37	17	79077486	79077486	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:79077486C>T	uc002jzg.2	+	8	935	c.827C>T	c.(826-828)CCC>CTC	p.P276L	BAIAP2_uc002jyz.3_Missense_Mutation_p.P276L|BAIAP2_uc002jza.2_Missense_Mutation_p.P276L|BAIAP2_uc002jzc.2_Missense_Mutation_p.P276L|BAIAP2_uc002jzb.2_Missense_Mutation_p.P33L|BAIAP2_uc002jzd.2_Missense_Mutation_p.P276L|BAIAP2_uc002jzf.2_Missense_Mutation_p.P276L|BAIAP2_uc002jze.2_Missense_Mutation_p.P309L|BAIAP2_uc010wuh.1_Missense_Mutation_p.P198L|BAIAP2_uc002jzh.2_Missense_Mutation_p.P277L|BAIAP2_uc010wui.1_Missense_Mutation_p.P139L	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	276					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GGGGCCAAGCCCCTGCCGGTG	0.682													11	10					0	0	0.002450	0	0
CETN1	1068	broad.mit.edu	37	18	580847	580847	+	Missense_Mutation	SNP	G	A	A	rs143489830		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr18:580847G>A	uc002kko.1	+	1	481	c.439G>A	c.(439-441)GAC>AAC	p.D147N		NM_004066	NP_004057	Q12798	CETN1_HUMAN	centrin 1	147	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGAGATGATCGACGAAGCTGA	0.537													27	19					0	0	0.008361	0	0
DLGAP1	9229	broad.mit.edu	37	18	3567488	3567488	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr18:3567488C>T	uc002kmf.2	-	6	2124	c.2057G>A	c.(2056-2058)TGC>TAC	p.C686Y	DLGAP1_uc010wyz.1_Missense_Mutation_p.C686Y|DLGAP1_uc002kme.1_Missense_Mutation_p.C384Y|DLGAP1_uc010dkn.2_Missense_Mutation_p.C394Y|DLGAP1_uc010wyw.1_Missense_Mutation_p.C392Y|DLGAP1_uc010wyx.1_Missense_Mutation_p.C408Y|DLGAP1_uc010wyy.1_Missense_Mutation_p.C370Y|DLGAP1_uc002kmg.2_Missense_Mutation_p.C384Y	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	686					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GTGGACTTACCACTTCTCTTC	0.418													61	21					0	0	0.014410	0	0
DSG1	1828	broad.mit.edu	37	18	28934829	28934829	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr18:28934829G>A	uc002kwp.2	+	15	2882	c.2670G>A	c.(2668-2670)TCG>TCA	p.S890S	DSG1_uc010xbp.1_Silent_p.S249S	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	890	Cytoplasmic (Potential).|Desmoglein repeat 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GAGATGGGTCGAATGTTATAG	0.483													59	23					0	0	0.014410	0	0
DSG3	1830	broad.mit.edu	37	18	29040811	29040811	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr18:29040811C>T	uc002kws.2	+	7	809	c.700C>T	c.(700-702)CGT>TGT	p.R234C		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	234	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TAGCAGCTATCGTCTGGTTGT	0.338													19	6					0	0	0.012319	0	0
SERPINB3	6317	broad.mit.edu	37	18	61322896	61322896	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr18:61322896G>A	uc002lji.2	-	8	1312	c.1168C>T	c.(1168-1170)CCG>TCG	p.P390S	SERPINB4_uc002ljg.2_Intron|SERPINB3_uc010dqa.2_Missense_Mutation_p.P338S	NM_006919	NP_008850	P29508	SPB3_HUMAN	serine (or cysteine) proteinase inhibitor, clade	390					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGCATCTACGGGGATGAGAAT	0.398													55	32					0	0	0.014410	0	0
GAMT	2593	broad.mit.edu	37	19	1398961	1398961	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:1398961C>T	uc002lsj.2	-	5	601	c.524G>A	c.(523-525)GGG>GAG	p.G175E	uc002lsi.1_5'Flank|GAMT_uc002lsk.2_Missense_Mutation_p.G175E	NM_000156	NP_000147	Q14353	GAMT_HUMAN	guanidinoacetate N-methyltransferase isoform a	175					creatine biosynthetic process|muscle contraction	cytosol	guanidinoacetate N-methyltransferase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Lung NSC(49;0.000195)|Breast(49;0.000231)|all_lung(49;0.000247)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Creatine(DB00148)	CATCAGCTCCCCCCAGGAGGT	0.607													14	25					0	0	0.003163	0	0
FSD1	79187	broad.mit.edu	37	19	4317268	4317268	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:4317268G>A	uc002lzy.2	+	8	943	c.790G>A	c.(790-792)GAG>AAG	p.E264K	FSD1_uc002lzz.2_Missense_Mutation_p.E264K|FSD1_uc002maa.2_Missense_Mutation_p.E77K	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	264	Fibronectin type-III.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTGACTCTGGAGACACCAGG	0.537													23	30					0	0	0.003330	0	0
FSD1	79187	broad.mit.edu	37	19	4318404	4318404	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:4318404C>T	uc002lzy.2	+	9	1014	c.861C>T	c.(859-861)TCC>TCT	p.S287S	FSD1_uc002lzz.2_Silent_p.S287S|FSD1_uc002maa.2_Silent_p.S100S	NM_024333	NP_077309	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing	287	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGATCTCTCCGTGGAGTGGG	0.602													8	15					0	0	0.004482	0	0
PLIN4	729359	broad.mit.edu	37	19	4510976	4510976	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:4510976C>T	uc002mar.1	-	3	2954	c.2954G>A	c.(2953-2955)AGT>AAT	p.S985N	PLIN4_uc010dub.1_Missense_Mutation_p.S9N	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	985	27.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						GGTAACCCCACTGAAGACAGT	0.617													5	19					0	0	0.000602	0	0
TNFAIP8L1	126282	broad.mit.edu	37	19	4652031	4652031	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:4652031G>A	uc002max.2	+	2	265	c.150G>A	c.(148-150)ACG>ACA	p.T50T		NM_152362	NP_689575	Q8WVP5	TP8L1_HUMAN	tumor necrosis factor, alpha-induced protein	50											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAGTTCACGCGCAGCCGCA	0.637													4	15					0	0	0.000602	0	0
FCER2	2208	broad.mit.edu	37	19	7754204	7754204	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:7754204C>T	uc002mhn.2	-	11	1025	c.841G>A	c.(841-843)GTG>ATG	p.V281M	FCER2_uc010xjs.1_Missense_Mutation_p.V203M|FCER2_uc010xjt.1_Missense_Mutation_p.V203M|FCER2_uc002mhm.2_Missense_Mutation_p.V281M	NM_002002	NP_001993	P06734	FCER2_HUMAN	Fc fragment of IgE, low affinity II, receptor	281	C-type lectin.|Extracellular (Potential).				positive regulation of killing of cells of other organism|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of nitric-oxide synthase activity	extracellular region|integral to plasma membrane	IgE binding|integrin binding|receptor activity|sugar binding				0						CGGTCGCACACCCAGGCGCCC	0.697													10	19					0	0	0.008291	0	0
CLEC4G	339390	broad.mit.edu	37	19	7796641	7796641	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:7796641C>T	uc002mhp.3	-	2	141	c.72G>A	c.(70-72)TGG>TGA	p.W24*		NM_198492	NP_940894	Q6UXB4	CLC4G_HUMAN	C-type lectin domain family 4, member G	24	Cytoplasmic (Potential).					integral to membrane	protein binding|sugar binding				0						TCCAGTGCACCCAGCGTCCCC	0.547													7	14					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9048458	9048458	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9048458G>A	uc002mkp.2	-	5	33377	c.33173C>T	c.(33172-33174)CCA>CTA	p.P11058L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11060	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AATCAGAGTTGGAATACTTGT	0.488													21	31					0	0	0.012319	0	0
MUC16	94025	broad.mit.edu	37	19	9062685	9062685	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9062685C>T	uc002mkp.2	-	3	24965	c.24761G>A	c.(24760-24762)TGG>TAG	p.W8254*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8256	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGACTAGGCCATAACATATC	0.502													14	24					0	0	0.003163	0	0
MUC16	94025	broad.mit.edu	37	19	9066772	9066772	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9066772C>T	uc002mkp.2	-	3	20878	c.20674G>A	c.(20674-20676)GAA>AAA	p.E6892K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6894	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGTGGTTTCCACATTAGTC	0.488													38	100					0	0	0.006230	0	0
OR7D2	162998	broad.mit.edu	37	19	9296779	9296779	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9296779C>T	uc002mkz.1	+	1	510	c.322C>T	c.(322-324)CCT>TCT	p.P108S		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	108	Helical; Name=3; (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						CATGTTTTTTCCTATTCTGGA	0.512													22	84					0	0	0.004656	0	0
OR7D4	125958	broad.mit.edu	37	19	9325290	9325290	+	Missense_Mutation	SNP	G	A	A	rs5020281		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9325290G>A	uc002mla.1	-	1	224	c.224C>T	c.(223-225)TCC>TTC	p.S75F		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GACTGTGGTGGAGATGAAACA	0.502													17	34					0	0	0.004990	0	0
OR7E24	26648	broad.mit.edu	37	19	9362280	9362280	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:9362280C>T	uc002mlb.1	+	1	561	c.561C>T	c.(559-561)TTC>TTT	p.F187F		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCACCTGCTTCAAGGATGTGG	0.408													11	27					0	0	0.008291	0	0
ZNF700	90592	broad.mit.edu	37	19	12060739	12060739	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:12060739A>C	uc002msu.2	+	4	2026	c.1900A>C	c.(1900-1902)AAC>CAC	p.N634H	ZNF700_uc010xme.1_Missense_Mutation_p.N652H|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	634	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATCTGCCTCAAACCTTCAGAT	0.423													3	41					0	0	0.004672	0	0
NFIX	4784	broad.mit.edu	37	19	13135903	13135903	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:13135903C>T	uc010xmx.1	+	2	173	c.120C>T	c.(118-120)AAC>AAT	p.N40N	NFIX_uc002mwd.2_Silent_p.N32N|NFIX_uc002mwe.2_Silent_p.N24N|NFIX_uc002mwf.2_Silent_p.N35N|NFIX_uc002mwg.1_Silent_p.N31N			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	32	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CCTGGTTCAACCTGCAGGCGC	0.602													5	10					0	0	0.000602	0	0
CACNA1A	773	broad.mit.edu	37	19	13340940	13340940	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:13340940C>T	uc010dze.2	-	36	5723	c.5487G>A	c.(5485-5487)CTG>CTA	p.L1829L	CACNA1A_uc010xnd.1_Silent_p.L534L|CACNA1A_uc002mwx.3_Silent_p.L534L|CACNA1A_uc010dzc.2_Silent_p.L1354L|CACNA1A_uc002mwy.3_Silent_p.L1828L|CACNA1A_uc002mwv.3_Silent_p.L345L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1829	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGTACTCATCCAGGTGGTGGG	0.587													11	13					0	0	0.013537	0	0
CACNA1A	773	broad.mit.edu	37	19	13428134	13428134	+	Silent	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:13428134A>G	uc010dze.2	-	11	1586	c.1350T>C	c.(1348-1350)GGT>GGC	p.G450G	CACNA1A_uc010dzc.2_5'UTR|CACNA1A_uc002mwy.3_Silent_p.G449G|CACNA1A_uc010xne.1_5'UTR	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	450	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGAAGGGAGAACCTGCCAGGG	0.502													3	10					0	0	0.004672	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13928122	13928122	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:13928122C>T	uc002mxh.1	+	7	1462	c.1273C>T	c.(1273-1275)CTG>TTG	p.L425L	ZSWIM4_uc010xng.1_Silent_p.L348L	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	425							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CAGGGCGCTCCTGGAGGCCTG	0.632													20	28					0	0	0.010504	0	0
BRD4	23476	broad.mit.edu	37	19	15350808	15350809	+	Missense_Mutation	DNP	CG	GC	GC			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:15350808_15350809CG>GC	uc002nar.2	-	15	3416_3417	c.3194_3195CG>GC	c.(3193-3195)CCG>CGC	p.P1065R		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1065					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GTATCATAAGCGGGGAGGGGGC	0.564			T	NUT|C15orf55	lethal midline carcinoma of young people								6	27					0	0	0.004672	0	0
CHERP	10523	broad.mit.edu	37	19	16640618	16640618	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:16640618A>G	uc002nei.1	-	8	1044	c.970T>C	c.(970-972)TTT>CTT	p.F324L	MED26_uc002nee.2_Intron	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	324	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						CTGGTGACAAACTCCTCGTGC	0.507													8	17					0	0	0.013537	0	0
IL12RB1	3594	broad.mit.edu	37	19	18177379	18177380	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:18177379_18177380GG>AA	uc002nhw.1	-	12	1519_1520	c.1455_1456CC>TT	c.(1453-1458)TGCCGA>TGTTGA	p.R486*	IL12RB1_uc010xqb.1_Nonsense_Mutation_p.R486*|IL12RB1_uc002nhx.1_Nonsense_Mutation_p.R526*	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	486	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TCTTCATCTCGGCAGCGGACAA	0.361													18	32					0	0	0.004672	0	0
IL12RB1	3594	broad.mit.edu	37	19	18194243	18194243	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:18194243T>C	uc002nhw.1	-	2	187	c.123A>G	c.(121-123)TCA>TCG	p.S41S	IL12RB1_uc010xqb.1_Silent_p.S41S|IL12RB1_uc002nhx.1_Silent_p.S81S|IL12RB1_uc002nhy.2_Silent_p.S41S	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	41	Extracellular (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCCCCGAACCTGAGTCTGCAT	0.567													3	56					0	0	0.000602	0	0
ZNF208	7757	broad.mit.edu	37	19	22156113	22156113	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:22156113G>A	uc002nqp.2	-	5	1572	c.1423C>T	c.(1423-1425)CAT>TAT	p.H475Y	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTACAGTATGAATTTTCTTA	0.348													11	17					0	0	0.010729	0	0
MLL4	9757	broad.mit.edu	37	19	36218823	36218823	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:36218823C>T	uc010eei.2	+	19	4434	c.4434C>T	c.(4432-4434)CAC>CAT	p.H1478H		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1478					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCATGCGGCACTCGGAGGAGG	0.627													5	11					0	0	0.001168	0	0
C19orf55	148137	broad.mit.edu	37	19	36256056	36256056	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:36256056G>A	uc002obq.1	+	7	821	c.748G>A	c.(748-750)GGC>AGC	p.G250S		NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	250										ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCCAGCAAGGGCCTTGGCCC	0.398													12	18					0	0	0.010729	0	0
ZNF568	374900	broad.mit.edu	37	19	37441305	37441305	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:37441305C>T	uc002ofc.2	+	7	1765	c.1250C>T	c.(1249-1251)CCC>CTC	p.P417L	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.P341L|ZNF568_uc010efe.2_Missense_Mutation_p.P341L|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTGAGAAACCCTATGTATGT	0.388													22	27					0	0	0.003330	0	0
ZNF607	84775	broad.mit.edu	37	19	38189123	38189123	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:38189123T>C	uc002ohc.1	-	5	2505	c.1909A>G	c.(1909-1911)AGC>GGC	p.S637G	ZNF607_uc002ohb.1_Missense_Mutation_p.S636G	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	637	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GCATGAACGCTTTCATGTCTA	0.368													10	54					0	0	0.008291	0	0
ZNF573	126231	broad.mit.edu	37	19	38230580	38230580	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:38230580C>T	uc002ohe.2	-	4	833	c.811G>A	c.(811-813)GAA>AAA	p.E271K	ZNF573_uc010efs.2_Missense_Mutation_p.E184K|ZNF573_uc002ohd.2_Missense_Mutation_p.E269K|ZNF573_uc002ohf.2_Missense_Mutation_p.E213K|ZNF573_uc002ohg.2_Missense_Mutation_p.E183K	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TATGGTTTTTCGCCAGTATGA	0.428													27	44					0	0	0.006320	0	0
FCGBP	8857	broad.mit.edu	37	19	40408029	40408029	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:40408029C>T	uc002omp.3	-	9	4700	c.4692G>A	c.(4690-4692)GAG>GAA	p.E1564E		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1564	TIL 3.|Cys-rich.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACTGGCAGCCCTCAGCACACC	0.602													10	31					0	0	0.006214	0	0
BCKDHA	593	broad.mit.edu	37	19	41925134	41925134	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:41925134C>T	uc002oqq.2	+	5	608	c.579C>T	c.(577-579)GTC>GTT	p.V193V	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Silent_p.V227V|BCKDHA_uc002oqp.1_Silent_p.V85V|BCKDHA_uc002oqr.2_Silent_p.V193V|BCKDHA_uc010xvz.1_Silent_p.V171V	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	193					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						AGATGCCTGTCCACTACGGCT	0.572													10	13					0	0	0.006214	0	0
CD79A	973	broad.mit.edu	37	19	42381431	42381431	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:42381431C>T	uc002orv.2	+	1	242	c.57C>T	c.(55-57)TTC>TTT	p.F19F	CD79A_uc002oru.2_Silent_p.F19F	NM_001783	NP_001774	P11912	CD79A_HUMAN	CD79A antigen isoform 1 precursor	19					B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			ovary(2)|pancreas(1)	3						TCCTCCTCTTCCTGCTGTCTG	0.607			O|S		DLBCL								22	26					0	0	0.003954	0	0
ATP1A3	478	broad.mit.edu	37	19	42485885	42485885	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:42485885G>A	uc002osg.2	-	10	1445	c.1291C>T	c.(1291-1293)CCT>TCT	p.P431S	ATP1A3_uc010xwf.1_Missense_Mutation_p.P442S|ATP1A3_uc010xwg.1_Missense_Mutation_p.P401S|ATP1A3_uc010xwh.1_Missense_Mutation_p.P444S|ATP1A3_uc002osh.2_Missense_Mutation_p.P431S	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	431	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TTGAGCACAGGGATGTTGTCC	0.592													6	21					0	0	0.001984	0	0
POU2F2	5452	broad.mit.edu	37	19	42603707	42603707	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:42603707G>A	uc002osp.2	-	7	540	c.473C>T	c.(472-474)TCC>TTC	p.S158F	POU2F2_uc002osn.2_Missense_Mutation_p.S158F|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Missense_Mutation_p.S158F|POU2F2_uc002osr.1_Missense_Mutation_p.S158F	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	158					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				CCGGGGCTGGGAGGTCAGAAG	0.602													9	24					0	0	0.010729	0	0
PSG3	5671	broad.mit.edu	37	19	43237165	43237165	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:43237165C>T	uc002oue.2	-	3	612	c.480G>A	c.(478-480)GAG>GAA	p.E160E	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Silent_p.E182E	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	160	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				CCTCCATGTCCTCCCTGGGGT	0.542													50	97					0	0	0.014410	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028047	45028047	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:45028047C>T	uc010ejn.1	-	3	460	c.444G>A	c.(442-444)AGG>AGA	p.R148R	CEACAM20_uc010ejo.1_Silent_p.R148R|CEACAM20_uc010ejp.1_Silent_p.R148R|CEACAM20_uc010ejq.1_Silent_p.R148R	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	148	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				TGGGGTCGCTCCTCTGGCTCA	0.443													80	107					0	0	0.014410	0	0
BCAM	4059	broad.mit.edu	37	19	45322970	45322970	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:45322970G>A	uc002ozu.2	+	13	1794	c.1750G>A	c.(1750-1752)GAG>AAG	p.E584K	BCAM_uc002ozt.1_Missense_Mutation_p.E584K	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	584	Cytoplasmic (Potential).				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CCAGCGGCGGGAGAAGGGGGC	0.493													22	46					0	0	0.004656	0	0
CLPTM1	1209	broad.mit.edu	37	19	45476417	45476417	+	Nonsense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:45476417G>T	uc002pai.2	+	3	274	c.259G>T	c.(259-261)GGA>TGA	p.G87*	CLPTM1_uc010ejv.1_Translation_Start_Site|CLPTM1_uc010xxf.1_Translation_Start_Site|CLPTM1_uc010xxg.1_Nonsense_Mutation_p.G73*	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	87	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GGGCCCCGGAGGAGCTCCACG	0.632													68	96					1.4533e-46	4.69114e-46	0.014410	1	0
SIGLEC7	27036	broad.mit.edu	37	19	51645918	51645918	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:51645918C>T	uc002pvv.1	+	1	361	c.292C>T	c.(292-294)CTT>TTT	p.L98F	SIGLEC7_uc002pvw.1_Missense_Mutation_p.L98F|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Missense_Mutation_p.L98F	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	98	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		ATTCCACCTCCTTGGGGACCC	0.517													20	54					0	0	0.012319	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986533	51986533	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:51986533G>A	uc002pwv.1	+	5	1119	c.1119G>A	c.(1117-1119)AGG>AGA	p.R373R		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	373	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGACGTCAGGATCCAGGCCC	0.597													9	20					0	0	0.004482	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52714670	52714670	+	Missense_Mutation	SNP	C	T	T	rs112759633		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:52714670C>T	uc002pyp.2	+	4	587	c.428C>T	c.(427-429)TCC>TTC	p.S143F	PPP2R1A_uc010ydk.1_Missense_Mutation_p.S88F|PPP2R1A_uc010epm.1_Missense_Mutation_p.S183F|PPP2R1A_uc002pyq.2_5'UTR	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	143	PP2A subunit B binding.|SV40 small T antigen binding.|HEAT 4.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGGTTCACCTCCCGCACCTCG	0.642			Mis		clear cell ovarian carcinoma								16	31					0	0	0.004007	0	0
