Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_status	validation_method	validation_tumor_sample	validation_alt_allele
MXRA8	54587	broad.mit.edu	37	1	1290110	1290110	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1290110delG	uc001aew.2	-	5	932	c.901delC	c.(901-903)CGGfs	p.R301fs	MXRA8_uc001aex.3_Frame_Shift_Del_p.R301fs|MXRA8_uc001aey.3_Frame_Shift_Del_p.R301fs|MXRA8_uc010nyl.1_Frame_Shift_Del_p.R301fs|MXRA8_uc001aez.2_Frame_Shift_Del_p.R200fs|MXRA8_uc001afa.2_Frame_Shift_Del_p.R292fs	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	301	Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)														---	---	---	---
PLCH2	9651	broad.mit.edu	37	1	2411479	2411479	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:2411479delG	uc001aji.1	+						PLCH2_uc010nyz.1_5'Flank|PLCH2_uc009vle.1_5'Flank|PLCH2_uc001ajj.1_5'Flank|PLCH2_uc001ajk.1_5'Flank	NM_014638	NP_055453			phospholipase C, eta 2						intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)														---	---	---	---
DFFB	1677	broad.mit.edu	37	1	3800152	3800152	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3800152delT	uc001alc.2	+	7	1187	c.864delT	c.(862-864)TATfs	p.Y288fs	DFFB_uc001ale.2_RNA|DFFB_uc009vlp.2_RNA|DFFB_uc001alb.2_RNA|DFFB_uc010nzn.1_Frame_Shift_Del_p.Y312fs|DFFB_uc009vlq.2_RNA|DFFB_uc009vlr.2_Frame_Shift_Del_p.Y239fs|DFFB_uc001ald.2_Frame_Shift_Del_p.Y224fs	NM_004402	NP_004393	O76075	DFFB_HUMAN	DNA fragmentation factor, 40 kD, beta	288					apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)														---	---	---	---
CHD5	26038	broad.mit.edu	37	1	6188045	6188045	+	Intron	DEL	G	-	-	rs3215558		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6188045delG	uc001amb.1	-						CHD5_uc001alz.1_Intron|CHD5_uc001ama.1_Intron|CHD5_uc001amc.1_Intron|CHD5_uc009vlx.1_Intron	NM_015557	NP_056372			chromodomain helicase DNA binding protein 5						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)														---	---	---	---
RPL22	6146	broad.mit.edu	37	1	6257785	6257785	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6257785delT	uc001amd.2	-	2	90	c.44delA	c.(43-45)AAGfs	p.K15fs	RPL22_uc001ame.2_Frame_Shift_Del_p.K15fs	NM_000983	NP_000974	P35268	RL22_HUMAN	ribosomal protein L22 proprotein	15					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|RNA binding|structural constituent of ribosome				0	Ovarian(185;0.0634)	all_cancers(23;2.78e-38)|all_epithelial(116;8.88e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.53e-38)|GBM - Glioblastoma multiforme(13;3.33e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.8e-19)|Colorectal(212;6.8e-08)|COAD - Colon adenocarcinoma(227;8.04e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)				T	RUNX1	AML|CML								---	---	---	---
THAP3	90326	broad.mit.edu	37	1	6693977	6693977	+	Intron	DEL	A	-	-	rs3215503		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6693977delA	uc001aoe.1	+							NM_138350	NP_612359			THAP domain containing, apoptosis associated								DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)														---	---	---	---
PARK7	11315	broad.mit.edu	37	1	8025311	8025311	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8025311delT	uc001aou.3	+						PARK7_uc001aow.3_Intron|PARK7_uc001aox.3_Intron|PARK7_uc001aov.3_Intron	NM_001123377	NP_001116849			Parkinson disease protein 7						autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity				0	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
RERE	473	broad.mit.edu	37	1	8616682	8616683	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8616682_8616683insA	uc001ape.2	-						RERE_uc001apf.2_Intron|RERE_uc001aph.1_Intron	NM_012102	NP_036234			atrophin-1 like protein isoform a						multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)														---	---	---	---
MTOR	2475	broad.mit.edu	37	1	11187619	11187619	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11187619delT	uc001asd.2	-						MTOR_uc001asc.2_Intron	NM_004958	NP_004949			FK506 binding protein 12-rapamycin associated						cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29																		---	---	---	---
VPS13D	55187	broad.mit.edu	37	1	12316748	12316751	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:12316748_12316751delTTTT	uc001atv.2	+						VPS13D_uc001atw.2_Intron	NM_015378	NP_056193			vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)														---	---	---	---
PRAMEF5	343068	broad.mit.edu	37	1	13012832	13012832	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13012832delA	uc001aur.2	-							NM_001013407	NP_001013425			PRAME family member 5												0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF17	391004	broad.mit.edu	37	1	13719052	13719052	+	3'UTR	DEL	T	-	-	rs141370897	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13719052delT	uc009vnz.1	+	3						NM_001099851	NP_001093321			PRAME family member 17												0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;9.86e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|COAD - Colon adenocarcinoma(227;0.000502)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TMEM51	55092	broad.mit.edu	37	1	15518958	15518958	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15518958delT	uc001avw.3	+						TMEM51_uc010obk.1_Intron|TMEM51_uc001avz.2_Intron|TMEM51_uc001avy.2_Intron|TMEM51_uc001avx.2_Intron	NM_001136216	NP_001129688			transmembrane protein 51							integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)														---	---	---	---
SPEN	23013	broad.mit.edu	37	1	16248727	16248730	+	Intron	DEL	TCTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16248727_16248730delTCTT	uc001axk.1	+						SPEN_uc010obp.1_Intron	NM_015001	NP_055816			spen homolog, transcriptional regulator						interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)														---	---	---	---
SPATA21	374955	broad.mit.edu	37	1	16725948	16725950	+	In_Frame_Del	DEL	TCT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16725948_16725950delTCT	uc001ayn.2	-	12	1724_1726	c.1241_1243delAGA	c.(1240-1245)AAGATG>ATG	p.K414del	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_In_Frame_Del_p.K391del	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	414							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)														---	---	---	---
NECAP2	55707	broad.mit.edu	37	1	16785155	16785155	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:16785155delA	uc001ayo.2	+						NECAP2_uc001ayp.3_Intron|NECAP2_uc010ocd.1_Intron|NECAP2_uc001ayq.2_Intron	NM_018090	NP_060560			NECAP endocytosis associated 2 isoform 1						endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CROCC	9696	broad.mit.edu	37	1	17299013	17299014	+	3'UTR	DEL	CA	-	-	rs6661019	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17299013_17299014delCA	uc001azt.2	+	37					CROCC_uc001azu.2_3'UTR|CROCC_uc001azv.2_3'UTR	NM_014675	NP_055490			ciliary rootlet coiled-coil						cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	17345217	17345217	+	IGR	DEL	T	-	-	rs75557632		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17345217delT								ATP13A2 (6794 upstream) : SDHB (10 downstream)																																			---	---	---	---
SDHB	6390	broad.mit.edu	37	1	17371412	17371412	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17371412delA	uc001bae.2	-							NM_003000	NP_002991			succinate dehydrogenase complex, subunit B, iron						respiratory electron transport chain|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	2 iron, 2 sulfur cluster binding|3 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|protein binding|succinate dehydrogenase (ubiquinone) activity|ubiquinone binding			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0049)|COAD - Colon adenocarcinoma(227;1.18e-05)|BRCA - Breast invasive adenocarcinoma(304;2.41e-05)|Kidney(64;0.000188)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)	Succinic acid(DB00139)			Mis|N|F			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	1	20246778	20246778	+	IGR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20246778delG								OTUD3 (7349 upstream) : PLA2G2E (22 downstream)																																			---	---	---	---
DDOST	1650	broad.mit.edu	37	1	20981868	20981868	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20981868delA	uc001bdo.1	-						DDOST_uc009vpw.1_Intron|DDOST_uc010odd.1_Intron|DDOST_uc010ode.1_Intron	NM_005216	NP_005207			dolichyl-diphosphooligosaccharide-protein						innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
EIF4G3	8672	broad.mit.edu	37	1	21151745	21151751	+	Intron	DEL	AAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21151745_21151751delAAAAAAA	uc001bec.2	-						EIF4G3_uc010odi.1_Intron|EIF4G3_uc010odj.1_Intron|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Intron|EIF4G3_uc001bef.2_Intron|EIF4G3_uc001bee.2_Intron	NM_003760	NP_003751			eukaryotic translation initiation factor 4						interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)														---	---	---	---
EIF4G3	8672	broad.mit.edu	37	1	21188703	21188703	+	Intron	DEL	A	-	-	rs10916885	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21188703delA	uc001bec.2	-						EIF4G3_uc010odi.1_Intron|EIF4G3_uc010odj.1_Intron|EIF4G3_uc009vpz.2_Intron|EIF4G3_uc001bed.2_Intron|EIF4G3_uc001bef.2_Intron|EIF4G3_uc001bee.2_Intron	NM_003760	NP_003751			eukaryotic translation initiation factor 4						interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)														---	---	---	---
ECE1	1889	broad.mit.edu	37	1	21553520	21553520	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21553520delT	uc001bek.2	-						ECE1_uc001bem.2_Intron|ECE1_uc001bej.2_Intron|ECE1_uc001bei.2_Intron|ECE1_uc010odl.1_Intron	NM_001397	NP_001388			endothelin converting enzyme 1 isoform 1						bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)														---	---	---	---
ALPL	249	broad.mit.edu	37	1	21889689	21889689	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21889689delG	uc001bet.2	+	5	641	c.384delG	c.(382-384)GTGfs	p.V128fs	ALPL_uc010odn.1_Frame_Shift_Del_p.V76fs|ALPL_uc010odo.1_Frame_Shift_Del_p.V73fs|ALPL_uc010odp.1_Frame_Shift_Del_p.V51fs|ALPL_uc001beu.3_Frame_Shift_Del_p.V128fs	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	128			V -> M (in HOPS).		response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)													---	---	---	---
USP48	84196	broad.mit.edu	37	1	22021456	22021456	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22021456delA	uc001bfb.2	-						USP48_uc001bfa.2_Intron|USP48_uc010odq.1_Intron|USP48_uc009vqc.2_Intron|USP48_uc001bfc.2_Intron|USP48_uc001bfd.1_Intron	NM_032236	NP_115612			ubiquitin specific protease 48 isoform a						ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)														---	---	---	---
HSPG2	3339	broad.mit.edu	37	1	22211642	22211642	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22211642delG	uc001bfj.2	-	11	1259	c.1219delC	c.(1219-1221)CAGfs	p.Q407fs	HSPG2_uc009vqd.2_Frame_Shift_Del_p.Q407fs	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	407	Ig-like C2-type 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)													---	---	---	---
EPHA8	2046	broad.mit.edu	37	1	22928009	22928009	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22928009delG	uc001bfx.1	+							NM_020526	NP_065387			ephrin receptor EphA8 isoform 1 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)														---	---	---	---
HNRNPR	10236	broad.mit.edu	37	1	23650294	23650294	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23650294delT	uc001bgr.3	-						HNRNPR_uc001bgp.3_Intron|HNRNPR_uc009vqk.2_Intron|HNRNPR_uc001bgs.3_Intron|HNRNPR_uc010odw.1_Intron|HNRNPR_uc010odx.1_Intron|HNRNPR_uc009vql.2_Intron	NM_005826	NP_005817			heterogeneous nuclear ribonucleoprotein R							catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
HMGCL	3155	broad.mit.edu	37	1	24147174	24147176	+	Intron	DEL	TAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24147174_24147176delTAA	uc001bib.2	-						HMGCL_uc010oec.1_Intron|HMGCL_uc009vqr.2_Intron|HMGCL_uc001bic.2_Intron|HMGCL_uc009vqs.1_Intron|HMGCL_uc001bid.1_Intron	NM_000191	NP_000182			3-hydroxy-3-methylglutaryl CoA lyase isoform 1						acetoacetic acid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA lyase activity|metal ion binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.0044)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.38e-24)|Colorectal(126;5.58e-08)|COAD - Colon adenocarcinoma(152;3.12e-06)|GBM - Glioblastoma multiforme(114;4.9e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000982)|KIRC - Kidney renal clear cell carcinoma(1967;0.0034)|STAD - Stomach adenocarcinoma(196;0.0128)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0856)|LUSC - Lung squamous cell carcinoma(448;0.188)														---	---	---	---
SYF2	25949	broad.mit.edu	37	1	25554441	25554441	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:25554441delT	uc001bjt.1	-						SYF2_uc001bju.1_Intron|SYF2_uc010oeo.1_Intron	NM_015484	NP_056299			SYF2 homolog, RNA splicing factor isoform 1							catalytic step 2 spliceosome					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)														---	---	---	---
MAN1C1	57134	broad.mit.edu	37	1	26104704	26104704	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26104704delG	uc001bkm.2	+	9	1696	c.1366delG	c.(1366-1368)GGGfs	p.G456fs	MAN1C1_uc009vry.1_Frame_Shift_Del_p.G276fs|MAN1C1_uc001bkn.2_5'Flank	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	456	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)														---	---	---	---
ZNF683	257101	broad.mit.edu	37	1	26694028	26694028	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26694028delC	uc001bmg.1	-						ZNF683_uc001bmh.1_Intron|ZNF683_uc009vsj.1_Intron	NM_173574	NP_775845			zinc finger protein 683						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)														---	---	---	---
ARID1A	8289	broad.mit.edu	37	1	27059207	27059207	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27059207delC	uc001bmv.1	+	4	2217	c.1844delC	c.(1843-1845)GCCfs	p.A615fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.A615fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.A615fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.A232fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	615					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)				Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---	---
ARID1A	8289	broad.mit.edu	37	1	27097622	27097622	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27097622delA	uc001bmv.1	+	12	3584	c.3211delA	c.(3211-3213)AAAfs	p.K1071fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.K1071fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.K1071fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.K688fs|ARID1A_uc001bmx.1_5'UTR|ARID1A_uc009vsm.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1071	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.K1072fs*21(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)				Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								---	---	---	---
WDTC1	23038	broad.mit.edu	37	1	27622800	27622801	+	Intron	INS	-	C	C	rs78037021		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27622800_27622801insC	uc009vst.2	+						WDTC1_uc001bno.2_Intron|WDTC1_uc001bnp.1_Intron|WDTC1_uc001bnq.2_5'Flank	NM_015023	NP_055838			WD and tetratricopeptide repeats 1								protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)														---	---	---	---
TMEM222	84065	broad.mit.edu	37	1	27657319	27657319	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27657319delG	uc001bnr.3	+						TMEM222_uc001bns.3_Intron|TMEM222_uc001bnt.3_Intron|TMEM222_uc001bnu.3_Intron	NM_032125	NP_115501			transmembrane protein 222							integral to membrane	protein binding				0																		---	---	---	---
WASF2	10163	broad.mit.edu	37	1	27745045	27745045	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27745045delT	uc001bof.1	-						WASF2_uc010ofl.1_Intron	NM_006990	NP_008921			WAS protein family, member 2						actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)														---	---	---	---
PHACTR4	65979	broad.mit.edu	37	1	28817970	28817970	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28817970delA	uc001bpw.2	+						PHACTR4_uc001bpv.1_Intron|PHACTR4_uc001bpx.2_Intron|PHACTR4_uc001bpy.2_Intron|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648			phosphatase and actin regulator 4 isoform 1								actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TAF12	6883	broad.mit.edu	37	1	28929962	28929962	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28929962delA	uc001bqw.2	-	5					TAF12_uc001bqx.2_3'UTR|TAF12_uc001bqy.2_3'UTR	NM_005644	NP_005635			TAF12 RNA polymerase II, TATA box binding						histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29064942	29064942	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29064942delT	uc001brc.2	+						YTHDF2_uc001brd.2_Intron|YTHDF2_uc010ofx.1_Intron|YTHDF2_uc001bre.2_Intron	NM_016258	NP_057342			high glucose-regulated protein 8						humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
SFRS4	6429	broad.mit.edu	37	1	29476547	29476547	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29476547delA	uc001bro.2	-						SFRS4_uc010ofy.1_Intron	NM_005626	NP_005617			splicing factor, arginine/serine-rich 4						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)														---	---	---	---
SFRS4	6429	broad.mit.edu	37	1	29481429	29481429	+	Intron	DEL	A	-	-	rs66504457		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29481429delA	uc001bro.2	-						SFRS4_uc010ofy.1_Intron|SFRS4_uc009vtp.2_Intron	NM_005626	NP_005617			splicing factor, arginine/serine-rich 4						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding				0		Colorectal(325;0.00161)|Breast(348;0.0364)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0529)|Lung NSC(340;0.0654)|all_lung(284;0.074)|Ovarian(437;0.104)|Medulloblastoma(700;0.151)		Colorectal(126;1.01e-07)|COAD - Colon adenocarcinoma(152;6.21e-06)|STAD - Stomach adenocarcinoma(196;0.0196)|BRCA - Breast invasive adenocarcinoma(304;0.0531)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.138)														---	---	---	---
TINAGL1	64129	broad.mit.edu	37	1	32051207	32051208	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32051207_32051208insC	uc001bta.2	+						TINAGL1_uc001bsz.2_Intron|TINAGL1_uc010ogj.1_Intron|TINAGL1_uc010ogk.1_Intron	NM_022164	NP_071447			tubulointerstitial nephritis antigen-like 1						endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)														---	---	---	---
EIF3I	8668	broad.mit.edu	37	1	32691629	32691629	+	Intron	DEL	A	-	-	rs74686229		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32691629delA	uc001bur.3	+						EIF3I_uc009vuc.2_Intron|EIF3I_uc001bus.2_Intron	NM_003757	NP_003748			eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)																---	---	---	---
RBBP4	5928	broad.mit.edu	37	1	33117785	33117785	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33117785delT	uc001bvr.2	+						ZBTB8OS_uc001bvo.1_5'Flank|ZBTB8OS_uc001bvp.2_5'Flank|ZBTB8OS_uc001bvq.2_5'Flank|RBBP4_uc001bvs.2_Intron|RBBP4_uc010ohj.1_Intron|RBBP4_uc010ohk.1_Intron	NM_005610	NP_005601			retinoblastoma binding protein 4 isoform a						cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)																---	---	---	---
DLGAP3	58512	broad.mit.edu	37	1	35370731	35370731	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35370731delC	uc001byc.2	-	1	254	c.254delG	c.(253-255)GGTfs	p.G85fs		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	85					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)																---	---	---	---
ZMYM6	9204	broad.mit.edu	37	1	35480538	35480538	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35480538delA	uc001byh.2	-						ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Intron|ZMYM6_uc009vup.2_Intron|ZMYM6_uc009vuq.1_Intron|ZMYM6_uc009vur.1_Intron	NM_007167	NP_009098			zinc finger protein 258						multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)																---	---	---	---
ZMYM1	79830	broad.mit.edu	37	1	35577760	35577760	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:35577760delT	uc001bym.2	+						ZMYM1_uc001byn.2_Intron|ZMYM1_uc010ohu.1_Intron|ZMYM1_uc001byo.2_Intron|ZMYM1_uc009vut.2_Intron	NM_024772	NP_079048			zinc finger, MYM domain containing 1							nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
KIAA0319L	79932	broad.mit.edu	37	1	36019914	36019914	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36019914delA	uc001byx.2	-						KIAA0319L_uc010ohw.1_Intron|KIAA0319L_uc001byz.2_Intron|KIAA0319L_uc010ohx.1_Intron	NM_024874	NP_079150			dyslexia susceptibility 2-like							cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
CLSPN	63967	broad.mit.edu	37	1	36208989	36208989	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36208989delA	uc001bzi.2	-						CLSPN_uc009vux.2_Intron	NM_022111	NP_071394			claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
EIF2C3	192669	broad.mit.edu	37	1	36411499	36411499	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36411499delT	uc001bzp.2	+						EIF2C3_uc001bzn.1_Intron|EIF2C3_uc001bzo.2_Intron|EIF2C3_uc001bzq.2_Intron	NM_024852	NP_079128			eukaryotic translation initiation factor 2C, 3						mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
EIF2C3	192669	broad.mit.edu	37	1	36479150	36479150	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36479150delA	uc001bzp.2	+						EIF2C3_uc001bzq.2_Intron	NM_024852	NP_079128			eukaryotic translation initiation factor 2C, 3						mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)																---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39798936	39798936	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39798936delA	uc010oiu.1	+	1	2127	c.1996delA	c.(1996-1998)AAAfs	p.K666fs	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2231					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
PABPC4	8761	broad.mit.edu	37	1	40031207	40031208	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40031207_40031208insA	uc010oiv.1	-						PABPC4_uc001cdl.2_Intron|PABPC4_uc001cdm.2_Intron	NM_003819	NP_003810			poly A binding protein, cytoplasmic 4 isoform 2						blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)															---	---	---	---
MFSD2A	84879	broad.mit.edu	37	1	40434360	40434361	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:40434360_40434361delTG	uc001cev.2	+	13	1692_1693	c.1511_1512delTG	c.(1510-1512)ATGfs	p.M504fs	MFSD2A_uc010ojb.1_Frame_Shift_Del_p.M452fs|MFSD2A_uc001ceu.2_Frame_Shift_Del_p.M491fs|MFSD2A_uc010ojc.1_Frame_Shift_Del_p.M335fs|MFSD2A_uc009vvy.2_RNA|MFSD2A_uc001cex.2_Frame_Shift_Del_p.M155fs	NM_001136493	NP_001129965	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing	504					transmembrane transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)|pancreas(1)	2																		---	---	---	---
PPCS	79717	broad.mit.edu	37	1	42925658	42925658	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:42925658delA	uc001chl.2	+	3					PPCS_uc001chk.2_3'UTR	NM_024664	NP_078940			phosphopantothenoylcysteine synthetase isoform						coenzyme biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenate--cysteine ligase activity				0	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
SLC2A1	6513	broad.mit.edu	37	1	43393009	43393009	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43393009delA	uc001cik.2	-							NM_006516	NP_006507			solute carrier family 2 (facilitated glucose						carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)													---	---	---	---
RNF220	55182	broad.mit.edu	37	1	45116581	45116582	+	3'UTR	INS	-	AC	AC			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45116581_45116582insAC	uc001clv.1	+	15					RNF220_uc001clw.1_3'UTR|RNF220_uc010oky.1_3'UTR|RNF220_uc010okz.1_3'UTR|RNF220_uc001clx.1_3'UTR|RNF220_uc001cly.1_3'UTR|RNF220_uc001clz.1_3'UTR|RNF220_uc001cma.1_3'UTR|TMEM53_uc001cmb.1_Intron	NM_018150	NP_060620			ring finger protein 220						protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
PLK3	1263	broad.mit.edu	37	1	45267504	45267505	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45267504_45267505delTT	uc001cmn.2	+						PLK3_uc001cmo.2_Intron	NM_004073	NP_004064			polo-like kinase 3							membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
EIF2B3	8891	broad.mit.edu	37	1	45392451	45392451	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45392451delT	uc001cmt.1	-						EIF2B3_uc001cmu.1_Intron|EIF2B3_uc001cmv.1_Intron|EIF2B3_uc001cmw.2_Intron	NM_020365	NP_065098			eukaryotic translation initiation factor 2B,						negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
TESK2	10420	broad.mit.edu	37	1	45821220	45821220	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45821220delT	uc001cns.1	-						TESK2_uc009vxr.1_Intron|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_Intron	NM_007170	NP_009101			testis-specific protein kinase 2						actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
TESK2	10420	broad.mit.edu	37	1	45880632	45880632	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45880632delA	uc001cns.1	-						TESK2_uc009vxr.1_Intron|TESK2_uc010olo.1_Intron|TESK2_uc009vxs.1_Intron|TESK2_uc010olp.1_Intron	NM_007170	NP_009101			testis-specific protein kinase 2						actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
GPBP1L1	60313	broad.mit.edu	37	1	46120606	46120606	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46120606delA	uc001coq.2	-							NM_021639	NP_067652			GC-rich promoter binding protein 1-like 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
POMGNT1	55624	broad.mit.edu	37	1	46655770	46655774	+	Intron	DEL	TTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:46655770_46655774delTTTTT	uc001cpe.2	-						POMGNT1_uc010olx.1_Intron|POMGNT1_uc010oly.1_Intron|POMGNT1_uc010olz.1_Intron|POMGNT1_uc001cpg.2_Intron|POMGNT1_uc001cpf.2_Intron	NM_017739	NP_060209			O-linked mannose						protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
MKNK1	8569	broad.mit.edu	37	1	47037894	47037895	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47037894_47037895insT	uc001cqb.2	-						MKNK1_uc010omd.1_Intron|MKNK1_uc001cqc.2_Intron|MKNK1_uc009vyi.2_Intron|MKNK1_uc010ome.1_Intron|MKNK1_uc009vyj.2_Intron|MKNK1_uc001cqd.2_Intron	NM_003684	NP_003675			MAP kinase-interacting serine/threonine kinase 1						intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
CYP4Z2P	163720	broad.mit.edu	37	1	47339124	47339125	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:47339124_47339125insC	uc001cqo.1	-						CYP4Z2P_uc009vyn.1_Intron	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	50864446	50864446	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:50864446delT								ELAVL4 (196906 upstream) : DMRTA2 (18783 downstream)																																			---	---	---	---
FAF1	11124	broad.mit.edu	37	1	51204722	51204722	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51204722delT	uc009vyx.1	-						FAF1_uc009vyw.1_Intron|FAF1_uc001cse.1_Intron	NM_007051	NP_008982			FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)														---	---	---	---
RNF11	26994	broad.mit.edu	37	1	51716222	51716223	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51716222_51716223delTT	uc001csi.3	+							NM_014372	NP_055187			ring finger protein 11						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	DNA binding|protein binding|zinc ion binding				0																		---	---	---	---
EPS15	2060	broad.mit.edu	37	1	51874110	51874110	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:51874110delT	uc001csq.1	-						EPS15_uc009vyz.1_Intron|EPS15_uc001csp.3_Intron	NM_001981	NP_001972			epidermal growth factor receptor pathway						cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2								T	MLL	ALL								---	---	---	---
NRD1	4898	broad.mit.edu	37	1	52302137	52302138	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52302137_52302138insA	uc001ctc.3	-						NRD1_uc009vzb.2_Intron|NRD1_uc001ctd.3_Intron|NRD1_uc001cte.2_Intron|NRD1_uc001ctf.2_Intron|NRD1_uc010ong.1_Intron|NRD1_uc009vzc.1_Intron|MIR761_hsa-mir-761|MI0003941_5'Flank	NM_002525	NP_002516			nardilysin isoform a						cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
ZYG11B	79699	broad.mit.edu	37	1	53250535	53250535	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53250535delT	uc001cuj.2	+						ZYG11B_uc009vzg.2_Intron|ZYG11B_uc010onj.1_Intron	NM_024646	NP_078922			zyg-11 homolog B								protein binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
LRP8	7804	broad.mit.edu	37	1	53724254	53724255	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53724254_53724255insT	uc001cvi.1	-						LRP8_uc001cvh.1_Intron|LRP8_uc001cvk.1_Intron|LRP8_uc001cvj.1_Intron|LRP8_uc001cvl.1_Intron|LRP8_uc001cvm.1_Intron	NM_004631	NP_004622			low density lipoprotein receptor-related protein						cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0																		---	---	---	---
FAM151A	338094	broad.mit.edu	37	1	55081757	55081757	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55081757delG	uc001cxn.2	-	3	483	c.351delC	c.(349-351)CCCfs	p.P117fs	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	117						integral to membrane					0																		---	---	---	---
USP24	23358	broad.mit.edu	37	1	55573113	55573113	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55573113delA	uc001cyg.3	-							NM_015306	NP_056121			ubiquitin specific protease 24						ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13																		---	---	---	---
USP24	23358	broad.mit.edu	37	1	55604693	55604694	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55604693_55604694delAA	uc001cyg.3	-							NM_015306	NP_056121			ubiquitin specific protease 24						ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	56249917	56249917	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:56249917delA								USP24 (569155 upstream) : PPAP2B (710516 downstream)																																			---	---	---	---
PRKAA2	5563	broad.mit.edu	37	1	57159326	57159326	+	Intron	DEL	A	-	-	rs72195100		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57159326delA	uc001cyk.3	+							NM_006252	NP_006243			AMP-activated protein kinase alpha 2 catalytic						carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6																		---	---	---	---
C8A	731	broad.mit.edu	37	1	57383156	57383156	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:57383156delC	uc001cyo.2	+							NM_000562	NP_000553			complement component 8, alpha polypeptide						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
MYSM1	114803	broad.mit.edu	37	1	59134719	59134720	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59134719_59134720insA	uc009wab.1	-						MYSM1_uc009waa.1_5'Flank|MYSM1_uc001czc.2_Intron	NM_001085487	NP_001078956			Myb-like, SWIRM and MPN domains 1						histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)																	---	---	---	---
JUN	3725	broad.mit.edu	37	1	59247705	59247706	+	3'UTR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59247705_59247706insT	uc001cze.2	-	1						NM_002228	NP_002219			jun oncogene						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding				0	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)			A		sarcoma						OREG0013518	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NFIA	4774	broad.mit.edu	37	1	61798337	61798337	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:61798337delA	uc001czw.2	+						NFIA_uc001czy.2_Intron|NFIA_uc010oos.1_Intron|NFIA_uc001czv.2_Intron	NM_001134673	NP_001128145			nuclear factor I/A isoform 1						DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)|skin(1)	2																		---	---	---	---
TM2D1	83941	broad.mit.edu	37	1	62189461	62189461	+	Intron	DEL	A	-	-	rs147863719		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62189461delA	uc001czz.1	-							NM_032027	NP_114416			beta-amyloid binding protein precursor						apoptosis					ovary(1)	1																		---	---	---	---
DOCK7	85440	broad.mit.edu	37	1	62971308	62971308	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:62971308delA	uc001daq.2	-						DOCK7_uc001dan.2_Intron|DOCK7_uc001dao.2_Intron|DOCK7_uc001dap.2_Intron|DOCK7_uc001dam.2_Intron|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132			dedicator of cytokinesis 7						activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2																		---	---	---	---
JAK1	3716	broad.mit.edu	37	1	65344843	65344844	+	Intron	INS	-	A	A	rs66509261		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65344843_65344844insA	uc001dbu.1	-						JAK1_uc009wam.1_Intron|JAK1_uc001dbv.2_5'Flank	NM_002227	NP_002218			janus kinase 1						interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)				Mis		ALL								---	---	---	---
SGIP1	84251	broad.mit.edu	37	1	67206944	67206944	+	Intron	DEL	T	-	-	rs76751942		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67206944delT	uc001dcr.2	+						SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Intron|SGIP1_uc001dcu.2_Intron	NM_032291	NP_115667			SH3-domain GRB2-like (endophilin) interacting						positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3																		---	---	---	---
WDR78	79819	broad.mit.edu	37	1	67292738	67292738	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:67292738delA	uc001dcx.2	-						WDR78_uc009waw.2_Intron|WDR78_uc009wax.2_Intron	NM_024763	NP_079039			WD repeat domain 78 isoform 1											ovary(2)	2																		---	---	---	---
SFRS11	9295	broad.mit.edu	37	1	70694097	70694097	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:70694097delT	uc001des.2	+						SFRS11_uc009wbi.2_Intron|SFRS11_uc009wbj.1_Intron|SFRS11_uc010oqo.1_Intron|SFRS11_uc001det.2_Intron|SFRS11_uc001deu.2_Intron|SFRS11_uc001dev.2_5'Flank	NM_004768	NP_004759			splicing factor, arginine/serine-rich 11						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0																		---	---	---	---
HHLA3	11147	broad.mit.edu	37	1	70832109	70832109	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:70832109delT	uc001dfa.2	+						HHLA3_uc010oqp.1_Intron|HHLA3_uc001dfb.2_Intron|HHLA3_uc001dfc.2_Intron	NM_001036645	NP_001031722			HERV-H LTR-associating 3 isoform 2								protein binding				0																		---	---	---	---
ZRANB2	9406	broad.mit.edu	37	1	71534883	71534883	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71534883delA	uc001dft.2	-						ZRANB2_uc001dfs.2_Intron|uc010oqr.1_5'Flank|MIR186_hsa-mir-186|MI0000483_5'Flank	NM_203350	NP_976225			zinc finger protein 265 isoform 1						mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2																		---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74928984	74928984	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74928984delA	uc001dgf.1	+						TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron	NM_015978	NP_057062			TNNI3 interacting kinase isoform b							cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
CRYZ	1429	broad.mit.edu	37	1	75175719	75175719	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:75175719delA	uc001dgk.2	-						CRYZ_uc001dgj.2_Intron|CRYZ_uc001dgl.2_Intron|CRYZ_uc001dgm.2_Intron	NM_001130042	NP_001123514			crystallin, zeta isoform a						protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)													---	---	---	---
SLC44A5	204962	broad.mit.edu	37	1	76084756	76084756	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76084756delA	uc010oqz.1	-						SLC44A5_uc010orb.1_Intron	NM_001130058	NP_001123530			solute carrier family 44, member 5 isoform B							integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4																		---	---	---	---
ACADM	34	broad.mit.edu	37	1	76198466	76198466	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76198466delT	uc001dgw.3	+						ACADM_uc010orc.1_Intron|ACADM_uc010ord.1_Intron|ACADM_uc009wbp.2_Intron|ACADM_uc009wbr.2_Intron|ACADM_uc010ore.1_Intron|ACADM_uc010orf.1_Intron|ACADM_uc001dgx.3_Intron|ACADM_uc010org.1_Intron	NM_000016	NP_000007			medium-chain acyl-CoA dehydrogenase isoform a						carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
ACADM	34	broad.mit.edu	37	1	76198678	76198679	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76198678_76198679insT	uc001dgw.3	+						ACADM_uc010orc.1_Intron|ACADM_uc010ord.1_Intron|ACADM_uc009wbp.2_Intron|ACADM_uc009wbr.2_Intron|ACADM_uc010ore.1_Intron|ACADM_uc010orf.1_Intron|ACADM_uc001dgx.3_Intron|ACADM_uc010org.1_Intron	NM_000016	NP_000007			medium-chain acyl-CoA dehydrogenase isoform a						carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
MSH4	4438	broad.mit.edu	37	1	76272600	76272600	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:76272600delT	uc001dhd.1	+							NM_002440	NP_002431			mutS homolog 4						chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5													MMR					---	---	---	---
Unknown	0	broad.mit.edu	37	1	78240627	78240627	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:78240627delT								USP33 (15090 upstream) : FAM73A (4682 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	1	81674934	81674935	+	IGR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:81674934_81674935delAA								None (None upstream) : LPHN2 (96910 downstream)																																			---	---	---	---
WDR63	126820	broad.mit.edu	37	1	85547084	85547084	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:85547084delA	uc001dkt.2	+	4	462	c.271delA	c.(271-273)AAAfs	p.K91fs	WDR63_uc009wcl.2_Frame_Shift_Del_p.K91fs	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	91										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)														---	---	---	---
PKN2	5586	broad.mit.edu	37	1	89294102	89294102	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89294102delT	uc001dmn.2	+						PKN2_uc010osp.1_Intron|PKN2_uc010osq.1_Intron|PKN2_uc009wcv.2_Intron|PKN2_uc010osr.1_Intron	NM_006256	NP_006247			protein kinase N2						signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)														---	---	---	---
GBP7	388646	broad.mit.edu	37	1	89613062	89613062	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:89613062delA	uc001dna.2	-						GBP2_uc001dmy.1_Intron	NM_207398	NP_997281			guanylate binding protein 4-like							integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)														---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91813137	91813137	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91813137delA	uc001doa.3	-						HFM1_uc009wdb.2_Intron|HFM1_uc010osu.1_Intron|HFM1_uc001dob.3_5'Flank|HFM1_uc010osv.1_Intron	NM_001017975	NP_001017975			HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
FNBP1L	54874	broad.mit.edu	37	1	94018104	94018104	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94018104delT	uc001dpw.2	+	14					FNBP1L_uc001dpv.2_3'UTR|FNBP1L_uc010otk.1_3'UTR|FNBP1L_uc010otl.1_3'UTR	NM_001024948	NP_001020119			formin binding protein 1-like isoform 1						endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)														---	---	---	---
ARHGAP29	9411	broad.mit.edu	37	1	94643144	94643144	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:94643144delT	uc001dqj.3	-						ARHGAP29_uc009wdq.1_Intron|ARHGAP29_uc001dqk.2_3'UTR	NM_004815	NP_004806			PTPL1-associated RhoGAP 1						Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)														---	---	---	---
SASS6	163786	broad.mit.edu	37	1	100572825	100572825	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100572825delA	uc001dsu.2	-						SASS6_uc009wdz.2_Intron	NM_194292	NP_919268			spindle assembly abnormal protein 6						centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)														---	---	---	---
CDC14A	8556	broad.mit.edu	37	1	100889837	100889837	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100889837delC	uc001dtg.3	+	5	857	c.369delC	c.(367-369)AACfs	p.N123fs	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Frame_Shift_Del_p.N65fs|CDC14A_uc001dte.3_Frame_Shift_Del_p.N123fs|CDC14A_uc001dtf.2_Frame_Shift_Del_p.N123fs|CDC14A_uc009wed.1_5'UTR|CDC14A_uc009wee.2_Frame_Shift_Del_p.N123fs	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	123	A.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)														---	---	---	---
SLC30A7	148867	broad.mit.edu	37	1	101361673	101361674	+	5'UTR	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:101361673_101361674delTC	uc001dtn.2	+	1					EXTL2_uc001dtk.1_5'Flank|EXTL2_uc001dtl.1_5'Flank|EXTL2_uc010ouk.1_5'Flank|EXTL2_uc001dtm.1_5'Flank|SLC30A7_uc001dto.2_5'UTR	NM_001144884	NP_001138356			zinc transporter like 2						zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)														---	---	---	---
OLFM3	118427	broad.mit.edu	37	1	102312285	102312285	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:102312285delT	uc001duf.2	-						OLFM3_uc001dug.2_Intron|OLFM3_uc001duh.2_Intron|OLFM3_uc001dui.2_Intron|OLFM3_uc001duj.2_Intron|OLFM3_uc001due.2_Intron	NM_058170	NP_477518			olfactomedin 3							extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)														---	---	---	---
SLC25A24	29957	broad.mit.edu	37	1	108728581	108728581	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:108728581delA	uc001dvn.3	-						SLC25A24_uc001dvm.2_Intron	NM_013386	NP_037518			solute carrier family 25 member 24 isoform 1						transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)														---	---	---	---
MYBPHL	343263	broad.mit.edu	37	1	109836686	109836686	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109836686delA	uc001dxk.1	-						MYBPHL_uc010ovh.1_Intron|MYBPHL_uc001dxl.2_Intron	NM_001010985	NP_001010985			myosin binding protein H-like											ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)														---	---	---	---
SYPL2	284612	broad.mit.edu	37	1	110019349	110019350	+	Intron	DEL	GA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110019349_110019350delGA	uc001dxp.2	+						SYPL2_uc001dxo.2_Intron|SYPL2_uc010ovk.1_Intron|SYPL2_uc001dxq.2_5'Flank	NM_001040709	NP_001035799			mitsugumin 29							integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)														---	---	---	---
GNAI3	2773	broad.mit.edu	37	1	110129583	110129583	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110129583delT	uc001dxz.2	+							NM_006496	NP_006487			guanine nucleotide binding protein (G protein),						cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)														---	---	---	---
CEPT1	10390	broad.mit.edu	37	1	111690320	111690320	+	5'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111690320delA	uc001eah.1	+	2					CEPT1_uc001eag.2_5'UTR|CEPT1_uc001eai.1_5'UTR|CEPT1_uc001eaj.1_5'UTR	NM_001007794	NP_001007795			choline/ethanolaminephosphotransferase							endoplasmic reticulum membrane|integral to membrane|nuclear membrane	diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|metal ion binding				0		all_cancers(81;2.27e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0173)|Colorectal(144;0.0375)|all cancers(265;0.0701)|LUSC - Lung squamous cell carcinoma(189;0.0888)|Epithelial(280;0.103)|COAD - Colon adenocarcinoma(174;0.141)	Choline(DB00122)													---	---	---	---
LRIG2	9860	broad.mit.edu	37	1	113635953	113635953	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:113635953delT	uc001edf.1	+						LRIG2_uc009wgn.1_Intron	NM_014813	NP_055628			leucine-rich repeats and immunoglobulin-like							cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)														---	---	---	---
PTPN22	26191	broad.mit.edu	37	1	114377352	114377353	+	Intron	DEL	AA	-	-	rs79608028		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114377352_114377353delAA	uc001eds.2	-						PTPN22_uc009wgq.2_Intron|PTPN22_uc010owo.1_Intron|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Intron|PTPN22_uc009wgs.2_Intron|PTPN22_uc001edu.2_Intron	NM_015967	NP_057051			protein tyrosine phosphatase, non-receptor type						negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
CSDE1	7812	broad.mit.edu	37	1	115279333	115279334	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115279333_115279334delAA	uc001efk.2	-						CSDE1_uc001efi.2_Intron|CSDE1_uc001efj.2_Intron|CSDE1_uc001efl.2_Intron|CSDE1_uc001efm.2_Intron|CSDE1_uc009wgv.2_Intron|CSDE1_uc001efn.2_Intron	NM_001007553	NP_001007554			upstream of NRAS isoform 1						male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
SLC22A15	55356	broad.mit.edu	37	1	116606992	116606992	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116606992delC	uc001egb.3	+							NM_018420	NP_060890			solute carrier family 22, member 15						ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)														---	---	---	---
ATP1A1	476	broad.mit.edu	37	1	116927352	116927353	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116927352_116927353insT	uc001ege.2	+						ATP1A1_uc010owv.1_Intron|ATP1A1_uc001egd.2_Intron|ATP1A1_uc010oww.1_Intron|ATP1A1_uc010owx.1_Intron	NM_000701	NP_000692			Na+/K+ -ATPase alpha 1 subunit isoform a						ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)													---	---	---	---
ATP1A1	476	broad.mit.edu	37	1	116935412	116935412	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116935412delT	uc001ege.2	+						ATP1A1_uc010owv.1_Intron|ATP1A1_uc010oww.1_Intron|ATP1A1_uc010owx.1_Intron	NM_000701	NP_000692			Na+/K+ -ATPase alpha 1 subunit isoform a						ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)													---	---	---	---
CD58	965	broad.mit.edu	37	1	117078855	117078855	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117078855delA	uc001egm.2	-						CD58_uc001egn.2_Intron|CD58_uc010owy.1_Intron|CD58_uc001ego.1_Intron|CD58_uc001egp.3_Intron	NM_001779	NP_001770			CD58 molecule isoform 1						blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding				0	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)														---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117158604	117158604	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117158604delT	uc001egr.1	-						IGSF3_uc001egq.1_Intron	NM_001007237	NP_001007238			immunoglobulin superfamily, member 3 isoform 2							integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
IGSF3	3321	broad.mit.edu	37	1	117209113	117209114	+	5'UTR	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117209113_117209114insG	uc001egr.1	-	2					IGSF3_uc001egq.1_5'UTR	NM_001007237	NP_001007238			immunoglobulin superfamily, member 3 isoform 2							integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)														---	---	---	---
SPAG17	200162	broad.mit.edu	37	1	118514724	118514725	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118514724_118514725delAA	uc001ehk.2	-							NM_206996	NP_996879			sperm associated antigen 17							cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)														---	---	---	---
SPAG17	200162	broad.mit.edu	37	1	118526544	118526545	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:118526544_118526545insA	uc001ehk.2	-							NM_206996	NP_996879			sperm associated antigen 17							cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)														---	---	---	---
WARS2	10352	broad.mit.edu	37	1	119628079	119628080	+	Intron	INS	-	T	T	rs55653025		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:119628079_119628080insT	uc001ehn.2	-						WARS2_uc010oxf.1_Intron|WARS2_uc001ehm.2_Intron|WARS2_uc010oxg.1_Intron|WARS2_uc010oxh.1_Intron|WARS2_uc010oxi.1_Intron	NM_015836	NP_056651			mitochondrial tryptophanyl tRNA synthetase 2						tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)													---	---	---	---
NOTCH2	4853	broad.mit.edu	37	1	120510373	120510373	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120510373delT	uc001eik.2	-						NOTCH2_uc001eil.2_Intron|NOTCH2_uc001eim.3_Intron	NM_024408	NP_077719			notch 2 preproprotein						anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)				N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	1	142827233	142827234	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:142827233_142827234insA	uc001eiw.1	+						uc001ejb.2_Intron|uc001ejd.1_Intron					Homo sapiens PNAS-130 mRNA, complete cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	1	143376682	143376682	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:143376682delC								None (None upstream) : LOC100286793 (270957 downstream)																																			---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145368208	145368213	+	Intron	DEL	TCTCTG	-	-	rs72354261		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145368208_145368213delTCTCTG	uc001end.3	+						NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792			hypothetical protein LOC100132406												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
NBPF10	100132406	broad.mit.edu	37	1	145611594	145611594	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145611594delT	uc001emp.3	+						RNF115_uc001eoj.2_Intron|RNF115_uc001eok.2_Intron|RNF115_uc009wiy.2_Intron|POLR3C_uc001eog.2_5'Flank|POLR3C_uc001eoh.2_5'Flank|POLR3C_uc001eoi.2_5'Flank|POLR3C_uc009wix.2_5'Flank	NM_017940	NP_060410			hypothetical protein LOC55672												0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)														---	---	---	---
Unknown	0	broad.mit.edu	37	1	146526940	146526940	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146526940delA								LOC728989 (12341 upstream) : PRKAB2 (99747 downstream)																																			---	---	---	---
PRKAB2	5565	broad.mit.edu	37	1	146633385	146633385	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146633385delA	uc001epe.2	-						PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Intron	NM_005399	NP_005390			AMP-activated protein kinase beta 2						carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)													---	---	---	---
CHD1L	9557	broad.mit.edu	37	1	146731281	146731281	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:146731281delA	uc001epm.3	+						uc001epp.2_RNA|CHD1L_uc001epn.3_Intron|CHD1L_uc010ozo.1_Intron|CHD1L_uc009wjg.2_Intron|CHD1L_uc009wjh.2_Intron|CHD1L_uc010ozp.1_Intron|CHD1L_uc001epo.3_Intron	NM_004284	NP_004275			chromodomain helicase DNA binding protein						chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)																	---	---	---	---
VPS45	11311	broad.mit.edu	37	1	150054785	150054785	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150054785delT	uc001etp.2	+						VPS45_uc010pbp.1_Intron|VPS45_uc010pbq.1_Intron|VPS45_uc010pbs.1_Intron|VPS45_uc001etq.2_Intron|VPS45_uc009wlm.1_Intron	NM_007259	NP_009190			vacuolar protein sorting 45A						blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
PLEKHO1	51177	broad.mit.edu	37	1	150130885	150130885	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150130885delA	uc001ett.2	+						PLEKHO1_uc001etr.2_Intron|PLEKHO1_uc001ets.2_Intron|PLEKHO1_uc001etu.2_Intron	NM_016274	NP_057358			pleckstrin homology domain containing, family O							cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
PLEKHO1	51177	broad.mit.edu	37	1	150131249	150131249	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150131249delC	uc001ett.2	+	6	1039	c.761delC	c.(760-762)ACCfs	p.T254fs	PLEKHO1_uc001etr.2_Frame_Shift_Del_p.T82fs|PLEKHO1_uc001ets.2_Frame_Shift_Del_p.T71fs|PLEKHO1_uc001etu.2_Frame_Shift_Del_p.T82fs	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	254	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
ARNT	405	broad.mit.edu	37	1	150801843	150801843	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150801843delA	uc001evr.1	-						ARNT_uc001evs.1_Intron|ARNT_uc009wmb.1_Intron|ARNT_uc009wmc.1_Intron|ARNT_uc009wmd.1_Intron|ARNT_uc009wme.1_Intron|ARNT_uc010pcl.1_Intron	NM_001668	NP_001659			aryl hydrocarbon receptor nuclear translocator						positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)					T	ETV6	AML								---	---	---	---
SETDB1	9869	broad.mit.edu	37	1	150917623	150917624	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150917623_150917624insG	uc001evu.2	+						SETDB1_uc009wmf.2_Intron|SETDB1_uc001evv.2_Intron|SETDB1_uc001evw.3_Frame_Shift_Ins_p.G393fs|SETDB1_uc009wmg.1_Intron	NM_001145415	NP_001138887			SET domain, bifurcated 1 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
BNIPL	149428	broad.mit.edu	37	1	151010862	151010862	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151010862delA	uc001ewl.2	+						BNIPL_uc009wmi.2_Intron|BNIPL_uc009wmj.2_5'Flank	NM_138278	NP_612122			BCL2/adenovirus E1B 19kD interacting protein						apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
SCNM1	79005	broad.mit.edu	37	1	151140889	151140889	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151140889delT	uc001ewz.2	+						LYSMD1_uc001ewy.2_5'Flank|LYSMD1_uc010pcr.1_5'Flank|SCNM1_uc009wmn.2_Intron	NM_024041	NP_076946			sodium channel modifier 1						mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	151142409	151142409	+	IGR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151142409delG								SCNM1 (797 upstream) : TMOD4 (55 downstream)																																			---	---	---	---
PIP5K1A	8394	broad.mit.edu	37	1	151219378	151219378	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151219378delT	uc001exj.2	+						PIP5K1A_uc001exi.2_Intron|PIP5K1A_uc010pcu.1_Intron|PIP5K1A_uc001exk.2_Intron|PIP5K1A_uc010pcv.1_Intron	NM_001135638	NP_001129110			phosphatidylinositol-4-phosphate 5-kinase, type						phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			ovary(1)|central_nervous_system(1)|skin(1)	3	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
CGN	57530	broad.mit.edu	37	1	151492628	151492628	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151492628delT	uc009wmw.2	+							NM_020770	NP_065821			cingulin							myosin complex|tight junction	actin binding|motor activity			ovary(2)|pancreas(1)	3	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
THEM4	117145	broad.mit.edu	37	1	151849315	151849315	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151849315delT	uc001ezj.1	-						THEM4_uc001ezk.1_Intron	NM_053055	NP_444283			thioesterase superfamily member 4						insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
S100A6	6277	broad.mit.edu	37	1	153507086	153507086	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153507086delA	uc001fbw.1	-	3						NM_014624	NP_055439			S100 calcium-binding protein A6						axonogenesis|positive regulation of fibroblast proliferation|signal transduction	cytosol|extrinsic to internal side of plasma membrane|nuclear envelope|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding|tropomyosin binding			ovary(1)	1	all_lung(78;1.66e-32)|Lung NSC(65;5.71e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)															---	---	---	---
SLC27A3	11000	broad.mit.edu	37	1	153751860	153751860	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153751860delC	uc001fcz.2	+	9	1992	c.1927delC	c.(1927-1929)CCCfs	p.P643fs	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	643					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
NUP210L	91181	broad.mit.edu	37	1	154091298	154091298	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154091298delA	uc001fdw.2	-						NUP210L_uc009woq.2_Intron|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191			nucleoporin 210kDa-like isoform 1							integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)															---	---	---	---
SHE	126669	broad.mit.edu	37	1	154461449	154461449	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154461449delA	uc001ffb.2	-						SHE_uc001ffc.2_Intron	NM_001010846	NP_001010846			Src homology 2 domain containing E											breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)															---	---	---	---
ADAR	103	broad.mit.edu	37	1	154557172	154557172	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:154557172delA	uc001ffh.2	-	15					ADAR_uc001ffj.2_3'UTR|ADAR_uc001ffi.2_3'UTR|ADAR_uc001ffk.2_3'UTR	NM_001111	NP_001102			adenosine deaminase, RNA-specific isoform a						adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)														---	---	---	---
ASH1L	55870	broad.mit.edu	37	1	155447491	155447491	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155447491delA	uc009wqq.2	-						ASH1L_uc001fkt.2_Intron	NM_018489	NP_060959			absent, small, or homeotic 1-like						cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)															---	---	---	---
MSTO2P	100129405	broad.mit.edu	37	1	155716776	155716776	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155716776delA	uc010pgn.1	+						MSTO2P_uc010pgo.1_Intron|MSTO2P_uc010pgp.1_Intron	NM_018116	NP_060586			misato												0																		---	---	---	---
KIAA0907	22889	broad.mit.edu	37	1	155886695	155886695	+	Intron	DEL	T	-	-	rs113079820		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155886695delT	uc001fmi.1	-						KIAA0907_uc001fmj.1_Intron|KIAA0907_uc009wrk.1_Intron|KIAA0907_uc009wrl.1_Intron	NM_014949	NP_055764			hypothetical protein LOC22889												0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)															---	---	---	---
TMEM79	84283	broad.mit.edu	37	1	156255497	156255498	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156255497_156255498insC	uc010phi.1	+	2	676_677	c.480_481insC	c.(478-483)ATGCCCfs	p.M160fs	SMG5_uc001foc.3_5'Flank|TMEM79_uc001fod.2_Frame_Shift_Ins_p.M1fs|TMEM79_uc009wrw.2_Frame_Shift_Ins_p.M160fs	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	160_161						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)																	---	---	---	---
ISG20L2	81875	broad.mit.edu	37	1	156694023	156694023	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156694023delG	uc001fps.1	-	2	1126	c.865delC	c.(865-867)CTCfs	p.L289fs	ISG20L2_uc001fpt.1_Frame_Shift_Del_p.L289fs	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	interferon stimulated exonuclease gene	289	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)																	---	---	---	---
KCNJ10	3766	broad.mit.edu	37	1	160012018	160012018	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160012018delG	uc001fuw.1	-	2	455	c.305delC	c.(304-306)CCGfs	p.P102fs		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	102	Extracellular (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)															---	---	---	---
ATP1A2	477	broad.mit.edu	37	1	160104819	160104819	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160104819delG	uc001fvc.2	+						ATP1A2_uc001fvb.2_Intron|ATP1A2_uc001fvd.2_Intron	NM_000702	NP_000693			Na+/K+ -ATPase alpha 2 subunit proprotein						ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)															---	---	---	---
RGS5	8490	broad.mit.edu	37	1	163137887	163137887	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163137887delA	uc001gcn.2	-						RGS5_uc009wvb.2_Intron	NM_003617	NP_003608			regulator of G-protein signalling 5						negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)															---	---	---	---
RGS5	8490	broad.mit.edu	37	1	163137955	163137956	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163137955_163137956insG	uc001gcn.2	-						RGS5_uc009wvb.2_Intron	NM_003617	NP_003608			regulator of G-protein signalling 5						negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)															---	---	---	---
NUF2	83540	broad.mit.edu	37	1	163297383	163297383	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163297383delT	uc001gcq.1	+						NUF2_uc001gcp.2_Intron|NUF2_uc001gcr.1_Intron|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735			NUF2, NDC80 kinetochore complex component						cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)																	---	---	---	---
NUF2	83540	broad.mit.edu	37	1	163313695	163313696	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:163313695_163313696insA	uc001gcq.1	+						NUF2_uc001gcp.2_Intron|NUF2_uc001gcr.1_Intron|NUF2_uc009wvc.1_Intron	NM_145697	NP_663735			NUF2, NDC80 kinetochore complex component						cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)																	---	---	---	---
PBX1	5087	broad.mit.edu	37	1	164789505	164789506	+	Intron	DEL	AG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:164789505_164789506delAG	uc001gct.2	+						PBX1_uc010pku.1_Intron|PBX1_uc010pkv.1_Intron|PBX1_uc001gcs.2_Intron|PBX1_uc010pkw.1_Intron	NM_002585	NP_002576			pre-B-cell leukemia homeobox 1						negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5								T	TCF3|EWSR1	pre B-ALL|myoepithelioma								---	---	---	---
MGST3	4259	broad.mit.edu	37	1	165618961	165618961	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:165618961delT	uc001gdf.2	+						MGST3_uc001gdg.2_Intron	NM_004528	NP_004519			microsomal glutathione S-transferase 3						leukotriene biosynthetic process|leukotriene production involved in inflammatory response|signal transduction|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glutathione peroxidase activity|glutathione transferase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Glutathione(DB00143)													---	---	---	---
XCL2	6846	broad.mit.edu	37	1	168511355	168511355	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:168511355delA	uc001gfn.3	-							NM_003175	NP_003166			chemokine (C motif) ligand 2 precursor						blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)																	---	---	---	---
NME7	29922	broad.mit.edu	37	1	169138311	169138311	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169138311delA	uc001gfu.2	-						NME7_uc010plq.1_Intron|NME7_uc001gft.2_Intron	NM_013330	NP_037462			nucleoside diphosphate kinase 7 isoform a						CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)																	---	---	---	---
C1orf114	57821	broad.mit.edu	37	1	169366580	169366580	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169366580delT	uc001gga.1	-	5	1433	c.1265delA	c.(1264-1266)AAGfs	p.K422fs	C1orf114_uc001gfz.1_Frame_Shift_Del_p.K421fs|C1orf114_uc009wvq.1_Frame_Shift_Del_p.K421fs	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	422											0	all_hematologic(923;0.208)																	---	---	---	---
C1orf112	55732	broad.mit.edu	37	1	169776833	169776834	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169776833_169776834insT	uc001ggp.2	+						C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggq.2_Intron|C1orf112_uc009wvt.2_Intron|C1orf112_uc010plu.1_Intron|C1orf112_uc009wvu.1_Intron|C1orf112_uc001ggr.2_Intron|C1orf112_uc010plv.1_Intron	NM_018186	NP_060656			hypothetical protein LOC55732												0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
PRRX1	5396	broad.mit.edu	37	1	170705416	170705416	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:170705416delA	uc001ghf.2	+	4					PRRX1_uc001ghe.2_3'UTR	NM_022716	NP_073207			paired mesoderm homeobox 1 isoform pmx-1b							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
C1orf129	80133	broad.mit.edu	37	1	170916840	170916840	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:170916840delA	uc001ghg.2	+						C1orf129_uc009wvy.2_Intron|C1orf129_uc010plz.1_Intron	NM_025063	NP_079339			hypothetical protein LOC80133 isoform 2								binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
BAT2L2	23215	broad.mit.edu	37	1	171505457	171505457	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:171505457delT	uc010pmg.1	+							NM_015172	NP_055987			HBxAg transactivated protein 2								protein C-terminus binding				0																		---	---	---	---
FASLG	356	broad.mit.edu	37	1	172633384	172633384	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:172633384delT	uc001gis.2	+						FASLG_uc001git.2_Intron	NM_000639	NP_000630			fas ligand						activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			lung(2)|breast(1)	3																		---	---	---	---
SLC9A11	284525	broad.mit.edu	37	1	173545908	173545908	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173545908delA	uc001giz.2	-						SLC9A11_uc009wwe.2_5'Flank|SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622			solute carrier family 9, member 11						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2																		---	---	---	---
KLHL20	27252	broad.mit.edu	37	1	173735435	173735435	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173735435delT	uc001gjc.2	+						KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_Intron	NM_014458	NP_055273			kelch-like 20						cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
RC3H1	149041	broad.mit.edu	37	1	173930702	173930702	+	Intron	DEL	A	-	-	rs71715802		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:173930702delA	uc001gju.3	-						RC3H1_uc010pms.1_Intron|RC3H1_uc001gjv.2_Intron|RC3H1_uc010pmt.1_Intron	NM_172071	NP_742068			roquin						cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174241536	174241536	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174241536delC	uc001gjx.2	+						RABGAP1L_uc009wwq.1_Intron|RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_5'Flank	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
RABGAP1L	9910	broad.mit.edu	37	1	174721308	174721308	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:174721308delA	uc001gjx.2	+						RABGAP1L_uc001gkb.3_Intron|RABGAP1L_uc001gkc.3_Intron|RABGAP1L_uc001gkd.3_Intron	NM_014857	NP_055672			RAB GTPase activating protein 1-like isoform A						regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4																		---	---	---	---
RFWD2	64326	broad.mit.edu	37	1	175958359	175958359	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:175958359delA	uc001gku.1	-						RFWD2_uc001gkv.1_Intron|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_Intron|RFWD2_uc001gkt.1_Intron	NM_022457	NP_071902			ring finger and WD repeat domain 2 isoform a						DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
PAPPA2	60676	broad.mit.edu	37	1	176679061	176679061	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:176679061delT	uc001gkz.2	+						PAPPA2_uc009www.2_Intron	NM_020318	NP_064714			pappalysin 2 isoform 1						cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16																		---	---	---	---
FAM5B	57795	broad.mit.edu	37	1	177242774	177242774	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:177242774delA	uc001glf.2	+						FAM5B_uc010pna.1_Intron|FAM5B_uc001glg.2_Intron	NM_021165	NP_066988			family with sequence similarity 5, member B							extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6																		---	---	---	---
NPHS2	7827	broad.mit.edu	37	1	179530415	179530415	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:179530415delT	uc001gmq.3	-						NPHS2_uc009wxi.2_Intron	NM_014625	NP_055440			podocin						excretion	integral to plasma membrane	protein binding				0																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181708297	181708298	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181708297_181708298insT	uc001gow.2	+	25	3792_3793	c.3627_3628insT	c.(3625-3630)GGCTTGfs	p.G1209fs	CACNA1E_uc009wxs.2_Frame_Shift_Ins_p.G1097fs|CACNA1E_uc001gox.1_Frame_Shift_Ins_p.G435fs|CACNA1E_uc009wxt.2_Frame_Shift_Ins_p.G435fs	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1209_1210	III.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
CACNA1E	777	broad.mit.edu	37	1	181755020	181755021	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:181755020_181755021insC	uc001gow.2	+						CACNA1E_uc009wxs.2_Intron|CACNA1E_uc009wxt.2_Intron	NM_000721	NP_000712			calcium channel, voltage-dependent, R type,						energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6																		---	---	---	---
DHX9	1660	broad.mit.edu	37	1	182850220	182850220	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:182850220delT	uc001gpr.2	+						DHX9_uc001gps.2_Intron|DHX9_uc001gpt.2_Intron|DHX9_uc009wyd.2_5'Flank	NM_001357	NP_001348			DEAH (Asp-Glu-Ala-His) box polypeptide 9						CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2																		---	---	---	---
LAMC1	3915	broad.mit.edu	37	1	183085864	183085865	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183085864_183085865delAA	uc001gpy.3	+							NM_002293	NP_002284			laminin, gamma 1 precursor						axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
RGL1	23179	broad.mit.edu	37	1	183852826	183852828	+	Intron	DEL	TCT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:183852826_183852828delTCT	uc001gqo.2	+						RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron|RGL1_uc010poi.1_Intron	NM_015149	NP_055964			ral guanine nucleotide dissociation						cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	185891397	185891397	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:185891397delT	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186040037	186040037	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186040037delA	uc001grq.1	+							NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
HMCN1	83872	broad.mit.edu	37	1	186120313	186120313	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186120313delT	uc001grq.1	+						HMCN1_uc001grs.1_Intron	NM_031935	NP_114141			hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23																		---	---	---	---
PRG4	10216	broad.mit.edu	37	1	186280259	186280259	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186280259delT	uc001gru.3	+	9	3644	c.3593delT	c.(3592-3594)GTTfs	p.V1198fs	PRG4_uc001grt.3_Frame_Shift_Del_p.V1157fs|PRG4_uc009wyl.2_Frame_Shift_Del_p.V1105fs|PRG4_uc009wym.2_Frame_Shift_Del_p.V1064fs|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1198	Hemopexin-like 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1																		---	---	---	---
TPR	7175	broad.mit.edu	37	1	186287469	186287470	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186287469_186287470insC	uc001grv.2	-							NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
TPR	7175	broad.mit.edu	37	1	186303749	186303749	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186303749delT	uc001grv.2	-							NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
TPR	7175	broad.mit.edu	37	1	186307132	186307132	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186307132delT	uc001grv.2	-							NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
TPR	7175	broad.mit.edu	37	1	186328859	186328859	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:186328859delA	uc001grv.2	-						TPR_uc010pop.1_Intron	NM_003292	NP_003283			nuclear pore complex-associated protein TPR						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)				T	NTRK1	papillary thyroid								---	---	---	---
RGS18	64407	broad.mit.edu	37	1	192128012	192128012	+	Intron	DEL	A	-	-	rs28417375		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192128012delA	uc001gsg.2	+							NM_130782	NP_570138			regulator of G-protein signalling 18						negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3																		---	---	---	---
RGS13	6003	broad.mit.edu	37	1	192627277	192627277	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192627277delT	uc001gsj.2	+						RGS13_uc001gsk.2_Intron	NM_002927	NP_002918			regulator of G-protein signalling 13							plasma membrane	GTPase activator activity|signal transducer activity				0																		---	---	---	---
UCHL5	51377	broad.mit.edu	37	1	192997104	192997104	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:192997104delA	uc001gsm.2	-						UCHL5_uc001gsn.2_Intron|UCHL5_uc001gso.2_Intron|UCHL5_uc010pov.1_Intron|UCHL5_uc001gsp.2_Intron|UCHL5_uc001gsq.2_Intron|UCHL5_uc010pow.1_Intron|UCHL5_uc010pox.1_Intron	NM_015984	NP_057068			ubiquitin carboxyl-terminal hydrolase L5						DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|ovary(1)	3																		---	---	---	---
DENND1B	163486	broad.mit.edu	37	1	197480840	197480840	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:197480840delA	uc010ppe.1	-						DENND1B_uc010ppf.1_Intron	NM_001142795	NP_001136267			DENN/MADD domain containing 1B isoform 1							clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
NEK7	140609	broad.mit.edu	37	1	198222297	198222298	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:198222297_198222298insA	uc001gun.3	+	3	512_513	c.185_186insA	c.(184-186)TTAfs	p.L62fs		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	62	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4																		---	---	---	---
KIF14	9928	broad.mit.edu	37	1	200561380	200561380	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200561380delA	uc010ppk.1	-						KIF14_uc010ppj.1_Intron	NM_014875	NP_055690			kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7																		---	---	---	---
DDX59	83479	broad.mit.edu	37	1	200613353	200613353	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200613353delA	uc009wzk.2	-	8					DDX59_uc010ppl.1_Intron	NM_001031725	NP_001026895			DEAD (Asp-Glu-Ala-Asp) box polypeptide 59							intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
DDX59	83479	broad.mit.edu	37	1	200617702	200617702	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200617702delA	uc009wzk.2	-						DDX59_uc010ppl.1_Intron	NM_001031725	NP_001026895			DEAD (Asp-Glu-Ala-Asp) box polypeptide 59							intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
CAMSAP1L1	23271	broad.mit.edu	37	1	200817150	200817150	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200817150delT	uc001gvl.2	+						CAMSAP1L1_uc001gvk.2_Intron|CAMSAP1L1_uc001gvm.2_Intron	NM_203459	NP_982284			calmodulin regulated spectrin-associated protein							cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	1	200833330	200833330	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:200833330delA								CAMSAP1L1 (3501 upstream) : GPR25 (8836 downstream)																																			---	---	---	---
CNTN2	6900	broad.mit.edu	37	1	205033255	205033255	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205033255delG	uc001hbr.2	+						CNTN2_uc001hbq.1_Intron|CNTN2_uc001hbs.2_Intron	NM_005076	NP_005067			contactin 2 precursor						axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)															---	---	---	---
CTSE	1510	broad.mit.edu	37	1	206331336	206331337	+	3'UTR	DEL	AC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:206331336_206331337delAC	uc001hdu.2	+	9					CTSE_uc001hdv.2_3'UTR|CTSE_uc010prs.1_3'UTR	NM_001910	NP_001901			cathepsin E isoform a preproprotein						antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)															---	---	---	---
CD55	1604	broad.mit.edu	37	1	207512720	207512720	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207512720delT	uc001hfq.3	+						CD55_uc001hfp.3_Intron|CD55_uc001hfr.3_Intron|CD55_uc010psf.1_Intron|CD55_uc009xcf.2_Intron|CD55_uc009xce.2_Intron|CD55_uc009xcg.2_Intron	NM_000574	NP_000565			decay accelerating factor for complement isoform						complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			ovary(1)	1					Chloramphenicol(DB00446)													---	---	---	---
CR2	1380	broad.mit.edu	37	1	207646545	207646545	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207646545delA	uc001hfw.2	+						CR2_uc001hfv.2_Intron|CR2_uc009xch.2_Intron	NM_001877	NP_001868			complement component (3d/Epstein Barr virus)						complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8																		---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207851488	207851488	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207851488delA	uc001hga.3	+						CR1L_uc001hfz.2_Intron|CR1L_uc001hgb.1_Intron	NM_175710	NP_783641			complement component (3b/4b) receptor 1-like							cytoplasm|extracellular region|membrane					0																		---	---	---	---
RPS6KC1	26750	broad.mit.edu	37	1	213434712	213434712	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:213434712delA	uc010ptr.1	+						RPS6KC1_uc001hkd.2_Intron|RPS6KC1_uc010pts.1_Intron|RPS6KC1_uc010ptt.1_Intron|RPS6KC1_uc010ptu.1_Intron|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Intron	NM_012424	NP_036556			ribosomal protein S6 kinase, 52kDa, polypeptide						cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)														---	---	---	---
PTPN14	5784	broad.mit.edu	37	1	214556554	214556554	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214556554delA	uc001hkk.1	-						PTPN14_uc010pty.1_Intron	NM_005401	NP_005392			protein tyrosine phosphatase, non-receptor type						lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)														---	---	---	---
CENPF	1063	broad.mit.edu	37	1	214826106	214826106	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214826106delT	uc001hkm.2	+							NM_016343	NP_057427			centromere protein F						cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)														---	---	---	---
KCTD3	51133	broad.mit.edu	37	1	215749407	215749407	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:215749407delT	uc001hks.2	+						KCTD3_uc001hkt.2_Intron|KCTD3_uc010pub.1_Intron|KCTD3_uc009xdn.2_5'Flank	NM_016121	NP_057205			potassium channel tetramerisation domain							voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)														---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216256672	216256672	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216256672delA	uc001hku.1	-							NM_206933	NP_996816			usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
USH2A	7399	broad.mit.edu	37	1	216497079	216497080	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216497079_216497080insT	uc001hku.1	-						USH2A_uc001hkv.2_Intron	NM_206933	NP_996816			usherin isoform B						maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)											HNSCC(13;0.011)			---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217787674	217787674	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217787674delT	uc001hlf.1	-						GPATCH2_uc001hlg.3_Intron	NM_018040	NP_060510			G patch domain containing 2							intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
RAB3GAP2	25782	broad.mit.edu	37	1	220324483	220324483	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220324483delA	uc010puk.1	-	35					RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_3'UTR|RAB3GAP2_uc001hmh.2_3'UTR	NM_012414	NP_036546			rab3 GTPase-activating protein, non-catalytic						intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)														---	---	---	---
MIR320B-2	100302180	broad.mit.edu	37	1	224444738	224444738	+	RNA	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:224444738delT	hsa-mir-320b-2|MI0003839	-			c.106delT			NVL_uc001hok.2_Intron|NVL_uc001hol.2_Intron|NVL_uc010pvd.1_Intron|NVL_uc010pve.1_Intron|NVL_uc010pvf.1_Intron																	0																		---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228497068	228497068	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228497068delG	uc009xez.1	+						OBSCN_uc001hsn.2_Intron	NM_001098623	NP_001092093			obscurin, cytoskeletal calmodulin and						apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
RAB4A	5867	broad.mit.edu	37	1	229431466	229431467	+	Intron	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229431466_229431467delTC	uc001hth.2	+						RAB4A_uc001hti.2_Intron|RAB4A_uc001htj.2_Intron	NM_004578	NP_004569			RAB4A, member RAS oncogene family								GDP binding|GTP binding|GTPase activity			ovary(1)	1	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)																---	---	---	---
COG2	22796	broad.mit.edu	37	1	230796633	230796633	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230796633delA	uc001htw.2	+						COG2_uc001htx.2_Intron|COG2_uc010pwc.1_Intron	NM_007357	NP_031383			component of oligomeric golgi complex 2 isoform						Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity				0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)																---	---	---	---
TTC13	79573	broad.mit.edu	37	1	231042815	231042815	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231042815delA	uc001huf.3	-						TTC13_uc009xfi.2_Intron|TTC13_uc009xfj.2_Intron|TTC13_uc001hug.3_Intron	NM_024525	NP_078801			tetratricopeptide repeat domain 13 isoform a								binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)														---	---	---	---
TTC13	79573	broad.mit.edu	37	1	231075265	231075265	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231075265delA	uc001huf.3	-						TTC13_uc009xfi.2_Intron|TTC13_uc009xfj.2_Intron|TTC13_uc001hug.3_Intron|TTC13_uc009xfk.1_Intron	NM_024525	NP_078801			tetratricopeptide repeat domain 13 isoform a								binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)														---	---	---	---
C1orf124	83932	broad.mit.edu	37	1	231488893	231488894	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:231488893_231488894insT	uc001hur.2	+	5	1704_1705	c.1256_1257insT	c.(1255-1257)AATfs	p.N419fs	C1orf124_uc001hus.2_3'UTR|C1orf124_uc001hut.2_3'UTR	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	419					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)																---	---	---	---
DISC1	27185	broad.mit.edu	37	1	232002167	232002168	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:232002167_232002168insA	uc001huz.2	+						TSNAX-DISC1_uc010pwl.1_Intron|DISC1_uc010pwy.1_Intron|DISC1_uc010pwz.1_Intron|DISC1_uc010pxa.1_Intron|DISC1_uc001huy.2_Intron|DISC1_uc010pxb.1_Intron|DISC1_uc010pxc.1_Intron|DISC1_uc010pxd.1_Intron|DISC1_uc010pxe.1_Intron|DISC1_uc009xfr.2_Intron|DISC1_uc010pxf.1_Intron|DISC1_uc010pxg.1_Intron|DISC1_uc010pxh.1_Intron|DISC1_uc010pxi.1_Intron|DISC1_uc010pxj.1_Intron|DISC1_uc010pxk.1_Intron|DISC1_uc010pxl.1_Intron|DISC1_uc010pxm.1_Intron|DISC1_uc010pxn.1_Intron|DISC1_uc001hva.2_Intron	NM_018662	NP_061132			disrupted in schizophrenia 1 isoform L						microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)																---	---	---	---
LYST	1130	broad.mit.edu	37	1	235993743	235993743	+	Intron	DEL	A	-	-	rs72106995		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:235993743delA	uc001hxj.2	-						LYST_uc009xgb.1_Intron|LYST_uc010pxs.1_Intron|LYST_uc001hxl.1_Intron|LYST_uc001hxm.2_Intron|LYST_uc001hxn.1_Intron	NM_000081	NP_000072			lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)											Chediak-Higashi_syndrome				---	---	---	---
ERO1LB	56605	broad.mit.edu	37	1	236393400	236393400	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236393400delT	uc001hxt.2	-							NM_019891	NP_063944			endoplasmic reticulum oxidoreductin 1-Lbeta						electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)															---	---	---	---
ERO1LB	56605	broad.mit.edu	37	1	236399233	236399234	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236399233_236399234delTT	uc001hxt.2	-							NM_019891	NP_063944			endoplasmic reticulum oxidoreductin 1-Lbeta						electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding				0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)															---	---	---	---
HEATR1	55127	broad.mit.edu	37	1	236754110	236754110	+	Intron	DEL	A	-	-	rs78564511	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236754110delA	uc001hyd.1	-							NM_018072	NP_060542			protein BAP28						rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)															---	---	---	---
ACTN2	88	broad.mit.edu	37	1	236898890	236898891	+	Intron	DEL	GT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:236898890_236898891delGT	uc001hyf.2	+						ACTN2_uc001hyg.2_Intron|ACTN2_uc009xgi.1_Intron|ACTN2_uc010pxu.1_Intron	NM_001103	NP_001094			actinin, alpha 2						focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)															---	---	---	---
CHRM3	1131	broad.mit.edu	37	1	240072443	240072444	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:240072443_240072444insA	uc001hyp.2	+	5	2471_2472	c.1692_1693insA	c.(1690-1695)GACAAAfs	p.D564fs		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	564_565	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)													---	---	---	---
RGS7	6000	broad.mit.edu	37	1	241518936	241518936	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:241518936delG	uc001hyv.2	-						RGS7_uc001hyu.2_Intron|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Intron	NM_002924	NP_002915			regulator of G-protein signaling 7						G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)															---	---	---	---
FH	2271	broad.mit.edu	37	1	241675449	241675450	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:241675449_241675450insA	uc001hyx.2	-							NM_000143	NP_000134			fumarate hydratase precursor						fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)				Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242024068	242024068	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242024068delT	uc001hzh.2	+						EXO1_uc001hzi.2_Intron|EXO1_uc001hzj.2_Intron|EXO1_uc009xgq.2_Intron	NM_130398	NP_569082			exonuclease 1 isoform b						meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
Unknown	0	broad.mit.edu	37	1	242156490	242156490	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242156490delA								EXO1 (103443 upstream) : MAP1LC3C (2302 downstream)																																			---	---	---	---
CEP170	9859	broad.mit.edu	37	1	243327510	243327510	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:243327510delT	uc001hzs.2	-						CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron|CEP170_uc001hzv.1_Intron	NM_014812	NP_055627			centrosomal protein 170kDa isoform alpha							centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)															---	---	---	---
C1orf101	257044	broad.mit.edu	37	1	244640671	244640671	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244640671delG	uc001iam.2	+						C1orf101_uc001iak.1_Intron|C1orf101_uc001ial.2_Intron|C1orf101_uc010pym.1_Intron|C1orf101_uc010pyn.1_Intron	NM_001130957	NP_001124429			hypothetical protein LOC257044 isoform 1							integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)															---	---	---	---
PPPDE1	51029	broad.mit.edu	37	1	244855423	244855423	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244855423delT	uc001iao.2	+						PPPDE1_uc001iap.2_Intron	NM_016076	NP_057160			PPPDE peptidase domain containing 1											breast(3)	3																		---	---	---	---
PPPDE1	51029	broad.mit.edu	37	1	244857682	244857682	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:244857682delT	uc001iao.2	+						PPPDE1_uc001iap.2_Intron	NM_016076	NP_057160			PPPDE peptidase domain containing 1											breast(3)	3																		---	---	---	---
TFB2M	64216	broad.mit.edu	37	1	246711788	246711789	+	Intron	DEL	AT	-	-	rs12087297	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:246711788_246711789delAT	uc001ibn.2	-							NM_022366	NP_071761			transcription factor B2, mitochondrial						positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)															---	---	---	---
Unknown	0	broad.mit.edu	37	1	247769926	247769927	+	IGR	DEL	CA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247769926_247769927delCA								OR2G3 (110 upstream) : OR13G1 (65493 downstream)																																			---	---	---	---
SNTG2	54221	broad.mit.edu	37	2	1079174	1079174	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1079174delT	uc002qwq.2	+						SNTG2_uc002qwp.2_Intron|SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841			syntrophin, gamma 2						central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)														---	---	---	---
MYT1L	23040	broad.mit.edu	37	2	1890247	1890247	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1890247delT	uc002qxe.2	-						MYT1L_uc002qxd.2_Intron|MYT1L_uc010ewl.1_Intron	NM_015025	NP_055840			myelin transcription factor 1-like						cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)														---	---	---	---
RPS7	6201	broad.mit.edu	37	2	3624458	3624458	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:3624458delA	uc002qxw.2	+						RPS7_uc002qxy.2_5'Flank	NM_001011	NP_001002			ribosomal protein S7						endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)														---	---	---	---
TAF1B	9014	broad.mit.edu	37	2	9991556	9991556	+	Intron	DEL	G	-	-	rs111708404		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:9991556delG	uc002qzz.2	+						TAF1B_uc010exc.2_Intron|TAF1B_uc002qzy.3_Intron|TAF1B_uc010yja.1_Intron|TAF1B_uc010exd.2_Intron	NM_005680	NP_005671			TBP-associated factor 1B						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15330612	15330613	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15330612_15330613insT	uc002rcc.1	-						NBAS_uc002rcb.1_Intron|NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_Intron	NM_015909	NP_056993			neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15537482	15537483	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15537482_15537483insT	uc002rcc.1	-						NBAS_uc010exl.1_Intron|NBAS_uc002rcd.1_Intron	NM_015909	NP_056993			neuroblastoma-amplified protein											ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
DDX1	1653	broad.mit.edu	37	2	15742588	15742588	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15742588delT	uc002rce.2	+						DDX1_uc010yjq.1_Intron	NM_004939	NP_004930			DEAD (Asp-Glu-Ala-Asp) box polypeptide 1						DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)														---	---	---	---
DDX1	1653	broad.mit.edu	37	2	15742787	15742787	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15742787delT	uc002rce.2	+						DDX1_uc010yjq.1_Intron	NM_004939	NP_004930			DEAD (Asp-Glu-Ala-Asp) box polypeptide 1						DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)														---	---	---	---
OSR1	130497	broad.mit.edu	37	2	19553155	19553155	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:19553155delC	uc002rdc.2	-	2	715	c.412delG	c.(412-414)GAGfs	p.E138fs		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	138					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)																---	---	---	---
PUM2	23369	broad.mit.edu	37	2	20526999	20527000	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:20526999_20527000delAA	uc002rds.1	-						PUM2_uc002rdt.1_Intron|PUM2_uc002rdr.2_Intron|PUM2_uc010yjy.1_Intron|PUM2_uc002rdu.1_Intron|PUM2_uc010yjz.1_Intron	NM_015317	NP_056132			pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24509095	24509096	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24509095_24509096insA	uc002rfe.2	-	16	2106_2107	c.1848_1849insT	c.(1846-1851)TTTAACfs	p.F616fs	ITSN2_uc002rff.2_Frame_Shift_Ins_p.F616fs|ITSN2_uc002rfg.2_Frame_Shift_Ins_p.F616fs|ITSN2_uc010eyd.2_Frame_Shift_Ins_p.F641fs	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	616_617	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
ITSN2	50618	broad.mit.edu	37	2	24536277	24536278	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:24536277_24536278insA	uc002rfe.2	-						ITSN2_uc002rff.2_Intron|ITSN2_uc002rfg.2_Intron|ITSN2_uc010eyd.2_Intron	NM_006277	NP_006268			intersectin 2 isoform 1						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
Unknown	0	broad.mit.edu	37	2	26372633	26372633	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:26372633delT								RAB10 (12311 upstream) : HADHA (40872 downstream)																																			---	---	---	---
GPN1	11321	broad.mit.edu	37	2	27855661	27855661	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27855661delA	uc010ymc.1	+						ZNF512_uc010yly.1_Intron|GPN1_uc010ezf.2_Intron|GPN1_uc010yma.1_Intron|GPN1_uc010ymb.1_Intron|GPN1_uc010ymd.1_Intron|GPN1_uc010yme.1_Intron|GPN1_uc010ezg.1_Intron	NM_007266	NP_009197			GPN-loop GTPase 1 isoform a							cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
GPN1	11321	broad.mit.edu	37	2	27864265	27864265	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27864265delT	uc010ymc.1	+						GPN1_uc010ezf.2_Intron|GPN1_uc010yma.1_Intron|GPN1_uc010ymb.1_Intron|GPN1_uc010ymd.1_Intron|GPN1_uc010yme.1_Intron|GPN1_uc010ezg.1_Intron	NM_007266	NP_009197			GPN-loop GTPase 1 isoform a							cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
BRE	9577	broad.mit.edu	37	2	28464370	28464372	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28464370_28464372delTTT	uc002rlr.2	+						BRE_uc002rlp.1_Intron|BRE_uc002rlq.2_Intron|BRE_uc002rls.2_Intron|BRE_uc002rlt.2_Intron|BRE_uc002rlu.2_Intron|BRE_uc002rlv.2_Intron	NM_199194	NP_954664			brain and reproductive organ-expressed (TNFRSF1A						apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
WDR43	23160	broad.mit.edu	37	2	29149283	29149283	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29149283delT	uc002rmo.2	+						SNORD53_uc002rmq.1_5'Flank	NM_015131	NP_055946			WD repeat domain 43							nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
WDR43	23160	broad.mit.edu	37	2	29158614	29158624	+	Intron	DEL	AAAAAAAAAAA	-	-	rs71403630		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:29158614_29158624delAAAAAAAAAAA	uc002rmo.2	+							NM_015131	NP_055946			WD repeat domain 43							nucleolus				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
SPAST	6683	broad.mit.edu	37	2	32341333	32341334	+	Intron	INS	-	TAG	TAG			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32341333_32341334insTAG	uc002roc.2	+						SPAST_uc002rod.2_Intron	NM_014946	NP_055761			spastin isoform 1						cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)																	---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32820253	32820253	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32820253delT	uc010ezu.2	+							NM_016252	NP_057336			baculoviral IAP repeat-containing 6						anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
LTBP1	4052	broad.mit.edu	37	2	33414004	33414004	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33414004delT	uc002ros.2	+						LTBP1_uc002rot.2_Intron|LTBP1_uc002rou.2_Intron|LTBP1_uc002rov.2_Intron|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron	NM_206943	NP_996826			latent transforming growth factor beta binding						negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)																---	---	---	---
RASGRP3	25780	broad.mit.edu	37	2	33744996	33744996	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:33744996delT	uc002rox.2	+						RASGRP3_uc010ync.1_Intron|RASGRP3_uc002roy.2_Intron	NM_170672	NP_733772			RAS guanyl releasing protein 3 (calcium and						MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)																	---	---	---	---
HEATR5B	54497	broad.mit.edu	37	2	37277042	37277042	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:37277042delT	uc002rpp.1	-							NM_019024	NP_061897			HEAT repeat containing 5B								binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)																---	---	---	---