ZNF578	147660	broad.mit.edu	37	19	53007995	53007995	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:53007995G>A	uc002pzp.3	+	5	395	c.151G>A	c.(151-153)GAA>AAA	p.E51K		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:Variant_position_missing_in_Q96N58_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTTGTACAGGGAAGTGATGTT	0.498													40	45					0	0	0.006999	0	0
LILRB3	11025	broad.mit.edu	37	19	54746055	54746055	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:54746055G>A	uc010erh.1	-	3	326	c.202C>T	c.(202-204)CCC>TCC	p.P68S	LILRA6_uc002qew.1_Missense_Mutation_p.P68S|LILRB3_uc002qeh.1_Missense_Mutation_p.P68S|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Missense_Mutation_p.P68S|LILRA6_uc002qek.1_Missense_Mutation_p.P68S|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Missense_Mutation_p.P68S|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Missense_Mutation_p.P68S|LILRB3_uc002qep.1_Missense_Mutation_p.P68S|LILRB3_uc002qeq.1_Missense_Mutation_p.P68S|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.P68S|LILRA6_uc010yep.1_Missense_Mutation_p.P68S|LILRA6_uc010yeq.1_Missense_Mutation_p.P68S|LILRA6_uc002qet.3_RNA|LILRA6_uc002qeu.1_Missense_Mutation_p.P68S|LILRA6_uc002qev.1_5'Flank	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	68	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGTCCAAGGGCTCTGGGCTT	0.572													7	169					0	0	0.001855	0	0
LILRB2	10288	broad.mit.edu	37	19	54782706	54782706	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:54782706A>C	uc002qfb.2	-	6	1182	c.916T>G	c.(916-918)TGC>GGC	p.C306G	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.C306G|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.C306G|LILRB2_uc010yet.1_Missense_Mutation_p.C190G|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	306	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGCCGAGCACTCAGAGGAG	0.662													10	15					0	0	0.010729	0	0
LILRA3	11026	broad.mit.edu	37	19	54803596	54803596	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:54803596C>T	uc002qfd.2	-	3	293	c.228G>A	c.(226-228)GAG>GAA	p.E76E	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.E76E	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	76	Ig-like C2-type 1.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTTCACAAGCTCCTGTGGGA	0.537													20	13					0	0	0.012319	0	0
KIR3DX1	90011	broad.mit.edu	37	19	55045004	55045005	+	RNA	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:55045004_55045005GG>AA	uc010yfa.1	+	3		c.230_231GG>AA			KIR3DX1_uc010yfb.1_RNA|KIR3DX1_uc010yfc.1_RNA|KIR3DX1_uc010yfd.1_RNA	NR_026716				Homo sapiens mRNA for FLJ00060 protein, partial cds.											ovary(1)	1				GBM - Glioblastoma multiforme(193;0.099)		GGTTCCCCTAGGAGGACGTGTG	0.554													9	36					0	0	0.004672	0	0
LILRB1	10859	broad.mit.edu	37	19	55144201	55144201	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:55144201C>T	uc002qgj.2	+	7	1288	c.948C>T	c.(946-948)ATC>ATT	p.I316I	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.I316I|LILRB1_uc002qgk.2_Silent_p.I316I|LILRB1_uc002qgm.2_Silent_p.I316I|LILRB1_uc010erq.2_Silent_p.I316I|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	316	Ig-like C2-type 4.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CCCTGGACATCCTGATCGCAG	0.682										HNSCC(37;0.09)			8	28					0	0	0.008291	0	0
NLRP7	199713	broad.mit.edu	37	19	55447766	55447766	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:55447766C>T	uc002qih.3	-	6	2239	c.2163G>A	c.(2161-2163)CGG>CGA	p.R721R	NLRP7_uc002qig.3_Silent_p.R693R|NLRP7_uc002qii.3_Silent_p.R721R|NLRP7_uc010esk.2_Silent_p.R721R|NLRP7_uc010esl.2_Silent_p.R749R	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	721			R -> W (in HYDM).				ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GACAGAAGTCCCGGTACGCGG	0.507													39	34					0	0	0.008740	0	0
NLRP7	199713	broad.mit.edu	37	19	55452870	55452870	+	Silent	SNP	C	T	T	rs111764628		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:55452870C>T	uc002qih.3	-	2	286	c.210G>A	c.(208-210)GCG>GCA	p.A70A	NLRP7_uc002qig.3_Silent_p.A70A|NLRP7_uc002qii.3_Silent_p.A70A|NLRP7_uc010esk.2_Silent_p.A70A|NLRP7_uc010esl.2_Silent_p.A98A	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	70	DAPIN.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGTTCACAGTCGCATTCCTTA	0.463													28	63					0	0	0.007291	0	0
NLRP9	338321	broad.mit.edu	37	19	56244857	56244857	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:56244857C>T	uc002qly.2	-	2	368	c.340G>A	c.(340-342)GAA>AAA	p.E114K		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	114						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGACAGGTTTCCTTCTCCCAT	0.378													29	63					0	0	0.003755	0	0
NLRP11	204801	broad.mit.edu	37	19	56297047	56297047	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:56297047G>A	uc010ygf.1	-	12	3757	c.3046C>T	c.(3046-3048)CCC>TCC	p.P1016S	NLRP11_uc002qlz.2_Missense_Mutation_p.P863S|NLRP11_uc002qmb.2_Missense_Mutation_p.P917S|NLRP11_uc002qmc.2_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	1016							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GACATTCTGGGAAATTTGAAA	0.373													23	56					0	0	0.003330	0	0
NLRP13	126204	broad.mit.edu	37	19	56443625	56443625	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:56443625A>C	uc010ygg.1	-	1	78	c.53T>G	c.(52-54)CTG>CGG	p.L18R		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	18	DAPIN.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CAGGTAAGGCAGAAGCCCTTG	0.532													11	25					0	0	0.013537	0	0
ZNF470	388566	broad.mit.edu	37	19	57088460	57088460	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr19:57088460C>T	uc002qnl.3	+	6	1339	c.663C>T	c.(661-663)GAC>GAT	p.D221D	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D221G(1)		ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		ACAAGCAAGACCGTGGAGAAA	0.308													18	29					0	0	0.008871	0	0
RRM2	6241	broad.mit.edu	37	2	10267090	10267090	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:10267090A>C	uc002rah.2	+	6	849	c.658A>C	c.(658-660)ACC>CCC	p.T220P		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	220					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CAAAGAGGCTACCTATGGTAA	0.458													17	59					0	0	0.006122	0	0
APOB	338	broad.mit.edu	37	2	21241968	21241968	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:21241968C>T	uc002red.2	-	20	3145	c.3017G>A	c.(3016-3018)AGG>AAG	p.R1006K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1006					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCTGTAGGCCTCAGTTCCAG	0.438													114	179					0	0	0.014410	0	0
HADHA	3030	broad.mit.edu	37	2	26462009	26462009	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:26462009A>C	uc002rgy.2	-	2	200	c.70T>G	c.(70-72)TAT>GAT	p.Y24D	HADHA_uc010yks.1_5'UTR|HADHA_uc010ykt.1_5'UTR	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	24					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	CGGCATATATAACCTGTAAGA	0.274													55	114					0	0	0.014410	0	0
OTOF	9381	broad.mit.edu	37	2	26705273	26705274	+	Splice_Site	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:26705273_26705274CC>TT	uc002rhk.2	-	14	1706	c.1579_splice	c.e14+1	p.G527_splice		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a						cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCTGCTGACCTTTGTCTCCG	0.574													11	22					0	0	0.004672	0	0
RBKS	64080	broad.mit.edu	37	2	28113191	28113192	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:28113191_28113192GG>AA	uc002rlo.1	-	1	32_33	c.21_22CC>TT	c.(19-24)CCCCAG>CCTTAG	p.Q8*	BRE_uc002rlp.1_5'Flank|BRE_uc002rlq.2_5'Flank|BRE_uc002rlr.2_5'Flank|BRE_uc002rls.2_5'Flank|BRE_uc002rlt.2_5'Flank|BRE_uc002rlu.2_5'Flank|RBKS_uc010ezi.1_5'UTR|RBKS_uc010ymg.1_Nonsense_Mutation_p.Q8*|LOC100302650_uc010ymh.1_RNA	NM_022128	NP_071411	Q9H477	RBSK_HUMAN	ribokinase	8					D-ribose metabolic process		ATP binding|ribokinase activity			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					CACTGCCTCTGGGGTTCCCCAG	0.649													7	13					0	0	0.004672	0	0
PLB1	151056	broad.mit.edu	37	2	28719005	28719005	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:28719005C>T	uc002rmb.1	+	1	24	c.24C>T	c.(22-24)TTC>TTT	p.F8F	PLB1_uc010ezj.1_Silent_p.F8F	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	8					lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					CAGGCATTTTCCTCCTGGAGC	0.597													23	44					0	0	0.005443	0	0
GALNT14	79623	broad.mit.edu	37	2	31178493	31178493	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:31178493C>T	uc002rnr.2	-	6	1264	c.645G>A	c.(643-645)AGG>AGA	p.R215R	GALNT14_uc002rnq.2_Silent_p.R195R|GALNT14_uc002rns.2_Silent_p.R220R|GALNT14_uc010ymr.1_Silent_p.R180R|GALNT14_uc010ezo.1_Silent_p.R182R|GALNT14_uc010ezp.1_Silent_p.R186R	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	215	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					CCTCTTTGACCCTGTGCAACA	0.612													14	34					0	0	0.004007	0	0
SOS1	6654	broad.mit.edu	37	2	39240630	39240630	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:39240630C>A	uc002rrk.3	-	13	2179	c.2138G>T	c.(2137-2139)CGA>CTA	p.R713L	SOS1_uc002rrj.3_Missense_Mutation_p.R327L	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	713	N-terminal Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TTCTTCCATTCGTTGCAAAAG	0.333									Noonan_syndrome				36	93					7.61001e-30	2.44947e-29	0.005524	1	0
THADA	63892	broad.mit.edu	37	2	43802077	43802078	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:43802077_43802078GG>TT	uc002rsw.3	-	11	1478_1479	c.1126_1127CC>AA	c.(1126-1128)CCG>AAG	p.P376K	THADA_uc002rsx.3_Missense_Mutation_p.P376K|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.P86K|THADA_uc002rta.2_Missense_Mutation_p.P86K|THADA_uc002rtb.1_Missense_Mutation_p.P376K|THADA_uc002rtc.3_Missense_Mutation_p.P376K|THADA_uc002rtd.2_Missense_Mutation_p.P376K	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	376							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CGTTAGGCTCGGGGAACTTGAT	0.426													14	488					0	0	0.004672	0	0
CCDC88A	55704	broad.mit.edu	37	2	55566693	55566693	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:55566693G>A	uc002ryv.2	-	13	2267	c.1425C>T	c.(1423-1425)ACC>ACT	p.T475T	CCDC88A_uc010yoz.1_Silent_p.T475T|CCDC88A_uc010ypa.1_Silent_p.T475T|CCDC88A_uc010ypb.1_Silent_p.T377T	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	475	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GCTCTTCTACGGTTTTTGTCA	0.378													15	42					0	0	0.002450	0	0
ZNF638	27332	broad.mit.edu	37	2	71591243	71591243	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:71591243C>T	uc002shx.2	+	5	1897	c.1578C>T	c.(1576-1578)TGC>TGT	p.C526C	ZNF638_uc010fec.2_Silent_p.C632C|ZNF638_uc010yqw.1_Silent_p.C105C|ZNF638_uc002shw.2_Silent_p.C526C|ZNF638_uc002shy.2_Silent_p.C526C|ZNF638_uc002shz.2_Silent_p.C526C|ZNF638_uc002sia.2_Silent_p.C526C|ZNF638_uc002sib.1_Silent_p.C526C|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	526	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						CAAGAATTTGCCATCGTTTCA	0.428													22	33					0	0	0.012319	0	0
ALMS1	7840	broad.mit.edu	37	2	73784358	73784358	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:73784358C>T	uc002sje.1	+	16	10204	c.10093C>T	c.(10093-10095)CAA>TAA	p.Q3365*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.Q3321*|ALMS1_uc002sjg.2_Nonsense_Mutation_p.Q2751*|ALMS1_uc002sjh.1_Nonsense_Mutation_p.Q2751*|ALMS1_uc010fev.1_Nonsense_Mutation_p.Q123*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3363					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGCCTCAGTTCAAGTGCTAAT	0.413													26	37					0	0	0.004656	0	0
C2orf78	388960	broad.mit.edu	37	2	74042413	74042413	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:74042413G>A	uc002sjr.1	+	3	1184	c.1063G>A	c.(1063-1065)GAA>AAA	p.E355K		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	355										ovary(2)	2						TCCAAGCCAGGAAAAAAATGA	0.428													17	31					0	0	0.010504	0	0
ANKRD36	375248	broad.mit.edu	37	2	97881266	97881266	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:97881266C>T	uc010yva.1	+	62	3949	c.3705C>T	c.(3703-3705)TTC>TTT	p.F1235F	ANKRD36_uc002sxr.1_Intron	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1235											0						ATGTAATGTTCGATCAAATAG	0.318													6	15					0	0	0.004482	0	0
TSGA10	80705	broad.mit.edu	37	2	99695239	99695239	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:99695239T>G	uc002szg.3	-	10	1393	c.765A>C	c.(763-765)GAA>GAC	p.E255D	TSGA10_uc002szh.3_Missense_Mutation_p.E255D|TSGA10_uc002szi.3_Missense_Mutation_p.E255D|TSGA10_uc010fin.1_Missense_Mutation_p.E255D|TSGA10_uc010yvn.1_Missense_Mutation_p.E255D	NM_182911	NP_878915	Q9BZW7	TSG10_HUMAN	testis specific, 10	255					spermatogenesis	cytoplasm|nuclear membrane				ovary(1)|central_nervous_system(1)	2						GAATGCTGATTTCTTCTCGCT	0.338													6	46					0	0	0.001168	0	0
CHST10	9486	broad.mit.edu	37	2	101010059	101010059	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:101010059A>G	uc002tam.2	-	7	1078	c.719T>C	c.(718-720)TTC>TCC	p.F240S		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	240	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						GTAGCGCACGAAATCTTCAAA	0.542													49	91					0	0	0.014410	0	0
C2orf40	84417	broad.mit.edu	37	2	106694293	106694293	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:106694293C>T	uc010fjf.2	+	4	466	c.358C>T	c.(358-360)CAA>TAA	p.Q120*		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	120						extracellular region|transport vesicle					0						CGATTACTACCAACGTCACTA	0.453													22	42					0	0	0.014323	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107450539	107450539	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:107450539C>T	uc002tdq.2	-	3	1126	c.1007G>A	c.(1006-1008)GGG>GAG	p.G336E	ST6GAL2_uc002tdr.2_Missense_Mutation_p.G336E|ST6GAL2_uc002tds.3_Missense_Mutation_p.G336E	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	336	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GGTTTTATTCCCAACATCTTT	0.388													52	87					0	0	0.014410	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:114355998C>G	uc002tkh.2	+	5	674	c.616C>G	c.(616-618)CAC>GAC	p.H206D	WASH2P_uc002tka.2_RNA|WASH2P_uc002tkb.2_RNA|WASH2P_uc002tkd.2_RNA	NM_182905	NP_878908			WAS protein family homolog 1												0						CCAAGGTGGGCACTTGATGTC	0.612													2	7					0	0	0.004672	0	0
GLI2	2736	broad.mit.edu	37	2	121726354	121726354	+	Silent	SNP	C	T	T	rs142322049		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:121726354C>T	uc010flp.2	+	5	738	c.708C>T	c.(706-708)TCC>TCT	p.S236S	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Missense_Mutation_p.P107S|GLI2_uc010flo.1_Silent_p.S111S|GLI2_uc002tmw.1_Silent_p.S236S	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	236					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				TGTCCATCTCCCCACTCTCAG	0.637													26	41					0	0	0.006320	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261885	125261885	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:125261885C>T	uc002tno.2	+	8	1440	c.1076C>T	c.(1075-1077)TCC>TTC	p.S359F	CNTNAP5_uc010flu.2_Missense_Mutation_p.S360F	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	359	Laminin G-like 1.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GTCACTTTTTCCTGCTCCGAA	0.463													21	48					0	0	0.002780	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125367418	125367418	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:125367418G>A	uc002tno.2	+	12	2158	c.1794G>A	c.(1792-1794)GGG>GGA	p.G598G	CNTNAP5_uc010flu.2_Silent_p.G599G	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	598	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGCACCAGGGGAATACAGCCG	0.537													16	32					0	0	0.003163	0	0
NCKAP5	344148	broad.mit.edu	37	2	133486512	133486512	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:133486512G>A	uc002ttp.2	-	18	5831	c.5457C>T	c.(5455-5457)TCC>TCT	p.S1819S	NCKAP5_uc002ttq.2_Silent_p.S500S	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1819							protein binding				0						TCTGCTTTTGGGAACTGACTT	0.478													84	155					0	0	0.014410	0	0
THSD7B	80731	broad.mit.edu	37	2	137988738	137988738	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:137988738C>T	uc002tva.1	+	7	1755	c.1755C>T	c.(1753-1755)TCC>TCT	p.S585S	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.S475S	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTTCCCAGTCCTGTTCAAATA	0.507													14	14					0	0	0.002450	0	0
LRP1B	53353	broad.mit.edu	37	2	141072529	141072529	+	Silent	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:141072529T>G	uc002tvj.1	-	83	13752	c.12780A>C	c.(12778-12780)GGA>GGC	p.G4260G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4260	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGCAAGTTCCTCCATTCTGGC	0.363										TSP Lung(27;0.18)			13	36					0	0	0.002450	0	0
LRP1B	53353	broad.mit.edu	37	2	141081480	141081480	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:141081480G>A	uc002tvj.1	-	81	13468	c.12496C>T	c.(12496-12498)CGT>TGT	p.R4166C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4166	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTTTATAACGATGAGATATC	0.244										TSP Lung(27;0.18)			27	68					0	0	0.006320	0	0
NEB	4703	broad.mit.edu	37	2	152496875	152496875	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:152496875C>T	uc010fnx.2	-	61	8870	c.8679G>A	c.(8677-8679)CAG>CAA	p.Q2893Q	NEB_uc002txu.2_5'Flank	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2893	Nebulin 78.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACATCGCTCTGGAGGTCAT	0.517													20	52					0	0	0.010504	0	0
CACNB4	785	broad.mit.edu	37	2	152711872	152711872	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:152711872T>G	uc002tya.2	-	11	954	c.886A>C	c.(886-888)ATT>CTT	p.I296L	CACNB4_uc002txy.2_Missense_Mutation_p.I262L|CACNB4_uc002txz.2_Missense_Mutation_p.I278L|CACNB4_uc010fnz.2_Missense_Mutation_p.I296L	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	296					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	ATTCTTTCAATTTCACTTTGT	0.333													14	21					0	0	0.001855	0	0
ACVR1C	130399	broad.mit.edu	37	2	158412824	158412824	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:158412824G>A	uc002tzk.3	-	3	568	c.325C>T	c.(325-327)CTT>TTT	p.L109F	ACVR1C_uc002tzl.3_Intron|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Missense_Mutation_p.L59F	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	109	Extracellular (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						ATGGGTCCAAGTTTTGGGGCA	0.438													17	36					0	0	0.008871	0	0
SCN3A	6328	broad.mit.edu	37	2	165984373	165984373	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:165984373C>T	uc002ucx.2	-	18	3653	c.3161G>A	c.(3160-3162)GGA>GAA	p.G1054E	SCN3A_uc002ucy.2_Missense_Mutation_p.G1005E|SCN3A_uc002ucz.2_Missense_Mutation_p.G1005E|SCN3A_uc002uda.1_Missense_Mutation_p.G874E|SCN3A_uc002udb.1_Missense_Mutation_p.G874E	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1054						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TATTTCAATTCCAGTATTATT	0.373													38	46					0	0	0.004289	0	0
CSRNP3	80034	broad.mit.edu	37	2	166535361	166535361	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:166535361C>T	uc002udf.2	+	7	1232	c.856C>T	c.(856-858)CCC>TCC	p.P286S	CSRNP3_uc002udg.2_Missense_Mutation_p.P286S	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	286					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						GCAGCAAATCCCCACGCTGAA	0.448													26	29					0	0	0.004656	0	0
XIRP2	129446	broad.mit.edu	37	2	168100212	168100212	+	Silent	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:168100212A>C	uc002udx.2	+	8	2328	c.2310A>C	c.(2308-2310)GCA>GCC	p.A770A	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.A595A|XIRP2_uc010fpq.2_Silent_p.A548A|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	595	Xin 7.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TAAGAACAGCACGGTGGATGT	0.383													21	30					0	0	0.012319	0	0