ATL2	64225	broad.mit.edu	37	2	38545836	38545836	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38545836delA	uc002rqq.2	-						ATL2_uc010ynm.1_Intron|ATL2_uc010ynn.1_Intron|ATL2_uc010yno.1_Intron|ATL2_uc002rqs.2_Intron|ATL2_uc002rqr.2_Intron	NM_001135673	NP_001129145			atlastin GTPase 2 isoform 2						endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
ATL2	64225	broad.mit.edu	37	2	38570344	38570344	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38570344delT	uc002rqq.2	-						ATL2_uc010ynm.1_Intron|ATL2_uc010ynn.1_Intron|ATL2_uc010yno.1_Intron|ATL2_uc002rqs.2_Intron|ATL2_uc002rqr.2_Intron	NM_001135673	NP_001129145			atlastin GTPase 2 isoform 2						endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
SOS1	6654	broad.mit.edu	37	2	39262473	39262473	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:39262473delT	uc002rrk.3	-						SOS1_uc010ynr.1_Intron|SOS1_uc002rrj.3_5'Flank|SOS1_uc002rrl.2_Intron	NM_005633	NP_005624			son of sevenless homolog 1						apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)												Noonan_syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	2	41384162	41384162	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:41384162delA								SLC8A1 (644587 upstream) : PKDCC (890999 downstream)																																			---	---	---	---
COX7A2L	9167	broad.mit.edu	37	2	42578275	42578275	+	3'UTR	DEL	A	-	-	rs71682791		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:42578275delA	uc002rsk.2	-	3					COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709			cytochrome c oxidase subunit VIIa polypeptide 2						respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0																		---	---	---	---
THADA	63892	broad.mit.edu	37	2	43712611	43712611	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43712611delA	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron|THADA_uc010fas.1_Intron|THADA_uc002rsz.2_Intron|THADA_uc010fat.1_Intron|THADA_uc002rta.2_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
THADA	63892	broad.mit.edu	37	2	43768645	43768647	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43768645_43768647delTTT	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron|THADA_uc010fas.1_Intron|THADA_uc002rsz.2_Intron|THADA_uc010fat.1_Intron|THADA_uc002rta.2_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
THADA	63892	broad.mit.edu	37	2	43787527	43787527	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:43787527delA	uc002rsw.3	-						THADA_uc010far.2_Intron|THADA_uc002rsx.3_Intron|THADA_uc002rsy.3_Intron|THADA_uc010fas.1_Intron|THADA_uc002rsz.2_Intron|THADA_uc010fat.1_Intron|THADA_uc002rta.2_Intron|THADA_uc002rtb.1_Intron|THADA_uc002rtc.3_Intron	NM_001083953	NP_001077422			thyroid adenoma associated								binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)																---	---	---	---
LRPPRC	10128	broad.mit.edu	37	2	44175363	44175363	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44175363delA	uc002rtr.2	-						LRPPRC_uc010yob.1_Intron	NM_133259	NP_573566			leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)																---	---	---	---
PPM1B	5495	broad.mit.edu	37	2	44428223	44428223	+	Intron	DEL	A	-	-	rs72277187		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44428223delA	uc002rtt.2	+						PPM1B_uc002rts.2_Intron|PPM1B_uc002rtu.2_Intron|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Intron|PPM1B_uc002rtx.2_Intron	NM_002706	NP_002697			protein phosphatase 1B isoform 1						protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)																---	---	---	---
PREPL	9581	broad.mit.edu	37	2	44550553	44550553	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:44550553delA	uc002ruf.2	-						PREPL_uc002rug.2_Intron|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Intron|PREPL_uc002rui.3_Intron|PREPL_uc002ruj.1_Intron|PREPL_uc002ruk.1_Intron	NM_006036	NP_006027			prolyl endopeptidase-like isoform C						proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)																---	---	---	---
SRBD1	55133	broad.mit.edu	37	2	45812730	45812730	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:45812730delT	uc002rus.2	-							NM_018079	NP_060549			S1 RNA binding domain 1						nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)															---	---	---	---
EPCAM	4072	broad.mit.edu	37	2	47600582	47600582	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47600582delT	uc002rvx.2	+						EPCAM_uc002rvw.2_Intron	NM_002354	NP_002345			epithelial cell adhesion molecule precursor						positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1														Lynch_syndrome				---	---	---	---
MSH6	2956	broad.mit.edu	37	2	48032258	48032259	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:48032258_48032259delAT	uc002rwd.3	+						MSH6_uc010fbj.2_Intron|MSH6_uc010yoi.1_Intron|MSH6_uc010yoj.1_Intron	NM_000179	NP_000170			mutS homolog 6						determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)					Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				---	---	---	---
ASB3	51130	broad.mit.edu	37	2	53897896	53897896	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:53897896delT	uc002rxg.1	-						ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc002rxf.1_Intron	NM_016115	NP_057199			ankyrin repeat and SOCS box-containing protein 3						intracellular signal transduction					ovary(1)|kidney(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54126955	54126955	+	Intron	DEL	A	-	-	rs71408744		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54126955delA	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54163841	54163841	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54163841delG	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
PSME4	23198	broad.mit.edu	37	2	54163848	54163848	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54163848delA	uc002rxp.2	-						PSME4_uc010yop.1_Intron|PSME4_uc010yoq.1_Intron|PSME4_uc010fbu.1_Intron|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429			proteasome (prosome, macropain) activator						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)															---	---	---	---
CCDC88A	55704	broad.mit.edu	37	2	55562391	55562391	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:55562391delA	uc002ryv.2	-						CCDC88A_uc010yoz.1_Intron|CCDC88A_uc010ypa.1_Intron|CCDC88A_uc010ypb.1_Intron|CCDC88A_uc002ryu.2_5'Flank|CCDC88A_uc002ryw.2_5'Flank	NM_001135597	NP_001129069			coiled-coil domain containing 88A isoform 1						activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	58687298	58687298	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:58687298delT								FANCL (218783 upstream) : None (None downstream)																																			---	---	---	---
PAPOLG	64895	broad.mit.edu	37	2	60997758	60997758	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:60997758delT	uc002sai.2	+						PAPOLG_uc002saj.2_Intron|PAPOLG_uc002sak.2_Intron	NM_022894	NP_075045			poly(A) polymerase gamma						mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)															---	---	---	---
REL	5966	broad.mit.edu	37	2	61119084	61119084	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61119084delT	uc002sam.1	+						REL_uc002san.1_Intron	NM_002908	NP_002899			v-rel reticuloendotheliosis viral oncogene						positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)					A		Hodgkin Lymphoma								---	---	---	---
USP34	9736	broad.mit.edu	37	2	61558591	61558591	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61558591delA	uc002sbe.2	-							NM_014709	NP_055524			ubiquitin specific protease 34						positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)															---	---	---	---
XPO1	7514	broad.mit.edu	37	2	61710329	61710329	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:61710329delT	uc002sbj.2	-						XPO1_uc010fcl.2_Intron|XPO1_uc010ypn.1_Intron|XPO1_uc002sbk.2_Intron|XPO1_uc002sbg.2_Intron|XPO1_uc002sbh.2_Intron	NM_003400	NP_003391			exportin 1						intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)															---	---	---	---
UGP2	7360	broad.mit.edu	37	2	64082655	64082655	+	Intron	DEL	T	-	-	rs71393335		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64082655delT	uc002scm.2	+						UGP2_uc002scl.2_Intron|UGP2_uc010ypx.1_Intron	NM_006759	NP_006750			UDP-glucose pyrophosphorylase 2 isoform a						glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0																		---	---	---	---
VPS54	51542	broad.mit.edu	37	2	64124487	64124487	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64124487delA	uc002scq.2	-						VPS54_uc002scp.2_Intron|VPS54_uc002scn.2_Intron|VPS54_uc002sco.2_Intron|VPS54_uc010fct.2_Intron	NM_016516	NP_057600			vacuolar protein sorting 54 isoform 1						protein transport|retrograde transport, endosome to Golgi						0																		---	---	---	---
PELI1	57162	broad.mit.edu	37	2	64331637	64331637	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:64331637delT	uc002scs.3	-						PELI1_uc002sct.3_Intron	NM_020651	NP_065702			pellino protein						innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	65200581	65200581	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:65200581delA								SERTAD2 (319535 upstream) : SLC1A4 (14998 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	65738862	65738863	+	Intron	DEL	TG	-	-	rs35572946		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:65738862_65738863delTG	uc010fcy.1	+											Homo sapiens cDNA FLJ16124 fis, clone BRACE2011677.																														---	---	---	---
AAK1	22848	broad.mit.edu	37	2	69747001	69747001	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:69747001delT	uc002sfp.2	-						AAK1_uc010fdk.2_Intron|AAK1_uc010yqm.1_Intron	NM_014911	NP_055726			AP2 associated kinase 1							coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0																		---	---	---	---
CLEC4F	165530	broad.mit.edu	37	2	71036532	71036532	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71036532delA	uc002shf.2	-						CLEC4F_uc010yqv.1_Intron	NM_173535	NP_775806			C-type lectin, superfamily member 13						endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5																		---	---	---	---
MCEE	84693	broad.mit.edu	37	2	71337212	71337212	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:71337212delT	uc002shs.2	-	3	464	c.419delA	c.(418-420)AAGfs	p.K140fs		NM_032601	NP_115990	Q96PE7	MCEE_HUMAN	methylmalonyl CoA epimerase precursor	140	Poly-Lys.				fatty acid beta-oxidation|L-methylmalonyl-CoA metabolic process	mitochondrial matrix	methylmalonyl-CoA epimerase activity			ovary(1)	1																		---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73829295	73829295	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73829295delT	uc002sje.1	+						ALMS1_uc002sjf.1_Intron|ALMS1_uc002sjh.1_Intron	NM_015120	NP_055935			Alstrom syndrome 1						G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
TET3	200424	broad.mit.edu	37	2	74329152	74329152	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74329152delG	uc002skb.3	+	9	4832	c.4832delG	c.(4831-4833)TGGfs	p.W1611fs		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1611							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0																		---	---	---	---
MOBKL1B	55233	broad.mit.edu	37	2	74394389	74394389	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74394389delT	uc002skh.3	-						MOBKL1B_uc002ski.2_Intron	NM_018221	NP_060691			Mob4B protein						hippo signaling cascade		metal ion binding|protein binding				0																		---	---	---	---
SUCLG1	8802	broad.mit.edu	37	2	84676962	84676962	+	Intron	DEL	A	-	-	rs77955793		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:84676962delA	uc002son.2	-						SUCLG1_uc010ysk.1_Intron	NM_003849	NP_003840			succinate-CoA ligase, GDP-forming alpha subunit						tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity				0					Succinic acid(DB00139)													---	---	---	---
C2orf89	129293	broad.mit.edu	37	2	85097203	85097203	+	Intron	DEL	T	-	-	rs35902901		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85097203delT	uc010ysl.1	-						C2orf89_uc002sou.3_Intron|C2orf89_uc010fgc.1_Intron	NM_001080824	NP_001074293			hypothetical protein LOC129293 precursor							integral to membrane				ovary(1)	1																		---	---	---	---
USP39	10713	broad.mit.edu	37	2	85850600	85850600	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85850600delT	uc002sqe.2	+						USP39_uc002sqb.2_Intron|USP39_uc010ysu.1_Intron|USP39_uc010ysv.1_Intron|USP39_uc010fgn.1_Intron|USP39_uc002sqf.2_Intron|USP39_uc002sqg.2_Intron|USP39_uc010fgo.2_Intron	NM_006590	NP_006581			ubiquitin specific protease 39						spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1																		---	---	---	---
USP39	10713	broad.mit.edu	37	2	85852575	85852576	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85852575_85852576insT	uc002sqe.2	+						USP39_uc002sqb.2_Intron|USP39_uc010ysu.1_Intron|USP39_uc010ysv.1_Intron|USP39_uc010fgn.1_Intron|USP39_uc002sqf.2_Intron|USP39_uc002sqg.2_Intron|USP39_uc010fgo.2_Intron	NM_006590	NP_006581			ubiquitin specific protease 39						spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)	1																		---	---	---	---
IMMT	10989	broad.mit.edu	37	2	86393771	86393772	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86393771_86393772delAA	uc002sqz.3	-						IMMT_uc002sqy.3_Intron|IMMT_uc002srb.3_Intron|IMMT_uc002sra.3_Intron|IMMT_uc010ytd.1_Intron|IMMT_uc010yte.1_Intron|IMMT_uc002src.1_Intron|IMMT_uc002srd.2_Intron|IMMT_uc002sre.3_Intron|IMMT_uc010ytf.1_Intron|IMMT_uc010fgs.1_Intron	NM_006839	NP_006830			inner membrane protein, mitochondrial isoform 1							integral to mitochondrial inner membrane	protein binding			skin(1)	1																		---	---	---	---
MRPL35	51318	broad.mit.edu	37	2	86433464	86433465	+	Intron	INS	-	T	T	rs143801708	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:86433464_86433465insT	uc002srg.3	+						MRPL35_uc002srf.3_Intron	NM_016622	NP_057706			mitochondrial ribosomal protein L35 isoform a						translation	mitochondrial ribosome	structural constituent of ribosome				0																		---	---	---	---
RMND5A	64795	broad.mit.edu	37	2	87566298	87566298	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:87566298delA	uc002srs.3	+											SubName: Full=cDNA FLJ10361 fis, clone NT2RM2001256, highly similar to Anaphase-promoting complex subunit 1;											ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	92145699	92145699	+	IGR	DEL	T	-	-	rs76107118		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:92145699delT								FKSG73 (15205 upstream) : None (None downstream)																																			---	---	---	---
KCNIP3	30818	broad.mit.edu	37	2	95976299	95976299	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:95976299delT	uc002sup.2	+						KCNIP3_uc002suo.1_Frame_Shift_Del_p.V71fs	NM_013434	NP_038462			Kv channel interacting protein 3 isoform 1						apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	96180550	96180551	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96180550_96180551insT								FAHD2A (101672 upstream) : TRIM43 (77215 downstream)																																			---	---	---	---
STARD7	56910	broad.mit.edu	37	2	96852843	96852847	+	Intron	DEL	AAAAA	-	-	rs79652198		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96852843_96852847delAAAAA	uc002svm.3	-						STARD7_uc002svl.2_Intron	NM_020151	NP_064536			START domain containing 7 precursor							mitochondrion					0																		---	---	---	---
SNRNP200	23020	broad.mit.edu	37	2	96955213	96955213	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96955213delT	uc002svu.2	-						SNRNP200_uc002svw.1_Intron	NM_014014	NP_054733			activating signal cointegrator 1 complex subunit							catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10																		---	---	---	---
AFF3	3899	broad.mit.edu	37	2	100623849	100623849	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100623849delA	uc002tag.2	-	5	484	c.248delT	c.(247-249)TTAfs	p.L83fs	AFF3_uc002taf.2_Frame_Shift_Del_p.L108fs|AFF3_uc010fiq.1_Frame_Shift_Del_p.L83fs|AFF3_uc010yvr.1_Frame_Shift_Del_p.L237fs|AFF3_uc002tah.1_Frame_Shift_Del_p.L108fs|AFF3_uc010fir.1_Frame_Shift_Del_p.L160fs|AFF3_uc002tai.2_Frame_Shift_Del_p.L5fs	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	83					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6																		---	---	---	---
LONRF2	164832	broad.mit.edu	37	2	100916473	100916473	+	Intron	DEL	A	-	-	rs2871342	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:100916473delA	uc002tal.3	-						LONRF2_uc010yvs.1_Intron	NM_198461	NP_940863			LON peptidase N-terminal domain and ring finger						proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2																		---	---	---	---
MFSD9	84804	broad.mit.edu	37	2	103347663	103347663	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:103347663delT	uc002tcb.2	-						MFSD9_uc010fja.2_Intron	NM_032718	NP_116107			major facilitator superfamily domain containing						transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4																		---	---	---	---
UXS1	80146	broad.mit.edu	37	2	106710415	106710415	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:106710415delA	uc002tdm.2	-	15					UXS1_uc002tdk.2_3'UTR|UXS1_uc002tdl.2_3'UTR|UXS1_uc002tdn.2_3'UTR|UXS1_uc002tdo.2_3'UTR	NM_025076	NP_079352			UDP-glucuronate decarboxylase 1						cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			ovary(2)	2																		---	---	---	---
RGPD3	653489	broad.mit.edu	37	2	107075791	107075791	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:107075791delA	uc010ywi.1	-							NM_001144013	NP_001137485			RANBP2-like and GRIP domain containing 3						intracellular transport		binding			ovary(1)	1																		---	---	---	---
RGPD4	285190	broad.mit.edu	37	2	108489258	108489258	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:108489258delA	uc010ywk.1	+	20	4880	c.4798delA	c.(4798-4800)AAAfs	p.K1600fs	RGPD4_uc002tdu.2_Frame_Shift_Del_p.K787fs|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1600					intracellular transport		binding			skin(2)	2																		---	---	---	---
GCC2	9648	broad.mit.edu	37	2	109123862	109123862	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109123862delC	uc002tec.2	+						GCC2_uc002ted.2_Intron	NM_181453	NP_852118			GRIP and coiled-coil domain-containing 2						Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109345578	109345578	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109345578delT	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109345679	109345679	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109345679delT	uc002tem.3	+							NM_006267	NP_006258			RAN binding protein 2						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112636586	112636587	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112636586_112636587insT	uc002thi.2	-						ANAPC1_uc002thj.2_Intron	NM_022662	NP_073153			anaphase promoting complex subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
RGPD5	84220	broad.mit.edu	37	2	113157159	113157160	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113157159_113157160delAT	uc002ths.1	-						RGPD8_uc010fkk.1_Intron|RGPD5_uc002tht.1_Intron|RGPD5_uc010yxm.1_Intron	NM_005054	NP_005045			RANBP2-like and GRIP domain containing 5 isoform						intracellular transport	cytoplasm	binding				0																		---	---	---	---
DPP10	57628	broad.mit.edu	37	2	116534869	116534869	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:116534869delA	uc002tla.1	+	14	1764	c.1307delA	c.(1306-1308)CAAfs	p.Q436fs	DPP10_uc002tlb.1_Frame_Shift_Del_p.Q386fs|DPP10_uc002tlc.1_Frame_Shift_Del_p.Q432fs|DPP10_uc002tle.2_Frame_Shift_Del_p.Q440fs|DPP10_uc002tlf.1_Frame_Shift_Del_p.Q429fs	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	436	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10																		---	---	---	---
SCTR	6344	broad.mit.edu	37	2	120219288	120219293	+	Intron	DEL	AAAAAA	-	-	rs67695587		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120219288_120219293delAAAAAA	uc002tma.2	-						SCTR_uc002tlz.2_Intron	NM_002980	NP_002971			secretin receptor precursor						digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)													---	---	---	---
WDR33	55339	broad.mit.edu	37	2	128471001	128471001	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128471001delT	uc002tpg.1	-							NM_018383	NP_060853			WD repeat domain 33 isoform 1						postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)														---	---	---	---
WDR33	55339	broad.mit.edu	37	2	128477624	128477624	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128477624delG	uc002tpg.1	-	16	2158	c.1975delC	c.(1975-1977)CAGfs	p.Q659fs		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	659	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)														---	---	---	---
WDR33	55339	broad.mit.edu	37	2	128480964	128480964	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128480964delT	uc002tpg.1	-							NM_018383	NP_060853			WD repeat domain 33 isoform 1						postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)														---	---	---	---
UGGT1	56886	broad.mit.edu	37	2	128936017	128936018	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:128936017_128936018insT	uc002tps.2	+						UGGT1_uc002tpr.2_Intron	NM_020120	NP_064505			UDP-glucose ceramide glucosyltransferase-like 1						'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	131205215	131205215	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131205215delC								PTPN18 (72234 upstream) : CFC1B (73621 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	132219141	132219141	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132219141delA								LOC401010 (16674 upstream) : TUBA3D (14525 downstream)																																			---	---	---	---
LOC150776	150776	broad.mit.edu	37	2	132259053	132259053	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132259053delG	uc010fna.2	+						LOC150776_uc010zax.1_RNA|LOC150776_uc010zay.1_RNA|LOC150776_uc010zaz.1_RNA|LOC150776_uc002tsy.3_RNA					Homo sapiens cDNA FLJ61219 complete cds, highly similar to Homo sapiens sphingomyelin phosphodiesterase 4, neutral membrane, transcript variant 2, mRNA.												0																		---	---	---	---
NCRNA00164	554226	broad.mit.edu	37	2	132905859	132905860	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132905859_132905860delTT	uc002tti.3	-						NCRNA00164_uc002ttj.3_Intron	NR_027019				Homo sapiens non-protein coding RNA 164, mRNA (cDNA clone IMAGE:5169389), with apparent retained intron.												0																		---	---	---	---
NCKAP5	344148	broad.mit.edu	37	2	133489260	133489260	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:133489260delT	uc002ttp.2	-						NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246			Nck-associated protein 5 isoform 1								protein binding				0																		---	---	---	---
RAB3GAP1	22930	broad.mit.edu	37	2	135887668	135887668	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:135887668delT	uc002tuj.2	+						RAB3GAP1_uc010fnf.2_Intron|RAB3GAP1_uc010fng.2_Intron|RAB3GAP1_uc010fnh.1_Intron	NM_012233	NP_036365			RAB3 GTPase-activating protein							centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)														---	---	---	---
ZRANB3	84083	broad.mit.edu	37	2	136103038	136103039	+	Intron	INS	-	A	A	rs75118467		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136103038_136103039insA	uc002tum.2	-						ZRANB3_uc002tuk.2_Intron|ZRANB3_uc002tul.2_Intron|ZRANB3_uc002tun.1_Intron	NM_032143	NP_115519			zinc finger, RAN-binding domain containing 3							intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)														---	---	---	---
UBXN4	23190	broad.mit.edu	37	2	136536389	136536389	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136536389delT	uc002tur.2	+						UBXN4_uc002tus.2_Intron|UBXN4_uc002tut.2_Intron	NM_014607	NP_055422			UBX domain containing 2						response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			skin(2)	2																		---	---	---	---
MCM6	4175	broad.mit.edu	37	2	136626526	136626526	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136626526delA	uc002tuw.2	-							NM_005915	NP_005906			minichromosome maintenance complex component 6						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)													---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141625542	141625542	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141625542delA	uc002tvj.1	-						LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141773219	141773219	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141773219delA	uc002tvj.1	-						LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027			low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
GTDC1	79712	broad.mit.edu	37	2	144765110	144765110	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:144765110delA	uc002tvp.2	-						GTDC1_uc002tvo.2_Intron|GTDC1_uc002tvq.2_Intron|GTDC1_uc002tvr.2_Intron|GTDC1_uc010fnn.2_Intron|GTDC1_uc002tvs.2_Intron|GTDC1_uc010fno.2_Intron|GTDC1_uc002tvt.1_Intron	NM_001006636	NP_001006637			glycosyltransferase-like domain containing 1						biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)														---	---	---	---
ACVR2A	92	broad.mit.edu	37	2	148680776	148680776	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:148680776delT	uc002twg.2	+						ACVR2A_uc010zbn.1_Intron|ACVR2A_uc002twh.2_Intron	NM_001616	NP_001607			activin A receptor, type IIA precursor						activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152371472	152371472	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152371472delA	uc010fnx.2	-						NEB_uc002txr.2_Intron|NEB_uc002txt.3_Intron	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152497263	152497263	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152497263delA	uc010fnx.2	-						NEB_uc002txu.2_5'Flank	NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
NEB	4703	broad.mit.edu	37	2	152524209	152524209	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152524209delT	uc010fnx.2	-							NM_004543	NP_004534			nebulin isoform 3						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)														---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153515881	153515881	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153515881delA	uc002tyh.3	-						PRPF40A_uc002tyg.3_Intron|PRPF40A_uc010zcd.1_Intron	NM_017892	NP_060362			formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
PRPF40A	55660	broad.mit.edu	37	2	153526848	153526849	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:153526848_153526849insT	uc002tyh.3	-	15	1548_1549	c.1526_1527insA	c.(1525-1527)AACfs	p.N509fs	PRPF40A_uc002tyg.3_5'Flank|PRPF40A_uc010zcd.1_Frame_Shift_Ins_p.N456fs	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3	536	FF 3.				mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	156340381	156340381	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:156340381delT								KCNJ3 (627367 upstream) : NR4A2 (840565 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	2	156889928	156889928	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:156889928delT	uc002tyw.2	-											Homo sapiens cDNA clone IMAGE:5209417.																														---	---	---	---
Unknown	0	broad.mit.edu	37	2	158067413	158067413	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158067413delA								GPD2 (597166 upstream) : GALNT5 (46927 downstream)																																			---	---	---	---
ACVR1C	130399	broad.mit.edu	37	2	158390567	158390567	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:158390567delA	uc002tzk.3	-						ACVR1C_uc002tzl.3_Intron|ACVR1C_uc010fof.2_Intron|ACVR1C_uc010foe.2_Intron	NM_145259	NP_660302			activin A receptor, type IC isoform 1						apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7																		---	---	---	---
TANC1	85461	broad.mit.edu	37	2	159912831	159912831	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:159912831delT	uc002uag.2	+						TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Intron	NM_033394	NP_203752			tetratricopeptide repeat, ankyrin repeat and							cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
BAZ2B	29994	broad.mit.edu	37	2	160252408	160252409	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160252408_160252409insA	uc002uao.2	-						BAZ2B_uc002uap.2_Intron	NM_013450	NP_038478			bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4																		---	---	---	---
LY75	4065	broad.mit.edu	37	2	160667224	160667224	+	Intron	DEL	A	-	-	rs71423030		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160667224delA	uc002ubc.3	-						LY75_uc002ubb.3_Intron|LY75_uc010fos.2_Intron	NM_002349	NP_002340			lymphocyte antigen 75 precursor						endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)														---	---	---	---
PLA2R1	22925	broad.mit.edu	37	2	160843569	160843569	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160843569delA	uc002ube.1	-						PLA2R1_uc010zcp.1_Intron|PLA2R1_uc002ubf.2_Intron	NM_007366	NP_031392			phospholipase A2 receptor 1 isoform 1 precursor						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3																		---	---	---	---
ITGB6	3694	broad.mit.edu	37	2	160968845	160968845	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160968845delT	uc002ubh.2	-						ITGB6_uc010fou.2_Intron|ITGB6_uc010zcq.1_Intron|ITGB6_uc010fov.1_Intron	NM_000888	NP_000879			integrin, beta 6 precursor						cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	162357702	162357702	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162357702delT								TBR1 (76129 upstream) : SLC4A10 (123143 downstream)																																			---	---	---	---
SCN3A	6328	broad.mit.edu	37	2	165971884	165971884	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165971884delT	uc002ucx.2	-						SCN3A_uc002ucy.2_Intron|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Intron|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853			sodium channel, voltage-gated, type III, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)													---	---	---	---
SCN3A	6328	broad.mit.edu	37	2	165996281	165996281	+	Intron	DEL	A	-	-	rs2289400	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:165996281delA	uc002ucx.2	-						SCN3A_uc002ucy.2_Intron|SCN3A_uc002ucz.2_Intron|SCN3A_uc002uda.1_Intron|SCN3A_uc002udb.1_Intron	NM_006922	NP_008853			sodium channel, voltage-gated, type III, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)													---	---	---	---
SCN9A	6335	broad.mit.edu	37	2	167160479	167160479	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:167160479delT	uc010fpl.2	-						SCN9A_uc002udr.1_Intron|SCN9A_uc002uds.1_Intron|SCN9A_uc002udt.1_Intron	NM_002977	NP_002968			sodium channel, voltage-gated, type IX, alpha							voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)													---	---	---	---
NOSTRIN	115677	broad.mit.edu	37	2	169684652	169684652	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:169684652delT	uc002ueg.2	+						NOSTRIN_uc002uef.2_Intron|NOSTRIN_uc002uei.2_Intron|NOSTRIN_uc010fpu.2_Intron|NOSTRIN_uc002ueh.2_Intron|NOSTRIN_uc002uej.2_Intron	NM_001039724	NP_001034813			nitric oxide synthase trafficker isoform 2						endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170033201	170033201	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170033201delA	uc002ues.2	-							NM_004525	NP_004516			low density lipoprotein-related protein 2						hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
KBTBD10	10324	broad.mit.edu	37	2	170344243	170344243	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170344243delT	uc010zdh.1	+						BBS5_uc002uet.2_Intron|BBS5_uc010fpw.2_Intron	NM_152384	NP_689597			Bardet-Biedl syndrome 5						striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0																		---	---	---	---
PPIG	9360	broad.mit.edu	37	2	170489633	170489633	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170489633delA	uc002uez.2	+						PPIG_uc010fpx.2_Intron|PPIG_uc010fpy.2_Intron|PPIG_uc002ufa.2_Intron|PPIG_uc002ufb.2_Intron|PPIG_uc002ufd.2_Intron	NM_004792	NP_004783			peptidylprolyl isomerase G						protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)													---	---	---	---
MYO3B	140469	broad.mit.edu	37	2	171458682	171458682	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171458682delA	uc002ufy.2	+						MYO3B_uc002ufz.2_Intron|MYO3B_uc002ufw.2_Intron|MYO3B_uc002ufx.2_Intron|MYO3B_uc002ugb.2_Intron	NM_138995	NP_620482			myosin IIIB isoform 2						response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19																		---	---	---	---
TLK1	9874	broad.mit.edu	37	2	171910371	171910371	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:171910371delA	uc002ugn.2	-						TLK1_uc002ugo.2_Intron|TLK1_uc002ugp.2_Intron|TLK1_uc002ugq.2_Intron|TLK1_uc010zdn.1_Intron|TLK1_uc002ugr.1_5'UTR	NM_012290	NP_036422			tousled-like kinase 1 isoform 1						cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1																		---	---	---	---
METTL8	79828	broad.mit.edu	37	2	172217029	172217029	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172217029delA	uc010zdo.1	-						METTL8_uc002ugu.3_Intron|METTL8_uc002ugv.3_Intron|METTL8_uc002ugt.3_Intron|METTL8_uc002ugs.3_Intron|METTL8_uc010zdp.1_Intron	NM_024770	NP_079046			methyltransferase like 8								methyltransferase activity			ovary(1)	1																		---	---	---	---
HAT1	8520	broad.mit.edu	37	2	172809273	172809273	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:172809273delT	uc002uhi.2	+						HAT1_uc010fqi.2_Intron|HAT1_uc002uhj.2_Intron	NM_003642	NP_003633			histone acetyltransferase 1						chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)															---	---	---	---
ITGA6	3655	broad.mit.edu	37	2	173337670	173337670	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173337670delT	uc002uhp.1	+						ITGA6_uc010fqk.1_Intron|ITGA6_uc010zdy.1_Intron|ITGA6_uc002uho.1_Intron|ITGA6_uc010fqm.1_5'Flank	NM_001079818	NP_001073286			integrin alpha chain, alpha 6 isoform a						blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0979)															---	---	---	---
RAPGEF4	11069	broad.mit.edu	37	2	173662239	173662240	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173662239_173662240delTT	uc002uhv.3	+						RAPGEF4_uc002uhu.2_Intron|RAPGEF4_uc010fqn.2_Intron	NM_007023	NP_008954			Rap guanine nucleotide exchange factor (GEF) 4						blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)															---	---	---	---
ZAK	51776	broad.mit.edu	37	2	174123373	174123373	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174123373delA	uc002uhz.2	+						uc002uib.2_Intron	NM_016653	NP_057737			MLK-related kinase isoform 1						activation of JUN kinase activity|activation of MAPKK activity|cell cycle arrest|cell death|cell differentiation|cell proliferation|DNA damage checkpoint|positive regulation of apoptosis|response to radiation	cytoplasm|nucleus	ATP binding|identical protein binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			lung(3)|stomach(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.176)															---	---	---	---
CDCA7	83879	broad.mit.edu	37	2	174230973	174230973	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:174230973delG	uc002uid.1	+						CDCA7_uc002uic.1_Intron|CDCA7_uc010zej.1_Intron|CDCA7_uc010zek.1_Intron	NM_145810	NP_665809			cell division cycle associated 7 isoform 2						regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)															---	---	---	---
HOXD8	3234	broad.mit.edu	37	2	176996016	176996017	+	Intron	DEL	CC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176996016_176996017delCC	uc002uko.2	+						uc002ukl.1_5'Flank|uc002ukm.1_5'Flank|HOXD8_uc002ukn.2_Intron|HOXD8_uc002ukp.2_Intron	NM_019558	NP_062458			homeobox D8						anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)														---	---	---	---
HOXD1	3231	broad.mit.edu	37	2	177054232	177054232	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177054232delC	uc002ukv.3	+						HOXD1_uc010fqy.2_Intron|HOXD1_uc010zez.1_Intron	NM_024501	NP_078777			homeobox D1							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	177065588	177065588	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:177065588delT								HOXD1 (9953 upstream) : MTX2 (68535 downstream)																																			---	---	---	---
OSBPL6	114880	broad.mit.edu	37	2	179258982	179258982	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179258982delT	uc002ulx.2	+						OSBPL6_uc002uly.2_Intron|OSBPL6_uc010zfe.1_Intron|OSBPL6_uc002ulz.2_Intron|OSBPL6_uc002uma.2_Intron	NM_032523	NP_115912			oxysterol-binding protein-like protein 6 isoform						lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179392052	179392052	+	Intron	DEL	A	-	-	rs148707308		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179392052delA	uc010zfg.1	-						uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umq.2_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179554381	179554381	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179554381delT	uc010zfg.1	-						TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron	NM_133378	NP_596869			titin isoform N2-A								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179590725	179590725	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179590725delT	uc010zfg.1	-	67	16816	c.16592delA	c.(16591-16593)AATfs	p.N5531fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.N2192fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6458							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
UBE2E3	10477	broad.mit.edu	37	2	181925322	181925322	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:181925322delT	uc002unq.1	+						UBE2E3_uc002unr.1_Intron|UBE2E3_uc010fri.1_Intron	NM_182678	NP_872619			ubiquitin-conjugating enzyme E2E 3						protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	186821298	186821298	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:186821298delT								None (None upstream) : ZC3H15 (529587 downstream)																																			---	---	---	---
ZC3H15	55854	broad.mit.edu	37	2	187370150	187370150	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:187370150delA	uc002upo.2	+							NM_018471	NP_060941			erythropoietin 4 immediate early response							cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)															---	---	---	---
DIRC1	116093	broad.mit.edu	37	2	189599261	189599261	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:189599261delA	uc002uqi.1	-	2						NM_052952	NP_443184			disrupted in renal carcinoma 1												0			OV - Ovarian serous cystadenocarcinoma(117;0.00842)|Epithelial(96;0.102)															---	---	---	---
Unknown	0	broad.mit.edu	37	2	190175919	190175919	+	IGR	DEL	T	-	-	rs79891507		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190175919delT								COL5A2 (131314 upstream) : WDR75 (130240 downstream)																																			---	---	---	---
WDR75	84128	broad.mit.edu	37	2	190320338	190320338	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190320338delT	uc002uql.1	+						WDR75_uc002uqm.1_Intron|WDR75_uc002uqn.1_Intron|WDR75_uc002uqo.1_5'Flank	NM_032168	NP_115544			WD repeat domain 75							nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)															---	---	---	---
PMS1	5378	broad.mit.edu	37	2	190717591	190717591	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:190717591delA	uc002urh.3	+						PMS1_uc010zga.1_Intron|PMS1_uc010zgb.1_Intron|PMS1_uc002urk.3_Intron|PMS1_uc002uri.3_Intron|PMS1_uc010zgc.1_Intron|PMS1_uc010zgd.1_Intron|PMS1_uc002urj.2_Intron|PMS1_uc010fry.1_Intron|PMS1_uc010frz.2_Intron|PMS1_uc002url.2_Intron|PMS1_uc002urm.2_Intron|PMS1_uc002urn.1_5'Flank	NM_000534	NP_000525			postmeiotic segregation 1 isoform a						mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)					Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					---	---	---	---
STAT1	6772	broad.mit.edu	37	2	191843824	191843824	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191843824delA	uc002usj.2	-						STAT1_uc010fse.1_Intron|STAT1_uc002usk.2_Intron|STAT1_uc002usl.2_Intron	NM_007315	NP_009330			signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)													---	---	---	---
STAT4	6775	broad.mit.edu	37	2	191896272	191896272	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:191896272delA	uc002usm.1	-						STAT4_uc002usn.1_Intron|STAT4_uc010zgk.1_Intron	NM_003151	NP_003142			signal transducer and activator of transcription						JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)															---	---	---	---
TMEFF2	23671	broad.mit.edu	37	2	192922645	192922645	+	Intron	DEL	T	-	-	rs79305372		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:192922645delT	uc002utc.2	-							NM_016192	NP_057276			transmembrane protein with EGF-like and two							extracellular region|integral to membrane				lung(2)|pancreas(1)|breast(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.0835)															---	---	---	---
DNAH7	56171	broad.mit.edu	37	2	196602560	196602560	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:196602560delA	uc002utj.3	-	65					DNAH7_uc002uti.3_3'UTR	NM_018897	NP_061720			dynein, axonemal, heavy chain 7						ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12																		---	---	---	---
SF3B1	23451	broad.mit.edu	37	2	198262678	198262678	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198262678delT	uc002uue.2	-							NM_012433	NP_036565			splicing factor 3b, subunit 1 isoform 1						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)															---	---	---	---
HSPD1	3329	broad.mit.edu	37	2	198359954	198359954	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198359954delA	uc002uui.2	-						HSPD1_uc002uuj.2_Intron|HSPD1_uc010zgx.1_Intron|HSPD1_uc010fsm.2_5'UTR|HSPD1_uc002uuk.2_Intron	NM_002156	NP_002147			chaperonin						'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)															---	---	---	---
BOLL	66037	broad.mit.edu	37	2	198593345	198593345	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:198593345delA	uc002uus.2	-						uc002uup.2_Intron|BOLL_uc002uur.2_Intron|BOLL_uc002uut.2_Intron|BOLL_uc010zha.1_Intron|BOLL_uc002uuu.1_Intron	NM_033030	NP_149019			boule isoform 2						cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			ovary(2)	2																		---	---	---	---
SGOL2	151246	broad.mit.edu	37	2	201397676	201397676	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201397676delT	uc002uvw.2	+						SGOL2_uc002uvv.3_Intron|SGOL2_uc010zhd.1_Intron|SGOL2_uc010zhe.1_Intron	NM_152524	NP_689737			shugoshin-like 2 isoform 1						cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4																		---	---	---	---
FAM126B	285172	broad.mit.edu	37	2	201931967	201931967	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201931967delA	uc002uws.3	-						FAM126B_uc002uwu.2_Intron|FAM126B_uc002uwv.2_Intron|FAM126B_uc002uww.1_Intron	NM_173822	NP_776183			hypothetical protein LOC285172							intracellular				ovary(1)	1																		---	---	---	---
CASP10	843	broad.mit.edu	37	2	202060412	202060412	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202060412delT	uc002uxl.1	+						CASP10_uc002uxi.1_Intron|CASP10_uc010zhn.1_Intron|CASP10_uc002uxj.1_Intron|CASP10_uc002uxk.1_Intron|CASP10_uc010fta.1_Intron|CASP10_uc002uxm.1_Intron|CASP10_uc010ftb.1_Intron	NM_032974	NP_116756			caspase 10 isoform b preproprotein						apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6																		---	---	---	---
TRAK2	66008	broad.mit.edu	37	2	202257823	202257823	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202257823delA	uc002uyb.3	-							NM_015049	NP_055864			trafficking protein, kinesin binding 2							early endosome|plasma membrane	GABA receptor binding				0																		---	---	---	---
ALS2	57679	broad.mit.edu	37	2	202588219	202588219	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202588219delA	uc002uyo.2	-						ALS2_uc002uyp.3_Intron|ALS2_uc010ftl.2_Intron	NM_020919	NP_065970			alsin isoform 1						cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7																		---	---	---	---
CDK15	65061	broad.mit.edu	37	2	202672518	202672518	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202672518delA	uc002uyt.2	+						CDK15_uc010ftm.2_Intron|CDK15_uc002uys.2_Intron|CDK15_uc010ftn.1_Intron|CDK15_uc010fto.1_Intron	NM_139158	NP_631897			PFTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)													---	---	---	---
CDK15	65061	broad.mit.edu	37	2	202698437	202698444	+	Intron	DEL	TTCTTTTT	-	-	rs10597284		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202698437_202698444delTTCTTTTT	uc002uyt.2	+						CDK15_uc010ftm.2_Intron|CDK15_uc002uys.2_Intron|CDK15_uc010ftn.1_Intron|CDK15_uc010fto.1_Intron	NM_139158	NP_631897			PFTAIRE protein kinase 2								ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)													---	---	---	---
SUMO1	7341	broad.mit.edu	37	2	203096349	203096349	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203096349delA	uc002uyz.1	-						SUMO1_uc002uza.1_Intron	NM_001005781	NP_001005781			SMT3 suppressor of mif two 3 homolog 1 isoform a						DNA repair|interferon-gamma-mediated signaling pathway|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|palate development|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein complex assembly|protein sumoylation|regulation of interferon-gamma-mediated signaling pathway|regulation of protein localization	cytoplasm|nuclear membrane|nuclear pore|nuclear speck	ubiquitin protein ligase binding				0																		---	---	---	---
NOP58	51602	broad.mit.edu	37	2	203165008	203165009	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203165008_203165009insA	uc002uzb.2	+	13	1470_1471	c.1320_1321insA	c.(1318-1323)TCTAAAfs	p.S440fs		NM_015934	NP_057018	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein homolog	440_441	Lys-rich.				cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding				0																		---	---	---	---
FAM117B	150864	broad.mit.edu	37	2	203624121	203624121	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:203624121delT	uc010zhx.1	+							NM_173511	NP_775782			amyotrophic lateral sclerosis 2 (juvenile)											ovary(1)	1																		---	---	---	---
ABI2	10152	broad.mit.edu	37	2	204275992	204275992	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204275992delT	uc002vaa.2	+						ABI2_uc002uzz.2_Intron|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Intron|ABI2_uc010zij.1_Intron|ABI2_uc002vab.2_Intron|ABI2_uc010zik.1_Intron|ABI2_uc010zil.1_Intron|ABI2_uc010zim.1_Intron|ABI2_uc002vac.2_Intron|ABI2_uc010zin.1_Intron	NM_005759	NP_005750			abl interactor 2						actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0																		---	---	---	---
CTLA4	1493	broad.mit.edu	37	2	204736022	204736022	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:204736022delT	uc002vak.1	+						CTLA4_uc002val.1_Intron|CTLA4_uc010fty.1_Intron|CTLA4_uc010ftz.1_Intron	NM_005214	NP_005205			cytotoxic T-lymphocyte-associated protein 4						B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm					0					Abatacept(DB01281)													---	---	---	---
NRP2	8828	broad.mit.edu	37	2	206659845	206659845	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:206659845delT	uc002vaw.2	+	17					NRP2_uc002vax.2_3'UTR|NRP2_uc002vay.2_3'UTR	NM_201266	NP_957718			neuropilin 2 isoform 1 precursor						angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
NDUFS1	4719	broad.mit.edu	37	2	207012155	207012155	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207012155delA	uc002vbe.2	-						NDUFS1_uc010ziq.1_Intron|NDUFS1_uc010zir.1_Intron|NDUFS1_uc010zis.1_Intron|NDUFS1_uc010zit.1_Intron|NDUFS1_uc010ziu.1_Intron	NM_005006	NP_004997			NADH dehydrogenase (ubiquinone) Fe-S protein 1,						apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
ZDBF2	57683	broad.mit.edu	37	2	207174428	207174428	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:207174428delA	uc002vbp.2	+	5	5426	c.5176delA	c.(5176-5178)AAAfs	p.K1726fs		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1726							nucleic acid binding|zinc ion binding			ovary(3)	3																		---	---	---	---
KLF7	8609	broad.mit.edu	37	2	208030440	208030440	+	5'UTR	DEL	A	-	-	rs71412410		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:208030440delA	uc002vbz.1	-	1					KLF7_uc002vca.1_Intron	NM_003709	NP_003700			Kruppel-like factor 7 (ubiquitous)						regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			central_nervous_system(1)|skin(1)	2				LUSC - Lung squamous cell carcinoma(261;0.0856)|Lung(261;0.166)|Epithelial(149;0.173)														---	---	---	---
RPE	6120	broad.mit.edu	37	2	210880914	210880914	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210880914delT	uc002vdn.2	+						RPE_uc002vdm.2_Intron|RPE_uc002vdo.2_Intron|RPE_uc010zjf.1_Intron|RPE_uc002vdp.2_Intron|RPE_uc010fup.2_Intron|RPE_uc002vdq.2_Intron|RPE_uc002vdr.2_Intron	NM_199229	NP_954699			ribulose-5-phosphate-3-epimerase isoform 1						pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity				0				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)														---	---	---	---
ERBB4	2066	broad.mit.edu	37	2	213403362	213403362	+	5'Flank	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:213403362delG	uc002veg.1	-						ERBB4_uc002veh.1_5'Flank|ERBB4_uc010zji.1_5'Flank|ERBB4_uc010zjj.1_5'Flank|ERBB4_uc010fut.1_5'Flank	NM_005235	NP_005226			v-erb-a erythroblastic leukemia viral oncogene						cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)											TSP Lung(8;0.080)			---	---	---	---
BARD1	580	broad.mit.edu	37	2	215661630	215661630	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:215661630delT	uc002veu.2	-						BARD1_uc010zjm.1_Intron	NM_000465	NP_000456			BRCA1 associated RING domain 1						cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)										Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---	---
ATIC	471	broad.mit.edu	37	2	216184275	216184275	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216184275delT	uc002vex.3	+						ATIC_uc010zjo.1_Intron|ATIC_uc002vey.3_Intron	NM_004044	NP_004035			5-aminoimidazole-4-carboxamide ribonucleotide						IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)			T	ALK	ALCL								---	---	---	---
FN1	2335	broad.mit.edu	37	2	216251710	216251710	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216251710delA	uc002vfa.2	-						FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Intron|FN1_uc002vfj.2_Intron|FN1_uc002vez.2_Intron|FN1_uc010zjp.1_Intron	NM_212482	NP_997647			fibronectin 1 isoform 1 preproprotein						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
FN1	2335	broad.mit.edu	37	2	216295678	216295678	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216295678delT	uc002vfa.2	-						FN1_uc002vfb.2_Intron|FN1_uc002vfc.2_Intron|FN1_uc002vfd.2_Intron|FN1_uc002vfe.2_Intron|FN1_uc002vff.2_Intron|FN1_uc002vfg.2_Intron|FN1_uc002vfh.2_Intron|FN1_uc002vfi.2_Intron|FN1_uc002vfj.2_Intron|FN1_uc002vfl.2_Intron	NM_212482	NP_997647			fibronectin 1 isoform 1 preproprotein						acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
USP37	57695	broad.mit.edu	37	2	219330590	219330590	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219330590delT	uc002vie.2	-						USP37_uc010fvs.1_Intron|USP37_uc010zkf.1_Intron|USP37_uc002vif.2_Intron|USP37_uc002vig.2_Intron	NM_020935	NP_065986			ubiquitin specific peptidase 37						ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)														---	---	---	---
WNT10A	80326	broad.mit.edu	37	2	219746809	219746810	+	Intron	DEL	AG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219746809_219746810delAG	uc002vjd.1	+							NM_025216	NP_079492			wingless-type MMTV integration site family,						anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			lung(1)|skin(1)	2		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
PTPRN	5798	broad.mit.edu	37	2	220165023	220165023	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220165023delG	uc002vkz.2	-						PTPRN_uc010zlc.1_Intron|PTPRN_uc002vla.2_Intron	NM_002846	NP_002837			protein tyrosine phosphatase, receptor type, N						response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220342904	220342905	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220342904_220342905insT	uc010fwg.2	+							NM_005876	NP_005867			SPEG complex locus						muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220345510	220345510	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220345510delC	uc010fwg.2	+							NM_005876	NP_005867			SPEG complex locus						muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
SPEG	10290	broad.mit.edu	37	2	220346200	220346200	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220346200delC	uc010fwg.2	+							NM_005876	NP_005867			SPEG complex locus						muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)														---	---	---	---
FARSB	10056	broad.mit.edu	37	2	223505480	223505480	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:223505480delA	uc002vne.1	-						FARSB_uc010zlq.1_Intron|FARSB_uc002vnf.1_Intron	NM_005687	NP_005678			phenylalanyl-tRNA synthetase, beta subunit						phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)													---	---	---	---
AGFG1	3267	broad.mit.edu	37	2	228388444	228388444	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228388444delT	uc002vpc.2	+						AGFG1_uc002vpd.2_Intron|AGFG1_uc002vpe.2_Intron|AGFG1_uc002vpf.2_Intron	NM_004504	NP_004495			HIV-1 Rev binding protein isoform 2						cell differentiation|mRNA export from nucleus|multicellular organismal development|regulation of ARF GTPase activity|spermatogenesis	cytoplasmic membrane-bounded vesicle|Golgi apparatus|nuclear pore	ARF GTPase activator activity|DNA binding|protein binding|RNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
TRIP12	9320	broad.mit.edu	37	2	230652431	230652431	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:230652431delA	uc002vpw.1	-						TRIP12_uc002vpx.1_Intron|TRIP12_uc002vpy.1_Intron	NM_004238	NP_004229			thyroid hormone receptor interactor 12						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)														---	---	---	---
PSMD1	5707	broad.mit.edu	37	2	231951932	231951933	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231951932_231951933insT	uc002vrn.1	+						PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron	NM_002807	NP_002798			proteasome 26S non-ATPase subunit 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)													---	---	---	---
NCL	4691	broad.mit.edu	37	2	232325316	232325319	+	Intron	DEL	ACAA	-	-	rs141812937	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232325316_232325319delACAA	uc002vru.2	-						SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372			nucleolin						angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding			ovary(2)|pancreas(1)	3		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)														---	---	---	---
Unknown	0	broad.mit.edu	37	2	232451696	232451696	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:232451696delA								NMUR1 (56514 upstream) : C2orf57 (5916 downstream)																																			---	---	---	---
ATG16L1	55054	broad.mit.edu	37	2	234171720	234171720	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234171720delT	uc002vty.2	+						ATG16L1_uc002vtx.1_Intron|ATG16L1_uc002vua.2_Intron|ATG16L1_uc002vub.2_Intron|ATG16L1_uc002vtz.2_Intron|ATG16L1_uc002vud.3_Intron	NM_030803	NP_110430			APG16 autophagy 16-like isoform 1						autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)														---	---	---	---
UGT1A8	54576	broad.mit.edu	37	2	234526224	234526226	+	5'Flank	DEL	TTT	-	-	rs72113678		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:234526224_234526226delTTT	uc002vup.2	+						UGT1A8_uc010zmv.1_5'Flank	NM_019076	NP_061949			UDP glycosyltransferase 1 family, polypeptide A8						drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)												OREG0003838	type=REGULATORY REGION|Gene=UGT1A8|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
IQCA1	79781	broad.mit.edu	37	2	237395459	237395459	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:237395459delA	uc002vvz.1	-						IQCA1_uc002vwb.2_Intron|IQCA1_uc002vwa.1_Intron|IQCA1_uc010zni.1_Intron	NM_024726	NP_079002			IQ motif containing with AAA domain 1								ATP binding			ovary(1)	1																		---	---	---	---
COL6A3	1293	broad.mit.edu	37	2	238277153	238277153	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:238277153delA	uc002vwl.2	-						COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron	NM_004369	NP_004360			alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)														---	---	---	---
ILKAP	80895	broad.mit.edu	37	2	239079047	239079047	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239079047delA	uc002vxv.2	-	12					ILKAP_uc010zns.1_3'UTR|ILKAP_uc002vxw.2_3'UTR	NM_030768	NP_110395			integrin-linked kinase-associated protein							cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			ovary(3)	3		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239168597	239168597	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239168597delT	uc002vyc.2	-						PER2_uc010znv.1_Intron	NM_022817	NP_073728			period 2						circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
FARP2	9855	broad.mit.edu	37	2	242344083	242344084	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:242344083_242344084insG	uc002wbi.1	+						FARP2_uc010zoq.1_Intron|FARP2_uc010zor.1_Intron	NM_014808	NP_055623			FERM, RhoGEF and pleckstrin domain protein 2						axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)														---	---	---	---
CHL1	10752	broad.mit.edu	37	3	424418	424418	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:424418delA	uc003bou.2	+						CHL1_uc003bot.2_Intron|CHL1_uc003bow.1_Intron|CHL1_uc011asi.1_Intron|uc003box.1_Intron	NM_006614	NP_006605			cell adhesion molecule with homology to L1CAM						axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)														---	---	---	---
CRBN	51185	broad.mit.edu	37	3	3197991	3197991	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:3197991delA	uc003bpq.2	-						CRBN_uc003bpr.2_Intron|CRBN_uc010hbw.2_Intron|CRBN_uc011aso.1_Intron	NM_016302	NP_057386			cereblon						proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			ovary(1)	1				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)														---	---	---	---
SLC6A11	6538	broad.mit.edu	37	3	10861469	10861469	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10861469delT	uc003bvz.2	+	3	498	c.464delT	c.(463-465)ATTfs	p.I155fs	SLC6A11_uc003bvy.1_Frame_Shift_Del_p.I155fs	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	155	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	11920306	11920306	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:11920306delT								C3orf31 (31954 upstream) : SYN2 (125556 downstream)																																			---	---	---	---
TMEM40	55287	broad.mit.edu	37	3	12791467	12791467	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12791467delA	uc003bxg.1	-						TMEM40_uc003bxh.1_Intron|TMEM40_uc003bxi.1_Intron|TMEM40_uc011auv.1_Intron	NM_018306	NP_060776			transmembrane protein 40							integral to membrane					0																		---	---	---	---
METTL6	131965	broad.mit.edu	37	3	15455535	15455535	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15455535delA	uc003bzs.1	-	5	924	c.666delT	c.(664-666)TTTfs	p.F222fs	METTL6_uc011avp.1_Frame_Shift_Del_p.F177fs|METTL6_uc010hen.1_Frame_Shift_Del_p.F26fs	NM_152396	NP_689609	Q8TCB7	METL6_HUMAN	methyltransferase like 6	222							methyltransferase activity				0																		---	---	---	---
ANKRD28	23243	broad.mit.edu	37	3	15717504	15717504	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:15717504delA	uc003caj.1	-						ANKRD28_uc003cai.1_Intron|ANKRD28_uc011avz.1_Intron|ANKRD28_uc003cak.1_Intron|ANKRD28_uc011avy.1_Frame_Shift_Del_p.S6fs	NM_015199	NP_056014			ankyrin repeat domain 28							nucleoplasm	protein binding			breast(1)	1																		---	---	---	---
EFHB	151651	broad.mit.edu	37	3	19962069	19962069	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:19962069delA	uc003cbl.3	-						EFHB_uc003cbm.2_Intron	NM_144715	NP_653316			EF hand domain family, member B						signal transduction	proteinaceous extracellular matrix	calcium ion binding				0																		---	---	---	---
KAT2B	8850	broad.mit.edu	37	3	20156336	20156336	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:20156336delT	uc003cbq.2	+							NM_003884	NP_003875			K(lysine) acetyltransferase 2B						cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	23699244	23699247	+	IGR	DEL	AGAG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:23699244_23699247delAGAG								UBE2E2 (66948 upstream) : UBE2E1 (148192 downstream)																																			---	---	---	---
UBE2E1	7324	broad.mit.edu	37	3	23930593	23930593	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:23930593delT	uc003cch.2	+						UBE2E1_uc003cci.2_Intron|UBE2E1_uc011awh.1_Intron	NM_003341	NP_003332			ubiquitin-conjugating enzyme E2E 1 isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|histone H2B ubiquitination|histone monoubiquitination|ISG15-protein conjugation|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K48-linked ubiquitination	cytosol|nucleoplasm|ubiquitin ligase complex	ATP binding|ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
NR1D2	9975	broad.mit.edu	37	3	24009249	24009249	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:24009249delT	uc003ccs.2	+						NR1D2_uc010hfd.2_Intron|NR1D2_uc011awk.1_Intron	NM_005126	NP_005117			nuclear receptor subfamily 1, group D, member 2						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	27047737	27047738	+	IGR	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:27047737_27047738delTT								LRRC3B (295474 upstream) : NEK10 (104657 downstream)																																			---	---	---	---
ZCWPW2	152098	broad.mit.edu	37	3	28476557	28476557	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28476557delT	uc003ceh.2	+						ZCWPW2_uc003cei.2_Intron|ZCWPW2_uc010hfo.2_5'Flank	NM_001040432	NP_001035522			zinc finger, CW type with PWWP domain 2								zinc ion binding			ovary(2)	2																		---	---	---	---
ZCWPW2	152098	broad.mit.edu	37	3	28557191	28557191	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:28557191delA	uc003ceh.2	+						ZCWPW2_uc003cei.2_Intron|ZCWPW2_uc010hfo.2_Intron	NM_001040432	NP_001035522			zinc finger, CW type with PWWP domain 2								zinc ion binding			ovary(2)	2																		---	---	---	---
OSBPL10	114884	broad.mit.edu	37	3	31710397	31710397	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:31710397delT	uc003cev.2	-						OSBPL10_uc003ceu.1_Intron|OSBPL10_uc011axf.1_Intron	NM_017784	NP_060254			oxysterol-binding protein-like protein 10						lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)														---	---	---	---
Unknown	0	broad.mit.edu	37	3	32677112	32677112	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32677112delA								DYNC1LI1 (64762 upstream) : CNOT10 (49586 downstream)																																			---	---	---	---
GLB1	2720	broad.mit.edu	37	3	33065729	33065729	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33065729delT	uc003cfi.1	-						GLB1_uc003cfh.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron	NM_000404	NP_000395			galactosidase, beta 1 isoform a preproprotein						carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)																---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33602361	33602361	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33602361delT	uc003cfu.2	-	27	3223	c.2869delA	c.(2869-2871)ATGfs	p.M957fs	CLASP2_uc003cfs.2_Frame_Shift_Del_p.M164fs|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Frame_Shift_Del_p.M557fs	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	966										ovary(3)|central_nervous_system(1)	4																		---	---	---	---
CLASP2	23122	broad.mit.edu	37	3	33648824	33648824	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:33648824delT	uc003cfu.2	-						CLASP2_uc003cft.2_Intron|CLASP2_uc010hgb.2_Intron|CLASP2_uc003cfv.2_Intron|CLASP2_uc011axu.1_Intron|CLASP2_uc003cfw.2_Intron|CLASP2_uc011axt.1_Intron	NM_015097	NP_055912			CLIP-associating protein 2											ovary(3)|central_nervous_system(1)	4																		---	---	---	---
ARPP21	10777	broad.mit.edu	37	3	35729113	35729113	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:35729113delA	uc003cgb.2	+						ARPP21_uc003cga.2_Intron|ARPP21_uc011axy.1_Intron|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384			cyclic AMP-regulated phosphoprotein, 21 kD							cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	37238346	37238346	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:37238346delA								LRRFIP2 (20495 upstream) : GOLGA4 (46392 downstream)																																			---	---	---	---
VILL	50853	broad.mit.edu	37	3	38048416	38048417	+	Intron	DEL	CT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38048416_38048417delCT	uc003chj.2	+						VILL_uc003chl.2_Intron	NM_015873	NP_056957			villin-like protein						actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)														---	---	---	---
OXSR1	9943	broad.mit.edu	37	3	38263189	38263189	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38263189delT	uc003chy.2	+						OXSR1_uc010hhb.2_Intron|OXSR1_uc010hha.1_Intron	NM_005109	NP_005100			oxidative-stress responsive 1						intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)														---	---	---	---
SCN10A	6336	broad.mit.edu	37	3	38835097	38835097	+	Intron	DEL	A	-	-	rs72869618		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38835097delA	uc003ciq.2	-							NM_006514	NP_006505			sodium channel, voltage-gated, type X, alpha						sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)													---	---	---	---
SCN11A	11280	broad.mit.edu	37	3	38951531	38951531	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38951531delA	uc011ays.1	-							NM_014139	NP_054858			sodium channel, voltage-gated, type XI, alpha						response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)													---	---	---	---
CTNNB1	1499	broad.mit.edu	37	3	41265503	41265503	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41265503delT	uc010hia.1	+						CTNNB1_uc003ckp.2_Intron|CTNNB1_uc003ckq.2_Intron|CTNNB1_uc003ckr.2_Intron|CTNNB1_uc011azf.1_Intron|CTNNB1_uc011azg.1_Intron|uc010hib.1_Intron	NM_001904	NP_001895			beta-catenin						adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.A5_A80del(2)|p.?(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				---	---	---	---
ULK4	54986	broad.mit.edu	37	3	41704969	41704970	+	Intron	INS	-	A	A	rs149124544	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:41704969_41704970insA	uc003ckv.3	-							NM_017886	NP_060356			unc-51-like kinase 4								ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)														---	---	---	---
NKTR	4820	broad.mit.edu	37	3	42679036	42679036	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:42679036delC	uc003clo.2	+	13	1987	c.1840delC	c.(1840-1842)CCCfs	p.P614fs	NKTR_uc003clm.1_Frame_Shift_Del_p.P361fs|NKTR_uc003clp.2_Frame_Shift_Del_p.P361fs|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Frame_Shift_Del_p.P504fs|NKTR_uc003clr.1_Frame_Shift_Del_p.P361fs|NKTR_uc003cls.2_Frame_Shift_Del_p.P314fs	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	614					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)														---	---	---	---
C3orf23	285343	broad.mit.edu	37	3	44438407	44438407	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44438407delA	uc010him.2	+						C3orf23_uc003cnd.3_Intron|C3orf23_uc003cne.3_Intron	NM_173826	NP_776187			hypothetical protein LOC285343 isoform 1							mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)														---	---	---	---
KIF15	56992	broad.mit.edu	37	3	44868019	44868019	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:44868019delT	uc003cnx.3	+						KIF15_uc010hiq.2_Intron|KIF15_uc010hir.2_Intron	NM_020242	NP_064627			kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)														---	---	---	---
LTF	4057	broad.mit.edu	37	3	46487850	46487850	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46487850delT	uc003cpq.2	-						LTF_uc003fzr.2_Intron|LTF_uc010hjh.2_Intron|LTF_uc003cpr.2_Intron	NM_002343	NP_002334			lactotransferrin precursor						cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)													---	---	---	---
LTF	4057	broad.mit.edu	37	3	46491528	46491528	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46491528delA	uc003cpq.2	-						LTF_uc003fzr.2_Intron|LTF_uc010hjh.2_Intron|LTF_uc003cpr.2_Intron	NM_002343	NP_002334			lactotransferrin precursor						cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)													---	---	---	---
PTH1R	5745	broad.mit.edu	37	3	46945264	46945264	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46945264delA	uc003cqm.2	+	16					PTH1R_uc003cqn.2_3'UTR	NM_000316	NP_000307			parathyroid hormone receptor 1 precursor							cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1														Ollier_disease_/_Maffuci_syndrome				---	---	---	---
SETD2	29072	broad.mit.edu	37	3	47103754	47103755	+	Frame_Shift_Ins	INS	-	TC	TC			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47103754_47103755insTC	uc003cqs.2	-	14	6244_6245	c.6191_6192insGA	c.(6190-6192)GACfs	p.D2064fs	SETD2_uc003cqv.2_Frame_Shift_Ins_p.D2131fs|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2064					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)				N|F|S|Mis		clear cell renal carcinoma								---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47677558	47677559	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47677558_47677559insT	uc003crq.2	-	23	2562_2563	c.2444_2445insA	c.(2443-2445)AATfs	p.N815fs	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Frame_Shift_Ins_p.N706fs	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	815	Glu-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
LAMB2	3913	broad.mit.edu	37	3	49169164	49169164	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49169164delG	uc003cwe.2	-						LAMB2_uc003cwf.1_Intron	NM_002292	NP_002283			laminin, beta 2 precursor						cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)														---	---	---	---
C3orf62	375341	broad.mit.edu	37	3	49308392	49308392	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49308392delA	uc003cwn.2	-	3					C3orf62_uc003cwm.2_3'UTR	NM_198562	NP_940964			hypothetical protein LOC375341												0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)														---	---	---	---
USP4	7375	broad.mit.edu	37	3	49343050	49343050	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49343050delA	uc003cwq.2	-						USP4_uc003cwo.2_Intron|USP4_uc003cwp.2_Intron|USP4_uc003cwr.2_Intron	NM_003363	NP_003354			ubiquitin specific protease 4 isoform a						negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)														---	---	---	---
RBM6	10180	broad.mit.edu	37	3	50095229	50095230	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50095229_50095230insA	uc003cyc.2	+	9	1895_1896	c.1762_1763insA	c.(1762-1764)GAAfs	p.E588fs	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Frame_Shift_Ins_p.E107fs|RBM6_uc003cyd.2_Frame_Shift_Ins_p.E66fs|RBM6_uc003cye.2_Frame_Shift_Ins_p.E66fs|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	588					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)														---	---	---	---
RBM5	10181	broad.mit.edu	37	3	50138145	50138145	+	Intron	DEL	A	-	-	rs73835203	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:50138145delA	uc003cyg.2	+						RBM5_uc003cyf.2_3'UTR|RBM5_uc011bdj.1_Intron|RBM5_uc011bdk.1_Intron	NM_005778	NP_005769			RNA binding motif protein 5						apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)														---	---	---	---
DOCK3	1795	broad.mit.edu	37	3	51349786	51349786	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51349786delA	uc011bds.1	+							NM_004947	NP_004938			dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)														---	---	---	---
DNAH1	25981	broad.mit.edu	37	3	52406110	52406110	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52406110delC	uc011bef.1	+							NM_015512	NP_056327			dynein, axonemal, heavy chain 1						ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)														---	---	---	---
TKT	7086	broad.mit.edu	37	3	53269248	53269248	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53269248delC	uc003dgo.2	-						TKT_uc011beo.1_Intron|TKT_uc003dgq.2_Intron|TKT_uc011beq.1_Intron|TKT_uc011ber.1_Intron|TKT_uc011bep.1_Intron	NM_001135055	NP_001128527			transketolase isoform 1						energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			ovary(2)	2		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)													---	---	---	---
CCDC66	285331	broad.mit.edu	37	3	56653283	56653283	+	Intron	DEL	T	-	-	rs113282062		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56653283delT	uc003dhz.2	+						CCDC66_uc003dhy.2_Intron|CCDC66_uc003dhu.2_Intron|CCDC66_uc003dhx.2_Intron|CCDC66_uc003dia.2_Intron	NM_001141947	NP_001135419			coiled-coil domain containing 66 isoform 1											breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)														---	---	---	---
IL17RD	54756	broad.mit.edu	37	3	57137199	57137199	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57137199delT	uc003dil.2	-						IL17RD_uc003dik.2_Intron|IL17RD_uc010hna.2_Intron|IL17RD_uc011bex.1_Intron	NM_017563	NP_060033			interleukin 17 receptor D precursor							Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)														---	---	---	---
APPL1	26060	broad.mit.edu	37	3	57303851	57303851	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:57303851delA	uc003dio.2	+	22					ASB14_uc003dip.1_Intron|ASB14_uc003diq.2_Intron	NM_012096	NP_036228			adaptor protein, phosphotyrosine interaction, PH						apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)														---	---	---	---
C3orf67	200844	broad.mit.edu	37	3	58852557	58852557	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:58852557delT	uc003dkt.1	-						C3orf67_uc003dks.1_Intron|uc003dku.1_Intron|C3orf67_uc003dkv.1_Intron|C3orf67_uc003dkw.2_Intron	NM_198463	NP_940865			hypothetical protein LOC200844												0		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)														---	---	---	---
PTPRG	5793	broad.mit.edu	37	3	62278688	62278688	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:62278688delT	uc003dlb.2	+						PTPRG_uc003dlc.2_Intron|PTPRG_uc011bfi.1_Intron|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832			protein tyrosine phosphatase, receptor type, G						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)														---	---	---	---
ATXN7	6314	broad.mit.edu	37	3	63974140	63974141	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63974140_63974141delAA	uc003dlw.3	+						ATXN7_uc003dlv.2_Intron|ATXN7_uc010hnv.2_Intron|ATXN7_uc011bfn.1_Intron	NM_000333	NP_000324			ataxin 7 isoform a						cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)														---	---	---	---
ADAMTS9	56999	broad.mit.edu	37	3	64590024	64590024	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:64590024delA	uc003dmg.2	-						ADAMTS9_uc011bfo.1_Intron|ADAMTS9_uc003dmh.1_Intron|ADAMTS9_uc011bfp.1_Intron	NM_182920	NP_891550			ADAM metallopeptidase with thrombospondin type 1						glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)														---	---	---	---
MAGI1	9223	broad.mit.edu	37	3	65433764	65433764	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:65433764delA	uc003dmn.2	-						MAGI1_uc003dmm.2_Intron|MAGI1_uc003dmo.2_Intron|MAGI1_uc003dmp.2_Intron|MAGI1_uc010hny.2_Intron	NM_001033057	NP_001028229			membrane associated guanylate kinase, WW and PDZ						cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)														---	---	---	---
MITF	4286	broad.mit.edu	37	3	69915550	69915550	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:69915550delT	uc003dnz.2	+						MITF_uc011bgb.1_Intron|MITF_uc003doa.2_Intron|MITF_uc003dob.2_Intron	NM_198159	NP_937802			microphthalmia-associated transcription factor						melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			ovary(2)	2		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)				A		melanoma 		Waardenburg syndrome type 2|Tietz syndrome						---	---	---	---
SHQ1	55164	broad.mit.edu	37	3	72841936	72841947	+	Intron	DEL	AAAAAAAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:72841936_72841947delAAAAAAAAAAAA	uc003dpf.2	-						SHQ1_uc010hod.2_Intron	NM_018130	NP_060600			SHQ1 homolog						ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)														---	---	---	---
CNTN3	5067	broad.mit.edu	37	3	74548702	74548702	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:74548702delT	uc003dpm.1	-							NM_020872	NP_065923			contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78767037	78767037	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78767037delA	uc003dqe.2	-						ROBO1_uc003dqb.2_Intron|ROBO1_uc003dqc.2_Intron|ROBO1_uc003dqd.2_Intron|ROBO1_uc003dqf.1_5'Flank	NM_002941	NP_002932			roundabout 1 isoform a						activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
EPHA3	2042	broad.mit.edu	37	3	89448447	89448447	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:89448447delT	uc003dqy.2	+						EPHA3_uc003dqx.1_Intron|EPHA3_uc010hon.1_Intron	NM_005233	NP_005224			ephrin receptor EphA3 isoform a precursor							extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)											TSP Lung(6;0.00050)			---	---	---	---
Unknown	0	broad.mit.edu	37	3	90257623	90257623	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:90257623delT								EPHA3 (726341 upstream) : None (None downstream)																																			---	---	---	---
EPHA6	285220	broad.mit.edu	37	3	96706104	96706104	+	Intron	DEL	T	-	-	rs79572640	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:96706104delT	uc010how.1	+						EPHA6_uc003drp.1_Intron	NM_001080448	NP_001073917			EPH receptor A6 isoform a							integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16																		---	---	---	---
EPHA6	285220	broad.mit.edu	37	3	97251435	97251435	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97251435delT	uc010how.1	+						EPHA6_uc011bgo.1_Intron|EPHA6_uc011bgp.1_Intron|EPHA6_uc003drs.3_Intron|EPHA6_uc003drr.3_Intron|EPHA6_uc003drt.2_Intron|EPHA6_uc010hox.1_Intron	NM_001080448	NP_001073917			EPH receptor A6 isoform a							integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16																		---	---	---	---
DCBLD2	131566	broad.mit.edu	37	3	98529907	98529907	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:98529907delT	uc003dtd.2	-						DCBLD2_uc003dte.2_Intron	NM_080927	NP_563615			discoidin, CUB and LCCL domain containing 2						cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
DCBLD2	131566	broad.mit.edu	37	3	98600738	98600740	+	Intron	DEL	TTA	-	-	rs114640102	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:98600738_98600740delTTA	uc003dtd.2	-						DCBLD2_uc003dte.2_Intron|DCBLD2_uc003dtf.1_Intron	NM_080927	NP_563615			discoidin, CUB and LCCL domain containing 2						cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3																		---	---	---	---
C3orf26	84319	broad.mit.edu	37	3	99897121	99897121	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:99897121delT	uc003dtl.2	+							NM_032359	NP_115735			hypothetical protein LOC84319								ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1																		---	---	---	---
TOMM70A	9868	broad.mit.edu	37	3	100096536	100096536	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:100096536delT	uc003dtw.2	-							NM_014820	NP_055635			translocase of outer mitochondrial membrane 70						protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1																		---	---	---	---
ALCAM	214	broad.mit.edu	37	3	105253411	105253412	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:105253411_105253412insA	uc003dvx.2	+						ALCAM_uc003dvw.1_Intron|ALCAM_uc003dvy.2_Intron|ALCAM_uc011bhh.1_Intron|ALCAM_uc010hpp.2_Intron	NM_001627	NP_001618			activated leukocyte cell adhesion molecule						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3																		---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108110522	108110522	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108110522delG	uc003dxa.1	-							NM_014981	NP_055796			myosin, heavy polypeptide 15							myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
MYH15	22989	broad.mit.edu	37	3	108147787	108147787	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108147787delT	uc003dxa.1	-							NM_014981	NP_055796			myosin, heavy polypeptide 15							myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7																		---	---	---	---
KIAA1524	57650	broad.mit.edu	37	3	108300479	108300479	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108300479delA	uc003dxb.3	-						KIAA1524_uc003dxc.1_Intron|KIAA1524_uc010hpw.1_Intron	NM_020890	NP_065941			p90 autoantigen							cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
DZIP3	9666	broad.mit.edu	37	3	108347822	108347822	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108347822delA	uc003dxd.2	+						DZIP3_uc003dxf.1_Intron|DZIP3_uc011bhm.1_Intron|DZIP3_uc003dxe.1_Intron	NM_014648	NP_055463			DAZ interacting protein 3, zinc finger						protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
TRAT1	50852	broad.mit.edu	37	3	108541651	108541651	+	5'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108541651delT	uc003dxi.1	+	1					TRAT1_uc010hpx.1_5'UTR	NM_016388	NP_057472			T-cell receptor interacting molecule						cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1																		---	---	---	---
TRAT1	50852	broad.mit.edu	37	3	108572928	108572928	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108572928delA	uc003dxi.1	+	6					TRAT1_uc010hpx.1_3'UTR	NM_016388	NP_057472			T-cell receptor interacting molecule						cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1																		---	---	---	---
MORC1	27136	broad.mit.edu	37	3	108813922	108813922	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:108813922delA	uc003dxl.2	-						MORC1_uc011bhn.1_Intron	NM_014429	NP_055244			MORC family CW-type zinc finger 1						cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8																		---	---	---	---
DPPA4	55211	broad.mit.edu	37	3	109050952	109050952	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:109050952delT	uc003dxq.3	-						DPPA4_uc011bho.1_Intron|DPPA4_uc011bhp.1_Intron	NM_018189	NP_060659			developmental pluripotency associated 4							nucleus	protein binding			upper_aerodigestive_tract(1)	1																		---	---	---	---
TMPRSS7	344805	broad.mit.edu	37	3	111766545	111766545	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111766545delA	uc010hqb.2	+						TMPRSS7_uc011bhr.1_Intron	NM_001042575	NP_001036040			transmembrane protease, serine 7						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2																		---	---	---	---
TMPRSS7	344805	broad.mit.edu	37	3	111794490	111794490	+	Intron	DEL	T	-	-	rs112959291		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:111794490delT	uc010hqb.2	+						TMPRSS7_uc011bhr.1_Intron	NM_001042575	NP_001036040			transmembrane protease, serine 7						proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	3	112244016	112244016	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112244016delT								BTLA (25608 upstream) : ATG3 (7344 downstream)																																			---	---	---	---
CCDC80	151887	broad.mit.edu	37	3	112357095	112357095	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112357095delT	uc003dzf.2	-	2	1876	c.1658delA	c.(1657-1659)AAGfs	p.K553fs	CCDC80_uc011bhv.1_Frame_Shift_Del_p.K553fs|CCDC80_uc003dzg.2_Frame_Shift_Del_p.K553fs|CCDC80_uc003dzh.1_Frame_Shift_Del_p.K553fs	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	553	Lys-rich.									ovary(2)	2																		---	---	---	---
C3orf17	25871	broad.mit.edu	37	3	112732287	112732288	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112732287_112732288delAA	uc003dzr.2	-						GTPBP8_uc011bhy.1_Intron|C3orf17_uc011bhz.1_Intron|C3orf17_uc010hqh.2_Intron|C3orf17_uc003dzt.2_Intron|C3orf17_uc003dzs.2_Intron|C3orf17_uc010hqg.2_Intron|C3orf17_uc011bia.1_Intron|C3orf17_uc003dzu.2_Intron|C3orf17_uc011bib.1_Intron|C3orf17_uc011bic.1_Intron|C3orf17_uc011bid.1_Intron	NM_015412	NP_056227			hypothetical protein LOC25871							integral to membrane					0																		---	---	---	---
WDR52	55779	broad.mit.edu	37	3	113120664	113120664	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113120664delT	uc003eae.1	-							NM_018338	NP_060808			WD repeat domain 52 isoform 2											central_nervous_system(1)	1																		---	---	---	---
CCDC52	152185	broad.mit.edu	37	3	113225531	113225531	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113225531delA	uc003eag.3	-						CCDC52_uc003eaf.3_Intron|CCDC52_uc011bie.1_Intron|CCDC52_uc003eai.1_Intron	NM_144718	NP_653319			coiled-coil domain containing 52						cell division|mitosis	centriole|spindle	protein binding				0																		---	---	---	---
GRAMD1C	54762	broad.mit.edu	37	3	113656853	113656859	+	Intron	DEL	AAAAAAA	-	-	rs72365441		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113656853_113656859delAAAAAAA	uc003eaq.3	+						GRAMD1C_uc011bil.1_Intron|GRAMD1C_uc003ear.2_Intron|GRAMD1C_uc003eas.2_Intron|GRAMD1C_uc003eat.2_Intron	NM_017577	NP_060047			GRAM domain containing 1C							integral to membrane				ovary(2)|skin(1)	3																		---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114058003delG	uc003ebi.2	-	5	2255	c.2075delC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
IGSF11	152404	broad.mit.edu	37	3	118823867	118823867	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118823867delT	uc003eby.2	-						IGSF11_uc003ebz.2_Intron|IGSF11_uc010hqs.2_Intron	NM_152538	NP_689751			immunoglobulin superfamily, member 11 isoform a						cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0																		---	---	---	---
B4GALT4	8702	broad.mit.edu	37	3	118948948	118948948	+	5'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118948948delT	uc003ecg.2	-	3					B4GALT4_uc003ece.1_5'UTR|B4GALT4_uc003ecf.2_RNA|B4GALT4_uc003ech.2_5'UTR|B4GALT4_uc003eci.2_5'UTR|B4GALT4_uc011biy.1_Intron	NM_212543	NP_997708			UDP-Gal:betaGlcNAc beta 1,4-						membrane lipid metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding|N-acetyllactosamine synthase activity				0				GBM - Glioblastoma multiforme(114;0.222)	N-Acetyl-D-glucosamine(DB00141)													---	---	---	---
STXBP5L	9515	broad.mit.edu	37	3	120924893	120924893	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:120924893delA	uc003eec.3	+						STXBP5L_uc011bji.1_Intron	NM_014980	NP_055795			syntaxin binding protein 5-like						exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)														---	---	---	---
POLQ	10721	broad.mit.edu	37	3	121213811	121213813	+	Intron	DEL	AAA	-	-	rs150851222		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121213811_121213813delAAA	uc003eee.3	-							NM_199420	NP_955452			DNA polymerase theta						DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
HCLS1	3059	broad.mit.edu	37	3	121377299	121377299	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121377299delT	uc003eeh.3	-						HCLS1_uc011bjj.1_Intron|HCLS1_uc011bjk.1_Intron|HCLS1_uc011bjl.1_Intron	NM_005335	NP_005326			hematopoietic cell-specific Lyn substrate 1						erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)														---	---	---	---
IQCB1	9657	broad.mit.edu	37	3	121518237	121518237	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:121518237delA	uc010hre.1	-						IQCB1_uc003eek.2_Intron|IQCB1_uc010hrf.1_Intron	NM_001023570	NP_001018864			IQ motif containing B1 isoform a						cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)														---	---	---	---
PARP14	54625	broad.mit.edu	37	3	122433232	122433232	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122433232delA	uc003efq.3	+	12	4015	c.3956delA	c.(3955-3957)GAAfs	p.E1319fs	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Frame_Shift_Del_p.E1036fs|PARP14_uc003efs.1_Frame_Shift_Del_p.E1036fs	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1319	Macro 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)														---	---	---	---
PDIA5	10954	broad.mit.edu	37	3	122825581	122825581	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122825581delT	uc003egc.1	+						PDIA5_uc003egd.1_Intron	NM_006810	NP_006801			protein disulfide isomerase A5 precursor						cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)														---	---	---	---
SEC22A	26984	broad.mit.edu	37	3	122964979	122964979	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:122964979delT	uc003ege.2	+						SEC22A_uc003egf.2_Intron	NM_012430	NP_036562			SEC22 vesicle trafficking protein homolog A						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0548)														---	---	---	---
KALRN	8997	broad.mit.edu	37	3	124174076	124174076	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124174076delA	uc003ehg.2	+	22	3726	c.3599delA	c.(3598-3600)GAAfs	p.E1200fs	KALRN_uc010hrv.1_Frame_Shift_Del_p.E1191fs|KALRN_uc003ehf.1_Frame_Shift_Del_p.E1200fs|KALRN_uc011bjy.1_Frame_Shift_Del_p.E1191fs|KALRN_uc003ehh.1_Frame_Shift_Del_p.E546fs	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1200	Spectrin 5.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
KALRN	8997	broad.mit.edu	37	3	124175366	124175366	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124175366delT	uc003ehg.2	+						KALRN_uc010hrv.1_Intron|KALRN_uc003ehf.1_Intron|KALRN_uc011bjy.1_Intron|KALRN_uc003ehh.1_Intron	NM_001024660	NP_001019831			kalirin, RhoGEF kinase isoform 1						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
UMPS	7372	broad.mit.edu	37	3	124457070	124457071	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124457070_124457071insA	uc003ehl.3	+	3	1072_1073	c.966_967insA	c.(964-969)GTGAAAfs	p.V322fs	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Frame_Shift_Ins_p.V144fs|UMPS_uc011bkb.1_Frame_Shift_Ins_p.V230fs|UMPS_uc011bkc.1_Frame_Shift_Ins_p.V144fs|UMPS_uc003ehn.3_Frame_Shift_Ins_p.V144fs|UMPS_uc011bkd.1_Frame_Shift_Ins_p.V144fs	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	322_323	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)														---	---	---	---
SLC12A8	84561	broad.mit.edu	37	3	124829013	124829013	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:124829013delA	uc003ehv.3	-						SLC12A8_uc003ehw.3_Intron|SLC12A8_uc003eht.3_Intron|SLC12A8_uc003ehu.3_Intron|SLC12A8_uc010hry.2_Intron	NM_024628	NP_078904			solute carrier family 12, member 8						potassium ion transport	integral to membrane	symporter activity				0																		---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126741193	126741193	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126741193delG	uc003ejg.2	+							NM_032242	NP_115618			plexin A1						axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
MGLL	11343	broad.mit.edu	37	3	127500501	127500502	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:127500501_127500502insT	uc003ejx.2	-						MGLL_uc003ejw.2_Intron|MGLL_uc011bko.1_Intron|MGLL_uc010hsp.1_Intron	NM_001003794	NP_001003794			monoglyceride lipase isoform 2						arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity				0																		---	---	---	---
RAB7A	7879	broad.mit.edu	37	3	128516847	128516848	+	Frame_Shift_Ins	INS	-	CC	CC			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128516847_128516848insCC	uc003eks.1	+	3	347_348	c.115_116insCC	c.(115-117)GCCfs	p.A39fs	RAB7A_uc010hsv.1_Frame_Shift_Ins_p.A39fs|RAB7A_uc003ekt.2_Frame_Shift_Ins_p.A15fs	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	39	Effector region (By similarity).				endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)														---	---	---	---
MBD4	8930	broad.mit.edu	37	3	129152182	129152182	+	Intron	DEL	T	-	-	rs72112332		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129152182delT	uc003emh.1	-						MBD4_uc003emi.1_Intron|MBD4_uc003emj.1_Intron|MBD4_uc003emk.1_Intron|MBD4_uc011bkw.1_Intron	NM_003925	NP_003916			methyl-CpG binding domain protein 4						depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			ovary(1)|lung(1)	2													BER_DNA_glycosylases					---	---	---	---
RHO	6010	broad.mit.edu	37	3	129252686	129252687	+	3'UTR	DEL	TT	-	-	rs71811187		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:129252686_129252687delTT	uc003emt.2	+	5						NM_000539	NP_000530			rhodopsin						protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)													---	---	---	---
Unknown	0	broad.mit.edu	37	3	130547277	130547277	+	IGR	DEL	A	-	-	rs3211035		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130547277delA								PIK3R4 (81581 upstream) : ATP2C1 (22168 downstream)																																			---	---	---	---
NEK11	79858	broad.mit.edu	37	3	130871047	130871047	+	Intron	DEL	T	-	-	rs150507740	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130871047delT	uc003eny.2	+						NEK11_uc003enx.2_Intron|NEK11_uc003eoa.2_Intron|NEK11_uc003enz.2_Intron|NEK11_uc010htn.2_Intron|NEK11_uc011blk.1_Intron|NEK11_uc011bll.1_Intron|NEK11_uc011blm.1_Intron|NEK11_uc010hto.1_Intron	NM_024800	NP_079076			NIMA-related kinase 11 isoform 1						cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6																		---	---	---	---
TOPBP1	11073	broad.mit.edu	37	3	133342879	133342879	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133342879delA	uc003eps.2	-						TOPBP1_uc003ept.1_Intron	NM_007027	NP_008958			topoisomerase (DNA) II binding protein 1						DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7													Other_conserved_DNA_damage_response_genes					---	---	---	---
SRPRB	58477	broad.mit.edu	37	3	133538694	133538694	+	3'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:133538694delG	uc003epx.1	+	7						NM_021203	NP_067026			signal recognition particle receptor, beta							endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1																		---	---	---	---