PDE11A	50940	broad.mit.edu	37	2	178936519	178936519	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:178936519G>A	uc002ulq.2	-	1	964	c.646C>T	c.(646-648)CTT>TTT	p.L216F	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	216					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GTGAGGTCAAGGTCATTGGAG	0.502									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				29	58					0	0	0.013726	0	0
TTN	7273	broad.mit.edu	37	2	179402191	179402191	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:179402191G>T	uc010zfg.1	-	304	92263	c.92039C>A	c.(92038-92040)ACT>AAT	p.T30680N	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T24375N|TTN_uc010zfi.1_Missense_Mutation_p.T24308N|TTN_uc010zfj.1_Missense_Mutation_p.T24183N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31607							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGTGCTCAGTGTTTTCAAT	0.413													8	24					0.000274275	0.000865609	0.004482	1	0
TTN	7273	broad.mit.edu	37	2	179462310	179462310	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:179462310T>G	uc010zfg.1	-	243	50019	c.49795A>C	c.(49795-49797)AAT>CAT	p.N16599H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N10294H|TTN_uc010zfi.1_Missense_Mutation_p.N10227H|TTN_uc010zfj.1_Missense_Mutation_p.N10102H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17526							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCGGCTTCATTTTTGGCAAGA	0.383													21	34					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179500945	179500945	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:179500945T>C	uc010zfg.1	-	175	33873	c.33649A>G	c.(33649-33651)ACA>GCA	p.T11217A	TTN_uc010zfh.1_Missense_Mutation_p.T4912A|TTN_uc010zfi.1_Missense_Mutation_p.T4845A|TTN_uc010zfj.1_Missense_Mutation_p.T4720A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12144							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCCAGTGTTTTTACAAAA	0.373													12	11					0	0	0.013537	0	0
TTN	7273	broad.mit.edu	37	2	179647676	179647676	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:179647676G>A	uc010zfg.1	-	18	3181	c.2957C>T	c.(2956-2958)TCC>TTC	p.S986F	TTN_uc010zfh.1_Missense_Mutation_p.S940F|TTN_uc010zfi.1_Missense_Mutation_p.S940F|TTN_uc010zfj.1_Missense_Mutation_p.S940F|TTN_uc002unb.2_Missense_Mutation_p.S986F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	986							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGTCAATGGAACTTTCGAT	0.473													23	39					0	0	0.004656	0	0
PPP1R1C	151242	broad.mit.edu	37	2	182850861	182850861	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:182850861G>A	uc002uoo.2	+	1	311	c.24G>A	c.(22-24)AAG>AAA	p.K8K	PPP1R1C_uc002uon.2_Intron|PPP1R1C_uc002uop.1_Silent_p.K8K|PPP1R1C_uc010frm.1_Silent_p.K8K|PPP1R1C_uc010frn.1_RNA	NM_001080545	NP_001074014	Q8WVI7	PPR1C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	8					signal transduction	cytoplasm	protein phosphatase inhibitor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0628)			GTCCCAAAAAGATACAGTTTG	0.448													36	68					0	0	0.011902	0	0
MAP2	4133	broad.mit.edu	37	2	210560314	210560314	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:210560314C>T	uc002vde.1	+	7	3668	c.3420C>T	c.(3418-3420)CTC>CTT	p.L1140L	MAP2_uc002vdc.1_Silent_p.L1140L|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.L1136L	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1140					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATGAAAGTCTCACCATGGAGT	0.463													23	14					0	0	0.003330	0	0
ATIC	471	broad.mit.edu	37	2	216213859	216213859	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:216213859C>T	uc002vex.3	+	15	1720	c.1546C>T	c.(1546-1548)CCT>TCT	p.P516S	ATIC_uc010zjo.1_Missense_Mutation_p.P457S|ATIC_uc002vey.3_Missense_Mutation_p.P515S	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	516					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	TGAGGAAGTCCCTGAGTTACT	0.448			T	ALK	ALCL								43	47					0	0	0.014410	0	0
FAM124B	79843	broad.mit.edu	37	2	225266082	225266082	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:225266082G>A	uc002vnx.2	-	1	630	c.404C>T	c.(403-405)TCC>TTC	p.S135F	FAM124B_uc002vnw.2_Missense_Mutation_p.S135F	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	135							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		CAGGATCTCGGAGCCACAGTG	0.537													20	26					0	0	0.012319	0	0
COL4A3	1285	broad.mit.edu	37	2	228172560	228172560	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:228172560G>A	uc002vom.1	+	48	4549	c.4387G>A	c.(4387-4389)GGG>AGG	p.G1463R	COL4A3_uc002von.1_Missense_Mutation_p.G1463R|COL4A3_uc002voo.1_Missense_Mutation_p.G1463R|COL4A3_uc002vop.1_Intron|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'UTR	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1463	Collagen IV NC1.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		ATGTCCAGAGGGGACAGTGCC	0.502													19	41					0	0	0.010504	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881545	228881545	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:228881545G>A	uc002vpq.2	-	7	4072	c.4025C>T	c.(4024-4026)TCG>TTG	p.S1342L	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1342L|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1342L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1342						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCTGCTTGCGAGGGAGAGCC	0.522													16	31					0	0	0.003163	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884134	228884134	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:228884134G>A	uc002vpq.2	-	7	1483	c.1436C>T	c.(1435-1437)ACC>ATC	p.T479I	SPHKAP_uc002vpp.2_Missense_Mutation_p.T479I|SPHKAP_uc010zlx.1_Missense_Mutation_p.T479I	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	479						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GATGCTTGAGGTTTCAACAGA	0.532													13	35					0	0	0.013537	0	0
ALPP	250	broad.mit.edu	37	2	233244608	233244608	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:233244608G>A	uc002vsq.2	+	5	784	c.619G>A	c.(619-621)GAC>AAC	p.D207N	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	207						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GGGGTGCCAGGACATCGCTAC	0.682													17	41					0	0	0.007413	0	0
IQCA1	79781	broad.mit.edu	37	2	237276886	237276886	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:237276886G>A	uc002vvz.1	-	14	1802	c.1620C>T	c.(1618-1620)TCC>TCT	p.S540S	IQCA1_uc002vwb.2_Silent_p.S548S|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Silent_p.S499S	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	540							ATP binding			ovary(1)	1						CATCCAGGAGGGAGGGCATGG	0.517													4	7					0	0	0.000602	0	0
OR6B2	389090	broad.mit.edu	37	2	240969565	240969565	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:240969565G>A	uc002vyr.2	-	2	328	c.282C>T	c.(280-282)TTC>TTT	p.F94F	OR6B2_uc010zoc.1_Silent_p.F94F	NM_001005853	NP_001005853	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TGCACCCGACGAAAGAGATGC	0.572													11	21					0	0	0.002450	0	0
AGXT	189	broad.mit.edu	37	2	241808652	241808652	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr2:241808652C>T	uc002waa.3	+	2	352	c.231C>T	c.(229-231)GTC>GTT	p.V77V	AGXT_uc010zoi.1_Silent_p.V77V	NM_000030	NP_000021	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	77					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity				0		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TCACACTGGTCATCTCTGGCT	0.607													20	36					0	0	0.002780	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3679968	3679968	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:3679968G>A	uc002wja.2	-	7	1667	c.1667C>T	c.(1666-1668)CCC>CTC	p.P556L	SIGLEC1_uc002wiz.3_Missense_Mutation_p.P556L	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	556	Ig-like C2-type 5.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						GCTGCTGCCGGGACCCTCGTG	0.677													5	6					0	0	0.000602	0	0
PROKR2	128674	broad.mit.edu	37	20	5283294	5283294	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:5283294G>A	uc010zqw.1	-	2	547	c.547C>T	c.(547-549)CTC>TTC	p.L183F	PROKR2_uc010zqx.1_Missense_Mutation_p.L183F|PROKR2_uc010zqy.1_Missense_Mutation_p.L183F	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	183	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ATGGCAATGAGAATGGACACC	0.512										HNSCC(71;0.22)			39	87					0	0	0.011902	0	0
PAK7	57144	broad.mit.edu	37	20	9547011	9547011	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:9547011C>T	uc002wnl.2	-	6	1556	c.1011G>A	c.(1009-1011)CAG>CAA	p.Q337Q	PAK7_uc002wnk.2_Silent_p.Q337Q|PAK7_uc002wnj.2_Silent_p.Q337Q|PAK7_uc010gby.1_Silent_p.Q337Q	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	337	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGAGGACCATCTGTGCTCGAT	0.532													39	55					0	0	0.008740	0	0
ASXL1	171023	broad.mit.edu	37	20	31024516	31024516	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:31024516C>T	uc002wxs.2	+	12	4427	c.4001C>T	c.(4000-4002)CCC>CTC	p.P1334L	ASXL1_uc010geb.2_Missense_Mutation_p.P1225L	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1334					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CCAGTTTTTCCCAGTGGGAAG	0.577			F|N|Mis		MDS|CMML								17	24					0	0	0.004990	0	0
CEP250	11190	broad.mit.edu	37	20	34091156	34091156	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:34091156C>T	uc002xcm.2	+	31	5630	c.4959C>T	c.(4957-4959)CTC>CTT	p.L1653L	CEP250_uc010zve.1_Silent_p.L1021L	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1653	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTCAGGATCTCGAGAGGAGAG	0.567													41	77					0	0	0.009718	0	0
ROMO1	140823	broad.mit.edu	37	20	34288725	34288725	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:34288725G>T	uc002xdy.2	+	3	284	c.137G>T	c.(136-138)GGA>GTA	p.G46V	NFS1_uc002xdt.1_5'Flank|NFS1_uc002xdu.1_5'Flank|NFS1_uc002xdv.1_5'Flank|NFS1_uc010zvk.1_5'Flank|NFS1_uc010zvl.1_5'Flank|NFS1_uc002xdw.1_5'Flank|NFS1_uc002xdx.2_5'Flank|ROMO1_uc010gfm.2_Missense_Mutation_p.G46V	NM_080748	NP_542786	P60602	ROMO1_HUMAN	reactive oxygen species modulator 1	46					cellular response to reactive oxygen species|positive regulation of cell proliferation|positive regulation of reactive oxygen species metabolic process|replicative cell aging	integral to membrane|mitochondrial membrane					0						CTCAGGATCGGAATGCGGGGT	0.483													17	56					9.16793e-09	2.91368e-08	0.004990	1	0
KIAA1755	85449	broad.mit.edu	37	20	36867950	36867950	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:36867950G>A	uc002xhy.1	-	4	1999	c.1727C>T	c.(1726-1728)TCC>TTC	p.S576F	KIAA1755_uc002xhz.1_Missense_Mutation_p.S576F	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	576										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TGCTATCCTGGAGCGGAAAAC	0.637													11	25					0	0	0.001855	0	0
PTPRT	11122	broad.mit.edu	37	20	40733337	40733337	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:40733337C>T	uc002xkg.2	-	25	3596	c.3412G>A	c.(3412-3414)GAT>AAT	p.D1138N	PTPRT_uc010ggj.2_Missense_Mutation_p.D1157N|PTPRT_uc010ggi.2_Missense_Mutation_p.D341N	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1138	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGATGGCATCGTGCACAAAC	0.512													17	27					0	0	0.004990	0	0
PTPRT	11122	broad.mit.edu	37	20	40748607	40748607	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:40748607T>C	uc002xkg.2	-	20	3036	c.2852A>G	c.(2851-2853)TAC>TGC	p.Y951C	PTPRT_uc010ggj.2_Missense_Mutation_p.Y970C|PTPRT_uc010ggi.2_Missense_Mutation_p.Y154C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	951	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGTCGATGGTATCCCTGGAT	0.438													5	81					0	0	0.001168	0	0
TOX2	84969	broad.mit.edu	37	20	42695394	42695394	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:42695394C>T	uc002xlf.3	+	7	1344	c.1327C>T	c.(1327-1329)CCC>TCC	p.P443S	TOX2_uc010ggo.2_Missense_Mutation_p.P461S|TOX2_uc002xle.3_Missense_Mutation_p.P419S|TOX2_uc010ggp.2_Missense_Mutation_p.P419S|TOX2_uc002xlg.2_Missense_Mutation_p.P260S|TOX2_uc010zwk.1_Missense_Mutation_p.P339S	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	443	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTCTGAGTTCCCCAGCAGCTC	0.647													24	43					0	0	0.005443	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870703	51870703	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:51870703G>A	uc002xwo.2	+	2	1662	c.706G>A	c.(706-708)GAA>AAA	p.E236K		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	236	C2H2-type 1.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GCACATGAATGAAACGGGCCA	0.532													16	23					0	0	0.004007	0	0
PCK1	5105	broad.mit.edu	37	20	56138761	56138761	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:56138761C>T	uc002xyn.3	+	6	1102	c.939C>T	c.(937-939)GCC>GCT	p.A313A	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	313					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ATGACATTGCCTGGATGAAGT	0.557													25	48					0	0	0.004656	0	0
ZBP1	81030	broad.mit.edu	37	20	56185226	56185227	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:56185226_56185227CC>TT	uc002xyo.2	-	7	1352_1353	c.1071_1072GG>AA	c.(1069-1074)GAGGGG>GAAAGG	p.G358R	ZBP1_uc010gjm.2_Missense_Mutation_p.G357R|ZBP1_uc002xyp.2_Missense_Mutation_p.G283R	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	358						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CCTGGCTCCCCCTCTCCAGACC	0.584													19	64					0	0	0.004672	0	0
GNAS	2778	broad.mit.edu	37	20	57428691	57428691	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:57428691C>T	uc002xzw.2	+	1	656	c.371C>T	c.(370-372)CCC>CTC	p.P124L	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCTGGATTCCCCAGTGGGGTC	0.632			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			12	28					0	0	0.002450	0	0
GNAS	2778	broad.mit.edu	37	20	57429123	57429123	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:57429123C>T	uc002xzw.2	+	1	1088	c.803C>T	c.(802-804)CCC>CTC	p.P268L	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CGCCTCACTCCCGCCGCGAAC	0.692			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			4	8					0	0	0.001168	0	0
ZNF831	128611	broad.mit.edu	37	20	57829713	57829713	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr20:57829713G>A	uc002yan.2	+	5	4949	c.4949G>A	c.(4948-4950)AGT>AAT	p.S1650N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1650						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AAGAAGAGGAGTCTGGAAGGA	0.443													18	40					0	0	0.007413	0	0
TPTE	7179	broad.mit.edu	37	21	10916473	10916473	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:10916473C>T	uc002yip.1	-	20	1541	c.1173G>A	c.(1171-1173)AAG>AAA	p.K391K	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Silent_p.K373K|TPTE_uc002yir.1_Silent_p.K353K|TPTE_uc010gkv.1_Silent_p.K253K	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	391	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAACATATCTCTTCTGAAAAG	0.338													20	38					0	0	0.010504	0	0
CHODL	140578	broad.mit.edu	37	21	19629025	19629025	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:19629025G>A	uc002ykv.2	+	2	670	c.279G>A	c.(277-279)GGG>GGA	p.G93G	CHODL_uc002ykr.2_Silent_p.G52G|CHODL_uc002yks.2_Silent_p.G52G|CHODL_uc002ykt.2_Silent_p.G52G|CHODL_uc002yku.2_Silent_p.G52G	NM_024944	NP_079220	Q9H9P2	CHODL_HUMAN	chondrolectin precursor	93	Extracellular (Potential).|C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			upper_aerodigestive_tract(1)	1		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CCGGGACAGGGATTTCTGATG	0.488													34	55					0	0	0.007835	0	0
RNF160	26046	broad.mit.edu	37	21	30316752	30316752	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:30316752G>A	uc002ymr.2	-	22	4086	c.4073C>T	c.(4072-4074)TCC>TTC	p.S1358F		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1312							ligase activity|zinc ion binding				0						GATGCCTTGGGAAAAAAATTC	0.383													28	46					0	0	0.009535	0	0
DONSON	29980	broad.mit.edu	37	21	34951847	34951847	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:34951847T>C	uc002ysk.2	-	9	1439	c.1372A>G	c.(1372-1374)ACA>GCA	p.T458A	DONSON_uc002ysi.1_Missense_Mutation_p.T218A|DONSON_uc002ysj.2_Missense_Mutation_p.T91A|DONSON_uc002ysl.2_Missense_Mutation_p.T91A|DONSON_uc010gme.2_Missense_Mutation_p.T431A|DONSON_uc002ysm.2_Missense_Mutation_p.T458A	NM_017613	NP_060083	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	458					multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2						AGAGCTTGTGTCTTCACATTC	0.378													15	23					0	0	0.004007	0	0
DSCAM	1826	broad.mit.edu	37	21	41668072	41668072	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:41668072C>T	uc002yyq.1	-	10	2544	c.2092G>A	c.(2092-2094)GAC>AAC	p.D698N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	698	Extracellular (Potential).|Ig-like C2-type 8.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CCGTCCTGGTCCCGTGGCTGA	0.433													21	24					0	0	0.010504	0	0
DSCAM	1826	broad.mit.edu	37	21	41725663	41725663	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:41725663C>T	uc002yyq.1	-	5	1115	c.663G>A	c.(661-663)GCG>GCA	p.A221A	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	221	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGGCTGAGTTCGCTGGGTCTG	0.498													6	7					0	0	0.001168	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45499524	45499524	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:45499524C>T	uc002zea.2	+	12	1718	c.1549C>T	c.(1549-1551)CCC>TCC	p.P517S	TRAPPC10_uc010gpo.2_Missense_Mutation_p.P228S	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	517					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CTGGGCACTCCCCATCACACA	0.428													8	16					0	0	0.004482	0	0
TRPM2	7226	broad.mit.edu	37	21	45786783	45786783	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr21:45786783C>T	uc002zet.1	+	5	783	c.570C>T	c.(568-570)TTC>TTT	p.F190F	TRPM2_uc002zeu.1_Silent_p.F190F|TRPM2_uc002zew.1_Silent_p.F190F|TRPM2_uc010gpt.1_Silent_p.F190F|TRPM2_uc002zex.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	190	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGAGCATTTTCCGCAGAGGCC	0.642													11	7					0	0	0.010729	0	0
KLHL22	84861	broad.mit.edu	37	22	20796379	20796379	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:20796379T>C	uc002zsl.1	-	7	1995	c.1886A>G	c.(1885-1887)GAC>GGC	p.D629G	KLHL22_uc011ahr.1_Missense_Mutation_p.D486G	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	629					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			ACTGGAGTTGTCAAACTCCTC	0.642													5	28					0	0	0.001168	0	0
MMP11	4320	broad.mit.edu	37	22	24122788	24122788	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:24122788C>T	uc002zxx.2	+	4	524	c.502C>T	c.(502-504)CTG>TTG	p.L168L	MMP11_uc002zxy.2_RNA|MMP11_uc002zxz.2_5'Flank	NM_005940	NP_005931	P24347	MMP11_HUMAN	matrix metalloproteinase 11 preproprotein	168					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|large_intestine(1)	3		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				TGGGGACGACCTGCCGTTTGA	0.632													28	5					0	0	0.009535	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659578	24659578	+	RNA	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:24659578A>G	uc002zzs.3	+	7		c.3310A>G			uc011ajp.1_5'Flank	NR_003714				Homo sapiens mRNA; cDNA DKFZp434P211 (from clone DKFZp434P211).												0						TGCGCAGGCCAACACTCACTG	0.617													5	11					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	22	25679005	25679005	+	RNA	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:25679005C>T	uc003abq.1	-	1		c.57G>A								Homo sapiens cDNA clone IMAGE:5267701.																		GCAAGAGGACCGTCCTGCCCG	0.721													5	3					0	0	0.001168	0	0
SEZ6L	23544	broad.mit.edu	37	22	26743711	26743711	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:26743711G>A	uc003acb.2	+	11	2395	c.2239G>A	c.(2239-2241)GAT>AAT	p.D747N	SEZ6L_uc003acc.2_Missense_Mutation_p.D747N|SEZ6L_uc011akc.1_Missense_Mutation_p.D747N|SEZ6L_uc003acd.2_Missense_Mutation_p.D747N|SEZ6L_uc011akd.1_Missense_Mutation_p.D747N|SEZ6L_uc003ace.2_Missense_Mutation_p.D747N|SEZ6L_uc003acf.1_Missense_Mutation_p.D520N|SEZ6L_uc010gvc.1_Missense_Mutation_p.D520N|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	747	Sushi 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTCCTGCTCGGATTTACCCGA	0.512													46	8					0	0	0.014410	0	0