ARMC8	25852	broad.mit.edu	37	3	137963915	137963915	+	Intron	DEL	T	-	-	rs76013931		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:137963915delT	uc003esa.1	+						ARMC8_uc003erw.2_Intron|ARMC8_uc003erx.2_Intron|ARMC8_uc003ery.2_Intron|ARMC8_uc003erz.2_Intron|ARMC8_uc011bmf.1_Intron|ARMC8_uc011bmg.1_Intron|ARMC8_uc011bmh.1_Intron|ARMC8_uc003esb.1_Intron|ARMC8_uc003esc.1_Intron	NM_015396	NP_056211			armadillo repeat containing 8 isoform 2								binding				0																		---	---	---	---
ARMC8	25852	broad.mit.edu	37	3	138007827	138007827	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138007827delA	uc003esa.1	+						TXNDC6_uc003esd.1_Intron|TXNDC6_uc010huf.1_Intron|TXNDC6_uc003ese.1_Intron|ARMC8_uc011bmf.1_Intron|ARMC8_uc011bmg.1_Intron|ARMC8_uc011bmh.1_Intron|ARMC8_uc003esb.1_Intron|ARMC8_uc003esc.1_Intron|ARMC8_uc003esf.1_Intron	NM_015396	NP_056211			armadillo repeat containing 8 isoform 2								binding				0																		---	---	---	---
CEP70	80321	broad.mit.edu	37	3	138227398	138227398	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:138227398delA	uc003esl.2	-						CEP70_uc011bmk.1_Intron|CEP70_uc011bml.1_Intron|CEP70_uc011bmm.1_Intron|CEP70_uc003esm.2_Intron	NM_024491	NP_077817			centrosomal protein 70 kDa						G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1																		---	---	---	---
SLC25A36	55186	broad.mit.edu	37	3	140675627	140675627	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140675627delT	uc003etr.2	+						SLC25A36_uc003etp.2_Intron|SLC25A36_uc003ets.2_Intron|SLC25A36_uc003etq.2_Intron|SLC25A36_uc011bmz.1_Intron	NM_001104647	NP_001098117			solute carrier family 25, member 36 isoform a						response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
ATR	545	broad.mit.edu	37	3	142279407	142279408	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142279407_142279408delTT	uc003eux.3	-							NM_001184	NP_001175			ataxia telangiectasia and Rad3 related protein						cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20													Other_conserved_DNA_damage_response_genes					---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142383213	142383213	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142383213delA	uc010huv.2	+						PLS1_uc003euz.2_Intron|PLS1_uc003eva.2_Intron	NM_001145319	NP_001138791			plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
PLS1	5357	broad.mit.edu	37	3	142423444	142423444	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142423444delA	uc010huv.2	+						PLS1_uc003euz.2_Intron|PLS1_uc003eva.2_Intron	NM_001145319	NP_001138791			plastin 1							cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1																		---	---	---	---
SLC9A9	285195	broad.mit.edu	37	3	142987575	142987584	+	Intron	DEL	AAAAAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142987575_142987584delAAAAAAAAAA	uc003evn.2	-							NM_173653	NP_775924			solute carrier family 9 (sodium/hydrogen						regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3																		---	---	---	---
PLOD2	5352	broad.mit.edu	37	3	145820681	145820682	+	Intron	INS	-	GT	GT			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:145820681_145820682insGT	uc003evs.1	-						PLOD2_uc011bnm.1_Intron|PLOD2_uc003evr.1_Intron	NM_000935	NP_000926			procollagen-lysine, 2-oxoglutarate 5-dioxygenase						protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)													---	---	---	---
CPB1	1360	broad.mit.edu	37	3	148562685	148562686	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148562685_148562686delAA	uc003ewl.2	+							NM_001871	NP_001862			pancreatic carboxypeptidase B1 preproprotein						proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)															---	---	---	---
CPB1	1360	broad.mit.edu	37	3	148563475	148563475	+	Intron	DEL	A	-	-	rs139558909		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148563475delA	uc003ewl.2	+							NM_001871	NP_001862			pancreatic carboxypeptidase B1 preproprotein						proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)															---	---	---	---
FAM194A	131831	broad.mit.edu	37	3	150403431	150403433	+	Intron	DEL	TTC	-	-	rs138634429	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150403431_150403433delTTC	uc003eyg.2	-						FAM194A_uc003eyh.2_Intron	NM_152394	NP_689607			hypothetical protein LOC131831											skin(2)|ovary(1)	3																		---	---	---	---
SGEF	26084	broad.mit.edu	37	3	153905449	153905449	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:153905449delT	uc011bog.1	+						SGEF_uc011boh.1_Intron	NM_015595	NP_056410			Src homology 3 domain-containing guanine						regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)															---	---	---	---
C3orf33	285315	broad.mit.edu	37	3	155481462	155481463	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155481462_155481463insA	uc003fal.1	-	6	869_870	c.599_600insT	c.(598-600)TTAfs	p.L200fs	C3orf33_uc003fam.1_Frame_Shift_Ins_p.L243fs	NM_173657	NP_775928	Q96NB5	Q96NB5_HUMAN	hypothetical protein LOC285315	200							hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
C3orf33	285315	broad.mit.edu	37	3	155493410	155493410	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155493410delT	uc003fal.1	-						C3orf33_uc003fam.1_Intron	NM_173657	NP_775928			hypothetical protein LOC285315								hydrolase activity, acting on ester bonds|nucleic acid binding				0			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)															---	---	---	---
GMPS	8833	broad.mit.edu	37	3	155628358	155628366	+	Intron	DEL	AAAAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:155628358_155628366delAAAAAAAAA	uc003faq.2	+						GMPS_uc011bom.1_Intron	NM_003875	NP_003866			guanine monophosphate synthetase						glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)			T	MLL	AML								---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167218123	167218123	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167218123delA	uc003fev.1	-						WDR49_uc003feu.1_Intron|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146			WD repeat domain 49											large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
MECOM	2122	broad.mit.edu	37	3	168833604	168833605	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:168833604_168833605insT	uc003ffi.3	-	7	1760_1761	c.1491_1492insA	c.(1489-1494)AAAGTTfs	p.K497fs	MECOM_uc010hwk.1_Frame_Shift_Ins_p.K520fs|MECOM_uc003ffj.3_Frame_Shift_Ins_p.K562fs|MECOM_uc011bpi.1_Frame_Shift_Ins_p.K498fs|MECOM_uc003ffn.3_Frame_Shift_Ins_p.K497fs|MECOM_uc003ffk.2_Frame_Shift_Ins_p.K497fs|MECOM_uc003ffl.2_Frame_Shift_Ins_p.K657fs|MECOM_uc011bpj.1_Frame_Shift_Ins_p.K685fs|MECOM_uc011bpk.1_Frame_Shift_Ins_p.K487fs|MECOM_uc010hwn.2_Frame_Shift_Ins_p.K685fs	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	497_498					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14																		---	---	---	---
MYNN	55892	broad.mit.edu	37	3	169501506	169501506	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169501506delT	uc003fft.2	+						MYNN_uc011bpm.1_Intron|MYNN_uc003ffu.2_Intron|MYNN_uc003ffv.2_Intron|MYNN_uc010hwo.2_Intron|MYNN_uc003ffw.1_Intron	NM_018657	NP_061127			myoneurin							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;2.19e-58)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)															---	---	---	---
PRKCI	5584	broad.mit.edu	37	3	169998127	169998128	+	Frame_Shift_Ins	INS	-	A	A	rs150239950		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:169998127_169998128insA	uc003fgs.2	+	9	1056_1057	c.818_819insA	c.(817-819)TTAfs	p.L273fs		NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	273	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)															---	---	---	---
EIF5A2	56648	broad.mit.edu	37	3	170624844	170624844	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170624844delT	uc003fhd.2	-	3	334	c.204delA	c.(202-204)AAAfs	p.K68fs		NM_020390	NP_065123	Q9GZV4	IF5A2_HUMAN	eIF-5A2 protein	68					mRNA transport|peptidyl-lysine modification to hypusine|polyamine homeostasis|positive regulation of cell proliferation|positive regulation of translational elongation|positive regulation of translational termination|post-translational protein modification|protein transport|spermatogenesis|translational frameshifting|transmembrane transport	cytosol|endoplasmic reticulum membrane|nuclear pore	protein binding|ribosome binding|translation elongation factor activity				0	all_cancers(22;1.61e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;9.8e-16)|Lung(28;4.28e-15)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	172546962	172546962	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172546962delT								ECT2 (7699 upstream) : SPATA16 (60186 downstream)																																			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178917413	178917413	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178917413delA	uc003fjk.2	+							NM_006218	NP_006209			phosphoinositide-3-kinase, catalytic, alpha						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178951767	178951767	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178951767delT	uc003fjk.2	+							NM_006218	NP_006209			phosphoinositide-3-kinase, catalytic, alpha						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PEX5L	51555	broad.mit.edu	37	3	179592014	179592014	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:179592014delA	uc003fki.1	-						PEX5L_uc011bqd.1_Intron|PEX5L_uc011bqe.1_Intron|PEX5L_uc011bqf.1_Intron|PEX5L_uc003fkj.1_Intron|PEX5L_uc010hxd.1_Intron|PEX5L_uc011bqg.1_Intron|PEX5L_uc011bqh.1_Intron	NM_016559	NP_057643			peroxisomal biogenesis factor 5-like						protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)															---	---	---	---
TTC14	151613	broad.mit.edu	37	3	180322630	180322630	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180322630delT	uc003fkk.2	+						TTC14_uc003fkl.2_Intron|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719			tetratricopeptide repeat domain 14 isoform a								RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
CCDC39	339829	broad.mit.edu	37	3	180365067	180365067	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180365067delA	uc010hxe.2	-						CCDC39_uc003fkn.2_Intron	NM_181426	NP_852091			coiled-coil domain containing 39						axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)															---	---	---	---
FXR1	8087	broad.mit.edu	37	3	180680889	180680894	+	Intron	DEL	ATTTTT	-	-	rs75138233		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:180680889_180680894delATTTTT	uc003fkq.2	+						FXR1_uc003fkp.2_Intron|FXR1_uc003fkr.2_Intron|FXR1_uc011bqj.1_Intron|FXR1_uc003fks.2_Intron|FXR1_uc011bqk.1_Intron|FXR1_uc011bql.1_Intron	NM_005087	NP_005078			fragile X mental retardation-related protein 1						apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)															---	---	---	---
ABCC5	10057	broad.mit.edu	37	3	183665257	183665257	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183665257delA	uc003fmg.2	-	23	3434	c.3269delT	c.(3268-3270)TTGfs	p.L1090fs	ABCC5_uc011bqt.1_Frame_Shift_Del_p.L618fs|ABCC5_uc010hxl.2_Frame_Shift_Del_p.L1047fs	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1090	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)															---	---	---	---
HTR3E	285242	broad.mit.edu	37	3	183821908	183821908	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:183821908delT	uc010hxq.2	+						HTR3E_uc003fml.3_Intron|HTR3E_uc003fmm.2_Intron|HTR3E_uc010hxr.2_Intron|HTR3E_uc003fmn.2_Intron	NM_182589	NP_872395			5-hydroxytryptamine receptor 3 subunit E							integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)															---	---	---	---
EIF4G1	1981	broad.mit.edu	37	3	184046178	184046178	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184046178delA	uc003fnp.2	+						EIF4G1_uc003fnt.2_Intron|EIF4G1_uc003fnq.2_Intron|EIF4G1_uc003fnr.2_Intron|EIF4G1_uc010hxx.2_Intron|EIF4G1_uc003fns.2_Intron|EIF4G1_uc010hxy.2_Intron|EIF4G1_uc003fnv.3_Intron|EIF4G1_uc003fnu.3_Intron|EIF4G1_uc003fnw.2_Intron|EIF4G1_uc003fnx.2_Intron|EIF4G1_uc003fny.3_Intron|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884			eukaryotic translation initiation factor 4						insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)															---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184567676	184567676	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184567676delA	uc003fpb.1	+						VPS8_uc010hyd.1_Intron	NM_015303	NP_056118			vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
VPS8	23355	broad.mit.edu	37	3	184742112	184742112	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184742112delT	uc003fpb.1	+						VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Intron	NM_015303	NP_056118			vacuolar protein sorting 8 homolog isoform b								zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)															---	---	---	---
LIPH	200879	broad.mit.edu	37	3	185229608	185229611	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:185229608_185229611delTTTT	uc003fpm.2	-						LIPH_uc010hyh.2_Intron	NM_139248	NP_640341			lipase, member H precursor						lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)															---	---	---	---
Unknown	0	broad.mit.edu	37	3	190550005	190550005	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:190550005delA								IL1RAP (174162 upstream) : LOC647309 (20521 downstream)																																			---	---	---	---
OPA1	4976	broad.mit.edu	37	3	193361987	193361987	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:193361987delA	uc003ftm.2	+						OPA1_uc003ftg.2_Intron|OPA1_uc003fth.2_Intron|OPA1_uc003fti.2_Intron|OPA1_uc003ftj.2_Intron|OPA1_uc003ftk.2_Intron|OPA1_uc003ftl.2_Intron|OPA1_uc003ftn.2_Intron	NM_015560	NP_056375			optic atrophy 1 isoform 1						apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)														---	---	---	---
MUC4	4585	broad.mit.edu	37	3	195492335	195492335	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195492335delG	uc011bto.1	-						MUC4_uc003fuz.2_Intron|MUC4_uc003fva.2_Intron|MUC4_uc003fvb.2_Intron|MUC4_uc003fvc.2_Intron|MUC4_uc003fvd.2_Intron|MUC4_uc003fve.2_Intron|MUC4_uc010hzr.2_Intron|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876			mucin 4 isoform a						cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)														---	---	---	---
SDHAP1	255812	broad.mit.edu	37	3	195709193	195709193	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195709193delA	uc011btq.1	-						SDHAP1_uc003fvx.3_Intron|SDHAP1_uc011btp.1_Intron					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0																		---	---	---	---
PCYT1A	5130	broad.mit.edu	37	3	195975231	195975231	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:195975231delT	uc003fwg.2	-						PCYT1A_uc003fwh.2_Intron	NM_005017	NP_005008			choline phosphate cytidylyltransferase 1 alpha							cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)													---	---	---	---
NCBP2	22916	broad.mit.edu	37	3	196664216	196664216	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196664216delA	uc003fxd.1	-						NCBP2_uc003fxb.1_Intron|NCBP2_uc011btz.1_Intron|NCBP2_uc003fxc.1_Intron|NCBP2_uc003fxe.1_Intron|NCBP2_uc003fxf.2_3'UTR	NM_007362	NP_031388			nuclear cap binding protein subunit 2, 20kDa						gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of RNA export from nucleus|positive regulation of viral transcription|regulation of translational initiation|snRNA export from nucleus|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm	nucleotide binding|protein binding|RNA 7-methylguanosine cap binding				0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.42e-24)|all cancers(36;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(49;4.13e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00551)														---	---	---	---
DLG1	1739	broad.mit.edu	37	3	196842721	196842721	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196842721delA	uc003fxo.3	-						DLG1_uc011bub.1_Intron|DLG1_uc011buc.1_Intron|DLG1_uc011bud.1_Intron|DLG1_uc003fxn.3_Intron|DLG1_uc011bue.1_Intron|DLG1_uc010ial.2_Intron|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_Intron|DLG1_uc010iam.1_Intron	NM_001098424	NP_001091894			discs, large homolog 1 isoform 1						actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
KIAA0226	9711	broad.mit.edu	37	3	197427748	197427748	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197427748delG	uc003fyc.2	-	7	1180	c.997delC	c.(997-999)CGAfs	p.R333fs	KIAA0226_uc003fyd.3_Frame_Shift_Del_p.R273fs|KIAA0226_uc003fye.1_Frame_Shift_Del_p.R40fs|KIAA0226_uc003fyf.2_Frame_Shift_Del_p.R166fs|KIAA0226_uc003fyg.2_Frame_Shift_Del_p.R326fs	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	333	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)														---	---	---	---
PCGF3	10336	broad.mit.edu	37	4	728799	728799	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:728799delC	uc011bva.1	+	6	664	c.189delC	c.(187-189)CACfs	p.H63fs	PCGF3_uc003gbc.1_RNA|PCGF3_uc003gbd.1_RNA|PCGF3_uc003gbe.2_Frame_Shift_Del_p.H63fs|PCGF3_uc010ibh.2_Frame_Shift_Del_p.H63fs|PCGF3_uc003gbg.1_Frame_Shift_Del_p.H29fs|PCGF3_uc003gbh.2_Frame_Shift_Del_p.H29fs	NM_006315	NP_006306	Q3KNV8	PCGF3_HUMAN	ring finger protein 3	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex	zinc ion binding				0																		---	---	---	---
LETM1	3954	broad.mit.edu	37	4	1834801	1834801	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1834801delT	uc003gdv.2	-							NM_012318	NP_036450			leucine zipper-EF-hand containing transmembrane						cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)															---	---	---	---
WHSC1	7468	broad.mit.edu	37	4	1919853	1919853	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1919853delT	uc003gdz.3	+						WHSC1_uc003geb.3_Intron|WHSC1_uc003gec.3_Intron|WHSC1_uc003ged.3_Intron|WHSC1_uc003gee.3_Intron|WHSC1_uc003gef.3_Intron|WHSC1_uc003gdx.2_Intron|WHSC1_uc003gdy.1_Intron|WHSC1_uc010icd.1_Intron|WHSC1_uc003gea.1_Intron|WHSC1_uc010ice.1_Intron|WHSC1_uc003geh.1_Intron	NM_001042424	NP_001035889			Wolf-Hirschhorn syndrome candidate 1 protein						anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)				T	IGH@	MM								---	---	---	---
POLN	353497	broad.mit.edu	37	4	2130784	2130788	+	Intron	DEL	AAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2130784_2130788delAAAAA	uc003ger.2	-						POLN_uc010icg.1_Intron|POLN_uc010ich.1_Intron	NM_181808	NP_861524			DNA-directed DNA polymerase nu						DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
HAUS3	79441	broad.mit.edu	37	4	2242634	2242634	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2242634delT	uc003ges.1	-	2	270	c.40delA	c.(40-42)ATTfs	p.I14fs	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Frame_Shift_Del_p.I14fs|HAUS3_uc003get.1_Frame_Shift_Del_p.I14fs	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	14					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4																		---	---	---	---
NOP14	8602	broad.mit.edu	37	4	2958590	2958590	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2958590delA	uc003ggj.1	-						C4orf10_uc003ggi.1_Intron|NOP14_uc003ggk.3_Intron|NOP14_uc003ggl.2_Intron|NOP14_uc010icq.1_Intron	NM_003703	NP_003694			probable nucleolar complex protein 14						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1																		---	---	---	---
EVC	2121	broad.mit.edu	37	4	5720877	5720878	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5720877_5720878insG	uc003gil.1	+						EVC_uc003gim.1_Intron	NM_153717	NP_714928			Ellis van Creveld syndrome protein						muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
SORCS2	57537	broad.mit.edu	37	4	7726732	7726733	+	Intron	INS	-	TGG	TGG			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7726732_7726733insTGG	uc003gkb.3	+						SORCS2_uc011bwi.1_Intron	NM_020777	NP_065828			VPS10 domain receptor protein SORCS 2 precursor							integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ABLIM2	84448	broad.mit.edu	37	4	8089996	8089996	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:8089996delG	uc003gko.2	-	4	497	c.354delC	c.(352-354)CCCfs	p.P118fs	ABLIM2_uc003gkj.3_Frame_Shift_Del_p.P118fs|ABLIM2_uc003gkm.3_Frame_Shift_Del_p.P118fs|ABLIM2_uc003gkp.2_Frame_Shift_Del_p.P118fs|ABLIM2_uc003gkq.2_Frame_Shift_Del_p.P118fs|ABLIM2_uc003gkr.2_Frame_Shift_Del_p.P118fs|ABLIM2_uc003gks.3_Frame_Shift_Del_p.P118fs|ABLIM2_uc011bwl.1_Frame_Shift_Del_p.P123fs	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	118	LIM zinc-binding 2.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3																		---	---	---	---
WDR1	9948	broad.mit.edu	37	4	10084631	10084631	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10084631delC	uc003gmf.2	-						WDR1_uc003gmg.2_Intron|WDR1_uc010idm.2_Intron	NM_017491	NP_059830			WD repeat-containing protein 1 isoform 1						platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)														---	---	---	---
ZNF518B	85460	broad.mit.edu	37	4	10446552	10446553	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:10446552_10446553insT	uc003gmn.2	-	3	1887_1888	c.1400_1401insA	c.(1399-1401)AATfs	p.N467fs		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4																		---	---	---	---
BOD1L	259282	broad.mit.edu	37	4	13582681	13582681	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:13582681delA	uc003gmz.1	-							NM_148894	NP_683692			biorientation of chromosomes in cell division								DNA binding			ovary(5)|breast(1)	6																		---	---	---	---
CPEB2	132864	broad.mit.edu	37	4	15063620	15063621	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15063620_15063621delTT	uc003gni.1	+						CPEB2_uc003gnj.1_Intron|CPEB2_uc003gnk.1_Intron|CPEB2_uc003gnl.1_Intron|CPEB2_uc003gnm.1_Intron|CPEB2_uc003gnn.1_Intron	NM_182485	NP_872291			cytoplasmic polyadenylation element binding						regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
KCNIP4	80333	broad.mit.edu	37	4	21305413	21305413	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:21305413delA	uc003gqf.1	-						KCNIP4_uc003gqg.1_Intron|KCNIP4_uc003gqh.1_Intron|KCNIP4_uc003gqi.1_Intron	NM_147183	NP_671712			Kv channel interacting protein 4 isoform 4							plasma membrane	calcium ion binding|potassium channel activity|protein binding|voltage-gated ion channel activity				0		Breast(46;0.134)																---	---	---	---
STIM2	57620	broad.mit.edu	37	4	27019137	27019137	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:27019137delT	uc003gsh.3	+						STIM2_uc003gsg.3_Intron|STIM2_uc010iex.2_Intron|STIM2_uc010iey.2_Intron	NM_020860	NP_065911			stromal interaction molecule 2						activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			central_nervous_system(1)|skin(1)	2		Breast(46;0.0503)																---	---	---	---
ARAP2	116984	broad.mit.edu	37	4	36230062	36230062	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:36230062delT	uc003gsq.1	-						ARAP2_uc003gsr.1_Intron	NM_015230	NP_056045			ArfGAP with RhoGAP domain, ankyrin repeat and PH						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
TBC1D1	23216	broad.mit.edu	37	4	38134766	38134768	+	In_Frame_Del	DEL	AAG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38134766_38134768delAAG	uc003gtb.2	+	19	3537_3539	c.3194_3196delAAG	c.(3193-3198)CAAGAA>CAA	p.E1067del	TBC1D1_uc011byd.1_In_Frame_Del_p.E1058del|TBC1D1_uc010ifd.2_In_Frame_Del_p.E854del|TBC1D1_uc003gtd.2_In_Frame_Del_p.E79del	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	1067						nucleus	Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
KLF3	51274	broad.mit.edu	37	4	38690054	38690054	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38690054delT	uc003gth.3	+						KLF3_uc003gtg.2_Intron	NM_016531	NP_057615			Kruppel-like factor 3 (basic)						multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
TLR10	81793	broad.mit.edu	37	4	38777276	38777276	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:38777276delA	uc003gti.2	-						TLR10_uc003gtj.2_Intron|TLR10_uc003gtk.2_Intron	NM_030956	NP_112218			toll-like receptor 10 precursor						inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2																		---	---	---	---
RFC1	5981	broad.mit.edu	37	4	39313233	39313233	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39313233delA	uc003gty.1	-						RFC1_uc003gtx.1_Intron	NM_002913	NP_002904			replication factor C large subunit						DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
PDS5A	23244	broad.mit.edu	37	4	39929853	39929855	+	Intron	DEL	TAA	-	-	rs149442914		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39929853_39929855delTAA	uc003guv.3	-						PDS5A_uc010ifo.2_Intron|PDS5A_uc003guw.3_Intron	NM_001100399	NP_001093869			PDS5, regulator of cohesion maintenance, homolog						cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0																		---	---	---	---
N4BP2	55728	broad.mit.edu	37	4	40121855	40121855	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:40121855delA	uc003guy.3	+	9	2462	c.2124delA	c.(2122-2124)GTAfs	p.V708fs	N4BP2_uc010ifq.2_Frame_Shift_Del_p.V628fs|N4BP2_uc010ifr.2_Frame_Shift_Del_p.V628fs	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	708						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	41844010	41844010	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41844010delT								PHOX2B (93023 upstream) : TMEM33 (93127 downstream)																																			---	---	---	---
ATP8A1	10396	broad.mit.edu	37	4	42466834	42466834	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:42466834delA	uc003gwr.2	-						ATP8A1_uc003gwq.2_Intron|ATP8A1_uc003gws.2_Intron	NM_006095	NP_006086			ATPase, aminophospholipid transporter (APLT),						ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
Unknown	0	broad.mit.edu	37	4	44997139	44997139	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:44997139delT								GNPDA2 (268527 upstream) : None (None downstream)																																			---	---	---	---
NFXL1	152518	broad.mit.edu	37	4	47888020	47888020	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47888020delA	uc010igh.2	-						NFXL1_uc003gxp.2_Intron|NFXL1_uc003gxq.3_Intron|NFXL1_uc010igi.2_Intron	NM_152995	NP_694540			nuclear transcription factor, X-box binding-like							integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
NIPAL1	152519	broad.mit.edu	37	4	48038331	48038331	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48038331delT	uc003gxw.2	+	6						NM_207330	NP_997213			NIPA-like domain containing 1							integral to membrane					0																		---	---	---	---
TEC	7006	broad.mit.edu	37	4	48152855	48152855	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48152855delA	uc003gxz.2	-							NM_003215	NP_003206			tec protein tyrosine kinase						intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9																		---	---	---	---
FRYL	285527	broad.mit.edu	37	4	48625212	48625213	+	Intron	DEL	AC	-	-	rs776579	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48625212_48625213delAC	uc003gyh.1	-						FRYL_uc003gyk.2_Intron|FRYL_uc003gyl.1_Intron|FRYL_uc003gym.1_Intron	NM_015030	NP_055845			furry-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	49558138	49558138	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:49558138delT								CWH43 (494045 upstream) : None (None downstream)																																			---	---	---	---
DCUN1D4	23142	broad.mit.edu	37	4	52752611	52752611	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52752611delT	uc003gze.2	+						DCUN1D4_uc003gzf.2_Intron|DCUN1D4_uc011bzn.1_Intron|DCUN1D4_uc003gzg.2_Intron|DCUN1D4_uc003gzh.2_Intron|DCUN1D4_uc011bzo.1_Intron	NM_001040402	NP_001035492			DCN1, defective in cullin neddylation 1, domain											ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)															---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52926826	52926826	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52926826delT	uc003gzl.2	+						SPATA18_uc010igl.1_Intron|SPATA18_uc011bzq.1_Intron|SPATA18_uc003gzk.1_Intron	NM_145263	NP_660306			spermatogenesis associated 18 homolog						mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
SPATA18	132671	broad.mit.edu	37	4	52951073	52951073	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52951073delT	uc003gzl.2	+						SPATA18_uc010igl.1_Intron|SPATA18_uc011bzq.1_Intron	NM_145263	NP_660306			spermatogenesis associated 18 homolog						mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)															---	---	---	---
PDGFRA	5156	broad.mit.edu	37	4	54348115	54348115	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54348115delT	uc003haa.2	+						LNX1_uc003haf.3_Intron|LNX1_uc003hag.3_Intron|LNX1_uc003hah.3_Intron	NM_006206	NP_006197			platelet-derived growth factor receptor alpha						cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			---	---	---	---
SRP72	6731	broad.mit.edu	37	4	57336008	57336008	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57336008delT	uc003hbv.2	+						SRP72_uc010ihe.2_Intron	NM_006947	NP_008878			signal recognition particle 72kDa						response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)																	---	---	---	---
Unknown	0	broad.mit.edu	37	4	57500223	57500223	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:57500223delA								ARL9 (110165 upstream) : HOPX (13931 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	4	62971329	62971330	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:62971329_62971330insT								LPHN3 (33162 upstream) : None (None downstream)																																			---	---	---	---
YTHDC1	91746	broad.mit.edu	37	4	69199142	69199142	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69199142delA	uc003hdx.2	-						YTHDC1_uc003hdy.2_Intron	NM_001031732	NP_001026902			splicing factor YT521-B isoform 1											upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	4	69444612	69444612	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:69444612delT								YTHDC1 (228788 upstream) : UGT2B15 (67704 downstream)																																			---	---	---	---
UGT2B4	7363	broad.mit.edu	37	4	70360942	70360942	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70360942delT	uc003hek.3	-	1	685	c.638delA	c.(637-639)AATfs	p.N213fs	UGT2B4_uc011cap.1_Frame_Shift_Del_p.N77fs|UGT2B4_uc003hel.3_Frame_Shift_Del_p.N213fs	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	213					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2																		---	---	---	---
SULT1B1	27284	broad.mit.edu	37	4	70592931	70592931	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70592931delA	uc003hen.2	-							NM_014465	NP_055280			sulfotransferase family, cytosolic, 1B, member						3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0																		---	---	---	---
CSN1S1	1446	broad.mit.edu	37	4	70810695	70810695	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70810695delA	uc003hep.1	+	15	579	c.530delA	c.(529-531)GAAfs	p.E177fs	CSN1S1_uc003heq.1_Frame_Shift_Del_p.E168fs|CSN1S1_uc003her.1_Frame_Shift_Del_p.E169fs	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	177						extracellular region	protein binding|transporter activity				0																		---	---	---	---
CSN2	1447	broad.mit.edu	37	4	70825882	70825882	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70825882delA	uc003hes.3	-						CSN2_uc003het.3_Intron	NM_001891	NP_001882			casein beta precursor						calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0																		---	---	---	---
CSN2	1447	broad.mit.edu	37	4	70826811	70826811	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:70826811delA	uc003hes.3	-						CSN2_uc003het.3_5'Flank	NM_001891	NP_001882			casein beta precursor						calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity				0																		---	---	---	---
AMBN	258	broad.mit.edu	37	4	71464057	71464057	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71464057delT	uc003hfl.2	+							NM_016519	NP_057603			ameloblastin precursor						bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)															---	---	---	---
RUFY3	22902	broad.mit.edu	37	4	71668652	71668652	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71668652delT	uc003hfr.2	+						RUFY3_uc011cay.1_Intron	NM_001037442	NP_001032519			RUN and FYVE domain containing 3 isoform 1						negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)															---	---	---	---
DCK	1633	broad.mit.edu	37	4	71892332	71892332	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:71892332delT	uc003hfx.2	+						DCK_uc011cbb.1_Intron	NM_000788	NP_000779			deoxycytidine kinase						purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			ovary(1)	1			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)													---	---	---	---
SLC4A4	8671	broad.mit.edu	37	4	72300086	72300086	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:72300086delA	uc003hfy.2	+						SLC4A4_uc010iic.2_Intron|SLC4A4_uc010iib.2_Intron|SLC4A4_uc003hfz.2_Intron|SLC4A4_uc003hgc.3_Intron|SLC4A4_uc003hga.2_Intron|SLC4A4_uc003hgb.3_Intron	NM_001098484	NP_001091954			solute carrier family 4, sodium bicarbonate							basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)															---	---	---	---
GC	2638	broad.mit.edu	37	4	72629050	72629051	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:72629050_72629051insA	uc003hge.2	-						GC_uc003hgd.2_Intron|GC_uc010iie.2_Intron|GC_uc010iif.2_Intron	NM_000583	NP_000574			vitamin D-binding protein precursor						hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)													---	---	---	---
NUP54	53371	broad.mit.edu	37	4	77045927	77045928	+	Intron	DEL	GG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77045927_77045928delGG	uc003hjs.2	-						NUP54_uc010ije.2_Intron|NUP54_uc011cbs.1_Intron|NUP54_uc011cbt.1_Intron|NUP54_uc003hjt.2_Intron	NM_017426	NP_059122			nucleoporin 54kDa						carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2																		---	---	---	---
SEPT11	55752	broad.mit.edu	37	4	77933163	77933164	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:77933163_77933164delTT	uc003hkj.2	+						SEPT11_uc010ijh.1_Intron|SEPT11_uc011cca.1_Intron|SEPT11_uc003hkk.1_5'Flank	NM_018243	NP_060713			septin 11						cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0																		---	---	---	---
MRPL1	65008	broad.mit.edu	37	4	78793017	78793017	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:78793017delT	uc003hku.2	+							NM_020236	NP_064621			mitochondrial ribosomal protein L1 precursor								RNA binding				0																		---	---	---	---
MRPL1	65008	broad.mit.edu	37	4	78806529	78806529	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:78806529delT	uc003hku.2	+						MRPL1_uc010iji.1_Intron	NM_020236	NP_064621			mitochondrial ribosomal protein L1 precursor								RNA binding				0																		---	---	---	---
ANTXR2	118429	broad.mit.edu	37	4	80906023	80906023	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:80906023delA	uc003hlz.3	-						ANTXR2_uc003hly.3_Intron|ANTXR2_uc003hlx.1_Intron|ANTXR2_uc010ijn.2_Intron	NM_001145794	NP_001139266			anthrax toxin receptor 2 isoform 2							endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1														Juvenile_Hyaline_Fibromatosis				---	---	---	---
C4orf22	255119	broad.mit.edu	37	4	81256796	81256796	+	5'Flank	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81256796delG	uc003hmf.2	+						C4orf22_uc010ijp.2_5'Flank	NM_152770	NP_689983			hypothetical protein LOC255119											skin(2)	2																		---	---	---	---
RASGEF1B	153020	broad.mit.edu	37	4	82349077	82349077	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82349077delA	uc003hmi.1	-						RASGEF1B_uc003hmj.1_Intron|RASGEF1B_uc010ijq.1_Intron	NM_152545	NP_689758			RasGEF domain family, member 1B						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0																		---	---	---	---
RASGEF1B	153020	broad.mit.edu	37	4	82378070	82378071	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82378070_82378071insC	uc003hmi.1	-						RASGEF1B_uc003hmj.1_Intron|RASGEF1B_uc010ijq.1_Intron|RASGEF1B_uc003hmk.2_Intron	NM_152545	NP_689758			RasGEF domain family, member 1B						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0																		---	---	---	---
COPS4	51138	broad.mit.edu	37	4	83996434	83996434	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83996434delT	uc003hoa.2	+						COPS4_uc003hob.2_Intron|COPS4_uc010ijw.2_Intron|COPS4_uc010ijx.2_Intron	NM_016129	NP_057213			COP9 signalosome subunit 4						cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)																---	---	---	---
FAM175A	84142	broad.mit.edu	37	4	84390470	84390472	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84390470_84390472delTTT	uc003hou.2	-						FAM175A_uc003hot.2_5'UTR|FAM175A_uc003hov.2_Intron	NM_139076	NP_620775			coiled-coil domain containing 98						chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1																		---	---	---	---
WDFY3	23001	broad.mit.edu	37	4	85611498	85611499	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:85611498_85611499insT	uc003hpd.2	-							NM_014991	NP_055806			WD repeat and FYVE domain containing 3 isoform							cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)														---	---	---	---
MAPK10	5602	broad.mit.edu	37	4	87022066	87022066	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87022066delA	uc003hpq.2	-						MAPK10_uc010ikg.2_Intron|MAPK10_uc003hpr.2_Intron|MAPK10_uc003hps.2_Intron|MAPK10_uc003hpt.2_Intron|MAPK10_uc003hpu.2_Intron|MAPK10_uc003hpv.2_Intron|MAPK10_uc003hpn.2_5'Flank|MAPK10_uc003hpo.2_Intron|MAPK10_uc011ccw.1_Intron|MAPK10_uc003hpp.2_Intron	NM_138982	NP_620448			mitogen-activated protein kinase 10 isoform 2						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)														---	---	---	---
PTPN13	5783	broad.mit.edu	37	4	87717977	87717977	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87717977delT	uc003hpz.2	+						PTPN13_uc003hpy.2_Intron|PTPN13_uc003hqa.2_Intron|PTPN13_uc003hqb.2_Intron|PTPN13_uc003hqc.1_Intron	NM_080683	NP_542414			protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)														---	---	---	---
AFF1	4299	broad.mit.edu	37	4	87957969	87957970	+	Intron	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:87957969_87957970delTC	uc003hqj.3	+						AFF1_uc011ccx.1_Intron|AFF1_uc003hqh.1_Intron|AFF1_uc011ccy.1_Intron|AFF1_uc011ccz.1_Intron|AFF1_uc003hqk.3_Intron|AFF1_uc011cda.1_Intron	NM_005935	NP_005926			myeloid/lymphoid or mixed-lineage leukemia							nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)														---	---	---	---
SPARCL1	8404	broad.mit.edu	37	4	88394960	88394960	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88394960delA	uc010ikm.2	-						SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Intron|SPARCL1_uc011cdd.1_Intron	NM_001128310	NP_001121782			SPARC-like 1 precursor						signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)														---	---	---	---
SPARCL1	8404	broad.mit.edu	37	4	88411206	88411206	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88411206delA	uc010ikm.2	-						SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Intron|SPARCL1_uc011cdd.1_Intron	NM_001128310	NP_001121782			SPARC-like 1 precursor						signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)														---	---	---	---
SPARCL1	8404	broad.mit.edu	37	4	88415759	88415759	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88415759delA	uc010ikm.2	-						SPARCL1_uc011cdc.1_Intron|SPARCL1_uc003hqs.3_Intron|SPARCL1_uc011cdd.1_Intron|SPARCL1_uc003hqt.2_Intron	NM_001128310	NP_001121782			SPARC-like 1 precursor						signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.00118)														---	---	---	---
HERC6	55008	broad.mit.edu	37	4	89358213	89358213	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89358213delT	uc011cdi.1	+						HERC6_uc011cdj.1_Intron|HERC6_uc011cdk.1_Intron|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382			hect domain and RLD 6 isoform 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)														---	---	---	---
FAM13A	10144	broad.mit.edu	37	4	89950455	89950455	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89950455delT	uc003hse.1	-						FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsh.1_Intron|FAM13A_uc003hsi.2_Intron|FAM13A_uc003hsj.2_Intron	NM_014883	NP_055698			family with sequence similarity 13, member A1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2																		---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96199633	96199633	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96199633delT	uc003htp.1	-						UNC5C_uc010ilc.1_Intron|UNC5C_uc003htq.2_Intron	NM_003728	NP_003719			unc5C precursor						apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
ADH6	130	broad.mit.edu	37	4	100137538	100137538	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100137538delA	uc003hup.3	-						uc003hum.1_Intron|ADH6_uc003huo.2_Intron|ADH6_uc011cef.1_Intron|ADH6_uc010ile.2_Intron	NM_000672	NP_000663			class V alcohol dehydrogenase isoform 2						ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)													---	---	---	---
C4orf17	84103	broad.mit.edu	37	4	100443782	100443782	+	Frame_Shift_Del	DEL	T	-	-	rs13119384	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100443782delT	uc003huw.2	+	3	576	c.253delT	c.(253-255)CCGfs	p.P85fs	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	85											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)														---	---	---	---
MTTP	4547	broad.mit.edu	37	4	100542547	100542548	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:100542547_100542548insA	uc003hvc.3	+						MTTP_uc011cej.1_Intron	NM_000253	NP_000244			microsomal triglyceride transfer protein large						lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)													---	---	---	---
EMCN	51705	broad.mit.edu	37	4	101337124	101337124	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:101337124delA	uc003hvr.2	-						EMCN_uc011cel.1_Intron|EMCN_uc011cem.1_Intron	NM_016242	NP_057326			endomucin isoform 1							extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)														---	---	---	---
BANK1	55024	broad.mit.edu	37	4	102839361	102839362	+	Intron	DEL	TA	-	-	rs3733198	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:102839361_102839362delTA	uc003hvy.3	+						BANK1_uc003hvx.3_Intron|BANK1_uc010ill.2_Intron|BANK1_uc003hvz.3_Intron	NM_017935	NP_060405			B-cell scaffold protein with ankyrin repeats 1						B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	103383230	103383230	+	IGR	DEL	A	-	-	rs77311063	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103383230delA								SLC39A8 (116575 upstream) : NFKB1 (39256 downstream)																																			---	---	---	---
CENPE	1062	broad.mit.edu	37	4	104037852	104037852	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:104037852delT	uc003hxb.1	-						CENPE_uc003hxc.1_Intron	NM_001813	NP_001804			centromere protein E						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)														---	---	---	---
PPA2	27068	broad.mit.edu	37	4	106359209	106359210	+	Intron	INS	-	A	A	rs2713862	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:106359209_106359210insA	uc003hxl.2	-						PPA2_uc003hxm.2_Intron|PPA2_uc003hxn.2_Intron|PPA2_uc003hxo.2_Intron|PPA2_uc003hxp.2_Intron|PPA2_uc003hxq.2_Intron|PPA2_uc003hxr.2_Intron|PPA2_uc011cfa.1_Intron	NM_176869	NP_789845			inorganic pyrophosphatase 2 isoform 1 precursor						diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)														---	---	---	---
TBCK	93627	broad.mit.edu	37	4	107037270	107037270	+	Intron	DEL	T	-	-	rs79018134		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:107037270delT	uc010ilv.2	-						TBCK_uc003hyb.2_Intron|TBCK_uc003hye.2_Intron|TBCK_uc003hyc.2_Intron|TBCK_uc003hyd.2_Intron|TBCK_uc003hyf.2_Intron	NM_001163435	NP_001156907			TBC domain-containing protein kinase-like							intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5																		---	---	---	---
RPL34	6164	broad.mit.edu	37	4	109546421	109546421	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:109546421delT	uc003hyz.2	+						RPL34_uc003hza.2_Intron	NM_000995	NP_000986			ribosomal protein L34						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000286)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	111338793	111338793	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111338793delT								ELOVL6 (218973 upstream) : ENPEP (58436 downstream)																																			---	---	---	---
ENPEP	2028	broad.mit.edu	37	4	111480937	111480938	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:111480937_111480938insA	uc003iab.3	+							NM_001977	NP_001968			glutamyl aminopeptidase						cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)													---	---	---	---
C4orf32	132720	broad.mit.edu	37	4	113092292	113092292	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113092292delA	uc003iah.2	+							NM_152400	NP_689613			chromosome 4 open reading frame 32							integral to membrane					0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)														---	---	---	---
AP1AR	55435	broad.mit.edu	37	4	113186056	113186056	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113186056delT	uc003iaj.3	+						AP1AR_uc010imm.1_Intron|AP1AR_uc003iak.3_Intron	NM_018569	NP_061039			adaptor-related protein complex 1 associated						protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle					0																		---	---	---	---
LARP7	51574	broad.mit.edu	37	4	113567544	113567545	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113567544_113567545insA	uc003iay.2	+	3	518_519	c.240_241insA	c.(238-243)ATGAAAfs	p.M80fs	LARP7_uc003iaz.2_Frame_Shift_Ins_p.M87fs|LARP7_uc003iba.2_Frame_Shift_Ins_p.M1fs|LARP7_uc003ibb.2_Frame_Shift_Ins_p.M80fs	NM_016648	NP_057732	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	80_81	HTH La-type RNA-binding.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(3)	3		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)														---	---	---	---
LARP7	51574	broad.mit.edu	37	4	113574479	113574479	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113574479delT	uc003iay.2	+						LARP7_uc003iaz.2_Intron|LARP7_uc003iba.2_Intron|LARP7_uc003ibb.2_Intron	NM_016648	NP_057732			La ribonucleoprotein domain family, member 7						RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(3)	3		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114289147	114289147	+	Intron	DEL	A	-	-	rs55966162	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114289147delA	uc003ibe.3	+						ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Intron	NM_001148	NP_001139			ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)														---	---	---	---
Unknown	0	broad.mit.edu	37	4	119558972	119558973	+	IGR	DEL	TG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:119558972_119558973delTG								CEP170L (83615 upstream) : METTL14 (47601 downstream)																																			---	---	---	---
TNIP3	79931	broad.mit.edu	37	4	122068097	122068097	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122068097delA	uc010ing.2	-						TNIP3_uc010inh.2_Intron|TNIP3_uc011cgj.1_Intron	NM_024873	NP_079149			TNFAIP3 interacting protein 3											ovary(1)	1																		---	---	---	---
CCNA2	890	broad.mit.edu	37	4	122738866	122738866	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:122738866delT	uc003iec.3	-							NM_001237	NP_001228			cyclin A						cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123200862	123200863	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123200862_123200863insT	uc003ieh.2	+						KIAA1109_uc003iel.1_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123227333	123227333	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123227333delA	uc003ieh.2	+						KIAA1109_uc003iel.1_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
KIAA1109	84162	broad.mit.edu	37	4	123234945	123234945	+	Intron	DEL	A	-	-	rs72925991	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123234945delA	uc003ieh.2	+						KIAA1109_uc003iel.1_Intron	NM_015312	NP_056127			fragile site-associated protein						regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12																		---	---	---	---
ADAD1	132612	broad.mit.edu	37	4	123314648	123314649	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123314648_123314649insT	uc003ieo.2	+						ADAD1_uc003iep.2_Intron|ADAD1_uc003ieq.2_Intron	NM_139243	NP_640336			adenosine deaminase domain containing 1						multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0																		---	---	---	---
FAT4	79633	broad.mit.edu	37	4	126398215	126398215	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:126398215delA	uc003ifj.3	+						FAT4_uc011cgp.1_Intron|FAT4_uc003ifi.1_Intron	NM_024582	NP_078858			FAT tumor suppressor homolog 4 precursor						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18																		---	---	---	---
INTU	27152	broad.mit.edu	37	4	128564917	128564917	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128564917delA	uc003ifk.1	+	2	458	c.388delA	c.(388-390)AAAfs	p.K130fs	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	130										ovary(1)	1																		---	---	---	---
HSPA4L	22824	broad.mit.edu	37	4	128733853	128733854	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128733853_128733854delTT	uc003ifm.2	+						HSPA4L_uc010iny.1_Intron|HSPA4L_uc011cgr.1_Intron	NM_014278	NP_055093			heat shock 70kDa protein 4-like						protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
MFSD8	256471	broad.mit.edu	37	4	128851978	128851978	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:128851978delA	uc003ifp.2	-						MFSD8_uc011cgu.1_Intron|MFSD8_uc011cgv.1_Intron|MFSD8_uc011cgw.1_Intron|MFSD8_uc011cgx.1_Intron	NM_152778	NP_689991			major facilitator superfamily domain containing						cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2																		---	---	---	---
ZNF330	27309	broad.mit.edu	37	4	142151303	142151303	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:142151303delT	uc003iiq.3	+						ZNF330_uc011chl.1_Intron	NM_014487	NP_055302			zinc finger protein 330							chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)																	---	---	---	---
INPP4B	8821	broad.mit.edu	37	4	143043164	143043165	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:143043164_143043165insA	uc003iix.3	-						INPP4B_uc003iiw.3_Intron|INPP4B_uc011chm.1_Intron|INPP4B_uc011chn.1_Intron|INPP4B_uc011cho.1_Intron	NM_003866	NP_003857			inositol polyphosphate-4-phosphatase, type II,						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)																	---	---	---	---
ANAPC10	10393	broad.mit.edu	37	4	146003025	146003025	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:146003025delT	uc003iju.3	-						ANAPC10_uc003ijv.3_Intron|ANAPC10_uc003ijw.3_Intron	NM_014885	NP_055700			anaphase promoting complex subunit 10						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity				0	all_hematologic(180;0.151)																	---	---	---	---
TMEM184C	55751	broad.mit.edu	37	4	148555176	148555177	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148555176_148555177insA	uc003ila.3	+							NM_018241	NP_060711			transmembrane protein 184C							integral to membrane					0																		---	---	---	---
ARHGAP10	79658	broad.mit.edu	37	4	148744154	148744154	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:148744154delA	uc003ilf.2	+						ARHGAP10_uc003ile.1_Intron	NM_024605	NP_078881			Rho GTPase activating protein 10						apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			skin(2)|pancreas(1)|lung(1)	4	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)														---	---	---	---
DCLK2	166614	broad.mit.edu	37	4	151160754	151160754	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151160754delA	uc003ilm.3	+						DCLK2_uc003iln.3_Intron|DCLK2_uc003ilo.3_Intron|DCLK2_uc003ilp.3_Intron	NM_001040260	NP_001035350			doublecortin-like kinase 2 isoform a						intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)																	---	---	---	---
LRBA	987	broad.mit.edu	37	4	151198823	151198823	+	Intron	DEL	T	-	-	rs1870515	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151198823delT	uc010ipj.2	-						LRBA_uc010ipi.2_Intron|LRBA_uc003ils.3_Intron|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc003ilr.3_Intron	NM_006726	NP_006717			LPS-responsive vesicle trafficking, beach and							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
LRBA	987	broad.mit.edu	37	4	151765372	151765372	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151765372delA	uc010ipj.2	-						LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron	NM_006726	NP_006717			LPS-responsive vesicle trafficking, beach and							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
KIAA0922	23240	broad.mit.edu	37	4	154478042	154478042	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154478042delA	uc003inm.3	+						KIAA0922_uc010ipp.2_Intron|KIAA0922_uc010ipq.2_Intron	NM_015196	NP_056011			hypothetical protein LOC23240 isoform 2							integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
Unknown	0	broad.mit.edu	37	4	154579718	154579719	+	IGR	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154579718_154579719insG								KIAA0922 (21858 upstream) : TLR2 (25722 downstream)																																			---	---	---	---
TDO2	6999	broad.mit.edu	37	4	156839468	156839468	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:156839468delA	uc003ipf.1	+							NM_005651	NP_005642			tryptophan 2,3-dioxygenase						tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)													---	---	---	---
ETFDH	2110	broad.mit.edu	37	4	159603683	159603684	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159603683_159603684delTT	uc003iqb.2	+						ETFDH_uc011cjg.1_Intron|ETFDH_uc010iqr.2_Intron|ETFDH_uc011cjh.1_Intron|ETFDH_uc010iqs.2_Intron	NM_004453	NP_004444			electron-transferring-flavoprotein dehydrogenase						fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)														---	---	---	---
FNIP2	57600	broad.mit.edu	37	4	159754866	159754866	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:159754866delT	uc003iqe.3	+						FNIP2_uc003iqd.2_Frame_Shift_Del_p.G247fs	NM_020840	NP_065891			folliculin interacting protein 2						DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)														---	---	---	---
RAPGEF2	9693	broad.mit.edu	37	4	160251797	160251797	+	Intron	DEL	A	-	-	rs78225051		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:160251797delA	uc003iqg.3	+							NM_014247	NP_055062			Rap guanine nucleotide exchange factor 2						cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)														---	---	---	---
TLL1	7092	broad.mit.edu	37	4	166986765	166986765	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:166986765delT	uc003irh.1	+						TLL1_uc011cjn.1_Intron|TLL1_uc011cjo.1_Intron	NM_012464	NP_036596			tolloid-like 1 precursor						cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)														---	---	---	---
DDX60	55601	broad.mit.edu	37	4	169232227	169232227	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169232227delA	uc003irp.2	-							NM_017631	NP_060101			DEAD (Asp-Glu-Ala-Asp) box polypeptide 60								ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)														---	---	---	---
AADAT	51166	broad.mit.edu	37	4	170990213	170990213	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:170990213delA	uc003isr.2	-						AADAT_uc003iss.2_Intron|AADAT_uc003ist.2_Intron	NM_016228	NP_057312			kynurenine aminotransferase II						2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)													---	---	---	---
GALNTL6	442117	broad.mit.edu	37	4	173232962	173232962	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:173232962delT	uc003isv.2	+							NM_001034845	NP_001030017			N-acetylgalactosaminyltransferase-like 6							Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4																		---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183602941	183602942	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183602941_183602942insA	uc003ivd.1	+						ODZ3_uc003ive.1_Intron	NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
ODZ3	55714	broad.mit.edu	37	4	183710620	183710620	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:183710620delA	uc003ivd.1	+							NM_001080477	NP_001073946			odz, odd Oz/ten-m homolog 3						signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)														---	---	---	---
WWC2	80014	broad.mit.edu	37	4	184236973	184236973	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:184236973delT	uc010irx.2	+	23					WWC2_uc003ivk.3_3'UTR|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_3'UTR|WWC2_uc003ivn.3_3'UTR|WWC2_uc010irz.2_3'UTR|WWC2_uc003ivo.3_3'UTR	NM_024949	NP_079225			WW and C2 domain containing 2											ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)														---	---	---	---
ACSL1	2180	broad.mit.edu	37	4	185689743	185689743	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185689743delA	uc003iww.2	-						ACSL1_uc011ckm.1_Intron|ACSL1_uc003iwt.1_Intron|ACSL1_uc003iwu.1_Intron|ACSL1_uc011ckn.1_Intron|ACSL1_uc003iwv.1_Intron|ACSL1_uc003iws.1_5'Flank|ACSL1_uc010ise.1_Intron	NM_001995	NP_001986			acyl-CoA synthetase long-chain family member 1						digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)													---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187530942	187530942	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187530942delA	uc003izf.2	-							NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
FAT1	2195	broad.mit.edu	37	4	187532425	187532425	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:187532425delT	uc003izf.2	-							NM_005245	NP_005236			FAT tumor suppressor 1 precursor						actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12															HNSCC(5;0.00058)			---	---	---	---
SDHA	6389	broad.mit.edu	37	5	240458	240458	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:240458delT	uc003jao.3	+						SDHA_uc011clv.1_Intron|SDHA_uc011clw.1_Intron|SDHA_uc003jap.3_Intron|SDHA_uc003jaq.3_Intron|SDHA_uc003jar.3_Intron	NM_004168	NP_004159			succinate dehydrogenase complex, subunit A,						nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)									Familial_Paragangliomas				---	---	---	---
AHRR	57491	broad.mit.edu	37	5	433949	433949	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:433949delC	uc003jav.2	+						AHRR_uc003jaw.2_Intron|AHRR_uc010isy.2_Intron|AHRR_uc010isz.2_Intron|AHRR_uc003jax.2_Intron|AHRR_uc003jay.2_Intron|AHRR_uc003jaz.2_Intron	NM_020731	NP_065782			arylhydrocarbon receptor repressor						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)															---	---	---	---
SLC9A3	6550	broad.mit.edu	37	5	482152	482152	+	Intron	DEL	C	-	-	rs56916156		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:482152delC	uc003jbe.2	-						SLC9A3_uc011clx.1_Intron	NM_004174	NP_004165			solute carrier family 9 (sodium/hydrogen							cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)															---	---	---	---
SLC9A3	6550	broad.mit.edu	37	5	485394	485394	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:485394delC	uc003jbe.2	-						SLC9A3_uc011clx.1_Intron	NM_004174	NP_004165			solute carrier family 9 (sodium/hydrogen							cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)															---	---	---	---
MED10	84246	broad.mit.edu	37	5	6372636	6372636	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6372636delC	uc003jdo.2	-	4	431	c.388delG	c.(388-390)GAGfs	p.E130fs		NM_032286	NP_115662	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	130					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(1)	1																		---	---	---	---
NSUN2	54888	broad.mit.edu	37	5	6623158	6623159	+	Intron	DEL	AA	-	-	rs111573762		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:6623158_6623159delAA	uc003jdu.2	-						NSUN2_uc003jdt.2_5'Flank|NSUN2_uc011cmk.1_Intron|NSUN2_uc003jdv.2_Intron	NM_017755	NP_060225			NOL1/NOP2/Sun domain family, member 2							cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1																		---	---	---	---
MTRR	4552	broad.mit.edu	37	5	7885676	7885676	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:7885676delT	uc003jed.2	+						MTRR_uc010itn.1_Intron|MTRR_uc003jee.3_Intron|MTRR_uc003jef.3_Intron|MTRR_uc003jeg.3_Intron|MTRR_uc010ito.2_Intron	NM_024010	NP_076915			methionine synthase reductase isoform 2						methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)													---	---	---	---
MARCH6	10299	broad.mit.edu	37	5	10394133	10394133	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:10394133delT	uc003jet.1	+						MARCH6_uc011cmu.1_Intron|MARCH6_uc003jeu.1_Intron|MARCH6_uc011cmv.1_Intron	NM_005885	NP_005876			membrane-associated ring finger (C3HC4) 6						protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2																		---	---	---	---
DNAH5	1767	broad.mit.edu	37	5	13814977	13814977	+	Intron	DEL	A	-	-	rs116215381	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:13814977delA	uc003jfd.2	-							NM_001369	NP_001360			dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)													Kartagener_syndrome				---	---	---	---
TRIO	7204	broad.mit.edu	37	5	14489275	14489275	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:14489275delA	uc003jff.2	+						TRIO_uc003jfg.2_Intron	NM_007118	NP_009049			triple functional domain (PTPRF interacting)						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)																	---	---	---	---
RNASEN	29102	broad.mit.edu	37	5	31435976	31435976	+	Intron	DEL	A	-	-	rs77666632		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:31435976delA	uc003jhg.2	-						RNASEN_uc003jhh.2_Intron|RNASEN_uc003jhi.2_Intron	NM_013235	NP_037367			ribonuclease III, nuclear isoform 1						gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0																		---	---	---	---
SUB1	10923	broad.mit.edu	37	5	32601324	32601324	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:32601324delT	uc003jhs.2	+	5					SUB1_uc003jht.2_RNA	NM_006713	NP_006704			activated RNA polymerase II transcription						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus|transcription factor complex	protein binding|single-stranded DNA binding|transcription coactivator activity				0																		---	---	---	---
BRIX1	55299	broad.mit.edu	37	5	34922712	34922712	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:34922712delT	uc003jja.2	+						BRIX1_uc011col.1_Intron	NM_018321	NP_060791			BRIX						ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding				0																		---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	36985083	36985083	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:36985083delA	uc003jkl.3	+	10	2300	c.1801delA	c.(1801-1803)AAAfs	p.K601fs	NIPBL_uc003jkk.3_Frame_Shift_Del_p.K601fs|NIPBL_uc003jkm.1_Frame_Shift_Del_p.K480fs	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	601					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
C5orf42	65250	broad.mit.edu	37	5	37167150	37167150	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37167150delT	uc011cpa.1	-	35	7630	c.7399delA	c.(7399-7401)AGGfs	p.R2467fs	C5orf42_uc011coy.1_Frame_Shift_Del_p.R967fs|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Frame_Shift_Del_p.R1542fs	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2467										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)															---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38407192	38407192	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38407192delG	uc003jlc.1	+	8	1415	c.1091delG	c.(1090-1092)TGGfs	p.W364fs	EGFLAM_uc003jlb.1_Frame_Shift_Del_p.W364fs|EGFLAM_uc003jle.1_Frame_Shift_Del_p.W130fs|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	364	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
OSMR	9180	broad.mit.edu	37	5	38925278	38925279	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38925278_38925279insA	uc003jln.1	+						OSMR_uc011cpj.1_Intron	NM_003999	NP_003990			oncostatin M receptor precursor						cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)																	---	---	---	---
FYB	2533	broad.mit.edu	37	5	39119141	39119141	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39119141delA	uc003jls.2	-						FYB_uc003jlt.2_Intron|FYB_uc003jlu.2_Intron|FYB_uc011cpl.1_Intron	NM_199335	NP_955367			FYN binding protein (FYB-120/130) isoform 2						cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)															---	---	---	---
C9	735	broad.mit.edu	37	5	39285137	39285137	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39285137delT	uc003jlv.3	-	11						NM_001737	NP_001728			complement component 9 precursor						complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)															---	---	---	---
DAB2	1601	broad.mit.edu	37	5	39388473	39388473	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:39388473delA	uc003jlx.2	-						DAB2_uc003jlw.2_Intron	NM_001343	NP_001334			disabled homolog 2						cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)															---	---	---	---
C7	730	broad.mit.edu	37	5	40934740	40934740	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:40934740delT	uc003jmh.2	+						C7_uc011cpn.1_Intron	NM_000587	NP_000578			complement component 7 precursor						complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)																---	---	---	---
HEATR7B2	133558	broad.mit.edu	37	5	40999839	40999840	+	Frame_Shift_Ins	INS	-	GT	GT			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:40999839_40999840insGT	uc003jmj.3	-	40	5014_5015	c.4524_4525insAC	c.(4522-4527)CACTCCfs	p.H1508fs	HEATR7B2_uc003jmi.3_Frame_Shift_Ins_p.H1063fs	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1508_1509							binding			ovary(6)|central_nervous_system(2)	8																		---	---	---	---
HEATR7B2	133558	broad.mit.edu	37	5	41000852	41000852	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41000852delA	uc003jmj.3	-	38	4768	c.4278delT	c.(4276-4278)TTTfs	p.F1426fs	HEATR7B2_uc003jmi.3_Frame_Shift_Del_p.F981fs	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1426							binding			ovary(6)|central_nervous_system(2)	8																		---	---	---	---
OXCT1	5019	broad.mit.edu	37	5	41840641	41840641	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41840641delG	uc003jmn.2	-							NM_000436	NP_000427			3-oxoacid CoA transferase 1 precursor						cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)													---	---	---	---
NNT	23530	broad.mit.edu	37	5	43628533	43628533	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43628533delT	uc003joe.2	+						NNT_uc003jof.2_Intron	NM_012343	NP_036475			nicotinamide nucleotide transhydrogenase						tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)													---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50045917	50045918	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50045917_50045918insT	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50091305	50091306	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50091305_50091306insT	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50092791	50092791	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50092791delT	uc003jon.3	+						PARP8_uc011cpz.1_Intron|PARP8_uc003joo.2_Intron|PARP8_uc003jop.2_Intron	NM_024615	NP_078891			poly (ADP-ribose) polymerase family, member 8							intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
ITGA2	3673	broad.mit.edu	37	5	52370823	52370823	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52370823delT	uc003joy.2	+						ITGA2_uc011cqa.1_Intron|ITGA2_uc011cqb.1_Intron|ITGA2_uc011cqc.1_Intron|ITGA2_uc011cqd.1_Intron|ITGA2_uc011cqe.1_Intron	NM_002203	NP_002194			integrin alpha 2 precursor						axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)																---	---	---	---
MOCS2	4338	broad.mit.edu	37	5	52404220	52404220	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:52404220delA	uc011cqf.1	-						MOCS2_uc003joz.2_Intron|uc003jpb.1_5'Flank	NM_176806	NP_789776			molybdopterin synthase small subunit MOCS2A						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex	nucleotide binding				0		Lung NSC(810;3.08e-05)|Breast(144;0.0848)																---	---	---	---
GPX8	493869	broad.mit.edu	37	5	54460113	54460113	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54460113delT	uc003jpq.2	+	3					CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc003jpo.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|GPX8_uc003jpr.2_3'UTR|GPX8_uc003jps.2_RNA|GPX8_uc003jpt.2_3'UTR	NM_001008397	NP_001008398			glutathione peroxidase 8						response to oxidative stress	integral to membrane	glutathione peroxidase activity				0					Glutathione(DB00143)													---	---	---	---
DHX29	54505	broad.mit.edu	37	5	54586202	54586202	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54586202delA	uc003jpx.2	-						DHX29_uc010ivw.2_Intron	NM_019030	NP_061903			DEAH (Asp-Glu-Ala-His) box polypeptide 29								ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)																---	---	---	---
SKIV2L2	23517	broad.mit.edu	37	5	54662536	54662536	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:54662536delT	uc003jpy.3	+						SKIV2L2_uc011cqi.1_Intron	NM_015360	NP_056175			superkiller viralicidic activity 2-like 2						maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)																---	---	---	---
DDX4	54514	broad.mit.edu	37	5	55082328	55082328	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55082328delT	uc003jqg.3	+						DDX4_uc010ivz.2_Intron|DDX4_uc003jqh.3_Intron|DDX4_uc003jqj.2_Intron	NM_001136034	NP_001129506			DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform						multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)																---	---	---	---
KIF2A	3796	broad.mit.edu	37	5	61649212	61649213	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:61649212_61649213delAT	uc003jsy.3	+						KIF2A_uc003jsz.3_Intron|KIF2A_uc010iwp.2_Intron|KIF2A_uc003jsx.3_Intron|KIF2A_uc010iwq.2_Intron	NM_004520	NP_004511			kinesin heavy chain member 2 isoform 1						blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)														---	---	---	---
SFRS12IP1	285672	broad.mit.edu	37	5	64020521	64020521	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64020521delA	uc003jtk.2	-							NM_173829	NP_776190			P18SRP protein						mRNA processing|RNA splicing		nucleic acid binding|zinc ion binding				0		Lung NSC(167;1.66e-05)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.119)														---	---	---	---
CWC27	10283	broad.mit.edu	37	5	64084763	64084763	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64084763delT	uc003jtn.1	+						CWC27_uc003jtl.2_Intron|CWC27_uc003jtm.2_Intron|CWC27_uc010iwt.1_Intron	NM_005869	NP_005860			serologically defined colon cancer antigen 10						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0																		---	---	---	---
PPWD1	23398	broad.mit.edu	37	5	64863326	64863326	+	Intron	DEL	T	-	-	rs71674730		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64863326delT	uc003jtv.3	+						PPWD1_uc011cqv.1_Intron|PPWD1_uc011cqw.1_Intron	NM_015342	NP_056157			peptidylprolyl isomerase domain and WD repeat						protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)														---	---	---	---
C5orf44	80006	broad.mit.edu	37	5	64933654	64933654	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:64933654delT	uc003jtz.3	+						C5orf44_uc003jua.3_Intron|C5orf44_uc003juc.3_Intron|C5orf44_uc010iwv.2_Intron	NM_024941	NP_079217			hypothetical protein LOC80006 isoform 2											ovary(1)	1																		---	---	---	---
NLN	57486	broad.mit.edu	37	5	65105313	65105314	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:65105313_65105314insA	uc003juf.2	+						NLN_uc003jug.2_Intron|NLN_uc010iww.2_Intron	NM_020726	NP_065777			neurolysin precursor						proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)														---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66391517	66391518	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66391517_66391518delTT	uc003jut.1	+						MAST4_uc003jus.2_Intron|MAST4_uc003juu.1_Intron|MAST4_uc011cra.1_Intron|MAST4_uc010ixa.2_Intron|MAST4_uc003juv.2_Intron|MAST4_uc003juw.2_Intron	NM_015183	NP_055998			microtubule associated serine/threonine kinase							cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
PIK3R1	5295	broad.mit.edu	37	5	67522741	67522741	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:67522741delA	uc003jva.2	+	2	798	c.238delA	c.(238-240)AAAfs	p.K80fs	PIK3R1_uc003jvb.2_Frame_Shift_Del_p.K80fs	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	80					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding			endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			---	---	---	---
BDP1	55814	broad.mit.edu	37	5	70779611	70779611	+	Intron	DEL	A	-	-	rs11953420	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70779611delA	uc003kbp.1	+						BDP1_uc003kbn.1_Intron|BDP1_uc003kbo.2_Intron	NM_018429	NP_060899			transcription factor-like nuclear regulator						regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)														---	---	---	---
BDP1	55814	broad.mit.edu	37	5	70800642	70800642	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:70800642delT	uc003kbp.1	+						BDP1_uc003kbn.1_Intron|BDP1_uc003kbo.2_Intron	NM_018429	NP_060899			transcription factor-like nuclear regulator						regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)														---	---	---	---
MRPS27	23107	broad.mit.edu	37	5	71593573	71593574	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:71593573_71593574insT	uc003kbz.3	-						MRPS27_uc003kca.3_Intron|MRPS27_uc011cse.1_Intron|MRPS27_uc010iza.2_Intron	NM_015084	NP_055899			mitochondrial ribosomal protein S27							mitochondrion|ribosome					0		Lung NSC(167;0.00237)|Ovarian(174;0.0175)|Prostate(461;0.141)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-53)														---	---	---	---
CRHBP	1393	broad.mit.edu	37	5	76258951	76258951	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:76258951delA	uc003ker.2	+							NM_001882	NP_001873			corticotropin releasing hormone binding protein						female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)														---	---	---	---
MTX3	345778	broad.mit.edu	37	5	79285073	79285073	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79285073delA	uc010jag.2	-						MTX3_uc010jah.2_Intron|MTX3_uc003kge.3_Intron|MTX3_uc003kgf.1_5'Flank	NM_001010891	NP_001010891			metaxin 3						protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)														---	---	---	---
MSH3	4437	broad.mit.edu	37	5	80021182	80021183	+	Intron	DEL	TT	-	-	rs79974413		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80021182_80021183delTT	uc003kgz.2	+							NM_002439	NP_002430			mutS homolog 3						maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)									MMR					---	---	---	---
RASGRF2	5924	broad.mit.edu	37	5	80382885	80382886	+	Intron	INS	-	C	C	rs142350979	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:80382885_80382886insC	uc003kha.1	+						RASGRF2_uc011ctn.1_Intron|RASGRF2_uc003khb.1_Intron	NM_006909	NP_008840			Ras protein-specific guanine						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(5)|ovary(3)|large_intestine(2)|central_nervous_system(1)|skin(1)	12		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)														---	---	---	---
TMEM167A	153339	broad.mit.edu	37	5	82352893	82352893	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82352893delT	uc003khx.3	-	4						NM_174909	NP_777569			transmembrane protein 167A precursor							Golgi membrane|integral to membrane					0																		---	---	---	---
VCAN	1462	broad.mit.edu	37	5	82807909	82807910	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82807909_82807910insT	uc003kii.3	+						VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kih.3_Intron	NM_004385	NP_004376			versican isoform 1 precursor						cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)														---	---	---	---
COX7C	1350	broad.mit.edu	37	5	85913794	85913794	+	5'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:85913794delA	uc003kir.2	+	1						NM_001867	NP_001858			cytochrome c oxidase subunit VIIc precursor						respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity				0		all_cancers(142;7e-06)|Lung NSC(167;0.000601)|all_lung(232;0.000693)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;1.56e-40)|Epithelial(54;3.17e-34)|all cancers(79;3.36e-29)														---	---	---	---
CCNH	902	broad.mit.edu	37	5	86697604	86697604	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:86697604delA	uc003kjb.2	-						CCNH_uc003kiy.1_Intron|CCNH_uc003kiz.1_Intron|CCNH_uc003kja.2_Intron	NM_001239	NP_001230			cyclin H						G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)									Direct_reversal_of_damage|NER					---	---	---	---
TMEM161B	153396	broad.mit.edu	37	5	87491918	87491918	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:87491918delT	uc003kjc.2	-	12					TMEM161B_uc011cty.1_3'UTR|TMEM161B_uc010jax.2_RNA|TMEM161B_uc011ctx.1_3'UTR	NM_153354	NP_699185			transmembrane protein 161B							integral to membrane				skin(2)	2		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	88215000	88215000	+	Intron	DEL	T	-	-	rs75521163		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:88215000delT	uc003kjn.1	+											Homo sapiens mRNA; cDNA DKFZp586I041 (from clone DKFZp586I041).																														---	---	---	---
POLR3G	10622	broad.mit.edu	37	5	89791610	89791610	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89791610delT	uc003kjq.2	+						POLR3G_uc011cuc.1_Intron	NM_006467	NP_006458			polymerase (RNA) III (DNA directed) polypeptide						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity				0		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	90002260	90002260	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:90002260delT	uc003kju.2	+						GPR98_uc003kjt.2_Intron|GPR98_uc003kjv.2_Intron	NM_032119	NP_115495			G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	90398017	90398018	+	Intron	INS	-	T	T	rs140911567		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:90398017_90398018insT	uc003kju.2	+						GPR98_uc003kjt.2_Intron|GPR98_uc003kjw.2_Intron|GPR98_uc003kjx.2_Intron	NM_032119	NP_115495			G protein-coupled receptor 98 precursor						cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)												OREG0016703	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TTC37	9652	broad.mit.edu	37	5	94879039	94879039	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:94879039delA	uc003klb.2	-						TTC37_uc010jbf.1_Intron	NM_014639	NP_055454			tetratricopeptide repeat domain 37								binding			ovary(3)|pancreas(1)	4																		---	---	---	---
CHD1	1105	broad.mit.edu	37	5	98228483	98228483	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:98228483delT	uc003knf.2	-							NM_001270	NP_001261			chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)													---	---	---	---
PAM	5066	broad.mit.edu	37	5	102355626	102355626	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:102355626delA	uc003knw.2	+						PAM_uc003kns.2_Intron|PAM_uc003knt.2_Intron|PAM_uc003knu.2_Intron|PAM_uc003knv.2_Intron|PAM_uc011cuz.1_Intron|PAM_uc003knz.2_Intron	NM_000919	NP_000910			peptidylglycine alpha-amidating monooxygenase						peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding				0		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)													---	---	---	---
MAN2A1	4124	broad.mit.edu	37	5	109202859	109202867	+	3'UTR	DEL	AAAAAAAAA	-	-	rs11351742		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:109202859_109202867delAAAAAAAAA	uc003kou.1	+	22						NM_002372	NP_002363			mannosidase, alpha, class 2A, member 1						mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)														---	---	---	---
SLC25A46	91137	broad.mit.edu	37	5	110077935	110077935	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110077935delA	uc003koz.2	+						SLC25A46_uc011cvi.1_Intron	NM_138773	NP_620128			solute carrier family 25, member 46						transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)														---	---	---	---
WDR36	134430	broad.mit.edu	37	5	110456679	110456679	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:110456679delA	uc003kpd.2	+						WDR36_uc010jbu.2_Intron	NM_139281	NP_644810			WD repeat domain 36						response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)														---	---	---	---
YTHDC2	64848	broad.mit.edu	37	5	112862206	112862206	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112862206delA	uc003kqn.2	+						YTHDC2_uc010jce.1_Intron|YTHDC2_uc010jcf.1_Intron	NM_022828	NP_073739			YTH domain containing 2								ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118450360	118450361	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118450360_118450361insT	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron|DMXL1_uc003ksc.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118479641	118479641	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118479641delG	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118502294	118502294	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118502294delT	uc003ksd.2	+						DMXL1_uc010jcl.1_Intron	NM_005509	NP_005500			Dmx-like 1											ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
CEP120	153241	broad.mit.edu	37	5	122708545	122708545	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122708545delT	uc003ktk.2	-						CEP120_uc011cwq.1_Intron	NM_153223	NP_694955			coiled-coil domain containing 100							centrosome				ovary(1)	1																		---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122924299	122924299	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122924299delA	uc003ktm.2	+						CSNK1G3_uc003ktl.2_Intron|CSNK1G3_uc003ktn.2_Intron|CSNK1G3_uc003kto.2_Intron|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Intron	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122926143	122926144	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122926143_122926144insT	uc003ktm.2	+	9	1600_1601	c.881_882insT	c.(880-882)GATfs	p.D294fs	CSNK1G3_uc003ktl.2_Frame_Shift_Ins_p.D294fs|CSNK1G3_uc003ktn.2_Frame_Shift_Ins_p.D294fs|CSNK1G3_uc003kto.2_Frame_Shift_Ins_p.D294fs|CSNK1G3_uc011cwr.1_Frame_Shift_Ins_p.D219fs|CSNK1G3_uc011cws.1_Frame_Shift_Ins_p.D182fs|CSNK1G3_uc010jda.2_Frame_Shift_Ins_p.D295fs	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	294	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
CSNK1G3	1456	broad.mit.edu	37	5	122950255	122950256	+	3'UTR	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:122950255_122950256delTT	uc003ktm.2	+	13					CSNK1G3_uc003ktl.2_3'UTR|CSNK1G3_uc003ktn.2_3'UTR|CSNK1G3_uc003kto.2_3'UTR|CSNK1G3_uc011cwr.1_3'UTR|CSNK1G3_uc011cws.1_3'UTR|CSNK1G3_uc010jda.2_3'UTR	NM_004384	NP_004375			casein kinase 1, gamma 3 isoform 1						Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)														---	---	---	---
ALDH7A1	501	broad.mit.edu	37	5	125895141	125895145	+	Intron	DEL	TTTTG	-	-	rs79273314		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:125895141_125895145delTTTTG	uc003ktx.2	-						ALDH7A1_uc003ktv.2_Intron|ALDH7A1_uc003kty.2_Intron|ALDH7A1_uc011cxa.1_Intron	NM_001182	NP_001173			aldehyde dehydrogenase 7 family, member A1						cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			kidney(2)|ovary(1)	3		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)													---	---	---	---
Unknown	0	broad.mit.edu	37	5	126479266	126479266	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126479266delT								FLJ44606 (70094 upstream) : MEGF10 (147190 downstream)																																			---	---	---	---
MEGF10	84466	broad.mit.edu	37	5	126770267	126770267	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126770267delT	uc003kuh.3	+						MEGF10_uc003kui.3_Intron	NM_032446	NP_115822			multiple EGF-like-domains 10 precursor						cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)														---	---	---	---
Unknown	0	broad.mit.edu	37	5	126847110	126847110	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:126847110delA								MEGF10 (50202 upstream) : PRRC1 (6199 downstream)																																			---	---	---	---
LYRM7	90624	broad.mit.edu	37	5	130515638	130515638	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130515638delT	uc003kvg.1	+							NM_181705	NP_859056			Lyrm7 homolog												0		all_cancers(142;0.0377)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
CDC42SE2	56990	broad.mit.edu	37	5	130726550	130726550	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130726550delA	uc003kvh.2	+						CDC42SE2_uc003kvi.2_Intron|CDC42SE2_uc003kvj.2_Intron|CDC42SE2_uc003kvk.2_Intron|CDC42SE2_uc003kvl.2_Intron	NM_020240	NP_064625			CDC42 small effector 2						phagocytosis|regulation of cell shape|regulation of signal transduction	cell projection|cytoplasm|cytoskeleton|phagocytic cup	protein binding|structural molecule activity				0		all_cancers(142;0.0525)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
RAPGEF6	51735	broad.mit.edu	37	5	130897900	130897900	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:130897900delA	uc003kvn.1	-						RAPGEF6_uc003kvp.1_Intron|RAPGEF6_uc003kvo.1_Intron|RAPGEF6_uc010jdi.1_Intron|RAPGEF6_uc010jdj.1_Intron|RAPGEF6_uc003kvr.2_Intron|RAPGEF6_uc011cxe.1_Intron|RAPGEF6_uc010jdk.2_Intron	NM_016340	NP_057424			PDZ domain-containing guanine nucleotide						Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)														---	---	---	---
ZCCHC10	54819	broad.mit.edu	37	5	132334610	132334610	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:132334610delT	uc003kyh.2	-						ZCCHC10_uc003kyg.2_Intron|ZCCHC10_uc011cxl.1_Intron	NM_017665	NP_060135			zinc finger, CCHC domain containing 10								nucleic acid binding|zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
SKP1	6500	broad.mit.edu	37	5	133503083	133503083	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:133503083delA	uc003kzc.3	-						SKP1_uc003kzd.3_Intron|SKP1_uc010jdv.2_Intron	NM_170679	NP_733779			S-phase kinase-associated protein 1 isoform b						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)															---	---	---	---
TRPC7	57113	broad.mit.edu	37	5	135610472	135610473	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:135610472_135610473insT	uc003lbn.1	-	3	1016_1017	c.1013_1014insA	c.(1012-1014)AATfs	p.N338fs	TRPC7_uc010jef.1_Intron|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Frame_Shift_Ins_p.N269fs|TRPC7_uc010jei.1_Intron|TRPC7_uc010jej.1_Intron	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	339	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
SPOCK1	6695	broad.mit.edu	37	5	136328035	136328035	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:136328035delT	uc003lbo.2	-						SPOCK1_uc003lbp.2_Intron	NM_004598	NP_004589			sparc/osteonectin, cwcv and kazal-like domains						cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
MYOT	9499	broad.mit.edu	37	5	137206445	137206448	+	Frame_Shift_Del	DEL	CAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137206445_137206448delCAAA	uc011cye.1	+	2	122_125	c.105_108delCAAA	c.(103-108)ACCAAAfs	p.T35fs	MYOT_uc003lbv.2_Frame_Shift_Del_p.T35fs|MYOT_uc011cyg.1_Intron|MYOT_uc011cyh.1_Intron	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	35_36					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
BRD8	10902	broad.mit.edu	37	5	137496760	137496760	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137496760delA	uc003lcf.1	-						BRD8_uc003lcc.1_Intron|BRD8_uc011cyl.1_Intron|BRD8_uc003lcg.2_Intron|BRD8_uc003lci.2_Intron|BRD8_uc003lch.2_Intron|BRD8_uc011cym.1_Intron|BRD8_uc010jer.1_Intron|BRD8_uc011cyn.1_Intron	NM_139199	NP_631938			bromodomain containing 8 isoform 2						cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
PCDHB4	56131	broad.mit.edu	37	5	140502701	140502701	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140502701delC	uc003lip.1	+	1	1121	c.1121delC	c.(1120-1122)TCCfs	p.S374fs		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	374	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGA10	56106	broad.mit.edu	37	5	140795209	140795209	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140795209delA	uc003lkl.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Frame_Shift_Del_p.K823fs|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736			protocadherin gamma subfamily A, 10 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA11	56105	broad.mit.edu	37	5	140803318	140803318	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140803318delG	uc003lkq.1	+						PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_3'UTR|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737			protocadherin gamma subfamily A, 11 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
LARS	51520	broad.mit.edu	37	5	145524124	145524124	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:145524124delT	uc003lnx.1	-						LARS_uc011dbq.1_Intron|LARS_uc011dbr.1_Intron|LARS_uc011dbs.1_Intron	NM_020117	NP_064502			leucyl-tRNA synthetase						leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)													---	---	---	---
JAKMIP2	9832	broad.mit.edu	37	5	147012450	147012450	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147012450delA	uc003loq.1	-						JAKMIP2_uc011dbx.1_Intron|JAKMIP2_uc003lor.1_Intron|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Intron	NM_014790	NP_055605			janus kinase and microtubule interacting protein							Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SPINK7	84651	broad.mit.edu	37	5	147692956	147692956	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:147692956delA	uc003lpd.2	+	2	138	c.81delA	c.(79-81)CCAfs	p.P27fs	uc003lpb.1_Intron	NM_032566	NP_115955	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7	27	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PDGFRB	5159	broad.mit.edu	37	5	149497102	149497113	+	Intron	DEL	CGCGCGCACACA	-	-	rs72246615	by1000genomes;by1000genomes;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:149497102_149497113delCGCGCGCACACA	uc003lro.2	-						PDGFRB_uc010jhd.2_Intron	NM_002609	NP_002600			platelet-derived growth factor receptor beta						aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			central_nervous_system(4)|lung(4)|breast(3)|stomach(2)|prostate(2)|large_intestine(1)|ovary(1)	17		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)			T	ETV6|TRIP11|HIP1|RAB5EP|H4|NIN|HCMOGT-1|PDE4DIP	MPD|AML|CMML|CML								---	---	---	---
G3BP1	10146	broad.mit.edu	37	5	151177029	151177029	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151177029delT	uc003lun.2	+						G3BP1_uc003lum.2_Intron|G3BP1_uc011dcu.1_Intron|G3BP1_uc010jhz.2_Intron|G3BP1_uc003luq.2_Intron	NM_005754	NP_005745			Ras-GTPase-activating protein SH3-domain-binding						Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)															---	---	---	---
G3BP1	10146	broad.mit.edu	37	5	151180020	151180020	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:151180020delA	uc003lun.2	+						G3BP1_uc003lum.2_Intron|G3BP1_uc011dcu.1_Intron|G3BP1_uc010jhz.2_Intron|G3BP1_uc003luq.2_Intron	NM_005754	NP_005745			Ras-GTPase-activating protein SH3-domain-binding						Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)															---	---	---	---
LARP1	23367	broad.mit.edu	37	5	154170383	154170383	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154170383delT	uc003lvp.2	+						LARP1_uc003lvo.2_Intron|LARP1_uc010jie.1_Intron	NM_033551	NP_291029			la related protein isoform 2								protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
GEMIN5	25929	broad.mit.edu	37	5	154305380	154305380	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154305380delA	uc003lvx.3	-						GEMIN5_uc011ddk.1_Intron	NM_015465	NP_056280			gemin 5						ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)															---	---	---	---
Unknown	0	broad.mit.edu	37	5	154873106	154873106	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:154873106delA								KIF4B (475421 upstream) : SGCD (261957 downstream)																																			---	---	---	---
HAVCR1	26762	broad.mit.edu	37	5	156469527	156469527	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156469527delA	uc010jij.1	-						HAVCR1_uc011ddl.1_Intron|HAVCR1_uc003lwi.2_Intron	NM_001099414	NP_001092884			hepatitis A virus cellular receptor 1						interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)															---	---	---	---
ADAM19	8728	broad.mit.edu	37	5	156899321	156899322	+	Intron	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156899321_156899322delTC	uc003lww.1	-						NIPAL4_uc003lwx.3_Intron|NIPAL4_uc011ddq.1_Intron					SubName: Full=cDNA FLJ34145 fis, clone FCBBF3011867, highly similar to ADAM 19 (EC 3.4.24.-);						proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)													OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RNF145	153830	broad.mit.edu	37	5	158608883	158608883	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:158608883delA	uc003lxp.2	-						RNF145_uc011ddy.1_Intron|RNF145_uc003lxo.1_Intron|RNF145_uc011ddz.1_Intron|RNF145_uc010jiq.1_Intron|RNF145_uc011dea.1_Intron	NM_144726	NP_653327			ring finger protein 145							integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
ATP10B	23120	broad.mit.edu	37	5	160025551	160025551	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:160025551delA	uc003lym.1	-						ATP10B_uc010jit.1_Intron	NM_025153	NP_079429			ATPase, class V, type 10B						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
Unknown	0	broad.mit.edu	37	5	165455504	165455505	+	IGR	DEL	TA	-	-	rs71282177		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:165455504_165455505delTA								None (None upstream) : None (None downstream)																																			---	---	---	---
ODZ2	57451	broad.mit.edu	37	5	167379581	167379581	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167379581delT	uc010jjd.2	+						ODZ2_uc003lzq.2_Intron|ODZ2_uc003lzr.3_Intron	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)														---	---	---	---
CCDC99	54908	broad.mit.edu	37	5	169015404	169015404	+	5'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:169015404delA	uc003mae.3	+	2					CCDC99_uc010jjj.2_5'UTR|CCDC99_uc011deq.1_5'UTR|CCDC99_uc010jjk.2_5'UTR	NM_017785	NP_060255			coiled-coil domain containing 99						cell division|establishment of mitotic spindle orientation|mitotic metaphase plate congression|mitotic prometaphase|protein localization to kinetochore	condensed chromosome outer kinetochore|cytosol|microtubule organizing center|nucleus|spindle pole	kinetochore binding|protein binding			ovary(1)|liver(1)	2	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