DUSP18	150290	broad.mit.edu	37	22	31059833	31059833	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:31059833G>A	uc003aiu.2	-	2	659	c.158C>T	c.(157-159)TCA>TTA	p.S53L	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Missense_Mutation_p.S53L	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	53						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TACCTCCACTGAGACATTGAT	0.483													105	27					0	0	0.014410	0	0
FOXRED2	80020	broad.mit.edu	37	22	36892219	36892219	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:36892219G>A	uc003apn.3	-	6	1527	c.1419C>T	c.(1417-1419)CCC>CCT	p.P473P	FOXRED2_uc003apm.3_Silent_p.P25P|FOXRED2_uc003apo.3_Silent_p.P473P|FOXRED2_uc003app.3_Silent_p.P473P	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	473					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GCATCTGTATGGGGAACTCCT	0.597													51	12					0	0	0.014410	0	0
DNAJB7	150353	broad.mit.edu	37	22	41257784	41257784	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:41257784C>T	uc003azj.2	-	1	347	c.215G>A	c.(214-216)GGA>GAA	p.G72E	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_RNA|XPNPEP3_uc003azf.1_RNA|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	72					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						TCCGTTTAATCCTTCTGTGCC	0.358													154	38					0	0	0.014410	0	0
TCF20	6942	broad.mit.edu	37	22	42608428	42608428	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:42608428G>A	uc003bcj.1	-	1	3018	c.2884C>T	c.(2884-2886)CGC>TGC	p.R962C	TCF20_uc003bck.1_Missense_Mutation_p.R962C|TCF20_uc003bnt.2_Missense_Mutation_p.R962C	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	962					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						GCATTGCCGCGGTAAGACTCA	0.522													98	26					0	0	0.014410	0	0
EFCAB6	64800	broad.mit.edu	37	22	43996104	43996104	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr22:43996104T>C	uc003bdy.1	-	23	2936	c.2721A>G	c.(2719-2721)GAA>GAG	p.E907E	EFCAB6_uc003bdz.1_Silent_p.E755E|EFCAB6_uc010gzi.1_Silent_p.E755E|EFCAB6_uc010gzj.1_Silent_p.E133E	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	907	EF-hand 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TCTGTAAAAATTCCTGGTAAG	0.428													68	158					0	0	0.014410	0	0
ATP2B2	491	broad.mit.edu	37	3	10391802	10391802	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:10391802C>T	uc003bvt.2	-	16	2837	c.2398G>A	c.(2398-2400)GTT>ATT	p.V800I	ATP2B2_uc003bvv.2_Missense_Mutation_p.V755I|ATP2B2_uc003bvw.2_Missense_Mutation_p.V755I|ATP2B2_uc010hdo.2_Missense_Mutation_p.V505I	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	800	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTACCTTTAACCAGGGTATGC	0.597													6	21					0	0	0.003080	0	0
NUP210	23225	broad.mit.edu	37	3	13438860	13438860	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:13438860C>T	uc003bxv.1	-	3	516	c.433G>A	c.(433-435)GAA>AAA	p.E145K		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	145	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					TTCTCACCTTCGGAGTCCAGG	0.592													12	15					0	0	0.003163	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115510	15115510	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:15115510C>T	uc003bzm.1	-	14	2748	c.2134G>A	c.(2134-2136)GAG>AAG	p.E712K	ZFYVE20_uc010hek.1_Missense_Mutation_p.E712K	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	712	Necessary for the interaction with RAB5A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GTGGGTTCCTCAAAGGGGTTA	0.552													21	40					0	0	0.010504	0	0
EFHB	151651	broad.mit.edu	37	3	19975432	19975432	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:19975432G>A	uc003cbl.3	-	1	275	c.79C>T	c.(79-81)CCC>TCC	p.P27S	EFHB_uc003cbm.2_Intron	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	27					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						AACTCCATGGGAAATTTTGTT	0.483													14	20					0	0	0.001855	0	0
KAT2B	8850	broad.mit.edu	37	3	20153274	20153274	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:20153274C>T	uc003cbq.2	+	6	1484	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	346					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCACTCATTTCCCAAAGTAAG	0.423													6	21					0	0	0.003080	0	0
CCR4	1233	broad.mit.edu	37	3	32995941	32995941	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:32995941C>A	uc003cfg.1	+	2	1195	c.1027C>A	c.(1027-1029)CCC>ACC	p.P343T		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	343	Cytoplasmic (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						TGCTGACACCCCCAGCTCATC	0.453													5	33					0.00116845	0.00367226	0.001168	1	0
ZNF619	285267	broad.mit.edu	37	3	40523445	40523445	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:40523445C>T	uc011azb.1	+	3	394	c.116C>T	c.(115-117)CCT>CTT	p.P39L	ZNF619_uc010hhz.2_Silent_p.P6P|ZNF619_uc003ckj.2_Silent_p.P6P|ZNF619_uc011azc.1_Missense_Mutation_p.P39L|ZNF619_uc011azd.1_Intron|ZNF619_uc011aza.1_5'UTR	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	39					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGCCTGCACCCTACGCAGAGG	0.527													38	60					0	0	0.010771	0	0
HHATL	57467	broad.mit.edu	37	3	42739839	42739839	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:42739839C>T	uc003clw.2	-	7	635	c.488G>A	c.(487-489)GGG>GAG	p.G163E	HHATL_uc003clx.2_Missense_Mutation_p.G163E	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	163					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TGTTACAAACCCGCTCTGGAG	0.577													14	24					0	0	0.002450	0	0
LTF	4057	broad.mit.edu	37	3	46497363	46497363	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:46497363G>A	uc003cpq.2	-	4	460	c.422C>T	c.(421-423)ACC>ATC	p.T141I	LTF_uc003fzr.2_Missense_Mutation_p.T97I|LTF_uc010hjh.2_Missense_Mutation_p.T141I|LTF_uc003cpr.2_Missense_Mutation_p.T128I	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor	141	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CCATCCAGCGGTCCTGCGAAG	0.552													13	22					0	0	0.002450	0	0
LAMB2	3913	broad.mit.edu	37	3	49159020	49159020	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:49159020T>C	uc003cwe.2	-	31	5405	c.5106A>G	c.(5104-5106)CTA>CTG	p.L1702L	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1702	Potential.|Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GAGGACCGCGTAGCAGCTGCA	0.612													4	27					0	0	0.009096	0	0
DNAH1	25981	broad.mit.edu	37	3	52356589	52356589	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:52356589G>A	uc011bef.1	+	2	392	c.131G>A	c.(130-132)GGA>GAA	p.G44E	DNAH1_uc003ddt.1_Missense_Mutation_p.G44E	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	44	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATTCTTCCAGGATCAGACTAT	0.617													11	16					0	0	0.013537	0	0
DNAH1	25981	broad.mit.edu	37	3	52431002	52431002	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:52431002A>C	uc011bef.1	+	73	11990	c.11729A>C	c.(11728-11730)GAG>GCG	p.E3910A	DNAH1_uc003ddv.2_Missense_Mutation_p.E768A	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3975					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTCTCCCCTGAGCACAGCTAC	0.617													3	3					0	0	0.004672	0	0
CACNA1D	776	broad.mit.edu	37	3	53845310	53845310	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:53845310C>T	uc003dgv.3	+	48	6526	c.6363C>T	c.(6361-6363)CCC>CCT	p.P2121P	CACNA1D_uc003dgu.3_Silent_p.P2141P|CACNA1D_uc003dgy.3_Silent_p.P2097P|CACNA1D_uc003dgw.3_Silent_p.P1788P|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	2121	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATGTGGGCCCCCTCTCACACC	0.612													13	31					0	0	0.001855	0	0
EPHA6	285220	broad.mit.edu	37	3	97194224	97194224	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:97194224G>A	uc010how.1	+	8	1966	c.1923G>A	c.(1921-1923)CAG>CAA	p.Q641Q	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Silent_p.Q7Q|EPHA6_uc003drs.3_Silent_p.Q33Q|EPHA6_uc003drr.3_Silent_p.Q33Q|EPHA6_uc003drt.2_Silent_p.Q33Q|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	546	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						AACAAGGACAGATTCTCGTGA	0.413													19	12					0	0	0.010504	0	0
IMPG2	50939	broad.mit.edu	37	3	100961721	100961721	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:100961721C>T	uc003duq.1	-	14	3036	c.2833G>A	c.(2833-2835)GGG>AGG	p.G945R	IMPG2_uc011bhe.1_Missense_Mutation_p.G808R	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	945	Extracellular (Potential).|SEA 2.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TTCTGGAACCCCGTGAGATTT	0.408													19	37					0	0	0.012319	0	0
ZPLD1	131368	broad.mit.edu	37	3	102187967	102187967	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:102187967C>T	uc003dvs.1	+	15	1803	c.921C>T	c.(919-921)CCC>CCT	p.P307P	ZPLD1_uc003dvt.1_Silent_p.P323P|ZPLD1_uc011bhg.1_Silent_p.P307P	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	307	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ATGACTGCCCCTTCCTTATGC	0.383													15	43					0	0	0.006122	0	0
MYH15	22989	broad.mit.edu	37	3	108135721	108135721	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:108135721C>T	uc003dxa.1	-	30	4003	c.3946G>A	c.(3946-3948)GAA>AAA	p.E1316K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1316	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTGCTCTTTTCCCTGGAAAGT	0.418													21	37					0	0	0.010504	0	0
TRAT1	50852	broad.mit.edu	37	3	108572538	108572538	+	Silent	SNP	G	A	A	rs143422005		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:108572538G>A	uc003dxi.1	+	6	519	c.375G>A	c.(373-375)AGG>AGA	p.R125R	TRAT1_uc010hpx.1_Silent_p.R88R	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	125	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity	p.R125R(1)		skin(1)	1						GAAAGCCCAGGAAACAGAATA	0.433													23	29					0	0	0.014323	0	0
MORC1	27136	broad.mit.edu	37	3	108723921	108723921	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:108723921G>A	uc003dxl.2	-	19	2096	c.2009C>T	c.(2008-2010)TCC>TTC	p.S670F	MORC1_uc011bhn.1_Missense_Mutation_p.S649F	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	670					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TAATACCTGGGATCTCTCAGC	0.338													28	68					0	0	0.008361	0	0
DPPA4	55211	broad.mit.edu	37	3	109049504	109049504	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:109049504G>A	uc003dxq.3	-	5	601	c.546C>T	c.(544-546)TCC>TCT	p.S182S	DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Silent_p.S182S	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	182						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GGAGAGCAGTGGAATTTTCCA	0.557													26	52					0	0	0.005443	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976086	120976086	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:120976086C>T	uc003eec.3	+	17	1878	c.1738C>T	c.(1738-1740)CTC>TTC	p.L580F	STXBP5L_uc011bji.1_Missense_Mutation_p.L580F	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	580	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GTTTCCAGATCTCTCAGCCCA	0.403													40	58					0	0	0.009718	0	0
FBXO40	51725	broad.mit.edu	37	3	121340659	121340659	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:121340659C>T	uc003eeg.2	+	3	593	c.383C>T	c.(382-384)GCC>GTC	p.A128V		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	128					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		TTGGACACAGCCCTGGCCCTG	0.498													17	21					0	0	0.004007	0	0
HEG1	57493	broad.mit.edu	37	3	124739640	124739640	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:124739640G>A	uc003ehs.3	-	4	1316	c.1248C>T	c.(1246-1248)TCC>TCT	p.S416S	HEG1_uc011bke.1_Silent_p.S416S	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	416	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						ACTTACTTGGGGAATCATTTT	0.383													21	36					0	0	0.010504	0	0
UROC1	131669	broad.mit.edu	37	3	126226832	126226832	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:126226832C>T	uc003eiz.1	-	5	550	c.518G>A	c.(517-519)CGG>CAG	p.R173Q	UROC1_uc010hsi.1_Missense_Mutation_p.R173Q	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	173					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		GATGACGAGCCGTGGGGCACT	0.592													21	29					0	0	0.012319	0	0
IL20RB	53833	broad.mit.edu	37	3	136701038	136701038	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:136701038C>T	uc003eri.1	+	3	501	c.252C>T	c.(250-252)ATC>ATT	p.I84I	IL20RB_uc003erj.1_RNA|IL20RB_uc010hud.1_5'UTR	NM_144717	NP_653318	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta precursor	84	Fibronectin type-III 1.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1						ACATCTGGATCCCCAGCAGCT	0.557													9	20					0	0	0.001855	0	0
ATR	545	broad.mit.edu	37	3	142215245	142215245	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:142215245G>A	uc003eux.3	-	34	5978	c.5856C>T	c.(5854-5856)CTC>CTT	p.L1952L		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1952	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						ACAGTTCAGCGAGTCGTGATT	0.443								Other_conserved_DNA_damage_response_genes					24	17					0	0	0.012213	0	0
PLS1	5357	broad.mit.edu	37	3	142405183	142405183	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:142405183G>A	uc010huv.2	+	9	1105	c.946G>A	c.(946-948)GGA>AGA	p.G316R	PLS1_uc003euz.2_Missense_Mutation_p.G316R|PLS1_uc003eva.2_Missense_Mutation_p.G316R	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	316	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						TGGGGAAGATGGACCTGCCAT	0.289													29	30					0	0	0.004878	0	0
OTOL1	131149	broad.mit.edu	37	3	161214851	161214851	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:161214851C>T	uc011bpb.1	+	1	256	c.256C>T	c.(256-258)CCC>TCC	p.P86S		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	86						collagen					0						CACTCTCTCTCCCTTTGAAAA	0.463													42	40					0	0	0.014410	0	0
PLD1	5337	broad.mit.edu	37	3	171427469	171427470	+	Missense_Mutation	DNP	TC	GT	GT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:171427469_171427470TC>GT	uc003fhs.2	-	10	1057_1058	c.941_942GA>AC	c.(940-942)AGA>AAC	p.R314N	PLD1_uc003fht.2_Missense_Mutation_p.R314N	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	314	PH.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACCGAGCATGTCTATAGCTGTT	0.386													24	53					0	0	0.004672	0	0
CPN2	1370	broad.mit.edu	37	3	194062986	194062986	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:194062986G>A	uc003fts.2	-	2	536	c.446C>T	c.(445-447)TCC>TTC	p.S149F		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	149	LRR 3.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CAGGTGGAGGGACTCCAGGGC	0.622													18	27					0	0	0.007413	0	0
CRMP1	1400	broad.mit.edu	37	4	5841406	5841406	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:5841406C>T	uc003gip.2	-	10	913	c.812_splice	c.e10-1	p.G271_splice	CRMP1_uc003gin.1_Splice_Site_p.G183_splice|CRMP1_uc003giq.2_Splice_Site_p.G271_splice|CRMP1_uc003gir.2_Splice_Site_p.G266_splice|CRMP1_uc003gis.2_Splice_Site_p.G385_splice	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2						axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		ACTAGGGGCCCTTAGGAGGGG	0.547													6	1					0	0	0.001168	0	0
RPL9	6133	broad.mit.edu	37	4	39456226	39456226	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:39456226G>A	uc003gub.2	-	6	664	c.516C>T	c.(514-516)ATC>ATT	p.I172I	RPL9_uc003guc.2_Silent_p.I172I|RPL9_uc011byk.1_RNA	NM_001024921	NP_001020092	P32969	RL9_HUMAN	ribosomal protein L9	172					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|nucleolus|ribosome	rRNA binding|structural constituent of ribosome			skin(1)	1						AAAATTTCCTGATATCCTTGT	0.353													17	7					0	0	0.006122	0	0
FRYL	285527	broad.mit.edu	37	4	48545867	48545867	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:48545867G>A	uc003gyh.1	-	44	6154	c.5549C>T	c.(5548-5550)TCC>TTC	p.S1850F	FRYL_uc003gyg.1_Missense_Mutation_p.S546F|FRYL_uc003gyi.1_Missense_Mutation_p.S738F|FRYL_uc003gyj.1_Missense_Mutation_p.S145F	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1850					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TACAAGTCTGGAGAGAACATC	0.438													28	12					0	0	0.005524	0	0
LRRC66	339977	broad.mit.edu	37	4	52861333	52861333	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:52861333C>T	uc003gzi.2	-	4	1868	c.1855G>A	c.(1855-1857)GAA>AAA	p.E619K		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	619						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TTAGAAAATTCCATCTGCGAG	0.502													33	12					0	0	0.003271	0	0
LRRC66	339977	broad.mit.edu	37	4	52883468	52883468	+	Silent	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:52883468A>G	uc003gzi.2	-	1	325	c.312T>C	c.(310-312)CCT>CCC	p.P104P		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	104	LRR 1.					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						AATATGCAAAAGGGCTTAAGG	0.388													3	83					0	0	0.004672	0	0
PDGFRA	5156	broad.mit.edu	37	4	54256018	54256018	+	Silent	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:54256018G>T	uc003haa.2	+	6	561	c.375G>T	c.(373-375)GGG>GGT	p.G125G	FIP1L1_uc003gzx.3_Silent_p.G110G|FIP1L1_uc011bzt.1_Silent_p.G125G|FIP1L1_uc003gzy.2_Silent_p.G125G|FIP1L1_uc011bzu.1_Silent_p.G110G|FIP1L1_uc003gzz.2_Silent_p.G110G|FIP1L1_uc003hab.2_Silent_p.G113G|FIP1L1_uc003hac.2_Intron	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	Error:Variant_position_missing_in_P16234_after_alignment					cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TCAAGACAGGGGGAAGAGTTT	0.303			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			6	77					0.00307968	0.00962559	0.003080	1	0
SULT1E1	6783	broad.mit.edu	37	4	70710024	70710024	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:70710024G>A	uc003heo.2	-	7	740	c.627C>T	c.(625-627)TTC>TTT	p.F209F		NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	209	PAPS.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						TCCTTTCCAGGAAATGTATCA	0.353													40	24					0	0	0.011902	0	0
ALB	213	broad.mit.edu	37	4	74277741	74277741	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:74277741C>T	uc003hgs.3	+	7	815	c.742C>T	c.(742-744)CCC>TCC	p.P248S	ALB_uc003hgw.3_Missense_Mutation_p.P56S|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Missense_Mutation_p.P248S|ALB_uc010iii.2_Missense_Mutation_p.P133S|ALB_uc003hgu.3_Missense_Mutation_p.P98S|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Missense_Mutation_p.P138S|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	248	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CCAGAGATTTCCCAAAGCTGA	0.413													44	25					0	0	0.014410	0	0
PRKG2	5593	broad.mit.edu	37	4	82125817	82125817	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:82125817G>A	uc003hmh.2	-	1	399	c.385C>T	c.(385-387)CCA>TCA	p.P129S	PRKG2_uc011cch.1_Missense_Mutation_p.P129S	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	129					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						CGGGTTGTTGGCTCAGCAGAC	0.507													104	58					0	0	0.014410	0	0
ANK2	287	broad.mit.edu	37	4	114294517	114294517	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:114294517C>T	uc003ibe.3	+	45	11871	c.11771C>T	c.(11770-11772)CCA>CTA	p.P3924L	ANK2_uc003ibd.3_Missense_Mutation_p.P1830L|ANK2_uc003ibf.3_Missense_Mutation_p.P1839L|ANK2_uc011cgc.1_Missense_Mutation_p.P1015L|ANK2_uc003ibg.3_Missense_Mutation_p.P854L|ANK2_uc003ibh.3_Missense_Mutation_p.P544L|ANK2_uc011cgd.1_Missense_Mutation_p.P1226L|ANK2_uc010imr.2_Missense_Mutation_p.P6L|ANK2_uc010ims.2_Missense_Mutation_p.P6L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3891					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGGGAATGCCACAGGAACCT	0.433													45	23					0	0	0.013114	0	0
CEP170L	645455	broad.mit.edu	37	4	119472291	119472291	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:119472291C>T	uc003icb.2	+	6	588	c.504C>T	c.(502-504)GCC>GCT	p.A168A		NR_003135				RecName: Full=Cep170-like protein;												0						AATTAAGAGCCGAAAGTGAAG	0.274													16	9					0	0	0.008871	0	0
DCLK2	166614	broad.mit.edu	37	4	151114386	151114386	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:151114386C>T	uc003ilm.3	+	3	953	c.853C>T	c.(853-855)CAT>TAT	p.H285Y	DCLK2_uc003iln.3_Missense_Mutation_p.H285Y|DCLK2_uc003ilo.3_Missense_Mutation_p.H285Y|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	285					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					TGTCCTGGATCATAGTGGTAA	0.393													51	24					0	0	0.014410	0	0
TRIM61	391712	broad.mit.edu	37	4	165890999	165890999	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:165890999G>A	uc003iqw.2	-	3	767	c.156C>T	c.(154-156)CCC>CCT	p.P52P		NM_001012414	NP_001012414	Q5EBN2	TRI61_HUMAN	tripartite motif-containing 61	52	RING-type.					intracellular	zinc ion binding	p.P52L(1)		skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		AAAAGGGGCAGGGGAAACTAT	0.453													22	10					0	0	0.014323	0	0
SLC12A7	10723	broad.mit.edu	37	5	1053505	1053505	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:1053505T>C	uc003jbu.2	-	23	3185	c.3119A>G	c.(3118-3120)AAC>AGC	p.N1040S		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	1040	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ACCTGGCATGTTGAGCAGGAC	0.612													6	30					0	0	0.001984	0	0
SLC6A3	6531	broad.mit.edu	37	5	1422009	1422009	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:1422009G>A	uc003jck.2	-	5	895	c.774C>T	c.(772-774)GGC>GGT	p.G258G		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	258					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	AGGTCTTCACGCCCTTCCAGA	0.637													41	67					0	0	0.011902	0	0
DNAH5	1767	broad.mit.edu	37	5	13737376	13737376	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:13737376C>T	uc003jfd.2	-	66	11482	c.11440G>A	c.(11440-11442)GAG>AAG	p.E3814K	DNAH5_uc003jfc.2_Intron	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3814	Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTGTATTCCTCCCGGGCTGAG	0.428									Kartagener_syndrome				87	28					0	0	0.014410	0	0
DNAH5	1767	broad.mit.edu	37	5	13763005	13763005	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:13763005G>A	uc003jfd.2	-	60	10149	c.10107C>T	c.(10105-10107)TTC>TTT	p.F3369F	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3369	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.F3369L(1)		ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGTCTTTTGGGAATTGCTATG	0.368									Kartagener_syndrome				51	8					0	0	0.014410	0	0
DNAH5	1767	broad.mit.edu	37	5	13891126	13891126	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:13891126C>T	uc003jfd.2	-	17	2578	c.2536G>A	c.(2536-2538)GAG>AAG	p.E846K		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	846	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGTGGCTCCTCCTGGGGAAGC	0.413									Kartagener_syndrome				94	98					0	0	0.014410	0	0
SPEF2	79925	broad.mit.edu	37	5	35806838	35806838	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:35806838G>A	uc003jjo.2	+	35	5151	c.5040G>A	c.(5038-5040)GAG>GAA	p.E1680E	SPEF2_uc003jjp.1_Silent_p.E1166E|SPEF2_uc003jjr.2_Silent_p.E735E	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1680					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTCCAGCTGAGGAATTTCCTG	0.393													6	49					0	0	0.001984	0	0
IL7R	3575	broad.mit.edu	37	5	35871189	35871189	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:35871189C>T	uc003jjs.2	+	4	500	c.411C>T	c.(409-411)GTC>GTT	p.V137V	IL7R_uc011coo.1_Silent_p.V137V|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	137	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			ACCTGAGTGTCGTCTATCGGG	0.368													15	93					0	0	0.004990	0	0
C9	735	broad.mit.edu	37	5	39308393	39308393	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:39308393T>C	uc003jlv.3	-	8	1268	c.1179A>G	c.(1177-1179)GAA>GAG	p.E393E		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	393	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CAACAGAGATTTCAGAGAAAG	0.358													13	86					0	0	0.013537	0	0
RGS7BP	401190	broad.mit.edu	37	5	63894231	63894231	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:63894231G>A	uc003jtj.2	+	5	651	c.651G>A	c.(649-651)AGG>AGA	p.R217R	RGS7BP_uc011cqu.1_Silent_p.R84R	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding	217					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane					0		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		GCAAACTCAGGGAAACTATGC	0.333													67	96					0	0	0.014410	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64558776	64558776	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:64558776C>T	uc003jtp.2	-	13	2448	c.1634G>A	c.(1633-1635)GGA>GAA	p.G545E	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Missense_Mutation_p.G166E	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	545	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AACACAATCTCCCTGATAACA	0.512													11	13					0	0	0.013537	0	0
ENC1	8507	broad.mit.edu	37	5	73931417	73931417	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:73931417G>A	uc003kdc.3	-	2	2025	c.894C>T	c.(892-894)TTC>TTT	p.F298F	ENC1_uc011css.1_Silent_p.F225F	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	298	Kelch 1.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CTCCCAGAAGGAAGAGGGCAT	0.507													9	20					0	0	0.004482	0	0
AQPEP	206338	broad.mit.edu	37	5	115327844	115327844	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:115327844A>G	uc003kro.2	+	5	1294	c.1130A>G	c.(1129-1131)GAC>GGC	p.D377G	AQPEP_uc003krp.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	377	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CCTAGTTTTGACAACCATGCA	0.318													3	75					0	0	0.004672	0	0
DMXL1	1657	broad.mit.edu	37	5	118576136	118576136	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:118576136C>T	uc003ksd.2	+	41	8792	c.8611C>T	c.(8611-8613)CTT>TTT	p.L2871F	DMXL1_uc010jcl.1_Missense_Mutation_p.L2892F|DMXL1_uc010jcm.1_RNA|DMXL1_uc003kse.1_Missense_Mutation_p.L45F	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2871	WD 12.									ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GTGGGATACTCTTGTAGCACC	0.289													42	43					0	0	0.014410	0	0
LRRTM2	26045	broad.mit.edu	37	5	138209934	138209934	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:138209934G>A	uc011cyz.1	-	2	773	c.316C>T	c.(316-318)CAA>TAA	p.Q106*	CTNNA1_uc003ldh.2_Intron|CTNNA1_uc011cyx.1_Intron|CTNNA1_uc011cyy.1_Intron|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Intron|LRRTM2_uc010jez.2_Intron|LRRTM2_uc011cza.1_Intron|CTNNA1_uc003ldl.2_5'Flank	NM_015564	NP_056379	O43300	LRRT2_HUMAN	leucine rich repeat transmembrane neuronal 2	106	LRR 2.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TATAGTCCTTGAAAAGCATCT	0.338													12	52					0	0	0.010729	0	0
HARS	3035	broad.mit.edu	37	5	140062741	140062741	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140062741G>A	uc003lgv.2	-	3	326	c.244C>T	c.(244-246)CGT>TGT	p.R82C	HARS_uc003lgu.2_Missense_Mutation_p.R13C|HARS_uc011czm.1_Intron|HARS_uc003lgw.2_Missense_Mutation_p.R82C|HARS_uc011czn.1_Intron|HARS_uc010jfu.2_Missense_Mutation_p.R82C|HARS_uc011czo.1_Missense_Mutation_p.R82C|HARS_uc011czp.1_Intron|HARS_uc011czq.1_Missense_Mutation_p.R82C	NM_002109	NP_002100	P12081	SYHC_HUMAN	histidyl-tRNA synthetase	82					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	TTGAAGCAACGGATGATTACG	0.483													17	48					0	0	0.006122	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167118	140167118	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140167118C>T	uc003lhb.2	+	1	1243	c.1243C>T	c.(1243-1245)CGC>TGC	p.R415C	PCDHA1_uc003lha.2_Missense_Mutation_p.R415C|PCDHA1_uc003lgz.2_Missense_Mutation_p.R415C	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCTGGATCGCGAGAGCCT	0.637													28	68					0	0	0.010818	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174764	140174764	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140174764G>A	uc003lhd.2	+	1	321	c.215G>A	c.(214-216)GGG>GAG	p.G72E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.G72E|PCDHA2_uc011czy.1_Missense_Mutation_p.G72E	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	72	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAAGACACGGGGACCTTCTG	0.622													34	48					0	0	0.005524	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182643	140182644	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140182643_140182644CC>TT	uc003lhf.2	+	1	1861_1862	c.1861_1862CC>TT	c.(1861-1863)CCG>TTG	p.P621L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.P621L	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	621	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGCATCCCGTTTCGCGTG	0.668													8	25					0	0	0.004672	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229697	140229697	+	Missense_Mutation	SNP	C	G	G	rs141845549		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140229697C>G	uc003lhu.2	+	1	2341	c.1617C>G	c.(1615-1617)GAC>GAG	p.D539E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.D539E	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	539	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGCGACGCGGGCGTGC	0.672													44	48					0	0	0.014410	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256014	140256014	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140256014G>A	uc003lic.2	+	1	1084	c.957G>A	c.(955-957)CAG>CAA	p.Q319Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.Q319Q	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	319	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAAATTCAGGTTAACGCCA	0.398													39	37					0	0	0.006230	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503257	140503257	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140503257C>T	uc003lip.1	+	1	1677	c.1677C>T	c.(1675-1677)TTC>TTT	p.F559F		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	559	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCCCTTCGTGCTGTACC	0.701													11	16					0	0	0.007413	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554534	140554534	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140554534C>T	uc003lit.2	+	1	2292	c.2118C>T	c.(2116-2118)TTC>TTT	p.F706F	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	706	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGTTCGTGGCGGTGC	0.692													48	105					0	0	0.014410	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563504	140563504	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140563504C>T	uc003liv.2	+	1	2525	c.1370C>T	c.(1369-1371)ACC>ATC	p.T457I	PCDHB16_uc010jfw.1_Missense_Mutation_p.T129I	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	457	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTCCTACACCCTGTTCGTC	0.562													32	40					0	0	0.003755	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626131	140626131	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140626131G>A	uc003lje.2	+	1	985	c.985G>A	c.(985-987)GGA>AGA	p.G329R		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	329	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGACTTTCTGGAAAATGCTC	0.413													19	60					0	0	0.008871	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140779095	140779095	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140779095C>T	uc003lkf.1	+	1	1401	c.1401C>T	c.(1399-1401)ATC>ATT	p.I467I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Silent_p.I467I	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	467	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCCTCCATCGCGCAAGTCT	0.567													18	8					0	0	0.012319	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865237	140865237	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:140865237C>T	uc003lky.1	+	1	497	c.497C>T	c.(496-498)TCG>TTG	p.S166L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.S166L	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	166	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAGCAATTCGATTAGCAGC	0.567													20	20					0	0	0.012319	0	0
FGF1	2246	broad.mit.edu	37	5	141993542	141993542	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:141993542C>T	uc003lmm.2	-	2	231	c.151G>A	c.(151-153)GAC>AAC	p.D51N	FGF1_uc011dbi.1_Missense_Mutation_p.D51N|FGF1_uc003lmn.3_Missense_Mutation_p.D51N|FGF1_uc003lmp.3_Missense_Mutation_p.D51N|FGF1_uc003lmq.2_Missense_Mutation_p.D51N|FGF1_uc010jgj.2_Missense_Mutation_p.D51N|FGF1_uc003lmr.2_Missense_Mutation_p.D51N|FGF1_uc003lms.3_Missense_Mutation_p.D51N	NM_001144892	NP_001138364	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic) isoform 1	51					angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding				0		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	TCGCTCCTGTCCCTTGTCCCA	0.542													10	14					0	0	0.010729	0	0
PLAC8L1	153770	broad.mit.edu	37	5	145483828	145483828	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:145483828G>A	uc003lnv.2	-	1	119	c.47C>T	c.(46-48)TCC>TTC	p.S16F	PLAC8L1_uc011dbp.1_RNA	NM_001029869	NP_001025040	A1L4L8	PL8L1_HUMAN	PLAC8-like 1	16											0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTGAGTAAGGAAAGATCCTC	0.398													8	21					0	0	0.004482	0	0
LARS	51520	broad.mit.edu	37	5	145557158	145557158	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:145557158G>C	uc003lnx.1	-	2	315	c.77C>G	c.(76-78)ACT>AGT	p.T26S	LARS_uc011dbq.1_Missense_Mutation_p.T26S|LARS_uc011dbr.1_Intron|LARS_uc011dbs.1_Missense_Mutation_p.T26S	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	26					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CACTCTCTCAGTATCCCATTT	0.343													3	66					0	0	0.009096	0	0
GPR151	134391	broad.mit.edu	37	5	145894714	145894714	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:145894714C>T	uc003lod.1	-	1	963	c.963G>A	c.(961-963)TGG>TGA	p.W321*		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	321	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCATCCATTTCCATACACCTT	0.448													14	29					0	0	0.001855	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145972568	145972568	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:145972568C>T	uc003loe.2	-	8	1543	c.1018G>A	c.(1018-1020)GAT>AAT	p.D340N	PPP2R2B_uc010jgm.2_Missense_Mutation_p.D329N|PPP2R2B_uc003log.3_Missense_Mutation_p.D340N|PPP2R2B_uc003lof.3_Missense_Mutation_p.D340N|PPP2R2B_uc003loi.3_Missense_Mutation_p.D343N|PPP2R2B_uc003loh.3_Missense_Mutation_p.D340N|PPP2R2B_uc003loj.3_Missense_Mutation_p.D320N|PPP2R2B_uc003lok.3_Missense_Mutation_p.D329N|PPP2R2B_uc011dbu.1_Missense_Mutation_p.D346N|PPP2R2B_uc011dbv.1_Missense_Mutation_p.D398N	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	340	WD 6.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAAATTTATCAAAAATGCAG	0.418													64	90					0	0	0.014410	0	0
GALNT10	55568	broad.mit.edu	37	5	153755896	153755896	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:153755896C>T	uc003lvh.2	+	5	760	c.628C>T	c.(628-630)CGA>TGA	p.R210*	GALNT10_uc003lvg.1_Nonsense_Mutation_p.R210*|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Intron	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	210	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GAGGATTCTTCGAACCAAGAA	0.502													23	48					0	0	0.014323	0	0
LARP1	23367	broad.mit.edu	37	5	154193632	154193632	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:154193632G>A	uc003lvp.2	+	19	3696	c.3267G>A	c.(3265-3267)TCG>TCA	p.S1089S	LARP1_uc003lvo.2_Silent_p.S1012S	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	1089							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCCAGCACTCGAACACACAGA	0.607													11	16					0	0	0.008291	0	0
SOX30	11063	broad.mit.edu	37	5	157078245	157078245	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:157078245G>A	uc003lxb.1	-	1	1184	c.842C>T	c.(841-843)TCA>TTA	p.S281L	SOX30_uc003lxc.1_Missense_Mutation_p.S281L|SOX30_uc011dds.1_Intron	NM_178424	NP_848511	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30 isoform a	281					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus|nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)|central_nervous_system(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TATCAGCTCTGAAGGCGGAGC	0.562													19	40					0	0	0.014323	0	0
CCNJL	79616	broad.mit.edu	37	5	159680613	159680613	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:159680613G>A	uc003lyb.1	-	7	1332	c.1080C>T	c.(1078-1080)TCC>TCT	p.S360S	CCNJL_uc011dee.1_Silent_p.S312S|CCNJL_uc003lyc.1_RNA	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	360						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGCCTGCAAGGAGTCCCGAT	0.657													16	16					0	0	0.004007	0	0
STK10	6793	broad.mit.edu	37	5	171481681	171481681	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:171481681C>T	uc003mbo.1	-	17	2844	c.2544G>A	c.(2542-2544)GAG>GAA	p.E848E		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	848	Gln-rich.|Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTGCCTCTTCTCCTCCTGCT	0.642													15	62					0	0	0.006122	0	0
FGFR4	2264	broad.mit.edu	37	5	176517572	176517572	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:176517572C>T	uc003mfl.2	+	3	440	c.273C>T	c.(271-273)TTC>TTT	p.F91F	FGFR4_uc003mfm.2_Silent_p.F91F|FGFR4_uc011dfu.1_Silent_p.F91F|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_Silent_p.F91F|FGFR4_uc011dfw.1_Silent_p.F91F|FGFR4_uc003mfo.2_Silent_p.F91F	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	91	Ig-like C2-type 1.|Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	TTGCCAGCTTCCTACCTGAGG	0.627										TSP Lung(9;0.080)			13	15					0	0	0.013537	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166145	180166145	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr5:180166145C>T	uc003mmf.1	-	1	914	c.914G>A	c.(913-915)TGG>TAG	p.W305*		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGCCCCTCCATAGTACTTT	0.423													49	58					0	0	0.014410	0	0
OR2B3	442184	broad.mit.edu	37	6	29055016	29055016	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:29055016C>T	uc003nlx.2	-	1	75	c.10G>A	c.(10-12)GAA>AAA	p.E4K		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						CTCTCATTTTCCCAATTCATG	0.363													4	24					0	0	0.009096	0	0
OR2H1	26716	broad.mit.edu	37	6	29430399	29430399	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:29430399C>T	uc003nmi.2	+	3	1296	c.853C>T	c.(853-855)CCT>TCT	p.P285S	OR2H1_uc003nmj.1_Missense_Mutation_p.P285S|OR2H1_uc010jri.1_Missense_Mutation_p.P207S	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCACTTAACCCTCTCGTATA	0.502													31	22					0	0	0.008361	0	0
TNXB	7148	broad.mit.edu	37	6	32036897	32036897	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:32036897C>T	uc003nzl.2	-	16	5806	c.5604G>A	c.(5602-5604)ACG>ACA	p.T1868T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1950					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTCAGTTTCCGTTTCTTCCC	0.627													31	151					0	0	0.011902	0	0
TNXB	7148	broad.mit.edu	37	6	32036905	32036906	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:32036905_32036906CC>TT	uc003nzl.2	-	16	5797_5798	c.5595_5596GG>AA	c.(5593-5598)AGGGAA>AGAAAA	p.E1866K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1948					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCCGTTTCTTCCCTGCCGGCTG	0.629													21	134					0	0	0.004672	0	0
RPS18	6222	broad.mit.edu	37	6	33243639	33243639	+	Silent	SNP	G	A	A	rs142232404	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:33243639G>A	uc003odp.1	+	3	213	c.168G>A	c.(166-168)GCG>GCA	p.A56A	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	56					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						CCAAGAGGGCGGGAGAACTCA	0.552													12	66					0	0	0.010729	0	0
PXT1	222659	broad.mit.edu	37	6	36368262	36368263	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:36368262_36368263CC>TT	uc003omd.1	-	1	49_50	c.19_20GG>AA	c.(19-21)GGG>AAG	p.G7K		NM_152990	NP_694535	Q8NFP0	PXT1_HUMAN	peroxisomal, testis specific 1	7						peroxisome					0						AATGTTGTCCCCAATGTGTCTC	0.485													19	82					0	0	0.004672	0	0
DNAH8	1769	broad.mit.edu	37	6	38754570	38754570	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:38754570C>T	uc003ooe.1	+	16	2374	c.1774C>T	c.(1774-1776)CCA>TCA	p.P592S		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTGCGACATCCAGAAACAGG	0.348													7	35					0	0	0.003080	0	0
KCNK5	8645	broad.mit.edu	37	6	39159183	39159183	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:39159183C>T	uc003oon.2	-	5	1347	c.983G>A	c.(982-984)GGG>GAG	p.G328E		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	328					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GCCTTGAGGCCCCAGCCCTGG	0.632													11	33					0	0	0.008291	0	0
KIF6	221458	broad.mit.edu	37	6	39693057	39693057	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:39693057C>T	uc003oot.2	-	1	125	c.30G>A	c.(28-30)GCG>GCA	p.A10A	KIF6_uc011dua.1_Silent_p.A10A|KIF6_uc010jxb.1_Silent_p.A10A	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	10	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GCTTCACCCTCGCGAATATCT	0.547													49	60					0	0	0.014410	0	0