FBXW11	23291	broad.mit.edu	37	5	171337817	171337817	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171337817delA	uc003mbm.1	-						FBXW11_uc011dey.1_Intron|FBXW11_uc003mbl.1_Intron|FBXW11_uc003mbn.1_Intron	NM_012300	NP_036432			F-box and WD repeat domain containing 11 isoform						cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)|breast(1)	2	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
UBTD2	92181	broad.mit.edu	37	5	171661011	171661011	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:171661011delA	uc003mbp.1	-							NM_152277	NP_689490			dendritic cell-derived ubiquitin-like protein							cytoplasm					0	Renal(175;0.000159)|Lung NSC(126;0.00976)|all_lung(126;0.0156)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)															---	---	---	---
SFXN1	94081	broad.mit.edu	37	5	174949356	174949356	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:174949356delT	uc003mda.2	+						SFXN1_uc003mdb.1_Intron	NM_022754	NP_073591			sideroflexin 1						iron ion homeostasis	integral to membrane	cation transmembrane transporter activity|protein binding			ovary(1)	1	all_cancers(89;0.00922)|Renal(175;0.000269)|Lung NSC(126;0.00515)|all_lung(126;0.00873)	Medulloblastoma(196;0.0399)|all_neural(177;0.0663)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)															---	---	---	---
KIAA1191	57179	broad.mit.edu	37	5	175774902	175774902	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175774902delT	uc003mdw.2	-						KIAA1191_uc003mdx.2_Intron|KIAA1191_uc003mdy.2_Intron|KIAA1191_uc003mea.2_Intron|KIAA1191_uc003mdz.2_Intron	NM_020444	NP_065177			hypothetical protein LOC57179 isoform a								protein binding			ovary(1)	1	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)														---	---	---	---
RNF44	22838	broad.mit.edu	37	5	175957911	175957911	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:175957911delG	uc003mek.1	-	5	1102	c.577delC	c.(577-579)CAGfs	p.Q193fs	RNF44_uc011dfo.1_Frame_Shift_Del_p.Q101fs|RNF44_uc003mel.1_5'Flank	NM_014901	NP_055716	Q7L0R7	RNF44_HUMAN	ring finger protein 44	193	Pro-rich.						zinc ion binding				0	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
UIMC1	51720	broad.mit.edu	37	5	176397604	176397604	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176397604delA	uc011dfp.1	-						UIMC1_uc003mfc.1_Intron|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mfh.1_Intron|UIMC1_uc010jkj.1_Intron|UIMC1_uc011dfq.1_3'UTR|UIMC1_uc003mff.1_5'Flank	NM_016290	NP_057374			ubiquitin interaction motif containing 1						double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
UIMC1	51720	broad.mit.edu	37	5	176409714	176409714	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176409714delT	uc011dfp.1	-						UIMC1_uc003mfc.1_Intron|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mfh.1_Intron|UIMC1_uc010jkj.1_Intron|UIMC1_uc011dfq.1_Intron	NM_016290	NP_057374			ubiquitin interaction motif containing 1						double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
F12	2161	broad.mit.edu	37	5	176830623	176830623	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176830623delG	uc003mgo.3	-						PFN3_uc003mgl.2_5'Flank|F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_Intron	NM_000505	NP_000496			coagulation factor XII precursor						Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)											Hereditary_Angioedema				---	---	---	---
F12	2161	broad.mit.edu	37	5	176831178	176831178	+	Intron	DEL	C	-	-	rs67902409		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176831178delC	uc003mgo.3	-						F12_uc011dfy.1_Intron|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_Intron	NM_000505	NP_000496			coagulation factor XII precursor						Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)											Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
GRM6	2916	broad.mit.edu	37	5	178418555	178418555	+	Frame_Shift_Del	DEL	C	-	-	rs63062360		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:178418555delC	uc003mjr.2	-	3	906	c.727delG	c.(727-729)GTCfs	p.V243fs	GRM6_uc010jla.1_5'Flank|GRM6_uc003mjs.1_5'Flank	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	243	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)														---	---	---	---
CANX	821	broad.mit.edu	37	5	179135170	179135170	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179135170delT	uc003mkk.2	+						CANX_uc011dgp.1_Intron|CANX_uc010jlb.1_Intron|CANX_uc003mkl.2_Intron|CANX_uc011dgq.1_Intron	NM_001746	NP_001737			calnexin precursor						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
EXOC2	55770	broad.mit.edu	37	6	499548	499548	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:499548delA	uc003mtd.2	-						EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773			Sec5 protein						exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)														---	---	---	---
PRPF4B	8899	broad.mit.edu	37	6	4031881	4031881	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4031881delA	uc003mvv.2	+	2	221	c.130delA	c.(130-132)AAAfs	p.K44fs	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	44	His-rich.|Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
PRPF4B	8899	broad.mit.edu	37	6	4059124	4059124	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:4059124delA	uc003mvv.2	+						PRPF4B_uc003mvw.2_Intron|C6orf146_uc010jnq.1_Intron|PRPF4B_uc011dhv.1_Intron	NM_003913	NP_003904			serine/threonine-protein kinase PRP4K							catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)																---	---	---	---
SLC35B3	51000	broad.mit.edu	37	6	8417377	8417377	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:8417377delA	uc010joe.2	-						SLC35B3_uc003mya.2_Intron|SLC35B3_uc003myc.2_Intron|SLC35B3_uc003myb.2_Intron|SLC35B3_uc011did.1_Intron|SLC35B3_uc003myd.2_Intron	NM_001142541	NP_001136013			solute carrier family 35, member B3						transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)																	---	---	---	---
SYCP2L	221711	broad.mit.edu	37	6	10910343	10910343	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:10910343delT	uc003mzo.2	+						SYCP2L_uc011din.1_Intron|SYCP2L_uc010jow.2_Intron	NM_001040274	NP_001035364			synaptonemal complex protein 2-like							nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)															---	---	---	---
FAM8A1	51439	broad.mit.edu	37	6	17605070	17605070	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17605070delA	uc003ncc.2	+							NM_016255	NP_057339			family with sequence similarity 8, member A1							integral to membrane					0	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)															---	---	---	---
NUP153	9972	broad.mit.edu	37	6	17669313	17669314	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:17669313_17669314delTT	uc003ncd.1	-						NUP153_uc011dje.1_Intron|NUP153_uc010jpl.1_Intron	NM_005124	NP_005115			nucleoporin 153kDa						carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)															---	---	---	---
KDM1B	221656	broad.mit.edu	37	6	18222307	18222307	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:18222307delA	uc003nco.1	+	15					KDM1B_uc003ncn.1_3'UTR|KDM1B_uc003ncp.1_3'UTR|KDM1B_uc003ncq.1_Frame_Shift_Del_p.K203fs	NM_153042	NP_694587			amine oxidase (flavin containing) domain 1						multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1																		---	---	---	---
MRS2	57380	broad.mit.edu	37	6	24423946	24423946	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24423946delT	uc003neb.2	+	11					MRS2_uc011djl.1_3'UTR|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_3'UTR|MRS2_uc003nec.2_3'UTR	NM_020662	NP_065713			MRS2-like, magnesium homeostasis factor						ion transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
HIST1H4F	8361	broad.mit.edu	37	6	26240972	26240972	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26240972delC	uc003nhe.1	+	1						NM_003540	NP_003531			histone cluster 1, H4f						CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding				0		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)																---	---	---	---
Unknown	0	broad.mit.edu	37	6	29068729	29068729	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29068729delA								OR2B3 (13639 upstream) : OR2J3 (10939 downstream)																																			---	---	---	---
GABBR1	2550	broad.mit.edu	37	6	29541927	29541928	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29541927_29541928insT	uc003nmp.3	-							NM_021903	NP_068703			gamma-aminobutyric acid (GABA) B receptor 1						gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)													---	---	---	---
ZFP57	346171	broad.mit.edu	37	6	29643130	29643130	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29643130delT	uc011dlw.1	-						ZFP57_uc003nnl.3_Intron	NM_001109809	NP_001103279			zinc finger protein 57 homolog						DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5																		---	---	---	---
HLA-G	3135	broad.mit.edu	37	6	29798581	29798582	+	3'UTR	INS	-	ATTTGTTCATGCCT	ATTTGTTCATGCCT	rs1704		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29798581_29798582insATTTGTTCATGCCT	uc003nnw.2	+	8					HLA-G_uc011dmb.1_Intron|HLA-G_uc003raj.3_3'UTR|HLA-G_uc003nnz.3_3'UTR|HLA-G_uc010jrn.2_3'UTR|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_Intron	NM_002127	NP_002118			major histocompatibility complex, class I, G						antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
BAT1	7919	broad.mit.edu	37	6	31500691	31500691	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31500691delG	uc003ntt.2	-						BAT1_uc003ntq.2_5'Flank|BAT1_uc003ntr.2_Frame_Shift_Del_p.Q52fs|BAT1_uc003nts.2_Intron|BAT1_uc011dnn.1_Intron|BAT1_uc003ntu.2_Intron|BAT1_uc003ntv.2_Intron	NM_004640	NP_004631			HLA-B associated transcript 1						intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0																		---	---	---	---
LSM2	57819	broad.mit.edu	37	6	31765430	31765430	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31765430delA	uc003nxg.2	-	5					VARS_uc003nxe.2_5'Flank|VARS_uc011doi.1_5'Flank	NM_021177	NP_067000			LSM2 homolog, U6 small nuclear RNA associated						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytosol|nucleoplasm	U6 snRNA binding				0																		---	---	---	---
SKIV2L	6499	broad.mit.edu	37	6	31931561	31931562	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31931561_31931562insT	uc003nyn.1	+						SKIV2L_uc011dou.1_Intron|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860			superkiller viralicidic activity 2-like homolog							nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4																		---	---	---	---
CYP21A2	1589	broad.mit.edu	37	6	32006625	32006625	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32006625delT	uc003nze.1	+						CYP21A2_uc003nzf.1_Intron	NM_000500	NP_000491			cytochrome P450, family 21, subfamily A,						glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|steroid 21-monooxygenase activity|steroid binding				0																		---	---	---	---
ATF6B	1388	broad.mit.edu	37	6	32095989	32095989	+	5'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32095989delC	uc003nzn.2	-	1					ATF6B_uc003nzo.2_5'UTR|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'UTR	NM_004381	NP_004372			activating transcription factor 6 beta isoform						response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
PRRT1	80863	broad.mit.edu	37	6	32119644	32119645	+	5'UTR	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32119644_32119645insG	uc003nzt.2	-	1					PRRT1_uc003nzs.2_5'UTR|PRRT1_uc003nzu.2_5'UTR|PPT2_uc003nzw.2_5'Flank|PPT2_uc003nzx.2_5'Flank|PPT2_uc011dpi.1_5'Flank|PPT2_uc003nzy.1_5'Flank|PPT2_uc003nzz.2_5'Flank|PPT2_uc003oaa.2_5'Flank|PPT2_uc010jtu.1_5'Flank	NM_030651	NP_085154			NG5 protein						response to biotic stimulus	integral to membrane				breast(1)	1																		---	---	---	---
PSMB8	5696	broad.mit.edu	37	6	32809249	32809249	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32809249delC	uc003oce.2	-						TAP2_uc011dqf.1_5'Flank|TAP2_uc003ocb.1_5'Flank|TAP2_uc003ocd.2_5'Flank|PSMB8_uc003ocf.2_Intron	NM_148919	NP_683720			proteasome beta 8 subunit isoform E2 proprotein						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			skin(1)	1																		---	---	---	---
HLA-DPB1	3115	broad.mit.edu	37	6	33048379	33048380	+	Intron	INS	-	GA	GA	rs3128959		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33048379_33048380insGA	uc003ocu.1	+						HLA-DPA1_uc003oct.1_Intron|HLA-DPB1_uc011dqn.1_Intron|HLA-DPB1_uc011dqo.1_Intron|HLA-DPB1_uc011dqp.1_Intron|HLA-DPB1_uc011dqq.1_5'Flank	NM_002121	NP_002112			major histocompatibility complex, class II, DP						antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				ovary(1)	1																		---	---	---	---
COL11A2	1302	broad.mit.edu	37	6	33153564	33153564	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33153564delG	uc003ocx.1	-						COL11A2_uc003ocy.1_Intron|COL11A2_uc003ocz.1_Intron	NM_080680	NP_542411			collagen, type XI, alpha 2 isoform 1						cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5																		---	---	---	---
KIFC1	3833	broad.mit.edu	37	6	33367780	33367780	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33367780delT	uc003oef.3	+						KIFC1_uc011drf.1_Intron|uc011drg.1_RNA	NM_002263	NP_002254			kinesin family member C1						blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0																		---	---	---	---
UHRF1BP1	54887	broad.mit.edu	37	6	34791317	34791320	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34791317_34791320delTTTT	uc003oju.3	+						UHRF1BP1_uc010jvm.1_Intron|UHRF1BP1_uc010jvn.2_Intron	NM_017754	NP_060224			ICBP90 binding protein 1											ovary(3)	3																		---	---	---	---
TAF11	6882	broad.mit.edu	37	6	34847943	34847943	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34847943delT	uc003ojw.1	-						UHRF1BP1_uc010jvm.1_Intron|TAF11_uc011dsr.1_Intron	NM_005643	NP_005634			TBP-associated factor 11						positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding				0																		---	---	---	---
PPARD	5467	broad.mit.edu	37	6	35389471	35389471	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35389471delA	uc003okm.2	+						PPARD_uc003okl.2_Intron|PPARD_uc003okn.2_Intron|PPARD_uc011dtb.1_Intron|PPARD_uc011dtc.1_Intron|PPARD_uc010jvv.1_Intron	NM_006238	NP_006229			peroxisome proliferative activated receptor,						apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)													---	---	---	---
TMEM217	221468	broad.mit.edu	37	6	37186119	37186119	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37186119delT	uc003onl.2	-						TMEM217_uc010jwr.2_Intron|TMEM217_uc010jws.2_Intron|TMEM217_uc003onm.3_3'UTR	NM_145316	NP_660359			transmembrane protein 217 isoform 1							integral to membrane					0																		---	---	---	---
FTSJD2	23070	broad.mit.edu	37	6	37420622	37420622	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37420622delT	uc003ons.2	+						FTSJD2_uc010jwu.2_Intron	NM_015050	NP_055865			FtsJ methyltransferase domain containing 2						mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5																		---	---	---	---
MDGA1	266727	broad.mit.edu	37	6	37612226	37612226	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:37612226delC	uc003onu.1	-						MDGA1_uc003onv.1_Intron	NM_153487	NP_705691			MAM domain containing						brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38759300	38759300	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38759300delT	uc003ooe.1	+							NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38899853	38899853	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38899853delA	uc003ooe.1	+						DNAH8_uc003oog.1_Intron|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
TREML3	340206	broad.mit.edu	37	6	41185829	41185829	+	5'Flank	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:41185829delT	uc003oqb.2	-							NR_027256				Homo sapiens TREM-like transcript 3 (TLT3) mRNA, partial cds.												0																		---	---	---	---
TAF8	129685	broad.mit.edu	37	6	42019374	42019375	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42019374_42019375delTT	uc003ors.2	+						CCND3_uc003orp.2_5'Flank|CCND3_uc011duk.1_5'Flank|CCND3_uc011dum.1_5'Flank|TAF8_uc003orr.2_Intron|TAF8_uc003ort.2_Intron|TAF8_uc003oru.1_Intron|TAF8_uc003orv.1_Intron|TAF8_uc011dun.1_Intron	NM_138572	NP_612639			TBP-associated factor 8						cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)															---	---	---	---
UBR2	23304	broad.mit.edu	37	6	42647373	42647373	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42647373delT	uc011dur.1	+						UBR2_uc011dus.1_Intron|UBR2_uc003osh.2_Intron|UBR2_uc011dut.1_Intron	NM_015255	NP_056070			ubiquitin protein ligase E3 component n-recognin						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)															---	---	---	---
C6orf153	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	-	-	rs3833662		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:42989414_42989419delGCCGGG	uc003otp.1	+	1	30_35	c.22_27delGCCGGG	c.(22-27)GCCGGGdel	p.AG14del		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	14_15					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)															---	---	---	---
CYP39A1	51302	broad.mit.edu	37	6	46607081	46607082	+	Intron	DEL	AT	-	-	rs138412044	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46607081_46607082delAT	uc003oyf.1	-						CYP39A1_uc011dwa.1_Intron|CYP39A1_uc010jzd.1_Intron	NM_016593	NP_057677			cytochrome P450, family 39, subfamily A,						bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(1)	1																		---	---	---	---
MUT	4594	broad.mit.edu	37	6	49412558	49412559	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49412558_49412559insT	uc003ozg.3	-							NM_000255	NP_000246			methylmalonyl Coenzyme A mutase precursor						fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
RHAG	6005	broad.mit.edu	37	6	49604650	49604650	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49604650delA	uc003ozk.3	-						RHAG_uc010jzl.2_5'Flank|RHAG_uc010jzm.2_5'Flank	NM_000324	NP_000315			Rh-associated glycoprotein						carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)																	---	---	---	---
CRISP3	10321	broad.mit.edu	37	6	49701364	49701364	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:49701364delT	uc003ozs.2	-							NM_006061	NP_006052			cysteine-rich secretory protein 3 precursor						innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)															---	---	---	---
TFAP2D	83741	broad.mit.edu	37	6	50713005	50713005	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50713005delT	uc003paf.2	+						TFAP2D_uc011dwt.1_Intron	NM_172238	NP_758438			transcription factor AP-2 beta-like 1								DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51483747	51483748	+	3'UTR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51483747_51483748insA	uc003pah.1	-	67						NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51921383	51921383	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51921383delT	uc003pah.1	-						PKHD1_uc003pai.2_Intron	NM_138694	NP_619639			fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
GSTA4	2941	broad.mit.edu	37	6	52843097	52843097	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:52843097delA	uc003pbc.2	-	6					GSTA4_uc003pbd.2_3'UTR|GSTA4_uc003pbe.2_3'UTR|GSTA4_uc003pbf.2_3'UTR	NM_001512	NP_001503			glutathione S-transferase alpha 4						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity				0	Lung NSC(77;0.103)				Glutathione(DB00143)													---	---	---	---
FAM83B	222584	broad.mit.edu	37	6	54791435	54791435	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:54791435delA	uc003pck.2	+							NM_001010872	NP_001010872			hypothetical protein LOC222584											ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)																	---	---	---	---
COL21A1	81578	broad.mit.edu	37	6	56047463	56047463	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56047463delA	uc003pcs.2	-						COL21A1_uc003pct.1_Intron|COL21A1_uc011dxi.1_Intron|COL21A1_uc003pcu.1_Intron	NM_030820	NP_110447			collagen, type XXI, alpha 1 precursor						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)															---	---	---	---
PRIM2	5558	broad.mit.edu	37	6	57183175	57183175	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57183175delT	uc003pdx.2	+						PRIM2_uc003pdv.1_Intron|PRIM2_uc003pdw.2_Intron	NM_000947	NP_000938			DNA primase polypeptide 2						DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	63170968	63170968	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:63170968delA								KHDRBS2 (174868 upstream) : LGSN (814889 downstream)																																			---	---	---	---
EYS	346007	broad.mit.edu	37	6	66112224	66112224	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:66112224delA	uc011dxu.1	-						EYS_uc003peq.2_Intron|EYS_uc003per.1_Intron	NM_001142800	NP_001136272			eyes shut homolog isoform 1						response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6																		---	---	---	---
RIMS1	22999	broad.mit.edu	37	6	72957623	72957624	+	Intron	INS	-	TTATGGTT	TTATGGTT			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72957623_72957624insTTATGGTT	uc003pga.2	+						RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804			regulating synaptic membrane exocytosis 1						calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)																---	---	---	---
RIMS1	22999	broad.mit.edu	37	6	72957700	72957700	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:72957700delT	uc003pga.2	+						RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_5'Flank|RIMS1_uc003pgg.2_5'Flank|RIMS1_uc003pgi.2_5'Flank|RIMS1_uc003pgh.2_5'Flank|RIMS1_uc003pgd.2_5'Flank|RIMS1_uc003pge.2_5'Flank|RIMS1_uc003pgb.3_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804			regulating synaptic membrane exocytosis 1						calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)																---	---	---	---
KCNQ5	56479	broad.mit.edu	37	6	73787656	73787656	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:73787656delT	uc003pgk.2	+						KCNQ5_uc003pgj.3_Intron|KCNQ5_uc011dyh.1_Intron|KCNQ5_uc011dyi.1_Intron|KCNQ5_uc010kat.2_Intron|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816			potassium voltage-gated channel, KQT-like						protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)														---	---	---	---
FILIP1	27145	broad.mit.edu	37	6	76029471	76029471	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76029471delG	uc003pia.2	-						FILIP1_uc003phy.1_Intron|FILIP1_uc003phz.2_Intron|FILIP1_uc010kbe.2_Intron|FILIP1_uc003pib.1_Intron	NM_015687	NP_056502			filamin A interacting protein 1											skin(3)|ovary(1)	4																		---	---	---	---
SENP6	26054	broad.mit.edu	37	6	76421202	76421202	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76421202delT	uc003pid.3	+						SENP6_uc003pie.3_Intron|SENP6_uc010kbf.2_Intron	NM_015571	NP_056386			SUMO1/sentrin specific peptidase 6 isoform 1						proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)																---	---	---	---
MYO6	4646	broad.mit.edu	37	6	76551241	76551244	+	Intron	DEL	AAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:76551241_76551244delAAAA	uc003pih.1	+						MYO6_uc003pig.1_Intron|MYO6_uc003pii.1_Intron	NM_004999	NP_004990			myosin VI						actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)														---	---	---	---
PHIP	55023	broad.mit.edu	37	6	79680410	79680410	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:79680410delA	uc003pir.2	-						PHIP_uc003piq.2_Intron|PHIP_uc011dyp.1_Intron	NM_017934	NP_060404			pleckstrin homology domain interacting protein						insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)														---	---	---	---
TTK	7272	broad.mit.edu	37	6	80720630	80720630	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80720630delA	uc003pjc.2	+	5	643	c.569delA	c.(568-570)CAAfs	p.Q190fs	TTK_uc003pjb.3_Frame_Shift_Del_p.Q190fs	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	190					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)														---	---	---	---
IBTK	25998	broad.mit.edu	37	6	82924634	82924634	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:82924634delT	uc003pjl.1	-						IBTK_uc011dyv.1_Intron|IBTK_uc011dyw.1_Intron|IBTK_uc010kbi.1_Intron|IBTK_uc003pjm.2_Intron	NM_015525	NP_056340			inhibitor of Bruton's tyrosine kinase						negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)														---	---	---	---
PGM3	5238	broad.mit.edu	37	6	83900377	83900377	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:83900377delA	uc003pjv.2	-						PGM3_uc003pjw.2_Intron|PGM3_uc011dyz.1_Intron|RWDD2A_uc003pjx.3_5'Flank|RWDD2A_uc011dza.1_5'Flank	NM_015599	NP_056414			phosphoglucomutase 3						dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)														---	---	---	---
SNAP91	9892	broad.mit.edu	37	6	84302279	84302279	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84302279delA	uc011dze.1	-						SNAP91_uc011dzd.1_Intron|SNAP91_uc003pkb.2_Intron|SNAP91_uc003pkc.2_Intron|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Intron	NM_014841	NP_055656			synaptosomal-associated protein, 91kDa homolog						clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)														---	---	---	---
SYNCRIP	10492	broad.mit.edu	37	6	86329254	86329255	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:86329254_86329255delAA	uc003pla.2	-						SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Intron	NM_006372	NP_006363			synaptotagmin binding, cytoplasmic RNA						CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)														---	---	---	---
ZNF292	23036	broad.mit.edu	37	6	87969484	87969484	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:87969484delA	uc003plm.3	+	8	6178	c.6137delA	c.(6136-6138)GAAfs	p.E2046fs		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	2046					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)														---	---	---	---
SLC35A1	10559	broad.mit.edu	37	6	88210866	88210866	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88210866delT	uc011dzj.1	+						SLC35A1_uc003plx.2_Intron|SLC35A1_uc010kbw.2_Intron|SLC35A1_uc003plz.2_Intron|SLC35A1_uc011dzi.1_Intron|SLC35A1_uc003ply.2_Intron|SLC35A1_uc010kbx.2_Intron|SLC35A1_uc010kby.2_Intron	NM_006416	NP_006407			solute carrier family 35 (CMP-sialic acid						carbohydrate metabolic process|protein modification process	Golgi membrane|integral to plasma membrane	CMP-N-acetylneuraminate transmembrane transporter activity|sugar:hydrogen symporter activity				0		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
RARS2	57038	broad.mit.edu	37	6	88258369	88258369	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88258369delA	uc003pme.2	-						RARS2_uc003pmb.2_Intron|RARS2_uc003pmc.2_Intron|RARS2_uc003pmd.2_Intron|RARS2_uc003pmf.2_Intron	NM_020320	NP_064716			arginyl-tRNA synthetase 2, mitochondrial						arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|central_nervous_system(1)	3		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)														---	---	---	---
SPACA1	81833	broad.mit.edu	37	6	88768360	88768360	+	Intron	DEL	A	-	-	rs77119212		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88768360delA	uc003pmn.2	+							NM_030960	NP_112222			sperm acrosome associated 1 precursor							integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)														---	---	---	---
RNGTT	8732	broad.mit.edu	37	6	89614294	89614295	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89614294_89614295delTT	uc003pmr.2	-						RNGTT_uc003pms.2_Intron|RNGTT_uc011dzu.1_Intron|RNGTT_uc003pmt.2_Intron	NM_003800	NP_003791			RNA guanylyltransferase and 5'-phosphatase						interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)														---	---	---	---
SFRS13B	135295	broad.mit.edu	37	6	89814773	89814773	+	Intron	DEL	A	-	-	rs35869140		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:89814773delA	uc003pmy.3	-							NM_080743	NP_542781			serine-arginine repressor protein						assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding				0																		---	---	---	---
MAP3K7	6885	broad.mit.edu	37	6	91226170	91226170	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:91226170delA	uc003pnz.1	-	17					MAP3K7_uc003pny.1_3'UTR|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003pob.1_3'UTR|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304			mitogen-activated protein kinase kinase kinase 7						activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)														---	---	---	---
KIAA0776	23376	broad.mit.edu	37	6	96974386	96974386	+	Intron	DEL	A	-	-	rs9320194	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:96974386delA	uc003por.2	+						KIAA0776_uc010kck.2_Intron	NM_015323	NP_056138			hypothetical protein LOC23376						negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97615908	97615908	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97615908delT	uc003ppb.2	-						C6orf167_uc011eaf.1_Intron	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
C6orf167	253714	broad.mit.edu	37	6	97730435	97730438	+	Intron	DEL	GGGG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:97730435_97730438delGGGG	uc003ppb.2	-						C6orf167_uc011eaf.1_5'Flank|C6orf167_uc010kcn.1_Intron|C6orf167_uc010kco.1_5'Flank|C6orf167_uc003ppc.2_5'Flank	NM_198468	NP_940870			hypothetical protein LOC253714						double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)														---	---	---	---
LIN28B	389421	broad.mit.edu	37	6	105474236	105474236	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105474236delA	uc003pqv.1	+	3	465	c.262delA	c.(262-264)AAAfs	p.K88fs	LIN28B_uc010kda.1_Frame_Shift_Del_p.K48fs	NM_001004317	NP_001004317	Q6ZN17	LN28B_HUMAN	lin-28 homolog B	88	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding				0		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)																---	---	---	---
PRDM1	639	broad.mit.edu	37	6	106547027	106547028	+	Intron	DEL	TA	-	-	rs115585312	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:106547027_106547028delTA	uc003prd.2	+						PRDM1_uc003pre.2_Intron	NM_001198	NP_001189			PR domain containing 1, with ZNF domain isoform						negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)				D|N|Mis|F|S		DLBCL								---	---	---	---
QRSL1	55278	broad.mit.edu	37	6	107090837	107090837	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:107090837delA	uc003prm.2	+						QRSL1_uc003prl.2_Intron	NM_018292	NP_060762			glutaminyl-tRNA synthase						translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	108325495	108325495	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:108325495delT								SEC63 (46013 upstream) : OSTM1 (37120 downstream)																																			---	---	---	---
ARMC2	84071	broad.mit.edu	37	6	109285993	109285993	+	Intron	DEL	A	-	-	rs77214837		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109285993delA	uc003pss.3	+						ARMC2_uc011eao.1_Intron	NM_032131	NP_115507			armadillo repeat containing 2								binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)														---	---	---	---
MICAL1	64780	broad.mit.edu	37	6	109769198	109769198	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:109769198delG	uc003ptj.2	-						MICAL1_uc003ptk.2_Intron|MICAL1_uc010kdr.2_Intron|MICAL1_uc011eaq.1_Intron	NM_022765	NP_073602			microtubule associated monoxygenase, calponin						cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)														---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110426584	110426584	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110426584delA	uc003ptv.1	-						WASF1_uc003ptw.1_Intron|WASF1_uc003ptx.1_Intron|WASF1_uc003pty.1_Intron	NM_003931	NP_003922			Wiskott-Aldrich syndrome protein family member						actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
CDC40	51362	broad.mit.edu	37	6	110528894	110528894	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110528894delT	uc003pua.2	+							NM_015891	NP_056975			cell division cycle 40 homolog						mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm					0		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)														---	---	---	---
CDK19	23097	broad.mit.edu	37	6	110942585	110942585	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110942585delA	uc003puh.1	-						CDK19_uc003pui.1_Intron|CDK19_uc011eax.1_Intron	NM_015076	NP_055891			cell division cycle 2-like 6 (CDK8-like)								ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
AMD1	262	broad.mit.edu	37	6	111185169	111185169	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111185169delT	uc011eay.1	+							NM_001033059	NP_001028231			adenosylmethionine decarboxylase 1 isoform 2						spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)													---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111696108	111696108	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111696108delA	uc003puy.3	-	13	3773	c.3450delT	c.(3448-3450)TTTfs	p.F1150fs	REV3L_uc003pux.3_Frame_Shift_Del_p.F1072fs|REV3L_uc003puz.3_Frame_Shift_Del_p.F1072fs	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1150					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
REV3L	5980	broad.mit.edu	37	6	111714246	111714246	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111714246delT	uc003puy.3	-						REV3L_uc003pux.3_Intron|REV3L_uc003puz.3_Intron	NM_002912	NP_002903			DNA polymerase zeta						DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
FYN	2534	broad.mit.edu	37	6	111995653	111995654	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:111995653_111995654insA	uc003pvj.2	-						FYN_uc003pvi.2_Intron|FYN_uc003pvk.2_Intron|FYN_uc003pvh.2_Intron	NM_002037	NP_002028			protein-tyrosine kinase fyn isoform a						axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)													---	---	---	---
FRK	2444	broad.mit.edu	37	6	116325059	116325059	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116325059delT	uc003pwi.1	-	2	894	c.447delA	c.(445-447)AAAfs	p.K149fs		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	149	SH2.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)														---	---	---	---
NT5DC1	221294	broad.mit.edu	37	6	116560061	116560061	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116560061delT	uc003pwj.2	+						NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_152729	NP_689942			5'-nucleotidase, cytosolic II-like 1 protein								hydrolase activity|metal ion binding				0		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)														---	---	---	---
MCM9	254394	broad.mit.edu	37	6	119245399	119245399	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:119245399delA	uc003pyh.2	-							NM_153255	NP_694987			minichromosome maintenance complex component 9						DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)														---	---	---	---
C6orf170	221322	broad.mit.edu	37	6	121576559	121576559	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121576559delA	uc003pyo.1	-						C6orf170_uc003pyq.1_Intron|C6orf170_uc003pyp.1_Intron	NM_152730	NP_689943			hypothetical protein LOC221322						multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)														---	---	---	---
C6orf170	221322	broad.mit.edu	37	6	121629254	121629254	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:121629254delT	uc003pyo.1	-						C6orf170_uc003pyq.1_Intron	NM_152730	NP_689943			hypothetical protein LOC221322						multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)														---	---	---	---
HSF2	3298	broad.mit.edu	37	6	122733681	122733681	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:122733681delT	uc003pyu.2	+						HSF2_uc003pyt.3_Intron|HSF2_uc003pyv.2_Intron	NM_004506	NP_004497			heat shock transcription factor 2 isoform a						response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)														---	---	---	---
TRDN	10345	broad.mit.edu	37	6	123786033	123786033	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:123786033delA	uc003pzj.1	-						TRDN_uc003pzk.1_Intron|TRDN_uc003pzl.1_Intron|TRDN_uc010ken.2_Frame_Shift_Del_p.S297fs|uc003pzm.1_Intron	NM_006073	NP_006064			triadin						muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)														---	---	---	---
TRDN	10345	broad.mit.edu	37	6	123786155	123786155	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:123786155delA	uc003pzj.1	-						TRDN_uc003pzk.1_Intron|TRDN_uc003pzl.1_Intron|TRDN_uc010ken.2_Intron|uc003pzm.1_Intron	NM_006073	NP_006064			triadin						muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)														---	---	---	---
TPD52L1	7164	broad.mit.edu	37	6	125550520	125550520	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:125550520delA	uc003pzu.1	+						TPD52L1_uc003pzv.1_Intron|TPD52L1_uc003pzw.1_Intron|TPD52L1_uc003pzx.1_Intron|TPD52L1_uc003pzy.1_Intron|TPD52L1_uc003pzz.1_Intron	NM_003287	NP_003278			tumor protein D52-like 1 isoform 1						DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)														---	---	---	---
C6orf174	387104	broad.mit.edu	37	6	127771252	127771252	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:127771252delT	uc003qbd.2	-	9					C6orf174_uc003qbc.2_Frame_Shift_Del_p.K127fs|C6orf174_uc003qbb.2_Frame_Shift_Del_p.K10fs|KIAA0408_uc011ebs.1_Frame_Shift_Del_p.K127fs	NM_001012279	NP_001012279			hypothetical protein LOC387104 precursor							integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)														---	---	---	---
PTPRK	5796	broad.mit.edu	37	6	128321487	128321487	+	Intron	DEL	A	-	-	rs113113294		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128321487delA	uc003qbk.2	-						PTPRK_uc003qbj.2_Intron|PTPRK_uc010kfc.2_Intron|PTPRK_uc011ebu.1_Intron|PTPRK_uc003qbl.1_Intron|PTPRK_uc011ebv.1_Intron|PTPRK_uc010kfd.1_Intron	NM_002844	NP_002835			protein tyrosine phosphatase, receptor type, K						cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129475558	129475559	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129475558_129475559insA	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417			laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
LAMA2	3908	broad.mit.edu	37	6	129759768	129759768	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:129759768delT	uc003qbn.2	+						LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417			laminin alpha 2 subunit isoform a precursor						cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)														---	---	---	---
SAMD3	154075	broad.mit.edu	37	6	130535448	130535448	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:130535448delA	uc003qbv.2	-						SAMD3_uc003qbx.2_Intron|SAMD3_uc003qbw.2_Intron|SAMD3_uc010kfg.1_Intron|SAMD3_uc003qby.2_Intron|SAMD3_uc003qbz.1_Intron	NM_001017373	NP_001017373			sterile alpha motif domain containing 3 isoform											ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131247860	131247862	+	Intron	DEL	AAT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131247860_131247862delAAT	uc003qch.2	-						EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron	NM_001431	NP_001422			erythrocyte membrane protein band 4.1-like 2						cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)														---	---	---	---
AKAP7	9465	broad.mit.edu	37	6	131481276	131481276	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131481276delA	uc003qck.2	+	3	262	c.229delA	c.(229-231)AAAfs	p.K77fs	AKAP7_uc011ebz.1_Frame_Shift_Del_p.K55fs	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)														---	---	---	---
AKAP7	9465	broad.mit.edu	37	6	131520530	131520530	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131520530delT	uc003qck.2	+						AKAP7_uc011ebz.1_Intron|AKAP7_uc003qcl.1_Intron	NM_016377	NP_057461			A-kinase anchor protein 7 isoform gamma						intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)														---	---	---	---
MED23	9439	broad.mit.edu	37	6	131917389	131917389	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131917389delT	uc003qcs.1	-						MED23_uc003qcq.2_Intron|MED23_uc011eca.1_Intron	NM_004830	NP_004821			mediator complex subunit 23 isoform a						regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)														---	---	---	---
SLC2A12	154091	broad.mit.edu	37	6	134349584	134349584	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:134349584delA	uc003qem.1	-	2	1550	c.1379delT	c.(1378-1380)TTGfs	p.L460fs		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	460	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)														---	---	---	---
HBS1L	10767	broad.mit.edu	37	6	135290483	135290484	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135290483_135290484insA	uc003qez.2	-						HBS1L_uc003qey.2_Intron|HBS1L_uc011ecy.1_Intron|HBS1L_uc011ecz.1_Intron|HBS1L_uc011eda.1_Intron	NM_006620	NP_006611			Hsp70 subfamily B suppressor 1-like protein						signal transduction		GTP binding|GTPase activity|translation elongation factor activity			skin(2)	2	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)														---	---	---	---
AHI1	54806	broad.mit.edu	37	6	135777071	135777071	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135777071delA	uc003qgi.2	-						AHI1_uc003qgh.2_Intron|AHI1_uc003qgj.2_Intron|AHI1_uc003qgk.3_Intron|AHI1_uc003qgl.3_Intron	NM_001134831	NP_001128303			Abelson helper integration site 1 isoform a							adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)														---	---	---	---
AHI1	54806	broad.mit.edu	37	6	135784283	135784284	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:135784283_135784284insT	uc003qgi.2	-	8	1294_1295	c.910_911insA	c.(910-912)ACAfs	p.T304fs	AHI1_uc003qgh.2_Frame_Shift_Ins_p.T304fs|AHI1_uc003qgj.2_Frame_Shift_Ins_p.T304fs|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Frame_Shift_Ins_p.T304fs	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	304						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)														---	---	---	---
Unknown	0	broad.mit.edu	37	6	137865376	137865377	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:137865376_137865377insT								OLIG3 (49845 upstream) : TNFAIP3 (323204 downstream)																																			---	---	---	---
GPR126	57211	broad.mit.edu	37	6	142737280	142737280	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:142737280delA	uc010khc.2	+						GPR126_uc010khd.2_Intron|GPR126_uc010khe.2_Intron|GPR126_uc010khf.2_Intron	NM_020455	NP_065188			G protein-coupled receptor 126 alpha 1						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)														---	---	---	---
HIVEP2	3097	broad.mit.edu	37	6	143090598	143090598	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143090598delT	uc003qjd.2	-							NM_006734	NP_006725			human immunodeficiency virus type I enhancer						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)														---	---	---	---
PHACTR2	9749	broad.mit.edu	37	6	144109889	144109889	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144109889delT	uc003qjq.3	+						PHACTR2_uc010khh.2_Intron|PHACTR2_uc010khi.2_Intron|PHACTR2_uc003qjr.3_Intron	NM_014721	NP_055536			phosphatase and actin regulator 2 isoform 3								actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)														---	---	---	---
LTV1	84946	broad.mit.edu	37	6	144179191	144179191	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144179191delT	uc003qjs.2	+						LTV1_uc003qju.1_Intron|C6orf94_uc010khj.2_Intron	NM_032860	NP_116249			LTV1 homolog											ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)														---	---	---	---
SHPRH	257218	broad.mit.edu	37	6	146244956	146244956	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146244956delT	uc003qlf.2	-						SHPRH_uc003qld.2_Intron|SHPRH_uc003qle.2_Intron|SHPRH_uc003qlg.1_Intron|SHPRH_uc003qlh.2_Intron|SHPRH_uc003qli.1_Intron	NM_001042683	NP_001036148			SNF2 histone linker PHD RING helicase isoform a						DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)														---	---	---	---
PPIL4	85313	broad.mit.edu	37	6	149838604	149838604	+	Intron	DEL	A	-	-	rs144110636		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149838604delA	uc003qmo.1	-						PPIL4_uc010kic.2_Intron|PPIL4_uc003qmp.1_Intron	NM_139126	NP_624311			peptidylprolyl isomerase-like 4						protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)														---	---	---	---
PCMT1	5110	broad.mit.edu	37	6	150114900	150114901	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150114900_150114901delTT	uc003qne.2	+						PCMT1_uc003qna.2_Intron|PCMT1_uc003qnb.2_Intron|PCMT1_uc011eeg.1_Intron|PCMT1_uc003qnc.2_Intron|PCMT1_uc003qnd.2_Intron|PCMT1_uc003qnf.2_Intron	NM_005389	NP_005380			protein-L-isoaspartate (D-aspartate)											ovary(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.221)	OV - Ovarian serous cystadenocarcinoma(155;5.63e-13)|GBM - Glioblastoma multiforme(68;0.207)														---	---	---	---
ESR1	2099	broad.mit.edu	37	6	152163717	152163717	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152163717delT	uc003qom.3	+						ESR1_uc010kin.2_Intron|ESR1_uc010kio.2_Intron|ESR1_uc010kip.2_Intron|ESR1_uc003qon.3_Intron|ESR1_uc003qoo.3_Intron|ESR1_uc010kiq.2_Intron|ESR1_uc010kir.2_Intron|ESR1_uc011eet.1_5'Flank|ESR1_uc011eeu.1_5'Flank|ESR1_uc011eev.1_5'Flank|ESR1_uc011eew.1_5'Flank	NM_001122742	NP_001116214			estrogen receptor alpha isoform 4						positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			central_nervous_system(2)|ovary(1)|lung(1)|breast(1)	5		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)													---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152647065	152647065	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152647065delT	uc010kiw.2	-						SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Intron|SYNE1_uc010kiz.2_Intron	NM_182961	NP_892006			spectrin repeat containing, nuclear envelope 1						cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
NOX3	50508	broad.mit.edu	37	6	155749721	155749723	+	Intron	DEL	TTT	-	-	rs111606766		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155749721_155749723delTTT	uc003qqm.2	-							NM_015718	NP_056533			NADPH oxidase 3								electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)														---	---	---	---
NOX3	50508	broad.mit.edu	37	6	155757642	155757643	+	Frame_Shift_Ins	INS	-	AG	AG			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155757642_155757643insAG	uc003qqm.2	-	7	810_811	c.707_708insCT	c.(706-708)CTGfs	p.L236fs		NM_015718	NP_056533	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	236	Extracellular (Potential).|Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)														---	---	---	---
NOX3	50508	broad.mit.edu	37	6	155761344	155761344	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155761344delT	uc003qqm.2	-							NM_015718	NP_056533			NADPH oxidase 3								electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			ovary(1)	1		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)														---	---	---	---
SERAC1	84947	broad.mit.edu	37	6	158537100	158537100	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158537100delG	uc003qrc.2	-						SERAC1_uc003qrb.2_Intron	NM_032861	NP_116250			serine active site containing 1						GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160465465	160465465	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160465465delT	uc003qta.2	+							NM_000876	NP_000867			insulin-like growth factor 2 receptor precursor						receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
MAP3K4	4216	broad.mit.edu	37	6	161491963	161491963	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161491963delT	uc003qtn.2	+						MAP3K4_uc010kkc.1_Intron|MAP3K4_uc003qto.2_Intron|MAP3K4_uc011efz.1_Intron|MAP3K4_uc011ega.1_Intron	NM_005922	NP_005913			mitogen-activated protein kinase kinase kinase 4						activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)														---	---	---	---
MAP3K4	4216	broad.mit.edu	37	6	161536147	161536147	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161536147delT	uc003qtn.2	+						MAP3K4_uc003qto.2_Intron|MAP3K4_uc011efz.1_Intron|MAP3K4_uc011ega.1_Intron|MAP3K4_uc003qtp.2_Intron|MAP3K4_uc003qtq.2_Intron	NM_005922	NP_005913			mitogen-activated protein kinase kinase kinase 4						activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)														---	---	---	---
QKI	9444	broad.mit.edu	37	6	163899920	163899920	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:163899920delA	uc003qui.2	+	3	945	c.394delA	c.(394-396)AAAfs	p.K132fs	QKI_uc003que.2_Frame_Shift_Del_p.K132fs|QKI_uc003quf.2_Frame_Shift_Del_p.K132fs|QKI_uc003qug.2_Frame_Shift_Del_p.K132fs|QKI_uc003quh.2_Frame_Shift_Del_p.K132fs|QKI_uc003quj.2_Frame_Shift_Del_p.K132fs	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	132	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)														---	---	---	---
QKI	9444	broad.mit.edu	37	6	163991599	163991599	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:163991599delT	uc003qui.2	+						QKI_uc003quj.2_Intron	NM_006775	NP_006766			quaking homolog, KH domain RNA binding isoform						mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)														---	---	---	---
FGFR1OP	11116	broad.mit.edu	37	6	167447338	167447338	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:167447338delT	uc003qvj.2	+						CCR6_uc003qvl.2_Intron|FGFR1OP_uc011egp.1_Intron|FGFR1OP_uc003qvk.2_Intron	NM_007045	NP_008976			FGFR1 oncogene partner isoform a						G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)				T	FGFR1	MPD|NHL								---	---	---	---
C6orf70	55780	broad.mit.edu	37	6	170181412	170181412	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170181412delT	uc003qxg.1	+						C6orf70_uc011ehb.1_Intron|C6orf70_uc003qxh.1_Intron|C6orf70_uc010kky.1_Intron|C6orf70_uc003qxi.1_Intron	NM_018341	NP_060811			hypothetical protein LOC55780							integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)														---	---	---	---
PDCD2	5134	broad.mit.edu	37	6	170892854	170892855	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:170892854_170892855delAA	uc003qxw.2	-						PDCD2_uc003qxv.2_Intron|PDCD2_uc003qxx.1_Intron|PDCD2_uc003qxy.2_Intron|PDCD2_uc003qxz.2_Intron|PDCD2_uc003qya.2_Intron|PDCD2_uc003qyb.1_Intron	NM_002598	NP_002589			programmed cell death 2 isoform 1						apoptosis	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding				0		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|BRCA - Breast invasive adenocarcinoma(81;4.82e-06)|GBM - Glioblastoma multiforme(31;0.142)														---	---	---	---
C7orf50	84310	broad.mit.edu	37	7	1167118	1167118	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1167118delA	uc003sju.2	-						C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron	NM_032350	NP_115726			hypothetical protein LOC84310								protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)														---	---	---	---
MAD1L1	8379	broad.mit.edu	37	7	2020236	2020271	+	Intron	DEL	ACCCCAGCCCAGGCCCCTGAGACCACCCCTGGCAGC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:2020236_2020271delACCCCAGCCCAGGCCCCTGAGACCACCCCTGGCAGC	uc003slh.1	-						MAD1L1_uc003sle.1_Intron|MAD1L1_uc003slf.1_Intron|MAD1L1_uc003slg.1_Intron|MAD1L1_uc010ksh.1_Intron|MAD1L1_uc003sli.1_Intron|MAD1L1_uc010ksi.1_Intron|MAD1L1_uc010ksj.2_Intron	NM_001013836	NP_001013858			MAD1-like 1 protein						cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)														---	---	---	---
RNF216	54476	broad.mit.edu	37	7	5780522	5780522	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5780522delT	uc003soy.1	-						RNF216_uc010ksz.1_Intron|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Intron	NM_207116	NP_996999			ring finger protein 216 isoform b						apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)														---	---	---	---
EIF2AK1	27102	broad.mit.edu	37	7	6089528	6089528	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6089528delT	uc003spp.2	-						EIF2AK1_uc003spq.2_Intron|EIF2AK1_uc011jwm.1_Intron	NM_014413	NP_055228			eukaryotic translation initiation factor 2-alpha						negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)														---	---	---	---
USP42	84132	broad.mit.edu	37	7	6196576	6196577	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6196576_6196577delCT	uc011jwo.1	+	16	3956_3957	c.3833_3834delCT	c.(3832-3834)CCTfs	p.P1278fs	USP42_uc011jwp.1_Frame_Shift_Del_p.P1278fs|USP42_uc011jwq.1_Frame_Shift_Del_p.P1085fs	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	1278					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)														---	---	---	---
RAC1	5879	broad.mit.edu	37	7	6439959	6439959	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6439959delT	uc003spx.2	+						RAC1_uc003spw.2_Intron	NM_006908	NP_008839			ras-related C3 botulinum toxin substrate 1						actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)													---	---	---	---
COL28A1	340267	broad.mit.edu	37	7	7516924	7516924	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7516924delA	uc003src.1	-						COL28A1_uc011jxe.1_Intron|COL28A1_uc003srd.2_Intron	NM_001037763	NP_001032852			collagen, type XXVIII precursor						cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)														---	---	---	---
MIOS	54468	broad.mit.edu	37	7	7625576	7625576	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:7625576delT	uc003srf.2	+						MIOS_uc003srg.2_Intron|MIOS_uc010ktq.2_Intron	NM_019005	NP_061878			missing oocyte, meiosis regulator, homolog												0																		---	---	---	---
GLCCI1	113263	broad.mit.edu	37	7	8043518	8043518	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8043518delT	uc003srk.2	+							NM_138426	NP_612435			glucocorticoid induced transcript 1												0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)														---	---	---	---
ICA1	3382	broad.mit.edu	37	7	8183660	8183660	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8183660delA	uc003srm.2	-						ICA1_uc010ktr.2_Intron|ICA1_uc003srl.2_Intron|ICA1_uc003srn.3_Intron|ICA1_uc003srp.3_Intron|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Intron|ICA1_uc003srr.2_Intron|ICA1_uc003sro.3_Intron	NM_022307	NP_071682			islet cell autoantigen 1						neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)														---	---	---	---
NXPH1	30010	broad.mit.edu	37	7	8651853	8651853	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:8651853delT	uc003srv.2	+						NXPH1_uc011jxh.1_Intron	NM_152745	NP_689958			neurexophilin 1 precursor							extracellular region				ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)														---	---	---	---
NDUFA4	4697	broad.mit.edu	37	7	10978274	10978274	+	Intron	DEL	A	-	-	rs10272132	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:10978274delA	uc003srx.1	-							NM_002489	NP_002480			NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)													---	---	---	---
PHF14	9678	broad.mit.edu	37	7	11021973	11021973	+	Intron	DEL	T	-	-	rs79565747		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11021973delT	uc003sry.1	+						PHF14_uc011jxi.1_Intron|PHF14_uc003srz.2_Intron|PHF14_uc011jxj.1_Intron	NM_014660	NP_055475			PHD finger protein 14 isoform 2								zinc ion binding			kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)														---	---	---	---
SCIN	85477	broad.mit.edu	37	7	12664852	12664852	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:12664852delA	uc003ssn.3	+						SCIN_uc010ktt.2_Intron|SCIN_uc003sso.3_Intron	NM_001112706	NP_001106177			scinderin isoform 1						actin filament capping|actin filament severing|actin nucleation|calcium ion-dependent exocytosis|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of megakaryocyte differentiation|positive regulation of secretion|regulation of chondrocyte differentiation	cell cortex|cytoskeleton	1-phosphatidylinositol binding|actin filament binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding			ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.195)														---	---	---	---
TMEM195	392636	broad.mit.edu	37	7	15458294	15458294	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:15458294delA	uc003stb.1	-							NM_001004320	NP_001004320			transmembrane protein 195						ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0																		---	---	---	---
MACC1	346389	broad.mit.edu	37	7	20180843	20180844	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20180843_20180844insA	uc003sus.3	-						MACC1_uc010kug.2_Intron	NM_182762	NP_877439			putative binding protein 7a5						positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3																		---	---	---	---
SP8	221833	broad.mit.edu	37	7	20826480	20826480	+	5'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20826480delT	uc003suy.2	-	1					SP8_uc003suz.2_5'UTR	NM_198956	NP_945194			Sp8 transcription factor isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	20867445	20867445	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:20867445delA								RPL23P8 (6 upstream) : SP4 (600244 downstream)																																			---	---	---	---
SP4	6671	broad.mit.edu	37	7	21510544	21510544	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:21510544delA	uc003sva.2	+						SP4_uc003svb.2_Intron|MIR1183_hsa-mir-1183|MI0006276_5'Flank	NM_003112	NP_003103			Sp4 transcription factor						regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5																		---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22330863	22330865	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22330863_22330865delAAA	uc003svg.2	-							NM_012294	NP_036426			Rap guanine nucleotide exchange factor (GEF) 5						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
RAPGEF5	9771	broad.mit.edu	37	7	22349768	22349769	+	Intron	DEL	AC	-	-	rs55757213	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:22349768_22349769delAC	uc003svg.2	-							NM_012294	NP_036426			Rap guanine nucleotide exchange factor (GEF) 5						nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
TRA2A	29896	broad.mit.edu	37	7	23552393	23552394	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23552393_23552394delAA	uc003swi.2	-						TRA2A_uc011jzb.1_Intron|TRA2A_uc011jzc.1_Intron|TRA2A_uc011jzd.1_Intron	NM_013293	NP_037425			transformer-2 alpha						nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1																		---	---	---	---
C7orf46	340277	broad.mit.edu	37	7	23741877	23741877	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:23741877delT	uc003swo.3	+	7					C7orf46_uc003swq.3_3'UTR|C7orf46_uc003swr.3_3'UTR|C7orf46_uc003swp.3_RNA|C7orf46_uc010kup.2_RNA	NM_199136	NP_954587			hypothetical protein LOC340277 isoform 1												0																		---	---	---	---
HNRNPA2B1	3181	broad.mit.edu	37	7	26237494	26237495	+	Intron	DEL	GA	-	-	rs57800062		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:26237494_26237495delGA	uc003sxr.3	-						HNRNPA2B1_uc003sxs.3_Intron	NM_031243	NP_112533			heterogeneous nuclear ribonucleoprotein A2/B1						RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3								T	ETV1	prostate								---	---	---	---
Unknown	0	broad.mit.edu	37	7	26316251	26316251	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:26316251delA								CBX3 (63277 upstream) : SNX10 (15264 downstream)																																			---	---	---	---
HOXA3	3200	broad.mit.edu	37	7	27147495	27147495	+	3'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27147495delG	uc011jzl.1	-	3					HOXA3_uc011jzk.1_3'UTR|HOXA3_uc003syk.2_3'UTR	NM_030661	NP_109377			homeobox A3 isoform a						angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2																		---	---	---	---
HIBADH	11112	broad.mit.edu	37	7	27689339	27689339	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:27689339delT	uc003szf.2	-						HIBADH_uc003szg.2_Intron|HIBADH_uc003szh.2_Intron|HIBADH_uc003szi.2_5'Flank	NM_152740	NP_689953			3-hydroxyisobutyrate dehydrogenase precursor						branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)													---	---	---	---
CREB5	9586	broad.mit.edu	37	7	28547488	28547489	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:28547488_28547489insT	uc003szq.2	+						CREB5_uc003szo.2_Intron|CREB5_uc003szr.2_Intron	NM_182898	NP_878901			cAMP responsive element binding protein 5						positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2																		---	---	---	---
CPVL	54504	broad.mit.edu	37	7	29152222	29152222	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:29152222delT	uc003szv.2	-						CPVL_uc003szw.2_Intron|CPVL_uc003szx.2_Intron	NM_031311	NP_112601			serine carboxypeptidase vitellogenic-like						proteolysis		protein binding|serine-type carboxypeptidase activity			ovary(2)	2																		---	---	---	---
PLEKHA8	84725	broad.mit.edu	37	7	30113605	30113606	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30113605_30113606delAA	uc003tam.1	+						PLEKHA8_uc003tao.2_Intron|PLEKHA8_uc003tap.1_Intron|PLEKHA8_uc003tan.2_Intron	NM_032639	NP_116028			pleckstrin homology domain containing, family A						protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4																		---	---	---	---
CRHR2	1395	broad.mit.edu	37	7	30694783	30694783	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:30694783delG	uc003tbn.2	-						CRHR2_uc010kvw.1_Intron|CRHR2_uc010kvx.1_Intron|CRHR2_uc010kvy.1_Intron|CRHR2_uc003tbo.2_Intron|CRHR2_uc003tbp.2_Intron	NM_001883	NP_001874			corticotropin releasing hormone receptor 2						G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	31404676	31404677	+	IGR	DEL	AA	-	-	rs35317967		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31404676_31404677delAA								NEUROD6 (24138 upstream) : CCDC129 (149008 downstream)																																			---	---	---	---
RP9	6100	broad.mit.edu	37	7	33136257	33136257	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:33136257delT	uc003tdm.2	-							NM_203288	NP_976033			retinitis pigmentosa 9						RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)															---	---	---	---
DPY19L2P1	554236	broad.mit.edu	37	7	35204644	35204645	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:35204644_35204645insA	uc003teq.1	-						DPY19L2P1_uc010kwz.1_5'Flank					RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
ANLN	54443	broad.mit.edu	37	7	36447172	36447172	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:36447172delT	uc003tff.2	+						ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Intron|ANLN_uc010kxe.2_Intron	NM_018685	NP_061155			anillin, actin binding protein						cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3																		---	---	---	---
POU6F2	11281	broad.mit.edu	37	7	39246850	39246850	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:39246850delT	uc003thb.1	+						POU6F2_uc010kxo.2_Intron	NM_007252	NP_009183			POU class 6 homeobox 2 isoform 1						central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1																		---	---	---	---
CDK13	8621	broad.mit.edu	37	7	40027894	40027895	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40027894_40027895insA	uc003thh.3	+						CDK13_uc003thi.3_Intron|CDK13_uc011kbf.1_Intron	NM_003718	NP_003709			cell division cycle 2-like 5 isoform 1						alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5																		---	---	---	---
C7orf10	79783	broad.mit.edu	37	7	40192303	40192306	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40192303_40192306delTTTT	uc003thn.1	+						C7orf10_uc003thm.1_Intron|C7orf10_uc003tho.1_Intron	NM_024728	NP_079004			dermal papilla derived protein 13								transferase activity			ovary(2)	2																		---	---	---	---
C7orf10	79783	broad.mit.edu	37	7	40220725	40220725	+	Intron	DEL	G	-	-	rs58068135	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:40220725delG	uc003thn.1	+						C7orf10_uc003thm.1_Intron|C7orf10_uc003tho.1_Intron	NM_024728	NP_079004			dermal papilla derived protein 13								transferase activity			ovary(2)	2																		---	---	---	---
C7orf25	79020	broad.mit.edu	37	7	42966271	42966271	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:42966271delA	uc010kxr.2	-						PSMA2_uc003thy.2_Intron|PSMA2_uc010kxt.2_Intron|PSMA2_uc003thz.1_Intron	NM_001099858	NP_001093328			hypothetical protein LOC79020 a											skin(1)	1																		---	---	---	---
BLVRA	644	broad.mit.edu	37	7	43840038	43840038	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:43840038delT	uc003tir.2	+						BLVRA_uc010kxv.2_Intron	NM_000712	NP_000703			biliverdin reductase A precursor						heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			ovary(1)	1					NADH(DB00157)													---	---	---	---
POLM	27434	broad.mit.edu	37	7	44120414	44120414	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44120414delG	uc003tjt.2	-	2	382	c.290delC	c.(289-291)CCAfs	p.P97fs	POLM_uc003tju.2_Frame_Shift_Del_p.P97fs|POLM_uc003tjx.2_Frame_Shift_Del_p.P97fs|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_5'UTR|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Frame_Shift_Del_p.P97fs|POLM_uc011kbu.1_Frame_Shift_Del_p.P97fs|POLM_uc010kxy.2_Frame_Shift_Del_p.P97fs	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	97	BRCT.				DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3													DNA_polymerases_(catalytic_subunits)					---	---	---	---
ZMIZ2	83637	broad.mit.edu	37	7	44796429	44796429	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44796429delC	uc003tlr.2	+						ZMIZ2_uc003tlq.2_Intron|ZMIZ2_uc003tls.2_Intron|ZMIZ2_uc003tlt.2_5'Flank|ZMIZ2_uc010kyj.2_5'Flank	NM_031449	NP_113637			zinc finger, MIZ-type containing 2 isoform 1						positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5																		---	---	---	---
TNS3	64759	broad.mit.edu	37	7	47440219	47440219	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47440219delT	uc003tnv.2	-						TNS3_uc003tnw.2_Intron	NM_022748	NP_073585			tensin 3							focal adhesion	protein binding			ovary(4)	4																		---	---	---	---
PKD1L1	168507	broad.mit.edu	37	7	47857468	47857468	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:47857468delA	uc003tny.1	-						C7orf69_uc003tnz.3_Intron|C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_Intron	NM_138295	NP_612152			polycystin-1L1						cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11																		---	---	---	---
UPP1	7378	broad.mit.edu	37	7	48142767	48142767	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48142767delA	uc003toj.2	+						UPP1_uc003tok.2_Intron|UPP1_uc003tol.2_Intron|UPP1_uc011kcg.1_Intron|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628			uridine phosphorylase 1						nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0																		---	---	---	---
ABCA13	154664	broad.mit.edu	37	7	48511119	48511119	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:48511119delT	uc003toq.2	+						ABCA13_uc010kys.1_Intron|ABCA13_uc010kyt.1_Intron|ABCA13_uc010kyu.1_Intron	NM_152701	NP_689914			ATP binding cassette, sub-family A (ABC1),						transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	50911447	50911447	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50911447delC								GRB10 (50288 upstream) : COBL (172463 downstream)																																			---	---	---	---
EGFR	1956	broad.mit.edu	37	7	55269063	55269064	+	Intron	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55269063_55269064delTC	uc003tqk.2	+						EGFR_uc010kzg.1_Intron|EGFR_uc011kco.1_Intron	NM_005228	NP_005219			epidermal growth factor receptor isoform a						activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---	---
SEPT14	346288	broad.mit.edu	37	7	55872770	55872770	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55872770delA	uc003tqz.2	-							NM_207366	NP_997249			septin 14						cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)															---	---	---	---
Unknown	0	broad.mit.edu	37	7	56357563	56357573	+	IGR	DEL	AAAAAAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:56357563_56357573delAAAAAAAAAAA								PSPH (173473 upstream) : DKFZp434L192 (206343 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	57216044	57216044	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:57216044delT								ZNF479 (8473 upstream) : ZNF716 (293839 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	57218127	57218128	+	IGR	DEL	GA	-	-	rs13228137	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:57218127_57218128delGA								ZNF479 (10556 upstream) : ZNF716 (291755 downstream)																																			---	---	---	---
ZNF735	730291	broad.mit.edu	37	7	63674626	63674627	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:63674626_63674627insT	uc011kdn.1	+							NM_001159524	NP_001152996			zinc finger protein 735						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF107	51427	broad.mit.edu	37	7	64152468	64152468	+	Intron	DEL	T	-	-	rs35690123	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64152468delT	uc003ttd.2	+						ZNF107_uc003tte.2_Intron	NM_016220	NP_057304			zinc finger protein 107						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)																---	---	---	---
Unknown	0	broad.mit.edu	37	7	64728451	64728451	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:64728451delA								INTS4L1 (33852 upstream) : ZNF92 (110317 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	7	65222951	65222951	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:65222951delT	uc003tud.1	-						CCT6P1_uc003tug.2_Intron|CCT6P1_uc003tuh.2_Intron|CCT6P1_uc003tui.2_Intron|uc003tuk.1_5'Flank					Homo sapiens hypothetical LOC441242, mRNA (cDNA clone MGC:87648 IMAGE:5267764), complete cds.																														---	---	---	---
LOC729156	729156	broad.mit.edu	37	7	66304731	66304733	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66304731_66304733delTTT	uc003tvj.1	-							NR_003934				Homo sapiens cDNA FLJ36054 fis, clone TESTI2018290.												0																		---	---	---	---
STAG3L4	64940	broad.mit.edu	37	7	66772872	66772873	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:66772872_66772873insT	uc003tvt.3	+						STAG3L4_uc010laj.2_Intron	NM_022906	NP_075057			stromal antigen 3-like 4												0		Lung NSC(55;0.0839)|all_lung(88;0.181)																---	---	---	---
TYW1B	441250	broad.mit.edu	37	7	72040751	72040751	+	Intron	DEL	A	-	-	rs72347331		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72040751delA	uc011kej.1	-						TYW1B_uc011keh.1_Intron|TYW1B_uc011kei.1_Intron	NM_001145440	NP_001138912			tRNA-yW synthesizing protein 1 homolog B isoform						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0																		---	---	---	---
TRIM50	135892	broad.mit.edu	37	7	72729267	72729267	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:72729267delA	uc010lbd.1	-						FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Intron|TRIM50_uc003txz.1_Intron	NM_178125	NP_835226			tripartite motif protein 50A							cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
ELN	2006	broad.mit.edu	37	7	73456758	73456759	+	Intron	DEL	AA	-	-	rs72489767		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:73456758_73456759delAA	uc003tzw.2	+						RFC2_uc011kfa.1_Intron|ELN_uc003tzm.1_Intron|ELN_uc011kfe.1_Intron|ELN_uc003tzn.2_Intron|ELN_uc003tzz.2_Intron|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Intron|ELN_uc003tzt.2_Intron|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Intron|ELN_uc011kff.1_Intron|ELN_uc003tzy.2_Intron	NM_000501	NP_001075224			elastin isoform a precursor						blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74105134	74105135	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74105134_74105135insT	uc003uau.2	+						GTF2I_uc003uat.2_Intron|GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74160629	74160629	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74160629delT	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_5'Flank	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
GTF2I	2969	broad.mit.edu	37	7	74163252	74163252	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74163252delA	uc003uau.2	+						GTF2I_uc003uav.2_Intron|GTF2I_uc003uaw.2_Intron|GTF2I_uc003uay.2_Intron|GTF2I_uc003uax.2_Intron|GTF2I_uc003uba.2_5'Flank	NM_032999	NP_127492			general transcription factor IIi isoform 1						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
WBSCR16	81554	broad.mit.edu	37	7	74470283	74470283	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:74470283delT	uc003ubr.2	-						WBSCR16_uc010lca.2_Intron|WBSCR16_uc010lcb.1_Intron	NM_030798	NP_110425			Williams-Beuren syndrome chromosome region 16												0																		---	---	---	---
POM121C	100101267	broad.mit.edu	37	7	75068666	75068666	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75068666delT	uc010lde.1	-						POM121C_uc003udk.3_Intron					Homo sapiens POM121-2 mRNA for nuclear pore membrane protein 121-2, partial cds.						mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0																		---	---	---	---
HIP1	3092	broad.mit.edu	37	7	75182913	75182914	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75182913_75182914delTT	uc003uds.1	-						HIP1_uc011kfz.1_Intron	NM_005338	NP_005329			huntingtin interacting protein 1						activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8								T	PDGFRB	CMML								---	---	---	---
SRRM3	222183	broad.mit.edu	37	7	75912537	75912537	+	Intron	DEL	G	-	-	rs3839766		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75912537delG	uc010ldi.2	+						SRRM3_uc003uet.1_Intron	NM_001110199	NP_001103669			serine/arginine repetitive matrix 3												0																		---	---	---	---
MAGI2	9863	broad.mit.edu	37	7	78256290	78256290	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:78256290delT	uc003ugx.2	-						MAGI2_uc003ugy.2_Intron|MAGI2_uc011kgr.1_Intron|MAGI2_uc011kgs.1_Intron	NM_012301	NP_036433			membrane associated guanylate kinase, WW and PDZ							cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)																---	---	---	---
CD36	948	broad.mit.edu	37	7	80141081	80141081	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:80141081delA	uc003uhc.2	+						GNAT3_uc011kgu.1_Intron	NM_001127444	NP_001120916			CD36 antigen						cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	82219160	82219160	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:82219160delT								CACNA2D1 (146129 upstream) : PCLO (164161 downstream)																																			---	---	---	---
KIAA1324L	222223	broad.mit.edu	37	7	86542523	86542523	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86542523delA	uc011kha.1	-						KIAA1324L_uc003uif.1_Intron|KIAA1324L_uc011kgz.1_Intron|KIAA1324L_uc003uie.2_Intron	NM_001142749	NP_001136221			hypothetical protein LOC222223 isoform 1							integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)																	---	---	---	---
KIAA1324L	222223	broad.mit.edu	37	7	86544016	86544016	+	Intron	DEL	A	-	-	rs76700134	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86544016delA	uc011kha.1	-						KIAA1324L_uc003uif.1_Intron|KIAA1324L_uc011kgz.1_Intron|KIAA1324L_uc003uie.2_Intron	NM_001142749	NP_001136221			hypothetical protein LOC222223 isoform 1							integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)																	---	---	---	---
DMTF1	9988	broad.mit.edu	37	7	86823978	86823978	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:86823978delT	uc003uih.2	+						DMTF1_uc003uii.2_Intron|DMTF1_uc003uij.2_Intron|DMTF1_uc011khb.1_Intron|DMTF1_uc003uik.2_Intron|DMTF1_uc003uil.2_Intron|DMTF1_uc003uin.2_Intron	NM_001142327	NP_001135799			cyclin D binding myb-like transcription factor 1						cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)																	---	---	---	---
ABCB4	5244	broad.mit.edu	37	7	87035854	87035854	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87035854delA	uc003uiv.1	-						ABCB4_uc003uiw.1_Intron|ABCB4_uc003uix.1_Intron	NM_018849	NP_061337			ATP-binding cassette, subfamily B, member 4						cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)																	---	---	---	---
SRI	6717	broad.mit.edu	37	7	87835976	87835976	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87835976delT	uc003ujq.1	-						SRI_uc011khg.1_Intron|SRI_uc003ujr.1_Intron	NM_003130	NP_003121			sorcin isoform a						heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			upper_aerodigestive_tract(1)	1	Esophageal squamous(14;0.00202)																	---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91609483	91609483	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91609483delT	uc003ulg.2	+						AKAP9_uc003uld.3_Intron|AKAP9_uc003ule.2_Intron|AKAP9_uc003ulf.2_Intron	NM_005751	NP_005742			A-kinase anchor protein 9 isoform 2						G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
KRIT1	889	broad.mit.edu	37	7	91856031	91856032	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91856031_91856032insA	uc003ulq.1	-						KRIT1_uc010lev.1_Intron|KRIT1_uc003ulr.1_Intron|KRIT1_uc003uls.1_Intron|KRIT1_uc003ult.1_Intron|KRIT1_uc003ulu.1_Intron|KRIT1_uc003ulv.1_Intron	NM_194456	NP_919438			krev interaction trapped 1 isoform 1						angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)											Familial_Cerebral_Cavernous_Angioma				---	---	---	---
ANKIB1	54467	broad.mit.edu	37	7	91980172	91980172	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91980172delA	uc003ulw.2	+							NM_019004	NP_061877			ankyrin repeat and IBR domain containing 1								protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)															---	---	---	---
ANKIB1	54467	broad.mit.edu	37	7	92000724	92000724	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92000724delT	uc003ulw.2	+						ANKIB1_uc010lew.1_5'Flank	NM_019004	NP_061877			ankyrin repeat and IBR domain containing 1								protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)															---	---	---	---
CCDC132	55610	broad.mit.edu	37	7	92883251	92883251	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:92883251delA	uc003umo.2	+						CCDC132_uc003umq.2_Intron|CCDC132_uc003ump.2_Intron|CCDC132_uc003umr.2_Intron|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Intron	NM_017667	NP_060137			coiled-coil domain containing 132 isoform a												0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)															---	---	---	---
Unknown	0	broad.mit.edu	37	7	93544428	93544428	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:93544428delA								GNGT1 (3943 upstream) : GNG11 (6588 downstream)																																			---	---	---	---
CASD1	64921	broad.mit.edu	37	7	94174999	94174999	+	Frame_Shift_Del	DEL	A	-	-	rs74907120		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94174999delA	uc003uni.3	+	12	1846	c.1619delA	c.(1618-1620)CAAfs	p.Q540fs	CASD1_uc003unj.3_Frame_Shift_Del_p.Q540fs	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	540						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
CASD1	64921	broad.mit.edu	37	7	94185017	94185017	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:94185017delT	uc003uni.3	+	18	2568	c.2341delT	c.(2341-2343)TTTfs	p.F781fs	CASD1_uc003unj.3_Frame_Shift_Del_p.F781fs	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	781	Helical; (Potential).					integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)															---	---	---	---
PON2	5445	broad.mit.edu	37	7	95045560	95045560	+	Frame_Shift_Del	DEL	A	-	-	rs115800748	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:95045560delA	uc003unv.2	-	3	316	c.195delT	c.(193-195)TTTfs	p.F65fs	PON2_uc003unu.2_Frame_Shift_Del_p.F65fs|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Intron	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	65					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)															---	---	---	---
TECPR1	25851	broad.mit.edu	37	7	97853041	97853043	+	Intron	DEL	GAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97853041_97853043delGAA	uc003upg.2	-							NM_015395	NP_056210			tectonin beta-propeller repeat containing 1							integral to membrane	protein binding			pancreas(1)	1																		---	---	---	---
TECPR1	25851	broad.mit.edu	37	7	97862098	97862101	+	Intron	DEL	AAAA	-	-	rs139511001		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97862098_97862101delAAAA	uc003upg.2	-						TECPR1_uc003uph.1_Intron	NM_015395	NP_056210			tectonin beta-propeller repeat containing 1							integral to membrane	protein binding			pancreas(1)	1																		---	---	---	---
BAIAP2L1	55971	broad.mit.edu	37	7	98015049	98015049	+	Intron	DEL	G	-	-	rs1635612	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98015049delG	uc003upj.2	-							NM_018842	NP_061330			BAI1-associated protein 2-like 1						filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98506643	98506651	+	Intron	DEL	TTTTTTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98506643_98506651delTTTTTTTTT	uc003upp.2	+						TRRAP_uc011kis.1_Intron|TRRAP_uc003upr.2_Intron	NM_003496	NP_003487			transformation/transcription domain-associated						histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
SMURF1	57154	broad.mit.edu	37	7	98654616	98654617	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98654616_98654617delAA	uc003upu.1	-						SMURF1_uc003upv.1_Intron|SMURF1_uc003upt.2_Intron	NM_020429	NP_065162			Smad ubiquitination regulatory factor 1 isoform						BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)															---	---	---	---
CYP3A4	1576	broad.mit.edu	37	7	99355990	99355990	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99355990delA	uc003urv.1	-						CYP3A4_uc003urw.1_Intron|CYP3A4_uc011kiz.1_Intron|CYP3A4_uc011kja.1_Intron|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488			cytochrome P450, family 3, subfamily A,						alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)													---	---	---	---
ZNF3	7551	broad.mit.edu	37	7	99672650	99672650	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99672650delA	uc003usq.2	-						ZNF3_uc003usp.2_Intron|ZNF3_uc003usr.2_Intron|ZNF3_uc010lgj.2_Intron|ZNF3_uc003uss.2_Intron|ZNF3_uc003ust.3_Intron	NM_032924	NP_116313			zinc finger protein 3 isoform 2						cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)															---	---	---	---
COPS6	10980	broad.mit.edu	37	7	99687409	99687409	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99687409delA	uc003usu.2	+						COPS6_uc011kjf.1_Frame_Shift_Del_p.*125fs	NM_006833	NP_006824			COP9 signalosome subunit 6						cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)															---	---	---	---
MCM7	4176	broad.mit.edu	37	7	99696597	99696598	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99696597_99696598insA	uc003usw.1	-						MCM7_uc003usv.1_Intron|MCM7_uc003usx.1_Intron|AP4M1_uc011kjg.1_5'Flank|AP4M1_uc010lgl.1_5'Flank|AP4M1_uc003utb.3_5'Flank|AP4M1_uc003utc.3_5'Flank|AP4M1_uc010lgm.2_5'Flank|AP4M1_uc003utd.2_5'Flank|AP4M1_uc011kjh.1_5'Flank|AP4M1_uc003ute.3_5'Flank	NM_005916	NP_005907			minichromosome maintenance complex component 7						cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)													---	---	---	---
AP4M1	9179	broad.mit.edu	37	7	99700685	99700689	+	Intron	DEL	TTTTT	-	-	rs67877430		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99700685_99700689delTTTTT	uc003utb.3	+						MCM7_uc003usv.1_5'Flank|MCM7_uc003usw.1_5'Flank|MCM7_uc003usx.1_5'Flank|AP4M1_uc011kjg.1_Intron|AP4M1_uc010lgl.1_Intron|AP4M1_uc003utc.3_Intron|AP4M1_uc010lgm.2_Intron|AP4M1_uc003utd.2_Intron|AP4M1_uc011kjh.1_Intron|AP4M1_uc003ute.3_Intron|AP4M1_uc003utf.3_Intron	NM_004722	NP_004713			adaptor-related protein complex 4, mu 1 subunit						intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
LRCH4	4034	broad.mit.edu	37	7	100174054	100174054	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100174054delT	uc003uvj.2	-						uc003uvh.2_5'Flank|LRCH4_uc010lgz.2_Intron|LRCH4_uc003uvi.2_Intron|LRCH4_uc011kjw.1_Intron	NM_002319	NP_002310			leucine-rich repeats and calponin homology (CH)						nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
EPHB4	2050	broad.mit.edu	37	7	100405271	100405272	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100405271_100405272delTT	uc003uwn.1	-						EPHB4_uc003uwm.1_Intron|EPHB4_uc010lhj.1_Intron	NM_004444	NP_004435			EPH receptor B4 precursor						cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
EPHB4	2050	broad.mit.edu	37	7	100416332	100416332	+	Intron	DEL	T	-	-	rs314364	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100416332delT	uc003uwn.1	-						EPHB4_uc003uwm.1_Intron|EPHB4_uc010lhj.1_Intron|EPHB4_uc011kkf.1_Intron|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Intron	NM_004444	NP_004435			EPH receptor B4 precursor						cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
EPHB4	2050	broad.mit.edu	37	7	100420298	100420298	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100420298delG	uc003uwn.1	-						EPHB4_uc003uwm.1_Intron|EPHB4_uc010lhj.1_Intron|EPHB4_uc011kkf.1_Intron|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Intron	NM_004444	NP_004435			EPH receptor B4 precursor						cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101837332	101837332	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101837332delT	uc003uyx.3	+						CUX1_uc003uys.3_Intron|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530			cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
CUX1	1523	broad.mit.edu	37	7	101839857	101839857	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101839857delT	uc003uyx.3	+						CUX1_uc003uys.3_Intron|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530			cut-like homeobox 1 isoform a						negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	102021199	102021199	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102021199delA	uc003uzd.1	+						uc003uze.1_Intron|PRKRIP1_uc003uzf.2_Intron|PRKRIP1_uc003uzg.2_Intron|PRKRIP1_uc011kkq.1_Intron	NM_001003686	NP_001003686			SubName: Full=Putative uncharacterized protein PMS2L3;																														---	---	---	---
FBXL13	222235	broad.mit.edu	37	7	102616291	102616291	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102616291delA	uc003vaq.2	-						FBXL13_uc010liq.1_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|FBXL13_uc003vav.2_Intron	NM_145032	NP_659469			F-box and leucine-rich repeat protein 13 isoform												0																		---	---	---	---
DPY19L2P2	349152	broad.mit.edu	37	7	102815706	102815708	+	3'UTR	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:102815706_102815708delTTT	uc003vbh.3	-	21					DPY19L2P2_uc003vbg.3_RNA|DPY19L2P2_uc010lit.2_RNA	NR_003561				RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103015097	103015097	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103015097delA	uc003vbz.2	-						SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_Intron|SLC26A5_uc003vbx.2_Intron|SLC26A5_uc003vby.2_Intron|SLC26A5_uc010liy.2_Intron	NM_198999	NP_945350			prestin isoform a						regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
SLC26A5	375611	broad.mit.edu	37	7	103029710	103029710	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103029710delT	uc003vbz.2	-						SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_Intron|SLC26A5_uc003vbx.2_Intron|SLC26A5_uc003vby.2_Intron|SLC26A5_uc010liy.2_Intron	NM_198999	NP_945350			prestin isoform a						regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
PUS7	54517	broad.mit.edu	37	7	105108923	105108923	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105108923delA	uc003vcx.2	-						PUS7_uc010lji.2_Intron|PUS7_uc003vcy.2_Intron|PUS7_uc003vcz.1_Intron	NM_019042	NP_061915			pseudouridylate synthase 7 homolog						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1																		---	---	---	---
RINT1	60561	broad.mit.edu	37	7	105182902	105182902	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105182902delA	uc003vda.1	+	4	552	c.321delA	c.(319-321)TTAfs	p.L107fs	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	107	Potential.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
RINT1	60561	broad.mit.edu	37	7	105187327	105187327	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105187327delA	uc003vda.1	+						RINT1_uc010ljj.1_Intron	NM_021930	NP_068749			RAD50 interactor 1						cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
COG5	10466	broad.mit.edu	37	7	106888797	106888797	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:106888797delT	uc003ved.2	-						COG5_uc003vec.2_Intron|COG5_uc003vee.2_Intron	NM_181733	NP_859422			component of oligomeric golgi complex 5 isoform						intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4																		---	---	---	---
PNPLA8	50640	broad.mit.edu	37	7	108150622	108150623	+	Intron	DEL	AA	-	-	rs35880371		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:108150622_108150623delAA	uc003vff.1	-						PNPLA8_uc003vfg.1_Intron|PNPLA8_uc003vfh.1_Intron|PNPLA8_uc003vfi.1_Intron|PNPLA8_uc003vfj.1_Intron|PNPLA8_uc003vfk.1_Intron	NM_015723	NP_056538			patatin-like phospholipase domain containing 8						fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2																		---	---	---	---
PNPLA8	50640	broad.mit.edu	37	7	108155904	108155907	+	Frame_Shift_Del	DEL	ATAT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:108155904_108155907delATAT	uc003vff.1	-	4	436_439	c.29_32delATAT	c.(28-33)TATATTfs	p.Y10fs	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Frame_Shift_Del_p.Y10fs|PNPLA8_uc003vfi.1_Intron|PNPLA8_uc003vfj.1_Frame_Shift_Del_p.Y10fs|PNPLA8_uc003vfk.1_Intron	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	10_11					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2																		---	---	---	---
DOCK4	9732	broad.mit.edu	37	7	111486893	111486893	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:111486893delA	uc003vfx.2	-						DOCK4_uc003vfw.2_Intron|DOCK4_uc003vfy.2_Intron	NM_014705	NP_055520			dedicator of cytokinesis 4						cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)																---	---	---	---
CFTR	1080	broad.mit.edu	37	7	117282669	117282670	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117282669_117282670insA	uc003vjd.2	+						CFTR_uc011knq.1_Intron	NM_000492	NP_000483			cystic fibrosis transmembrane conductance						respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)									Cystic_Fibrosis				---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117365403	117365403	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117365403delA	uc003vjf.2	-							NM_033427	NP_219499			cortactin binding protein 2											ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
CTTNBP2	83992	broad.mit.edu	37	7	117431318	117431318	+	Frame_Shift_Del	DEL	G	-	-	rs148428403		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117431318delG	uc003vjf.2	-	4	2024	c.1932delC	c.(1930-1932)CCCfs	p.P644fs		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	644										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)														---	---	---	---
C7orf58	79974	broad.mit.edu	37	7	120907107	120907107	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:120907107delA	uc003vjq.3	+							NM_024913	NP_079189			hypothetical protein LOC79974 isoform 1							endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)																	---	---	---	---
PTPRZ1	5803	broad.mit.edu	37	7	121597015	121597015	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121597015delA	uc003vjy.2	+						PTPRZ1_uc003vjz.2_Intron	NM_002851	NP_002842			protein tyrosine phosphatase, receptor-type,						central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9																		---	---	---	---
AASS	10157	broad.mit.edu	37	7	121753834	121753834	+	Intron	DEL	A	-	-	rs36059311		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:121753834delA	uc003vka.2	-						AASS_uc011knu.1_Intron|AASS_uc011knv.1_Intron|AASS_uc003vkb.2_Intron|AASS_uc011knw.1_Intron	NM_005763	NP_005754			aminoadipate-semialdehyde synthase precursor						protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
CADPS2	93664	broad.mit.edu	37	7	122054200	122054200	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:122054200delA	uc010lkp.2	-						CADPS2_uc011knx.1_Intron|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424			Ca2+-dependent activator protein for secretion 2						exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ASB15	142685	broad.mit.edu	37	7	123254294	123254294	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:123254294delA	uc003vku.1	+						ASB15_uc003vkv.1_Intron|ASB15_uc003vkw.1_Intron	NM_080928	NP_563616			ankyrin repeat and SOCS box-containing 15						intracellular signal transduction					skin(2)|lung(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	128706063	128706063	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128706063delT								TPI1P2 (8770 upstream) : LOC407835 (60262 downstream)																																			---	---	---	---
TMEM209	84928	broad.mit.edu	37	7	129815503	129815503	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:129815503delA	uc003vpn.2	-						TMEM209_uc010lmc.1_Intron	NM_032842	NP_116231			transmembrane protein 209							integral to membrane				ovary(2)|large_intestine(1)	3	Melanoma(18;0.0435)																	---	---	---	---
MEST	4232	broad.mit.edu	37	7	130139661	130139663	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130139661_130139663delAAA	uc003vqg.2	+						MEST_uc003vqc.2_Intron|MEST_uc003vqd.2_Intron|MEST_uc003vqf.2_Intron|MEST_uc011kph.1_Intron|MEST_uc010lmg.2_Intron	NM_002402	NP_002393			mesoderm specific transcript isoform a						mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			ovary(2)	2	Melanoma(18;0.0435)																	---	---	---	---
CHCHD3	54927	broad.mit.edu	37	7	132719215	132719216	+	Intron	INS	-	A	A	rs10488217	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:132719215_132719216insA	uc003vre.2	-						CHCHD3_uc010lmi.2_Intron|CHCHD3_uc003vrf.2_Intron|CHCHD3_uc010lmj.2_Intron|CHCHD3_uc011kpn.1_Intron	NM_017812	NP_060282			coiled-coil-helix-coiled-coil-helix domain						inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	7	132855363	132855363	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:132855363delT								CHCHD3 (88535 upstream) : EXOC4 (82460 downstream)																																			---	---	---	---
AKR1B15	441282	broad.mit.edu	37	7	134252866	134252866	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134252866delA	uc011kpr.1	+						AKR1B15_uc003vrt.2_Intron|AKR1B15_uc011kps.1_Intron	NM_001080538	NP_001074007			aldo-keto reductase family 1, member B15								oxidoreductase activity			ovary(1)	1																		---	---	---	---
CALD1	800	broad.mit.edu	37	7	134576462	134576462	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134576462delT	uc003vrz.2	+						CALD1_uc003vry.2_Intron|CALD1_uc003vsa.2_Intron|CALD1_uc003vsb.2_Intron|CALD1_uc010lmm.2_Intron|CALD1_uc011kpt.1_Intron|CALD1_uc003vsc.2_Intron|CALD1_uc003vsd.2_Intron	NM_033138	NP_149129			caldesmon 1 isoform 1						cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0																		---	---	---	---
STRA8	346673	broad.mit.edu	37	7	134930220	134930221	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:134930220_134930221insA	uc011kpx.1	+							NM_182489	NP_872295			STRA8						DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0																		---	---	---	---
LUZP6	767558	broad.mit.edu	37	7	135636279	135636280	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135636279_135636280insT	uc003vte.3	-	2	527_528	c.171_172insA	c.(169-174)AAAGGAfs	p.K57fs	LUZP6_uc010lmv.2_Intron	NM_145808	NP_665807	Q538Z0	LUZP6_HUMAN	myotrophin	Error:Variant_position_missing_in_Q538Z0_after_alignment											0																		---	---	---	---
DGKI	9162	broad.mit.edu	37	7	137341101	137341101	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:137341101delT	uc003vtt.2	-						DGKI_uc003vtu.2_Intron	NM_004717	NP_004708			diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3																OREG0018350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TRIM24	8805	broad.mit.edu	37	7	138265557	138265557	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138265557delT	uc003vuc.2	+						TRIM24_uc003vub.2_Intron	NM_015905	NP_056989			transcriptional intermediary factor 1 alpha						cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8																		---	---	---	---
CLEC2L	154790	broad.mit.edu	37	7	139219232	139219232	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139219232delA	uc010lnd.2	+							NM_001080511	NP_001073980			C-type lectin domain family 2, member L							integral to membrane	sugar binding				0	Melanoma(164;0.233)																	---	---	---	---
JHDM1D	80853	broad.mit.edu	37	7	139820166	139820166	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:139820166delT	uc003vvm.2	-						JHDM1D_uc010lng.2_5'Flank	NM_030647	NP_085150			jumonji C domain containing histone demethylase						midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)																	---	---	---	---
DENND2A	27147	broad.mit.edu	37	7	140268732	140268732	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:140268732delT	uc010lnj.2	-						DENND2A_uc011kre.1_Intron|DENND2A_uc010lnk.2_Intron|DENND2A_uc003vvw.2_Intron|DENND2A_uc003vvx.2_Intron	NM_015689	NP_056504			DENN/MADD domain containing 2A											ovary(3)|breast(1)	4	Melanoma(164;0.00956)																	---	---	---	---
AGK	55750	broad.mit.edu	37	7	141352440	141352440	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141352440delT	uc003vwi.2	+							NM_018238	NP_060708			acylglycerol kinase precursor						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			ovary(1)|breast(1)	2	Melanoma(164;0.0171)																	---	---	---	---
WEE2	494551	broad.mit.edu	37	7	141429163	141429163	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141429163delT	uc003vwn.2	+						FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028			WEE1 homolog 2						egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)																	---	---	---	---
MGAM	8972	broad.mit.edu	37	7	141736720	141736720	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141736720delC	uc003vwy.2	+	18	2228	c.2174delC	c.(2173-2175)ACCfs	p.T725fs		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	725	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)													---	---	---	---
TRPV5	56302	broad.mit.edu	37	7	142630710	142630711	+	5'UTR	DEL	GT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142630710_142630711delGT	uc003wby.1	-	1					TRPV5_uc003wbz.2_5'UTR	NM_019841	NP_062815			transient receptor potential cation channel,						protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	148751396	148751396	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148751396delA								PDIA4 (25614 upstream) : ZNF786 (15337 downstream)																																			---	---	---	---
SSPO	23145	broad.mit.edu	37	7	149494347	149494347	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149494347delT	uc010lpk.2	+							NM_198455	NP_940857			SCO-spondin precursor						cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)															---	---	---	---
KCNH2	3757	broad.mit.edu	37	7	150650045	150650045	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150650045delA	uc003wic.2	-						KCNH2_uc003wib.2_Intron|KCNH2_uc011kux.1_Intron|KCNH2_uc003wid.2_Intron|KCNH2_uc003wie.2_Intron	NM_000238	NP_000229			voltage-gated potassium channel, subfamily H,						blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)													---	---	---	---
ATG9B	285973	broad.mit.edu	37	7	150719079	150719080	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150719079_150719080delTT	uc011kvc.1	-						ATG9B_uc003wig.3_Intron	NM_173681	NP_775952			ATG9 autophagy related 9 homolog B						autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
CRYGN	155051	broad.mit.edu	37	7	151134909	151134909	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151134909delC	uc003wke.2	-						CRYGN_uc003wkf.2_Intron|CRYGN_uc003wkg.2_Intron|CRYGN_uc010lqd.1_5'Flank	NM_144727	NP_653328			gammaN-crystallin												0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151902157	151902157	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151902157delA	uc003wla.2	-						MLL3_uc003wkz.2_Intron	NM_170606	NP_733751			myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
ACTR3B	57180	broad.mit.edu	37	7	152549035	152549035	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:152549035delA	uc003wle.1	+						ACTR3B_uc003wlf.1_Intron|ACTR3B_uc003wlg.1_Intron|ACTR3B_uc011kvp.1_Intron	NM_020445	NP_065178			actin-related protein 3-beta isoform 1						regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding				0		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)														---	---	---	---
DPP6	1804	broad.mit.edu	37	7	154645548	154645548	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154645548delT	uc003wlk.2	+						DPP6_uc003wli.2_Intron|DPP6_uc003wlm.2_Intron|DPP6_uc011kvq.1_Intron	NM_130797	NP_570629			dipeptidyl-peptidase 6 isoform 1						cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)															---	---	---	---
PAXIP1	22976	broad.mit.edu	37	7	154782740	154782740	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:154782740delA	uc003wlp.2	-	4	343	c.300delT	c.(298-300)TTTfs	p.F100fs	PAXIP1_uc003wlq.1_Frame_Shift_Del_p.L12fs|PAXIP1_uc011kvs.1_Intron	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	100	BRCT 2.|Interaction with PA1 (By similarity).				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)														---	---	---	---
RBM33	155435	broad.mit.edu	37	7	155473256	155473256	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:155473256delT	uc010lqk.1	+						RBM33_uc003wme.2_Intron	NM_053043	NP_444271			RNA binding motif protein 33								nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)														---	---	---	---
Unknown	0	broad.mit.edu	37	7	159024963	159024963	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:159024963delT								VIPR2 (87314 upstream) : None (None downstream)																																			---	---	---	---
CSMD1	64478	broad.mit.edu	37	8	2799865	2799866	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:2799865_2799866delAA	uc011kwk.1	-						CSMD1_uc011kwj.1_Intron|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094			CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)														---	---	---	---
SLC7A2	6542	broad.mit.edu	37	8	17412323	17412323	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17412323delT	uc011kyc.1	+						SLC7A2_uc011kyd.1_Intron|SLC7A2_uc011kye.1_Intron|SLC7A2_uc011kyf.1_Intron	NM_001008539	NP_001008539			solute carrier family 7, member 2 isoform 2						cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)													---	---	---	---
FGL1	2267	broad.mit.edu	37	8	17722274	17722275	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:17722274_17722275insA	uc003wxx.2	-						FGL1_uc003wxy.2_Intron|FGL1_uc003wxz.2_Intron|FGL1_uc003wya.2_Intron|FGL1_uc003wyb.2_Intron|FGL1_uc003wyc.2_Intron|FGL1_uc003wyd.2_Intron|FGL1_uc003wye.2_Intron|FGL1_uc003wyf.2_Intron	NM_201553	NP_963847			fibrinogen-like 1 precursor						signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)														---	---	---	---
PPP3CC	5533	broad.mit.edu	37	8	22368795	22368796	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22368795_22368796insT	uc003xbs.2	+						PPP3CC_uc003xbr.1_Intron|PPP3CC_uc011kzi.1_Intron|PPP3CC_uc003xbt.2_Intron	NM_005605	NP_005596			protein phosphatase 3, catalytic subunit, gamma						activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)														---	---	---	---
EBF2	64641	broad.mit.edu	37	8	25890746	25890746	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25890746delT	uc003xes.1	-						PPP2R2A_uc003xek.2_Intron|EBF2_uc003xet.1_Intron	NM_022659	NP_073150			early B-cell factor 2						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)														---	---	---	---
C8orf80	389643	broad.mit.edu	37	8	27880849	27880849	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27880849delG	uc003xgm.3	-	19	2519	c.2376delC	c.(2374-2376)CCCfs	p.P792fs		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	792						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)														---	---	---	---
C8orf80	389643	broad.mit.edu	37	8	27888776	27888776	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27888776delT	uc003xgm.3	-	15	2035	c.1892delA	c.(1891-1893)AATfs	p.N631fs		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	631						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)														---	---	---	---
C8orf80	389643	broad.mit.edu	37	8	27927265	27927265	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27927265delA	uc003xgm.3	-							NM_001010906	NP_001010906			speckled-like pattern in the germinal center							nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)														---	---	---	---
KIF13B	23303	broad.mit.edu	37	8	28989772	28989772	+	Intron	DEL	A	-	-	rs112826611		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:28989772delA	uc003xhh.3	-						uc003xhi.1_Intron	NM_015254	NP_056069			kinesin family member 13B						microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)														---	---	---	---
RBPMS	11030	broad.mit.edu	37	8	30336817	30336817	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30336817delT	uc003xic.1	+						RBPMS_uc003xid.1_Intron|RBPMS_uc003xie.1_Intron|RBPMS_uc003xif.1_Intron|RBPMS_uc011lba.1_Intron|RBPMS_uc003xib.2_Intron|RBPMS_uc010lvh.1_Intron	NM_006867	NP_006858			RNA-binding protein with multiple splicing						positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|nucleus	nucleotide binding|poly(A) RNA binding|protein binding|transcription coactivator activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.144)|Kidney(114;0.172)														---	---	---	---
GTF2E2	2961	broad.mit.edu	37	8	30472065	30472065	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30472065delA	uc003xig.2	-							NM_002095	NP_002086			general transcription factor IIE, polypeptide 2,						regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)														---	---	---	---
WRN	7486	broad.mit.edu	37	8	30968994	30968995	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30968994_30968995insA	uc003xio.3	+						WRN_uc010lvk.2_Intron	NM_000553	NP_000544			Werner syndrome protein						base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)				Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---	---
NRG1	3084	broad.mit.edu	37	8	32620721	32620721	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:32620721delT	uc003xiv.2	+						NRG1_uc010lvo.2_Intron|NRG1_uc003xiu.2_Intron|NRG1_uc003xiw.2_Intron|NRG1_uc003xit.2_Intron|NRG1_uc010lvr.2_Intron|NRG1_uc010lvs.2_Intron|NRG1_uc010lvp.2_Intron|NRG1_uc010lvq.2_Intron|NRG1_uc011lbg.1_Intron|NRG1_uc011lbh.1_Intron|NRG1_uc003xja.2_Intron	NM_013964	NP_039258			neuregulin 1 isoform HRG-alpha						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)														---	---	---	---
C8orf41	80185	broad.mit.edu	37	8	33367498	33367504	+	Intron	DEL	AAAAAAA	-	-	rs36055824		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:33367498_33367504delAAAAAAA	uc003xjl.3	-						C8orf41_uc003xjk.3_Intron|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Intron|C8orf41_uc003xjn.1_Intron	NM_025115	NP_079391			hypothetical protein LOC80185								binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)														---	---	---	---
RAB11FIP1	80223	broad.mit.edu	37	8	37720397	37720397	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37720397delT	uc003xkm.1	-	6					RAB11FIP1_uc010lvz.1_3'UTR|RAB11FIP1_uc003xkn.1_3'UTR|RAB11FIP1_uc003xkl.1_3'UTR	NM_001002814	NP_001002814			RAB11 family interacting protein 1 isoform 3						protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)															---	---	---	---
WHSC1L1	54904	broad.mit.edu	37	8	38195051	38195051	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38195051delA	uc003xli.2	-						WHSC1L1_uc011lbm.1_Intron|WHSC1L1_uc010lwe.2_Intron|WHSC1L1_uc003xlj.2_Intron	NM_023034	NP_075447			WHSC1L1 protein isoform long						cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)					T	NUP98	AML								---	---	---	---
ADAM2	2515	broad.mit.edu	37	8	39602328	39602328	+	Intron	DEL	A	-	-	rs143373254	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39602328delA	uc003xnj.2	-						ADAM2_uc003xnk.2_Intron|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455			ADAM metallopeptidase domain 2 proprotein						cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)														---	---	---	---
ADAM2	2515	broad.mit.edu	37	8	39634686	39634686	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39634686delA	uc003xnj.2	-						ADAM2_uc003xnk.2_Intron|ADAM2_uc011lck.1_Intron|ADAM2_uc003xnl.2_Intron	NM_001464	NP_001455			ADAM metallopeptidase domain 2 proprotein						cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)														---	---	---	---
IDO2	169355	broad.mit.edu	37	8	39871287	39871287	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:39871287delT	uc010lwy.1	+						IDO2_uc003xno.1_Intron|IDO2_uc010lwz.1_Intron|IDO2_uc003xnp.1_Intron	NM_194294	NP_919270			indoleamine-pyrrole 2,3 dioxygenase-like 1						tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2																		---	---	---	---
POLB	5423	broad.mit.edu	37	8	42227357	42227358	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42227357_42227358delTT	uc003xoz.1	+						POLB_uc003xpa.1_Intron|POLB_uc011lcs.1_Intron	NM_002690	NP_002681			DNA-directed DNA polymerase beta						DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)								DNA_polymerases_(catalytic_subunits)					---	---	---	---
SGK196	84197	broad.mit.edu	37	8	42978201	42978202	+	3'UTR	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42978201_42978202delTT	uc003xpw.2	+	5						NM_032237	NP_115613			protein kinase-like protein SgK196							integral to membrane	ATP binding|protein kinase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	8	43794168	43794168	+	IGR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:43794168delG								POTEA (575840 upstream) : None (None downstream)																																			---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48849187	48849187	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48849187delT	uc003xqi.2	-						PRKDC_uc003xqj.2_Intron|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835			protein kinase, DNA-activated, catalytic						cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
Unknown	0	broad.mit.edu	37	8	49297743	49297743	+	IGR	DEL	A	-	-	rs140564135		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:49297743delA								UBE2V2 (323291 upstream) : EFCAB1 (325608 downstream)																																			---	---	---	---
SNTG1	54212	broad.mit.edu	37	8	51362183	51362183	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:51362183delT	uc010lxy.1	+						SNTG1_uc003xqs.1_Intron|SNTG1_uc010lxz.1_Intron|SNTG1_uc011ldl.1_Intron	NM_018967	NP_061840			syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)																---	---	---	---
SNTG1	54212	broad.mit.edu	37	8	51664475	51664475	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:51664475delT	uc010lxy.1	+						SNTG1_uc003xqs.1_Intron|SNTG1_uc010lxz.1_Intron|SNTG1_uc011ldl.1_Intron	NM_018967	NP_061840			syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)																---	---	---	---
PXDNL	137902	broad.mit.edu	37	8	52252040	52252040	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:52252040delA	uc003xqu.3	-						PXDNL_uc003xqt.3_Intron	NM_144651	NP_653252			peroxidasin homolog-like precursor						hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)																---	---	---	---
IMPAD1	54928	broad.mit.edu	37	8	57879056	57879056	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:57879056delT	uc003xte.3	-							NM_017813	NP_060283			inositol monophosphatase domain containing 1							Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)																---	---	---	---
CA8	767	broad.mit.edu	37	8	61139553	61139553	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61139553delA	uc003xtz.1	-						CA8_uc003xua.1_Intron	NM_004056	NP_004047			carbonic anhydrase VIII						one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)																---	---	---	---
CHD7	55636	broad.mit.edu	37	8	61714076	61714076	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:61714076delT	uc003xue.2	+							NM_017780	NP_060250			chromodomain helicase DNA binding protein 7						central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)															---	---	---	---
ASPH	444	broad.mit.edu	37	8	62480019	62480019	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62480019delA	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
ASPH	444	broad.mit.edu	37	8	62538943	62538944	+	Intron	DEL	TT	-	-	rs78469859	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62538943_62538944delTT	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
ASPH	444	broad.mit.edu	37	8	62557196	62557196	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:62557196delA	uc003xuj.2	-						ASPH_uc011leg.1_Intron|ASPH_uc003xuo.2_Intron|ASPH_uc011leh.1_Intron|ASPH_uc003xul.2_Intron|ASPH_uc011lei.1_Intron|ASPH_uc011lej.1_Intron|ASPH_uc003xun.2_Intron|ASPH_uc011lek.1_Intron|ASPH_uc003xum.2_Intron	NM_004318	NP_004309			aspartate beta-hydroxylase isoform a						muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)													---	---	---	---
PDE7A	5150	broad.mit.edu	37	8	66695083	66695083	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:66695083delA	uc003xvq.2	-						PDE7A_uc003xvr.2_Intron|PDE7A_uc003xvp.2_Intron	NM_002604	NP_002595			phosphodiesterase 7A isoform b							cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)													---	---	---	---
TRIM55	84675	broad.mit.edu	37	8	67047953	67047953	+	Intron	DEL	A	-	-	rs113103806	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67047953delA	uc003xvv.2	+						TRIM55_uc003xvu.2_Intron|TRIM55_uc003xvw.2_Intron|TRIM55_uc003xvx.2_Intron	NM_184085	NP_908973			tripartite motif-containing 55 isoform 1							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)															---	---	---	---
ADHFE1	137872	broad.mit.edu	37	8	67357336	67357336	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67357336delA	uc003xwb.3	+						ADHFE1_uc003xwd.3_Intron|ADHFE1_uc003xwc.3_Intron|ADHFE1_uc003xwe.3_Intron|ADHFE1_uc003xwf.3_Intron|ADHFE1_uc011les.1_Intron|ADHFE1_uc011leq.1_Intron|ADHFE1_uc011ler.1_Intron	NM_144650	NP_653251			alcohol dehydrogenase, iron containing, 1						2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)															---	---	---	---
MYBL1	4603	broad.mit.edu	37	8	67488741	67488741	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67488741delT	uc003xwj.2	-						MYBL1_uc003xwl.2_Intron|MYBL1_uc003xwk.2_Intron	NM_001080416	NP_001073885			v-myb myeloblastosis viral oncogene homolog						positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)															---	---	---	---
COPS5	10987	broad.mit.edu	37	8	67955557	67955557	+	Intron	DEL	A	-	-	rs71645628		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:67955557delA	uc003xxe.2	-						COPS5_uc003xxd.2_Intron|COPS5_uc003xxf.2_Intron	NM_006837	NP_006828			COP9 signalosome subunit 5						cullin deneddylation|transcription from RNA polymerase II promoter	eukaryotic translation initiation factor 3 complex|signalosome	metal ion binding|metallopeptidase activity|protein binding|transcription coactivator activity|translation initiation factor activity			ovary(1)|skin(1)	2	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00389)|OV - Ovarian serous cystadenocarcinoma(28;0.00691)|all cancers(69;0.0205)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
C8orf34	116328	broad.mit.edu	37	8	69380911	69380911	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:69380911delT	uc010lyz.2	+						C8orf34_uc010lyy.1_Intron|C8orf34_uc003xyb.2_Intron	NM_052958	NP_443190			hypothetical protein LOC116328						signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)															---	---	---	---
ZNF704	619279	broad.mit.edu	37	8	81723896	81723896	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:81723896delA	uc003yby.1	-							NM_001033723	NP_001028895			zinc finger protein 704							intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)															---	---	---	---
Unknown	0	broad.mit.edu	37	8	82530375	82530375	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:82530375delT								FABP12 (86825 upstream) : IMPA1 (38776 downstream)																																			---	---	---	---
CNGB3	54714	broad.mit.edu	37	8	87683336	87683336	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:87683336delA	uc003ydx.2	-						CNGB3_uc010maj.2_5'Flank	NM_019098	NP_061971			cyclic nucleotide gated channel beta 3						signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	8	90351204	90351204	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90351204delA								None (None upstream) : RIPK2 (418771 downstream)																																			---	---	---	---
RIPK2	8767	broad.mit.edu	37	8	90784771	90784771	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90784771delG	uc003yee.2	+						RIPK2_uc003yef.2_Intron	NM_003821	NP_003812			receptor-interacting serine-threonine kinase 2						activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)															---	---	---	---
OSGIN2	734	broad.mit.edu	37	8	90921779	90921779	+	Intron	DEL	T	-	-	rs73696834	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90921779delT	uc003yeg.2	+						OSGIN2_uc003yeh.2_Intron	NM_004337	NP_004328			oxidative stress induced growth inhibitor family						germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)															---	---	---	---
NBN	4683	broad.mit.edu	37	8	90948043	90948043	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90948043delA	uc003yej.1	-						NBN_uc003yei.1_Intron|NBN_uc011lgb.1_Intron	NM_002485	NP_002476			nibrin						cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)										Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				---	---	---	---
NBN	4683	broad.mit.edu	37	8	90983635	90983635	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:90983635delT	uc003yej.1	-						NBN_uc003yei.1_Intron|NBN_uc011lgb.1_Intron	NM_002485	NP_002476			nibrin						cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)										Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				---	---	---	---
DECR1	1666	broad.mit.edu	37	8	91056917	91056918	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91056917_91056918delTT	uc003yek.1	+						DECR1_uc011lgc.1_Intron|DECR1_uc011lgd.1_Intron	NM_001359	NP_001350			2,4-dienoyl CoA reductase 1 precursor						fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH				0			BRCA - Breast invasive adenocarcinoma(11;0.00953)															---	---	---	---
CALB1	793	broad.mit.edu	37	8	91094055	91094055	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:91094055delT	uc003yel.1	-						CALB1_uc003yem.1_Intron|CALB1_uc011lge.1_5'Flank	NM_004929	NP_004920			calbindin 1							nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)															---	---	---	---
RBM12B	389677	broad.mit.edu	37	8	94745548	94745548	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:94745548delA	uc003yfz.2	-	3						NM_203390	NP_976324			RNA binding motif protein 12B								nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)															---	---	---	---
RAD54B	25788	broad.mit.edu	37	8	95420018	95420018	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95420018delA	uc003ygk.2	-						RAD54B_uc010may.1_Intron|RAD54B_uc003ygl.1_Intron	NM_012415	NP_036547			RAD54 homolog B						double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
CCNE2	9134	broad.mit.edu	37	8	95903888	95903896	+	Intron	DEL	AAAAAAAAA	-	-	rs78334619		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95903888_95903896delAAAAAAAAA	uc003yhc.2	-						CCNE2_uc003yhd.2_Intron	NM_057749	NP_477097			cyclin E2						cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding				0	Breast(36;8.75e-07)																	---	---	---	---
RPL30	6156	broad.mit.edu	37	8	99054504	99054504	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99054504delT	uc003yif.2	-						RPL30_uc010mbk.1_Intron|SNORA72_uc003yig.1_5'Flank	NM_000989	NP_000980			ribosomal protein L30						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.192)															---	---	---	---
POP1	10940	broad.mit.edu	37	8	99148630	99148630	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99148630delA	uc003yij.3	+						POP1_uc011lgv.1_Intron|POP1_uc003yik.2_Intron	NM_001145860	NP_001139332			processing of precursor 1						tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
VPS13B	157680	broad.mit.edu	37	8	100513893	100513893	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:100513893delT	uc003yiv.2	+						VPS13B_uc003yiw.2_Intron|VPS13B_uc003yiu.1_Intron|VPS13B_uc003yix.1_Intron	NM_017890	NP_060360			vacuolar protein sorting 13B isoform 5						protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)															---	---	---	---
YWHAZ	7534	broad.mit.edu	37	8	101936665	101936666	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:101936665_101936666delTT	uc011lhe.1	-						YWHAZ_uc003yjv.2_Intron|YWHAZ_uc011lhf.1_Intron|YWHAZ_uc003yjw.2_Intron|YWHAZ_uc010mbq.2_Intron|YWHAZ_uc011lhg.1_Intron|YWHAZ_uc010mbr.2_Intron|YWHAZ_uc003yjx.2_Intron|YWHAZ_uc003yjy.2_Intron	NM_001135702	NP_001129174			tyrosine 3/tryptophan 5 -monooxygenase						anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)													---	---	---	---
Unknown	0	broad.mit.edu	37	8	102061482	102061482	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:102061482delC								YWHAZ (95859 upstream) : ZNF706 (147786 downstream)																																			---	---	---	---
NCALD	83988	broad.mit.edu	37	8	102859464	102859465	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:102859464_102859465delTT	uc003ykf.2	-						NCALD_uc003ykg.2_Intron|NCALD_uc003ykh.2_Intron|NCALD_uc003yki.2_Intron|NCALD_uc003ykj.2_Intron|NCALD_uc003ykk.2_Intron|NCALD_uc003ykl.2_Intron	NM_001040628	NP_001035718			neurocalcin delta						synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103271194	103271194	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103271194delT	uc003ykr.1	-						UBR5_uc003yks.1_Intron|UBR5_uc003ykq.2_Intron	NM_015902	NP_056986			ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
UBR5	51366	broad.mit.edu	37	8	103289349	103289349	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:103289349delT	uc003ykr.1	-	45	6393	c.6360delA	c.(6358-6360)AAAfs	p.K2120fs	UBR5_uc003yks.1_Frame_Shift_Del_p.K2120fs	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	2120					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)															---	---	---	---
BAALC	79870	broad.mit.edu	37	8	104225429	104225430	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104225429_104225430delAA	uc003yld.2	+						BAALC_uc003yle.2_Intron|uc003ylf.2_Intron|BAALC_uc003ylg.2_Intron|BAALC_uc010mcc.2_5'Flank	NM_024812	NP_079088			brain and acute leukemia, cytoplasmic isoform 1							centrosome|membrane|nucleus					0			OV - Ovarian serous cystadenocarcinoma(57;3.49e-05)|STAD - Stomach adenocarcinoma(118;0.133)															---	---	---	---
DCAF13	25879	broad.mit.edu	37	8	104439487	104439487	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104439487delT	uc003yln.2	+						DCAF13_uc003ylm.1_Intron|DCAF13_uc003ylo.2_Intron	NM_015420	NP_056235			WD repeats and SOF1 domain containing						rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1																		---	---	---	---
LRP12	29967	broad.mit.edu	37	8	105509439	105509440	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105509439_105509440insT	uc003yma.2	-	5	1435_1436	c.1340_1341insA	c.(1339-1341)AACfs	p.N447fs	LRP12_uc003ymb.2_Frame_Shift_Ins_p.N428fs|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	447	Extracellular (Potential).|LDL-receptor class A 4.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)															---	---	---	---
LRP12	29967	broad.mit.edu	37	8	105578277	105578277	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:105578277delA	uc003yma.2	-						LRP12_uc003ymb.2_Intron|LRP12_uc003ymc.3_Intron	NM_013437	NP_038465			low density lipoprotein-related protein 12						endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110464254	110464254	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110464254delT	uc003yne.2	+							NM_177531	NP_803875			fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113243713	113243713	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113243713delT	uc003ynu.2	-						CSMD3_uc003yns.2_Intron|CSMD3_uc003ynt.2_Intron|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756			CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
CSMD3	114788	broad.mit.edu	37	8	113662424	113662425	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:113662424_113662425insT	uc003ynu.2	-	19	3317_3318	c.3158_3159insA	c.(3157-3159)AACfs	p.N1053fs	CSMD3_uc003yns.2_Frame_Shift_Ins_p.N325fs|CSMD3_uc003ynt.2_Frame_Shift_Ins_p.N1013fs|CSMD3_uc011lhx.1_Frame_Shift_Ins_p.N949fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1053	Extracellular (Potential).|Sushi 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63															HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116426160	116426160	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116426160delT	uc003ynz.2	-	6					TRPS1_uc011lhy.1_3'UTR|TRPS1_uc003yny.2_3'UTR|TRPS1_uc010mcy.2_3'UTR	NM_014112	NP_054831			zinc finger transcription factor TRPS1						negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
EIF3H	8667	broad.mit.edu	37	8	117668365	117668366	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:117668365_117668366delAA	uc003yoa.2	-						EIF3H_uc003yob.2_Intron	NM_003756	NP_003747			eukaryotic translation initiation factor 3,						regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)																	---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120770136	120770136	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120770136delA	uc003you.2	-							NM_003184	NP_003175			TBP-associated factor 2						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
TAF2	6873	broad.mit.edu	37	8	120805739	120805739	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:120805739delT	uc003you.2	-							NM_003184	NP_003175			TBP-associated factor 2						G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)															---	---	---	---
COL14A1	7373	broad.mit.edu	37	8	121228754	121228754	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121228754delT	uc003yox.2	+						COL14A1_uc003yoy.2_Intron	NM_021110	NP_066933			collagen, type XIV, alpha 1 precursor						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
SNTB1	6641	broad.mit.edu	37	8	121648291	121648291	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:121648291delT	uc010mdg.2	-						SNTB1_uc003ype.2_Intron	NM_021021	NP_066301			basic beta 1 syntrophin						muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)															---	---	---	---
ANXA13	312	broad.mit.edu	37	8	124708147	124708147	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:124708147delC	uc003yqu.2	-						ANXA13_uc003yqt.2_Intron	NM_004306	NP_004297			annexin A13 isoform a						cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
TATDN1	83940	broad.mit.edu	37	8	125520941	125520942	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:125520941_125520942delAA	uc003yrd.2	-						TATDN1_uc003yre.2_Intron|TATDN1_uc010mdm.2_Intron|TATDN1_uc003yrf.2_Intron	NM_032026	NP_114415			TatD DNase domain containing 1 isoform a							nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)															---	---	---	---
KIAA0196	9897	broad.mit.edu	37	8	126059687	126059689	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:126059687_126059689delTTT	uc003yrt.2	-						KIAA0196_uc011lir.1_Intron|KIAA0196_uc003yru.1_Intron	NM_014846	NP_055661			strumpellin						cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)															---	---	---	---
PHF20L1	51105	broad.mit.edu	37	8	133816754	133816754	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133816754delA	uc003ytt.2	+						PHF20L1_uc003ytr.2_Intron|PHF20L1_uc010mdv.2_Intron|PHF20L1_uc003yts.2_Intron|PHF20L1_uc011lja.1_Intron|PHF20L1_uc003ytu.1_Intron|PHF20L1_uc003ytv.2_Intron	NM_016018	NP_057102			PHD finger protein 20-like 1 isoform 1								nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)															---	---	---	---
NDRG1	10397	broad.mit.edu	37	8	134262922	134262922	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134262922delA	uc003yuh.2	-						NDRG1_uc003yuf.1_Intron|NDRG1_uc003yug.2_Intron|NDRG1_uc010mee.2_Intron|NDRG1_uc010mef.2_Intron|NDRG1_uc011ljh.1_Intron|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714			N-myc downstream regulated 1						cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139792974	139792974	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139792974delG	uc003yvd.2	-							NM_152888	NP_690848			collagen, type XXII, alpha 1						cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
TRAPPC9	83696	broad.mit.edu	37	8	141034189	141034189	+	Intron	DEL	A	-	-	rs9792174	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141034189delA	uc003yvj.2	-						TRAPPC9_uc003yvh.2_Intron|TRAPPC9_uc010mel.1_Intron|TRAPPC9_uc003yvi.1_Intron	NM_001160372	NP_001153844			trafficking protein particle complex 9 isoform						cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2																		---	---	---	---
PTK2	5747	broad.mit.edu	37	8	141843275	141843275	+	Intron	DEL	A	-	-	rs141534503		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:141843275delA	uc003yvu.2	-						PTK2_uc003yvq.2_Intron|PTK2_uc003yvr.2_Intron|PTK2_uc003yvs.2_Intron|PTK2_uc003yvt.2_Intron|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Intron	NM_153831	NP_722560			PTK2 protein tyrosine kinase 2 isoform a						axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)															---	---	---	---
SLC45A4	57210	broad.mit.edu	37	8	142228274	142228274	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142228274delC	uc003ywd.1	-	4	1620	c.1312delG	c.(1312-1314)GAGfs	p.E438fs	SLC45A4_uc003ywc.1_Frame_Shift_Del_p.E438fs|SLC45A4_uc010meq.1_Frame_Shift_Del_p.E436fs	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	489					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
FLJ43860	389690	broad.mit.edu	37	8	142490161	142490161	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142490161delC	uc003ywi.2	-						FLJ43860_uc011ljs.1_Intron|FLJ43860_uc010meu.1_Intron	NM_207414	NP_997297			hypothetical protein LOC389690								binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
EPPK1	83481	broad.mit.edu	37	8	144940073	144940081	+	Splice_Site	DEL	AAAAAAAAC	-	-	rs6558397		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144940073_144940081delAAAAAAAAC	uc003zaa.1	-	3	15358	c.15345_splice	c.e3-1			NM_031308	NP_112598			epiplakin 1							cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
RECQL4	9401	broad.mit.edu	37	8	145738582	145738584	+	Intron	DEL	GGG	-	-	rs67678060		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145738582_145738584delGGG	uc003zdj.2	-							NM_004260	NP_004251			RecQ protein-like 4						DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)					N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				---	---	---	---
LRRC14	9684	broad.mit.edu	37	8	145748920	145748921	+	3'UTR	INS	-	G	G	rs142436931	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145748920_145748921insG	uc003zdk.1	+	4					LRRC24_uc003zdm.2_Intron|LRRC24_uc003zdn.2_Intron|LRRC14_uc003zdl.1_3'UTR|LRRC14_uc003zdo.2_Intron	NM_014665	NP_055480			leucine rich repeat containing 14												0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)															---	---	---	---
ARHGAP39	80728	broad.mit.edu	37	8	145763001	145763001	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145763001delC	uc003zdt.1	-						ARHGAP39_uc011llk.1_Intron|ARHGAP39_uc003zds.1_Intron	NM_025251	NP_079527			KIAA1688 protein						axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0																		---	---	---	---
RFX3	5991	broad.mit.edu	37	9	3266333	3266333	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:3266333delA	uc003zhr.2	-						RFX3_uc010mhd.2_Intron|RFX3_uc003zhs.1_Intron	NM_134428	NP_602304			regulatory factor X3 isoform b						cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)														---	---	---	---
CDC37L1	55664	broad.mit.edu	37	9	4702101	4702101	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4702101delT	uc003zio.2	+							NM_017913	NP_060383			cell division cycle 37 homolog (S.							cytoplasm					0	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)														---	---	---	---
RCL1	10171	broad.mit.edu	37	9	4833087	4833087	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:4833087delT	uc003zis.2	+						RCL1_uc003zit.2_Intron|RCL1_uc010mhk.1_Intron	NM_005772	NP_005763			RNA terminal phosphate cyclase-like 1						ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)														---	---	---	---
GLDC	2731	broad.mit.edu	37	9	6639660	6639661	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:6639660_6639661delAA	uc003zkc.2	-							NM_000170	NP_000161			glycine dehydrogenase (decarboxylating)						glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
KDM4C	23081	broad.mit.edu	37	9	7128278	7128279	+	Intron	DEL	AA	-	-	rs73403349	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:7128278_7128279delAA	uc003zkh.2	+						KDM4C_uc011lmj.1_Intron|KDM4C_uc003zkg.2_Intron|KDM4C_uc011lmk.1_Intron|KDM4C_uc011lml.1_Intron	NM_015061	NP_055876			jumonji domain containing 2C isoform 1						positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1																		---	---	---	---
PTPRD	5789	broad.mit.edu	37	9	8507244	8507244	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:8507244delA	uc003zkk.2	-						PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Intron|PTPRD_uc003zkm.2_Intron|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830			protein tyrosine phosphatase, receptor type, D						transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)											TSP Lung(15;0.13)			---	---	---	---
TYRP1	7306	broad.mit.edu	37	9	12708067	12708068	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:12708067_12708068insC	uc003zkv.3	+	7	1510_1511	c.1332_1333insC	c.(1330-1335)TGGCCCfs	p.W444fs		NM_000550	NP_000541	P17643	TYRP1_HUMAN	tyrosinase-related protein 1 precursor	444_445	Lumenal, melanosome (Potential).				melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			lung(1)	1		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)										Oculocutaneous_Albinism				---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13125277	13125277	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13125277delT	uc010mia.1	-	34	4802	c.4745delA	c.(4744-4746)AAGfs	p.K1582fs	MPDZ_uc003zky.3_Frame_Shift_Del_p.K144fs|MPDZ_uc010mib.2_Frame_Shift_Del_p.K287fs|MPDZ_uc010mhx.2_Frame_Shift_Del_p.K404fs|MPDZ_uc011lmm.1_Frame_Shift_Del_p.K441fs|MPDZ_uc003zkz.3_Frame_Shift_Del_p.K275fs|MPDZ_uc010mhy.2_Frame_Shift_Del_p.K1582fs|MPDZ_uc010mhz.2_Frame_Shift_Del_p.K1549fs|MPDZ_uc011lmn.1_Frame_Shift_Del_p.K1549fs|MPDZ_uc003zlb.3_Frame_Shift_Del_p.K1582fs	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1582					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13221302	13221302	+	Intron	DEL	A	-	-	rs141630257	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13221302delA	uc010mia.1	-						MPDZ_uc010mhy.2_Intron|MPDZ_uc010mhz.2_Intron|MPDZ_uc011lmn.1_Intron|MPDZ_uc003zlb.3_Intron	NM_003829	NP_003820			multiple PDZ domain protein						interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14759696	14759696	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14759696delA	uc003zlm.2	-						FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Intron	NM_144966	NP_659403			FRAS1 related extracellular matrix 1 precursor						cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14859501	14859501	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14859501delA	uc003zlm.2	-						FREM1_uc010mic.2_Intron	NM_144966	NP_659403			FRAS1 related extracellular matrix 1 precursor						cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	15034726	15034726	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:15034726delA	uc003zln.1	-											Homo sapiens cDNA FLJ46077 fis, clone TESTI2003768, weakly  similar to Chloride channel protein 3.																														---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19372238	19372238	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19372238delT	uc003znq.2	+	28					DENND4C_uc011lnc.1_3'UTR|DENND4C_uc011lnd.1_3'UTR|DENND4C_uc003znr.2_3'UTR|DENND4C_uc003zns.2_3'UTR	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
IFT74	80173	broad.mit.edu	37	9	26980558	26980558	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:26980558delT	uc010mja.2	+						IFT74_uc010mjb.2_Intron|IFT74_uc003zqf.3_Intron|IFT74_uc003zqg.3_Intron	NM_001099223	NP_001092693			coiled-coil domain containing 2 isoform a							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				skin(1)	1		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)														---	---	---	---
TAF1L	138474	broad.mit.edu	37	9	32633025	32633025	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:32633025delT	uc003zrg.1	-	1	2643	c.2553delA	c.(2551-2553)AAAfs	p.K851fs	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	851					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)														---	---	---	---
CHMP5	51510	broad.mit.edu	37	9	33270523	33270523	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33270523delT	uc003zsl.3	+						SUGT1P1_uc010mjq.1_Intron|CHMP5_uc003zsm.3_Intron|CHMP5_uc011lnv.1_Intron|CHMP5_uc003zsn.2_5'Flank	NM_016410	NP_057494			chromatin modifying protein 5						cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)															---	---	---	---
AQP7	364	broad.mit.edu	37	9	33386780	33386781	+	Intron	INS	-	A	A	rs144468472	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:33386780_33386781insA	uc003zst.2	-						SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Intron|AQP7_uc010mjs.2_Intron|AQP7_uc010mjt.2_Intron|AQP7_uc011lnx.1_Intron|AQP7_uc011lny.1_Intron|AQP7_uc003zss.3_Intron|AQP7_uc011lnz.1_Intron|AQP7_uc011loa.1_Intron	NM_001170	NP_001161			aquaporin 7						excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)														---	---	---	---
C9orf24	84688	broad.mit.edu	37	9	34385894	34385894	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:34385894delC	uc003zuh.1	-							NM_032596	NP_115985			testes development-related NYD-SP22 isoform 1											ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.123)														---	---	---	---
RNF38	152006	broad.mit.edu	37	9	36353341	36353343	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36353341_36353343delAAA	uc003zzh.2	-						RNF38_uc003zzi.2_Intron|RNF38_uc003zzj.2_Intron|RNF38_uc003zzk.2_Intron|RNF38_uc003zzl.2_Intron|RNF38_uc003zzm.2_Intron	NM_022781	NP_073618			ring finger protein 38 isoform 1								zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
MELK	9833	broad.mit.edu	37	9	36671220	36671220	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:36671220delT	uc003zzn.2	+						MELK_uc011lpm.1_Intron|MELK_uc011lpn.1_Intron|MELK_uc011lpo.1_Intron|MELK_uc010mll.2_Intron|MELK_uc011lpp.1_Intron|MELK_uc010mlm.2_Intron|MELK_uc011lpq.1_Intron|MELK_uc011lpr.1_Intron|MELK_uc011lps.1_Intron	NM_014791	NP_055606			maternal embryonic leucine zipper kinase							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)															---	---	---	---
POLR1E	64425	broad.mit.edu	37	9	37489233	37489234	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37489233_37489234delAA	uc003zzz.1	+						POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935			RNA polymerase I associated factor 53						rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	40333111	40333112	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40333111_40333112insT								FAM74A1 (425871 upstream) : FAM75A3 (367179 downstream)																																			---	---	---	---
ZNF658	26149	broad.mit.edu	37	9	40771888	40771888	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:40771888delT	uc004abs.2	-	5					ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_3'UTR	NM_033160	NP_149350			zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)														---	---	---	---
Unknown	0	broad.mit.edu	37	9	44078575	44078575	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:44078575delT								FAM75A6 (447845 upstream) : FAM27C (911661 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	66333430	66333430	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:66333430delA								FAM74A4 (839044 upstream) : LOC442421 (163040 downstream)																																			---	---	---	---
PIP5K1B	8395	broad.mit.edu	37	9	71555419	71555419	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:71555419delA	uc004agu.2	+						PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_003558	NP_003549			phosphatidylinositol-4-phosphate 5-kinase, type							endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)														---	---	---	---
MAMDC2	256691	broad.mit.edu	37	9	72832656	72832656	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72832656delA	uc004ahm.2	+						MAMDC2_uc004ahn.2_Intron|uc004ahq.1_Intron	NM_153267	NP_694999			MAM domain containing 2 precursor							endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2																		---	---	---	---
SMC5	23137	broad.mit.edu	37	9	72893651	72893651	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72893651delT	uc004ahr.2	+							NM_015110	NP_055925			SMC5 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
SMC5	23137	broad.mit.edu	37	9	72933303	72933305	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:72933303_72933305delAAA	uc004ahr.2	+						uc004ahs.1_5'Flank	NM_015110	NP_055925			SMC5 protein						DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TRPM6	140803	broad.mit.edu	37	9	77457275	77457275	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77457275delA	uc004ajl.1	-						TRPM6_uc004ajk.1_Intron|TRPM6_uc010mpb.1_Intron|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajn.1_Intron	NM_017662	NP_060132			transient receptor potential cation channel,						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	78808345	78808347	+	IGR	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78808345_78808347delAAA								PCSK5 (7 upstream) : RFK (192086 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	9	78917033	78917033	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:78917033delT								PCSK5 (108695 upstream) : RFK (83400 downstream)																																			---	---	---	---
VPS13A	23230	broad.mit.edu	37	9	79895287	79895288	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79895287_79895288insT	uc004akr.2	+						VPS13A_uc004akp.3_Intron|VPS13A_uc004akq.3_Intron|VPS13A_uc004aks.2_Intron	NM_033305	NP_150648			vacuolar protein sorting 13A isoform A						Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10																		---	---	---	---
VPS13A	23230	broad.mit.edu	37	9	79946860	79946860	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:79946860delT	uc004akr.2	+						VPS13A_uc004akp.3_Intron|VPS13A_uc004akq.3_Intron|VPS13A_uc004aks.2_Intron|VPS13A_uc004akt.2_Intron	NM_033305	NP_150648			vacuolar protein sorting 13A isoform A						Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10																		---	---	---	---
CEP78	84131	broad.mit.edu	37	9	80856594	80856594	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:80856594delT	uc004akx.2	+						CEP78_uc004aky.3_Intron|CEP78_uc010mpp.2_Intron|CEP78_uc011lsp.1_Intron	NM_032171	NP_115547			centrosomal protein 78kDa isoform b						G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	81651253	81651254	+	IGR	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:81651253_81651254delTT								PSAT1 (706246 upstream) : TLE4 (535624 downstream)																																			---	---	---	---
TLE1	7088	broad.mit.edu	37	9	84200354	84200354	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:84200354delT	uc004aly.2	-						TLE1_uc004alz.2_Intron|TLE1_uc011lsr.1_Intron	NM_005077	NP_005068			transducin-like enhancer protein 1						negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2																		---	---	---	---
TLE1	7088	broad.mit.edu	37	9	84248346	84248346	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:84248346delA	uc004aly.2	-						TLE1_uc004alz.2_Intron|TLE1_uc011lsr.1_Intron|TLE1_uc004ama.1_Intron|TLE1_uc011lss.1_Intron	NM_005077	NP_005068			transducin-like enhancer protein 1						negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2																		---	---	---	---
KIF27	55582	broad.mit.edu	37	9	86506112	86506112	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86506112delA	uc004ana.2	-						KIF27_uc010mpw.2_Intron|KIF27_uc010mpx.2_Intron	NM_017576	NP_060046			kinesin family member 27						cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5																		---	---	---	---
HNRNPK	3190	broad.mit.edu	37	9	86584096	86584096	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:86584096delC	uc004ang.3	-	17					HNRNPK_uc011lsw.1_3'UTR|HNRNPK_uc004and.3_3'UTR|HNRNPK_uc004ank.3_3'UTR|HNRNPK_uc004anf.3_3'UTR|HNRNPK_uc004anh.3_3'UTR|HNRNPK_uc011lsx.1_3'UTR|HNRNPK_uc004ani.3_3'UTR|HNRNPK_uc004anj.3_3'UTR|HNRNPK_uc004ann.3_3'UTR|HNRNPK_uc004anl.3_3'UTR|HNRNPK_uc004anm.3_3'UTR	NM_031262	NP_112552			heterogeneous nuclear ribonucleoprotein K						interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1																		---	---	---	---
NAA35	60560	broad.mit.edu	37	9	88618680	88618680	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88618680delT	uc004aoi.3	+						NAA35_uc004aoj.3_Intron	NM_024635	NP_078911			corneal wound healing-related protein						smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3																		---	---	---	---
GOLM1	51280	broad.mit.edu	37	9	88667264	88667264	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88667264delT	uc004aol.2	-						GOLM1_uc010mqd.1_Intron|GOLM1_uc004aom.2_Intron	NM_016548	NP_057632			golgi membrane protein 1							Golgi apparatus|integral to plasma membrane					0																		---	---	---	---
SPIN1	10927	broad.mit.edu	37	9	91077724	91077724	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91077724delT	uc010mqj.2	+						SPIN1_uc004apy.2_Intron|SPIN1_uc004apz.2_Intron|SPIN1_uc010mqk.2_Intron	NM_006717	NP_006708			spindlin						cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0																		---	---	---	---
SHC3	53358	broad.mit.edu	37	9	91628599	91628599	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:91628599delG	uc004aqg.2	-							NM_016848	NP_058544			src homology 2 domain-containing transforming						central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4																		---	---	---	---
ECM2	1842	broad.mit.edu	37	9	95268085	95268085	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95268085delT	uc004ash.2	-						CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Intron|ECM2_uc011lty.1_Intron|ECM2_uc004asg.2_Intron|ECM2_uc010mqz.1_Intron	NM_001393	NP_001384			extracellular matrix protein 2 precursor						cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2																		---	---	---	---
FGD3	89846	broad.mit.edu	37	9	95777920	95777920	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95777920delA	uc004asw.2	+						FGD3_uc004asx.2_Intron|FGD3_uc004asz.2_Intron|FGD3_uc004ata.2_Intron|FGD3_uc011luc.1_Intron	NM_001083536	NP_001077005			FYVE, RhoGEF and PH domain containing 3						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2																		---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96422612	96422612	+	Frame_Shift_Del	DEL	A	-	-	rs76832193		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96422612delA	uc004aub.2	+	12	1615	c.1468delA	c.(1468-1470)AAAfs	p.K490fs	PHF2_uc011lug.1_Frame_Shift_Del_p.K373fs|PHF2_uc004auc.2_5'Flank	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	490	Pro-rich.|Lys-rich.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96439794	96439794	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96439794delC	uc004aub.2	+						PHF2_uc004auc.2_Intron	NM_005392	NP_005383			PHD finger protein 2						liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---
PTPDC1	138639	broad.mit.edu	37	9	96864016	96864017	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96864016_96864017insT	uc004auf.1	+	8	2360_2361	c.2020_2021insT	c.(2020-2022)CTTfs	p.L674fs	PTPDC1_uc004aug.1_Frame_Shift_Ins_p.L669fs|PTPDC1_uc004auh.1_Frame_Shift_Ins_p.L726fs|PTPDC1_uc010mrj.1_Frame_Shift_Ins_p.L728fs	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	674							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	96941100	96941100	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96941100delA	uc004auk.2	-						uc004aul.1_5'Flank|MIRLET7D_hsa-let-7d|MI0000065_5'Flank					Homo sapiens cDNA clone IMAGE:5265295.																														---	---	---	---
FANCC	2176	broad.mit.edu	37	9	97934766	97934766	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:97934766delT	uc004avh.2	-						FANCC_uc004avi.3_Intron|FANCC_uc010mrm.1_Intron|FANCC_uc011lul.1_Intron	NM_000136	NP_000127			Fanconi anemia, complementation group C						protein complex assembly	cytosol|nucleoplasm	protein binding			kidney(1)	1		Acute lymphoblastic leukemia(62;0.138)						D|Mis|N|F|S			AML|leukemia		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
Unknown	0	broad.mit.edu	37	9	98910246	98910246	+	IGR	DEL	A	-	-	rs139074595		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98910246delA								NCRNA00092 (126209 upstream) : HSD17B3 (87343 downstream)																																			---	---	---	---
HEMGN	55363	broad.mit.edu	37	9	100700506	100700507	+	5'UTR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100700506_100700507delAA	uc004axy.2	-	1					HEMGN_uc004axz.2_Intron	NM_197978	NP_932095			hemogen						cell differentiation|multicellular organismal development					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
CORO2A	7464	broad.mit.edu	37	9	100892263	100892263	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:100892263delT	uc004ayl.2	-						CORO2A_uc004aym.2_Intron|CORO2A_uc004ayk.2_5'Flank	NM_003389	NP_003380			coronin, actin binding protein, 2A						actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
COL15A1	1306	broad.mit.edu	37	9	101814727	101814729	+	Intron	DEL	CTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101814727_101814729delCTT	uc004azb.1	+							NM_001855	NP_001846			alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---
COL15A1	1306	broad.mit.edu	37	9	101816826	101816826	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101816826delT	uc004azb.1	+							NM_001855	NP_001846			alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)																---	---	---	---
TGFBR1	7046	broad.mit.edu	37	9	101911437	101911437	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101911437delT	uc004azc.2	+						TGFBR1_uc004azd.2_Intron|TGFBR1_uc011lvc.1_Intron	NM_004612	NP_004603			transforming growth factor, beta receptor I						activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)																---	---	---	---
NR4A3	8013	broad.mit.edu	37	9	102595157	102595157	+	Intron	DEL	A	-	-	rs12004907		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:102595157delA	uc004baf.1	+						NR4A3_uc004bae.2_Intron|NR4A3_uc004bag.1_Intron|NR4A3_uc004bai.2_Intron	NM_006981	NP_008912			nuclear receptor subfamily 4, group A, member 3						regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)						T	EWSR1	extraskeletal myxoid chondrosarcoma								---	---	---	---
STX17	55014	broad.mit.edu	37	9	102677512	102677512	+	5'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:102677512delT	uc004bal.3	+	2					STX17_uc004bak.2_5'UTR|STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389			syntaxin 17						intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)																---	---	---	---
ERP44	23071	broad.mit.edu	37	9	102784638	102784639	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:102784638_102784639insA	uc004bam.2	-						ERP44_uc010msy.2_Intron|ERP44_uc010msz.2_Intron	NM_015051	NP_055866			thioredoxin domain containing 4 (endoplasmic						cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0																		---	---	---	---
TEX10	54881	broad.mit.edu	37	9	103072731	103072731	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103072731delT	uc004bas.2	-						TEX10_uc011lvf.1_Intron|TEX10_uc011lvg.1_Intron	NM_017746	NP_060216			testis expressed 10 isoform 1							integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)														---	---	---	---
TEX10	54881	broad.mit.edu	37	9	103082709	103082710	+	Intron	INS	-	A	A	rs28460607		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:103082709_103082710insA	uc004bas.2	-						TEX10_uc011lvf.1_Intron|TEX10_uc011lvg.1_Intron	NM_017746	NP_060216			testis expressed 10 isoform 1							integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)														---	---	---	---
SMC2	10592	broad.mit.edu	37	9	106885299	106885302	+	Intron	DEL	TTTA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:106885299_106885302delTTTA	uc004bbv.2	+						SMC2_uc004bbu.1_Intron|SMC2_uc004bbw.2_Intron|SMC2_uc011lvl.1_Intron|SMC2_uc004bbx.2_Intron	NM_001042551	NP_001036016			structural maintenance of chromosomes 2						cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9																		---	---	---	---
OR13C9	286362	broad.mit.edu	37	9	107380517	107380517	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:107380517delA	uc011lvr.1	-							NM_001001956	NP_001001956			olfactory receptor, family 13, subfamily C,						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
ABCA1	19	broad.mit.edu	37	9	107582009	107582009	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:107582009delA	uc004bcl.2	-							NM_005502	NP_005493			ATP-binding cassette, sub-family A member 1						Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
IKBKAP	8518	broad.mit.edu	37	9	111665955	111665955	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:111665955delA	uc004bdm.3	-						IKBKAP_uc004bdl.2_Intron|IKBKAP_uc011lwc.1_Intron|IKBKAP_uc010mtq.2_Intron	NM_003640	NP_003631			inhibitor of kappa light polypeptide gene						immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7																		---	---	---	---
EPB41L4B	54566	broad.mit.edu	37	9	112013643	112013643	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:112013643delA	uc004bdz.1	-						EPB41L4B_uc004bea.2_Intron	NM_019114	NP_061987			erythrocyte membrane protein band 4.1 like 4B							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
MUSK	4593	broad.mit.edu	37	9	113548015	113548015	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:113548015delA	uc004bey.2	+						MUSK_uc004bez.1_Intron	NM_005592	NP_005583			skeletal muscle receptor tyrosine kinase						transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114174440	114174440	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114174440delA	uc004bfe.1	-							NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
KIAA0368	23392	broad.mit.edu	37	9	114213851	114213851	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114213851delA	uc004bfe.1	-						KIAA0368_uc010muc.1_Intron	NM_001080398	NP_001073867			KIAA0368 protein												0																		---	---	---	---
ROD1	9991	broad.mit.edu	37	9	114985973	114985974	+	3'UTR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:114985973_114985974delAA	uc004bfw.2	-	15					ROD1_uc004bfv.2_3'UTR|ROD1_uc004bfx.2_3'UTR|ROD1_uc011lwu.1_3'UTR|ROD1_uc004bfy.2_3'UTR|ROD1_uc004bfz.2_Intron	NM_005156	NP_005147			ROD1 regulator of differentiation 1 isoform 1						anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1																		---	---	---	---
ZFP37	7539	broad.mit.edu	37	9	115806416	115806416	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:115806416delT	uc004bgm.1	-	4	510	c.482delA	c.(481-483)AATfs	p.N161fs	ZFP37_uc011lwz.1_Frame_Shift_Del_p.N176fs|ZFP37_uc011lxa.1_Frame_Shift_Del_p.N162fs	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	161						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
POLE3	54107	broad.mit.edu	37	9	116171195	116171195	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:116171195delT	uc011lxg.1	-	4	722	c.340delA	c.(340-342)ACAfs	p.T114fs	POLE3_uc004bhn.2_Frame_Shift_Del_p.T114fs|C9orf43_uc004bho.3_5'Flank|C9orf43_uc004bhp.2_5'Flank	NM_017443	NP_059139	Q9NRF9	DPOE3_HUMAN	DNA-directed DNA polymerase epsilon 3	114	Potential.				DNA replication|histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex	DNA-directed DNA polymerase activity|protein binding|sequence-specific DNA binding				0																		---	---	---	---
ASTN2	23245	broad.mit.edu	37	9	119942907	119942912	+	Intron	DEL	TTTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:119942907_119942912delTTTTTT	uc004bjs.1	-						ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjt.1_Intron|SNORA70C_uc011lxu.1_5'Flank	NM_198187	NP_937830			astrotactin 2 isoform c							integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9																		---	---	---	---
DBC1	1620	broad.mit.edu	37	9	121929281	121929282	+	3'UTR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:121929281_121929282insT	uc004bkc.2	-	8						NM_014618	NP_055433			deleted in bladder cancer 1 precursor						cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	123007117	123007118	+	IGR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123007117_123007118delAA								DBC1 (875378 upstream) : MIR147 (139 downstream)																																			---	---	---	---
CEP110	11064	broad.mit.edu	37	9	123916991	123916991	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123916991delT	uc004bkx.1	+						CEP110_uc004bla.1_Intron|CEP110_uc010mvo.1_Intron|CEP110_uc004blb.1_Intron|CEP110_uc010mvp.1_5'Flank	NM_007018	NP_008949			centrosomal protein 110kDa						cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0																		---	---	---	---
NDUFA8	4702	broad.mit.edu	37	9	124921881	124921881	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124921881delT	uc004blv.2	-						MORN5_uc011lyn.1_5'Flank|MORN5_uc004blw.2_5'Flank|MORN5_uc011lyo.1_5'Flank	NM_014222	NP_055037			NADH dehydrogenase (ubiquinone) 1 alpha						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1					NADH(DB00157)													---	---	---	---
LHX6	26468	broad.mit.edu	37	9	124971944	124971944	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:124971944delG	uc010mvw.2	-	8	1129	c.1020delC	c.(1018-1020)CCCfs	p.P340fs	LHX6_uc004blx.3_Frame_Shift_Del_p.P369fs|LHX6_uc004bly.3_Intron	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1	340					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
RC3H2	54542	broad.mit.edu	37	9	125618164	125618164	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125618164delA	uc010mwc.1	-						RC3H2_uc004bnc.2_Intron|RC3H2_uc004bnd.1_Intron|RC3H2_uc004bne.3_Intron	NM_001100588	NP_001094058			ring finger and CCCH-type zinc finger domains 2							cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4																		---	---	---	---
RABGAP1	23637	broad.mit.edu	37	9	125860247	125860247	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125860247delT	uc011lzh.1	+						RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzj.1_Intron	NM_012197	NP_036329			RAB GTPase activating protein 1						cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5																		---	---	---	---
PPP6C	5537	broad.mit.edu	37	9	127911822	127911822	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127911822delA	uc004bpg.3	-	7					PPP6C_uc010mwv.2_3'UTR|PPP6C_uc010mww.2_3'UTR|PPP6C_uc011lzr.1_3'UTR	NM_002721	NP_002712			protein phosphatase 6, catalytic subunit isoform						G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	9	127957481	127957481	+	IGR	DEL	A	-	-	rs79479616		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127957481delA								PPP6C (5263 upstream) : RABEPK (5336 downstream)																																			---	---	---	---
ZBTB43	23099	broad.mit.edu	37	9	129596298	129596299	+	3'UTR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:129596298_129596299delAA	uc004bql.2	+	3					ZBTB43_uc010mxf.2_3'UTR	NM_014007	NP_054726			zinc finger and BTB domain containing 43						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
LRSAM1	90678	broad.mit.edu	37	9	130236099	130236099	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130236099delC	uc004brb.1	+	11	984	c.639delC	c.(637-639)TACfs	p.Y213fs	LRSAM1_uc010mxk.1_Frame_Shift_Del_p.Y213fs|LRSAM1_uc004brc.1_Frame_Shift_Del_p.Y213fs|LRSAM1_uc004brd.1_Frame_Shift_Del_p.Y213fs	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	213					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
LRSAM1	90678	broad.mit.edu	37	9	130247868	130247868	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130247868delT	uc004brb.1	+						LRSAM1_uc010mxk.1_Intron|LRSAM1_uc004brc.1_Intron|LRSAM1_uc004brd.1_Intron|LRSAM1_uc004bre.1_Intron	NM_001005373	NP_001005373			leucine rich repeat and sterile alpha motif						negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0																		---	---	---	---
C9orf117	286207	broad.mit.edu	37	9	130476084	130476084	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130476084delC	uc004brn.1	+						PTRH1_uc004brm.2_Intron|C9orf117_uc010mxl.1_Intron|TTC16_uc004brq.1_5'Flank|TTC16_uc011mai.1_5'Flank	NM_001012502	NP_001012520			hypothetical protein LOC286207												0																		---	---	---	---
DNM1	1759	broad.mit.edu	37	9	130988258	130988260	+	Intron	DEL	CTC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130988258_130988260delCTC	uc011mau.1	+						DNM1_uc010mxr.2_Intron|DNM1_uc011mat.1_Intron	NM_004408	NP_004399			dynamin 1 isoform 1						receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2																		---	---	---	---
SPTAN1	6709	broad.mit.edu	37	9	131367238	131367242	+	Intron	DEL	TAAAT	-	-	rs149024655	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131367238_131367242delTAAAT	uc004bvl.3	+						SPTAN1_uc011mbh.1_Intron|SPTAN1_uc004bvm.3_Intron|SPTAN1_uc004bvn.3_Intron	NM_003127	NP_003118			spectrin, alpha, non-erythrocytic 1						actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10																		---	---	---	---
WDR34	89891	broad.mit.edu	37	9	131397627	131397627	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131397627delA	uc004bvq.1	-						WDR34_uc004bvs.1_Intron|WDR34_uc004bvr.1_Intron	NM_052844	NP_443076			WD repeat domain 34							cytoplasm				central_nervous_system(2)|skin(1)	3																OREG0019522	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NUP188	23511	broad.mit.edu	37	9	131711590	131711590	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131711590delT	uc004bws.1	+						NUP188_uc004bwq.1_Intron|DOLK_uc004bwr.2_5'Flank	NM_015354	NP_056169			nucleoporin 188kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7																		---	---	---	---
DOLPP1	57171	broad.mit.edu	37	9	131851408	131851408	+	3'UTR	DEL	T	-	-	rs79882748		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131851408delT	uc004bxc.2	+	8					DOLPP1_uc004bxd.2_3'UTR|DOLPP1_uc004bxe.2_RNA|DOLPP1_uc004bxf.2_3'UTR	NM_020438	NP_065171			dolichyl pyrophosphate phosphatase 1 isoform a						dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1																		---	---	---	---
C9orf98	158067	broad.mit.edu	37	9	135690206	135690206	+	Intron	DEL	A	-	-	rs140406073		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135690206delA	uc004cbu.1	-						C9orf98_uc010mzx.1_Intron|C9orf98_uc004cbv.1_Intron	NM_152572	NP_689785			putative adenylate kinase-like protein C9orf98							cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)														---	---	---	---
WDR5	11091	broad.mit.edu	37	9	137013309	137013319	+	Intron	DEL	TTTTTTTTTTT	-	-	rs36118398		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:137013309_137013319delTTTTTTTTTTT	uc004cey.2	+						WDR5_uc004cez.2_Intron	NM_017588	NP_060058			WD repeat domain 5						histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)														---	---	---	---
KIAA0649	9858	broad.mit.edu	37	9	138379043	138379043	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138379043delG	uc004cfr.1	+	4	3236	c.2687delG	c.(2686-2688)AGGfs	p.R896fs		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	896						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138594013	138594013	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138594013delA	uc011mdq.1	+						KCNT1_uc011mdr.1_5'Flank|KCNT1_uc010nbf.2_5'Flank|SOHLH1_uc010nbe.2_5'Flank|SOHLH1_uc004cgl.2_5'Flank	NM_020822	NP_065873			potassium channel, subfamily T, member 1							membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138648984	138648984	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138648984delC	uc011mdq.1	+						KCNT1_uc011mdr.1_Intron|KCNT1_uc010nbf.2_Intron|KCNT1_uc004cgo.1_Intron	NM_020822	NP_065873			potassium channel, subfamily T, member 1							membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
QSOX2	169714	broad.mit.edu	37	9	139107235	139107235	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139107235delG	uc010nbi.2	-							NM_181701	NP_859052			quiescin Q6 sulfhydryl oxidase 2 precursor						cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			ovary(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)														---	---	---	---
SNAPC4	6621	broad.mit.edu	37	9	139272220	139272220	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139272220delC	uc004chh.2	-	21	4068	c.4059delG	c.(4057-4059)GGGfs	p.G1353fs		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1353	SNAPC2-binding.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)														---	---	---	---
SNAPC4	6621	broad.mit.edu	37	9	139272275	139272275	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139272275delC	uc004chh.2	-	21	4013	c.4004delG	c.(4003-4005)GGCfs	p.G1335fs		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	1335	SNAPC2-binding.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)														---	---	---	---
MAMDC4	158056	broad.mit.edu	37	9	139750689	139750689	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139750689delC	uc004cjs.2	+						MAMDC4_uc011mej.1_Intron	NM_206920	NP_996803			apical early endosomal glycoprotein precursor						protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)														---	---	---	---
ABCA2	20	broad.mit.edu	37	9	139903560	139903560	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139903560delC	uc011mem.1	-						ABCA2_uc011mel.1_Intron|ABCA2_uc004ckl.1_Intron|ABCA2_uc004ckm.1_Intron	NM_001606	NP_001597			ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
ABCA2	20	broad.mit.edu	37	9	139917547	139917548	+	Intron	DEL	GA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139917547_139917548delGA	uc011mem.1	-						ABCA2_uc011mel.1_Intron|ABCA2_uc004ckl.1_Intron|ABCA2_uc004ckm.1_Intron|ABCA2_uc004cko.1_5'Flank|ABCA2_uc010nca.2_5'UTR	NM_001606	NP_001597			ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)														---	---	---	---
TUBB2C	10383	broad.mit.edu	37	9	140137090	140137091	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140137090_140137091insG	uc004cmh.1	+	4	522_523	c.420_421insG	c.(418-423)GGTGGGfs	p.G140fs	TUBB2C_uc004cmg.1_5'UTR	NM_006088	NP_006079	P68371	TBB2C_HUMAN	tubulin, beta, 2	140_141	GTP (Potential).				'de novo' posttranslational protein folding|cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding|structural molecule activity|unfolded protein binding			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)														---	---	---	---
PNPLA7	375775	broad.mit.edu	37	9	140396079	140396079	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140396079delC	uc004cnf.2	-						C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Intron	NM_152286	NP_689499			patatin-like phospholipase domain containing 7						lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)														---	---	---	---
WDR85	92715	broad.mit.edu	37	9	140468517	140468517	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140468517delA	uc004cnk.1	-						WDR85_uc004cnl.1_Intron|WDR85_uc004cnm.1_Intron|WDR85_uc004cnn.1_Intron	NM_138778	NP_620133			WD repeat domain 85						peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)														---	---	---	---
NET1	10276	broad.mit.edu	37	10	5495005	5495005	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5495005delT	uc001iia.2	+						NET1_uc010qar.1_Intron|NET1_uc001iib.2_Intron|NET1_uc010qas.1_Intron	NM_001047160	NP_001040625			neuroepithelial cell transforming gene 1 isoform						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1																		---	---	---	---
FBXO18	84893	broad.mit.edu	37	10	5950871	5950872	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:5950871_5950872insT	uc001iis.2	+						FBXO18_uc001iir.2_Intron|FBXO18_uc009xig.2_Intron|FBXO18_uc001iit.2_Intron	NM_178150	NP_835363			F-box only protein, helicase, 18 isoform 2						DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3																		---	---	---	---
ITIH2	3698	broad.mit.edu	37	10	7791036	7791036	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7791036delG	uc001ijs.2	+							NM_002216	NP_002207			inter-alpha globulin inhibitor H2 polypeptide						hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
TAF3	83860	broad.mit.edu	37	10	8055643	8055643	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:8055643delT	uc010qbd.1	+							NM_031923	NP_114129			RNA polymerase II transcription factor TAFII140						maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1																		---	---	---	---
USP6NL	9712	broad.mit.edu	37	10	11567611	11567611	+	Intron	DEL	T	-	-	rs77058930		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:11567611delT	uc001ikt.3	-						USP6NL_uc001iks.1_Intron	NM_014688	NP_055503			USP6 N-terminal like isoform 1							intracellular	Rab GTPase activator activity				0																		---	---	---	---
PHYH	5264	broad.mit.edu	37	10	13333804	13333804	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13333804delT	uc001imf.2	-						PHYH_uc001ime.2_Intron|PHYH_uc001img.2_Intron	NM_006214	NP_006205			phytanoyl-CoA 2-hydroxylase isoform a precursor						fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)													---	---	---	---
FRMD4A	55691	broad.mit.edu	37	10	14478507	14478507	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:14478507delG	uc001imv.2	-						FRMD4A_uc001imw.1_Intron|MIR1265_hsa-mir-1265|MI0006401_5'Flank					Homo sapiens mRNA for KIAA1294 protein, partial cds.							cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3																		---	---	---	---
FAM171A1	221061	broad.mit.edu	37	10	15262984	15262985	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15262984_15262985insG	uc001iob.2	-	6	836_837	c.829_830insC	c.(829-831)CAGfs	p.Q277fs		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	277	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4																		---	---	---	---
FAM188A	80013	broad.mit.edu	37	10	15831328	15831328	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:15831328delA	uc001iod.1	-						FAM188A_uc001ioe.1_Intron|FAM188A_uc001iof.1_Intron	NM_024948	NP_079224			chromosome 10 open reading frame 97						apoptosis	nucleus	calcium ion binding			ovary(1)	1																		---	---	---	---
CUBN	8029	broad.mit.edu	37	10	17083359	17083360	+	Intron	INS	-	TA	TA			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:17083359_17083360insTA	uc001ioo.2	-							NM_001081	NP_001072			cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)													---	---	---	---
NEBL	10529	broad.mit.edu	37	10	21148586	21148586	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21148586delA	uc001iqi.2	-						NEBL_uc001iqj.2_Intron|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384			nebulette sarcomeric isoform						regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2																		---	---	---	---
MLLT10	8028	broad.mit.edu	37	10	21958033	21958033	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:21958033delT	uc001iqs.2	+						MLLT10_uc001iqt.2_Intron|MLLT10_uc001iqv.2_Intron|MLLT10_uc001iqy.2_Intron|MLLT10_uc001ira.2_Intron|MLLT10_uc001iqz.2_Intron	NM_004641	NP_004632			myeloid/lymphoid or mixed-lineage leukemia						positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2								T	MLL|PICALM|CDK6	AL								---	---	---	---
DNAJC1	64215	broad.mit.edu	37	10	22209941	22209941	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22209941delA	uc001irc.2	-						DNAJC1_uc001ird.2_Intron	NM_022365	NP_071760			DnaJ (Hsp40) homolog, subfamily C, member 1						negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			lung(1)	1		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)																---	---	---	---
BMI1	648	broad.mit.edu	37	10	22617721	22617721	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22617721delA	uc001irh.2	+						BMI1_uc009xkg.2_Intron	NM_005180	NP_005171			BMI1 polycomb ring finger oncogene						hemopoiesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|positive regulation of ubiquitin-protein ligase activity|segment specification|transcription, DNA-dependent	cytoplasm|nucleolus|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
SPAG6	9576	broad.mit.edu	37	10	22690261	22690261	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:22690261delT	uc001iri.2	+						SPAG6_uc001irj.2_Intron|SPAG6_uc010qct.1_Intron|SPAG6_uc009xkh.2_Intron	NM_012443	NP_036575			sperm associated antigen 6 isoform 1						cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1																		---	---	---	---
ARHGAP21	57584	broad.mit.edu	37	10	24893317	24893317	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:24893317delA	uc001isb.2	-						ARHGAP21_uc010qdb.1_Intron|ARHGAP21_uc009xkl.1_Intron|ARHGAP21_uc010qdc.1_Intron	NM_020824	NP_065875			Rho GTPase activating protein 21						signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8																		---	---	---	---
WAC	51322	broad.mit.edu	37	10	28872533	28872533	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28872533delT	uc001iuf.2	+						WAC_uc001iud.2_Intron|WAC_uc001iue.2_Intron|WAC_uc009xlb.2_Intron|WAC_uc001iug.2_Intron|WAC_uc001iuh.2_Intron	NM_016628	NP_057712			WW domain-containing adapter with a coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
ZEB1	6935	broad.mit.edu	37	10	31791266	31791266	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:31791266delT	uc001ivs.3	+						ZEB1_uc001ivr.3_Intron|ZEB1_uc010qee.1_Intron|ZEB1_uc010qef.1_Intron|ZEB1_uc009xlh.1_Intron|ZEB1_uc009xli.1_Intron|ZEB1_uc009xlj.1_Intron|ZEB1_uc010qeg.1_Intron|ZEB1_uc009xlk.1_Intron|ZEB1_uc001ivt.3_Intron|ZEB1_uc001ivu.3_Intron|ZEB1_uc001ivv.3_Intron|ZEB1_uc010qeh.1_Intron|ZEB1_uc009xll.2_Intron|ZEB1_uc009xlm.1_Intron|ZEB1_uc009xln.1_Intron|ZEB1_uc009xlo.1_Intron|ZEB1_uc009xlp.2_Intron	NM_030751	NP_110378			zinc finger E-box binding homeobox 1 isoform b						cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	32391368	32391369	+	IGR	DEL	TT	-	-	rs78896224		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32391368_32391369delTT								KIF5B (45997 upstream) : EPC1 (166490 downstream)																																			---	---	---	---
CCDC7	221016	broad.mit.edu	37	10	32863477	32863477	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:32863477delT	uc001iwj.2	+	18					CCDC7_uc001iwk.2_3'UTR|CCDC7_uc009xlv.2_RNA|C10orf68_uc001iwl.1_Intron|C10orf68_uc001iwm.1_Intron|C10orf68_uc001iwn.3_Intron	NM_145023	NP_659460			coiled-coil domain containing 7												0		Breast(68;0.000207)|Prostate(175;0.0107)																---	---	---	---
C10orf68	79741	broad.mit.edu	37	10	33134724	33134725	+	Intron	INS	-	AC	AC	rs72229936		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33134724_33134725insAC	uc001iwn.3	+						C10orf68_uc001iwl.1_Intron|C10orf68_uc001iwm.1_Intron|C10orf68_uc010qei.1_Intron|C10orf68_uc001iwo.3_Intron	NM_024688	NP_078964			chromosome 10 open reading frame 68											skin(2)|ovary(1)	3																		---	---	---	---
NRP1	8829	broad.mit.edu	37	10	33552476	33552476	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:33552476delT	uc001iwx.3	-						NRP1_uc001iwv.3_Intron|NRP1_uc009xlz.2_Intron|NRP1_uc001iww.3_Intron|NRP1_uc001iwy.3_Intron|NRP1_uc001iwz.2_Intron|NRP1_uc001ixa.2_Intron|NRP1_uc001ixb.1_Intron|NRP1_uc001ixc.1_Intron	NM_003873	NP_003864			neuropilin 1 isoform a						axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)													---	---	---	---
PARD3	56288	broad.mit.edu	37	10	34625332	34625332	+	Intron	DEL	A	-	-	rs112315019		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:34625332delA	uc010qej.1	-						PARD3_uc010qek.1_Intron|PARD3_uc010qel.1_Intron|PARD3_uc010qem.1_Intron|PARD3_uc010qen.1_Intron|PARD3_uc010qeo.1_Intron|PARD3_uc010qep.1_Intron|PARD3_uc010qeq.1_Intron|PARD3_uc001ixo.1_Intron|PARD3_uc001ixp.1_Intron|PARD3_uc001ixq.1_Intron|PARD3_uc001ixr.1_Intron|PARD3_uc001ixt.1_Intron|PARD3_uc001ixu.1_Intron|PARD3_uc001ixs.1_Intron	NM_019619	NP_062565			partitioning-defective protein 3 homolog						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)																---	---	---	---
HSD17B7P2	158160	broad.mit.edu	37	10	38666843	38666843	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:38666843delT	uc001izq.2	+							NR_003086				Homo sapiens 17-beta-hydroxysteroid dehydrogenase type VII isoform mRNA, complete cds.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	10	39006565	39006565	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:39006565delT								LOC399744 (265485 upstream) : None (None downstream)																																			---	---	---	---
ZNF33B	7582	broad.mit.edu	37	10	43132292	43132292	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43132292delA	uc001jaf.1	-						ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Intron	NM_006955	NP_008886			zinc finger protein 33B							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
RET	5979	broad.mit.edu	37	10	43606526	43606526	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:43606526delG	uc001jal.2	+						RET_uc001jak.1_Intron|RET_uc010qez.1_Intron	NM_020975	NP_066124			ret proto-oncogene isoform a						homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				---	---	---	---
PTPN20B	26095	broad.mit.edu	37	10	46587300	46587300	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:46587300delA	uc001jdc.1	-						PTPN20B_uc001jcz.1_Intron|PTPN20B_uc001jda.1_Intron|PTPN20B_uc001jdb.1_Intron|PTPN20B_uc001jdd.1_Intron|PTPN20B_uc001jde.1_Intron|PTPN20B_uc001jdf.1_Intron|PTPN20B_uc001jdg.1_Intron|PTPN20B_uc001jdh.1_Intron|PTPN20B_uc001jdi.1_Intron|PTPN20B_uc009xmw.1_Intron|PTPN20B_uc001jdj.1_Intron|PTPN20B_uc009xmx.1_Intron|PTPN20B_uc001jdk.1_Intron|PTPN20B_uc001jdl.1_Intron|PTPN20B_uc001jdm.1_Intron|PTPN20B_uc001jdn.1_Intron|PTPN20B_uc001jdo.1_Intron|PTPN20B_uc001jdp.1_Intron|PTPN20B_uc001jdr.1_Intron|PTPN20B_uc001jdq.1_Intron|PTPN20B_uc001jds.1_Intron|PTPN20A_uc001jdt.1_Intron|PTPN20B_uc001jdu.1_Intron	NM_001042389	NP_001035848			protein tyrosine phosphatase, non-receptor type							microtubule|microtubule organizing center|nucleus	protein tyrosine phosphatase activity				0				Kidney(211;0.201)														---	---	---	---
FRMPD2	143162	broad.mit.edu	37	10	49400633	49400634	+	Intron	INS	-	A	A	rs75079659		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49400633_49400634insA	uc001jgi.2	-						FRMPD2_uc001jgh.2_Intron|FRMPD2_uc001jgj.2_Intron	NM_001018071	NP_001018081			FERM and PDZ domain containing 2 isoform 3						tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)														---	---	---	---
C10orf71	118461	broad.mit.edu	37	10	50532282	50532282	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50532282delC	uc010qgp.1	+	3	2031	c.1692delC	c.(1690-1692)GACfs	p.D564fs		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	564											0																		---	---	---	---
ERCC6	2074	broad.mit.edu	37	10	50701052	50701052	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50701052delA	uc001jhs.3	-						ERCC6_uc010qgr.1_Intron|ERCC6_uc001jhr.3_Intron	NM_000124	NP_000115			excision repair cross-complementing rodent						base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16													Direct_reversal_of_damage|NER					---	---	---	---
PARG	8505	broad.mit.edu	37	10	51584534	51584535	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51584534_51584535insA	uc001jih.2	-						uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Intron|NCOA4_uc010qhd.1_Intron|NCOA4_uc001jis.3_Intron|NCOA4_uc010qhe.1_Intron|NCOA4_uc010qhf.1_Intron|NCOA4_uc001jit.2_Intron|NCOA4_uc009xoo.2_Intron	NM_003631	NP_003622			poly (ADP-ribose) glycohydrolase						carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)														---	---	---	---
AGAP6	414189	broad.mit.edu	37	10	51768242	51768242	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51768242delT	uc001jix.3	+							NM_001077665	NP_001071133			ArfGAP with GTPase domain, ankyrin repeat and PH						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1																		---	---	---	---
PRKG1	5592	broad.mit.edu	37	10	54053536	54053536	+	Intron	DEL	A	-	-	rs68136289		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:54053536delA	uc001jjm.2	+						PRKG1_uc001jjo.2_Intron|PRKG1_uc009xow.1_Intron|uc001jjq.1_Intron	NM_001098512	NP_001091982			protein kinase, cGMP-dependent, type I isoform						actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)														---	---	---	---
PCDH15	65217	broad.mit.edu	37	10	55663180	55663180	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:55663180delA	uc001jju.1	-						PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Intron|PCDH15_uc010qhw.1_Intron|PCDH15_uc010qhx.1_Intron|PCDH15_uc010qhy.1_Intron|PCDH15_uc010qhz.1_Intron|PCDH15_uc010qia.1_Intron|PCDH15_uc010qib.1_Intron	NM_033056	NP_149045			protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)													HNSCC(58;0.16)			---	---	---	---
BICC1	80114	broad.mit.edu	37	10	60546935	60546935	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:60546935delA	uc001jki.1	+							NM_001080512	NP_001073981			bicaudal C homolog 1						multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61848192	61848192	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61848192delT	uc001jky.2	-						ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jla.1_Intron|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61894185	61894185	+	Intron	DEL	A	-	-	rs111779148		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61894185delA	uc001jky.2	-						ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jla.1_5'Flank|ANK3_uc001jlb.1_Intron	NM_020987	NP_066267			ankyrin 3 isoform 1						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
RTKN2	219790	broad.mit.edu	37	10	63958219	63958219	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63958219delA	uc001jlw.2	-						RTKN2_uc009xpf.1_Intron|RTKN2_uc001jlv.2_Intron	NM_145307	NP_660350			rhotekin 2						signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)																	---	---	---	---
RTKN2	219790	broad.mit.edu	37	10	64022583	64022583	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64022583delA	uc001jlw.2	-						ZNF365_uc001jly.3_Intron|RTKN2_uc001jlx.2_Intron	NM_145307	NP_660350			rhotekin 2						signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)																	---	---	---	---
ZNF365	22891	broad.mit.edu	37	10	64159513	64159513	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:64159513delA	uc001jly.3	+	5	1296	c.1234delA	c.(1234-1236)AAAfs	p.K412fs	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Frame_Shift_Del_p.K397fs|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)																	---	---	---	---
Unknown	0	broad.mit.edu	37	10	69634673	69634673	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69634673delA								DNAJC12 (36736 upstream) : SIRT1 (9754 downstream)																																			---	---	---	---
MYPN	84665	broad.mit.edu	37	10	69961538	69961539	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69961538_69961539delAA	uc001jnm.3	+						MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Intron|MYPN_uc009xpt.2_Intron|MYPN_uc010qit.1_Intron|MYPN_uc010qiu.1_Intron	NM_032578	NP_115967			myopalladin							nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5																		---	---	---	---
RUFY2	55680	broad.mit.edu	37	10	70136913	70136913	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70136913delT	uc001job.2	-						RUFY2_uc001jnz.1_Intron|RUFY2_uc001joa.2_5'UTR	NM_017987	NP_060457			RUN and FYVE domain-containing 2 isoform a							nucleus	metal ion binding			ovary(1)	1																		---	---	---	---
DNA2	1763	broad.mit.edu	37	10	70179448	70179448	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70179448delC	uc001jof.2	-						DNA2_uc001jog.1_Intron|DNA2_uc001joh.1_Intron	NM_001080449	NP_001073918			DNA replication helicase 2 homolog						base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0																		---	---	---	---
CCAR1	55749	broad.mit.edu	37	10	70497583	70497583	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70497583delT	uc001joo.2	+						CCAR1_uc001jol.1_Intron|CCAR1_uc001jom.1_Intron|CCAR1_uc009xpx.1_Intron|CCAR1_uc001jon.1_Intron|CCAR1_uc010qiz.1_Intron|CCAR1_uc010qja.1_Intron|CCAR1_uc010qjb.1_Intron	NM_018237	NP_060707			cell-cycle and apoptosis regulatory protein 1						apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7																		---	---	---	---
DDX21	9188	broad.mit.edu	37	10	70734599	70734599	+	Intron	DEL	A	-	-	rs5030902	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70734599delA	uc001jov.1	+						DDX21_uc001jow.1_Intron	NM_004728	NP_004719			DEAD (Asp-Glu-Ala-Asp) box polypeptide 21							nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3																		---	---	---	---
SUPV3L1	6832	broad.mit.edu	37	10	70947578	70947578	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:70947578delT	uc001jpe.1	+						SUPV3L1_uc010qjd.1_Intron	NM_003171	NP_003162			suppressor of var1, 3-like 1 precursor						DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2																		---	---	---	---
HK1	3098	broad.mit.edu	37	10	71060141	71060141	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71060141delT	uc001jpj.3	+						HK1_uc009xqc.1_Intron|HK1_uc001jpg.3_Intron|HK1_uc001jph.3_Intron|HK1_uc001jpi.3_Intron	NM_033500	NP_277035			hexokinase 1 isoform HKI-td						glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1																		---	---	---	---
HK1	3098	broad.mit.edu	37	10	71142131	71142131	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71142131delA	uc001jpl.3	+						HK1_uc001jpg.3_Intron|HK1_uc001jph.3_Intron|HK1_uc001jpi.3_Intron|HK1_uc001jpj.3_Intron|HK1_uc001jpk.3_Intron|HK1_uc009xqd.2_Intron	NM_000188	NP_000179			hexokinase 1 isoform HKI						glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1																		---	---	---	---
PPA1	5464	broad.mit.edu	37	10	71977532	71977532	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:71977532delA	uc001jqv.1	-							NM_021129	NP_066952			pyrophosphatase 1						diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(1)	1																		---	---	---	---
KIAA1274	27143	broad.mit.edu	37	10	72285941	72285941	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72285941delG	uc001jrd.3	+							NM_014431	NP_055246			KIAA1274											ovary(2)|central_nervous_system(1)	3																		---	---	---	---
SGPL1	8879	broad.mit.edu	37	10	72576785	72576786	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72576785_72576786insT	uc001jrm.2	+						SGPL1_uc001jrl.2_Intron	NM_003901	NP_003892			sphingosine-1-phosphate lyase 1						apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)													---	---	---	---
CCDC109A	90550	broad.mit.edu	37	10	74644015	74644015	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74644015delT	uc001jtc.2	+						CCDC109A_uc010qjy.1_Intron|CCDC109A_uc009xqr.2_Intron|CCDC109A_uc001jtd.2_Intron	NM_138357	NP_612366			coiled-coil domain containing 109A						elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)																	---	---	---	---