TREML1	340205	broad.mit.edu	37	6	41117417	41117417	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:41117417C>T	uc011duc.1	-	6	905	c.861G>A	c.(859-861)CCG>CCA	p.P287P	TREML1_uc003opx.2_3'UTR|TREML1_uc011dud.1_Silent_p.P176P	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	287	Cytoplasmic (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGTTCCCTCCCGGGAAGATTA	0.537													28	34					0	0	0.007291	0	0
TREM1	54210	broad.mit.edu	37	6	41250298	41250298	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:41250298G>A	uc003oqf.1	-	2	305	c.241C>T	c.(241-243)CAA>TAA	p.Q81*	TREM1_uc003oqg.1_Nonsense_Mutation_p.Q81*	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	81	Extracellular (Potential).|Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	CTCCCCACTTGGACTGGATGG	0.498													40	21					0	0	0.009718	0	0
MDFI	4188	broad.mit.edu	37	6	41613945	41613945	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:41613945C>T	uc003oqp.3	+	4	487	c.158C>T	c.(157-159)TCC>TTC	p.S53F	MDFI_uc003oqq.3_Missense_Mutation_p.S53F|MDFI_uc010jxn.2_Missense_Mutation_p.S53F	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	53					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			GAGGAGGGCTCCCTGGAGGAG	0.627													16	19					0	0	0.006122	0	0
CUL7	9820	broad.mit.edu	37	6	43019484	43019484	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:43019484G>A	uc003otq.2	-	3	901	c.598C>T	c.(598-600)CTT>TTT	p.L200F	CUL7_uc011dvb.1_Missense_Mutation_p.L284F|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	200					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGTGACAGAAGGATCTGAGTC	0.498													40	40					0	0	0.010771	0	0
GPR116	221395	broad.mit.edu	37	6	46828470	46828470	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:46828470T>C	uc003oyo.3	-	16	2650	c.2361A>G	c.(2359-2361)GTA>GTG	p.V787V	GPR116_uc011dwj.1_Silent_p.V342V|GPR116_uc011dwk.1_Silent_p.V216V|GPR116_uc003oyp.3_Silent_p.V645V|GPR116_uc003oyq.3_Silent_p.V787V|GPR116_uc010jzi.1_Silent_p.V459V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	787	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TTTCTGAATTTACTTGGGTTG	0.418													10	35					0	0	0.008291	0	0
DEFB112	245915	broad.mit.edu	37	6	50016297	50016297	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:50016297G>A	uc011dws.1	-	1	68	c.68C>T	c.(67-69)TCC>TTC	p.S23F		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	23					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					AAATATTGTGGAAGATGTATT	0.333													24	43					0	0	0.006320	0	0
PKHD1	5314	broad.mit.edu	37	6	51656141	51656141	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:51656141G>A	uc003pah.1	-	53	8609	c.8333C>T	c.(8332-8334)CCA>CTA	p.P2778L	PKHD1_uc010jzn.1_Missense_Mutation_p.P761L|PKHD1_uc003pai.2_Missense_Mutation_p.P2778L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2778	G8 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TTTGAAGAATGGAAGATCTGT	0.453													4	21					0	0	0.009096	0	0
FAM83B	222584	broad.mit.edu	37	6	54806173	54806173	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:54806173A>G	uc003pck.2	+	5	2520	c.2404A>G	c.(2404-2406)AGT>GGT	p.S802G		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	802										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TAGATTGTGTAGTAGCTCTGA	0.363													5	42					0	0	0.003080	0	0
GFRAL	389400	broad.mit.edu	37	6	55216236	55216236	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:55216236T>C	uc003pcm.1	+	5	642	c.556T>C	c.(556-558)TTG>CTG	p.L186L		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	186	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGCCCAGATGTTGGCTTTTTG	0.438													38	49					0	0	0.006999	0	0
GFRAL	389400	broad.mit.edu	37	6	55223918	55223918	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:55223918C>T	uc003pcm.1	+	6	1020	c.934C>T	c.(934-936)CAT>TAT	p.H312Y		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	312	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GCACATGCTTCATAGAAAATC	0.279													16	25					0	0	0.004007	0	0
BMP5	653	broad.mit.edu	37	6	55625290	55625290	+	Missense_Mutation	SNP	C	T	T	rs147691986		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:55625290C>T	uc003pcq.2	-	5	1781	c.1069G>A	c.(1069-1071)GAA>AAA	p.E357K	BMP5_uc011dxf.1_Missense_Mutation_p.E357K	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	357					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACATAGAGTTCGTGCTTCTTA	0.348													9	39					0	0	0.008291	0	0
BAI3	577	broad.mit.edu	37	6	70064197	70064197	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:70064197C>T	uc003pev.3	+	27	3980	c.3532C>T	c.(3532-3534)CCT>TCT	p.P1178S	BAI3_uc010kak.2_Missense_Mutation_p.P1178S|BAI3_uc011dxx.1_Missense_Mutation_p.P384S	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1178	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GAGTTCGTTTCCTAATGGGCA	0.383													19	62					0	0	0.002780	0	0
IMPG1	3617	broad.mit.edu	37	6	76660521	76660521	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:76660521G>A	uc003pik.1	-	13	1712	c.1582C>T	c.(1582-1584)CCT>TCT	p.P528S		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	528					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GATGGGGCAGGAGTGTCAGAC	0.483													5	13					0	0	0.000602	0	0
C6orf162	57150	broad.mit.edu	37	6	88046794	88046794	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:88046794C>A	uc003plp.1	+	3	134	c.45C>A	c.(43-45)CCC>CCA	p.P15P	C6orf164_uc003plr.2_RNA|C6orf162_uc003plq.1_Silent_p.P15P	NM_001042493	NP_001035958	Q96KF7	CF162_HUMAN	hypothetical protein LOC57150	15						integral to membrane					0		all_cancers(76;3.81e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.3e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0164)		AGGAACCACCCAAAGAGAAAG	0.383													28	24					3.1745e-13	1.01459e-12	0.008361	1	0
GABRR1	2569	broad.mit.edu	37	6	89907954	89907954	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:89907954C>A	uc003pna.2	-	5	812	c.357G>T	c.(355-357)ACG>ACT	p.T119T	GABRR1_uc011dzv.1_Silent_p.T96T	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	119	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGAGGGTCATCGTAAAGTCCT	0.552													5	112					0.00116845	0.00367226	0.001168	1	0
SIM1	6492	broad.mit.edu	37	6	100841376	100841376	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:100841376G>A	uc003pqj.3	-	10	1764	c.1557C>T	c.(1555-1557)GTC>GTT	p.V519V	SIM1_uc010kcu.2_Silent_p.V519V	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	519	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGATCCTGTGGACTGAAGCGA	0.552													11	48					0	0	0.001855	0	0
SIM1	6492	broad.mit.edu	37	6	100841464	100841464	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:100841464C>T	uc003pqj.3	-	10	1676	c.1469G>A	c.(1468-1470)TGG>TAG	p.W490*	SIM1_uc010kcu.2_Nonsense_Mutation_p.W490*	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	490	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GCGAGAGCCCCACCAGGGCTC	0.607													28	17					0	0	0.007291	0	0
PREP	5550	broad.mit.edu	37	6	105730374	105730374	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:105730374G>A	uc003prc.2	-	13	1836	c.1633C>T	c.(1633-1635)CCC>TCC	p.P545S		NM_002726	NP_002717	P48147	PPCE_HUMAN	prolyl endopeptidase	545					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	AGCCTCTTGGGAGATGTGTAA	0.438													33	66					0	0	0.013726	0	0
ROS1	6098	broad.mit.edu	37	6	117631415	117631415	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:117631415G>A	uc003pxp.1	-	40	6462	c.6263C>T	c.(6262-6264)TCC>TTC	p.S2088F	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2088	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTCTTTCACGGAAACAAGGCA	0.368			T	GOPC|ROS1	glioblastoma|NSCLC								37	48					0	0	0.006999	0	0
PHACTR2	9749	broad.mit.edu	37	6	144081548	144081548	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:144081548A>C	uc003qjq.3	+	5	562	c.432A>C	c.(430-432)GAA>GAC	p.E144D	PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Missense_Mutation_p.E155D|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	144							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		AGAACACTGAAAACCACTCTG	0.463													5	4					0	0	0.000602	0	0
PDE10A	10846	broad.mit.edu	37	6	165832235	165832235	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:165832235G>A	uc003qun.2	-	12	1097	c.856C>T	c.(856-858)CGT>TGT	p.R286C	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R216C|PDE10A_uc003quo.2_Missense_Mutation_p.R296C	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	286	GAF 2.|Allosteric effector binding.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AGCGCACAACGATCGGCATTC	0.373													14	9					0	0	0.004007	0	0
MLLT4	4301	broad.mit.edu	37	6	168352852	168352852	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:168352852T>C	uc003qwd.2	+	29	4936	c.4794T>C	c.(4792-4794)GCT>GCC	p.A1598A	MLLT4_uc003qwb.1_Silent_p.A1583A|MLLT4_uc003qwc.1_Silent_p.A1599A|MLLT4_uc003qwg.1_Silent_p.A908A	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1599	Potential.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GCCTGGAGGCTGAACGAAGAG	0.413			T	MLL	AL								3	65					0	0	0.004672	0	0
GNA12	2768	broad.mit.edu	37	7	2771124	2771124	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:2771124G>A	uc003smu.2	-	4	1001	c.837C>T	c.(835-837)ACC>ACT	p.T279T	GNA12_uc011jwb.1_Silent_p.T262T|GNA12_uc003smt.2_Silent_p.T220T	NM_007353	NP_031379	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein)	279					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		TGTTGACGATGGTCTCGAAGA	0.537													39	37					0	0	0.004878	0	0
CARD11	84433	broad.mit.edu	37	7	2949686	2949686	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:2949686G>A	uc003smv.2	-	24	3662	c.3258C>T	c.(3256-3258)TTC>TTT	p.F1086F		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1086	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AGCCCTACCTGAACCTCTTGA	0.592			Mis		DLBCL								36	30					0	0	0.006999	0	0
SLC29A4	222962	broad.mit.edu	37	7	5331406	5331406	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:5331406C>T	uc003sod.2	+	5	659	c.498C>T	c.(496-498)TAC>TAT	p.Y166Y	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Silent_p.Y166Y|SLC29A4_uc003soe.2_Missense_Mutation_p.T154M	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	166	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		ACCAGGCCTACGCCATCAACC	0.637													31	20					0	0	0.006230	0	0
RAC1	5879	broad.mit.edu	37	7	6426906	6426906	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:6426906C>T	uc003spx.2	+	2	340	c.99C>T	c.(97-99)ATC>ATT	p.I33I	RAC1_uc003spw.2_Silent_p.I33I	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	33	Effector region (Potential).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GAGAATATATCCCTACTGTGT	0.358													49	50					0	0	0.014410	0	0
C7orf46	340277	broad.mit.edu	37	7	23724254	23724254	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:23724254C>T	uc003swo.3	+	2	291	c.202C>T	c.(202-204)CTT>TTT	p.L68F	C7orf46_uc003swq.3_Missense_Mutation_p.L68F|C7orf46_uc003swr.3_Intron|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587	A4D161	CG046_HUMAN	hypothetical protein LOC340277 isoform 1	68											0						GGATTGTAAACTTGTGGGCCC	0.348													25	19					0	0	0.006320	0	0
NPVF	64111	broad.mit.edu	37	7	25266264	25266264	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:25266264G>A	uc003sxo.2	-	2	567	c.520C>T	c.(520-522)CCC>TCC	p.P174S		NM_022150	NP_071433	Q9HCQ7	RFRP_HUMAN	neuropeptide VF precursor	174					neuropeptide signaling pathway	extracellular region|membrane	G-protein coupled receptor activity			ovary(1)	1						TTTTGATCGGGATTCTGGATT	0.413													19	95					0	0	0.012319	0	0
Unknown	0	broad.mit.edu	37	7	38370059	38370059	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:38370059C>T	uc010kxj.1	-	2	375	c.239G>A	c.(238-240)GGA>GAA	p.G80E	uc010kxk.1_RNA					SubName: Full=Putative uncharacterized protein ENSP00000374866;																		TCGACTGATTCCTGATTCCAA	0.458													11	46					0	0	0.013537	0	0
GLI3	2737	broad.mit.edu	37	7	42005316	42005316	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:42005316C>A	uc011kbh.1	-	15	3446	c.3355G>T	c.(3355-3357)GAC>TAC	p.D1119Y	GLI3_uc011kbg.1_Missense_Mutation_p.D1060Y	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1119					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACTTTGCTGTCGTCCGGGAGG	0.642									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				16	55					8.60227e-14	2.75321e-13	0.004007	1	0
PSMA2	5683	broad.mit.edu	37	7	42966224	42966224	+	Silent	SNP	G	A	A	rs150444926	byFrequency	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:42966224G>A	uc003thy.2	-	3	210	c.162C>T	c.(160-162)TCC>TCT	p.S54S	C7orf25_uc010kxr.2_Intron|PSMA2_uc010kxt.2_5'UTR|PSMA2_uc003thz.1_5'UTR	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	54					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						CATACAGAATGGATTTCTGTT	0.358													11	27					0	0	0.010729	0	0
POM121L12	285877	broad.mit.edu	37	7	53103409	53103409	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:53103409C>T	uc003tpz.2	+	1	61	c.45C>T	c.(43-45)TTC>TTT	p.F15F		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	15											0						TCGGGAACTTCTGGAAGGCGG	0.706													4	5					0	0	0.009096	0	0
POM121L12	285877	broad.mit.edu	37	7	53104126	53104126	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:53104126C>T	uc003tpz.2	+	1	778	c.762C>T	c.(760-762)TCC>TCT	p.S254S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	254											0						CTTGGCCTTCCGTGCTGGTCC	0.637													26	19					0	0	0.005443	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853302	70853302	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:70853302C>T	uc003tvy.2	+	3	504	c.504C>T	c.(502-504)ATC>ATT	p.I168I	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	168	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGTCGGTGATCCTGCGGTCCG	0.557													20	14					0	0	0.012319	0	0
WBSCR28	135886	broad.mit.edu	37	7	73279336	73279336	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:73279336G>A	uc003tzk.2	+	2	122	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	RFC2_uc011kfa.1_Intron|WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	hypothetical protein LOC135886	29						integral to membrane				breast(1)	1		Lung NSC(55;0.159)				GTTCAGAACCGAGATCACCTC	0.502													63	270					0	0	0.014410	0	0
CLIP2	7461	broad.mit.edu	37	7	73791003	73791003	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:73791003C>T	uc003uam.2	+	10	2599	c.2272C>T	c.(2272-2274)CTG>TTG	p.L758L	CLIP2_uc003uan.2_Silent_p.L723L|CLIP2_uc003uao.2_Silent_p.L152L	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	758	Potential.					microtubule associated complex				skin(3)	3						GCAGATCTCGCTGGCCGAGAA	0.627													12	38					0	0	0.001855	0	0
PCLO	27445	broad.mit.edu	37	7	82545849	82545849	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:82545849T>G	uc003uhx.2	-	7	11742	c.11453A>C	c.(11452-11454)AAG>ACG	p.K3818T	PCLO_uc003uhv.2_Missense_Mutation_p.K3818T|PCLO_uc010lec.2_Missense_Mutation_p.K783T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3749					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCGTTCTCTCTTTTCTCTCTC	0.453													40	37					0	0	0.006999	0	0
PCLO	27445	broad.mit.edu	37	7	82583366	82583366	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:82583366C>T	uc003uhx.2	-	5	7192	c.6903G>A	c.(6901-6903)GTG>GTA	p.V2301V	PCLO_uc003uhv.2_Silent_p.V2301V|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2232					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGCTTTCTTCACTGGGTCCT	0.408													22	131					0	0	0.002780	0	0
FZD1	8321	broad.mit.edu	37	7	90896063	90896063	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:90896063C>T	uc003ula.2	+	1	2281	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	623	Cytoplasmic (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGGATCTGGTCCGGCAAGACC	0.597													18	21					0	0	0.007413	0	0
AKAP9	10142	broad.mit.edu	37	7	91713966	91713966	+	Missense_Mutation	SNP	C	T	T	rs146689921		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:91713966C>T	uc003ulg.2	+	34	8884	c.8659C>T	c.(8659-8661)CCT>TCT	p.P2887S	AKAP9_uc003ulf.2_Missense_Mutation_p.P2879S|AKAP9_uc003uli.2_Missense_Mutation_p.P2510S|AKAP9_uc003ulj.2_Missense_Mutation_p.P657S|AKAP9_uc003ulk.2_Missense_Mutation_p.P162S	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATCCTCAATTCCTGAGCTAGC	0.299			T	BRAF	papillary thyroid								12	60					0	0	0.013537	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94881382	94881382	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:94881382G>T	uc003unp.2	+	11	2821	c.2539G>T	c.(2539-2541)GGG>TGG	p.G847W	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G869W|PPP1R9A_uc011kif.1_Missense_Mutation_p.G847W|PPP1R9A_uc003unq.2_Missense_Mutation_p.G847W|PPP1R9A_uc011kig.1_Missense_Mutation_p.G847W	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	847	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			AGTCTCTAAAGGGGATACCAT	0.408										HNSCC(28;0.073)			23	24					6.21321e-17	1.99139e-16	0.002780	1	0
ZAN	7455	broad.mit.edu	37	7	100348354	100348354	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:100348354C>T	uc003uwj.2	+	12	1521	c.1356C>T	c.(1354-1356)TTC>TTT	p.F452F	ZAN_uc003uwk.2_Silent_p.F452F|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	452	MAM 3.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCGTGGAGTTCGCATACCACA	0.597													5	12					0	0	0.001168	0	0
ZAN	7455	broad.mit.edu	37	7	100350705	100350705	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:100350705C>T	uc003uwj.2	+	14	3142	c.2977C>T	c.(2977-2979)CCC>TCC	p.P993S	ZAN_uc003uwk.2_Missense_Mutation_p.P993S|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	993	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCCACCATTCCCACAGAGAA	0.562													38	31					0	0	0.006230	0	0
Unknown	0	broad.mit.edu	37	7	100608884	100608884	+	Missense_Mutation	SNP	G	A	A	rs73163797	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:100608884G>A	uc003uxl.1	+	7	2763	c.1963G>A	c.(1963-1965)GCG>ACG	p.A655T	uc003uxm.1_RNA|uc003uxn.1_Intron|uc010lhn.1_RNA					SubName: Full=Intestinal mucin; Flags: Fragment;									p.A755T(1)									GAGCGGTCCCGCGTGTCGGTA	0.667													5	11					0	0	0.010729	0	0
MUC17	140453	broad.mit.edu	37	7	100677263	100677263	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:100677263C>T	uc003uxp.1	+	3	2619	c.2566C>T	c.(2566-2568)CCA>TCA	p.P856S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	856	Extracellular (Potential).|12.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.488													13	274					0	0	0.004990	0	0
PLOD3	8985	broad.mit.edu	37	7	100856396	100856396	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:100856396G>A	uc003uyd.2	-	7	1225	c.769C>T	c.(769-771)CCC>TCC	p.P257S	PLOD3_uc010lhs.2_5'Flank	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	257					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	ACCTTAGTGGGACCGTTTCCA	0.602													5	24					0	0	0.001984	0	0
CDHR3	222256	broad.mit.edu	37	7	105645017	105645017	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:105645017C>T	uc003vdl.3	+	8	1044	c.936C>T	c.(934-936)TCC>TCT	p.S312S	CDHR3_uc003vdk.2_5'UTR|CDHR3_uc011kls.1_RNA|CDHR3_uc003vdm.3_Silent_p.S299S|CDHR3_uc011klt.1_Silent_p.S224S|CDHR3_uc003vdn.2_Silent_p.S29S	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	312	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCACCATTTCCCTGGAAGTTC	0.483													14	15					0	0	0.003163	0	0
LAMB4	22798	broad.mit.edu	37	7	107692596	107692596	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:107692596C>T	uc010ljo.1	-	26	3946	c.3862G>A	c.(3862-3864)GAC>AAC	p.D1288N	LAMB4_uc003vey.2_Missense_Mutation_p.D1288N|LAMB4_uc010ljp.1_Missense_Mutation_p.D257N	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1288	Domain II.|Potential.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TCCTGAAGGTCTTCAAGTAAG	0.368													52	40					0	0	0.014410	0	0
LRRN3	54674	broad.mit.edu	37	7	110763912	110763912	+	Missense_Mutation	SNP	G	A	A	rs145461505		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:110763912G>A	uc003vft.3	+	4	2130	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.E362K|LRRN3_uc003vfs.3_Missense_Mutation_p.E362K	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	362	Extracellular (Potential).					integral to membrane		p.E362K(2)		skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AAACCTCAAGGAAATCAGCAT	0.463													13	40					0	0	0.001855	0	0