OIT3	170392	broad.mit.edu	37	10	74660043	74660043	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:74660043delC	uc001jte.1	+						OIT3_uc009xqs.1_Intron	NM_152635	NP_689848			oncoprotein-induced transcript 3 precursor							nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)																	---	---	---	---
TTC18	118491	broad.mit.edu	37	10	75072125	75072125	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75072125delA	uc009xrc.2	-						TTC18_uc001jty.2_Intron|TTC18_uc009xrd.1_Intron	NM_145170	NP_660153			tetratricopeptide repeat domain 18								binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)																	---	---	---	---
TTC18	118491	broad.mit.edu	37	10	75108073	75108073	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75108073delT	uc009xrc.2	-						TTC18_uc001jty.2_Intron|TTC18_uc009xrd.1_Intron	NM_145170	NP_660153			tetratricopeptide repeat domain 18								binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)																	---	---	---	---
ZMYND17	118490	broad.mit.edu	37	10	75182105	75182105	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75182105delT	uc001juc.2	-	6										RecName: Full=Zinc finger MYND domain-containing protein 17;								zinc ion binding			ovary(1)	1	Prostate(51;0.0119)																	---	---	---	---
USP54	159195	broad.mit.edu	37	10	75299152	75299153	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75299152_75299153delTT	uc001juo.2	-						USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Intron|USP54_uc010qkl.1_Intron|USP54_uc001juq.1_Intron	NM_152586	NP_689799			ubiquitin specific peptidase 54						ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)																	---	---	---	---
SEC24C	9632	broad.mit.edu	37	10	75525560	75525560	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75525560delC	uc001juw.2	+	11	1548	c.1369delC	c.(1369-1371)CCCfs	p.P457fs	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Frame_Shift_Del_p.P315fs|SEC24C_uc001jux.2_Frame_Shift_Del_p.P457fs|SEC24C_uc010qko.1_Frame_Shift_Del_p.P338fs|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	457					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)																	---	---	---	---
POLR3A	11128	broad.mit.edu	37	10	79759909	79759909	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:79759909delA	uc001jzn.2	-							NM_007055	NP_008986			polymerase (RNA) III (DNA directed) polypeptide						innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)															---	---	---	---
NRG3	10718	broad.mit.edu	37	10	83635238	83635238	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:83635238delC	uc001kco.2	+	1	169	c.142delC	c.(142-144)CCCfs	p.P48fs	NRG3_uc010qlz.1_Frame_Shift_Del_p.P48fs|NRG3_uc001kcp.2_5'Flank|NRG3_uc001kcq.2_5'Flank	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	48	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	85841638	85841638	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85841638delA								None (None upstream) : GHITM (57547 downstream)																																			---	---	---	---
C10orf99	387695	broad.mit.edu	37	10	85944311	85944311	+	Intron	DEL	A	-	-	rs147902550		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85944311delA	uc001kcu.2	+							NM_207373	NP_997256			hypothetical protein LOC387695 precursor							extracellular region				pancreas(1)	1																		---	---	---	---
GLUD1	2746	broad.mit.edu	37	10	88834259	88834260	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:88834259_88834260delAT	uc001keh.2	-						GLUD1_uc001keg.2_Intron|GLUD1_uc010qmp.1_Intron	NM_005271	NP_005262			glutamate dehydrogenase 1 precursor						glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)													---	---	---	---
PTEN	5728	broad.mit.edu	37	10	89725294	89725294	+	3'UTR	DEL	T	-	-	rs1044487		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:89725294delT	uc001kfb.2	+	10						NM_000314	NP_000305			phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)			31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			---	---	---	---
STAMBPL1	57559	broad.mit.edu	37	10	90682146	90682146	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90682146delA	uc001kfk.2	+	10	1630	c.1207delA	c.(1207-1209)AAAfs	p.K403fs	STAMBPL1_uc010qmx.1_Frame_Shift_Del_p.K403fs|STAMBPL1_uc009xto.2_RNA|STAMBPL1_uc001kfl.2_Frame_Shift_Del_p.K403fs|STAMBPL1_uc001kfn.2_Frame_Shift_Del_p.K237fs	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	403							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)														---	---	---	---
ACTA2	59	broad.mit.edu	37	10	90749357	90749357	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:90749357delA	uc001kfq.2	-						FAS_uc010qna.1_Intron|FAS_uc001kfr.2_5'Flank|FAS_uc001kfs.2_5'Flank|FAS_uc001kft.2_5'Flank|FAS_uc010qnb.1_5'Flank|FAS_uc010qnc.1_5'Flank|FAS_uc001kfw.2_5'Flank|FAS_uc010qnd.1_5'Flank|FAS_uc010qne.1_5'Flank|FAS_uc009xtp.2_5'Flank	NM_001141945	NP_001135417			alpha 2 actin						response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)														---	---	---	---
KIF20B	9585	broad.mit.edu	37	10	91478521	91478521	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:91478521delT	uc001kgs.1	+	12	1398	c.1326delT	c.(1324-1326)AGTfs	p.S442fs	KIF20B_uc001kgr.1_Frame_Shift_Del_p.S442fs	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	442					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
HECTD2	143279	broad.mit.edu	37	10	93258537	93258537	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93258537delA	uc001khl.2	+						LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Intron|HECTD2_uc001khm.2_Intron|HECTD2_uc009xty.1_Intron|HECTD2_uc001khn.1_Intron	NM_182765	NP_877497			HECT domain containing 2 isoform a						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1																		---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93711462	93711462	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93711462delT	uc001khr.2	+						BTAF1_uc009xua.1_Intron	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93722539	93722539	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93722539delT	uc001khr.2	+						BTAF1_uc001khs.1_Intron	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93748896	93748896	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93748896delT	uc001khr.2	+						BTAF1_uc001khs.1_Intron|BTAF1_uc001kht.1_Intron	NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
BTAF1	9044	broad.mit.edu	37	10	93770919	93770919	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93770919delT	uc001khr.2	+							NM_003972	NP_003963			BTAF1 RNA polymerase II, B-TFIID transcription						negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)																---	---	---	---
CYP26A1	1592	broad.mit.edu	37	10	94833853	94833854	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94833853_94833854insG	uc001kil.2	+	1	207_208	c.162_163insG	c.(160-165)TTTGGGfs	p.F54fs	CYP26A1_uc001kik.1_Intron|CYP26A1_uc001kim.1_5'Flank	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	54_55					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	94968105	94968105	+	IGR	DEL	T	-	-	rs76646378		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94968105delT								CYP26A1 (130464 upstream) : MYOF (98082 downstream)																																			---	---	---	---
MYOF	26509	broad.mit.edu	37	10	95157050	95157050	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95157050delA	uc001kin.2	-						MYOF_uc001kio.2_Intron|MYOF_uc001kip.3_Intron|MYOF_uc009xuf.2_Intron	NM_013451	NP_038479			myoferlin isoform a						blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4																		---	---	---	---
PDE6C	5146	broad.mit.edu	37	10	95415397	95415397	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95415397delA	uc001kiu.3	+							NM_006204	NP_006195			phosphodiesterase 6C						visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)																---	---	---	---
LGI1	9211	broad.mit.edu	37	10	95537108	95537109	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95537108_95537109insT	uc001kjc.3	+						LGI1_uc010qnv.1_Intron|LGI1_uc001kjd.3_Intron|LGI1_uc009xui.2_Intron|LGI1_uc001kje.2_Intron	NM_005097	NP_005088			leucine-rich, glioma inactivated 1 precursor						axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)																---	---	---	---
PLCE1	51196	broad.mit.edu	37	10	95987002	95987002	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:95987002delA	uc001kjk.2	+						PLCE1_uc010qnx.1_Intron|PLCE1_uc001kjm.2_Intron	NM_016341	NP_057425			phospholipase C, epsilon 1 isoform 1						activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)																---	---	---	---
C10orf129	142827	broad.mit.edu	37	10	96979507	96979507	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:96979507delT	uc001kke.2	+						C10orf129_uc009xuu.1_Intron	NM_207321	NP_997204			acyl-coenzyme A synthetase ACSM6, mitochondrial						fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding				0		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)														---	---	---	---
DNTT	1791	broad.mit.edu	37	10	98088357	98088357	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98088357delA	uc001kmf.2	+						DNTT_uc001kmg.2_Intron	NM_004088	NP_004079			terminal deoxynucleotidyltransferase isoform 1						DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)														---	---	---	---
PIK3AP1	118788	broad.mit.edu	37	10	98376420	98376421	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:98376420_98376421delTC	uc001kmq.2	-	13	2117_2118	c.1989_1990delGA	c.(1987-1992)GAGAAGfs	p.E663fs	PIK3AP1_uc001kmo.2_Frame_Shift_Del_p.E262fs|PIK3AP1_uc001kmp.2_Frame_Shift_Del_p.E485fs	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	663_664	Potential.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)														---	---	---	---
MMS19	64210	broad.mit.edu	37	10	99221731	99221731	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99221731delA	uc001kns.3	-						MMS19_uc001knq.2_5'Flank|MMS19_uc009xvs.2_Intron|MMS19_uc009xvt.2_Intron|MMS19_uc001knr.2_Intron|MMS19_uc010qox.1_Intron|MMS19_uc001knt.2_Intron|MMS19_uc001knu.1_Intron	NM_022362	NP_071757			MMS19 nucleotide excision repair homolog						chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity				0		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)									Direct_reversal_of_damage|NER					---	---	---	---
ABCC2	1244	broad.mit.edu	37	10	101554088	101554088	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101554088delA	uc001kqf.2	+							NM_000392	NP_000383			ATP-binding cassette, sub-family C (CFTR/MRP),							apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)													---	---	---	---
CPN1	1369	broad.mit.edu	37	10	101808458	101808458	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101808458delA	uc001kql.2	-							NM_001308	NP_001299			carboxypeptidase N, polypeptide 1 precursor						proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)														---	---	---	---
CHUK	1147	broad.mit.edu	37	10	101978697	101978697	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:101978697delA	uc001kqp.2	-							NM_001278	NP_001269			conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)														---	---	---	---
FAM178A	55719	broad.mit.edu	37	10	102721626	102721626	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102721626delT	uc001krt.3	+							NM_018121	NP_060591			hypothetical protein LOC55719 isoform 1												0																		---	---	---	---
GBF1	8729	broad.mit.edu	37	10	104140752	104140752	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104140752delA	uc001kux.1	+						GBF1_uc001kuy.1_Intron|GBF1_uc001kuz.1_Intron	NM_004193	NP_004184			golgi-specific brefeldin A resistant guanine						COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)														---	---	---	---
PDCD11	22984	broad.mit.edu	37	10	105169424	105169424	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:105169424delT	uc001kwy.1	+							NM_014976	NP_055791			programmed cell death 11						mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)														---	---	---	---
CCDC147	159686	broad.mit.edu	37	10	106214015	106214016	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:106214015_106214016insT	uc001kyh.2	+							NM_001008723	NP_001008723			coiled-coil domain containing 147											ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)														---	---	---	---
Unknown	0	broad.mit.edu	37	10	109362642	109362644	+	IGR	DEL	CTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:109362642_109362644delCTT								SORCS1 (438350 upstream) : None (None downstream)																																			---	---	---	---
XPNPEP1	7511	broad.mit.edu	37	10	111651337	111651337	+	Intron	DEL	T	-	-	rs112429910		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111651337delT	uc001kyp.1	-						XPNPEP1_uc009xxt.1_Intron|XPNPEP1_uc001kyq.1_Intron|XPNPEP1_uc010qrb.1_Intron	NM_020383	NP_065116			X-prolyl aminopeptidase (aminopeptidase P) 1,						bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			ovary(3)|pancreas(1)	4		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)														---	---	---	---
MXI1	4601	broad.mit.edu	37	10	111967927	111967928	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111967927_111967928insC	uc001kyy.2	+						MXI1_uc001kyz.2_5'Flank	NM_130439	NP_569157			MAX interactor 1 isoform b						cytoplasmic sequestering of transcription factor|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;1.33e-05)|all cancers(201;0.000277)|BRCA - Breast invasive adenocarcinoma(275;0.127)														---	---	---	---
SHOC2	8036	broad.mit.edu	37	10	112769710	112769711	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112769710_112769711delTT	uc001kzl.3	+						SHOC2_uc009xxx.2_Intron|SHOC2_uc010qrg.1_Intron|SHOC2_uc001kzn.2_Intron	NM_007373	NP_031399			soc-2 suppressor of clear homolog						fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)														---	---	---	---
ACSL5	51703	broad.mit.edu	37	10	114187211	114187211	+	3'UTR	DEL	T	-	-	rs77356064		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114187211delT	uc001kzs.2	+	21					ACSL5_uc001kzt.2_3'UTR|ACSL5_uc001kzu.2_3'UTR|ACSL5_uc009xxz.2_3'UTR|ACSL5_uc010qrj.1_3'UTR	NM_203379	NP_976313			acyl-CoA synthetase long-chain family member 5						fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)														---	---	---	---
VTI1A	143187	broad.mit.edu	37	10	114297977	114297977	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:114297977delT	uc001kzy.2	+						VTI1A_uc001kzz.2_Intron	NM_145206	NP_660207			SNARE Vti1a-beta protein						intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity			ovary(1)	1		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)														---	---	---	---
CASP7	840	broad.mit.edu	37	10	115489357	115489357	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115489357delT	uc001lan.2	+	7					CASP7_uc001lam.2_3'UTR|CASP7_uc001lao.2_3'UTR|CASP7_uc001lap.2_3'UTR|CASP7_uc001laq.2_3'UTR|CASP7_uc010qsa.1_3'UTR|CASP7_uc010qsb.1_3'UTR	NM_033339	NP_203125			caspase 7 isoform alpha						activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)														---	---	---	---
FAM160B1	57700	broad.mit.edu	37	10	116603072	116603072	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116603072delT	uc001lcb.2	+						FAM160B1_uc001lcc.2_Intron	NM_020940	NP_065991			hypothetical protein LOC57700 isoform a											lung(1)	1																		---	---	---	---
TRUB1	142940	broad.mit.edu	37	10	116730223	116730223	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:116730223delA	uc001lcd.2	+						TRUB1_uc010qsl.1_Intron	NM_139169	NP_631908			TruB pseudouridine (psi) synthase homolog 1						pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)														---	---	---	---
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396277	+	Intron	DEL	G	-	-	rs148140777	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118396277delG	uc001lcq.2	+						PNLIPRP2_uc009xyv.1_Intron	NM_005396	NP_005387			pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)														---	---	---	---
KIAA1598	57698	broad.mit.edu	37	10	118661341	118661342	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118661341_118661342insG	uc009xyw.2	-	16	2105_2106	c.1607_1608insC	c.(1606-1608)CCAfs	p.P536fs	KIAA1598_uc001lcz.3_Intron|KIAA1598_uc010qso.1_Frame_Shift_Ins_p.P476fs|KIAA1598_uc010qsp.1_Frame_Shift_Ins_p.P536fs|KIAA1598_uc010qsq.1_Frame_Shift_Ins_p.P476fs|KIAA1598_uc001lcy.3_Frame_Shift_Ins_p.P506fs	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	536					axon guidance	axon					0				all cancers(201;0.00494)														---	---	---	---
KIAA1598	57698	broad.mit.edu	37	10	118689527	118689527	+	Intron	DEL	A	-	-	rs147242090	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118689527delA	uc009xyw.2	-						KIAA1598_uc001lcz.3_Intron|KIAA1598_uc010qso.1_Intron|KIAA1598_uc010qsp.1_Intron|KIAA1598_uc010qsq.1_Intron|KIAA1598_uc001lcy.3_Intron	NM_001127211	NP_001120683			shootin1 isoform a						axon guidance	axon					0				all cancers(201;0.00494)														---	---	---	---
C10orf46	143384	broad.mit.edu	37	10	120445457	120445461	+	3'UTR	DEL	TTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:120445457_120445461delTTTTT	uc001lds.1	-	9					C10orf46_uc010qst.1_Intron	NM_153810	NP_722517			chromosome 10 open reading frame 46						ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding				0		Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0131)														---	---	---	---
INPP5F	22876	broad.mit.edu	37	10	121566037	121566037	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:121566037delT	uc001leo.2	+							NM_014937	NP_055752			inositol polyphosphate-5-phosphatase F								phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)														---	---	---	---
WDR11	55717	broad.mit.edu	37	10	122630878	122630878	+	Intron	DEL	T	-	-	rs111818084		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:122630878delT	uc010qtf.1	+						WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_Intron	NM_018117	NP_060587			bromodomain and WD repeat domain containing 2							integral to membrane					0																		---	---	---	---
BTBD16	118663	broad.mit.edu	37	10	124097513	124097514	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124097513_124097514insT	uc001lgc.1	+						BTBD16_uc001lgd.1_Intron	NM_144587	NP_653188			BTB (POZ) domain containing 16											skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)																---	---	---	---
DMBT1	1755	broad.mit.edu	37	10	124384913	124384914	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124384913_124384914insG	uc001lgk.1	+						DMBT1_uc001lgl.1_Intron|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Intron|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yab.1_Intron|DMBT1_uc009yac.1_Intron	NM_007329	NP_015568			deleted in malignant brain tumors 1 isoform b						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)																---	---	---	---
OAT	4942	broad.mit.edu	37	10	126100485	126100485	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126100485delT	uc001lhp.2	-						OAT_uc001lhq.2_Intron|OAT_uc001lhr.2_Intron	NM_000274	NP_000265			ornithine aminotransferase precursor						cellular amino acid biosynthetic process|visual perception	mitochondrial matrix	ornithine-oxo-acid transaminase activity|protein binding|pyridoxal phosphate binding				0		all_lung(145;0.0271)|Lung NSC(174;0.0436)|Colorectal(57;0.102)|all_neural(114;0.116)			L-Ornithine(DB00129)|Pyridoxal Phosphate(DB00114)													---	---	---	---
C10orf90	118611	broad.mit.edu	37	10	128193320	128193320	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:128193320delG	uc001ljq.2	-	3	570	c.449delC	c.(448-450)CCAfs	p.P150fs	C10orf90_uc001ljp.2_Frame_Shift_Del_p.P103fs|C10orf90_uc010qum.1_Frame_Shift_Del_p.P247fs|C10orf90_uc009yao.2_Frame_Shift_Del_p.P247fs|C10orf90_uc001ljs.1_Frame_Shift_Del_p.P103fs	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	150										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)												OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DOCK1	1793	broad.mit.edu	37	10	129245705	129245705	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129245705delC	uc001ljt.2	+	51	5462	c.5398delC	c.(5398-5400)CCCfs	p.P1800fs	DOCK1_uc010qun.1_Frame_Shift_Del_p.P1821fs|DOCK1_uc009yaq.2_Frame_Shift_Del_p.T799fs|DOCK1_uc001ljw.1_5'Flank	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1800	SH3-binding; interaction with CRK (Potential).|Interaction with NCK2 second and third SH3 domain (minor).				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)														---	---	---	---
VENTX	27287	broad.mit.edu	37	10	135051672	135051672	+	Intron	DEL	G	-	-	rs112963779		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135051672delG	uc010quy.1	+							NM_014468	NP_055283			VENT homeobox						multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)														---	---	---	---
PTDSS2	81490	broad.mit.edu	37	11	486855	486855	+	Intron	DEL	T	-	-	rs55961417	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:486855delT	uc001lpj.2	+							NM_030783	NP_110410			phosphatidylserine synthase 2							integral to membrane					0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)													---	---	---	---
TNNI2	7136	broad.mit.edu	37	11	1861691	1861691	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1861691delG	uc010qxe.1	+						TNNI2_uc010qxc.1_Intron|TNNI2_uc010qxd.1_Intron	NM_001145841	NP_001139313			fast-twitch skeletal muscle troponin I isoform						muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)														---	---	---	---
ZNF195	7748	broad.mit.edu	37	11	3392733	3392733	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3392733delA	uc001lxt.2	-						ZNF195_uc001lxv.2_Intron|ZNF195_uc001lxs.2_Intron|ZNF195_uc010qxr.1_Intron|ZNF195_uc009ydz.2_Intron|ZNF195_uc001lxu.2_Intron	NM_001130520	NP_001123992			zinc finger protein 195 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)														---	---	---	---
NUP98	4928	broad.mit.edu	37	11	3742083	3742083	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3742083delA	uc001lyh.2	-						NUP98_uc001lyi.2_Intron|NUP98_uc001lyj.1_Intron|NUP98_uc001lyk.1_Intron	NM_016320	NP_057404			nucleoporin 98kD isoform 1						carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)				T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								---	---	---	---
STIM1	6786	broad.mit.edu	37	11	3944005	3944005	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3944005delA	uc001lyv.2	+						STIM1_uc009yef.2_Intron	NM_003156	NP_003147			stromal interaction molecule 1 precursor						activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			pancreas(1)	1		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)														---	---	---	---
RRM1	6240	broad.mit.edu	37	11	4141256	4141256	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4141256delT	uc001lyw.3	+						RRM1_uc009yej.2_Intron|RRM1_uc009yei.2_Intron|RRM1_uc010qyc.1_Intron|RRM1_uc010qyd.1_Intron	NM_001033	NP_001024			ribonucleoside-diphosphate reductase M1 chain						deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)													---	---	---	---
TPP1	1200	broad.mit.edu	37	11	6636199	6636199	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6636199delC	uc001mel.1	-	12	1510	c.1449delG	c.(1447-1449)GGGfs	p.G483fs	TAF10_uc001mej.1_5'Flank|TPP1_uc001mek.1_Frame_Shift_Del_p.G240fs	NM_000391	NP_000382	O14773	TPP1_HUMAN	tripeptidyl-peptidase I preproprotein	483					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)														---	---	---	---
NLRP14	338323	broad.mit.edu	37	11	7092311	7092311	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7092311delT	uc001mfb.1	+							NM_176822	NP_789792			NLR family, pyrin domain containing 14						cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)														---	---	---	---
RPL27A	6157	broad.mit.edu	37	11	8705732	8705732	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:8705732delT	uc001mgs.3	+						SNORA3_uc001mgq.1_5'Flank|SNORA45_uc001mgr.1_5'Flank	NM_000990	NP_000981			ribosomal protein L27a						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				Epithelial(150;3.24e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
TMEM41B	440026	broad.mit.edu	37	11	9308018	9308018	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9308018delA	uc001mhm.2	-	6	998	c.690delT	c.(688-690)TTTfs	p.F230fs	TMEM41B_uc001mhn.1_Frame_Shift_Del_p.F230fs	NM_015012	NP_055827	Q5BJD5	TM41B_HUMAN	transmembrane protein 41B isoform 1	230	Helical; (Potential).					integral to membrane					0				all cancers(16;9.96e-08)|Epithelial(150;4.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0972)														---	---	---	---
ZNF143	7702	broad.mit.edu	37	11	9500222	9500223	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:9500222_9500223insA	uc001mhr.2	+						ZNF143_uc009yfu.2_Intron|ZNF143_uc010rby.1_Intron	NM_003442	NP_003433			zinc finger protein 143						regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)														---	---	---	---
USP47	55031	broad.mit.edu	37	11	11951563	11951564	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:11951563_11951564insA	uc001mjq.1	+						USP47_uc001mjr.2_Intron|USP47_uc001mjs.2_Intron	NM_017944	NP_060414			ubiquitin specific protease 47						base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)														---	---	---	---
COPB1	1315	broad.mit.edu	37	11	14490716	14490716	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:14490716delT	uc001mli.2	-						COPB1_uc001mlg.2_Intron|COPB1_uc001mlh.2_Intron	NM_016451	NP_057535			coatomer protein complex, subunit beta 1						COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
RPS13	6207	broad.mit.edu	37	11	17099127	17099127	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17099127delC	uc001mmp.2	-							NM_001017	NP_001008			ribosomal protein S13						endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0																		---	---	---	---
PIK3C2A	5286	broad.mit.edu	37	11	17143576	17143579	+	Intron	DEL	AAAA	-	-	rs77774534		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17143576_17143579delAAAA	uc001mmq.3	-						PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636			phosphoinositide-3-kinase, class 2 alpha						cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)													---	---	---	---
LDHAL6A	160287	broad.mit.edu	37	11	18500107	18500107	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18500107delA	uc001mop.1	+						LDHAL6A_uc001moq.2_Intron	NM_001144071	NP_001137543			lactate dehydrogenase A-like 6A						glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)													---	---	---	---
ZDHHC13	54503	broad.mit.edu	37	11	19167708	19167708	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19167708delT	uc001mpi.2	+						ZDHHC13_uc001mpj.2_Intron	NM_019028	NP_061901			zinc finger, DHHC domain containing 13 isoform						positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding				0																		---	---	---	---
ZDHHC13	54503	broad.mit.edu	37	11	19174327	19174327	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19174327delT	uc001mpi.2	+						ZDHHC13_uc001mpj.2_Intron	NM_019028	NP_061901			zinc finger, DHHC domain containing 13 isoform						positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding				0																		---	---	---	---
ANO5	203859	broad.mit.edu	37	11	22261301	22261301	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:22261301delT	uc001mqi.2	+						ANO5_uc001mqj.2_Intron	NM_213599	NP_998764			anoctamin 5 isoform a							chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
LUZP2	338645	broad.mit.edu	37	11	24936024	24936024	+	Frame_Shift_Del	DEL	A	-	-	rs140841896		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:24936024delA	uc001mqs.2	+	7	696	c.462delA	c.(460-462)TCAfs	p.S154fs	LUZP2_uc009yif.2_Frame_Shift_Del_p.S68fs|LUZP2_uc009yig.2_Intron	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	154	Potential.					extracellular region				ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	29748140	29748140	+	IGR	DEL	A	-	-	rs140898794		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:29748140delA								None (None upstream) : KCNA4 (283626 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	11	30914661	30914662	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30914661_30914662insA	uc001mss.1	-						uc009yjk.1_Intron|uc009yjj.1_Intron					Homo sapiens mRNA for KIAA1493 protein, partial cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	11	30932783	30932783	+	Intron	DEL	T	-	-	rs72110565		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30932783delT	uc001mss.1	-						uc009yjk.1_Intron					Homo sapiens mRNA for KIAA1493 protein, partial cds.																														---	---	---	---
PRRG4	79056	broad.mit.edu	37	11	32852020	32852021	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:32852020_32852021delTT	uc001mtx.2	+							NM_024081	NP_076986			proline rich Gla (G-carboxyglutamic acid) 4							extracellular region|Golgi apparatus|integral to membrane	calcium ion binding				0	Breast(20;0.206)																	---	---	---	---
CSTF3	1479	broad.mit.edu	37	11	33130000	33130000	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33130000delT	uc001muh.2	-							NM_001326	NP_001317			cleavage stimulation factor subunit 3 isoform 1						mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0																		---	---	---	---
C11orf41	25758	broad.mit.edu	37	11	33628317	33628318	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:33628317_33628318insC	uc001mup.3	+	13	4261_4262	c.4137_4138insC	c.(4135-4140)GTGCCCfs	p.V1379fs		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1373_1374						integral to membrane				ovary(2)	2																		---	---	---	---
CAT	847	broad.mit.edu	37	11	34482536	34482536	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34482536delA	uc001mvm.2	+						CAT_uc009ykc.1_Intron|CAT_uc001mvn.2_5'Flank	NM_001752	NP_001743			catalase						hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)													---	---	---	---
CAT	847	broad.mit.edu	37	11	34490058	34490059	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:34490058_34490059delAA	uc001mvm.2	+						CAT_uc001mvn.2_Intron	NM_001752	NP_001743			catalase						hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			ovary(2)|pancreas(1)	3		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)													---	---	---	---
LRRC4C	57689	broad.mit.edu	37	11	40135879	40135879	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:40135879delT	uc001mxa.1	-	2					LRRC4C_uc001mxc.1_3'UTR|LRRC4C_uc001mxd.1_3'UTR|LRRC4C_uc001mxb.1_3'UTR	NM_020929	NP_065980			netrin-G1 ligand precursor						regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)																---	---	---	---
DGKZ	8525	broad.mit.edu	37	11	46394093	46394093	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46394093delG	uc001ncn.1	+						DGKZ_uc001nch.1_Intron|DGKZ_uc010rgq.1_Intron|DGKZ_uc001ncj.1_Intron|DGKZ_uc010rgr.1_Intron|DGKZ_uc001nck.1_Intron|DGKZ_uc001ncl.2_Intron|DGKZ_uc001ncm.2_Intron|DGKZ_uc009yky.1_Intron|DGKZ_uc010rgs.1_Intron	NM_001105540	NP_001099010			diacylglycerol kinase zeta isoform 4						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)														---	---	---	---
CKAP5	9793	broad.mit.edu	37	11	46799029	46799029	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46799029delT	uc001ndi.1	-	23	2932	c.2822delA	c.(2821-2823)AATfs	p.N941fs	CKAP5_uc009ylg.1_Frame_Shift_Del_p.N827fs|CKAP5_uc001ndj.1_Frame_Shift_Del_p.N941fs	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	941	HEAT 6.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	47212651	47212651	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47212651delA								PACSIN3 (4693 upstream) : DDB2 (23842 downstream)																																			---	---	---	---
ACP2	53	broad.mit.edu	37	11	47266084	47266085	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47266084_47266085insT	uc001nei.2	-						ACP2_uc010rhe.1_Intron|ACP2_uc009ylj.2_Intron|ACP2_uc010rhf.1_Intron|ACP2_uc010rhg.1_Intron|ACP2_uc010rhh.1_Intron|ACP2_uc010rhi.1_Intron|ACP2_uc009ylk.2_Intron	NM_001610	NP_001601			acid phosphatase 2, lysosomal isoform 1							integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1																		---	---	---	---
MTCH2	23788	broad.mit.edu	37	11	47657242	47657242	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:47657242delT	uc010rho.1	-						MTCH2_uc001nge.2_Intron|MTCH2_uc010rhp.1_Intron	NM_014342	NP_055157			mitochondrial carrier 2						transport	integral to membrane|mitochondrial inner membrane					0																		---	---	---	---
PTPRJ	5795	broad.mit.edu	37	11	48177275	48177276	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48177275_48177276insT	uc001ngp.3	+							NM_002843	NP_002834			protein tyrosine phosphatase, receptor type, J						contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	48441736	48441737	+	IGR	DEL	TT	-	-	rs147108249		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48441736_48441737delTT								OR4C45 (67737 upstream) : OR4A47 (68608 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	11	48967951	48967951	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:48967951delA								OR4A47 (456679 upstream) : FOLH1 (200237 downstream)																																			---	---	---	---
FOLH1	2346	broad.mit.edu	37	11	49192977	49192977	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49192977delT	uc001ngy.2	-						FOLH1_uc001ngz.2_Intron|FOLH1_uc009yly.2_Intron|FOLH1_uc009ylz.2_Intron|FOLH1_uc009yma.2_Intron	NM_004476	NP_004467			folate hydrolase 1 isoform 1						proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)													---	---	---	---
Unknown	0	broad.mit.edu	37	11	49896454	49896454	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:49896454delT								LOC440040 (64487 upstream) : OR4C13 (77521 downstream)																																			---	---	---	---
TRIM48	79097	broad.mit.edu	37	11	55035952	55035952	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55035952delT	uc010rid.1	+							NM_024114	NP_077019			tripartite motif-containing 48							intracellular	zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	55061270	55061270	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55061270delA	uc001nhl.1	-											Homo sapiens mRNA for hypothetical protein, partial sequence, clone:Hsa11-digit20-11-30-F.																														---	---	---	---
SPRYD5	84767	broad.mit.edu	37	11	55653610	55653610	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:55653610delA	uc010rip.1	+	3	515	c.423delA	c.(421-423)CTAfs	p.L141fs	SPRYD5_uc010riq.1_5'UTR	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	141						intracellular	zinc ion binding				0		all_epithelial(135;0.226)																---	---	---	---
OR5T3	390154	broad.mit.edu	37	11	56019846	56019847	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:56019846_56019847insT	uc010rjd.1	+	1	171_172	c.171_172insT	c.(169-174)CTATTTfs	p.L57fs		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	57_58	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)																	---	---	---	---
GIF	2694	broad.mit.edu	37	11	59599272	59599272	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:59599272delA	uc001noi.2	-							NM_005142	NP_005133			gastric intrinsic factor (vitamin B synthesis)						cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			ovary(1)|liver(1)	2																		---	---	---	---
MS4A14	84689	broad.mit.edu	37	11	60182852	60182852	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60182852delA	uc001npj.2	+						MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_Intron|MS4A14_uc001npk.2_Intron|MS4A14_uc001npl.2_Intron|MS4A14_uc001npm.2_Intron	NM_032597	NP_115986			membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			breast(1)	1																		---	---	---	---
CD6	923	broad.mit.edu	37	11	60783054	60783054	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60783054delA	uc001nqq.2	+						CD6_uc001nqp.2_Intron|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_Intron|CD6_uc001nqt.2_Intron	NM_006725	NP_006716			CD6 molecule precursor						cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1																		---	---	---	---
VPS37C	55048	broad.mit.edu	37	11	60906143	60906143	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60906143delA	uc001nqv.1	-						VPS37C_uc001nqw.1_Intron	NM_017966	NP_060436			vacuolar protein sorting 37C						cellular membrane organization|endosome transport|protein transport	late endosome membrane					0																		---	---	---	---
CPSF7	79869	broad.mit.edu	37	11	61183087	61183087	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61183087delA	uc001nrq.2	-						CPSF7_uc001nro.2_Intron|CPSF7_uc001nrp.2_Intron|CPSF7_uc001nrr.2_Intron	NM_001136040	NP_001129512			pre-mRNA cleavage factor I, 59 kDa subunit						mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1																		---	---	---	---
RAB3IL1	5866	broad.mit.edu	37	11	61669958	61669958	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:61669958delC	uc001nso.2	-	8	1113	c.955delG	c.(955-957)GACfs	p.D319fs	RAB3IL1_uc001nsp.2_Frame_Shift_Del_p.D293fs	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	319							protein binding			skin(2)|central_nervous_system(1)	3																		---	---	---	---
B3GAT3	26229	broad.mit.edu	37	11	62388038	62388038	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62388038delG	uc001ntw.2	-	2	217	c.188delC	c.(187-189)CCTfs	p.P63fs	B3GAT3_uc009ynz.2_Frame_Shift_Del_p.P56fs|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Frame_Shift_Del_p.P63fs	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	63	Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0																		---	---	---	---
GANAB	23193	broad.mit.edu	37	11	62398718	62398718	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62398718delA	uc001nub.2	-						GANAB_uc001nua.2_Intron|GANAB_uc001nuc.2_Intron|GANAB_uc010rma.1_Intron|GANAB_uc010rmb.1_Intron	NM_198334	NP_938148			neutral alpha-glucosidase AB isoform 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
INTS5	80789	broad.mit.edu	37	11	62414351	62414351	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62414351delA	uc001nud.2	-	2					GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131			integrator complex subunit 5						snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2																		---	---	---	---
MARK2	2011	broad.mit.edu	37	11	63670265	63670265	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63670265delC	uc001nxw.2	+						MARK2_uc001nxx.2_Intron|MARK2_uc001nxy.2_Intron|MARK2_uc001nxv.3_Intron|MARK2_uc001nxz.3_Intron|MARK2_uc009yoy.2_Intron	NM_001039469	NP_001034558			MAP/microtubule affinity-regulating kinase 2						cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3																		---	---	---	---
STIP1	10963	broad.mit.edu	37	11	63967532	63967532	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:63967532delG	uc001nyk.1	+						STIP1_uc010rnb.1_Intron	NM_006819	NP_006810			stress-induced-phosphoprotein 1						axon guidance|response to stress	Golgi apparatus|nucleus				ovary(2)|liver(1)	3																		---	---	---	---
RPS6KA4	8986	broad.mit.edu	37	11	64129306	64129306	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64129306delC	uc001oae.2	+						RPS6KA4_uc001oad.2_Intron|RPS6KA4_uc010rnl.1_Intron|RPS6KA4_uc001oaf.2_Intron|RPS6KA4_uc009ypp.2_Intron	NM_003942	NP_003933			ribosomal protein S6 kinase, 90kDa, polypeptide						axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5																		---	---	---	---
SLC25A45	283130	broad.mit.edu	37	11	65146837	65146838	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65146837_65146838insC	uc001odp.1	-						SLC25A45_uc009yqi.1_Intron|SLC25A45_uc001odq.1_Intron|SLC25A45_uc001odr.1_Intron|SLC25A45_uc001ods.1_Intron|SLC25A45_uc001odt.1_Intron	NM_001077241	NP_001070709			solute carrier family 25, member 45 isoform b						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
RELA	5970	broad.mit.edu	37	11	65422046	65422046	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65422046delG	uc001ofg.2	-	11	1599	c.1459delC	c.(1459-1461)CACfs	p.H487fs	RELA_uc001ofh.2_Frame_Shift_Del_p.H484fs|RELA_uc010ron.1_Frame_Shift_Del_p.H498fs|RELA_uc009yqr.2_Frame_Shift_Del_p.H434fs|RELA_uc001ofe.2_3'UTR|RELA_uc001off.2_Intron	NM_021975	NP_068810	Q04206	TF65_HUMAN	v-rel reticuloendotheliosis viral oncogene	487					anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			lung(3)|ovary(1)	4																		---	---	---	---
SF3B2	10992	broad.mit.edu	37	11	65836235	65836235	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65836235delT	uc001ogy.1	+	22					PACS1_uc001ogz.1_5'Flank|PACS1_uc001oha.1_5'Flank	NM_006842	NP_006833			splicing factor 3B subunit 2						interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3																OREG0021094	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KLC2	64837	broad.mit.edu	37	11	66032597	66032597	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66032597delG	uc010rov.1	+						KLC2_uc010row.1_Intron|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Intron|KLC2_uc010rox.1_Intron|KLC2_uc001ohc.2_Intron|KLC2_uc001ohd.2_Intron|KLC2_uc001ohe.1_Intron	NM_001134775	NP_001128247			kinesin light chain 2 isoform 1						blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0																OREG0021098	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NPAS4	266743	broad.mit.edu	37	11	66193601	66193601	+	3'UTR	DEL	G	-	-	rs66808652		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66193601delG	uc001ohx.1	+	8					NPAS4_uc010rpc.1_3'UTR	NM_178864	NP_849195			neuronal PAS domain protein 4						transcription, DNA-dependent		DNA binding|signal transducer activity				0																		---	---	---	---
MRPL11	65003	broad.mit.edu	37	11	66204985	66204985	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66204985delC	uc001ohz.3	-						MRPL11_uc001ohy.3_Intron|MRPL11_uc001oia.3_Intron	NM_016050	NP_057134			mitochondrial ribosomal protein L11 isoform a						translation		structural constituent of ribosome				0																		---	---	---	---
RBM14	10432	broad.mit.edu	37	11	66393160	66393160	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66393160delC	uc001oit.2	+						RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319			RNA binding motif protein 14						DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
KDM2A	22992	broad.mit.edu	37	11	66949250	66949250	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66949250delA	uc001ojw.2	+						KDM2A_uc001ojx.2_Intron	NM_012308	NP_036440			F-box and leucine-rich repeat protein 11						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
CHKA	1119	broad.mit.edu	37	11	67831875	67831875	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67831875delA	uc001onj.2	-						CHKA_uc001onk.2_Intron	NM_001277	NP_001268			choline kinase alpha isoform a						lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			ovary(1)|central_nervous_system(1)	2					Choline(DB00122)													---	---	---	---
SAPS3	55291	broad.mit.edu	37	11	68338585	68338585	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68338585delT	uc001onw.2	+						SAPS3_uc001onv.2_Intron|SAPS3_uc001ony.3_Intron|SAPS3_uc001onx.2_Intron|SAPS3_uc009ysh.2_Intron|SAPS3_uc001onu.2_Intron|SAPS3_uc010rqc.1_Intron|SAPS3_uc010rqd.1_Intron	NM_001164161	NP_001157633			SAPS domain family, member 3 isoform 6						regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)															---	---	---	---
ARAP1	116985	broad.mit.edu	37	11	72421120	72421120	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:72421120delG	uc001osu.2	-						ARAP1_uc001osv.2_Intron|ARAP1_uc001osr.2_Intron|ARAP1_uc001oss.2_Intron|ARAP1_uc009yth.2_Intron|ARAP1_uc010rre.1_Intron	NM_001040118	NP_001035207			ArfGAP with RhoGAP domain, ankyrin repeat and PH						actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1																		---	---	---	---
PGM2L1	283209	broad.mit.edu	37	11	74054211	74054211	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:74054211delT	uc001ovb.1	-							NM_173582	NP_775853			phosphoglucomutase 2-like 1						glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			ovary(1)	1	Breast(11;3.32e-06)																	---	---	---	---
C11orf30	56946	broad.mit.edu	37	11	76157923	76157923	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76157923delT	uc001oxl.2	+						C11orf30_uc001oxj.2_Intron|C11orf30_uc001oxk.2_Intron|C11orf30_uc009yuj.1_Intron|C11orf30_uc010rsa.1_Intron|C11orf30_uc001oxm.2_Intron|C11orf30_uc010rsb.1_5'Flank|C11orf30_uc010rsc.1_5'Flank|C11orf30_uc001oxn.2_5'Flank|C11orf30_uc010rsd.1_5'Flank	NM_020193	NP_064578			EMSY protein						chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6																		---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77639340	77639340	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77639340delG	uc001oys.2	-						INTS4_uc001oyt.2_Intron|INTS4_uc001oyu.1_Intron	NM_033547	NP_291025			integrator complex subunit 4						snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
CCDC83	220047	broad.mit.edu	37	11	85622574	85622574	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:85622574delA	uc001pbh.1	+						CCDC83_uc001pbg.1_Intron|CCDC83_uc001pbi.1_Intron|CCDC83_uc001pbj.1_Intron	NM_173556	NP_775827			coiled-coil domain containing 83											skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)																---	---	---	---
C11orf73	51501	broad.mit.edu	37	11	86055838	86055838	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86055838delT	uc001pbu.2	+						C11orf73_uc001pbt.2_3'UTR|C11orf73_uc010rto.1_Intron|C11orf73_uc010rtp.1_Intron|C11orf73_uc001pbv.2_Intron	NM_016401	NP_057485			lethal, Chr 7, Rinchik 6							cytoplasm					0		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)																---	---	---	---
NOX4	50507	broad.mit.edu	37	11	89173894	89173895	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89173894_89173895insA	uc001pct.2	-						NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_Intron|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Intron|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Intron|NOX4_uc009yvq.2_Intron|NOX4_uc009yvs.1_Intron	NM_016931	NP_058627			NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)																---	---	---	---
FOLH1B	219595	broad.mit.edu	37	11	89420491	89420492	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89420491_89420492insT	uc001pda.2	+							NM_153696	NP_710163			folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6																		---	---	---	---
TRIM49	57093	broad.mit.edu	37	11	89534160	89534161	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89534160_89534161delAA	uc001pdb.2	-							NM_020358	NP_065091			ring finger protein 18							intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
TRIM49	57093	broad.mit.edu	37	11	89536750	89536751	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89536750_89536751delTT	uc001pdb.2	-							NM_020358	NP_065091			ring finger protein 18							intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
NAALAD2	10003	broad.mit.edu	37	11	89868965	89868965	+	Intron	DEL	T	-	-	rs34639551		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:89868965delT	uc001pdf.3	+						NAALAD2_uc009yvx.2_Intron|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pdd.2_Intron|NAALAD2_uc001pde.2_Intron	NM_005467	NP_005458			N-acetylated alpha-linked acidic dipeptidase 2						proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92430651	92430652	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92430651_92430652delTT	uc001pdj.3	+							NM_001008781	NP_001008781			FAT tumor suppressor homolog 3						homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92600371	92600371	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92600371delG	uc001pdj.3	+	21	12140	c.12123delG	c.(12121-12123)TCGfs	p.S4041fs	FAT3_uc001pdi.3_Frame_Shift_Del_p.S481fs	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4041	EGF-like 2.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
TAF1D	79101	broad.mit.edu	37	11	93465462	93465462	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93465462delA	uc001pdz.2	-						SNORA8_uc001pec.2_RNA|SNORA25_uc001pdy.3_5'Flank|SNORA32_uc009ywc.1_5'Flank|TAF1D_uc001pea.1_RNA|SNORD6_uc001peb.2_5'Flank|SNORA1_uc009ywd.1_5'Flank	NM_024116				TATA box binding protein (TBP)-associated						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding				0																		---	---	---	---
CWC15	51503	broad.mit.edu	37	11	94696475	94696475	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94696475delA	uc001pfd.3	-	8						NM_016403	NP_057487			CWC15 homolog						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome	protein binding|RNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
CEP57	9702	broad.mit.edu	37	11	95551111	95551111	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95551111delT	uc001pfp.1	+						CEP57_uc001pfo.1_Intron|CEP57_uc010ruh.1_Intron|CEP57_uc010rui.1_Intron|CEP57_uc009ywn.1_Intron|CEP57_uc001pfq.1_Intron|CEP57_uc001pfr.1_Intron	NM_014679	NP_055494			translokin						fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)												Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
CEP57	9702	broad.mit.edu	37	11	95561203	95561203	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95561203delT	uc001pfp.1	+						CEP57_uc010ruh.1_Intron|CEP57_uc010rui.1_Intron|CEP57_uc009ywn.1_Intron|CEP57_uc001pfq.1_Intron|CEP57_uc001pfr.1_Intron	NM_014679	NP_055494			translokin						fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)												Mosaic_Variegated_Aneuploidy_Syndrome				---	---	---	---
Unknown	0	broad.mit.edu	37	11	97158168	97158168	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:97158168delT								None (None upstream) : None (None downstream)																																			---	---	---	---
CNTN5	53942	broad.mit.edu	37	11	99942594	99942594	+	Intron	DEL	A	-	-	rs76748292		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:99942594delA	uc001pga.2	+						CNTN5_uc009ywv.1_Intron|CNTN5_uc001pfz.2_Intron|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176			contactin 5 isoform long						cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)														---	---	---	---
KIAA1377	57562	broad.mit.edu	37	11	101832459	101832459	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:101832459delT	uc001pgm.2	+						KIAA1377_uc001pgn.2_Intron|KIAA1377_uc010run.1_Intron|KIAA1377_uc009yxa.1_Intron	NM_020802	NP_065853			hypothetical protein LOC57562								protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103123994	103123995	+	Intron	DEL	TG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103123994_103123995delTG	uc001pho.2	+						DYNC2H1_uc001phn.1_Intron|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932			dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
DYNC2H1	79659	broad.mit.edu	37	11	103194726	103194726	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:103194726delA	uc001pho.2	+						DYNC2H1_uc001phn.1_Intron|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932			dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)														---	---	---	---
AASDHPPT	60496	broad.mit.edu	37	11	105961907	105961907	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:105961907delT	uc001pjc.1	+						AASDHPPT_uc010rvn.1_Intron|AASDHPPT_uc001pjd.1_Intron	NM_015423	NP_056238			aminoadipate-semialdehyde						macromolecule biosynthetic process|pantothenate metabolic process	cytosol	holo-[acyl-carrier-protein] synthase activity|magnesium ion binding|protein binding				0		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.78e-05)|Epithelial(105;0.00622)|all cancers(92;0.041)														---	---	---	---
ALKBH8	91801	broad.mit.edu	37	11	107427812	107427813	+	Intron	INS	-	A	A	rs112523545	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107427812_107427813insA	uc010rvr.1	-						ALKBH8_uc010rvq.1_5'Flank|ALKBH8_uc009yxp.2_Intron|ALKBH8_uc001pjl.2_Intron	NM_138775	NP_620130			alkB, alkylation repair homolog 8						response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)														---	---	---	---
ATM	472	broad.mit.edu	37	11	108206006	108206006	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108206006delT	uc001pkb.1	+						ATM_uc009yxr.1_Intron|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_RNA|ATM_uc001pke.1_Intron	NM_000051	NP_000042			ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)				D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			---	---	---	---
C11orf65	160140	broad.mit.edu	37	11	108263819	108263819	+	Intron	DEL	T	-	-	rs7948591	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108263819delT	uc001pkh.2	-						C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron	NM_152587	NP_689800			hypothetical protein LOC160140											ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)														---	---	---	---
RDX	5962	broad.mit.edu	37	11	110118357	110118357	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110118357delA	uc001pku.2	-						RDX_uc009yxx.1_Intron|RDX_uc009yxy.2_Intron|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Intron|RDX_uc010rwe.1_Intron	NM_002906	NP_002897			radixin						actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	110976597	110976598	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110976597_110976598insT								ARHGAP20 (392685 upstream) : C11orf53 (150109 downstream)																																			---	---	---	---
LAYN	143903	broad.mit.edu	37	11	111428186	111428186	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111428186delT	uc001plr.1	+						LAYN_uc001plp.1_Intron|LAYN_uc001plq.1_Intron|LAYN_uc001pls.1_Intron|LAYN_uc010rwg.1_Intron|LAYN_uc010rwh.1_Intron	NM_178834	NP_849156			layilin							cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)														---	---	---	---
IL18	3606	broad.mit.edu	37	11	112020784	112020784	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112020784delA	uc001pnb.1	-						IL18_uc001pna.1_Intron|IL18_uc009yym.1_Intron	NM_001562	NP_001553			interleukin 18 proprotein						angiogenesis|cell-cell signaling|chemokine biosynthetic process|granulocyte macrophage colony-stimulating factor biosynthetic process|interferon-gamma biosynthetic process|interleukin-13 biosynthetic process|interleukin-2 biosynthetic process|positive regulation of activated T cell proliferation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of NK T cell proliferation|regulation of cell adhesion|sleep|T-helper 1 type immune response|type 2 immune response	cytosol|extracellular space	cytokine activity|signal transducer activity				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|Epithelial(105;8.15e-07)|all cancers(92;1.43e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.055)														---	---	---	---
PTS	5805	broad.mit.edu	37	11	112100900	112100901	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:112100900_112100901insT	uc001pnj.3	+						PTS_uc009yyo.2_Intron	NM_000317	NP_000308			6-pyruvoyltetrahydropterin synthase						cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)														---	---	---	---
ZW10	9183	broad.mit.edu	37	11	113608928	113608928	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113608928delA	uc001poe.2	-						ZW10_uc009yyv.2_Intron	NM_004724	NP_004715			centromere/kinetochore protein zw10						cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)														---	---	---	---
USP28	57646	broad.mit.edu	37	11	113673924	113673924	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:113673924delC	uc001poh.2	-	23	2851	c.2818delG	c.(2818-2820)GTCfs	p.V940fs	USP28_uc001pog.2_Frame_Shift_Del_p.V616fs|USP28_uc010rwy.1_Frame_Shift_Del_p.V783fs|USP28_uc001poi.2_Frame_Shift_Del_p.V263fs	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	940					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)														---	---	---	---
SIK3	23387	broad.mit.edu	37	11	116906447	116906447	+	Intron	DEL	T	-	-	rs113834558		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:116906447delT	uc001ppy.2	-						SIK3_uc001ppz.2_Intron|SIK3_uc001pqa.2_Intron	NM_025164	NP_079440			serine/threonine-protein kinase QSK							cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12																		---	---	---	---
UBE4A	9354	broad.mit.edu	37	11	118243701	118243703	+	Intron	DEL	AAA	-	-	rs34104337		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118243701_118243703delAAA	uc001psw.2	+						UBE4A_uc001psv.2_Intron	NM_004788	NP_004779			ubiquitination factor E4A						ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	5	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)														---	---	---	---
MLL	4297	broad.mit.edu	37	11	118309704	118309704	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118309704delT	uc001pta.2	+						MLL_uc001ptb.2_Intron|MLL_uc001psz.1_Intron	NM_005933	NP_005924			myeloid/lymphoid or mixed-lineage leukemia						apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
DDX6	1656	broad.mit.edu	37	11	118626216	118626216	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118626216delA	uc001pub.2	-						DDX6_uc001pua.2_Intron|DDX6_uc001puc.2_Intron	NM_004397	NP_004388			DEAD (Asp-Glu-Ala-Asp) box polypeptide 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			ovary(1)	1	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)				T	IGH@	B-NHL								---	---	---	---
FOXR1	283150	broad.mit.edu	37	11	118850076	118850077	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118850076_118850077insC	uc001pui.2	+						FOXR1_uc001puj.2_Intron|FOXR1_uc001puk.2_Intron	NM_181721	NP_859072			forkhead box R1						embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)														---	---	---	---
CBL	867	broad.mit.edu	37	11	119145387	119145389	+	Intron	DEL	CTC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119145387_119145389delCTC	uc001pwe.2	+							NM_005188	NP_005179			Cas-Br-M (murine) ecotropic retroviral						epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)										CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				---	---	---	---
ARHGEF12	23365	broad.mit.edu	37	11	120318562	120318562	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120318562delT	uc001pxl.1	+						ARHGEF12_uc009zat.2_Intron|ARHGEF12_uc010rzn.1_Intron|ARHGEF12_uc009zau.1_Intron	NM_015313	NP_056128			Rho guanine nucleotide exchange factor (GEF) 12						apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)				T	MLL	AML								---	---	---	---
ARHGEF12	23365	broad.mit.edu	37	11	120336183	120336183	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120336183delT	uc001pxl.1	+						ARHGEF12_uc009zat.2_Intron|ARHGEF12_uc010rzn.1_Intron|ARHGEF12_uc009zau.1_Intron	NM_015313	NP_056128			Rho guanine nucleotide exchange factor (GEF) 12						apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)				T	MLL	AML								---	---	---	---
UBASH3B	84959	broad.mit.edu	37	11	122650537	122650538	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:122650537_122650538insA	uc001pyi.3	+							NM_032873	NP_116262			ubiquitin associated and SH3 domain containing,							cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)														---	---	---	---
ROBO3	64221	broad.mit.edu	37	11	124749476	124749476	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:124749476delG	uc001qbc.2	+						ROBO3_uc001qbd.2_Intron|ROBO3_uc010sar.1_Intron|ROBO3_uc001qbe.2_Intron|ROBO3_uc001qbf.1_Intron	NM_022370	NP_071765			roundabout, axon guidance receptor, homolog 3						axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)														---	---	---	---
STT3A	3703	broad.mit.edu	37	11	125481184	125481185	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:125481184_125481185delTT	uc001qcd.2	+						STT3A_uc001qce.2_Intron|STT3A_uc010sbg.1_Intron|STT3A_uc009zbn.2_Intron	NM_152713	NP_689926			integral membrane protein 1						post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134072805	134072805	+	Intron	DEL	A	-	-	rs34989286		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134072805delA	uc001qhd.1	-						NCAPD3_uc010scm.1_Intron|NCAPD3_uc009zda.1_Intron	NM_015261	NP_056076			non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
NCAPD3	23310	broad.mit.edu	37	11	134078848	134078848	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134078848delA	uc001qhd.1	-						NCAPD3_uc010scm.1_Intron|NCAPD3_uc009zda.1_Intron	NM_015261	NP_056076			non-SMC condensin II complex, subunit D3						cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)														---	---	---	---
THYN1	29087	broad.mit.edu	37	11	134119613	134119613	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134119613delG	uc001qhf.2	-						THYN1_uc001qhg.2_Intron|THYN1_uc001qhh.2_Intron|THYN1_uc001qhi.2_Intron|THYN1_uc001qhj.2_Intron|THYN1_uc009zdb.2_Intron	NM_001037305	NP_001032382			thymocyte nuclear protein 1 isoform 1							nucleus					0	all_hematologic(175;0.127)	all_cancers(12;1.1e-21)|all_epithelial(12;3.77e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;1.68e-10)|all cancers(11;1.95e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00148)|Lung(977;0.207)														---	---	---	---
LOC100288778	100288778	broad.mit.edu	37	12	90625	90626	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:90625_90626insT	uc010scy.1	+	9	1186_1187	c.631_632insT	c.(631-633)CTCfs	p.L211fs	LOC100288778_uc010scz.1_RNA|LOC100288778_uc010sdd.1_Frame_Shift_Ins_p.S209fs|LOC100288778_uc010sde.1_Frame_Shift_Ins_p.L211fs|LOC100288778_uc010sdf.1_Frame_Shift_Ins_p.L211fs|LOC100288778_uc010sdg.1_Frame_Shift_Ins_p.L211fs|LOC100288778_uc010sdh.1_RNA					SubName: Full=Actin nucleation promoting factor; Flags: Fragment;												0																		---	---	---	---
IQSEC3	440073	broad.mit.edu	37	12	278003	278003	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:278003delG	uc001qhw.1	+						IQSEC3_uc001qhu.1_Intron	NM_015232	NP_056047			IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)														---	---	---	---
KDM5A	5927	broad.mit.edu	37	12	416953	416953	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:416953delT	uc001qif.1	-	23	3960	c.3597delA	c.(3595-3597)AAAfs	p.K1199fs	KDM5A_uc001qie.1_Frame_Shift_Del_p.K1199fs	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1199	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3								T 	NUP98	AML								---	---	---	---
KDM5A	5927	broad.mit.edu	37	12	442585	442585	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:442585delA	uc001qif.1	-						KDM5A_uc001qie.1_Intron|KDM5A_uc010sdn.1_Intron|KDM5A_uc010sdo.1_Intron	NM_001042603	NP_001036068			retinoblastoma binding protein 2 isoform 1						chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3								T 	NUP98	AML								---	---	---	---
B4GALNT3	283358	broad.mit.edu	37	12	645501	645501	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:645501delA	uc001qii.1	+							NM_173593	NP_775864			beta							Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)															---	---	---	---
PRMT8	56341	broad.mit.edu	37	12	3649793	3649793	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:3649793delC	uc001qmf.2	+	2	464	c.97delC	c.(97-99)CCCfs	p.P33fs	PRMT8_uc009zed.2_Frame_Shift_Del_p.P24fs|PRMT8_uc009zee.1_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	33	SH3-binding 1.				regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)															---	---	---	---
C12orf4	57102	broad.mit.edu	37	12	4609207	4609207	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4609207delA	uc001qms.2	-						C12orf4_uc001qmt.2_Intron	NM_020374	NP_065107			hypothetical protein LOC57102												0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)														---	---	---	---
NTF3	4908	broad.mit.edu	37	12	5603308	5603309	+	5'UTR	DEL	AC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:5603308_5603309delAC	uc001qnl.3	+	1					NTF3_uc001qnk.3_Intron	NM_002527	NP_002518			neurotrophin 3 isoform 2 preproprotein						signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1																		---	---	---	---
VWF	7450	broad.mit.edu	37	12	6058813	6058813	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6058813delA	uc001qnn.1	-						VWF_uc010set.1_Intron	NM_000552	NP_000543			von Willebrand factor preproprotein						blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)													---	---	---	---
VWF	7450	broad.mit.edu	37	12	6103387	6103388	+	Intron	INS	-	A	A	rs71579346		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6103387_6103388insA	uc001qnn.1	-						VWF_uc010set.1_Intron	NM_000552	NP_000543			von Willebrand factor preproprotein						blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)													---	---	---	---
EMG1	10436	broad.mit.edu	37	12	7084957	7084958	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7084957_7084958insG	uc001qsh.3	+	8	864_865	c.721_722insG	c.(721-723)TGGfs	p.W241fs	EMG1_uc009zfo.2_RNA|EMG1_uc010sfv.1_Intron	NM_006331	NP_006322	Q92979	NEP1_HUMAN	ribosome biogenesis protein NEP1	241					ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding				0																		---	---	---	---
C1RL	51279	broad.mit.edu	37	12	7254693	7254695	+	Intron	DEL	GGA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7254693_7254695delGGA	uc001qsn.2	-						C1RL_uc009zft.2_Intron|C1RL_uc001qso.1_Intron	NM_016546	NP_057630			complement component 1, r subcomponent-like						complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1																		---	---	---	---
CD163L1	283316	broad.mit.edu	37	12	7556021	7556021	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7556021delT	uc001qsy.2	-						CD163L1_uc010sge.1_Intron	NM_174941	NP_777601			scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11																		---	---	---	---
SLC2A14	144195	broad.mit.edu	37	12	7981152	7981153	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7981152_7981153insA	uc001qtk.2	-						SLC2A14_uc001qtl.2_Intron|SLC2A14_uc001qtm.2_Intron|SLC2A14_uc010sgg.1_Intron|SLC2A14_uc001qtn.2_Intron|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Intron	NM_153449	NP_703150			glucose transporter 14						cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)														---	---	---	---
Unknown	0	broad.mit.edu	37	12	8048030	8048030	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8048030delA	uc001qtp.1	+											RecName: Full=Putative homeobox protein NANOG2;																														---	---	---	---
RIMKLB	57494	broad.mit.edu	37	12	8906367	8906367	+	Intron	DEL	A	-	-	rs146605560		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:8906367delA	uc001quu.2	+						RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Intron|RIMKLB_uc010sgl.1_Intron|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785			ribosomal modification protein rimK-like family						protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0																		---	---	---	---
A2ML1	144568	broad.mit.edu	37	12	9021706	9021706	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9021706delT	uc001quz.3	+						A2ML1_uc001qva.1_Intron|A2ML1_uc010sgm.1_Intron|A2ML1_uc001qvb.1_Intron	NM_144670	NP_653271			alpha-2-macroglobulin-like 1 precursor							extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
PZP	5858	broad.mit.edu	37	12	9313518	9313518	+	Intron	DEL	T	-	-	rs7972015	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9313518delT	uc001qvl.2	-						PZP_uc009zgl.2_Intron|PZP_uc010sgo.1_Intron	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	9659344	9659344	+	IGR	DEL	T	-	-	rs66775564		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9659344delT								DDX12 (58576 upstream) : KLRB1 (88527 downstream)																																			---	---	---	---
TAS2R10	50839	broad.mit.edu	37	12	10978282	10978282	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10978282delA	uc001qyy.1	-	1	587	c.587delT	c.(586-588)TTAfs	p.L196fs		NM_023921	NP_076410	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	196	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	taste receptor activity				0																		---	---	---	---
ATF7IP	55729	broad.mit.edu	37	12	14628944	14628944	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14628944delT	uc001rbw.2	+						ATF7IP_uc001rbu.2_Frame_Shift_Del_p.F995fs|ATF7IP_uc001rbv.1_Intron|ATF7IP_uc001rbx.2_Intron|ATF7IP_uc001rby.3_Intron|ATF7IP_uc001rca.2_Intron	NM_018179	NP_060649			activating transcription factor 7 interacting						DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5																		---	---	---	---
ART4	420	broad.mit.edu	37	12	14982272	14982272	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:14982272delT	uc001rcl.1	-	3					ART4_uc009zid.1_RNA|ART4_uc009zie.1_RNA	NM_021071	NP_066549			ADP-ribosyltransferase 4 precursor						arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	12	16555113	16555113	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:16555113delT								MGST1 (31771 upstream) : LMO3 (146194 downstream)																																			---	---	---	---
RERGL	79785	broad.mit.edu	37	12	18234035	18234035	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:18234035delA	uc001rdq.2	-	6					RERGL_uc001rdr.2_3'UTR	NM_024730	NP_079006			RERG/RAS-like						signal transduction	membrane	GTP binding|GTPase activity				0																		---	---	---	---
PLEKHA5	54477	broad.mit.edu	37	12	19422638	19422638	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:19422638delT	uc001reb.2	+						PLEKHA5_uc010sie.1_Intron|PLEKHA5_uc001rea.2_Intron|PLEKHA5_uc009zin.2_Intron|PLEKHA5_uc010sif.1_Intron|PLEKHA5_uc010sig.1_Intron|PLEKHA5_uc010sih.1_Intron	NM_019012	NP_061885			pleckstrin homology domain containing, family A								1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)																	---	---	---	---
Unknown	0	broad.mit.edu	37	12	20096042	20096042	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:20096042delA								AEBP2 (420869 upstream) : PDE3A (426155 downstream)																																			---	---	---	---
PYROXD1	79912	broad.mit.edu	37	12	21620663	21620663	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21620663delA	uc001rew.2	+						PYROXD1_uc009ziq.2_Intron|PYROXD1_uc009zir.2_Intron	NM_024854	NP_079130			pyridine nucleotide-disulphide oxidoreductase								oxidoreductase activity			ovary(1)	1																		---	---	---	---
ABCC9	10060	broad.mit.edu	37	12	22025423	22025423	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:22025423delT	uc001rfi.1	-						ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Intron	NM_005691	NP_005682			ATP-binding cassette, sub-family C, member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)													---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26596618	26596618	+	Intron	DEL	C	-	-	rs2220406	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26596618delC	uc001rhg.2	-						ITPR2_uc009zjg.1_Intron	NM_002223	NP_002214			inositol 1,4,5-triphosphate receptor, type 2						activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27800899	27800899	+	Intron	DEL	A	-	-	rs112008008		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27800899delA	uc001ric.1	+						PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Intron|PPFIBP1_uc001ria.2_Intron|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613			PTPRF interacting protein binding protein 1						cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
KLHDC5	57542	broad.mit.edu	37	12	27950769	27950769	+	Frame_Shift_Del	DEL	G	-	-	rs145908611	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27950769delG	uc001rij.2	+	3	1265	c.1188delG	c.(1186-1188)GTGfs	p.V396fs	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	396	Kelch 5.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)																	---	---	---	---
IPO8	10526	broad.mit.edu	37	12	30783922	30783922	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:30783922delA	uc001rjd.2	-						IPO8_uc001rje.1_3'UTR|IPO8_uc010sjt.1_Intron	NM_006390	NP_006381			importin 8						intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)																	---	---	---	---
FAM60A	58516	broad.mit.edu	37	12	31448178	31448178	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31448178delT	uc010sjz.1	-	3	457	c.218delA	c.(217-219)AACfs	p.N73fs	FAM60A_uc001rkd.2_Frame_Shift_Del_p.N73fs|FAM60A_uc010ska.1_Frame_Shift_Del_p.N73fs|FAM60A_uc001rke.2_Frame_Shift_Del_p.N73fs|FAM60A_uc010skb.1_Intron|FAM60A_uc001rkc.2_Frame_Shift_Del_p.N98fs	NM_021238	NP_067061	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	73											0	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)																	---	---	---	---
DENND5B	160518	broad.mit.edu	37	12	31577379	31577380	+	Intron	DEL	TT	-	-	rs68117503		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:31577379_31577380delTT	uc001rki.1	-						DENND5B_uc001rkh.1_Intron|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410			DENN/MADD domain containing 5B							integral to membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
C12orf35	55196	broad.mit.edu	37	12	32140362	32140363	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32140362_32140363delTT	uc001rks.2	+						C12orf35_uc001rkt.2_Intron	NM_018169	NP_060639			hypothetical protein LOC55196											ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)															---	---	---	---
FGD4	121512	broad.mit.edu	37	12	32761038	32761038	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32761038delT	uc001rkz.2	+						FGD4_uc001rlc.2_Intron|FGD4_uc001rky.2_Intron|FGD4_uc001rla.2_Intron|FGD4_uc010ske.1_Intron|FGD4_uc001rlb.1_Intron	NM_139241	NP_640334			FYVE, RhoGEF and PH domain containing 4						actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)																	---	---	---	---
DNM1L	10059	broad.mit.edu	37	12	32890767	32890767	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:32890767delT	uc001rld.2	+						DNM1L_uc001rle.2_Intron|DNM1L_uc001rlf.2_Intron|DNM1L_uc010skh.1_Intron|DNM1L_uc001rlg.2_Intron|DNM1L_uc001rlh.2_Intron|DNM1L_uc010ski.1_Intron	NM_012062	NP_036192			dynamin 1-like isoform 1						cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)																	---	---	---	---
CPNE8	144402	broad.mit.edu	37	12	39223056	39223057	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39223056_39223057insA	uc001rls.1	-							NM_153634	NP_705898			copine VIII											pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)																---	---	---	---
KIF21A	55605	broad.mit.edu	37	12	39713784	39713784	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:39713784delT	uc001rly.2	-	28	3849	c.3703delA	c.(3703-3705)ATTfs	p.I1235fs	KIF21A_uc001rlv.2_Frame_Shift_Del_p.I240fs|KIF21A_uc001rlw.2_Frame_Shift_Del_p.I552fs|KIF21A_uc001rlx.2_Frame_Shift_Del_p.I1222fs|KIF21A_uc001rlz.2_Frame_Shift_Del_p.I1199fs|KIF21A_uc010skl.1_Frame_Shift_Del_p.I1215fs|KIF21A_uc001rlu.2_5'UTR	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1235					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)																---	---	---	---
C12orf40	283461	broad.mit.edu	37	12	40020151	40020151	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40020151delG	uc001rmc.2	+	1	180	c.13delG	c.(13-15)GGGfs	p.G5fs	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	5										ovary(6)	6																		---	---	---	---
SLC2A13	114134	broad.mit.edu	37	12	40247410	40247410	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:40247410delT	uc010skm.1	-						C12orf40_uc009zjv.1_Intron|SLC2A13_uc001rme.1_Intron	NM_052885	NP_443117			solute carrier family 2 (facilitated glucose							integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)													HNSCC(50;0.14)			---	---	---	---
ARID2	196528	broad.mit.edu	37	12	46124006	46124006	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46124006delG	uc001ros.1	+						ARID2_uc001ror.2_Intron|LOC400027_uc001roq.2_5'Flank	NM_152641	NP_689854			AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)														---	---	---	---
ARID2	196528	broad.mit.edu	37	12	46275603	46275603	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46275603delT	uc001ros.1	+						ARID2_uc001ror.2_Intron|ARID2_uc009zkg.1_Intron|ARID2_uc009zkh.1_Intron|ARID2_uc001rou.1_Intron	NM_152641	NP_689854			AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)														---	---	---	---
ARID2	196528	broad.mit.edu	37	12	46287171	46287172	+	Intron	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46287171_46287172delTC	uc001ros.1	+						ARID2_uc001ror.2_Intron|ARID2_uc009zkg.1_Intron|ARID2_uc009zkh.1_Intron|ARID2_uc001rou.1_Intron	NM_152641	NP_689854			AT rich interactive domain 2 (ARID, RFX-like)						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)														---	---	---	---
SLC38A4	55089	broad.mit.edu	37	12	47170830	47170830	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47170830delA	uc001rpi.2	-						SLC38A4_uc001rpj.2_Intron	NM_018018	NP_060488			solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)																	---	---	---	---
SLC38A4	55089	broad.mit.edu	37	12	47173922	47173922	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:47173922delA	uc001rpi.2	-						SLC38A4_uc001rpj.2_Intron|SLC38A4_uc009zkl.2_Intron	NM_018018	NP_060488			solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Lung SC(27;0.192)|Renal(347;0.236)																	---	---	---	---
COL2A1	1280	broad.mit.edu	37	12	48391482	48391483	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48391482_48391483insG	uc001rqu.2	-	7	618_619	c.437_438insC	c.(436-438)CCTfs	p.P146fs	COL2A1_uc001rqv.2_Frame_Shift_Ins_p.P77fs	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	146					axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)													---	---	---	---
ADCY6	112	broad.mit.edu	37	12	49163028	49163028	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49163028delA	uc001rsh.3	-						ADCY6_uc001rsj.3_Intron|ADCY6_uc001rsi.3_Intron	NM_015270	NP_056085			adenylate cyclase 6 isoform a						activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0																		---	---	---	---
WNT1	7471	broad.mit.edu	37	12	49374348	49374348	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49374348delG	uc001rsu.2	+	3	698	c.500delG	c.(499-501)TGGfs	p.W167fs		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	167					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)														---	---	---	---
ATF1	466	broad.mit.edu	37	12	51174134	51174134	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:51174134delT	uc001rww.3	+						ATF1_uc010smu.1_Intron	NM_005171	NP_005162			activating transcription factor 1						innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329								T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								---	---	---	---
KRT1	3848	broad.mit.edu	37	12	53071611	53071611	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53071611delA	uc001sau.1	-						KRT1_uc001sav.1_Intron	NM_006121	NP_006112			keratin 1						complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2																		---	---	---	---
EIF4B	1975	broad.mit.edu	37	12	53400323	53400323	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53400323delC	uc001sbh.3	+						EIF4B_uc009zmp.1_Intron|EIF4B_uc010snu.1_Intron|EIF4B_uc010snv.1_Intron	NM_001417	NP_001408			eukaryotic translation initiation factor 4B						insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2																		---	---	---	---
CS	1431	broad.mit.edu	37	12	56677665	56677665	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56677665delA	uc001sks.1	-						CS_uc010sql.1_Intron|CS_uc001skr.1_Intron|CS_uc001skt.1_Intron|CS_uc010sqm.1_Intron	NM_004077	NP_004068			citrate synthase precursor						cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity				0		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)														---	---	---	---
NACA	4666	broad.mit.edu	37	12	57113958	57113960	+	Intron	DEL	TGC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57113958_57113960delTGC	uc001slz.2	-						NACA_uc001sly.2_Intron|NACA_uc009zoy.1_In_Frame_Del_p.A452del|NACA_uc001smc.2_Intron|NACA_uc001sma.2_In_Frame_Del_p.A452del|NACA_uc001smb.2_Intron|NACA_uc010squ.1_Intron	NM_001113201	NP_001106672			nascent polypeptide-associated complex alpha						interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1								T	BCL6	NHL								---	---	---	---
HSD17B6	8630	broad.mit.edu	37	12	57175586	57175586	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57175586delA	uc001smg.1	+							NM_003725	NP_003716			hydroxysteroid (17-beta) dehydrogenase 6						androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			upper_aerodigestive_tract(1)|pancreas(1)	2					Succinic acid(DB00139)													---	---	---	---
LRP1	4035	broad.mit.edu	37	12	57596947	57596947	+	Intron	DEL	C	-	-	rs75290992	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57596947delC	uc001snd.2	+							NM_002332	NP_002323			low density lipoprotein-related protein 1						aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)													---	---	---	---
MARS	4141	broad.mit.edu	37	12	57905367	57905367	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57905367delA	uc001sog.2	+						MARS_uc001sof.1_Intron|MARS_uc010srp.1_Intron|MARS_uc010srq.1_Intron|MARS_uc001soh.1_5'Flank	NM_004990	NP_004981			methionyl-tRNA synthetase						methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)													---	---	---	---
MBD6	114785	broad.mit.edu	37	12	57921002	57921002	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57921002delC	uc001soj.1	+	7	2298	c.2074delC	c.(2074-2076)CCCfs	p.P692fs	MBD6_uc001sok.1_Frame_Shift_Del_p.P559fs|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	692	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4																		---	---	---	---
TSPAN31	6302	broad.mit.edu	37	12	58141155	58141156	+	3'UTR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58141155_58141156insT	uc001spt.2	+	6					TSPAN31_uc009zqb.2_3'UTR|TSPAN31_uc010ssa.1_3'UTR	NM_005981	NP_005972			sarcoma amplified sequence						positive regulation of cell proliferation	integral to plasma membrane|membrane fraction					0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)															---	---	---	---
MON2	23041	broad.mit.edu	37	12	62919633	62919634	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:62919633_62919634insT	uc001sre.2	+						MON2_uc009zqj.2_Intron|MON2_uc010ssl.1_Intron|MON2_uc010ssm.1_Intron|MON2_uc010ssn.1_Intron|MON2_uc001srf.2_Intron	NM_015026	NP_055841			MON2 homolog						Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)														---	---	---	---
AVPR1A	552	broad.mit.edu	37	12	63541343	63541343	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:63541343delA	uc001sro.1	-	2	3027	c.1053delT	c.(1051-1053)TTTfs	p.F351fs		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	351	Helical; Name=7; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)													---	---	---	---
XPOT	11260	broad.mit.edu	37	12	64815400	64815401	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:64815400_64815401insA	uc001ssb.2	+							NM_007235	NP_009166			tRNA exportin						intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)														---	---	---	---
LEMD3	23592	broad.mit.edu	37	12	65604819	65604819	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:65604819delA	uc001ssl.1	+						LEMD3_uc009zqo.1_Intron	NM_014319	NP_055134			LEM domain containing 3						negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)														---	---	---	---
HMGA2	8091	broad.mit.edu	37	12	66221759	66221759	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:66221759delT	uc001ssx.2	+						RPSAP52_uc001sso.2_5'Flank|HMGA2_uc001ssw.1_Intron|HMGA2_uc001ssp.1_Intron|HMGA2_uc010ssv.1_Intron|HMGA2_uc001sss.1_Intron|HMGA2_uc001sst.1_Intron|HMGA2_uc001ssu.1_Intron|HMGA2_uc001ssv.2_Intron	NM_003483	NP_003474			high mobility group AT-hook 2 isoform a						cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/LPP(161)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/RAD51B(11)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/CCNB1IP1(2)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/COX6C(2)	soft_tissue(159)|bone(27)|salivary_gland(22)	208	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)				T	 LHFP|RAD51L1|LPP|HEI10|COX6C|CMKOR1|NFIB|ALDH2|CCNB1IP1|EBF1|WIF1|FHIT	lipoma|leiomyoma|pleiomorphic salivary gland adenoma								---	---	---	---
Unknown	0	broad.mit.edu	37	12	67745799	67745800	+	IGR	DEL	AC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:67745799_67745800delAC								CAND1 (37411 upstream) : DYRK2 (296712 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	12	69594093	69594102	+	IGR	DEL	AGAAAGAGAT	-	-	rs80081772		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69594093_69594102delAGAAAGAGAT								CPM (237073 upstream) : CPSF6 (39215 downstream)																																			---	---	---	---
CPSF6	11052	broad.mit.edu	37	12	69646940	69646940	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69646940delT	uc001sut.3	+						CPSF6_uc001suu.3_Intron	NM_007007	NP_008938			cleavage and polyadenylation specific factor 6,						mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)															---	---	---	---
CCT2	10576	broad.mit.edu	37	12	69992259	69992259	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:69992259delT	uc001svb.1	+						CCT2_uc009zrm.1_Intron|CCT2_uc009zrn.1_Intron|CCT2_uc010stl.1_Intron	NM_006431	NP_006422			chaperonin containing TCP1, subunit 2						'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)															---	---	---	---
CNOT2	4848	broad.mit.edu	37	12	70739865	70739865	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70739865delT	uc001svv.2	+						CNOT2_uc009zro.2_Intron|CNOT2_uc009zrp.2_Intron|CNOT2_uc009zrq.2_Intron	NM_014515	NP_055330			CCR4-NOT transcription complex, subunit 2						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)															---	---	---	---
ZFC3H1	196441	broad.mit.edu	37	12	72022858	72022858	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72022858delT	uc001swo.2	-							NM_144982	NP_659419			proline/serine-rich coiled-coil 2						RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
KCNC2	3747	broad.mit.edu	37	12	75435997	75435999	+	Intron	DEL	TTA	-	-	rs7969026	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:75435997_75435999delTTA	uc009zry.2	-						KCNC2_uc001sxe.2_Intron|KCNC2_uc001sxf.2_Intron	NM_139136	NP_631874			Shaw-related voltage-gated potassium channel						energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6																		---	---	---	---
NAP1L1	4673	broad.mit.edu	37	12	76442093	76442093	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:76442093delA	uc001sxw.2	-						NAP1L1_uc001sxv.2_Intron|NAP1L1_uc001sxz.2_3'UTR|NAP1L1_uc001sxx.2_3'UTR|NAP1L1_uc001sxy.2_3'UTR|NAP1L1_uc010sty.1_3'UTR|NAP1L1_uc010stz.1_3'UTR	NM_139207	NP_631946			nucleosome assembly protein 1-like 1						DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)																---	---	---	---
Unknown	0	broad.mit.edu	37	12	80655606	80655606	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:80655606delT								PPP1R12A (326371 upstream) : PTPRQ (182520 downstream)																																			---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81655693	81655694	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81655693_81655694delTT	uc001szo.1	-						PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_Intron|PPFIA2_uc010suh.1_Intron|PPFIA2_uc010suf.1_Intron|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616			PTPRF interacting protein alpha 2											ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
PPFIA2	8499	broad.mit.edu	37	12	81741691	81741691	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:81741691delT	uc001szo.1	-						PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_Intron|PPFIA2_uc010suh.1_Intron|PPFIA2_uc010sui.1_Intron|PPFIA2_uc010suj.1_Intron|PPFIA2_uc009zsi.1_Intron|PPFIA2_uc010suf.1_Intron|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616			PTPRF interacting protein alpha 2											ovary(3)|lung(2)|pancreas(1)	6																		---	---	---	---
RASSF9	9182	broad.mit.edu	37	12	86198389	86198390	+	3'UTR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:86198389_86198390insT	uc001taf.1	-	2						NM_005447	NP_005438			Ras association (RalGDS/AF-6) domain family						endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1																		---	---	---	---
C12orf29	91298	broad.mit.edu	37	12	88441883	88441884	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88441883_88441884delAA	uc001tao.2	+						C12orf29_uc001tap.2_Intron|C12orf29_uc009zsk.2_Intron	NM_001009894	NP_001009894			hypothetical protein LOC91298												0																		---	---	---	---
CEP290	80184	broad.mit.edu	37	12	88515039	88515039	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88515039delA	uc001tar.2	-						CEP290_uc001tat.2_Intron|CEP290_uc009zsl.1_Intron	NM_025114	NP_079390			centrosomal protein 290kDa						cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7																		---	---	---	---
DCN	1634	broad.mit.edu	37	12	91540129	91540138	+	Intron	DEL	TTTTTTTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:91540129_91540138delTTTTTTTTTT	uc001tbs.2	-						DCN_uc001tbo.2_Intron|DCN_uc001tbp.2_Intron|DCN_uc001tbq.2_Intron|DCN_uc001tbr.2_Intron|DCN_uc001tbt.2_Intron|DCN_uc001tbu.2_Intron	NM_133503	NP_598010			decorin isoform a preproprotein						organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4																		---	---	---	---
EEA1	8411	broad.mit.edu	37	12	93221850	93221850	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93221850delA	uc001tck.2	-							NM_003566	NP_003557			early endosome antigen 1, 162kD						early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94620799	94620800	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94620799_94620800insA	uc001tdc.2	+							NM_005761	NP_005752			plexin C1 precursor						axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
PLXNC1	10154	broad.mit.edu	37	12	94653399	94653401	+	In_Frame_Del	DEL	ACG	-	-	rs114497004	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94653399_94653401delACG	uc001tdc.2	+	19	3389_3391	c.3140_3142delACG	c.(3139-3144)AACGAC>AAC	p.D1048del	PLXNC1_uc010sut.1_In_Frame_Del_p.D95del|PLXNC1_uc009zsv.2_5'Flank	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1048	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
CCDC41	51134	broad.mit.edu	37	12	94703662	94703662	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:94703662delT	uc001tdd.2	-						CCDC41_uc001tde.2_Intron	NM_016122	NP_057206			NY-REN-58 antigen												0																		---	---	---	---
NEDD1	121441	broad.mit.edu	37	12	97339670	97339670	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:97339670delT	uc001teu.3	+						NEDD1_uc001tev.3_Intron|NEDD1_uc010svc.1_Intron|NEDD1_uc001tew.2_Intron|NEDD1_uc001tex.2_Intron	NM_152905	NP_690869			neural precursor cell expressed, developmentally						cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0																		---	---	---	---
SLC25A3	5250	broad.mit.edu	37	12	98989068	98989068	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:98989068delT	uc001tfo.2	+						SLC25A3_uc001tfm.2_Intron|SLC25A3_uc001tfn.2_Intron|SLC25A3_uc001tfp.2_Intron|SLC25A3_uc001tfq.2_Intron|SLC25A3_uc001tfr.2_Intron|SLC25A3_uc001tfs.2_5'UTR|SLC25A3_uc009ztn.2_Intron|SLC25A3_uc001tft.2_Intron	NM_005888	NP_005879			solute carrier family 25 member 3 isoform a						generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)														---	---	---	---
SCYL2	55681	broad.mit.edu	37	12	100709304	100709304	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:100709304delT	uc001thn.2	+						SCYL2_uc009ztw.1_Intron|SCYL2_uc001thm.1_Intron	NM_017988	NP_060458			SCY1-like 2 protein						endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6																		---	---	---	---
UTP20	27340	broad.mit.edu	37	12	101700374	101700374	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:101700374delT	uc001tia.1	+							NM_014503	NP_055318			down-regulated in metastasis						endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4																		---	---	---	---
NUP37	79023	broad.mit.edu	37	12	102492806	102492806	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:102492806delT	uc001tjc.2	-						NUP37_uc009zub.1_Intron	NM_024057	NP_076962			nucleoporin 37kDa						carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1																		---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104102402	104102403	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104102402_104102403insT	uc001tjw.2	+							NM_017564	NP_060034			stabilin 2 precursor						angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
NT5DC3	51559	broad.mit.edu	37	12	104171948	104171949	+	Intron	INS	-	A	A	rs57944247	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104171948_104171949insA	uc010swe.1	-						NT5DC3_uc010swd.1_5'Flank	NM_001031701	NP_001026871			5'-nucleotidase domain containing 3								hydrolase activity|metal ion binding			ovary(2)|skin(1)	3																		---	---	---	---
POLR3B	55703	broad.mit.edu	37	12	106799625	106799625	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:106799625delT	uc001tlp.2	+						POLR3B_uc001tlq.2_Intron	NM_018082	NP_060552			DNA-directed RNA polymerase III B isoform 1						innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
RIC8B	55188	broad.mit.edu	37	12	107279613	107279613	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:107279613delG	uc001tlx.2	+						RIC8B_uc001tly.2_Intron|RIC8B_uc001tlz.2_Intron|RIC8B_uc009zur.2_Intron	NM_018157	NP_060627			resistance to inhibitors of cholinesterase 8						regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
ACACB	32	broad.mit.edu	37	12	109683896	109683896	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109683896delA	uc001tob.2	+						ACACB_uc001toc.2_Intron|ACACB_uc010sxl.1_Intron|ACACB_uc001tod.2_Intron|ACACB_uc010sxm.1_Intron	NM_001093	NP_001084			acetyl-Coenzyme A carboxylase beta						acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)													---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109835725	109835725	+	Intron	DEL	A	-	-	rs111389226		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109835725delA	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109845512	109845512	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109845512delT	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
MYO1H	283446	broad.mit.edu	37	12	109845558	109845558	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109845558delT	uc010sxn.1	+							NM_001101421	NP_001094891			myosin 1H							myosin complex	motor activity				0																		---	---	---	---
UBE3B	89910	broad.mit.edu	37	12	109921643	109921643	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109921643delT	uc001top.2	+						UBE3B_uc001toq.2_Intron|UBE3B_uc001tol.1_Intron|UBE3B_uc001tom.2_Intron|UBE3B_uc001ton.2_Intron|UBE3B_uc001too.1_Intron|UBE3B_uc009zvj.1_Intron|UBE3B_uc001tor.2_Intron	NM_130466	NP_569733			ubiquitin protein ligase E3B						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4																		---	---	---	---
TRPV4	59341	broad.mit.edu	37	12	110221457	110221458	+	Frame_Shift_Ins	INS	-	G	G	rs149267166		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110221457_110221458insG	uc001tpj.1	-	15	2679_2680	c.2584_2585insC	c.(2584-2586)CGCfs	p.R862fs	TRPV4_uc001tpg.1_Frame_Shift_Ins_p.R828fs|TRPV4_uc001tph.1_Frame_Shift_Ins_p.R815fs|TRPV4_uc001tpi.1_Frame_Shift_Ins_p.R755fs|TRPV4_uc001tpk.1_Frame_Shift_Ins_p.R862fs|TRPV4_uc001tpl.1_Frame_Shift_Ins_p.R802fs	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	862	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
GIT2	9815	broad.mit.edu	37	12	110403605	110403605	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110403605delA	uc001tps.2	-						GIT2_uc001tpq.2_Intron|GIT2_uc001tpv.2_Intron|GIT2_uc001tpu.2_Intron|GIT2_uc001tpt.2_Intron|GIT2_uc010sxu.1_Intron|GIT2_uc001tpw.2_Intron|GIT2_uc010sxv.1_Intron	NM_057169	NP_476510			G protein-coupled receptor kinase interacting						regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
ANKRD13A	88455	broad.mit.edu	37	12	110461770	110461770	+	Intron	DEL	A	-	-	rs35432632		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110461770delA	uc001tpx.2	+						ANKRD13A_uc009zvl.1_Intron|ANKRD13A_uc010sxw.1_Intron|ANKRD13A_uc001tpy.2_5'Flank	NM_033121	NP_149112			ankyrin repeat domain 13												0																		---	---	---	---
ANKRD13A	88455	broad.mit.edu	37	12	110463770	110463770	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110463770delT	uc001tpx.2	+						ANKRD13A_uc009zvl.1_Intron|ANKRD13A_uc010sxw.1_Intron|ANKRD13A_uc001tpy.2_Intron|ANKRD13A_uc001tpz.2_5'Flank	NM_033121	NP_149112			ankyrin repeat domain 13												0																		---	---	---	---
ANKRD13A	88455	broad.mit.edu	37	12	110468604	110468604	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110468604delA	uc001tpx.2	+						ANKRD13A_uc010sxw.1_Intron|ANKRD13A_uc001tpy.2_Intron|ANKRD13A_uc001tpz.2_Intron|ANKRD13A_uc001tqa.2_Intron	NM_033121	NP_149112			ankyrin repeat domain 13												0																		---	---	---	---
PPTC7	160760	broad.mit.edu	37	12	110975056	110975056	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:110975056delA	uc001trh.1	-							NM_139283	NP_644812			T-cell activation protein phosphatase 2C								metal ion binding|phosphoprotein phosphatase activity				0																		---	---	---	---
ATXN2	6311	broad.mit.edu	37	12	111924631	111924631	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:111924631delA	uc001tsj.2	-						ATXN2_uc001tsh.2_Intron|ATXN2_uc001tsi.2_Intron|ATXN2_uc001tsk.2_Intron|ATXN2_uc001tsg.2_Intron	NM_002973	NP_002964			ataxin 2						cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2																		---	---	---	---
ACAD10	80724	broad.mit.edu	37	12	112143466	112143466	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112143466delT	uc001tsq.2	+						ACAD10_uc009zvw.2_Intron|ACAD10_uc001tso.3_Intron|ACAD10_uc001tsp.2_Intron|ACAD10_uc009zvx.2_Intron	NM_025247	NP_079523			acyl-Coenzyme A dehydrogenase family, member 10								acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2																		---	---	---	---
NAA25	80018	broad.mit.edu	37	12	112491483	112491483	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112491483delA	uc001ttm.2	-						NAA25_uc001ttn.3_Intron|NAA25_uc009zvz.1_Intron|NAA25_uc009zwa.1_Intron	NM_024953	NP_079229			mitochondrial distribution and morphology 20							cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3																		---	---	---	---
C12orf51	283450	broad.mit.edu	37	12	112687903	112687903	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112687903delT	uc009zwc.2	-						C12orf51_uc010syk.1_3'UTR|C12orf51_uc001tts.2_3'UTR|C12orf51_uc001ttt.3_3'UTR	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2																		---	---	---	---
RPL6	6128	broad.mit.edu	37	12	112848221	112848222	+	5'Flank	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112848221_112848222insA	uc001ttu.2	-						RPL6_uc001ttv.2_5'Flank|RPL6_uc009zwd.1_5'Flank	NM_001024662	NP_001019833			ribosomal protein L6						endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1																		---	---	---	---
RASAL1	8437	broad.mit.edu	37	12	113565725	113565725	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113565725delC	uc001tum.1	-						RASAL1_uc010syp.1_Intron|RASAL1_uc001tul.2_Intron|RASAL1_uc001tun.1_Intron|RASAL1_uc010syq.1_Intron|RASAL1_uc001tuo.3_Intron|RASAL1_uc010syr.1_Intron	NM_004658	NP_004649			RAS protein activator like 1						intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4																		---	---	---	---
SLC24A6	80024	broad.mit.edu	37	12	113748006	113748006	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113748006delC	uc001tvc.2	-						SLC24A6_uc001tuz.2_Intron|SLC24A6_uc001tva.2_Intron|SLC24A6_uc001tvb.2_Intron	NM_024959	NP_079235			solute carrier family 24 member 6 precursor						response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1																		---	---	---	---
PLBD2	196463	broad.mit.edu	37	12	113825651	113825652	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113825651_113825652insA	uc001tve.2	+	11	1577_1578	c.1542_1543insA	c.(1540-1545)GCCAATfs	p.A514fs	PLBD2_uc001tvf.2_Frame_Shift_Ins_p.A482fs	NM_173542	NP_775813	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2 isoform 1	514_515					lipid catabolic process	lysosomal lumen	hydrolase activity				0																		---	---	---	---
RBM19	9904	broad.mit.edu	37	12	114395612	114395612	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:114395612delT	uc009zwi.2	-	6	959	c.815delA	c.(814-816)AAGfs	p.K272fs	RBM19_uc001tvn.3_Frame_Shift_Del_p.K272fs|RBM19_uc001tvm.2_Frame_Shift_Del_p.K272fs	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	272					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)																	---	---	---	---
KSR2	283455	broad.mit.edu	37	12	118406112	118406112	+	5'Flank	DEL	A	-	-	rs7309205	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118406112delA	uc001two.2	-							NM_173598	NP_775869			kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
COQ5	84274	broad.mit.edu	37	12	120960838	120960838	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120960838delA	uc001tyn.2	-						COQ5_uc001tyo.2_Intron|COQ5_uc010szj.1_Intron	NM_032314	NP_115690			coenzyme Q5 homolog, methyltransferase						ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
C12orf43	64897	broad.mit.edu	37	12	121444027	121444027	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121444027delA	uc001tzh.1	-						C12orf43_uc009zxa.1_Intron|C12orf43_uc010szo.1_Intron|C12orf43_uc010szp.1_Intron|C12orf43_uc001tzi.1_Intron	NM_022895	NP_075046			hypothetical protein LOC64897												0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)																	---	---	---	---
MORN3	283385	broad.mit.edu	37	12	122097296	122097296	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122097296delG	uc001uax.2	-						MORN3_uc001uay.2_Intron	NM_173855	NP_776254			MORN repeat containing 3												0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000409)|Epithelial(86;0.00145)														---	---	---	---
WDR66	144406	broad.mit.edu	37	12	122362025	122362026	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122362025_122362026delTT	uc009zxk.2	+							NM_144668	NP_653269			WD repeat domain 66								calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)														---	---	---	---
LRRC43	254050	broad.mit.edu	37	12	122685346	122685346	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122685346delC	uc009zxm.2	+	10	1699	c.1674delC	c.(1672-1674)GACfs	p.D558fs	LRRC43_uc001ubw.3_Frame_Shift_Del_p.D373fs|LRRC43_uc009zxn.2_Frame_Shift_Del_p.D319fs|B3GNT4_uc001ubx.2_5'Flank|B3GNT4_uc001uby.2_5'Flank	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	558											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)														---	---	---	---
CLIP1	6249	broad.mit.edu	37	12	122838948	122838948	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122838948delA	uc001ucg.1	-						CLIP1_uc001uch.1_Intron|CLIP1_uc001uci.1_Intron|CLIP1_uc001ucj.1_Intron|CLIP1_uc009zxo.1_Intron|CLIP1_uc010tae.1_Intron	NM_002956	NP_002947			restin isoform a						mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)														---	---	---	---
ZCCHC8	55596	broad.mit.edu	37	12	122962860	122962860	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122962860delA	uc001ucn.2	-						ZCCHC8_uc001ucl.2_5'UTR|ZCCHC8_uc001ucm.2_Intron|ZCCHC8_uc009zxp.2_Intron|ZCCHC8_uc009zxq.2_Intron	NM_017612	NP_060082			zinc finger, CCHC domain containing 8							catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123031923	123031923	+	Intron	DEL	A	-	-	rs74554972		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123031923delA	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523			Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
KNTC1	9735	broad.mit.edu	37	12	123067169	123067170	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123067169_123067170insA	uc001ucv.2	+						KNTC1_uc010taf.1_Intron	NM_014708	NP_055523			Rough Deal homolog, centromere/kinetochore						cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)														---	---	---	---
DENR	8562	broad.mit.edu	37	12	123246767	123246767	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123246767delT	uc001uda.2	+						DENR_uc010tag.1_Intron|DENR_uc001udb.2_Intron	NM_003677	NP_003668			density-regulated protein								protein binding|translation initiation factor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.28e-05)|Epithelial(86;6.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.199)														---	---	---	---
HIP1R	9026	broad.mit.edu	37	12	123343928	123343928	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123343928delG	uc001udj.1	+						HIP1R_uc001udk.1_Intron	NM_003959	NP_003950			huntingtin interacting protein-1-related						receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)														---	---	---	---
HIP1R	9026	broad.mit.edu	37	12	123345087	123345087	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:123345087delG	uc001udj.1	+						HIP1R_uc001udk.1_Intron	NM_003959	NP_003950			huntingtin interacting protein-1-related						receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)												OREG0022225	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124337720	124337720	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124337720delT	uc001uft.3	+							NM_207437	NP_997320			dynein, axonemal, heavy chain 10						microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
NCOR2	9612	broad.mit.edu	37	12	124957687	124957687	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124957687delA	uc010tba.1	-						NCOR2_uc010tay.1_Intron|NCOR2_uc010taz.1_Intron|NCOR2_uc010tbb.1_Intron|NCOR2_uc010tbc.1_Intron|NCOR2_uc001ugj.1_Intron|NCOR2_uc001ugk.1_Intron	NM_001077261	NP_001070729			nuclear receptor co-repressor 2 isoform 2						cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)														---	---	---	---
FZD10	11211	broad.mit.edu	37	12	130649317	130649318	+	3'UTR	DEL	TT	-	-	rs112714527		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130649317_130649318delTT	uc001uii.2	+	1					uc001uih.1_5'Flank	NM_007197	NP_009128			frizzled 10 precursor						brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)														---	---	---	---
RIMBP2	23504	broad.mit.edu	37	12	130919596	130919598	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:130919596_130919598delTTT	uc001uil.2	-						RIMBP2_uc001uim.2_Intron|RIMBP2_uc001uin.1_Intron	NM_015347	NP_056162			RIM-binding protein 2							cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)														---	---	---	---
SFRS8	6433	broad.mit.edu	37	12	132198528	132198529	+	Intron	DEL	TA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132198528_132198529delTA	uc001uja.1	+						SFRS8_uc010tbn.1_Intron|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_Intron	NM_004592	NP_004583			splicing factor, arginine/serine-rich 8						mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)														---	---	---	---
ULK1	8408	broad.mit.edu	37	12	132398254	132398256	+	Intron	DEL	AAC	-	-	rs68126752		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:132398254_132398256delAAC	uc001uje.2	+							NM_003565	NP_003556			Unc-51-like kinase 1						autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)														---	---	---	---
GOLGA3	2802	broad.mit.edu	37	12	133378165	133378165	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133378165delG	uc001ukz.1	-						GOLGA3_uc001ula.1_Intron|GOLGA3_uc001ulb.2_Intron	NM_005895	NP_005886			Golgi autoantigen, golgin subfamily a, 3						intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	19747184	19747184	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19747184delT								DKFZp686A1627 (54761 upstream) : TUBA3C (736 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	19801216	19801216	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:19801216delT								TUBA3C (45280 upstream) : LOC100101938 (35725 downstream)																																			---	---	---	---
PSPC1	55269	broad.mit.edu	37	13	20325236	20325238	+	Intron	DEL	TTC	-	-	rs76697490	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:20325236_20325238delTTC	uc001uml.2	-						PSPC1_uc001umj.1_Intron|PSPC1_uc001umk.1_Intron	NM_001042414	NP_001035879			paraspeckle protein 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)	1		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)														---	---	---	---
ZDHHC20	253832	broad.mit.edu	37	13	21995144	21995144	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:21995144delA	uc001uob.2	-						ZDHHC20_uc001uod.2_Intron|ZDHHC20_uc001uoc.2_Intron|ZDHHC20_uc001uoe.2_Intron|ZDHHC20_uc010tcs.1_Intron	NM_153251	NP_694983			zinc finger, DHHC-type containing 20							integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		all_cancers(29;8.1e-16)|all_epithelial(30;3.63e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000268)|Epithelial(112;0.000735)|OV - Ovarian serous cystadenocarcinoma(117;0.00517)|Lung(94;0.171)														---	---	---	---
EFHA1	221154	broad.mit.edu	37	13	22095505	22095505	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:22095505delA	uc001uof.2	-							NM_152726	NP_689939			EF-hand domain family, member A1								calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)														---	---	---	---
PABPC3	5042	broad.mit.edu	37	13	25670214	25670214	+	5'Flank	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25670214delT	uc001upy.2	+							NM_030979	NP_112241			poly(A) binding protein, cytoplasmic 3						mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)														---	---	---	---
PABPC3	5042	broad.mit.edu	37	13	25672306	25672306	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25672306delA	uc001upy.2	+	1						NM_030979	NP_112241			poly(A) binding protein, cytoplasmic 3						mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)														---	---	---	---
RPL21	6144	broad.mit.edu	37	13	27830554	27830554	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:27830554delT	uc001ura.2	+							NM_000982	NP_000973			ribosomal protein L21						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome				0		Lung SC(185;0.0156)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0287)|OV - Ovarian serous cystadenocarcinoma(117;0.118)|Epithelial(112;0.139)|GBM - Glioblastoma multiforme(144;0.21)														---	---	---	---
USPL1	10208	broad.mit.edu	37	13	31195197	31195197	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31195197delT	uc001utc.2	+						USPL1_uc001utb.2_Intron|USPL1_uc001utd.2_Intron	NM_005800	NP_005791			ubiquitin specific peptidase like 1						ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)														---	---	---	---
HSPH1	10808	broad.mit.edu	37	13	31715420	31715421	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:31715420_31715421insA	uc001utj.2	-						HSPH1_uc001utk.2_Intron|HSPH1_uc010aaw.2_Intron|HSPH1_uc001utl.2_Intron|HSPH1_uc010tds.1_Intron	NM_006644	NP_006635			heat shock 105kD						positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)														---	---	---	---
PDS5B	23047	broad.mit.edu	37	13	33283975	33283975	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33283975delT	uc010abf.2	+						PDS5B_uc010abg.2_Intron	NM_015032	NP_055847			PDS5, regulator of cohesion maintenance, homolog						cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)														---	---	---	---
PDS5B	23047	broad.mit.edu	37	13	33306370	33306370	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:33306370delA	uc010abf.2	+						PDS5B_uc010abg.2_Intron	NM_015032	NP_055847			PDS5, regulator of cohesion maintenance, homolog						cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)														---	---	---	---
FREM2	341640	broad.mit.edu	37	13	39447134	39447134	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:39447134delT	uc001uwv.2	+							NM_207361	NP_997244			FRAS1-related extracellular matrix protein 2						cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)														---	---	---	---
COG6	57511	broad.mit.edu	37	13	40256199	40256199	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:40256199delT	uc001uxh.2	+						COG6_uc001uxi.2_Intron|COG6_uc010acb.2_Intron	NM_020751	NP_065802			component of oligomeric golgi complex 6 isoform						protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)														---	---	---	---
SUGT1L1	283507	broad.mit.edu	37	13	41398933	41398933	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41398933delA	uc001uxp.1	-							NR_003365				Homo sapiens cDNA FLJ35913 fis, clone TESTI2010239.												0																		---	---	---	---
MTRF1	9617	broad.mit.edu	37	13	41826691	41826691	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41826691delA	uc001uxx.2	-						MTRF1_uc001uxy.2_Intron|MTRF1_uc001uxz.2_Intron|MTRF1_uc010tff.1_Intron|MTRF1_uc001uyc.1_Intron	NM_004294	NP_004285			mitochondrial translational release factor 1						regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)														---	---	---	---
NAA16	79612	broad.mit.edu	37	13	41941505	41941505	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:41941505delT	uc001uyf.2	+						NAA16_uc010tfg.1_Intron	NM_024561	NP_078837			NMDA receptor regulated 1-like protein isoform						N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			central_nervous_system(1)	1																		---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42249231	42249231	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42249231delA	uc001uyj.2	-							NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42293886	42293886	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42293886delA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
KIAA0564	23078	broad.mit.edu	37	13	42361545	42361545	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:42361545delA	uc001uyj.2	-						KIAA0564_uc001uyk.2_Intron	NM_015058	NP_055873			hypothetical protein LOC23078 isoform a							extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)														---	---	---	---
TSC22D1	8848	broad.mit.edu	37	13	45150004	45150005	+	Frame_Shift_Ins	INS	-	G	G	rs145475008		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:45150004_45150005insG	uc001uzn.3	-	1	697_698	c.206_207insC	c.(205-207)CCTfs	p.P69fs	TSC22D1_uc001uzo.1_Frame_Shift_Ins_p.P69fs	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	69	Pro-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)														---	---	---	---
COG3	83548	broad.mit.edu	37	13	46067675	46067675	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46067675delA	uc001vak.2	+						COG3_uc001vai.2_3'UTR|COG3_uc001vaj.1_Intron|COG3_uc010tfv.1_Intron|COG3_uc010aci.2_Intron	NM_031431	NP_113619			component of golgi transport complex 3						ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)														---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49649272	49649272	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49649272delT	uc001vcm.2	+						FNDC3A_uc001vcl.1_Intron|FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
FNDC3A	22862	broad.mit.edu	37	13	49761480	49761480	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:49761480delT	uc001vcm.2	+						FNDC3A_uc001vcn.2_Intron|FNDC3A_uc001vco.2_Intron|FNDC3A_uc001vcp.1_Intron|FNDC3A_uc001vcq.2_Intron	NM_001079673	NP_001073141			fibronectin type III domain containing 3A							Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)														---	---	---	---
PHF11	51131	broad.mit.edu	37	13	50087175	50087175	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50087175delT	uc001vdb.2	+						PHF11_uc010tgl.1_Intron|PHF11_uc001vdc.2_Intron|PHF11_uc001vdd.2_Intron	NM_001040443	NP_001035533			PHD finger protein 11 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)														---	---	---	---
PHF11	51131	broad.mit.edu	37	13	50098427	50098428	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50098427_50098428delAA	uc001vdb.2	+						PHF11_uc001vdc.2_Intron|PHF11_uc001vdd.2_Intron	NM_001040443	NP_001035533			PHD finger protein 11 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding				0		Lung NSC(96;2.1e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.38e-09)														---	---	---	---
RCBTB1	55213	broad.mit.edu	37	13	50141513	50141513	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:50141513delA	uc001vde.1	-							NM_018191	NP_060661			regulator of chromosome condensation (RCC1) and						cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)														---	---	---	---
RNASEH2B	79621	broad.mit.edu	37	13	51527972	51527972	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51527972delT	uc001vfa.3	+						RNASEH2B_uc001vfb.3_Intron	NM_024570	NP_078846			ribonuclease H2, subunit B isoform 1						RNA catabolic process	nucleus|ribonuclease H2 complex					0		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)														---	---	---	---
INTS6	26512	broad.mit.edu	37	13	51936272	51936272	+	3'UTR	DEL	G	-	-	rs2408363	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:51936272delG	uc001vfk.2	-	18					SERPINE3_uc010tgp.1_Intron|INTS6_uc001vfi.2_3'UTR|INTS6_uc001vfj.2_3'UTR|INTS6_uc001vfl.2_3'UTR	NM_012141	NP_036273			integrator complex subunit 6 isoform a						snRNA processing	actin cytoskeleton|integrator complex	protein binding|transmembrane receptor activity			ovary(1)|lung(1)	2		Breast(56;0.000286)|Lung NSC(96;0.00145)|Prostate(109;0.00403)|Hepatocellular(98;0.065)|Myeloproliferative disorder(33;0.163)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;7.7e-08)														---	---	---	---
ATP7B	540	broad.mit.edu	37	13	52509214	52509214	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:52509214delT	uc001vfw.2	-						ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Intron|ATP7B_uc010tgu.1_Intron|ATP7B_uc010tgv.1_Intron|ATP7B_uc001vfv.2_Intron|ATP7B_uc010tgs.1_Intron	NM_000053	NP_000044			ATPase, Cu++ transporting, beta polypeptide						ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)										Wilson_disease				---	---	---	---
CKAP2	26586	broad.mit.edu	37	13	53042523	53042523	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:53042523delT	uc001vgv.2	+						CKAP2_uc001vgu.2_Intron|CKAP2_uc010tha.1_Intron	NM_001098525	NP_001091995			cytoskeleton associated protein 2 isoform 2						apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)														---	---	---	---
DIAPH3	81624	broad.mit.edu	37	13	60240695	60240695	+	3'UTR	DEL	T	-	-	rs111915155	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:60240695delT	uc001vht.2	-	28					DIAPH3_uc001vhs.2_RNA	NM_001042517	NP_001035982			diaphanous homolog 3 isoform a						actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)														---	---	---	---
KLHL1	57626	broad.mit.edu	37	13	70293600	70293600	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:70293600delC	uc001vip.2	-	9	2710	c.1916delG	c.(1915-1917)GGTfs	p.G639fs	KLHL1_uc010thm.1_Frame_Shift_Del_p.G578fs	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	639	Kelch 4.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)														---	---	---	---
C13orf34	79866	broad.mit.edu	37	13	73302973	73302973	+	Intron	DEL	G	-	-	rs76335732	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:73302973delG	uc001viv.1	+						C13orf37_uc001viu.2_5'Flank|C13orf34_uc010thq.1_Intron|C13orf34_uc010aen.1_Intron|C13orf34_uc010thr.1_Intron|C13orf34_uc001viw.1_Intron	NM_024808	NP_079084			aurora borealis						cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)														---	---	---	---
CLN5	1203	broad.mit.edu	37	13	77569390	77569391	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77569390_77569391delTT	uc001vkc.2	+							NM_006493	NP_006484			ceroid-lipofuscinosis, neuronal 5						brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77759988	77759988	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77759988delA	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
MYCBP2	23077	broad.mit.edu	37	13	77834802	77834802	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:77834802delA	uc001vkf.2	-						MYCBP2_uc010aev.2_Intron	NM_015057	NP_055872			MYC binding protein 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)														---	---	---	---
SCEL	8796	broad.mit.edu	37	13	78202069	78202069	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:78202069delT	uc001vki.2	+						SCEL_uc001vkj.2_Intron|SCEL_uc010thx.1_Intron	NM_144777	NP_659001			sciellin isoform 1						embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)														---	---	---	---
SLITRK1	114798	broad.mit.edu	37	13	84455772	84455772	+	5'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:84455772delG	uc001vlk.2	-	1						NM_052910	NP_443142			slit and trk like 1 protein precursor							integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)														---	---	---	---
Unknown	0	broad.mit.edu	37	13	86928881	86928881	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:86928881delA								SLITRK6 (555398 upstream) : None (None downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	13	88542299	88542299	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:88542299delT								SLITRK5 (210431 upstream) : None (None downstream)																																			---	---	---	---
DCT	1638	broad.mit.edu	37	13	95121040	95121040	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95121040delA	uc001vlv.3	-	2	982	c.555delT	c.(553-555)TTTfs	p.F185fs	DCT_uc010afh.2_Frame_Shift_Del_p.F185fs	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	185	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)														---	---	---	---
GPR180	160897	broad.mit.edu	37	13	95273242	95273243	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95273242_95273243delAA	uc001vly.2	+						GPR180_uc001vlz.2_Intron|GPR180_uc010afi.2_Intron	NM_180989	NP_851320			G protein-coupled receptor 180 precursor							integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)																	---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95696129	95696129	+	Intron	DEL	A	-	-	rs4148539		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95696129delA	uc001vmd.3	-						ABCC4_uc010afj.2_Intron|ABCC4_uc010afk.2_Intron	NM_005845	NP_005836			ATP-binding cassette, sub-family C, member 4						platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
ABCC4	10257	broad.mit.edu	37	13	95862712	95862712	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95862712delA	uc001vmd.3	-						ABCC4_uc010afk.2_Intron|ABCC4_uc001vme.2_Intron|ABCC4_uc010tih.1_Intron|ABCC4_uc001vmf.2_Intron|ABCC4_uc010afl.1_Intron|ABCC4_uc010afm.1_Intron	NM_005845	NP_005836			ATP-binding cassette, sub-family C, member 4						platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)													---	---	---	---
DZIP1	22873	broad.mit.edu	37	13	96246367	96246367	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96246367delA	uc001vmk.2	-						DZIP1_uc001vmj.2_Intron|DZIP1_uc001vml.2_Intron	NM_198968	NP_945319			DAZ interacting protein 1 isoform 2						germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)															---	---	---	---
UGGT2	55757	broad.mit.edu	37	13	96506782	96506782	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96506782delT	uc001vmt.2	-						UGGT2_uc001vms.2_Intron	NM_020121	NP_064506			UDP-glucose ceramide glucosyltransferase-like 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TNFSF13B	10673	broad.mit.edu	37	13	108955486	108955486	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108955486delT	uc001vqr.2	+						TNFSF13B_uc010agj.2_Intron|TNFSF13B_uc001vqs.1_Intron	NM_006573	NP_006564			tumor necrosis factor superfamily, member 13b						cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)															---	---	---	---
TUBGCP3	10426	broad.mit.edu	37	13	113219277	113219277	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113219277delA	uc001vse.1	-						TUBGCP3_uc010tjq.1_Intron|TUBGCP3_uc001vsf.2_Intron|TUBGCP3_uc001vsg.1_Intron	NM_006322	NP_006313			tubulin, gamma complex associated protein 3						G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)																	---	---	---	---
F10	2159	broad.mit.edu	37	13	113801712	113801712	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113801712delA	uc001vsx.2	+	7	824	c.767delA	c.(766-768)GAAfs	p.E256fs	F10_uc010agq.1_RNA|F10_uc001vsy.2_Frame_Shift_Del_p.E256fs|F10_uc001vsz.2_Frame_Shift_Del_p.E256fs	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	256	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
PCID2	55795	broad.mit.edu	37	13	113833166	113833167	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113833166_113833167delAA	uc010tju.1	-						PCID2_uc001vtb.2_Intron|PCID2_uc010tjv.1_Intron|PCID2_uc010tjw.1_Intron|PCID2_uc001vte.2_Intron|PCID2_uc001vtd.2_Intron|PCID2_uc001vtf.2_Intron	NM_001127203	NP_001120675			PCI domain containing 2						negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)															---	---	---	---
LAMP1	3916	broad.mit.edu	37	13	113964840	113964841	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113964840_113964841insA	uc001vtm.1	+						LAMP1_uc010tka.1_Intron	NM_005561	NP_005552			lysosomal-associated membrane protein 1							endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)															---	---	---	---
UPF3A	65110	broad.mit.edu	37	13	115057211	115057211	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:115057211delA	uc001vup.2	+	7	827	c.790delA	c.(790-792)AAAfs	p.K264fs	UPF3A_uc001vuq.2_Frame_Shift_Del_p.K231fs|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA|UPF3A_uc001vut.2_Frame_Shift_Del_p.K63fs|UPF3A_uc001vuu.2_5'UTR	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	264					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	19339542	19339542	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19339542delA								None (None upstream) : OR11H12 (38052 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	14	19468538	19468539	+	IGR	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:19468538_19468539insG								OR11H12 (89966 upstream) : POTEG (84826 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	14	21191414	21191414	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21191414delC								RNASE4 (22657 upstream) : EDDM3A (8446 downstream)																																			---	---	---	---
METT11D1	64745	broad.mit.edu	37	14	21461941	21461942	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21461941_21461942delTT	uc001vyn.2	+						METT11D1_uc001vym.2_Intron|METT11D1_uc001vyo.2_Intron|METT11D1_uc001vyp.2_Intron|METT11D1_uc001vyq.2_Intron	NM_022734	NP_073571			methyltransferase 11 domain containing 1 isoform						translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	22032020	22032021	+	IGR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:22032020_22032021insA								SALL2 (26683 upstream) : OR10G3 (5914 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	14	23020942	23020942	+	RNA	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23020942delT	uc001wcx.3	+	7		c.1253delT			uc001wdv.3_3'UTR|uc001wec.2_3'UTR|uc001wee.3_3'UTR|uc001wei.2_3'UTR|uc001wej.2_3'UTR|uc001wek.2_3'UTR|uc001wel.2_3'UTR|uc001wem.3_3'UTR|uc001wep.2_3'UTR|uc001weq.2_3'UTR|uc001wer.2_RNA|uc001weu.2_3'UTR|uc001wev.2_3'UTR|uc001wew.2_3'UTR|uc001wfe.2_3'UTR|uc001wfk.2_3'UTR|uc010ajy.1_3'UTR|uc001wfn.2_3'UTR|uc001wfp.2_3'UTR|uc001wfx.2_3'UTR|uc001wgd.2_3'UTR|uc001wge.3_3'UTR|uc010tmx.1_3'UTR|uc001wgh.2_3'UTR|uc001wgk.2_3'UTR					Homo sapiens mRNA for T cell receptor alpha variable 13, partial cds, clone: SEB 7.																														---	---	---	---
RBM23	55147	broad.mit.edu	37	14	23373608	23373610	+	Intron	DEL	TTT	-	-	rs77283564		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23373608_23373610delTTT	uc001whg.2	-						RBM23_uc001whh.2_Intron|RBM23_uc001whi.2_Intron|RBM23_uc010tne.1_Intron|RBM23_uc001whj.2_Intron|RBM23_uc001whk.1_Intron	NM_001077351	NP_001070819			RNA binding motif protein 23 isoform 1						mRNA processing	nucleus	nucleotide binding|RNA binding			skin(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)														---	---	---	---
PSMB5	5693	broad.mit.edu	37	14	23495175	23495175	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23495175delA	uc001wii.2	-	3					PSMB5_uc001wij.2_3'UTR|PSMB5_uc010tni.1_3'UTR	NM_002797	NP_002788			proteasome beta 5 subunit isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)													---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23528863	23528867	+	Intron	DEL	TTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23528863_23528867delTTTTT	uc001wit.3	-						CDH24_uc001wil.2_5'Flank|CDH24_uc010akf.2_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.3_Intron|ACIN1_uc001wip.3_Intron|ACIN1_uc001wiq.3_Intron|ACIN1_uc001wir.3_Intron|ACIN1_uc001wis.3_Intron|ACIN1_uc010akg.2_Intron	NM_014977	NP_055792			apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23535231	23535231	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23535231delA	uc001wit.3	-						ACIN1_uc001wio.3_Intron|ACIN1_uc001wip.3_Intron|ACIN1_uc001wiq.3_Intron|ACIN1_uc001wir.3_Intron|ACIN1_uc001wis.3_Intron|ACIN1_uc010akg.2_Intron	NM_014977	NP_055792			apoptotic chromatin condensation inducer 1						apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
THTPA	79178	broad.mit.edu	37	14	24026212	24026213	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24026212_24026213delCA	uc001wkh.3	+	2	616_617	c.246_247delCA	c.(244-249)CTCACAfs	p.L82fs	THTPA_uc001wkb.3_Intron|THTPA_uc001wkg.3_Frame_Shift_Del_p.L82fs|THTPA_uc010akr.2_Intron|THTPA_uc001wki.3_Frame_Shift_Del_p.L82fs	NM_001126339	NP_001119811	Q9BU02	THTPA_HUMAN	thiamine triphosphatase	82_83					dephosphorylation|generation of precursor metabolites and energy|thiamine metabolic process	cytosol|nucleolus|soluble fraction	thiamin-triphosphatase activity				0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00643)	Thiamine(DB00152)													---	---	---	---
RNF31	55072	broad.mit.edu	37	14	24618577	24618578	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24618577_24618578insT	uc001wmn.1	+						PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Intron|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Intron|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469			ring finger protein 31						CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)														---	---	---	---
IPO4	79711	broad.mit.edu	37	14	24654263	24654263	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24654263delT	uc001wmv.1	-						IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_Intron|IPO4_uc001wmx.1_Intron|IPO4_uc001wmy.1_Intron|IPO4_uc010tnz.1_Intron|IPO4_uc001wmw.1_Intron|IPO4_uc001wmz.1_Intron	NM_024658	NP_078934			importin 4						intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)														---	---	---	---
NFATC4	4776	broad.mit.edu	37	14	24839090	24839091	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24839090_24839091insG	uc001wpc.2	+	2	807_808	c.486_487insG	c.(484-489)GGTGGGfs	p.G162fs	NFATC4_uc010tok.1_Frame_Shift_Ins_p.G225fs|NFATC4_uc010tol.1_Frame_Shift_Ins_p.G225fs|NFATC4_uc010alr.2_Frame_Shift_Ins_p.G225fs|NFATC4_uc010als.2_Frame_Shift_Ins_p.G175fs|NFATC4_uc010tom.1_Frame_Shift_Ins_p.G175fs|NFATC4_uc010ton.1_Frame_Shift_Ins_p.G175fs|NFATC4_uc010too.1_Frame_Shift_Ins_p.G175fs|NFATC4_uc010alt.2_Frame_Shift_Ins_p.G194fs|NFATC4_uc010top.1_Frame_Shift_Ins_p.G194fs|NFATC4_uc010toq.1_Frame_Shift_Ins_p.G194fs|NFATC4_uc010alu.2_Intron|NFATC4_uc010tor.1_Frame_Shift_Ins_p.G162fs|NFATC4_uc010tos.1_Frame_Shift_Ins_p.G92fs|NFATC4_uc010tot.1_Frame_Shift_Ins_p.G150fs|NFATC4_uc010tou.1_Frame_Shift_Ins_p.G92fs|NFATC4_uc010tov.1_Frame_Shift_Ins_p.G150fs|NFATC4_uc010tow.1_Frame_Shift_Ins_p.G92fs|NFATC4_uc010alv.2_Frame_Shift_Ins_p.G150fs|NFATC4_uc010tox.1_Frame_Shift_Ins_p.G92fs|NFATC4_uc001wpd.2_5'Flank|NFATC4_uc010toy.1_5'Flank|NFATC4_uc010toz.1_5'Flank	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	162_163	Pro-rich.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)														---	---	---	---
SCFD1	23256	broad.mit.edu	37	14	31188518	31188518	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31188518delT	uc001wqm.1	+						SCFD1_uc001wqn.1_Intron|SCFD1_uc010tpg.1_Intron|SCFD1_uc010tph.1_Intron|SCFD1_uc010amf.1_Intron|SCFD1_uc010tpi.1_Intron|SCFD1_uc010ame.1_Intron	NM_016106	NP_057190			vesicle transport-related protein isoform a						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)														---	---	---	---
HECTD1	25831	broad.mit.edu	37	14	31606025	31606026	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31606025_31606026delTT	uc001wrc.1	-						HECTD1_uc001wrd.1_Intron	NM_015382	NP_056197			HECT domain containing 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)														---	---	---	---
HEATR5A	25938	broad.mit.edu	37	14	31819967	31819970	+	Intron	DEL	TTTG	-	-	rs72055697		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:31819967_31819970delTTTG	uc001wrf.3	-						HEATR5A_uc010ami.2_Intron|HEATR5A_uc001wrg.1_Intron|HEATR5A_uc010tpk.1_Intron	NM_015473	NP_056288			HEAT repeat containing 5A								binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)														---	---	---	---
EAPP	55837	broad.mit.edu	37	14	34985336	34985337	+	3'UTR	DEL	AA	-	-	rs144603764		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:34985336_34985337delAA	uc001wsd.1	-	6						NM_018453	NP_060923			E2F-associated phosphoprotein						negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)														---	---	---	---
EAPP	55837	broad.mit.edu	37	14	34993823	34993824	+	Intron	DEL	AA	-	-	rs78060227		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:34993823_34993824delAA	uc001wsd.1	-							NM_018453	NP_060923			E2F-associated phosphoprotein						negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)														---	---	---	---
SRP54	6729	broad.mit.edu	37	14	35470316	35470316	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:35470316delT	uc001wso.2	+						SRP54_uc010tpp.1_Intron|SRP54_uc010tpq.1_Intron	NM_003136	NP_003127			signal recognition particle 54kDa isoform 1						GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)														---	---	---	---
RALGAPA1	253959	broad.mit.edu	37	14	36159219	36159219	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36159219delA	uc001wti.2	-						RALGAPA1_uc001wtj.2_Intron|RALGAPA1_uc010tpv.1_Intron|RALGAPA1_uc010tpw.1_Intron|RALGAPA1_uc001wtk.1_Intron	NM_014990	NP_055805			Ral GTPase activating protein, alpha subunit 1						activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4																		---	---	---	---
SIP1	8487	broad.mit.edu	37	14	39603012	39603013	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39603012_39603013insT	uc001wuq.2	+						SIP1_uc001wur.2_Intron|SIP1_uc001wus.2_Intron|SIP1_uc010amx.2_Intron	NM_003616	NP_003607			SMN-interacting protein 1 isoform alpha						ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding				0	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0121)														---	---	---	---
TRAPPC6B	122553	broad.mit.edu	37	14	39627730	39627730	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39627730delT	uc001wut.1	-						TRAPPC6B_uc001wuu.1_Intron|TRAPPC6B_uc001wuv.1_Intron|TRAPPC6B_uc010tqd.1_Intron	NM_001079537	NP_001073005			trafficking protein particle complex 6B isoform						vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	guanylate cyclase activity|heme binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0128)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	44760816	44760816	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:44760816delA								None (None upstream) : FSCB (212539 downstream)																																			---	---	---	---
C14orf106	55320	broad.mit.edu	37	14	45686484	45686484	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:45686484delA	uc001wwf.2	-							NM_018353	NP_060823			chromosome 14 open reading frame 106						cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0																		---	---	---	---
SDCCAG1	9147	broad.mit.edu	37	14	50307352	50307352	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50307352delT	uc001wxc.2	-						SDCCAG1_uc010anj.1_Intron|SDCCAG1_uc010tqi.1_Intron|SDCCAG1_uc001wxe.2_Intron|SDCCAG1_uc010anq.1_Intron	NM_004713	NP_004704			serologically defined colon cancer antigen 1							cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)														---	---	---	---
SOS2	6655	broad.mit.edu	37	14	50655134	50655134	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50655134delA	uc001wxs.3	-						SOS2_uc010tql.1_Intron	NM_006939	NP_008870			son of sevenless homolog 2						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)																	---	---	---	---
SOS2	6655	broad.mit.edu	37	14	50670810	50670810	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50670810delT	uc001wxs.3	-						SOS2_uc010tql.1_Intron	NM_006939	NP_008870			son of sevenless homolog 2						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)																	---	---	---	---
SOS2	6655	broad.mit.edu	37	14	50671132	50671132	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50671132delA	uc001wxs.3	-						SOS2_uc010tql.1_Intron	NM_006939	NP_008870			son of sevenless homolog 2						apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)																	---	---	---	---
MAP4K5	11183	broad.mit.edu	37	14	50895476	50895476	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:50895476delA	uc001wya.2	-						MAP4K5_uc001wyb.2_Intron	NM_006575	NP_006566			mitogen-activated protein kinase kinase kinase						activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)																	---	---	---	---
PYGL	5836	broad.mit.edu	37	14	51383598	51383599	+	Intron	INS	-	GA	GA			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51383598_51383599insGA	uc001wyu.2	-						PYGL_uc010tqq.1_Intron|PYGL_uc001wyv.2_Intron|PYGL_uc010anz.1_Intron	NM_002863	NP_002854			liver glycogen phosphorylase isoform 1						glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)													---	---	---	---
GPR137C	283554	broad.mit.edu	37	14	53101641	53101641	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:53101641delT	uc001wzu.3	+						GPR137C_uc001wzt.3_Intron	NM_001099652	NP_001093122			G protein-coupled receptor 137C							integral to membrane					0	Breast(41;0.0716)																	---	---	---	---
SAMD4A	23034	broad.mit.edu	37	14	55231287	55231287	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55231287delT	uc001xbb.2	+						SAMD4A_uc001xbc.2_Intron|SAMD4A_uc001xbg.2_Intron	NM_015589	NP_056404			sterile alpha motif domain containing 4 isoform						positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0																		---	---	---	---
LGALS3	3958	broad.mit.edu	37	14	55605002	55605003	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:55605002_55605003insG	uc001xbr.2	+	3	409_410	c.258_259insG	c.(256-261)CCTGGGfs	p.P86fs		NM_002306	NP_002297	P17931	LEG3_HUMAN	galectin 3	86_87	8 X 9 AA tandem repeats of Y-P-G-X(3)-P- G-A.|6; approximate.				cell differentiation|innate immune response|mRNA processing|RNA splicing	mitochondrial inner membrane|plasma membrane|spliceosomal complex	IgE binding|sugar binding				0																		---	---	---	---
KTN1	3895	broad.mit.edu	37	14	56104387	56104387	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:56104387delA	uc001xcb.2	+						KTN1_uc001xce.2_Intron|KTN1_uc001xcc.2_Intron|KTN1_uc001xcd.2_Intron|KTN1_uc010trb.1_Intron|KTN1_uc001xcf.1_Intron	NM_182926	NP_891556			kinectin 1 isoform a						microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7								T	RET	papillary thryoid								---	---	---	---
C14orf37	145407	broad.mit.edu	37	14	58724374	58724374	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58724374delA	uc010tro.1	-						PSMA3_uc001xdj.1_Intron|PSMA3_uc001xdk.1_Intron	NM_001001872	NP_001001872			hypothetical protein LOC145407 precursor							integral to membrane	binding				0																		---	---	---	---
C14orf135	64430	broad.mit.edu	37	14	60592345	60592345	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60592345delT	uc001xer.3	+						C14orf135_uc001xeq.2_Intron|C14orf135_uc010apm.2_Intron	NM_022495	NP_071940			hepatitis C virus F protein-binding protein 2							integral to membrane				ovary(2)	2		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	61068814	61068814	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61068814delT								SIX6 (90291 upstream) : SIX1 (42604 downstream)																																			---	---	---	---
SIX4	51804	broad.mit.edu	37	14	61180924	61180924	+	Intron	DEL	A	-	-	rs35020088		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61180924delA	uc001xfc.2	-							NM_017420	NP_059116			sine oculis homeobox homolog 4							nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)														---	---	---	---
PRKCH	5583	broad.mit.edu	37	14	61857924	61857924	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:61857924delT	uc001xfn.2	+						PRKCH_uc010tsa.1_Intron	NM_006255	NP_006246			protein kinase C, eta						intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)														---	---	---	---
HIF1A	3091	broad.mit.edu	37	14	62212360	62212360	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:62212360delA	uc001xfq.2	+						HIF1A_uc001xfr.2_Intron|HIF1A_uc001xfs.2_Intron	NM_001530	NP_001521			hypoxia-inducible factor 1, alpha subunit						cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64450478	64450478	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64450478delA	uc001xgm.2	+	18	2255	c.2025delA	c.(2023-2025)ATAfs	p.I675fs	SYNE2_uc001xgl.2_Frame_Shift_Del_p.I675fs	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	675	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
SYNE2	23224	broad.mit.edu	37	14	64632237	64632237	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:64632237delT	uc001xgm.2	+						SYNE2_uc001xgl.2_Intron|SYNE2_uc010apy.2_Intron|SYNE2_uc001xgn.2_Intron|SYNE2_uc001xgo.2_Intron|SYNE2_uc010aqa.2_Intron|SYNE2_uc001xgq.2_5'Flank	NM_015180	NP_055995			spectrin repeat containing, nuclear envelope 2						centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)														---	---	---	---
C14orf50	145376	broad.mit.edu	37	14	65017760	65017760	+	Intron	DEL	A	-	-	rs76585972	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65017760delA	uc001xhl.1	+							NM_172365	NP_758953			hypothetical protein LOC145376											skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)														---	---	---	---
MAX	4149	broad.mit.edu	37	14	65543066	65543066	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:65543066delA	uc001xif.1	-	5					MAX_uc001xic.1_Intron|MAX_uc001xie.1_3'UTR|MAX_uc010aql.1_3'UTR|MAX_uc001xig.1_3'UTR|MAX_uc001xih.1_RNA	NM_002382	NP_002373			MAX protein isoform a						transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			lung(1)	1				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)														---	---	---	---
FUT8	2530	broad.mit.edu	37	14	66135890	66135890	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:66135890delA	uc001xin.2	+						FUT8_uc001xio.2_Intron|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_Intron|FUT8_uc001xip.2_Intron|FUT8_uc001xiq.2_Intron|FUT8_uc001xis.2_5'Flank	NM_178155	NP_835368			fucosyltransferase 8 isoform a						in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)														---	---	---	---
ATP6V1D	51382	broad.mit.edu	37	14	67805495	67805495	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:67805495delG	uc001xjf.2	-						ATP6V1D_uc001xje.2_Intron	NM_015994	NP_057078			H(+)-transporting two-sector ATPase						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)														---	---	---	---
ZFYVE26	23503	broad.mit.edu	37	14	68244576	68244576	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:68244576delT	uc001xka.2	-						ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.3_Intron	NM_015346	NP_056161			zinc finger, FYVE domain containing 26						cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)														---	---	---	---
SMOC1	64093	broad.mit.edu	37	14	70351984	70351986	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:70351984_70351986delTTT	uc001xls.1	+						SMOC1_uc001xlt.1_Intron	NM_022137	NP_071420			secreted modular calcium-binding protein 1						cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71493712	71493712	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71493712delA	uc001xmo.2	+						PCNX_uc010are.1_Intron|PCNX_uc010arf.1_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71540602	71540602	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71540602delT	uc001xmo.2	+						PCNX_uc010are.1_Intron|PCNX_uc010arf.1_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
PCNX	22990	broad.mit.edu	37	14	71568998	71568998	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:71568998delT	uc001xmo.2	+						PCNX_uc010are.1_Intron|PCNX_uc010arf.1_Intron|PCNX_uc001xmp.2_Intron	NM_014982	NP_055797			pecanex-like 1							integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)														---	---	---	---
RGS6	9628	broad.mit.edu	37	14	72921100	72921100	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:72921100delA	uc001xna.3	+						RGS6_uc010ttn.1_Intron|RGS6_uc001xmx.3_Intron|RGS6_uc010tto.1_Intron|RGS6_uc001xmy.3_Intron|RGS6_uc010ttp.1_Intron|RGS6_uc010arg.2_Intron	NM_004296	NP_004287			regulator of G-protein signalling 6						G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)														---	---	---	---
DPF3	8110	broad.mit.edu	37	14	73137762	73137762	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73137762delA	uc001xnc.2	-						DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_3'UTR|DPF3_uc010ttq.1_3'UTR	NM_012074	NP_036206			D4, zinc and double PHD fingers, family 3						chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)														---	---	---	---
DNAL1	83544	broad.mit.edu	37	14	74153808	74153808	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74153808delA	uc001xoq.3	+						DNAL1_uc010aru.2_Intron|DNAL1_uc010arv.2_Intron	NM_031427	NP_113615			axonemal dynein light chain 1												0				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)														---	---	---	---
Unknown	0	broad.mit.edu	37	14	74865395	74865396	+	IGR	DEL	CA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74865395_74865396delCA								C14orf115 (38685 upstream) : TMEM90A (7200 downstream)																																			---	---	---	---
KIAA0317	9870	broad.mit.edu	37	14	75137987	75137988	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75137987_75137988delTT	uc001xqb.2	-						KIAA0317_uc010tut.1_Intron|KIAA0317_uc001xqc.2_Intron	NM_001039479	NP_001034568			hypothetical protein LOC9870						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)														---	---	---	---
YLPM1	56252	broad.mit.edu	37	14	75287731	75287734	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75287731_75287734delTTTT	uc001xqj.3	+						YLPM1_uc001xql.3_Intron|YLPM1_uc001xqm.1_Intron	NM_019589	NP_062535			YLP motif containing 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)														---	---	---	---
NEK9	91754	broad.mit.edu	37	14	75585642	75585642	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75585642delA	uc001xrl.2	-						NEK9_uc001xrk.2_5'Flank	NM_033116	NP_149107			NIMA-related kinase 9						cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)														---	---	---	---
ZDHHC22	283576	broad.mit.edu	37	14	77600151	77600151	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77600151delC	uc010asp.2	-	3	870	c.667delG	c.(667-669)GTGfs	p.V223fs		NM_174976	NP_777636	Q8N966	ZDH22_HUMAN	zinc finger, DHHC domain containing 22	223						integral to membrane	acyltransferase activity|zinc ion binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)														---	---	---	---
AHSA1	10598	broad.mit.edu	37	14	77932171	77932171	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:77932171delT	uc001xtw.2	+						AHSA1_uc010tvk.1_Intron	NM_012111	NP_036243			activator of heat shock 90kDa protein ATPase						protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81304459	81304459	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81304459delT	uc001xux.2	-						C14orf145_uc010asz.1_5'Flank|C14orf145_uc001xuz.2_Intron|C14orf145_uc001xuy.1_Intron	NM_152446	NP_689659			hypothetical protein LOC145508							centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
C14orf145	145508	broad.mit.edu	37	14	81307131	81307131	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81307131delA	uc001xux.2	-						C14orf145_uc001xuz.2_Intron|C14orf145_uc001xuy.1_Intron	NM_152446	NP_689659			hypothetical protein LOC145508							centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)														---	---	---	---
GTF2A1	2957	broad.mit.edu	37	14	81658772	81658773	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81658772_81658773insA	uc001xvf.1	-						GTF2A1_uc010atb.1_Intron|GTF2A1_uc001xvg.1_Intron	NM_015859	NP_056943			TFIIA alpha, p55 isoform 1						regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|transcription factor TFIIA complex	DNA binding|protein binding|protein heterodimerization activity|TBP-class protein binding|transcription coactivator activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0287)														---	---	---	---
SEL1L	6400	broad.mit.edu	37	14	81964078	81964078	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:81964078delT	uc010tvv.1	-							NM_005065	NP_005056			sel-1 suppressor of lin-12-like precursor						Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0299)														---	---	---	---
CALM1	801	broad.mit.edu	37	14	90871130	90871130	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:90871130delA	uc001xyl.1	+	6					CALM1_uc010atq.1_3'UTR|CALM1_uc010atr.1_RNA|CALM1_uc001xym.1_3'UTR	NM_006888	NP_008819			calmodulin 1 isoform 1						activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)													---	---	---	---
SMEK1	55671	broad.mit.edu	37	14	91931847	91931847	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:91931847delA	uc001xzn.2	-						SMEK1_uc001xzm.2_Intron|SMEK1_uc001xzo.2_Intron|SMEK1_uc010atz.2_Intron|SMEK1_uc001xzp.1_Intron	NM_032560	NP_115949			SMEK homolog 1, suppressor of mek1							microtubule organizing center|nucleus	protein binding				0		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)														---	---	---	---
BTBD7	55727	broad.mit.edu	37	14	93709467	93709467	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93709467delA	uc001ybo.2	-						BTBD7_uc010aur.2_Intron|BTBD7_uc010two.1_Intron|BTBD7_uc001ybp.2_Intron	NM_001002860	NP_001002860			BTB (POZ) domain containing 7 isoform 1											pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)														---	---	---	---
BTBD7	55727	broad.mit.edu	37	14	93709547	93709547	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93709547delT	uc001ybo.2	-						BTBD7_uc010aur.2_Intron|BTBD7_uc010two.1_Intron|BTBD7_uc001ybp.2_Intron	NM_001002860	NP_001002860			BTB (POZ) domain containing 7 isoform 1											pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)														---	---	---	---
KIAA1409	57578	broad.mit.edu	37	14	93814291	93814291	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:93814291delT	uc001ybs.1	+						COX8C_uc001ybt.1_Intron	NM_020818	NP_065869			hypothetical protein LOC57578							integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)														---	---	---	---
DICER1	23405	broad.mit.edu	37	14	95591010	95591010	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95591010delA	uc001ydw.2	-						DICER1_uc001ydv.2_Intron|DICER1_uc001ydx.2_Intron	NM_030621	NP_085124			dicer1						negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)				Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96757340	96757340	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96757340delT	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
AK7	122481	broad.mit.edu	37	14	96875210	96875211	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96875210_96875211insA	uc001yfn.2	+	4	474_475	c.430_431insA	c.(430-432)GAAfs	p.E144fs		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	144	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)														---	---	---	---
PAPOLA	10914	broad.mit.edu	37	14	96998599	96998599	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96998599delT	uc001yfq.2	+						PAPOLA_uc001yfp.2_Intron|PAPOLA_uc001yfr.2_Intron|PAPOLA_uc010twv.1_Intron|PAPOLA_uc010avp.2_Intron	NM_032632	NP_116021			poly(A) polymerase alpha						mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)														---	---	---	---
EML1	2009	broad.mit.edu	37	14	100344632	100344632	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:100344632delA	uc001ygs.2	+						EML1_uc010avt.1_Intron|EML1_uc010tww.1_Intron|EML1_uc001ygq.2_Intron|EML1_uc001ygr.2_Intron	NM_004434	NP_004425			echinoderm microtubule associated protein like 1							cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			large_intestine(2)|pancreas(1)|ovary(1)|skin(1)	5		Melanoma(154;0.0879)|all_epithelial(191;0.216)																---	---	---	---
DLK1	8788	broad.mit.edu	37	14	101194869	101194869	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:101194869delA	uc001yhs.3	+						DLK1_uc001yhu.3_Intron	NM_003836	NP_003827			delta-like 1 homolog precursor						multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)																---	---	---	---
DYNC1H1	1778	broad.mit.edu	37	14	102476416	102476416	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102476416delT	uc001yks.2	+	30	6378	c.6214delT	c.(6214-6216)TTTfs	p.F2072fs		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2072	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10																		---	---	---	---
HSP90AA1	3320	broad.mit.edu	37	14	102548312	102548312	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102548312delA	uc001yku.3	-						HSP90AA1_uc001ykv.3_Intron	NM_005348	NP_005339			heat shock 90kDa protein 1, alpha isoform 2						axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)													---	---	---	---
Unknown	0	broad.mit.edu	37	14	103615614	103615614	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:103615614delA								TNFAIP2 (11838 upstream) : EIF5 (184879 downstream)																																			---	---	---	---
KIF26A	26153	broad.mit.edu	37	14	104642584	104642584	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:104642584delG	uc001yos.3	+	12	3459	c.3459delG	c.(3457-3459)CTGfs	p.L1153fs		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1153					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	20662978	20662978	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:20662978delA	uc001ytg.2	-						uc010tyx.1_Intron|uc001yth.3_Intron|uc010tyy.1_Intron|uc010tyz.1_Intron					RecName: Full=Putative HERC2-like protein 3;																														---	---	---	---
TUBGCP5	114791	broad.mit.edu	37	15	22870060	22870060	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22870060delT	uc001yur.3	+						TUBGCP5_uc001yuq.2_Intron	NM_052903	NP_443135			tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)														---	---	---	---
CYFIP1	23191	broad.mit.edu	37	15	22933500	22933511	+	Intron	DEL	TTTTTTTTTTTA	-	-	rs1867599		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22933500_22933511delTTTTTTTTTTTA	uc001yus.2	+						CYFIP1_uc001yut.2_Intron|CYFIP1_uc010aya.1_Intron	NM_014608	NP_055423			cytoplasmic FMR1 interacting protein 1 isoform						axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)														---	---	---	---
SNORD116-4	100033416	broad.mit.edu	37	15	25310401	25310401	+	Intron	DEL	A	-	-	rs141858980		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25310401delA	uc001yxh.1	+						SNORD116-4_uc001yxm.1_Intron|IPW_uc001yxn.3_Intron|SNORD116-5_uc001yxq.2_5'Flank					Homo sapiens clone kid4 SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0																		---	---	---	---
UBE3A	7337	broad.mit.edu	37	15	25584238	25584238	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25584238delT	uc001zaq.2	-	11					uc001zae.2_Intron|UBE3A_uc001zar.2_3'UTR|UBE3A_uc001zas.2_3'UTR|UBE3A_uc001zat.2_3'UTR	NM_000462	NP_000453			ubiquitin protein ligase E3A isoform 2						brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	26654871	26654873	+	IGR	DEL	AAA	-	-	rs113031284		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:26654871_26654873delAAA								ATP10A (544554 upstream) : GABRB3 (133822 downstream)																																			---	---	---	---
GABRB3	2562	broad.mit.edu	37	15	26828380	26828381	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:26828380_26828381insA	uc001zaz.2	-						GABRB3_uc010uae.1_Intron|GABRB3_uc001zba.2_Intron|GABRB3_uc001zbb.2_Intron	NM_000814	NP_000805			gamma-aminobutyric acid (GABA) A receptor, beta						synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)													---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28473276	28473277	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28473276_28473277delAA	uc001zbj.2	-							NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28491745	28491747	+	Intron	DEL	AAA	-	-	rs139539730		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28491745_28491747delAAA	uc001zbj.2	-							NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28499435	28499435	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28499435delA	uc001zbj.2	-							NM_004667	NP_004658			hect domain and RLD 2						DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
WHAMML2	440253	broad.mit.edu	37	15	28986431	28986431	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28986431delT	uc010azf.2	+						WHAMML2_uc010uap.1_Splice_Site|WHAMML2_uc010azg.1_Intron|WHAMML2_uc010azh.1_Intron|WHAMML2_uc001zci.1_Intron					Homo sapiens WAS protein homology region 2 domain containing 1-like 2, mRNA (cDNA clone IMAGE:5261987).												0																		---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31293996	31293996	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31293996delA	uc001zfm.2	-	27					TRPM1_uc010azy.2_3'UTR|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411			transient receptor potential cation channel,						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
TRPM1	4308	broad.mit.edu	37	15	31294935	31294936	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31294935_31294936insT	uc001zfm.2	-	27	4029_4030	c.3901_3902insA	c.(3901-3903)ACCfs	p.T1301fs	TRPM1_uc010azy.2_Frame_Shift_Ins_p.T1208fs|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1301	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)														---	---	---	---
RYR3	6263	broad.mit.edu	37	15	34157542	34157542	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34157542delA	uc001zhi.2	+	104					RYR3_uc010bar.2_3'UTR	NM_001036	NP_001027			ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)														---	---	---	---
ATPBD4	89978	broad.mit.edu	37	15	35834516	35834517	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:35834516_35834517insT	uc001zja.2	-						ATPBD4_uc001ziz.2_Intron|ATPBD4_uc001zjb.2_Intron	NM_080650	NP_542381			ATP binding domain 4 isoform 1												0		all_epithelial(112;2.11e-09)|Lung NSC(122;2.38e-08)|all_lung(180;3.65e-07)		all cancers(64;9.9e-19)|GBM - Glioblastoma multiforme(113;2.01e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)														---	---	---	---
C15orf41	84529	broad.mit.edu	37	15	36910399	36910399	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:36910399delA	uc001zje.3	+						C15orf41_uc001zjd.2_Intron|C15orf41_uc010bbb.1_Intron|C15orf41_uc001zjf.2_Intron	NM_001130010	NP_001123482			hypothetical protein LOC84529 isoform 1								protein binding			pancreas(1)	1		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)														---	---	---	---
MEIS2	4212	broad.mit.edu	37	15	37328933	37328933	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:37328933delA	uc001zjr.2	-						MEIS2_uc001zjl.2_Intron|MEIS2_uc010ucj.1_Intron|MEIS2_uc001zjm.2_Intron|MEIS2_uc001zjn.2_Intron|MEIS2_uc001zjo.2_Intron|MEIS2_uc001zjp.2_Intron|MEIS2_uc001zjs.2_Intron|MEIS2_uc001zju.2_Intron|MEIS2_uc001zjt.2_Intron	NM_170675	NP_733775			Meis homeobox 2 isoform c						negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)														---	---	---	---
TMCO5A	145942	broad.mit.edu	37	15	38233712	38233712	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:38233712delA	uc001zjw.2	+						TMCO5A_uc001zjv.1_Intron|TMCO5A_uc010bbc.1_Intron	NM_152453	NP_689666			transmembrane and coiled-coil domains 5A							integral to membrane				central_nervous_system(1)	1																		---	---	---	---
THBS1	7057	broad.mit.edu	37	15	39875816	39875817	+	Splice_Site	INS	-	G	G	rs112381547		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:39875816_39875817insG	uc001zkh.2	+	4	807	c.628_splice	c.e4-1	p.G210_splice		NM_003246	NP_003237			thrombospondin 1 precursor						activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)											OREG0023051	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FSIP1	161835	broad.mit.edu	37	15	40062826	40062827	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40062826_40062827delAA	uc001zki.2	-							NM_152597	NP_689810			fibrous sheath interacting protein 1											ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)														---	---	---	---
C15orf57	90416	broad.mit.edu	37	15	40849315	40849316	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:40849315_40849316insA	uc001zmc.1	-						uc001zlx.1_RNA|C15orf57_uc001zly.2_Intron|C15orf57_uc001zma.1_Intron|C15orf57_uc001zmb.1_Intron|C15orf57_uc010bbr.2_3'UTR	NM_001080792	NP_001074261			coiled-coil domain containing 32 isoform a											ovary(1)	1																		---	---	---	---
INO80	54617	broad.mit.edu	37	15	41377755	41377755	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41377755delT	uc001zni.2	-	7	898	c.685delA	c.(685-687)AGAfs	p.R229fs	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	229	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.|Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
INO80	54617	broad.mit.edu	37	15	41387662	41387663	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41387662_41387663insA	uc001zni.2	-						INO80_uc010ucu.1_Intron	NM_017553	NP_060023			INO80 complex homolog 1						cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	41679507	41679509	+	IGR	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:41679507_41679509delAAA								NUSAP1 (6260 upstream) : NDUFAF1 (44 downstream)																																			---	---	---	---
UBR1	197131	broad.mit.edu	37	15	43252854	43252855	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43252854_43252855insT	uc001zqq.2	-	43	4811_4812	c.4745_4746insA	c.(4744-4746)AACfs	p.N1582fs		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1582					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)														---	---	---	---
TUBGCP4	27229	broad.mit.edu	37	15	43692574	43692574	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43692574delA	uc001zro.2	+						TUBGCP4_uc001zrn.2_Intron|TUBGCP4_uc010bdh.2_Intron	NM_014444	NP_055259			tubulin, gamma complex associated protein 4						G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)														---	---	---	---
ELL3	80237	broad.mit.edu	37	15	44067474	44067474	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44067474delA	uc001zsw.1	-						ELL3_uc001zsv.1_Intron|ELL3_uc001zsx.1_Intron|uc001zsy.2_5'Flank	NM_025165	NP_079441			elongation factor RNA polymerase II-like 3						positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)														---	---	---	---
CTDSPL2	51496	broad.mit.edu	37	15	44811330	44811331	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44811330_44811331delTT	uc001ztr.2	+						CTDSPL2_uc001zts.2_Intron|CTDSPL2_uc001ztt.2_Intron|CTDSPL2_uc010bdv.2_Intron	NM_016396	NP_057480			CTD (carboxy-terminal domain, RNA polymerase II,								phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)														---	---	---	---
EIF3J	8669	broad.mit.edu	37	15	44852434	44852434	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44852434delT	uc001ztv.2	+						EIF3J_uc010ueg.1_Intron|EIF3J_uc001ztw.2_Intron	NM_003758	NP_003749			eukaryotic translation initiation factor 3,							cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)														---	---	---	---
B2M	567	broad.mit.edu	37	15	45003781	45003782	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:45003781_45003782delCT	uc001zuc.2	+	1	97_98	c.37_38delCT	c.(37-39)CTCfs	p.L13fs	B2M_uc010uek.1_Frame_Shift_Del_p.L13fs|B2M_uc010bdx.1_Frame_Shift_Del_p.L13fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	13					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)														---	---	---	---
DUT	1854	broad.mit.edu	37	15	48634180	48634180	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:48634180delA	uc001zws.2	+						DUT_uc001zwt.2_Intron|DUT_uc001zwu.2_Intron|DUT_uc001zwv.2_3'UTR|DUT_uc001zww.2_Intron	NM_001025248	NP_001020419			deoxyuridine triphosphatase isoform 1 precursor						DNA replication|dUTP metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process	mitochondrion|nucleoplasm	dUTP diphosphatase activity|protein binding				0		all_lung(180;0.00265)		all cancers(107;2.66e-09)|GBM - Glioblastoma multiforme(94;6.76e-07)									Modulation_of_nucleotide_pools					---	---	---	---
ATP8B4	79895	broad.mit.edu	37	15	50399074	50399074	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:50399074delA	uc001zxu.2	-						ATP8B4_uc010ber.2_Intron|ATP8B4_uc010ufd.1_Intron|ATP8B4_uc010ufe.1_Intron	NM_024837	NP_079113			ATPase class I type 8B member 4						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)														---	---	---	---
SPPL2A	84888	broad.mit.edu	37	15	51017382	51017383	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51017382_51017383delTT	uc001zyv.2	-							NM_032802	NP_116191			signal peptide peptidase-like 2A							integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)														---	---	---	---
AP4E1	23431	broad.mit.edu	37	15	51221320	51221321	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51221320_51221321insG	uc001zyx.1	+	6	687_688	c.657_658insG	c.(655-660)GTTGGGfs	p.V219fs	AP4E1_uc010ufi.1_Frame_Shift_Ins_p.V219fs|AP4E1_uc010ufj.1_RNA|AP4E1_uc010ufk.1_RNA	NM_007347	NP_031373	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1	219_220					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity				0				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)														---	---	---	---
MYO5A	4644	broad.mit.edu	37	15	52680071	52680072	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:52680071_52680072delTT	uc002aby.2	-	14	1950_1951	c.1706_1707delAA	c.(1705-1707)AAAfs	p.K569fs	MYO5A_uc002abx.3_Frame_Shift_Del_p.K569fs|MYO5A_uc010uge.1_Frame_Shift_Del_p.K438fs	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	569	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54915983	54915983	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54915983delT	uc002ack.2	+						UNC13C_uc002acm.2_Intron	NM_001080534	NP_001074003			unc-13 homolog C						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55653148	55653148	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55653148delT	uc002acv.1	-						CCPG1_uc002acy.2_Intron|CCPG1_uc002acu.1_Intron|CCPG1_uc002acw.1_Intron|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Intron|CCPG1_uc002acz.1_Intron	NM_020739	NP_065790			cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
CCPG1	9236	broad.mit.edu	37	15	55677766	55677766	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:55677766delA	uc002acv.1	-						CCPG1_uc002acy.2_Intron|DYX1C1_uc010ugh.1_Intron|CCPG1_uc002acw.1_Intron|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Intron|CCPG1_uc002acz.1_Intron	NM_020739	NP_065790			cell cycle progression 1 isoform 2						cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)														---	---	---	---
NEDD4	4734	broad.mit.edu	37	15	56144502	56144503	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56144502_56144503delAA	uc002adj.2	-						NEDD4_uc002adl.2_Intron|NEDD4_uc002adi.2_Intron|NEDD4_uc010ugj.1_Intron|NEDD4_uc010bfm.2_Intron|NEDD4_uc002adk.2_Intron	NM_198400	NP_006145			neural precursor cell expressed, developmentally						development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)														---	---	---	---
ZNF280D	54816	broad.mit.edu	37	15	56969746	56969746	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:56969746delA	uc002adu.2	-						ZNF280D_uc002adv.2_Intron|ZNF280D_uc010bfq.2_Intron|ZNF280D_uc002adw.1_Intron|ZNF280D_uc010bfr.1_Intron|ZNF280D_uc010bfp.2_Intron	NM_017661	NP_060131			suppressor of hairy wing homolog 4 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)														---	---	---	---
FAM81A	145773	broad.mit.edu	37	15	59801187	59801187	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59801187delA	uc002agc.2	+							NM_152450	NP_689663			hypothetical protein LOC145773											ovary(1)	1																		---	---	---	---
BNIP2	663	broad.mit.edu	37	15	59961435	59961435	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59961435delA	uc010uhc.1	-						BNIP2_uc002agi.3_5'Flank|BNIP2_uc010uhb.1_Intron	NM_004330	NP_004321			BCL2/adenovirus E1B 19kD interacting protein 2						anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1																		---	---	---	---
BNIP2	663	broad.mit.edu	37	15	59972354	59972357	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:59972354_59972357delTTTT	uc010uhc.1	-						BNIP2_uc010uhb.1_Intron	NM_004330	NP_004321			BCL2/adenovirus E1B 19kD interacting protein 2						anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1																		---	---	---	---
VPS13C	54832	broad.mit.edu	37	15	62269403	62269403	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:62269403delA	uc002agz.2	-						VPS13C_uc002aha.2_Intron|VPS13C_uc002ahb.1_Intron|VPS13C_uc002ahc.1_Intron	NM_020821	NP_065872			vacuolar protein sorting 13C protein isoform 2A						protein localization					ovary(2)	2																		---	---	---	---
SNX1	6642	broad.mit.edu	37	15	64404959	64404959	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64404959delA	uc002amv.2	+						SNX1_uc010bgv.2_Intron|SNX1_uc010uio.1_Intron|SNX1_uc002amw.2_Intron|SNX1_uc002amx.2_Intron|SNX1_uc002amy.2_Intron|SNX1_uc010bgw.2_Intron	NM_003099	NP_003090			sorting nexin 1 isoform a						cell communication|early endosome to Golgi transport|endocytosis|intracellular protein transport	early endosome membrane|Golgi apparatus	phosphatidylinositol binding|protein binding|protein transporter activity				0																		---	---	---	---
TRIP4	9325	broad.mit.edu	37	15	64686385	64686385	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64686385delT	uc002anm.2	+							NM_016213	NP_057297			thyroid hormone receptor interactor 4						positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3																		---	---	---	---
OAZ2	4947	broad.mit.edu	37	15	64982422	64982422	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:64982422delA	uc002anp.2	-											Homo sapiens ornithine decarboxylase antizyme 2 (OAZ2) mRNA, complete cds.						polyamine metabolic process|regulation of cellular amino acid metabolic process	cytosol|nucleus	ornithine decarboxylase inhibitor activity|protein binding				0					L-Ornithine(DB00129)													---	---	---	---
PIF1	80119	broad.mit.edu	37	15	65110067	65110067	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65110067delA	uc002ant.2	-						PIF1_uc002anr.2_Intron|PIF1_uc002ans.2_Intron|PIF1_uc010uiq.1_Intron	NM_025049	NP_079325			DNA helicase homolog PIF1						negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding				0																		---	---	---	---
DPP8	54878	broad.mit.edu	37	15	65748828	65748828	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65748828delT	uc002aov.2	-						DPP8_uc002aow.2_Intron|DPP8_uc010uiv.1_Intron|DPP8_uc002aox.2_Intron|DPP8_uc002aoy.2_Intron|DPP8_uc002aoz.2_Intron|DPP8_uc010bhj.2_Intron|DPP8_uc002apa.2_Intron|DPP8_uc010bhi.2_Intron|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118			dipeptidyl peptidase 8 isoform 1						immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1																		---	---	---	---
PTPLAD1	51495	broad.mit.edu	37	15	65847385	65847387	+	Intron	DEL	AGA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65847385_65847387delAGA	uc002apc.2	+						PTPLAD1_uc002apb.1_Intron|PTPLAD1_uc010uiw.1_Intron	NM_016395	NP_057479			protein tyrosine phosphatase-like A domain						activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding				0																		---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65989151	65989151	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65989151delT	uc002aph.2	-						DENND4A_uc002api.2_Intron|DENND4A_uc002apj.3_Intron	NM_005848	NP_005839			DENN/MADD domain containing 4A isoform 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
MAP2K1	5604	broad.mit.edu	37	15	66781453	66781453	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66781453delA	uc010bhq.2	+						MAP2K1_uc010ujp.1_Intron	NM_002755	NP_002746			mitogen-activated protein kinase kinase 1						activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0														Cardiofaciocutaneous_syndrome				---	---	---	---
PIAS1	8554	broad.mit.edu	37	15	68468059	68468059	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68468059delA	uc002aqz.2	+	10	1350	c.1254delA	c.(1252-1254)TCAfs	p.S418fs	PIAS1_uc002ara.2_Frame_Shift_Del_p.S26fs	NM_016166	NP_057250	O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	418					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)	2																		---	---	---	---
UACA	55075	broad.mit.edu	37	15	70987451	70987451	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:70987451delA	uc002asr.2	-						UACA_uc010uke.1_Intron|UACA_uc002asq.2_Intron|UACA_uc010bin.1_Intron	NM_018003	NP_060473			uveal autoantigen with coiled-coil domains and							cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
LARP6	55323	broad.mit.edu	37	15	71128560	71128560	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:71128560delA	uc002ass.2	-							NM_018357	NP_060827			La ribonucleoprotein domain family, member 6						RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0																		---	---	---	---
LRRC49	54839	broad.mit.edu	37	15	71341735	71341735	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:71341735delT	uc002asw.2	+						LRRC49_uc002asu.2_Intron|LRRC49_uc002asx.2_Intron|LRRC49_uc010ukf.1_Intron|LRRC49_uc002asy.2_Intron|LRRC49_uc002asz.2_Intron	NM_017691	NP_060161			leucine rich repeat containing 49							cytoplasm|microtubule				ovary(1)	1																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72196394	72196394	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72196394delA	uc002atl.3	-						MYO9A_uc010biq.2_Intron|MYO9A_uc002atn.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
MYO9A	4649	broad.mit.edu	37	15	72270405	72270405	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72270405delA	uc002atl.3	-						MYO9A_uc010biq.2_Intron|MYO9A_uc002ato.2_Intron|MYO9A_uc002atn.1_Intron	NM_006901	NP_008832			myosin IXA						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
CELF6	60677	broad.mit.edu	37	15	72581468	72581468	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72581468delG	uc002auh.2	-						uc002aug.2_Intron|CELF6_uc002auk.3_Intron|CELF6_uc010biv.1_Intron|CELF6_uc010biw.2_Intron|CELF6_uc010ukl.1_Intron|CELF6_uc010ukm.1_Intron|CELF6_uc002aui.2_Intron|CELF6_uc002auj.2_Intron	NM_052840	NP_443072			bruno-like 6, RNA binding protein						mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	72899736	72899736	+	IGR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:72899736delG								MIR630 (20082 upstream) : GOLGA6B (47302 downstream)																																			---	---	---	---
HCN4	10021	broad.mit.edu	37	15	73615063	73615063	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73615063delC	uc002avp.2	-	8	4365	c.3371delG	c.(3370-3372)GGTfs	p.G1124fs		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	1124	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)														---	---	---	---
SIN3A	25942	broad.mit.edu	37	15	75706706	75706706	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:75706706delA	uc002bai.2	-						SIN3A_uc002baj.2_Intron|SIN3A_uc010uml.1_Intron	NM_015477	NP_056292			transcriptional co-repressor Sin3A						blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	76079339	76079340	+	5'Flank	DEL	AA	-	-	rs77222978		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:76079339_76079340delAA	uc002bbb.1	-						uc002bbc.1_5'Flank					DQ577530																														---	---	---	---
NRG4	145957	broad.mit.edu	37	15	76248176	76248176	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:76248176delT	uc002bbo.2	-						NRG4_uc010bkm.1_Intron|NRG4_uc002bbn.2_Intron|NRG4_uc010bkn.2_Intron|NRG4_uc010bko.2_Intron	NM_138573	NP_612640			neuregulin 4							extracellular region|integral to membrane|plasma membrane	growth factor activity				0																		---	---	---	---
ETFA	2108	broad.mit.edu	37	15	76577920	76577920	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:76577920delA	uc002bbt.2	-						ETFA_uc010bkq.1_Intron|ETFA_uc002bbu.1_Intron	NM_000126	NP_000117			electron transfer flavoprotein, alpha						respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity				0																		---	---	---	---
TBC1D2B	23102	broad.mit.edu	37	15	78310307	78310307	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78310307delA	uc002bcy.3	-						TBC1D2B_uc010bla.2_Intron|TBC1D2B_uc002bda.2_5'Flank	NM_144572	NP_653173			TBC1 domain family, member 2B isoform a							intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3																		---	---	---	---
IREB2	3658	broad.mit.edu	37	15	78758544	78758544	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78758544delT	uc002bdr.2	+						IREB2_uc010unb.1_Intron|IREB2_uc002bdq.2_Intron	NM_004136	NP_004127			iron-responsive element binding protein 2								4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)														---	---	---	---
KIAA1024	23251	broad.mit.edu	37	15	79750586	79750586	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:79750586delA	uc002bew.1	+	2	2172	c.2097delA	c.(2095-2097)TTAfs	p.L699fs	KIAA1024_uc010unk.1_Frame_Shift_Del_p.L699fs	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	699						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
MTHFS	10588	broad.mit.edu	37	15	80181816	80181817	+	Intron	DEL	AG	-	-	rs74835341		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:80181816_80181817delAG	uc002bex.3	-							NM_006441	NP_006432			5,10-methenyltetrahydrofolate synthetase						folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)														---	---	---	---
ARNT2	9915	broad.mit.edu	37	15	80873875	80873876	+	Intron	INS	-	CT	CT			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:80873875_80873876insCT	uc002bfr.2	+						ARNT2_uc010unm.1_Intron|ARNT2_uc002bfs.2_Intron	NM_014862	NP_055677			aryl hydrocarbon receptor nuclear translocator						central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)															---	---	---	---
GOLGA6L10	647042	broad.mit.edu	37	15	83014189	83014190	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83014189_83014190delAA	uc010unt.1	-						uc002bhl.2_Intron|uc002bhm.2_Intron|GOLGA6L10_uc010uny.1_Intron|GOLGA6L10_uc002bia.1_5'Flank					Homo sapiens cDNA FLJ40113 fis, clone TESTI2008621.												0																		---	---	---	---
ADAMTSL3	57188	broad.mit.edu	37	15	84442161	84442161	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:84442161delA	uc002bjz.3	+						ADAMTSL3_uc002bjy.1_Intron|ADAMTSL3_uc010bmt.1_Intron|ADAMTSL3_uc010bmu.1_Intron	NM_207517	NP_997400			ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)															---	---	---	---
PDE8A	5151	broad.mit.edu	37	15	85669755	85669755	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:85669755delT	uc002blh.2	+						PDE8A_uc002bli.2_Intron|PDE8A_uc010bnc.2_Intron|PDE8A_uc010bnd.2_Intron|PDE8A_uc002blj.2_Intron|PDE8A_uc002blk.2_Intron|PDE8A_uc002bll.2_Intron	NM_002605	NP_002596			phosphodiesterase 8A isoform 1						cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)															---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86087197	86087199	+	Intron	DEL	CTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86087197_86087199delCTT	uc002blv.1	+						AKAP13_uc002blt.1_Intron|AKAP13_uc002blu.1_Intron	NM_007200	NP_009131			A-kinase anchor protein 13 isoform 2						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
Unknown	0	broad.mit.edu	37	15	88301356	88301359	+	IGR	DEL	AAGA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:88301356_88301359delAAGA								NCRNA00052 (178439 upstream) : NTRK3 (118629 downstream)																																			---	---	---	---
ABHD2	11057	broad.mit.edu	37	15	89728843	89728844	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89728843_89728844delAA	uc002bnj.2	+						ABHD2_uc002bnk.2_Intron	NM_007011	NP_008942			alpha/beta hydrolase domain containing protein							integral to membrane	carboxylesterase activity			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)																	---	---	---	---
IQGAP1	8826	broad.mit.edu	37	15	91018049	91018049	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91018049delT	uc002bpl.1	+							NM_003870	NP_003861			IQ motif containing GTPase activating protein 1						energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)															---	---	---	---
SLCO3A1	28232	broad.mit.edu	37	15	92706427	92706428	+	3'UTR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:92706427_92706428insA	uc002bqx.2	+	10					SLCO3A1_uc002bqy.2_Intron	NM_013272	NP_037404			solute carrier organic anion transporter family,						sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)															---	---	---	---
MCTP2	55784	broad.mit.edu	37	15	94986209	94986210	+	Intron	INS	-	AC	AC			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:94986209_94986210insAC	uc002btj.2	+						MCTP2_uc010boj.2_Intron|MCTP2_uc010bok.2_Intron|MCTP2_uc002btl.2_Intron	NM_018349	NP_060819			multiple C2 domains, transmembrane 2 isoform 1						calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)															---	---	---	---
Unknown	0	broad.mit.edu	37	15	97170610	97170610	+	IGR	DEL	C	-	-	rs79611327		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:97170610delC								NR2F2 (287120 upstream) : SPATA8 (156069 downstream)																																			---	---	---	---
ALDH1A3	220	broad.mit.edu	37	15	101448785	101448785	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101448785delC	uc002bwn.3	+						ALDH1A3_uc010bpb.2_Intron|uc002bwo.1_Intron	NM_000693	NP_000684			aldehyde dehydrogenase 1A3						retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)													---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101593091	101593091	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101593091delG	uc002bwr.2	+						LRRK1_uc010usb.1_Intron|LRRK1_uc010usc.1_Intron|LRRK1_uc002bws.2_5'Flank	NM_024652	NP_078928			leucine-rich repeat kinase 1						small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
TM2D3	80213	broad.mit.edu	37	15	102185369	102185370	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:102185369_102185370delAA	uc002bxi.2	-						TM2D3_uc010usg.1_Intron|TM2D3_uc002bxh.2_Intron|TM2D3_uc002bxj.2_Intron|TM2D3_uc002bxk.2_Intron	NM_078474	NP_510883			TM2 domain containing 3 isoform a							integral to membrane				ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
AXIN1	8312	broad.mit.edu	37	16	347983	347983	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:347983delC	uc002cgp.1	-	6	1700	c.1523delG	c.(1522-1524)GGTfs	p.G508fs	AXIN1_uc002cgq.1_Frame_Shift_Del_p.G508fs	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	508	Interaction with RNF111.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)																---	---	---	---
AXIN1	8312	broad.mit.edu	37	16	396234	396234	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:396234delG	uc002cgp.1	-	2	969	c.792delC	c.(790-792)CCCfs	p.P264fs	AXIN1_uc002cgq.1_Frame_Shift_Del_p.P264fs	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	264	Interaction with TP53 (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)																---	---	---	---
CACNA1H	8912	broad.mit.edu	37	16	1250634	1250635	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1250634_1250635insC	uc002cks.2	+						CACNA1H_uc002ckt.2_Intron	NM_021098	NP_066921			calcium channel, voltage-dependent, T type,						aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)													---	---	---	---
RPL3L	6123	broad.mit.edu	37	16	2004575	2004575	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2004575delC	uc002cnh.2	-							NM_005061	NP_005052			ribosomal protein L3-like						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0																		---	---	---	---
DCI	1632	broad.mit.edu	37	16	2290224	2290224	+	Intron	DEL	A	-	-	rs26843	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2290224delA	uc002cpr.2	-						DCI_uc002cps.2_Intron	NM_001919	NP_001910			dodecenoyl-Coenzyme A delta isomerase precursor						fatty acid beta-oxidation	mitochondrial matrix	dodecenoyl-CoA delta-isomerase activity				0																		---	---	---	---
CREBBP	1387	broad.mit.edu	37	16	3823681	3823681	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3823681delA	uc002cvv.2	-						CREBBP_uc002cvw.2_Intron	NM_004380	NP_004371			CREB binding protein isoform a						cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)				T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				---	---	---	---
MGRN1	23295	broad.mit.edu	37	16	4718126	4718129	+	Intron	DEL	TTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4718126_4718129delTTTT	uc002cwz.2	+						MGRN1_uc002cxa.2_Intron|MGRN1_uc010btx.2_Intron|MGRN1_uc010btw.2_Intron|MGRN1_uc002cxb.2_Intron|MGRN1_uc010uxo.1_Intron|MGRN1_uc010uxp.1_Intron|MGRN1_uc010uxq.1_Intron	NM_001142290	NP_001135762			mahogunin, ring finger 1 isoform 3						endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2																		---	---	---	---
ALG1	56052	broad.mit.edu	37	16	5125391	5125391	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:5125391delC	uc002cym.2	+	4	434	c.393delC	c.(391-393)AACfs	p.N131fs	ALG1_uc002cyj.2_Frame_Shift_Del_p.N20fs|ALG1_uc002cyn.2_Frame_Shift_Del_p.N131fs|ALG1_uc010bue.2_Frame_Shift_Del_p.N20fs|ALG1_uc010uxy.1_Frame_Shift_Del_p.N20fs	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	131	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)																---	---	---	---
USP7	7874	broad.mit.edu	37	16	9010901	9010901	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:9010901delT	uc002czl.2	-	7	1032	c.833delA	c.(832-834)AAGfs	p.K278fs	USP7_uc010uyk.1_Frame_Shift_Del_p.K179fs|USP7_uc010uyj.1_Frame_Shift_Del_p.K179fs|USP7_uc002czk.2_Frame_Shift_Del_p.K262fs|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	278					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3																		---	---	---	---
FAM18A	780776	broad.mit.edu	37	16	10865686	10865686	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:10865686delT	uc010buo.1	-						FAM18A_uc010uyr.1_Intron|FAM18A_uc010uys.1_Intron|FAM18A_uc010uyt.1_Intron|FAM18A_uc010bun.2_Intron|FAM18A_uc010uyu.1_Intron|FAM18A_uc002dad.3_Intron|FAM18A_uc002daf.1_Intron|FAM18A_uc002dae.1_Intron	NM_001079512	NP_001072980			hypothetical protein LOC780776							integral to membrane					0																		---	---	---	---
CLEC16A	23274	broad.mit.edu	37	16	11051908	11051914	+	Intron	DEL	AAAAAAA	-	-	rs139179269		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11051908_11051914delAAAAAAA	uc002dao.2	+						CLEC16A_uc002dan.3_Intron	NM_015226	NP_056041			C-type lectin domain family 16, member A											ovary(1)|central_nervous_system(1)	2																		---	---	---	---