CALD1	800	broad.mit.edu	37	7	134625950	134625950	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:134625950C>T	uc003vrz.2	+	7	1953	c.1494C>T	c.(1492-1494)TTC>TTT	p.F498F	CALD1_uc003vry.2_Silent_p.F243F|CALD1_uc003vsa.2_Silent_p.F269F|CALD1_uc003vsb.2_Silent_p.F243F|CALD1_uc010lmm.2_Silent_p.F269F|CALD1_uc011kpt.1_Silent_p.F17F|CALD1_uc003vsc.2_Silent_p.F263F|CALD1_uc003vsd.2_Silent_p.F237F|CALD1_uc011kpu.1_Silent_p.F248F|CALD1_uc011kpv.1_Silent_p.F107F|CALD1_uc003vse.2_Silent_p.F362F	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	498					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						ATGGAGAATTCATGACCCACA	0.328													24	17					0	0	0.003954	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138444552	138444552	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:138444552C>T	uc003vuf.2	-	7	822	c.584G>A	c.(583-585)GGA>GAA	p.G195E	ATP6V0A4_uc003vug.2_Missense_Mutation_p.G195E|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.G195E	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	195	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						GTACACGTTTCCTCGGCAGAT	0.527													27	21					0	0	0.007291	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764752	138764752	+	Missense_Mutation	SNP	G	A	A	rs150932310		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:138764752G>A	uc003vun.2	-	4	1323	c.935C>T	c.(934-936)TCG>TTG	p.S312L	ZC3HAV1_uc003vuo.2_5'Flank|ZC3HAV1_uc003vup.2_Missense_Mutation_p.S312L	NM_020119	NP_064504	Q7Z2W4	ZCCHV_HUMAN	zinc finger antiviral protein isoform 1	312					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			ovary(1)	1						AGCCTTGGACGAGCCTGAGGG	0.587													29	26					0	0	0.005443	0	0
TTC26	79989	broad.mit.edu	37	7	138853101	138853101	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:138853101C>T	uc003vus.2	+	11	1077	c.963C>T	c.(961-963)CTC>CTT	p.L321L	TTC26_uc003vur.3_Silent_p.L321L|TTC26_uc011kqn.1_Silent_p.L321L|TTC26_uc011kqo.1_Silent_p.L290L|TTC26_uc011kqp.1_Silent_p.L216L|TTC26_uc003vut.2_Silent_p.L181L|TTC26_uc011kqq.1_Silent_p.L190L	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	321							binding			ovary(1)	1						AGTATATTCTCAAAGGAGTGG	0.363													8	31					0	0	0.003080	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				25	28					0	0	0.005443	0	0
AGK	55750	broad.mit.edu	37	7	141341053	141341053	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:141341053G>A	uc003vwi.2	+	12	903	c.732G>A	c.(730-732)TGG>TGA	p.W244*	AGK_uc011krg.1_Intron	NM_018238	NP_060708	Q53H12	AGK_HUMAN	acylglycerol kinase precursor	244					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)					AAAAGGAGTGGCCTCAGACTC	0.433													29	20					0	0	0.003755	0	0
MGAM	8972	broad.mit.edu	37	7	141758058	141758058	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:141758058G>T	uc003vwy.2	+	31	3803	c.3749G>T	c.(3748-3750)CGC>CTC	p.R1250L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1250	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGCTGTGTCGCTATGGCTAC	0.483													44	185					3.39706e-21	1.09033e-20	0.014410	1	0
PRSS1	5644	broad.mit.edu	37	7	142460761	142460761	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:142460761G>A	uc003wak.2	+	5	651	c.634G>A	c.(634-636)GGA>AGA	p.G212R	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.G152R	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	212	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ACAGCTCCAAGGAGTTGTCTC	0.502									Hereditary_Pancreatitis				44	19					0	0	0.011902	0	0
Unknown	0	broad.mit.edu	37	7	142498753	142498753	+	RNA	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:142498753G>A	uc011ksh.1	+	3		c.132G>A			uc011ksi.1_RNA|uc003vzw.1_RNA|uc010loj.1_RNA|uc003wad.2_RNA|uc003wag.1_3'UTR|uc003wbe.3_RNA|uc003wbf.3_RNA|uc003wbg.3_RNA|uc003wbh.3_Silent_p.E56E|uc003wbi.3_RNA|uc003wbj.3_RNA|uc003wbm.3_RNA|uc003wbn.3_RNA|uc010los.2_RNA					Homo sapiens mRNA for T-cell receptor beta chain, partial cds, clone:TCRVB.3.																		TCCCACCCGAGGTCGCTGTGT	0.567													9	40					0	0	0.006214	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146825806	146825806	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:146825806T>G	uc003weu.1	+	7	1477	c.961T>G	c.(961-963)TTC>GTC	p.F321V		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	321	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGGCATCCCTTTCTCTGGCAA	0.393										HNSCC(39;0.1)			16	62					0	0	0.004007	0	0
UBE3C	9690	broad.mit.edu	37	7	156967649	156967649	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:156967649C>T	uc010lqs.2	+	5	691	c.379C>T	c.(379-381)CTG>TTG	p.L127L	UBE3C_uc003wnf.2_Silent_p.L84L|UBE3C_uc003wng.2_Silent_p.L127L	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	127					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		ACACAGCTCTCTGTTTGTCAA	0.318													16	67					0	0	0.004007	0	0
DEFA1B	728358	broad.mit.edu	37	8	6873538	6873538	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:6873538C>T	uc003wqz.1	-	3	344	c.259G>A	c.(259-261)GGA>AGA	p.G87R		NM_005217	NP_005208	P59665	DEF1_HUMAN	defensin, alpha 3 preproprotein	87					chemotaxis|defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism|response to virus	extracellular space					0						CAGAGTCTTCCCTGGTAGATG	0.473													23	45					0	0	0.005443	0	0
NEIL2	252969	broad.mit.edu	37	8	11640909	11640909	+	Splice_Site	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:11640909G>A	uc003wug.2	+	4	1363	c.688_splice	c.e4+1	p.G230_splice	NEIL2_uc003wue.2_Splice_Site_p.G230_splice|NEIL2_uc003wuf.2_Splice_Site_p.G169_splice|NEIL2_uc011kxd.1_Splice_Site_p.G114_splice	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a						base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		TCAGGGCTAGGTATGACTCAT	0.338								BER_DNA_glycosylases					18	29					0	0	0.008871	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22862018	22862018	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:22862018C>T	uc003xcq.2	+	2	608	c.71C>T	c.(70-72)GCC>GTC	p.A24V	RHOBTB2_uc003xcp.2_Missense_Mutation_p.A46V|RHOBTB2_uc011kzp.1_Missense_Mutation_p.A31V	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	24	Rho-like.|GTP (Potential).				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		GGGGACAACGCCGTGGGTAAG	0.582											OREG0018628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	21					0	0	0.006214	0	0
ADAM28	10863	broad.mit.edu	37	8	24181448	24181448	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:24181448G>A	uc003xdy.2	+	9	905	c.822G>A	c.(820-822)GAG>GAA	p.E274E	ADAM28_uc003xdx.2_Silent_p.E274E|ADAM28_uc011kzz.1_Silent_p.E41E|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_5'Flank	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	274	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TCACCTTGGAGAATTTTTCTA	0.383													22	41					0	0	0.002780	0	0
CDCA2	157313	broad.mit.edu	37	8	25346122	25346122	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:25346122C>T	uc003xep.1	+	13	2067	c.1588C>T	c.(1588-1590)CAG>TAG	p.Q530*	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_Nonsense_Mutation_p.Q530*|CDCA2_uc003xeq.1_Nonsense_Mutation_p.Q515*|CDCA2_uc003xer.1_Nonsense_Mutation_p.Q193*	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	530					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TACAGAAGTTCAGCCTTGTAA	0.348													15	48					0	0	0.004007	0	0
TRIM35	23087	broad.mit.edu	37	8	27146715	27146715	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:27146715G>A	uc003xfl.1	-	5	950	c.868C>T	c.(868-870)CGC>TGC	p.R290C	TRIM35_uc010lup.1_Missense_Mutation_p.P250L	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	290	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		TTCCAGACGCGGTACTGCAGG	0.572													11	7					0	0	0.013537	0	0
RP1	6101	broad.mit.edu	37	8	55540771	55540771	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:55540771G>A	uc003xsd.1	+	4	4477	c.4329G>A	c.(4327-4329)CGG>CGA	p.R1443R	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1443					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGAACCACGGACTTCTGAAG	0.343													21	22					0	0	0.012319	0	0
CLVS1	157807	broad.mit.edu	37	8	62212784	62212784	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:62212784G>A	uc003xuh.2	+	2	722	c.398G>A	c.(397-399)CGA>CAA	p.R133Q	CLVS1_uc003xug.2_Missense_Mutation_p.R133Q|CLVS1_uc003xui.2_Intron|CLVS1_uc010lyp.2_Missense_Mutation_p.R133Q	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	133	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CTGGAAAACCGAGACCATTAC	0.458													14	32					0	0	0.004007	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68213613	68213613	+	Missense_Mutation	SNP	G	A	A	rs144506580		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:68213613G>A	uc003xxo.1	-	3	548	c.158C>T	c.(157-159)CCT>CTT	p.P53L		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	53					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCCATGAGGAGGACTAAATGA	0.299													17	49					0	0	0.008871	0	0
PREX2	80243	broad.mit.edu	37	8	69046488	69046488	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:69046488C>T	uc003xxv.1	+	32	3988	c.3961C>T	c.(3961-3963)CAG>TAG	p.Q1321*		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1321					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTTTCACTTTCAGTCACTTCT	0.438													19	45					0	0	0.007413	0	0
IL7	3574	broad.mit.edu	37	8	79710372	79710372	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:79710372C>T	uc003ybg.2	-	2	683	c.82G>A	c.(82-84)GAT>AAT	p.D28N	IL7_uc003ybe.2_5'UTR|IL7_uc011lfm.1_RNA|IL7_uc003ybh.2_RNA|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	28					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						CCTTCAATATCACAATCAGAT	0.343													16	44					0	0	0.003163	0	0
TMEM67	91147	broad.mit.edu	37	8	94828667	94828667	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:94828667G>A	uc011lgk.1	+	28	3046	c.2975G>A	c.(2974-2976)AGA>AAA	p.R992K	TMEM67_uc003yga.3_Missense_Mutation_p.R911K|TMEM67_uc011lgl.1_Missense_Mutation_p.R391K	NM_153704	NP_714915	Q5HYA8	MKS3_HUMAN	meckelin isoform 1	992					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding			ovary(2)	2	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			GTGGATCAAAGATTTTTGATT	0.274													37	62					0	0	0.006999	0	0
POP1	10940	broad.mit.edu	37	8	99162864	99162864	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:99162864A>T	uc003yij.3	+	14	2154	c.2054A>T	c.(2053-2055)AAA>ATA	p.K685I	POP1_uc011lgv.1_Missense_Mutation_p.K685I|POP1_uc003yik.2_Missense_Mutation_p.K685I	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	685					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GAAAAGTACAAAAGGTAAGAA	0.413													8	24					0	0	0.004482	0	0
ODF1	4956	broad.mit.edu	37	8	103573090	103573090	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:103573090C>T	uc003ykt.2	+	2	839	c.731C>T	c.(730-732)TCC>TTC	p.S244F		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	244					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			AGCCGATTTTCCTGTAGGAAG	0.323													30	67					0	0	0.003755	0	0
RIMS2	9699	broad.mit.edu	37	8	104898127	104898127	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:104898127C>T	uc003yls.2	+	2	875	c.634C>T	c.(634-636)CCT>TCT	p.P212S	RIMS2_uc003ylp.2_Missense_Mutation_p.P434S|RIMS2_uc003ylw.2_Missense_Mutation_p.P242S|RIMS2_uc003ylq.2_Missense_Mutation_p.P242S|RIMS2_uc003ylr.2_Missense_Mutation_p.P242S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	465					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCATAGTCCTCCTACCCCCAG	0.488										HNSCC(12;0.0054)			25	33					0	0	0.002780	0	0
CSMD3	114788	broad.mit.edu	37	8	113702234	113702234	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:113702234C>T	uc003ynu.2	-	14	2177	c.2018G>A	c.(2017-2019)GGA>GAA	p.G673E	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.G633E|CSMD3_uc011lhx.1_Missense_Mutation_p.G569E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	673	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTCTCTAATTCCATATAAGGG	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			88	145					0	0	0.014410	0	0
TRPS1	7227	broad.mit.edu	37	8	116616576	116616576	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:116616576G>A	uc003ynz.2	-	3	2040	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F	TRPS1_uc011lhy.1_Silent_p.F531F|TRPS1_uc003yny.2_Silent_p.F540F|TRPS1_uc010mcy.2_Silent_p.F527F	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	527					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GGAAGTCACAGAACTGACAAT	0.458									Langer-Giedion_syndrome				50	67					0	0	0.014410	0	0
SAMD12	401474	broad.mit.edu	37	8	119391770	119391770	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:119391770C>T	uc003yom.2	-	4	621	c.492G>A	c.(490-492)ATG>ATA	p.M164I	SAMD12_uc010mda.1_Intron|SAMD12_uc010mdb.1_Intron	NM_207506	NP_997389	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12 isoform	164										ovary(1)	1	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TCTCCCCATCCATCCACCCAT	0.423													31	32					0	0	0.009535	0	0
WDR67	93594	broad.mit.edu	37	8	124117616	124117616	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:124117616G>A	uc003ypp.1	+	8	1211	c.1121G>A	c.(1120-1122)AGA>AAA	p.R374K	WDR67_uc011lig.1_Missense_Mutation_p.R374K|WDR67_uc011lih.1_Missense_Mutation_p.R264K|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.R87K	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	374						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ACATCAGGGAGAGTACAGCAG	0.358													14	19					0	0	0.002450	0	0
ADCY8	114	broad.mit.edu	37	8	131916041	131916041	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:131916041C>T	uc003ytd.3	-	7	2144	c.1888G>A	c.(1888-1890)GAT>AAT	p.D630N	ADCY8_uc010mds.2_Missense_Mutation_p.D630N	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	630	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ACGATATTATCAAAGGGCAGT	0.507										HNSCC(32;0.087)			18	37					0	0	0.006122	0	0
TG	7038	broad.mit.edu	37	8	134128868	134128868	+	Silent	SNP	C	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:134128868C>A	uc003ytw.2	+	45	7811	c.7770C>A	c.(7768-7770)ATC>ATA	p.I2590I	TG_uc010mdw.2_Silent_p.I1349I|TG_uc011ljb.1_Silent_p.I959I|TG_uc011ljc.1_Silent_p.I723I	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2590					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACTTTATCATCTGCCCTATAA	0.537													18	48					3.08376e-08	9.78684e-08	0.003330	1	0
ZFAT	57623	broad.mit.edu	37	8	135521977	135521977	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:135521977G>A	uc003yup.2	-	15	3552	c.3377C>T	c.(3376-3378)CCC>CTC	p.P1126L	ZFAT_uc011ljj.1_Missense_Mutation_p.P245L|ZFAT_uc003yun.2_Missense_Mutation_p.P1114L|ZFAT_uc003yuo.2_Missense_Mutation_p.P1114L|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.P1114L|ZFAT_uc010mej.2_Missense_Mutation_p.P1064L	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CACGGCCGTGGGGTCCAGTCG	0.592													24	54					0	0	0.005443	0	0
FAM135B	51059	broad.mit.edu	37	8	139163712	139163712	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:139163712C>T	uc003yuy.2	-	13	3177	c.3006G>A	c.(3004-3006)GAG>GAA	p.E1002E	FAM135B_uc003yux.2_Silent_p.E903E|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.E564E|FAM135B_uc003yvb.2_Silent_p.E564E	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1002										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGCCTTCAGCTCTTGGTTTT	0.507										HNSCC(54;0.14)			15	39					0	0	0.002450	0	0
COL22A1	169044	broad.mit.edu	37	8	139626153	139626153	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:139626153C>T	uc003yvd.2	-	56	4382	c.3935G>A	c.(3934-3936)GGA>GAA	p.G1312E	COL22A1_uc011ljo.1_Missense_Mutation_p.G592E	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1312	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCAGTGGGTCCAGTGTCACC	0.498										HNSCC(7;0.00092)			37	66					0	0	0.008740	0	0
EPPK1	83481	broad.mit.edu	37	8	144945562	144945562	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:144945562G>A	uc003zaa.1	-	1	1873	c.1860C>T	c.(1858-1860)TCC>TCT	p.S620S		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	620	Plectin 11.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCGTTCCTGGGAGCCAGGGA	0.647													9	8					0	0	0.004482	0	0
EPPK1	83481	broad.mit.edu	37	8	144945889	144945889	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:144945889C>T	uc003zaa.1	-	1	1546	c.1533G>A	c.(1531-1533)TGG>TGA	p.W511*		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	511						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAGCAGCTCCCAGAGGGACA	0.652													11	9					0	0	0.010729	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145770733	145770733	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr8:145770733G>A	uc003zdt.1	-	7	2976	c.2421C>T	c.(2419-2421)CTC>CTT	p.L807L	ARHGAP39_uc011llk.1_Silent_p.L807L|ARHGAP39_uc003zds.1_Silent_p.L807L	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	807	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						AGATGGCCATGAGCTCCCAGC	0.637													15	24					0	0	0.003163	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786624	19786624	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:19786624C>T	uc003zoa.1	-	1	303	c.241G>A	c.(241-243)GGT>AGT	p.G81S	SLC24A2_uc003zob.1_Missense_Mutation_p.G81S	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	81	Extracellular (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TGATGGTAACCCTGTGCTACC	0.448													26	42					0	0	0.003954	0	0
TAF1L	138474	broad.mit.edu	37	9	32631964	32631964	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:32631964C>T	uc003zrg.1	-	1	3704	c.3614G>A	c.(3613-3615)CGA>CAA	p.R1205Q	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1205					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		AGCTGGTTTTCGGACTGTCTC	0.423													37	57					0	0	0.009718	0	0
PGM5P2	595135	broad.mit.edu	37	9	69127002	69127002	+	RNA	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:69127002C>T	uc004aff.3	-	2		c.565G>A				NR_002836				Homo sapiens phosphoglucomutase 5 pseudogene 2, mRNA (cDNA clone IMAGE:4121651), with apparent retained intron.												0						CCAAACTCTCCCCCTGGTCCT	0.438													6	9					0	0	0.004482	0	0
PRUNE2	158471	broad.mit.edu	37	9	79267526	79267526	+	Silent	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:79267526A>T	uc010mpk.2	-	11	8554	c.8430T>A	c.(8428-8430)CTT>CTA	p.L2810L	PRUNE2_uc011lsk.1_Silent_p.L59L|PRUNE2_uc011lsl.1_Silent_p.L74L|PRUNE2_uc011lsm.1_Silent_p.L74L|PRUNE2_uc004akj.3_Silent_p.L263L|PRUNE2_uc010mpl.1_Silent_p.L263L	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2810					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GGTCCAGAGAAAGATTGATAT	0.413													57	107					0	0	0.014410	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323836	79323836	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:79323836C>T	uc010mpk.2	-	8	3478	c.3354G>A	c.(3352-3354)GTG>GTA	p.V1118V		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1118					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CCTCCAAAATCACTCTGTTCC	0.517													37	68					0	0	0.007835	0	0
TLE1	7088	broad.mit.edu	37	9	84225190	84225190	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:84225190G>A	uc004aly.2	-	14	1717	c.1276C>T	c.(1276-1278)CAC>TAC	p.H426Y	TLE1_uc004alz.2_Missense_Mutation_p.H436Y|TLE1_uc011lsr.1_Missense_Mutation_p.H411Y|TLE1_uc004ama.1_Missense_Mutation_p.H425Y	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	426	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						ACTCTCATGTGAGGGGGAGGA	0.448													19	23					0	0	0.008871	0	0
GALNT12	79695	broad.mit.edu	37	9	101597641	101597641	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:101597641C>T	uc004ayz.2	+	5	1028	c.1028C>T	c.(1027-1029)TCC>TTC	p.S343F		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	343	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				CTCGAATTTTCCTTTAGGGTA	0.423													27	58					0	0	0.010818	0	0
COL15A1	1306	broad.mit.edu	37	9	101777808	101777808	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:101777808C>T	uc004azb.1	+	10	1669	c.1463C>T	c.(1462-1464)CCC>CTC	p.P488L		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	488	3.|Nonhelical region 1 (NC1).|4 X tandem repeats.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GGCCTGGCTCCCCTCACAGCC	0.562													7	12					0	0	0.004482	0	0
ALDOB	229	broad.mit.edu	37	9	104187776	104187776	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:104187776G>A	uc004bbk.2	-	7	840	c.758C>T	c.(757-759)ACC>ATC	p.T253I		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	253					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				AGCTGTTACGGTGGCCATAGC	0.507													30	61					0	0	0.012213	0	0
ABCA1	19	broad.mit.edu	37	9	107607828	107607828	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:107607828G>A	uc004bcl.2	-	8	1056	c.743C>T	c.(742-744)CCC>CTC	p.P248L	uc010mti.1_5'Flank	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	248	Extracellular.		P -> A.		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCTCGGGAAGGGAGATGTAGA	0.413													18	32					0	0	0.007413	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422088	115422088	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:115422088C>T	uc004bgf.1	+	4	2065	c.1890C>T	c.(1888-1890)TAC>TAT	p.Y630Y	KIAA1958_uc011lwx.1_Silent_p.Y658Y	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	630										skin(1)	1						AGTGCCCTTACTGCCTCCTCT	0.597													7	7					0	0	0.001984	0	0
COL27A1	85301	broad.mit.edu	37	9	116931602	116931602	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:116931602C>T	uc011lxl.1	+	3	1767	c.1767C>T	c.(1765-1767)GCC>GCT	p.A589A	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Silent_p.A439A	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	589	Pro-rich.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCACCCCGGCCCTGGTATTGG	0.652													15	35					0	0	0.004990	0	0
COL27A1	85301	broad.mit.edu	37	9	117072864	117072864	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:117072864C>T	uc011lxl.1	+	61	5472	c.5472C>T	c.(5470-5472)ACC>ACT	p.T1824T	COL27A1_uc004bii.2_RNA|COL27A1_uc011lxn.1_Silent_p.T139T	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1824	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CACTCTTCACCTTCCGGACCC	0.502													18	30					0	0	0.006122	0	0
AKNA	80709	broad.mit.edu	37	9	117099518	117099518	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:117099518G>T	uc004biq.3	-	21	4271	c.4136C>A	c.(4135-4137)CCA>CAA	p.P1379Q	AKNA_uc004bin.3_Missense_Mutation_p.P626Q|AKNA_uc004bio.3_Missense_Mutation_p.P839Q|AKNA_uc004bip.3_Missense_Mutation_p.P1298Q|AKNA_uc004bir.3_Missense_Mutation_p.P1379Q|AKNA_uc004bis.3_Missense_Mutation_p.P1379Q|AKNA_uc010mve.2_Missense_Mutation_p.P1260Q	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	1379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						CCGGGCTGGTGGGGGAGAGGC	0.657													14	27					3.51602e-12	1.12215e-11	0.008871	1	0
CEP110	11064	broad.mit.edu	37	9	123904444	123904444	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:123904444C>T	uc004bkx.1	+	17	2798	c.2767C>T	c.(2767-2769)CTA>TTA	p.L923L	CEP110_uc004bky.1_Silent_p.L527L|CEP110_uc004bla.1_Silent_p.L371L|CEP110_uc010mvo.1_5'Flank	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	923	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GCAAGAAAATCTAAAAAGTAT	0.378													18	21					0	0	0.007413	0	0
OR1J4	26219	broad.mit.edu	37	9	125281783	125281783	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:125281783C>T	uc011lyw.1	+	1	364	c.364C>T	c.(364-366)CGG>TGG	p.R122W		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCATACGATCGGTATGTGGC	0.433													34	58					0	0	0.012213	0	0
COQ4	51117	broad.mit.edu	37	9	131088065	131088065	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:131088065C>T	uc004bur.3	+	4	654	c.307C>T	c.(307-309)CCC>TCC	p.P103S	COQ4_uc011max.1_Missense_Mutation_p.P103S|COQ4_uc004bus.2_Missense_Mutation_p.P79S|COQ4_uc010mxy.2_Missense_Mutation_p.P79S	NM_016035	NP_057119	Q9Y3A0	COQ4_HUMAN	coenzyme Q4 homolog precursor	103					ubiquinone biosynthetic process	mitochondrial inner membrane					0						CAGGGAGCGTCCCCGGATTTC	0.597													7	24					0	0	0.004482	0	0
ODF2	4957	broad.mit.edu	37	9	131260847	131260847	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:131260847G>A	uc011mbd.1	+	19	2479	c.2168G>A	c.(2167-2169)AGG>AAG	p.R723K	ODF2_uc004bvb.2_Missense_Mutation_p.R699K|ODF2_uc011mbe.1_Missense_Mutation_p.R718K|ODF2_uc004bvc.2_Missense_Mutation_p.R699K|ODF2_uc004bvd.3_Missense_Mutation_p.R723K|ODF2_uc004bvh.2_Missense_Mutation_p.R129K	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	723	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						gaagatgcgaggaggcaggtc	0.194													5	9					0	0	0.000602	0	0
SNAPC4	6621	broad.mit.edu	37	9	139272358	139272358	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:139272358G>A	uc004chh.2	-	21	3930	c.3921C>T	c.(3919-3921)GCC>GCT	p.A1307A		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1307	SNAPC2-binding.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGCTGCACAGGGCTGGGGGCT	0.706													12	26					0	0	0.013537	0	0
ZBED1	9189	broad.mit.edu	37	X	2407161	2407161	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:2407161G>A	uc004cqg.2	-	2	1801	c.1600C>T	c.(1600-1602)CGG>TGG	p.R534W	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.R534W	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	534						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTGGATGTCCGCATGAGCTTC	0.652													13	6					0	0	0.004007	0	0
ARHGAP6	395	broad.mit.edu	37	X	11174717	11174717	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:11174717C>T	uc004cup.1	-	10	2712	c.1839G>A	c.(1837-1839)CTG>CTA	p.L613L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Silent_p.L613L|ARHGAP6_uc004cum.1_Silent_p.L410L|ARHGAP6_uc004cun.1_Silent_p.L433L|ARHGAP6_uc010neb.1_Silent_p.L435L|ARHGAP6_uc011mif.1_Silent_p.L410L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	613					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						ACAGGCTGATCAGCACTTCGT	0.448													20	4					0	0	0.002780	0	0
PIGA	5277	broad.mit.edu	37	X	15344095	15344095	+	Silent	SNP	T	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:15344095T>C	uc004cwr.2	-	3	889	c.789A>G	c.(787-789)GGA>GGG	p.G263G	PIGA_uc010neu.2_5'Flank|PIGA_uc004cwq.2_5'UTR|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_5'UTR|PIGA_uc011miq.1_Silent_p.G29G|PIGA_uc010new.1_3'UTR	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	263	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					TTGGTCCCTCTCCTCCAATTA	0.373													36	50					0	0	0.003271	0	0
FAM47B	170062	broad.mit.edu	37	X	34961290	34961290	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:34961290G>A	uc004ddi.1	+	1	360	c.342G>A	c.(340-342)CGG>CGA	p.R114R		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	114										ovary(3)|breast(1)	4						AGCCAGCACGGAAGGCGTTCG	0.532													31	26					0	0	0.010818	0	0
FAM47C	442444	broad.mit.edu	37	X	37026709	37026709	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:37026709T>A	uc004ddl.1	+	1	240	c.226T>A	c.(226-228)TTT>ATT	p.F76I		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	76										ovary(3)	3						CCGTGACGAGTTTTTACTCCC	0.527													16	15					0	0	0.004990	0	0
GAGE10	643832	broad.mit.edu	37	X	49173756	49173756	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:49173756G>A	uc010nir.1	+	4	433	c.317G>A	c.(316-318)AGG>AAG	p.R106K	GAGE10_uc010nis.2_RNA	NM_001098413	NP_001091883	A6NGK3	GAG10_HUMAN	G antigen 10	106											0	Ovarian(276;0.236)					GAGGTGAAAAGGCCTGAAGAA	0.443													80	40					0	0	0.014410	0	0
PFKFB1	5207	broad.mit.edu	37	X	54964045	54964045	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:54964045A>G	uc004dty.1	-	11	1282	c.1211T>C	c.(1210-1212)TTC>TCC	p.F404S	PFKFB1_uc010nkd.1_Missense_Mutation_p.F212S|PFKFB1_uc011mol.1_Missense_Mutation_p.F339S	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	404	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TTTATCCAGGAAATAGGCCAG	0.448													10	8					0	0	0.002450	0	0
GDPD2	54857	broad.mit.edu	37	X	69645640	69645640	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:69645640G>A	uc004dyh.2	+	4	488	c.237G>A	c.(235-237)TGG>TGA	p.W79*	GDPD2_uc010nkx.1_Nonsense_Mutation_p.W79*|GDPD2_uc010nky.1_Intron|GDPD2_uc011mpk.1_Nonsense_Mutation_p.W79*|GDPD2_uc011mpl.1_5'UTR|GDPD2_uc011mpm.1_5'UTR	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	79	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					GGGGACACTGGATGGACTGGT	0.617													23	13					0	0	0.008361	0	0
CHIC1	53344	broad.mit.edu	37	X	72797281	72797281	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:72797281C>T	uc004ebk.3	+	2	472	c.335C>T	c.(334-336)TCC>TTC	p.S112F	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_Missense_Mutation_p.S112F|CHIC1_uc004ebl.3_Missense_Mutation_p.S112F	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	112						cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					GAATTTCCCTCCGTTCTAACA	0.343													62	40					0	0	0.014410	0	0
AMOT	154796	broad.mit.edu	37	X	112058649	112058649	+	Silent	SNP	G	A	A	rs149397566	byFrequency	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:112058649G>A	uc004epr.2	-	2	1329	c.1329C>T	c.(1327-1329)GAC>GAT	p.D443D	AMOT_uc004eps.2_Silent_p.D34D|AMOT_uc004ept.1_Silent_p.D443D	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	443	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TCCGGTTCTCGTCTGAGAGGA	0.522													86	55					0	0	0.014410	0	0
CXorf61	203413	broad.mit.edu	37	X	115593954	115593954	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:115593954G>A	uc004eqj.1	-	1	184	c.64C>T	c.(64-66)CGC>TGC	p.R22C		NM_001017978	NP_001017978	Q5H943	KKLC1_HUMAN	chromosome X open reading frame 61	22	Extracellular (Potential).					integral to membrane|plasma membrane					0						TGAAAGCGGCGATATTTCCAG	0.428													34	30					0	0	0.006999	0	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760911	119760911	+	Silent	SNP	G	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:119760911G>A	uc004esy.2	-	3	458	c.111C>T	c.(109-111)CAC>CAT	p.H37H	C1GALT1C1_uc004esz.2_Silent_p.H37H	NM_152692	NP_689905	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	37	Lumenal (Potential).					integral to membrane					0						GCTCATGGTGGTGCATTCTAT	0.418													53	28					0	0	0.014410	0	0
SLC25A14	9016	broad.mit.edu	37	X	129474280	129474280	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:129474280A>T	uc004evn.1	+	2	241	c.28A>T	c.(28-30)ATT>TTT	p.I10F	SLC25A14_uc011mut.1_Intron|SLC25A14_uc011muu.1_Missense_Mutation_p.I10F|SLC25A14_uc010nrg.2_Missense_Mutation_p.I10F|SLC25A14_uc004evo.1_Intron|SLC25A14_uc004evp.1_Missense_Mutation_p.I10F|SLC25A14_uc004evq.1_Missense_Mutation_p.I10F|SLC25A14_uc004evr.1_Missense_Mutation_p.I10F	NM_003951	NP_003942	O95258	UCP5_HUMAN	solute carrier family 25, member 14 isoform	10					aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			ovary(1)	1						AATAATCCTAATTTTTCTAAG	0.498													27	23					0	0	0.012213	0	0
OR13H1	347468	broad.mit.edu	37	X	130678657	130678657	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:130678657T>G	uc011muw.1	+	1	610	c.610T>G	c.(610-612)TTC>GTC	p.F204V	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					CACCAGTATCTTCACCCTGCT	0.453													36	100					0	0	0.006230	0	0
GABRE	2564	broad.mit.edu	37	X	151123421	151123421	+	Missense_Mutation	SNP	C	T	T	rs150837963		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:151123421C>T	uc004ffi.2	-	9	1327	c.1273G>A	c.(1273-1275)GCC>ACC	p.A425T	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	425	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTGCTGGGCTGAGCAAGAC	0.602													7	4					0	0	0.003080	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303261	151303261	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:151303261C>T	uc004ffk.2	-	5	1240	c.832G>A	c.(832-834)GAA>AAA	p.E278K	MAGEA10_uc004ffl.2_Missense_Mutation_p.E278K	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	278	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGTAGTTTTCCTGCACCCAA	0.532													36	27					0	0	0.004289	0	0
FAM50A	9130	broad.mit.edu	37	X	153678387	153678387	+	Silent	SNP	C	T	T			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chrX:153678387C>T	uc004fll.3	+	11	938	c.840C>T	c.(838-840)TTC>TTT	p.F280F		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	280					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GACCACTCTTCAACTTTGATG	0.622											OREG0003609	type=REGULATORY REGION|Gene=FAM50A|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	17	17					0	0	0.004007	0	0
CAPN2	824	broad.mit.edu	37	1	223900573	223900573	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr1:223900573delC	uc001hob.3	+	1	455	c.231delC	c.(229-231)CGCfs	p.R77fs	CAPN2_uc010puy.1_Intron	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	77	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		AGTGGAAGCGCCCCACGGTAG	0.428													2	4	---	---	---	---					
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	-	-	rs3812754	byFrequency	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.432													4	2	---	---	---	---					
OR5D13	390142	broad.mit.edu	37	11	55541445	55541445	+	Frame_Shift_Del	DEL	A	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr11:55541445delA	uc010ril.1	+	1	532	c.532delA	c.(532-534)AATfs	p.N178fs		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CTTCATAAATAATTTTATCTG	0.408													16	48	---	---	---	---					
SLITRK5	26050	broad.mit.edu	37	13	88330160	88330161	+	Frame_Shift_Ins	INS	-	C	C			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr13:88330160_88330161insC	uc001vln.2	+	2	2736_2737	c.2517_2518insC	c.(2515-2520)GAGCCCfs	p.E839fs	SLITRK5_uc010tic.1_Frame_Shift_Ins_p.E598fs	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	839_840	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCACCATCGAGCCCCGGGAGGA	0.550													11	4	---	---	---	---					
TSHR	7253	broad.mit.edu	37	14	81609513	81609513	+	Frame_Shift_Del	DEL	A	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr14:81609513delA	uc001xvd.1	+	10	1267	c.1111delA	c.(1111-1113)AAAfs	p.K371fs		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	371	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CCAGGAGCTCAAAAACCCCCA	0.448			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						13	47	---	---	---	---					
C15orf21	283651	broad.mit.edu	37	15	45848231	45848231	+	RNA	DEL	T	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr15:45848231delT	uc010beg.1	+	6		c.1226delT			C15orf21_uc010beh.1_RNA|C15orf21_uc010bei.1_RNA|C15orf21_uc010bej.1_RNA|C15orf21_uc001zvm.1_RNA|C15orf21_uc001zvn.1_RNA					Homo sapiens cDNA FLJ39426 fis, clone PROST2000505.												0		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;3.03e-17)|GBM - Glioblastoma multiforme(94;7.36e-07)		TTTGTTTAGCTTTTTTTTTTT	0.323			T	ETV1	prostate								5	7	---	---	---	---					
BRCA1	672	broad.mit.edu	37	17	41244539	41244540	+	Frame_Shift_Del	DEL	AA	-	-	rs80357617		TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:41244539_41244540delAA	uc002icq.2	-	10	3240_3241	c.3008_3009delTT	c.(3007-3009)TTTfs	p.F1003fs	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Frame_Shift_Del_p.F932fs|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Frame_Shift_Del_p.F956fs|BRCA1_uc002ict.2_Frame_Shift_Del_p.F1003fs|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Frame_Shift_Del_p.F1003fs|BRCA1_uc002ide.1_Frame_Shift_Del_p.F834fs|BRCA1_uc010cyy.1_Frame_Shift_Del_p.F1003fs|BRCA1_uc010whs.1_Frame_Shift_Del_p.F1003fs|BRCA1_uc010cyz.2_Frame_Shift_Del_p.F956fs|BRCA1_uc010cza.2_Frame_Shift_Del_p.F977fs|BRCA1_uc010wht.1_Frame_Shift_Del_p.F707fs	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	1003					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AATGTTCCTCAAAGTTTTCCTC	0.332			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			24	89	---	---	---	---					
ANKFN1	162282	broad.mit.edu	37	17	54428180	54428181	+	Frame_Shift_Ins	INS	-	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr17:54428180_54428181insA	uc002iun.1	+	4	286_287	c.251_252insA	c.(250-252)TCAfs	p.S84fs		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	84										large_intestine(1)|ovary(1)	2						CTCTGTCAGTCAAAAAAACATA	0.426													17	31	---	---	---	---					
MCF2L2	23101	broad.mit.edu	37	3	182925526	182925547	+	Frame_Shift_Del	DEL	TCCTTCATTTTATAACGATCCT	-	-	rs139337758	by1000genomes	TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr3:182925526_182925547delTCCTTCATTTTATAACGATCCT	uc003fli.1	-	23	2651_2672	c.2561_2582delAGGATCGTTATAAAATGAAGGA	c.(2560-2583)AAGGATCGTTATAAAATGAAGGATfs	p.K854fs		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	854_861	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TCGAATCAAATCCTTCATTTTATAACGATCCTTGTGAATTGT	0.428													10	69	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:1019055_1019056delCA	uc003gce.2	+	7	1596_1597	c.1435_1436delCA	c.(1435-1437)CACfs	p.H479fs	FGFRL1_uc003gcf.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc003gcg.2_Frame_Shift_Del_p.H479fs|FGFRL1_uc010ibo.2_Frame_Shift_Del_p.H479fs	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.|Cytoplasmic (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.460													3	6	---	---	---	---					
KDR	3791	broad.mit.edu	37	4	55955941	55955941	+	Frame_Shift_Del	DEL	G	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr4:55955941delG	uc003has.2	-	24	3523	c.3221delC	c.(3220-3222)CCAfs	p.P1074fs	KDR_uc003hat.1_Frame_Shift_Del_p.P1074fs	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1074	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AATTGTTTCTGGGGCCATCCA	0.408			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			49	36	---	---	---	---					
BTN2A3	54718	broad.mit.edu	37	6	26428209	26428210	+	Frame_Shift_Ins	INS	-	A	A			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:26428209_26428210insA	uc011dkl.1	+	4	847_848	c.817_818insA	c.(817-819)GAAfs	p.E273fs	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						TCTCCAAAAGGAAAAAAAAGAT	0.416													7	46	---	---	---	---					
SLC35F1	222553	broad.mit.edu	37	6	118475765	118475765	+	Frame_Shift_Del	DEL	A	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr6:118475765delA	uc003pxx.3	+	2	532	c.331delA	c.(331-333)ACAfs	p.T111fs		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	111	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		CTATACCACCACACTAGCCGT	0.413													22	104	---	---	---	---					
SP8	221833	broad.mit.edu	37	7	20824941	20824943	+	In_Frame_Del	DEL	GCC	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:20824941_20824943delGCC	uc003suy.2	-	3	680_682	c.439_441delGGC	c.(439-441)GGCdel	p.G147del	SP8_uc003suz.2_In_Frame_Del_p.G165del	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						GCGCGGAGGAgccgccgccgccg	0.493													4	6	---	---	---	---					
NUP205	23165	broad.mit.edu	37	7	135262632	135262633	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr7:135262632_135262633delCT	uc003vsw.2	+	6	768_769	c.737_738delCT	c.(736-738)ACTfs	p.T246fs	NUP205_uc011kqa.1_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	246					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						AAAGAAGACACTCTCCTCCTCA	0.450													11	39	---	---	---	---					
LRSAM1	90678	broad.mit.edu	37	9	130248022	130248024	+	In_Frame_Del	DEL	GCA	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:130248022_130248024delGCA	uc004brb.1	+	17	1512_1514	c.1167_1169delGCA	c.(1165-1170)ATGCAG>ATG	p.Q391del	LRSAM1_uc010mxk.1_In_Frame_Del_p.Q391del|LRSAM1_uc004brc.1_In_Frame_Del_p.Q391del|LRSAM1_uc004brd.1_In_Frame_Del_p.Q391del|LRSAM1_uc004bre.1_Translation_Start_Site	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	391					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						CAGCCGCCATGCAGCAGATGCTG	0.591													21	35	---	---	---	---					
GBGT1	26301	broad.mit.edu	37	9	136029060	136029061	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-ER-A19G-06A-11D-A196-08	TCGA-ER-A19G-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	264eec6c-54a4-47f3-923e-83c31f5cd8d9	78cf4c7a-0349-4b30-9e1c-b4ad6ab9c07e	g.chr9:136029060_136029061delGG	uc004ccw.2	-	7	1228_1229	c.947_948delCC	c.(946-948)CCCfs	p.P316fs	RALGDS_uc011mcw.1_Intron|GBGT1_uc004ccx.2_Frame_Shift_Del_p.P269fs|GBGT1_uc010nab.2_3'UTR|GBGT1_uc011mcx.1_Frame_Shift_Del_p.P299fs|GBGT1_uc010nac.1_Frame_Shift_Del_p.P180fs|GBGT1_uc004ccy.1_3'UTR	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	316	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		AGAGGTACTCGGGGGACAGCAC	0.589													24	97	---	---	---	---					