RSL1D1	26156	broad.mit.edu	37	16	11940252	11940252	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:11940252delA	uc002dbp.1	-						RSL1D1_uc010buv.1_Intron|RSL1D1_uc010uyw.1_Intron|RSL1D1_uc010buw.2_Intron	NM_015659	NP_056474			ribosomal L1 domain containing 1						regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0																		---	---	---	---
PARN	5073	broad.mit.edu	37	16	14693890	14693890	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14693890delA	uc010uzd.1	-						PARN_uc010uzc.1_Intron|PARN_uc010uze.1_Intron|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_Intron	NM_002582	NP_002573			poly(A)-specific ribonuclease (deadenylation						female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2																		---	---	---	---
NOMO1	23420	broad.mit.edu	37	16	14947960	14947960	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:14947960delA	uc002dcv.2	+							NM_014287	NP_055102			nodal modulator 1 precursor							integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1																		---	---	---	---
PDXDC1	23042	broad.mit.edu	37	16	15095527	15095528	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15095527_15095528insA	uc002dda.3	+						PDXDC1_uc010uzl.1_Intron|PDXDC1_uc010uzm.1_Intron|PDXDC1_uc010bvc.1_Intron|PDXDC1_uc002dcz.2_Intron|PDXDC1_uc002ddb.3_Intron|PDXDC1_uc010uzn.1_Intron|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842			pyridoxal-dependent decarboxylase domain						carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
RRN3	54700	broad.mit.edu	37	16	15164886	15164886	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15164886delA	uc002dde.2	-						PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Intron|RRN3_uc010uzq.1_Intron	NM_018427	NP_060897			RRN3 RNA polymerase I transcription factor						regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
RRN3	54700	broad.mit.edu	37	16	15170522	15170523	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15170522_15170523insA	uc002dde.2	-						PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Intron|RRN3_uc010uzq.1_Intron|RRN3_uc002ddf.1_Intron	NM_018427	NP_060897			RRN3 RNA polymerase I transcription factor						regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1																		---	---	---	---
MYH11	4629	broad.mit.edu	37	16	15820795	15820800	+	In_Frame_Del	DEL	CTTCTT	-	-	rs149241435	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15820795_15820800delCTTCTT	uc002ddy.2	-	28	3870_3875	c.3763_3768delAAGAAG	c.(3763-3768)AAGAAGdel	p.KK1255del	MYH11_uc002ddv.2_In_Frame_Del_p.KK1262del|MYH11_uc002ddw.2_In_Frame_Del_p.KK1255del|MYH11_uc002ddx.2_In_Frame_Del_p.KK1262del|MYH11_uc010bvg.2_In_Frame_Del_p.KK1087del|MYH11_uc010bvh.2_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1255_1256	Potential.		Missing (in AAT4).		axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15								T	CBFB	AML								---	---	---	---
C16orf63	123811	broad.mit.edu	37	16	15973654	15973654	+	Intron	DEL	G	-	-	rs8045082	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:15973654delG	uc002dec.1	-						C16orf63_uc002ded.1_Intron	NM_144600	NP_653201			hypothetical protein LOC123811						cilium assembly|microtubule anchoring	centriolar satellite|microtubule basal body|motile cilium	identical protein binding				0																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18883764	18883764	+	Intron	DEL	A	-	-	rs117332168	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18883764delA	uc002dfm.2	-						SMG1_uc010bwb.2_Intron	NM_015092	NP_055907			PI-3-kinase-related kinase SMG-1						DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
TMC7	79905	broad.mit.edu	37	16	19020932	19020932	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19020932delA	uc002dfq.2	+						TMC7_uc010vao.1_Intron|TMC7_uc002dfp.2_Intron|TMC7_uc010vap.1_Intron	NM_024847	NP_079123			transmembrane channel-like 7 isoform a							integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
TMC7	79905	broad.mit.edu	37	16	19049526	19049526	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19049526delT	uc002dfq.2	+						TMC7_uc010vao.1_Intron|TMC7_uc002dfp.2_Intron|TMC7_uc010vap.1_Intron	NM_024847	NP_079123			transmembrane channel-like 7 isoform a							integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
TMC7	79905	broad.mit.edu	37	16	19062983	19062983	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:19062983delT	uc002dfq.2	+						TMC7_uc002dfp.2_Intron|TMC7_uc010vap.1_Intron	NM_024847	NP_079123			transmembrane channel-like 7 isoform a							integral to membrane				skin(2)|ovary(1)	3																		---	---	---	---
ACSM5	54988	broad.mit.edu	37	16	20450998	20450998	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20450998delA	uc002dhe.2	+							NM_017888	NP_060358			acyl-CoA synthetase medium-chain family member 5						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2																		---	---	---	---
METTL9	51108	broad.mit.edu	37	16	21664118	21664118	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21664118delT	uc002dje.2	+						uc002diq.3_Intron|METTL9_uc002djf.2_Intron|IGSF6_uc002djg.1_5'Flank|IGSF6_uc010vbi.1_5'Flank	NM_016025	NP_057109			methyltransferase like 9 isoform 1											ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0759)														---	---	---	---
VWA3A	146177	broad.mit.edu	37	16	22155731	22155731	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22155731delT	uc010vbq.1	+						VWA3A_uc010bxd.2_Intron|VWA3A_uc002dkg.3_Intron|VWA3A_uc010bxe.1_5'Flank	NM_173615	NP_775886			von Willebrand factor A domain containing 3A							extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)														---	---	---	---
USP31	57478	broad.mit.edu	37	16	23098394	23098394	+	Intron	DEL	A	-	-	rs13339648		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23098394delA	uc002dll.2	-						USP31_uc010bxm.2_5'Flank	NM_020718	NP_065769			ubiquitin specific peptidase 31						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)														---	---	---	---
USP31	57478	broad.mit.edu	37	16	23117811	23117811	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23117811delA	uc002dll.2	-							NM_020718	NP_065769			ubiquitin specific peptidase 31						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)														---	---	---	---
PLK1	5347	broad.mit.edu	37	16	23691715	23691715	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:23691715delT	uc002dlz.1	+							NM_005030	NP_005021			polo-like kinase 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)														---	---	---	---
Unknown	0	broad.mit.edu	37	16	28549999	28549999	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28549999delA	uc010vct.1	-						NUPR1_uc002dqd.1_Intron|NUPR1_uc002dqe.1_Intron					RecName: Full=Nuclear pore complex-interacting protein-like 2; Flags: Precursor;																														---	---	---	---
INO80E	283899	broad.mit.edu	37	16	30016653	30016653	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30016653delC	uc002dvg.1	+	7	726	c.625delC	c.(625-627)CCCfs	p.P209fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvh.1_RNA|INO80E_uc002dvi.1_3'UTR|INO80E_uc002dvj.1_RNA|INO80E_uc002dvk.1_Frame_Shift_Del_p.P170fs	NM_173618	NP_775889	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	209	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				skin(1)	1																		---	---	---	---
ITGAL	3683	broad.mit.edu	37	16	30492667	30492676	+	Intron	DEL	AAAAAAAAAA	-	-	rs138296725		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30492667_30492676delAAAAAAAAAA	uc002dyi.3	+						ITGAL_uc010veu.1_Intron|ITGAL_uc002dyj.3_Intron|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200			integrin alpha L isoform a precursor						blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)													---	---	---	---
ITGAL	3683	broad.mit.edu	37	16	30518138	30518138	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30518138delC	uc002dyi.3	+	21	2645	c.2469delC	c.(2467-2469)TTCfs	p.F823fs	ITGAL_uc002dyj.3_Frame_Shift_Del_p.F739fs|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	823	Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)													---	---	---	---
PHKG2	5261	broad.mit.edu	37	16	30768112	30768112	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30768112delC	uc002dzk.1	+						PHKG2_uc002dzi.1_Intron|PHKG2_uc002dzj.1_Intron	NM_000294	NP_000285			phosphorylase kinase, gamma 2 (testis)						glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)															---	---	---	---
STX4	6810	broad.mit.edu	37	16	31050769	31050769	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31050769delT	uc002eal.2	+						STX4_uc002eak.2_Intron|STX4_uc002eam.2_Intron|uc002ean.1_5'Flank	NM_004604	NP_004595			syntaxin 4						intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0																		---	---	---	---
MYST1	84148	broad.mit.edu	37	16	31139392	31139392	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31139392delC	uc002eay.2	+	6	721	c.703delC	c.(703-705)CCCfs	p.P235fs	MYST1_uc002eax.2_Frame_Shift_Del_p.P235fs|MYST1_uc002eaz.2_Frame_Shift_Del_p.P77fs|MYST1_uc002eba.2_Frame_Shift_Del_p.P19fs|MYST1_uc002ebb.2_5'Flank	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	235					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	32198251	32198252	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:32198251_32198252delAA	uc010vfv.1	-											Homo sapiens cDNA FLJ60890 complete cds, moderately similar to HECT domain and RCC1-like domain-containing protein 2.																														---	---	---	---
Unknown	0	broad.mit.edu	37	16	34335946	34335946	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:34335946delT								MIR1826 (370354 upstream) : UBE2MP1 (67856 downstream)																																			---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47292700	47292700	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47292700delA	uc002eet.2	-						ITFG1_uc010vgg.1_Intron|ITFG1_uc010vgh.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
ITFG1	81533	broad.mit.edu	37	16	47347603	47347603	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:47347603delA	uc002eet.2	-						ITFG1_uc010vgg.1_Intron|ITFG1_uc010vgh.1_Intron	NM_030790	NP_110417			integrin alpha FG-GAP repeat containing 1							extracellular region|integral to membrane				ovary(1)|central_nervous_system(1)	2		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)																---	---	---	---
N4BP1	9683	broad.mit.edu	37	16	48585542	48585542	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48585542delA	uc002efp.2	-							NM_153029	NP_694574			Nedd4 binding protein 1						negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)																---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50128489	50128493	+	Intron	DEL	TTTTG	-	-	rs137967056	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50128489_50128493delTTTTG	uc002efw.2	+						HEATR3_uc002efx.2_Intron	NM_182922	NP_891552			HEAT repeat containing 3								binding			ovary(1)|skin(1)	2																		---	---	---	---
RBL2	5934	broad.mit.edu	37	16	53500814	53500814	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:53500814delT	uc002ehi.3	+						RBL2_uc010vgv.1_Intron|RBL2_uc002ehj.2_Intron|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602			retinoblastoma-like 2 (p130)						cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5																		---	---	---	---
IRX3	79191	broad.mit.edu	37	16	54319068	54319068	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:54319068delC	uc002eht.1	-	2	1141	c.725delG	c.(724-726)GGCfs	p.G242fs		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	242	Asp/Glu-rich (acidic).				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
LPCAT2	54947	broad.mit.edu	37	16	55579806	55579807	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55579806_55579807insT	uc002eie.3	+						LPCAT2_uc002eic.2_Intron	NM_017839	NP_060309			lysophosphatidylcholine acyltransferase 2						cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0																		---	---	---	---
CAPNS2	84290	broad.mit.edu	37	16	55600615	55600615	+	5'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:55600615delT	uc002eid.1	+	1					LPCAT2_uc002eie.3_Intron|LPCAT2_uc002eic.2_Intron	NM_032330	NP_115706			calpain small subunit 2							cytoplasm|plasma membrane	calcium ion binding				0																		---	---	---	---
NUP93	9688	broad.mit.edu	37	16	56872937	56872937	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:56872937delT	uc002eka.2	+	19	2213	c.2092delT	c.(2092-2094)TTTfs	p.F698fs	NUP93_uc002ekb.2_Frame_Shift_Del_p.F575fs|NUP93_uc010vhi.1_Frame_Shift_Del_p.F575fs	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	698					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2																		---	---	---	---
FAM192A	80011	broad.mit.edu	37	16	57188114	57188114	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57188114delT	uc010vhk.1	-	7					FAM192A_uc002ekz.3_3'UTR|FAM192A_uc002ekv.3_3'UTR|FAM192A_uc002ekw.3_3'UTR|FAM192A_uc002ekx.3_3'UTR|FAM192A_uc002eky.3_3'UTR	NM_024946	NP_079222			NEFA-interacting nuclear protein NIP30							nucleus					0																		---	---	---	---
RSPRY1	89970	broad.mit.edu	37	16	57246811	57246811	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57246811delA	uc002elb.2	+						RSPRY1_uc002elc.2_Intron|RSPRY1_uc002eld.2_Intron	NM_133368	NP_588609			ring finger and SPRY domain containing 1							extracellular region	zinc ion binding			ovary(1)	1																		---	---	---	---
CNGB1	1258	broad.mit.edu	37	16	57983030	57983031	+	Intron	DEL	GT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:57983030_57983031delGT	uc002emt.2	-						CNGB1_uc010cdh.2_Intron	NM_001297	NP_001288			cyclic nucleotide gated channel beta 1 isoform						sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4																		---	---	---	---
C16orf57	79650	broad.mit.edu	37	16	58048101	58048101	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58048101delT	uc002emz.2	+						C16orf57_uc010vib.1_Intron	NM_024598	NP_078874			hypothetical protein LOC79650												0																		---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58573529	58573530	+	Intron	DEL	AA	-	-	rs66742130		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58573529_58573530delAA	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc010vik.1_Intron	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58610315	58610315	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58610315delT	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc002enx.2_Intron|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
CNOT1	23019	broad.mit.edu	37	16	58622855	58622855	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:58622855delA	uc002env.2	-						CNOT1_uc002enw.2_Intron|CNOT1_uc002enu.3_Intron|CNOT1_uc002enx.2_Intron|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368			CCR4-NOT transcription complex, subunit 1						nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)														---	---	---	---
Unknown	0	broad.mit.edu	37	16	60058500	60058501	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:60058500_60058501insT								None (None upstream) : None (None downstream)																																			---	---	---	---
NAE1	8883	broad.mit.edu	37	16	66852580	66852581	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66852580_66852581delAA	uc002eqf.2	-						NAE1_uc002eqe.2_Intron|NAE1_uc002eqg.2_Intron|NAE1_uc010cdv.2_Intron|NAE1_uc010cdw.1_Intron	NM_003905	NP_003896			NEDD8 activating enzyme E1 subunit 1 isoform a						apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)													---	---	---	---
ELMO3	79767	broad.mit.edu	37	16	67233769	67233769	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67233769delC	uc002esa.2	+						ELMO3_uc002esb.2_Intron|ELMO3_uc002esc.2_Intron	NM_024712	NP_078988			engulfment and cell motility 3						apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)														---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67325776	67325777	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67325776_67325777delAA	uc002esu.2	-						KCTD19_uc002est.2_Intron|KCTD19_uc010vjj.1_Intron	NM_001100915	NP_001094385			potassium channel tetramerisation domain							voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
CTCF	10664	broad.mit.edu	37	16	67645338	67645339	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67645338_67645339insA	uc002etl.2	+	3	893_894	c.603_604insA	c.(601-606)GCCAAAfs	p.A201fs	CTCF_uc010cek.2_Intron	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	201_202					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)														---	---	---	---
EDC4	23644	broad.mit.edu	37	16	67919838	67919838	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67919838delT	uc002eut.1	+	1					NRN1L_uc002euu.2_Intron					Homo sapiens cDNA FLJ43830 fis, clone TESTI4004887, weakly  similar to Homo sapiens autoantigen (RCD-8).						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)														---	---	---	---
NFAT5	10725	broad.mit.edu	37	16	69710992	69710992	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:69710992delT	uc002exm.1	+						NFAT5_uc002exh.1_Intron|NFAT5_uc002exi.2_Intron|NFAT5_uc002exj.1_Intron|NFAT5_uc002exk.1_Intron|NFAT5_uc002exl.1_Intron|NFAT5_uc002exn.1_Intron	NM_006599	NP_006590			nuclear factor of activated T-cells 5 isoform c						excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
COG4	25839	broad.mit.edu	37	16	70515600	70515600	+	Intron	DEL	T	-	-	rs6416698	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70515600delT	uc002ezc.2	-						COG4_uc002eza.2_Intron|COG4_uc002ezb.2_Intron|COG4_uc010cfu.2_Intron|COG4_uc002ezd.2_Intron|COG4_uc002eze.2_Intron	NM_015386	NP_056201			component of oligomeric golgi complex 4						Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)																---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71784038	71784038	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71784038delA	uc010cgg.2	-						AP1G1_uc002fba.2_Intron|AP1G1_uc002fbb.2_Intron|AP1G1_uc002faz.2_5'Flank	NM_001128	NP_001119			adaptor-related protein complex 1, gamma 1						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71795578	71795578	+	Intron	DEL	A	-	-	rs142639197	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71795578delA	uc010cgg.2	-						AP1G1_uc002fba.2_Intron|AP1G1_uc002fbb.2_Intron|AP1G1_uc010vmg.1_Intron	NM_001128	NP_001119			adaptor-related protein complex 1, gamma 1						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
AP1G1	164	broad.mit.edu	37	16	71803440	71803440	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71803440delA	uc010cgg.2	-						AP1G1_uc002fba.2_Intron|AP1G1_uc002fbb.2_Intron|AP1G1_uc010vmg.1_Intron|AP1G1_uc010vmh.1_Intron	NM_001128	NP_001119			adaptor-related protein complex 1, gamma 1						endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)																---	---	---	---
ADAT1	23536	broad.mit.edu	37	16	75634035	75634035	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75634035delA	uc002feo.1	-	11					ADAT1_uc002fep.1_3'UTR	NM_012091	NP_036223			adenosine deaminase, tRNA-specific 1						tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	76268905	76268905	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:76268905delT								TERF2IP (577577 upstream) : CNTNAP4 (42271 downstream)																																			---	---	---	---
CENPN	55839	broad.mit.edu	37	16	81058306	81058306	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81058306delT	uc002ffx.2	+						CENPN_uc010vnl.1_Intron|CENPN_uc010vnm.1_Intron|CENPN_uc002ffy.3_Intron	NM_001100624	NP_001094094			centromere protein N isoform 2						CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0																		---	---	---	---
HSBP1	3281	broad.mit.edu	37	16	83843068	83843073	+	Intron	DEL	TTTTTT	-	-	rs149539074		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:83843068_83843073delTTTTTT	uc002fgy.1	+							NM_001537	NP_001528			heat shock factor binding protein 1						negative regulation of transcription from RNA polymerase II promoter	nucleus	transcription corepressor activity				0		all_cancers(2;0.00573)|all_epithelial(2;0.0309)		BRCA - Breast invasive adenocarcinoma(80;0.0404)														---	---	---	---
USP10	9100	broad.mit.edu	37	16	84806174	84806175	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84806174_84806175insA	uc002fii.2	+	12	2168_2169	c.2026_2027insA	c.(2026-2028)GAAfs	p.E676fs	USP10_uc010voe.1_Frame_Shift_Ins_p.E680fs|USP10_uc010vof.1_Frame_Shift_Ins_p.E238fs|USP10_uc002fij.2_Frame_Shift_Ins_p.E202fs	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	676					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0																		---	---	---	---
ZFPM1	161882	broad.mit.edu	37	16	88593209	88593211	+	Intron	DEL	CCT	-	-	rs111670467	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88593209_88593211delCCT	uc002fkv.2	+							NM_153813	NP_722520			zinc finger protein, multitype 1						blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)														---	---	---	---
ZFPM1	161882	broad.mit.edu	37	16	88601440	88601440	+	3'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88601440delG	uc002fkv.2	+	10						NM_153813	NP_722520			zinc finger protein, multitype 1						blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)														---	---	---	---
Unknown	0	broad.mit.edu	37	16	88620072	88620073	+	IGR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:88620072_88620073delAA								ZFPM1 (18499 upstream) : ZC3H18 (16716 downstream)																																			---	---	---	---
FANCA	2175	broad.mit.edu	37	16	89809062	89809069	+	Intron	DEL	AAAAAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89809062_89809069delAAAAAAAA	uc002fou.1	-						FANCA_uc010vpn.1_Intron|FANCA_uc010vpo.1_Intron	NM_000135	NP_000126			Fanconi anemia, complementation group A isoform						DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)				D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
RPH3AL	9501	broad.mit.edu	37	17	69318	69322	+	Intron	DEL	TTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:69318_69322delTTTTT	uc002frd.1	-						RPH3AL_uc010vpy.1_Intron|RPH3AL_uc002fre.1_Intron|RPH3AL_uc002frf.1_Intron|RPH3AL_uc010cjl.1_Intron	NM_006987	NP_008918			rabphilin 3A-like (without C2 domains)						exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)														---	---	---	---
VPS53	55275	broad.mit.edu	37	17	527002	527002	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:527002delA	uc002frn.2	-						VPS53_uc002frk.2_Intron|VPS53_uc010cjo.1_Intron|VPS53_uc002frl.2_Intron|VPS53_uc002frm.2_Intron|VPS53_uc002fro.2_Intron|VPS53_uc010cjp.1_Intron	NM_018289	NP_060759			vacuolar protein sorting 53 isoform 2						protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)														---	---	---	---
RNMTL1	55178	broad.mit.edu	37	17	691505	691505	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:691505delA	uc002frw.2	+							NM_018146	NP_060616			RNA methyltransferase like 1						RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)														---	---	---	---
MYO1C	4641	broad.mit.edu	37	17	1383015	1383015	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1383015delG	uc002fsp.2	-						MYO1C_uc002fsn.2_Intron|MYO1C_uc002fso.2_Intron|MYO1C_uc010vqj.1_Intron|MYO1C_uc010vqk.1_Intron	NM_001080779	NP_001074248			myosin IC isoform a						mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
WDR81	124997	broad.mit.edu	37	17	1638935	1638935	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1638935delC	uc002fti.2	+	8	1829	c.1568delC	c.(1567-1569)GCCfs	p.A523fs	WDR81_uc002fth.2_Frame_Shift_Del_p.A699fs|WDR81_uc010vqp.1_Frame_Shift_Del_p.A547fs|WDR81_uc002ftj.2_Frame_Shift_Del_p.A1750fs|WDR81_uc010vqq.1_Frame_Shift_Del_p.A381fs	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	523										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
TSR1	55720	broad.mit.edu	37	17	2227356	2227356	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2227356delA	uc002fuj.2	-	15					SRR_uc002fue.1_3'UTR|SRR_uc002fui.1_3'UTR	NM_018128	NP_060598			TSR1, 20S rRNA accumulation						ribosome assembly	nucleolus	protein binding			ovary(1)	1																		---	---	---	---
PAFAH1B1	5048	broad.mit.edu	37	17	2568632	2568632	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2568632delT	uc002fuw.3	+						PAFAH1B1_uc010ckb.1_Intron	NM_000430	NP_000421			platelet-activating factor acetylhydrolase,						acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1																		---	---	---	---
CTNS	1497	broad.mit.edu	37	17	3559746	3559746	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3559746delC	uc002fwb.2	+						CTNS_uc002fwa.2_Intron|CTNS_uc010ckj.2_Intron|CTNS_uc010vrv.1_Intron|CTNS_uc010vrw.1_Intron	NM_004937	NP_004928			cystinosin isoform 2						ATP metabolic process|brain development|cognition|glutathione metabolic process	integral to membrane|late endosome|lysosomal membrane	L-cystine transmembrane transporter activity				0				COAD - Colon adenocarcinoma(5;0.0829)	L-Cystine(DB00138)													---	---	---	---
C17orf85	55421	broad.mit.edu	37	17	3725406	3725406	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3725406delT	uc010ckl.1	-						C17orf85_uc002fwr.2_Intron|C17orf85_uc002fwq.2_Intron	NM_001114118	NP_001107590			ELG protein isoform a								nucleotide binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)														---	---	---	---
P2RX1	5023	broad.mit.edu	37	17	3807163	3807164	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3807163_3807164insC	uc002fww.2	-							NM_002558	NP_002549			purinergic receptor P2X1						platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)														---	---	---	---
PELP1	27043	broad.mit.edu	37	17	4575894	4575894	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4575894delG	uc002fyi.3	-	16	2618	c.2392delC	c.(2392-2394)CTGfs	p.L798fs	PELP1_uc010vsf.1_Frame_Shift_Del_p.L651fs	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	798	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
GP1BA	2811	broad.mit.edu	37	17	4835838	4835838	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4835838delG	uc010vsq.1	+							NM_000173	NP_000164			platelet glycoprotein Ib alpha polypeptide												0																		---	---	---	---
MIS12	79003	broad.mit.edu	37	17	5392101	5392101	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5392101delT	uc002gcd.2	+						DERL2_uc002gcc.1_5'Flank|MIS12_uc002gce.2_Intron	NM_024039	NP_076944			MIS12 homolog						cell division|chromosome segregation|kinetochore assembly|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding				0																		---	---	---	---
MED31	51003	broad.mit.edu	37	17	6547714	6547714	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:6547714delT	uc002gdg.3	-	4					MED31_uc002gdh.3_RNA|TXNDC17_uc002gdf.3_3'UTR	NM_016060	NP_057144			mediator of RNA polymerase II transcription,						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding				0																		---	---	---	---
PHF23	79142	broad.mit.edu	37	17	7139763	7139764	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7139763_7139764insG	uc002gfa.2	-	4	709_710	c.482_483insC	c.(481-483)CCTfs	p.P161fs	DVL2_uc002gez.1_5'Flank|DVL2_uc010vtr.1_5'Flank|DVL2_uc010clz.1_5'Flank|PHF23_uc010vtt.1_Frame_Shift_Ins_p.P94fs|PHF23_uc010cma.2_Frame_Shift_Ins_p.P31fs	NM_024297	NP_077273	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	161							zinc ion binding				0																		---	---	---	---
ATP1B2	482	broad.mit.edu	37	17	7557763	7557763	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7557763delT	uc002gif.1	+							NM_001678	NP_001669			Na+/K+ -ATPase beta 2 subunit						ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)														---	---	---	---
CHD3	1107	broad.mit.edu	37	17	7796827	7796827	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7796827delC	uc002gje.2	+	5	883	c.733delC	c.(733-735)CCCfs	p.P245fs	CHD3_uc002gjd.2_Frame_Shift_Del_p.P304fs|CHD3_uc002gjf.2_Frame_Shift_Del_p.P245fs|CHD3_uc002gjg.1_Frame_Shift_Del_p.P77fs	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	245	Poly-Pro.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)																---	---	---	---
SPDYE4	388333	broad.mit.edu	37	17	8658750	8658750	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8658750delA	uc010cnz.1	-							NM_001128076	NP_001121548			speedy homolog E4												0																		---	---	---	---
PIK3R6	146850	broad.mit.edu	37	17	8731357	8731357	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8731357delG	uc002glq.1	-						PIK3R6_uc002glr.1_Intron|PIK3R6_uc002gls.1_Intron	NM_001010855	NP_001010855			phosphoinositide-3-kinase, regulatory subunit 6						platelet activation	cytosol					0																		---	---	---	---
STX8	9482	broad.mit.edu	37	17	9282137	9282137	+	Intron	DEL	A	-	-	rs139246965	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9282137delA	uc002glx.2	-							NM_004853	NP_004844			syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1																		---	---	---	---
WDR16	146845	broad.mit.edu	37	17	9490186	9490186	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9490186delT	uc002gly.2	+						WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Intron	NM_145054	NP_659491			WD40-repeat protein upregulated in HCC isoform							cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4																		---	---	---	---
MYH8	4626	broad.mit.edu	37	17	10305158	10305159	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10305158_10305159insT	uc002gmm.2	-						uc002gml.1_Intron	NM_002472	NP_002463			myosin, heavy chain 8, skeletal muscle,						muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11														Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				---	---	---	---
MYH4	4622	broad.mit.edu	37	17	10355897	10355897	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10355897delT	uc002gmn.2	-						uc002gml.1_Intron	NM_017533	NP_060003			myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13																		---	---	---	---
MYH2	4620	broad.mit.edu	37	17	10439795	10439796	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:10439795_10439796insA	uc010coi.2	-						uc002gml.1_Intron|MYH2_uc002gmp.3_Intron|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582			myosin heavy chain IIa						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14																		---	---	---	---
DNAH9	1770	broad.mit.edu	37	17	11532984	11532984	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:11532984delT	uc002gne.2	+							NM_001372	NP_001363			dynein, axonemal, heavy chain 9 isoform 2						cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)														---	---	---	---
MAP2K4	6416	broad.mit.edu	37	17	12011155	12011155	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12011155delT	uc002gnj.2	+	5	631	c.562delT	c.(562-564)TTTfs	p.F188fs	MAP2K4_uc002gnk.2_Frame_Shift_Del_p.F199fs|MAP2K4_uc010vvi.1_Frame_Shift_Del_p.F70fs|MAP2K4_uc010vvj.1_Frame_Shift_Del_p.F60fs	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	188	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)				D|Mis|N		pancreatic|breast|colorectal								---	---	---	---
MAP2K4	6416	broad.mit.edu	37	17	12011336	12011336	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12011336delA	uc002gnj.2	+						MAP2K4_uc002gnk.2_Intron|MAP2K4_uc010vvi.1_Intron|MAP2K4_uc010vvj.1_Intron	NM_003010	NP_003001			mitogen-activated protein kinase kinase 4						cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)				D|Mis|N		pancreatic|breast|colorectal								---	---	---	---
MYOCD	93649	broad.mit.edu	37	17	12642606	12642606	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:12642606delC	uc002gnn.2	+	7	977	c.678delC	c.(676-678)GGCfs	p.G226fs	MYOCD_uc002gno.2_Frame_Shift_Del_p.G226fs|MYOCD_uc002gnp.1_Frame_Shift_Del_p.G130fs	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	226					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)														---	---	---	---
FAM18B2	201158	broad.mit.edu	37	17	15469677	15469678	+	5'Flank	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15469677_15469678insA	uc002goq.2	-						CDRT4_uc010vvw.1_5'Flank|FAM18B2_uc010vvx.1_5'Flank|FAM18B2_uc010cor.2_5'Flank	NM_145301	NP_660344			hypothetical protein LOC201158 isoform 1							integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)														---	---	---	---
LRRC48	83450	broad.mit.edu	37	17	17914253	17914254	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17914253_17914254insT	uc010vxd.1	+						LRRC48_uc002gsb.2_Intron	NM_001130090	NP_001123562			leucine rich repeat containing 48 isoform a							cytoplasm				pancreas(1)	1	all_neural(463;0.228)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	18304008	18304008	+	5'Flank	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18304008delG	uc010vxw.1	-						uc002gto.2_5'Flank					DQ589132																														---	---	---	---
LOC339240	339240	broad.mit.edu	37	17	18320862	18320862	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18320862delA	uc010vxy.1	+											Homo sapiens keratin pseudogene, mRNA (cDNA clone IMAGE:5270734).												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	17	18988562	18988562	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18988562delT								GRAP (38226 upstream) : GRAPL (42220 downstream)																																			---	---	---	---
ULK2	9706	broad.mit.edu	37	17	19719998	19719998	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:19719998delA	uc002gwm.3	-						ULK2_uc002gwn.2_Intron	NM_001142610	NP_001136082			unc-51-like kinase 2						signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	21408420	21408420	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21408420delA								KCNJ12 (85241 upstream) : C17orf51 (23152 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	17	25991720	25991720	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:25991720delA								LGALS9 (15135 upstream) : NOS2 (92073 downstream)																																			---	---	---	---
NLK	51701	broad.mit.edu	37	17	26459626	26459626	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26459626delT	uc010crj.2	+						NLK_uc010cri.1_Intron	NM_016231	NP_057315			nemo like kinase						intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
NLK	51701	broad.mit.edu	37	17	26512302	26512303	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26512302_26512303delTT	uc010crj.2	+						NLK_uc010cri.1_Intron	NM_016231	NP_057315			nemo like kinase						intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)														---	---	---	---
KIAA0100	9703	broad.mit.edu	37	17	26947118	26947118	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26947118delG	uc002hbu.2	-						KIAA0100_uc002hbt.2_Intron	NM_014680	NP_055495			hypothetical protein LOC9703 precursor							extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
SEZ6	124925	broad.mit.edu	37	17	27296913	27296914	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27296913_27296914insC	uc002hdp.2	-	4	1109_1110	c.915_916insG	c.(913-918)GGGCCTfs	p.G305fs	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Frame_Shift_Ins_p.G305fs|SEZ6_uc002hdq.1_Frame_Shift_Ins_p.G180fs|SEZ6_uc010crz.1_Frame_Shift_Ins_p.G305fs	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	305_306	Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)															---	---	---	---
Unknown	0	broad.mit.edu	37	17	27531084	27531085	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27531084_27531085insT								MYO18A (23677 upstream) : CRYBA1 (42790 downstream)																																			---	---	---	---
BLMH	642	broad.mit.edu	37	17	28613992	28613993	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28613992_28613993insA	uc002hez.1	-						BLMH_uc010wbn.1_Intron	NM_000386	NP_000377			bleomycin hydrolase						proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1																		---	---	---	---
SUZ12P	440423	broad.mit.edu	37	17	29086616	29086616	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29086616delA	uc002hfn.1	+						SUZ12P_uc002hfo.2_Intron|SUZ12P_uc002hfq.2_Intron					Homo sapiens cDNA clone IMAGE:5299523, containing frame-shift errors.												0																		---	---	---	---
SUZ12P	440423	broad.mit.edu	37	17	29096087	29096087	+	RNA	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29096087delT	uc002hfn.1	+	6		c.1599delT			SUZ12P_uc002hfo.2_Intron|SUZ12P_uc002hfq.2_Intron					Homo sapiens cDNA clone IMAGE:5299523, containing frame-shift errors.												0																		---	---	---	---
NF1	4763	broad.mit.edu	37	17	29553477	29553478	+	Frame_Shift_Ins	INS	-	C	C	rs145092683		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:29553477_29553478insC	uc002hgg.2	+	18	2359_2360	c.2026_2027insC	c.(2026-2028)ACCfs	p.T676fs	NF1_uc002hgh.2_Frame_Shift_Ins_p.T676fs|NF1_uc010csn.1_Frame_Shift_Ins_p.T536fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	676					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.P678fs*10(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)				D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	---	---	---
UTP6	55813	broad.mit.edu	37	17	30194974	30194975	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30194974_30194975insA	uc002hgr.2	-						UTP6_uc002hgq.2_Intron|UTP6_uc010cst.2_Intron	NM_018428	NP_060898			hepatocellular carcinoma-associated antigen 66						rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)																---	---	---	---
UTP6	55813	broad.mit.edu	37	17	30200273	30200273	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30200273delA	uc002hgr.2	-						UTP6_uc002hgq.2_Intron|UTP6_uc010cst.2_Intron	NM_018428	NP_060898			hepatocellular carcinoma-associated antigen 66						rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)																---	---	---	---
PSMD11	5717	broad.mit.edu	37	17	30773801	30773801	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:30773801delT	uc010cta.1	+						PSMD11_uc010wbz.1_Intron|PSMD11_uc002hhm.2_Intron	NM_002815	NP_002806			proteasome 26S non-ATPase subunit 11						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)															---	---	---	---
CCT6B	10693	broad.mit.edu	37	17	33267439	33267439	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33267439delT	uc002hig.2	-						CCT6B_uc010ctg.2_Intron|CCT6B_uc010wcc.1_Intron	NM_006584	NP_006575			chaperonin containing TCP1, subunit 6B						chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)																---	---	---	---
ACACA	31	broad.mit.edu	37	17	35545510	35545510	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35545510delA	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuy.2_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35548923	35548923	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35548923delT	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuy.2_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
ACACA	31	broad.mit.edu	37	17	35583096	35583096	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35583096delA	uc002hnm.2	-						ACACA_uc002hnk.2_Intron|ACACA_uc002hnl.2_Intron|ACACA_uc002hnn.2_Intron|ACACA_uc002hno.2_Intron|ACACA_uc010cuz.2_Intron	NM_198836	NP_942133			acetyl-Coenzyme A carboxylase alpha isoform 2						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)													---	---	---	---
DDX52	11056	broad.mit.edu	37	17	35985898	35985899	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:35985898_35985899delAA	uc002hoi.1	-						DDX52_uc002hoh.1_Intron	NM_007010	NP_008941			ATP-dependent RNA helicase ROK1 isoform a							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)																---	---	---	---
MED1	5469	broad.mit.edu	37	17	37596378	37596379	+	Intron	INS	-	AAGG	AAGG			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37596378_37596379insAAGG	uc002hrv.3	-						MED1_uc010wee.1_Intron|MED1_uc002hru.2_Intron	NM_004774	NP_004765			mediator complex subunit 1						androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)											HNSCC(31;0.082)			---	---	---	---
RARA	5914	broad.mit.edu	37	17	38499151	38499151	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38499151delG	uc002huk.1	+						RARA_uc002hul.3_Intron|RARA_uc010wfe.1_Intron|RARA_uc002hun.1_Intron	NM_000964	NP_000955			retinoic acid receptor, alpha isoform 1						apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)			T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								---	---	---	---
SMARCE1	6605	broad.mit.edu	37	17	38798596	38798596	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38798596delA	uc002hux.2	-						SMARCE1_uc010wff.1_Intron|SMARCE1_uc010wfg.1_Intron|SMARCE1_uc002huy.2_Intron|SMARCE1_uc010wfh.1_Intron|SMARCE1_uc010wfi.1_Intron|SMARCE1_uc002huz.1_Intron|SMARCE1_uc010wfj.1_Intron|SMARCE1_uc002hva.2_3'UTR	NM_003079	NP_003070			SWI/SNF-related matrix-associated						chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)																---	---	---	---
KRT24	192666	broad.mit.edu	37	17	38854446	38854446	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:38854446delT	uc002hvd.2	-	8						NM_019016	NP_061889			keratin 24							cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.00526)																---	---	---	---
KRT23	25984	broad.mit.edu	37	17	39079110	39079111	+	3'UTR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39079110_39079111insA	uc002hvm.1	-	9					KRT23_uc010wfl.1_3'UTR|KRT23_uc010cxf.1_3'UTR	NM_015515	NP_056330			keratin 23							intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	39369047	39369047	+	IGR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39369047delC								KRTAP4-1 (5921 upstream) : KRTAP9-2 (13853 downstream)																																			---	---	---	---
HAP1	9001	broad.mit.edu	37	17	39888235	39888237	+	In_Frame_Del	DEL	CTT	-	-	rs150945451	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39888235_39888237delCTT	uc002hxm.1	-	4	860_862	c.848_850delAAG	c.(847-852)GAAGCA>GCA	p.E283del	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_In_Frame_Del_p.E283del|HAP1_uc002hxo.1_In_Frame_Del_p.E291del|HAP1_uc002hxp.1_In_Frame_Del_p.E283del	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	283	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)															---	---	---	---
TTC25	83538	broad.mit.edu	37	17	40104749	40104749	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40104749delT	uc002hyj.3	+						TTC25_uc010cxt.2_Intron	NM_031421	NP_113609			tetratricopeptide repeat domain 25							cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)																---	---	---	---
KCNH4	23415	broad.mit.edu	37	17	40328370	40328370	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40328370delG	uc002hzb.2	-							NM_012285	NP_036417			potassium voltage-gated channel, subfamily H,						regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)														---	---	---	---
MLX	6945	broad.mit.edu	37	17	40720380	40720380	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40720380delA	uc002iag.2	+						MLX_uc002iaf.2_Intron|MLX_uc002iah.2_Intron	NM_170607	NP_733752			transcription factor-like protein 4 isoform						energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)														---	---	---	---
FAM134C	162427	broad.mit.edu	37	17	40734988	40734988	+	Intron	DEL	T	-	-	rs35747013		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40734988delT	uc002ial.2	-						FAM134C_uc010wgq.1_Intron|FAM134C_uc002iam.1_Intron|FAM134C_uc010cyk.1_Intron	NM_178126	NP_835227			hypothetical protein LOC162427							integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)														---	---	---	---
CNTNAP1	8506	broad.mit.edu	37	17	40851054	40851054	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40851054delC	uc002iay.2	+	24					CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623			contactin associated protein 1 precursor						axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)														---	---	---	---
VPS25	84313	broad.mit.edu	37	17	40925964	40925965	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40925964_40925965insC	uc002ibi.2	+							NM_032353	NP_115729			vacuolar protein sorting 25						cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endosome membrane|nucleoplasm					0		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)														---	---	---	---
CNTD1	124817	broad.mit.edu	37	17	40961345	40961346	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40961345_40961346insT	uc002ibm.3	+						CNTD1_uc010wha.1_Intron	NM_173478	NP_775749			cyclin N-terminal domain containing 1											central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)														---	---	---	---
VAT1	10493	broad.mit.edu	37	17	41168595	41168595	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41168595delC	uc002icm.1	-						VAT1_uc010cyw.1_Intron|VAT1_uc010whk.1_Intron	NM_006373	NP_006364			vesicle amine transport protein 1							cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)														---	---	---	---
BRCA1	672	broad.mit.edu	37	17	41297124	41297124	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41297124delA	uc010whp.1	-						NBR2_uc002idh.2_Intron	NM_007298	NP_009229			breast cancer 1, early onset isoform 4						androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)				D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			---	---	---	---
DHX8	1659	broad.mit.edu	37	17	41570774	41570774	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41570774delT	uc002idu.1	+						DHX8_uc010wif.1_Intron|DHX8_uc010wig.1_Intron	NM_004941	NP_004932			DEAH (Asp-Glu-Ala-His) box polypeptide 8							catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)														---	---	---	---
C17orf53	78995	broad.mit.edu	37	17	42225763	42225763	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42225763delA	uc002ifi.1	+	3	777	c.592delA	c.(592-594)AAAfs	p.K198fs	C17orf53_uc010czq.1_Frame_Shift_Del_p.K198fs|C17orf53_uc002ifj.1_Frame_Shift_Del_p.K198fs|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	198											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)														---	---	---	---
UBTF	7343	broad.mit.edu	37	17	42284469	42284471	+	3'UTR	DEL	TTT	-	-	rs75104069		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42284469_42284471delTTT	uc002igb.2	-	20					UBTF_uc002igc.2_3'UTR|UBTF_uc010czs.2_3'UTR|UBTF_uc002igd.2_3'UTR|UBTF_uc010czt.2_3'UTR	NM_014233	NP_055048			upstream binding transcription factor, RNA						positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)														---	---	---	---
GPATCH8	23131	broad.mit.edu	37	17	42483339	42483339	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42483339delT	uc002igw.1	-	7	637	c.573delA	c.(571-573)AAAfs	p.K191fs	GPATCH8_uc002igv.1_Frame_Shift_Del_p.K113fs|GPATCH8_uc010wiz.1_Frame_Shift_Del_p.K113fs	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	191						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)														---	---	---	---
CCDC43	124808	broad.mit.edu	37	17	42756539	42756539	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42756539delA	uc002ihc.2	-						CCDC43_uc010czw.1_Intron	NM_144609	NP_653210			coiled-coil domain containing 43 isoform 1												0		Prostate(33;0.0322)																---	---	---	---
Unknown	0	broad.mit.edu	37	17	43675963	43675964	+	IGR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43675963_43675964delAA								LRRC37A4 (80447 upstream) : LOC644172 (1527 downstream)																																			---	---	---	---
KIAA1267	284058	broad.mit.edu	37	17	44109601	44109601	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44109601delG	uc002ikb.2	-	13	2987	c.2902delC	c.(2902-2904)CAGfs	p.Q968fs	KIAA1267_uc002ikc.2_Frame_Shift_Del_p.Q968fs|KIAA1267_uc002ikd.2_Frame_Shift_Del_p.Q968fs|KIAA1267_uc010dav.2_Frame_Shift_Del_p.Q967fs|KIAA1267_uc010wkb.1_Frame_Shift_Del_p.Q299fs|KIAA1267_uc010wkc.1_Frame_Shift_Del_p.Q236fs	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	968						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)																---	---	---	---
WNT3	7473	broad.mit.edu	37	17	44851007	44851007	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:44851007delC	uc002ikv.2	-							NM_030753	NP_110380			wingless-type MMTV integration site family,						canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)															---	---	---	---
NPEPPS	9520	broad.mit.edu	37	17	45691166	45691166	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45691166delA	uc002ilr.3	+						NPEPPS_uc010wkt.1_Intron|NPEPPS_uc010wku.1_Intron|NPEPPS_uc010wkv.1_Intron|NPEPPS_uc002ils.1_Intron	NM_006310	NP_006301			aminopeptidase puromycin sensitive						proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0																		---	---	---	---
OSBPL7	114881	broad.mit.edu	37	17	45894763	45894763	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:45894763delT	uc002ilx.1	-						OSBPL7_uc002ilw.1_5'Flank	NM_145798	NP_665741			oxysterol-binding protein-like protein 7						lipid transport		lipid binding				0																		---	---	---	---
SLC35B1	10237	broad.mit.edu	37	17	47783742	47783743	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47783742_47783743insG	uc002iph.1	-						SLC35B1_uc002ipi.1_Intron|SLC35B1_uc002ipj.1_Intron|SLC35B1_uc010wly.1_Intron	NM_005827	NP_005818			solute carrier family 35, member B1							endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0																		---	---	---	---
XYLT2	64132	broad.mit.edu	37	17	48433967	48433967	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48433967delC	uc002iqo.2	+	8	1687	c.1578delC	c.(1576-1578)TACfs	p.Y526fs	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	526	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)																	---	---	---	---
MBTD1	54799	broad.mit.edu	37	17	49281117	49281117	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49281117delA	uc002itr.3	-						MBTD1_uc002itp.3_Intron|MBTD1_uc002itq.3_Intron	NM_017643	NP_060113			mbt domain containing 1						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)															---	---	---	---
ANKFN1	162282	broad.mit.edu	37	17	54305178	54305178	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54305178delT	uc002iun.1	+						uc002iuo.2_5'Flank	NM_153228	NP_694960			ankyrin-repeat and fibronectin type III domain											large_intestine(1)|ovary(1)	2																		---	---	---	---
ANKFN1	162282	broad.mit.edu	37	17	54555176	54555177	+	Intron	DEL	TT	-	-	rs113151852		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:54555176_54555177delTT	uc002iun.1	+							NM_153228	NP_694960			ankyrin-repeat and fibronectin type III domain											large_intestine(1)|ovary(1)	2																		---	---	---	---
MSI2	124540	broad.mit.edu	37	17	55334367	55334367	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:55334367delC	uc002iuz.1	+						MSI2_uc010wnm.1_Intron|MSI2_uc002iva.2_5'Flank	NM_138962	NP_620412			musashi 2 isoform a							cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)				T	HOXA9	CML								---	---	---	---
EPX	8288	broad.mit.edu	37	17	56272511	56272511	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56272511delC	uc002ivq.2	+	6	867	c.781delC	c.(781-783)CCCfs	p.P261fs		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	261					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2																		---	---	---	---
EPX	8288	broad.mit.edu	37	17	56280726	56280726	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56280726delA	uc002ivq.2	+							NM_000502	NP_000493			eosinophil peroxidase preproprotein						hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2																		---	---	---	---
HSF5	124535	broad.mit.edu	37	17	56544095	56544095	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56544095delT	uc002iwi.1	-							NM_001080439	NP_001073908			heat shock transcription factor family member 5							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
PRR11	55771	broad.mit.edu	37	17	57247171	57247171	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57247171delA	uc002ixf.1	+	2	137	c.58delA	c.(58-60)AAAfs	p.K20fs	PRR11_uc002ixg.1_RNA	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	proline rich 11	20										ovary(2)	2	Medulloblastoma(34;0.0922)|all_neural(34;0.101)																	---	---	---	---
YPEL2	388403	broad.mit.edu	37	17	57465633	57465636	+	Intron	DEL	CAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57465633_57465636delCAAA	uc002ixm.1	+							NM_001005404	NP_001005404			yippee-like 2							nucleolus					0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)																	---	---	---	---
TMEM49	81671	broad.mit.edu	37	17	57886365	57886367	+	Intron	DEL	TTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57886365_57886367delTTT	uc002ixu.3	+						TMEM49_uc010wog.1_Intron|TMEM49_uc010woh.1_Intron|TMEM49_uc010woi.1_Intron|TMEM49_uc010woj.1_Intron	NM_030938	NP_112200			transmembrane protein 49						autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)															---	---	---	---
RPS6KB1	6198	broad.mit.edu	37	17	57991981	57991981	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57991981delT	uc002ixy.2	+						RPS6KB1_uc010ddj.1_Intron|RPS6KB1_uc010wom.1_Intron|RPS6KB1_uc010won.1_Intron|RPS6KB1_uc010woo.1_Intron	NM_003161	NP_003152			ribosomal protein S6 kinase, 70kDa, polypeptide						apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			large_intestine(1)	1	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)															---	---	---	---
BRIP1	83990	broad.mit.edu	37	17	59770954	59770955	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:59770954_59770955insA	uc002izk.1	-						BRIP1_uc002izl.1_Intron	NM_032043	NP_114432			BRCA1 interacting protein C-terminal helicase 1						DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1								F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				---	---	---	---
MED13	9969	broad.mit.edu	37	17	60061473	60061474	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60061473_60061474insA	uc002izo.2	-							NM_005121	NP_005112			mediator complex subunit 13						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
MED13	9969	broad.mit.edu	37	17	60072741	60072742	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60072741_60072742insA	uc002izo.2	-							NM_005121	NP_005112			mediator complex subunit 13						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2																		---	---	---	---
EFCAB3	146779	broad.mit.edu	37	17	60483827	60483827	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60483827delT	uc002izu.1	+						EFCAB3_uc010wpc.1_Intron	NM_173503	NP_775774			EF-hand calcium binding domain 3 isoform b								calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)															---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60642339	60642339	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60642339delT	uc010ddp.2	+						TLK2_uc002izx.3_Intron|TLK2_uc002izz.3_Intron|TLK2_uc002jaa.3_Intron|TLK2_uc010wpd.1_Intron	NM_006852	NP_006843			tousled-like kinase 2 isoform A						cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60642665	60642665	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60642665delA	uc010ddp.2	+						TLK2_uc002izx.3_Intron|TLK2_uc002izz.3_Intron|TLK2_uc002jaa.3_Intron|TLK2_uc010wpd.1_Intron	NM_006852	NP_006843			tousled-like kinase 2 isoform A						cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
CCDC47	57003	broad.mit.edu	37	17	61838197	61838200	+	Intron	DEL	AAAA	-	-	rs74805077		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61838197_61838200delAAAA	uc002jbs.3	-						CCDC47_uc010ddx.2_Intron|CCDC47_uc002jbt.2_Intron	NM_020198	NP_064583			coiled-coil domain containing 47 precursor							integral to membrane	protein binding				0																		---	---	---	---
POLG2	11232	broad.mit.edu	37	17	62478940	62478941	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62478940_62478941insA	uc002jei.2	-							NM_007215	NP_009146			DNA polymerase subunit gamma-2, mitochondrial						DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)															---	---	---	---
AXIN2	8313	broad.mit.edu	37	17	63532780	63532780	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63532780delA	uc002jfi.2	-						AXIN2_uc002jfh.2_Intron	NM_004655	NP_004646			axin 2						cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2														Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	63746669	63746669	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:63746669delA	uc002jfl.2	-						CCDC46_uc010deo.2_Intron|CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron|CCDC46_uc002jfk.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
CCDC46	201134	broad.mit.edu	37	17	64171074	64171074	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:64171074delA	uc002jfl.2	-						CCDC46_uc002jfm.2_Intron|CCDC46_uc010dep.2_Intron	NM_145036	NP_659473			coiled-coil domain containing 46 isoform a							centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)															---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65156366	65156366	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65156366delA	uc010wqk.1	-						HELZ_uc002jfv.3_Intron|HELZ_uc002jfx.3_Intron	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
HELZ	9931	broad.mit.edu	37	17	65156546	65156546	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65156546delA	uc010wqk.1	-						HELZ_uc002jfv.3_Intron|HELZ_uc002jfx.3_Intron	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)																	---	---	---	---
NOL11	25926	broad.mit.edu	37	17	65731984	65731984	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65731984delT	uc002jgd.1	+						NOL11_uc010wql.1_Intron|NOL11_uc010deu.1_Intron	NM_015462	NP_056277			nucleolar protein 11							nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65822505	65822505	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65822505delC	uc002jgf.2	+						BPTF_uc002jge.2_Intron|BPTF_uc010wqm.1_Intron	NM_182641	NP_872579			bromodomain PHD finger transcription factor						brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
BPTF	2186	broad.mit.edu	37	17	65944266	65944266	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:65944266delA	uc002jgf.2	+	23	7831	c.7770delA	c.(7768-7770)GCAfs	p.A2590fs	BPTF_uc002jge.2_Frame_Shift_Del_p.A2573fs|BPTF_uc002jgg.2_Frame_Shift_Del_p.A247fs|BPTF_uc002jgh.2_Frame_Shift_Del_p.A49fs	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2716	Potential.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)															---	---	---	---
WIPI1	55062	broad.mit.edu	37	17	66422388	66422390	+	Intron	DEL	AGC	-	-	rs150170943	by1000genomes;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66422388_66422390delAGC	uc010dey.2	-						WIPI1_uc002jhd.3_Intron|WIPI1_uc010wqo.1_Intron|WIPI1_uc002jhe.3_Intron|MIR635_hsa-mir-635|MI0003650_5'Flank	NM_017983	NP_060453			WD repeat domain, phosphoinositide interacting						macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding				0																		---	---	---	---
PRKAR1A	5573	broad.mit.edu	37	17	66520865	66520865	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:66520865delA	uc002jhg.2	+						PRKAR1A_uc002jhh.2_Intron|PRKAR1A_uc002jhi.2_Intron|PRKAR1A_uc002jhj.2_Intron|PRKAR1A_uc002jhk.2_Intron|PRKAR1A_uc002jhl.2_Intron|PRKAR1A_uc002jhm.2_Intron	NM_212471	NP_997636			cAMP-dependent protein kinase, regulatory						activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|lung(3)|thyroid(2)|soft_tissue(2)|breast(1)	12	Breast(10;1.64e-13)							T|Mis|N|F|S	RET	papillary thyroid	myxoma|endocrine|papillary thyroid			Carney_Complex|Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial|Cardiac_Myxomas_Familial_Clustering_of				---	---	---	---
ABCA5	23461	broad.mit.edu	37	17	67246496	67246497	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67246496_67246497delAT	uc002jif.2	-						ABCA5_uc002jib.2_Intron|ABCA5_uc002jic.2_Intron|ABCA5_uc002jid.2_Intron|ABCA5_uc002jie.2_Intron|ABCA5_uc002jig.2_Intron	NM_018672	NP_061142			ATP-binding cassette, sub-family A , member 5						cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)																	---	---	---	---
ABCA5	23461	broad.mit.edu	37	17	67298760	67298760	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67298760delT	uc002jif.2	-						ABCA5_uc002jie.2_Intron|ABCA5_uc002jig.2_Intron|ABCA5_uc002jih.2_Intron|ABCA5_uc010dfe.2_Intron	NM_018672	NP_061142			ATP-binding cassette, sub-family A , member 5						cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)																	---	---	---	---
Unknown	0	broad.mit.edu	37	17	67703569	67703569	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67703569delA								MAP2K6 (165107 upstream) : KCNJ16 (367857 downstream)																																			---	---	---	---
RAB37	326624	broad.mit.edu	37	17	72737075	72737075	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72737075delG	uc002jlk.2	+						RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|RAB37_uc010wrb.1_Intron|RAB37_uc010wrc.1_Intron|RAB37_uc010wrd.1_Intron|RAB37_uc010wre.1_Intron|RAB37_uc002jll.3_Intron	NM_001006638	NP_001006639			RAB37, member RAS oncogene family isoform 2						protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1																		---	---	---	---
GGA3	23163	broad.mit.edu	37	17	73243032	73243032	+	Intron	DEL	A	-	-	rs75940499		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73243032delA	uc002jni.1	-						GGA3_uc002jnj.1_Intron|GGA3_uc010wrw.1_Intron|GGA3_uc002jnk.1_Intron|GGA3_uc010wrx.1_Intron|GGA3_uc010wry.1_Intron|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525			ADP-ribosylation factor binding protein 3						intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)															---	---	---	---
KIAA0195	9772	broad.mit.edu	37	17	73491063	73491063	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73491063delC	uc002jnz.3	+	20	2951	c.2676delC	c.(2674-2676)ATCfs	p.I892fs	KIAA0195_uc010wsa.1_Frame_Shift_Del_p.I902fs|KIAA0195_uc010wsb.1_Frame_Shift_Del_p.I532fs|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	892					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
UNK	85451	broad.mit.edu	37	17	73809978	73809979	+	Intron	INS	-	G	G	rs74319437	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73809978_73809979insG	uc002jpm.2	+							NM_001080419	NP_001073888			zinc finger CCCH-type domain containing 5								nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
MRPL38	64978	broad.mit.edu	37	17	73898037	73898037	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73898037delG	uc010wso.1	-						FBF1_uc002jqa.1_Intron|MRPL38_uc002jpz.1_Intron	NM_032478	NP_115867			mitochondrial ribosomal protein L38 precursor							actin cytoskeleton|mitochondrion|ribosome				pancreas(1)	1			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
EXOC7	23265	broad.mit.edu	37	17	74077588	74077588	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74077588delC	uc002jqs.2	-	20					ZACN_uc002jqn.2_Intron|ZACN_uc002jqo.2_Intron|ZACN_uc010dgu.2_Intron|EXOC7_uc002jqp.1_3'UTR|EXOC7_uc010dgv.1_3'UTR|EXOC7_uc002jqq.2_3'UTR|EXOC7_uc010wsw.1_3'UTR|EXOC7_uc010wsx.1_3'UTR|EXOC7_uc002jqr.2_3'UTR|EXOC7_uc010wsv.1_3'UTR	NM_001145297	NP_001138769			exocyst complex component 7 isoform 4						exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
EXOC7	23265	broad.mit.edu	37	17	74087146	74087146	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74087146delG	uc002jqs.2	-						EXOC7_uc010dgv.1_Intron|EXOC7_uc002jqq.2_Intron|EXOC7_uc010wsw.1_Intron|EXOC7_uc010wsx.1_Intron|EXOC7_uc002jqr.2_Intron|EXOC7_uc010wsv.1_Intron	NM_001145297	NP_001138769			exocyst complex component 7 isoform 4						exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
MFSD11	79157	broad.mit.edu	37	17	74766050	74766051	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74766050_74766051insT	uc002jta.2	+						MFSD11_uc002jtb.2_Intron|MFSD11_uc010dha.2_Intron|MFSD11_uc002jtc.2_Intron|MFSD11_uc002jtd.3_Intron|MFSD11_uc010dhb.2_Intron|MFSD11_uc002jte.2_Intron	NM_024311	NP_077287			major facilitator superfamily domain containing							integral to membrane				ovary(1)	1																		---	---	---	---
CYTH1	9267	broad.mit.edu	37	17	76696614	76696614	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:76696614delT	uc002jvw.2	-						CYTH1_uc010wtw.1_Intron|CYTH1_uc010wtx.1_Intron	NM_017456	NP_059430			cytohesin 1 isoform 2						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1																		---	---	---	---
RPTOR	57521	broad.mit.edu	37	17	78516192	78516192	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:78516192delA	uc002jyt.1	+						RPTOR_uc002jys.2_5'Flank|RPTOR_uc010wuf.1_5'Flank|RPTOR_uc010wug.1_5'Flank|RPTOR_uc002jyr.1_5'Flank	NM_020761	NP_065812			raptor isoform 1						cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6																		---	---	---	---
ASPSCR1	79058	broad.mit.edu	37	17	79953982	79953982	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79953982delA	uc002kcx.2	+						ASPSCR1_uc002kcw.1_Intron|ASPSCR1_uc002kcy.2_Intron|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Intron|ASPSCR1_uc002kdb.1_Intron	NM_024083	NP_076988			alveolar soft part sarcoma chromosome region,								protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)					T	TFE3	alveolar soft part sarcoma								---	---	---	---
ASPSCR1	79058	broad.mit.edu	37	17	79975071	79975071	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79975071delG	uc002kcx.2	+						ASPSCR1_uc002kcy.2_Intron|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Intron	NM_024083	NP_076988			alveolar soft part sarcoma chromosome region,								protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)					T	TFE3	alveolar soft part sarcoma								---	---	---	---
WDR45L	56270	broad.mit.edu	37	17	80585121	80585121	+	Frame_Shift_Del	DEL	T	-	-	rs143489463		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80585121delT	uc002kfq.2	-	4	486	c.291delA	c.(289-291)GAAfs	p.E97fs	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	97					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)															---	---	---	---
ZNF750	79755	broad.mit.edu	37	17	80788099	80788099	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80788099delT	uc002kga.2	-	3	2402	c.2091delA	c.(2089-2091)AAAfs	p.K697fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	697						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)															---	---	---	---
USP14	9097	broad.mit.edu	37	18	198243	198243	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:198243delT	uc002kkf.1	+						USP14_uc002kkg.1_Intron|USP14_uc010wyr.1_Intron	NM_005151	NP_005142			ubiquitin specific protease 14 isoform a						regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)																---	---	---	---
THOC1	9984	broad.mit.edu	37	18	226749	226749	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:226749delT	uc002kkj.3	-						THOC1_uc002kkk.3_Intron|THOC1_uc002kkl.2_Intron|THOC1_uc002kkh.3_5'Flank	NM_005131	NP_005122			THO complex 1						apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)																---	---	---	---
COLEC12	81035	broad.mit.edu	37	18	321885	321886	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:321885_321886insA	uc002kkm.2	-							NM_130386	NP_569057			collectin sub-family member 12						carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)																---	---	---	---
SMCHD1	23347	broad.mit.edu	37	18	2722732	2722732	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2722732delT	uc002klm.3	+						SMCHD1_uc002klk.3_Intron|SMCHD1_uc002kll.3_Intron	NM_015295	NP_056110			structural maintenance of chromosomes flexible						chromosome organization		ATP binding				0																		---	---	---	---
EMILIN2	84034	broad.mit.edu	37	18	2847701	2847702	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2847701_2847702insC	uc002kln.2	+							NM_032048	NP_114437			elastin microfibril interfacer 2 precursor						cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)														---	---	---	---
LPIN2	9663	broad.mit.edu	37	18	2929015	2929015	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2929015delA	uc002klo.2	-							NM_014646	NP_055461			lipin 2						fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)														---	---	---	---
LPIN2	9663	broad.mit.edu	37	18	2934455	2934455	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:2934455delA	uc002klo.2	-							NM_014646	NP_055461			lipin 2						fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)														---	---	---	---
MYL12B	103910	broad.mit.edu	37	18	3272865	3272865	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3272865delT	uc010dkl.2	+						MYL12B_uc002klt.3_Intron|MYL12B_uc010wyv.1_Intron	NM_001144944	NP_001138416			myosin regulatory light chain MRCL2 isoform A						axon guidance|muscle contraction	cytosol|myosin complex	calcium ion binding				0																		---	---	---	---
EPB41L3	23136	broad.mit.edu	37	18	5424365	5424365	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:5424365delA	uc002kmt.1	-						EPB41L3_uc010wzh.1_Intron|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc010dkr.2_5'Flank	NM_012307	NP_036439			erythrocyte membrane protein band 4.1-like 3						cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5																		---	---	---	---
PTPRM	5797	broad.mit.edu	37	18	8384458	8384458	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:8384458delA	uc002knn.3	+						PTPRM_uc010dkv.2_Intron|PTPRM_uc010wzl.1_Intron	NM_002845	NP_002836			protein tyrosine phosphatase, receptor type, M						homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)																---	---	---	---
RALBP1	10928	broad.mit.edu	37	18	9525921	9525921	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9525921delT	uc002kob.2	+						RALBP1_uc002koc.2_Intron	NM_006788	NP_006779			ralA binding protein 1						chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1																		---	---	---	---
TXNDC2	84203	broad.mit.edu	37	18	9887814	9887814	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:9887814delG	uc002koi.3	+	2	1787	c.1338delG	c.(1336-1338)GAGfs	p.E446fs	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Frame_Shift_Del_p.E379fs	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	446	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2																		---	---	---	---
NAPG	8774	broad.mit.edu	37	18	10548537	10548539	+	Intron	DEL	TTT	-	-	rs1662154		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:10548537_10548539delTTT	uc002kon.2	+						NAPG_uc010wzr.1_Intron|NAPG_uc002koo.2_Intron|NAPG_uc002kop.2_Intron	NM_003826	NP_003817			N-ethylmaleimide-sensitive factor attachment						cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0																		---	---	---	---
MPPE1	65258	broad.mit.edu	37	18	11886304	11886304	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:11886304delA	uc002kqf.2	-						MPPE1_uc002kqn.2_Intron|MPPE1_uc002kqg.2_Intron|MPPE1_uc002kqh.2_Intron|MPPE1_uc002kqi.2_Intron|MPPE1_uc002kqj.2_Intron|MPPE1_uc002kqk.2_Intron|MPPE1_uc002kql.2_Intron|MPPE1_uc002kqm.2_Intron|MPPE1_uc010dla.1_3'UTR	NM_023075	NP_075563			metallophosphoesterase 1 precursor						ER to Golgi vesicle-mediated transport|GPI anchor biosynthetic process	cis-Golgi network|endoplasmic reticulum exit site|ER-Golgi intermediate compartment membrane|integral to membrane	GPI anchor binding|manganese ion binding|phosphoric diester hydrolase activity				0																		---	---	---	---
AFG3L2	10939	broad.mit.edu	37	18	12337293	12337293	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12337293delT	uc002kqz.1	-							NM_006796	NP_006787			AFG3 ATPase family gene 3-like 2						cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)													---	---	---	---
Unknown	0	broad.mit.edu	37	18	14888903	14888906	+	IGR	DEL	AAAC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:14888903_14888906delAAAC								ANKRD30B (36166 upstream) : LOC644669 (424649 downstream)																																			---	---	---	---
ROCK1	6093	broad.mit.edu	37	18	18540011	18540011	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:18540011delA	uc002kte.2	-							NM_005406	NP_005397			Rho-associated, coiled-coil containing protein						actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)																	---	---	---	---
OSBPL1A	114876	broad.mit.edu	37	18	21750331	21750331	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21750331delT	uc002kve.2	-	24	2552	c.2378delA	c.(2377-2379)AATfs	p.N793fs	OSBPL1A_uc002kvd.2_Frame_Shift_Del_p.N280fs|OSBPL1A_uc010xbc.1_Frame_Shift_Del_p.N411fs	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	793					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)																	---	---	---	---
IMPACT	55364	broad.mit.edu	37	18	22029771	22029771	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:22029771delA	uc002kvh.3	+						IMPACT_uc002kvg.3_Intron	NM_018439	NP_060909			Impact homolog												0	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)																	---	---	---	---
TAF4B	6875	broad.mit.edu	37	18	23807321	23807321	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:23807321delA	uc002kvu.3	+						TAF4B_uc002kvs.3_Intron|TAF4B_uc002kvt.3_Intron	NM_005640	NP_005631			TAF4b RNA polymerase II, TATA box binding						transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)															---	---	---	---
CDH2	1000	broad.mit.edu	37	18	25593923	25593923	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:25593923delA	uc002kwg.2	-						CDH2_uc010xbn.1_Intron	NM_001792	NP_001783			cadherin 2, type 1 preproprotein						adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4																		---	---	---	---
DSC3	1825	broad.mit.edu	37	18	28588133	28588133	+	Intron	DEL	A	-	-	rs34151598		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28588133delA	uc002kwj.3	-						DSC3_uc002kwi.3_Intron	NM_001941	NP_001932			desmocollin 3 isoform Dsc3a preproprotein						homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)															---	---	---	---
DSC1	1823	broad.mit.edu	37	18	28710682	28710682	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28710682delA	uc002kwn.2	-						DSC1_uc002kwm.2_Intron|uc002kwo.1_5'Flank	NM_024421	NP_077739			desmocollin 1 isoform Dsc1a preproprotein						homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)															---	---	---	---
DSG4	147409	broad.mit.edu	37	18	28968816	28968817	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28968816_28968817insT	uc002kwq.2	+						DSG4_uc002kwr.2_Intron	NM_177986	NP_817123			desmoglein 4 isoform 2 preproprotein						homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)															---	---	---	---
DSG4	147409	broad.mit.edu	37	18	28985982	28985982	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:28985982delC	uc002kwq.2	+						DSG4_uc002kwr.2_Intron	NM_177986	NP_817123			desmoglein 4 isoform 2 preproprotein						homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)															---	---	---	---
KIAA1012	22878	broad.mit.edu	37	18	29432298	29432299	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29432298_29432299insC	uc002kxc.3	-						KIAA1012_uc002kxb.3_Intron|KIAA1012_uc002kxd.3_Intron	NM_014939	NP_055754			hypothetical protein LOC22878						ER to Golgi vesicle-mediated transport	cis-Golgi network					0																		---	---	---	---
MEP1B	4225	broad.mit.edu	37	18	29797210	29797210	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29797210delT	uc002kxj.3	+							NM_005925	NP_005916			meprin A beta precursor						digestion|proteolysis	extracellular space|integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)	2																		---	---	---	---
KLHL14	57565	broad.mit.edu	37	18	30260121	30260121	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30260121delA	uc002kxm.1	-						KLHL14_uc010dmd.1_Intron	NM_020805	NP_065856			kelch-like 14							cytosol|endoplasmic reticulum membrane				ovary(1)	1																		---	---	---	---
C18orf34	374864	broad.mit.edu	37	18	30913143	30913144	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30913143_30913144delTT	uc002kxn.2	-	9	1015_1016	c.873_874delAA	c.(871-876)AAAATGfs	p.K291fs	C18orf34_uc010xbr.1_Frame_Shift_Del_p.K291fs|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Frame_Shift_Del_p.K291fs|C18orf34_uc002kxp.2_Frame_Shift_Del_p.K291fs	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	291_292	Potential.									ovary(1)	1																		---	---	---	---
DTNA	1837	broad.mit.edu	37	18	32405028	32405028	+	Intron	DEL	T	-	-	rs77685796		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:32405028delT	uc010dmn.1	+						DTNA_uc002kxu.2_Intron|DTNA_uc010xbx.1_Intron|DTNA_uc002kxv.3_Intron|DTNA_uc002kxw.2_Intron|DTNA_uc002kxx.2_Intron|DTNA_uc010dmj.2_Intron|DTNA_uc002kxz.2_Intron|DTNA_uc002kxy.2_Intron|DTNA_uc010dmk.1_Intron|DTNA_uc010dml.2_Intron|DTNA_uc002kyb.3_Intron|DTNA_uc010dmm.2_Intron|DTNA_uc010xby.1_Intron|DTNA_uc010dmo.2_Intron|DTNA_uc002kyd.3_Intron|DTNA_uc010xbz.1_Intron|DTNA_uc010xca.1_Intron|DTNA_uc002kye.2_Intron	NM_001390	NP_001381			dystrobrevin alpha isoform 1						neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0																		---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33800306	33800310	+	Intron	DEL	AAAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33800306_33800310delAAAAA	uc002kzq.3	+							NM_017947	NP_060417			molybdenum cofactor sulfurase						Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
KIAA1328	57536	broad.mit.edu	37	18	34424156	34424156	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:34424156delT	uc002kzz.2	+							NM_020776	NP_065827			hypothetical protein LOC57536											central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)														---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43437680	43437680	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43437680delT	uc002lbm.2	-							NM_020964	NP_066015			hypothetical protein LOC57724						autophagy						0																		---	---	---	---
KIAA1632	57724	broad.mit.edu	37	18	43529364	43529365	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43529364_43529365insT	uc002lbm.2	-						KIAA1632_uc002lbo.1_Intron	NM_020964	NP_066015			hypothetical protein LOC57724						autophagy						0																		---	---	---	---
PSTPIP2	9050	broad.mit.edu	37	18	43595906	43595906	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43595906delA	uc002lbp.3	-						PSTPIP2_uc002lbq.3_Intron	NM_024430	NP_077748			proline-serine-threonine phosphatase interacting							membrane				ovary(1)	1																		---	---	---	---
RNF165	494470	broad.mit.edu	37	18	43914205	43914207	+	5'UTR	DEL	GCC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:43914205_43914207delGCC	uc002lcb.1	+	1					RNF165_uc002lby.1_Intron|RNF165_uc010dnn.1_5'UTR|RNF165_uc002lbz.2_RNA|RNF165_uc002lca.1_RNA|uc002lcc.1_5'Flank	NM_152470	NP_689683			ring finger protein 165								zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)														---	---	---	---
ZBTB7C	201501	broad.mit.edu	37	18	45567076	45567076	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:45567076delC	uc002lda.2	-	1	419	c.403delG	c.(403-405)GAGfs	p.E135fs	ZBTB7C_uc002ldb.2_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dnu.2_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010dnv.2_Frame_Shift_Del_p.E157fs|ZBTB7C_uc010dnw.2_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dnx.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dny.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dnz.1_Frame_Shift_Del_p.E157fs|ZBTB7C_uc010dob.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010doc.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010dod.1_Frame_Shift_Del_p.E157fs|ZBTB7C_uc010doe.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dof.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dog.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010doh.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010doi.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010doj.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010dok.1_Frame_Shift_Del_p.E184fs|ZBTB7C_uc010dol.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010doa.1_Frame_Shift_Del_p.E157fs|ZBTB7C_uc010don.1_Frame_Shift_Del_p.E143fs|ZBTB7C_uc010doo.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dop.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010doq.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010dor.1_Frame_Shift_Del_p.E157fs|ZBTB7C_uc010dos.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dot.1_Frame_Shift_Del_p.E135fs|ZBTB7C_uc010dou.1_Frame_Shift_Del_p.E144fs|ZBTB7C_uc010dom.1_Frame_Shift_Del_p.E144fs	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	135	Glu-rich.|Asp-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1																		---	---	---	---
MYO5B	4645	broad.mit.edu	37	18	47518830	47518830	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:47518830delA	uc002leb.2	-						MYO5B_uc002lec.1_Intron	NM_001080467	NP_001073936			myosin VB						protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)														---	---	---	---
SMAD4	4089	broad.mit.edu	37	18	48603248	48603248	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:48603248delT	uc010xdp.1	+						SMAD4_uc002lfb.3_Intron	NM_005359	NP_005350			mothers against decapentaplegic homolog 4						BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)										Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				---	---	---	---
CCDC68	80323	broad.mit.edu	37	18	52608329	52608329	+	Intron	DEL	C	-	-	rs142551755		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52608329delC	uc002lfs.2	-						CCDC68_uc002lft.2_Intron	NM_001143829	NP_001137301			coiled-coil domain containing 68											skin(1)	1				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54361838	54361838	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54361838delT	uc002lgk.1	+						WDR7_uc010dpk.1_Intron|WDR7_uc002lgl.1_Intron	NM_015285	NP_056100			rabconnectin-3 beta isoform 1											ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
ATP8B1	5205	broad.mit.edu	37	18	55329760	55329760	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55329760delA	uc002lgw.2	-	20	2373	c.2373delT	c.(2371-2373)TTTfs	p.F791fs	uc002lgu.1_Intron|uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	791	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)												Byler_disease				---	---	---	---
NEDD4L	23327	broad.mit.edu	37	18	55992061	55992061	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:55992061delT	uc002lgy.2	+						NEDD4L_uc002lgz.2_Intron|NEDD4L_uc002lgx.2_Intron|NEDD4L_uc010xee.1_Intron|NEDD4L_uc002lhc.2_Intron|NEDD4L_uc002lhd.2_Intron|NEDD4L_uc002lhb.2_Intron|NEDD4L_uc002lhe.2_Intron|NEDD4L_uc002lhf.2_Intron|NEDD4L_uc002lhg.2_Intron|NEDD4L_uc002lhh.2_Intron|NEDD4L_uc010dpm.1_Intron	NM_001144967	NP_001138439			neural precursor cell expressed, developmentally						cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	18	57429205	57429205	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:57429205delA								CCBE1 (64561 upstream) : PMAIP1 (137987 downstream)																																			---	---	---	---
KIAA1468	57614	broad.mit.edu	37	18	59894429	59894430	+	Intron	DEL	AA	-	-	rs35190394		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:59894429_59894430delAA	uc002lil.2	+						KIAA1468_uc002lik.1_Intron|KIAA1468_uc010xel.1_Intron|KIAA1468_uc002lim.2_Intron	NM_020854	NP_065905			hypothetical protein LOC57614								binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)																---	---	---	---
RTTN	25914	broad.mit.edu	37	18	67721312	67721312	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:67721312delT	uc002lkp.2	-						RTTN_uc002lko.2_Intron|RTTN_uc010xfb.1_Intron|RTTN_uc010dqp.2_Intron	NM_173630	NP_775901			rotatin								binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)																---	---	---	---
NETO1	81832	broad.mit.edu	37	18	70526037	70526037	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:70526037delT	uc002lkw.2	-						NETO1_uc002lkx.1_Intron|NETO1_uc002lky.1_Intron|NETO1_uc002lkz.2_Intron	NM_138966	NP_620416			neuropilin- and tolloid-like protein 1 isoform 3						memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)														---	---	---	---
ZNF236	7776	broad.mit.edu	37	18	74617099	74617099	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74617099delT	uc002lmi.2	+						ZNF236_uc002lmj.2_Intron	NM_007345	NP_031371			zinc finger protein 236						cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)														---	---	---	---
CTDP1	9150	broad.mit.edu	37	18	77470532	77470532	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77470532delT	uc002lnh.1	+						CTDP1_uc002lni.1_Intron|CTDP1_uc010drd.1_Intron	NM_004715	NP_004706			CTD (carboxy-terminal domain, RNA polymerase II,						positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)														---	---	---	---
POLRMT	5442	broad.mit.edu	37	19	619355	619355	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:619355delC	uc002lpf.1	-							NM_005035	NP_005026			mitochondrial DNA-directed RNA polymerase						transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
GRIN3B	116444	broad.mit.edu	37	19	1008813	1008813	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1008813delC	uc002lqo.1	+						uc002lqp.1_RNA	NM_138690	NP_619635			glutamate receptor, ionotropic,						ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)													---	---	---	---
C19orf26	255057	broad.mit.edu	37	19	1231206	1231206	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1231206delC	uc002lrm.2	-	9	1305	c.1030delG	c.(1030-1032)GATfs	p.D344fs		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	370						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)											HNSCC(14;0.022)			---	---	---	---
APC2	10297	broad.mit.edu	37	19	1461863	1461863	+	Intron	DEL	C	-	-	rs9916972		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1461863delC	uc002lsr.1	+						APC2_uc002lss.1_Intron|APC2_uc002lst.1_Intron|APC2_uc002lsu.1_Intron|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874			adenomatosis polyposis coli 2						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ATP8B3	148229	broad.mit.edu	37	19	1795906	1795906	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1795906delC	uc002ltw.2	-	18	2257	c.2023delG	c.(2023-2025)GCAfs	p.A675fs	ATP8B3_uc002ltv.2_Frame_Shift_Del_p.A628fs|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	675	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)												OREG0025127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
BTBD2	55643	broad.mit.edu	37	19	1997185	1997186	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1997185_1997186delAA	uc002lup.1	-							NM_017797	NP_060267			BTB (POZ) domain containing 2							cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
DOT1L	84444	broad.mit.edu	37	19	2226423	2226423	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2226423delG	uc002lvb.3	+	27	3939	c.3903delG	c.(3901-3903)TCGfs	p.S1301fs	DOT1L_uc002lvc.1_Frame_Shift_Del_p.S595fs	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1301						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
C19orf28	126321	broad.mit.edu	37	19	3544980	3544980	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3544980delC	uc002lxz.2	-						C19orf28_uc002lxw.2_Intron|C19orf28_uc002lxx.2_Intron|C19orf28_uc002lxy.2_Intron	NM_174983	NP_778148			hypothetical protein LOC126321 isoform c						transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)												OREG0025153	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZFR2	23217	broad.mit.edu	37	19	3871980	3871980	+	5'Flank	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3871980delA	uc002lyw.2	-						ZFR2_uc010xhx.1_5'Flank|ZFR2_uc002lyx.3_5'Flank|ZFR2_uc010xhy.1_5'Flank	NM_015174	NP_055989			zinc finger RNA binding protein 2 isoform 1							intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)														---	---	---	---
DAPK3	1613	broad.mit.edu	37	19	3961351	3961351	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3961351delC	uc002lzc.1	-						DAPK3_uc002lzb.1_5'UTR|DAPK3_uc002lzd.1_Intron	NM_001348	NP_001339			death-associated protein kinase 3						apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
CCDC94	55702	broad.mit.edu	37	19	4261827	4261827	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4261827delA	uc002lzv.3	+							NM_018074	NP_060544			coiled-coil domain containing 94												0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)														---	---	---	---
CHAF1A	10036	broad.mit.edu	37	19	4423947	4423947	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4423947delC	uc002mal.2	+							NM_005483	NP_005474			chromatin assembly factor 1, subunit A (p150)						cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)									Chromatin_Structure					---	---	---	---
SAFB2	9667	broad.mit.edu	37	19	5587282	5587282	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5587282delG	uc002mcd.2	-	21	3046	c.2834delC	c.(2833-2835)CCGfs	p.P945fs		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	945	Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)														---	---	---	---
SAFB2	9667	broad.mit.edu	37	19	5605120	5605121	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5605120_5605121insG	uc002mcd.2	-							NM_014649	NP_055464			scaffold attachment factor B2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)														---	---	---	---
TMEM146	257062	broad.mit.edu	37	19	5727207	5727207	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5727207delA	uc002mda.2	+						TMEM146_uc010duj.1_Intron	NM_152784	NP_689997			transmembrane protein 146 precursor							integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
DENND1C	79958	broad.mit.edu	37	19	6477251	6477251	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6477251delG	uc002mfe.2	-	8	583	c.491delC	c.(490-492)CCTfs	p.P164fs	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Frame_Shift_Del_p.P120fs	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	164	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1																		---	---	---	---
SH2D3A	10045	broad.mit.edu	37	19	6754580	6754581	+	Intron	DEL	GG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6754580_6754581delGG	uc002mft.2	-						SH2D3A_uc010xjg.1_Intron	NM_005490	NP_005481			SH2 domain containing 3A						JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2																		---	---	---	---
ARHGEF18	23370	broad.mit.edu	37	19	7512065	7512066	+	Intron	DEL	TT	-	-	rs59050162	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7512065_7512066delTT	uc002mgi.2	+						ARHGEF18_uc010xjm.1_Intron|ARHGEF18_uc002mgh.2_Intron|ARHGEF18_uc002mgj.1_Intron	NM_001130955	NP_001124427			Rho/Rac guanine nucleotide exchange factor 18						actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)																---	---	---	---
EVI5L	115704	broad.mit.edu	37	19	7914226	7914227	+	Intron	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7914226_7914227insG	uc002min.2	+						EVI5L_uc010xjz.1_Intron|EVI5L_uc002mio.1_5'Flank	NM_145245	NP_660288			ecotropic viral integration site 5-like isoform							intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1																		---	---	---	---
ELAVL1	1994	broad.mit.edu	37	19	8028348	8028348	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8028348delA	uc002mjb.2	-	6						NM_001419	NP_001410			ELAV-like 1						3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0																		---	---	---	---
ADAMTS10	81794	broad.mit.edu	37	19	8650584	8650584	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8650584delG	uc002mkj.1	-						ADAMTS10_uc002mki.1_Intron|ADAMTS10_uc002mkk.1_Intron	NM_030957	NP_112219			ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4																OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10081540	10081541	+	Intron	INS	-	A	A	rs2287815		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10081540_10081541insA	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10091451	10091451	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10091451delG	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10106361	10106361	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10106361delA	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
ATG4D	84971	broad.mit.edu	37	19	10659805	10659805	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10659805delT	uc002mov.2	+						ATG4D_uc010xlh.1_Intron|ATG4D_uc010dxh.2_Intron|ATG4D_uc010dxi.2_Intron|ATG4D_uc010dxj.2_Intron|MIR1238_hsa-mir-1238|MI0006328_5'Flank	NM_032885	NP_116274			APG4 autophagy 4 homolog D						autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)															---	---	---	---
AP1M2	10053	broad.mit.edu	37	19	10694151	10694151	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10694151delA	uc002mpc.2	-						AP1M2_uc002mpd.2_Intron	NM_005498	NP_005489			adaptor-related protein complex 1, mu 2 subunit						cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)															---	---	---	---
DOCK6	57572	broad.mit.edu	37	19	11326765	11326769	+	Intron	DEL	AATTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11326765_11326769delAATTT	uc002mqs.3	-						DOCK6_uc010xlq.1_Intron	NM_020812	NP_065863			dedicator of cytokinesis 6						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3																		---	---	---	---
RGL3	57139	broad.mit.edu	37	19	11517667	11517668	+	Intron	DEL	TT	-	-	rs5827125		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11517667_11517668delTT	uc002mrp.2	-						RGL3_uc002mrn.2_Intron|RGL3_uc002mrm.2_Intron|RGL3_uc002mro.2_Intron	NM_001035223	NP_001030300			ral guanine nucleotide dissociation						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1																		---	---	---	---
ELAVL3	1995	broad.mit.edu	37	19	11565285	11565286	+	3'UTR	DEL	TC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11565285_11565286delTC	uc002mry.1	-	7					ELAVL3_uc002mrx.1_3'UTR	NM_001420	NP_001411			ELAV-like protein 3 isoform 1						cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
CACNA1A	773	broad.mit.edu	37	19	13323124	13323124	+	Intron	DEL	T	-	-	rs16048	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13323124delT	uc010dze.2	-						CACNA1A_uc010xnd.1_Intron|CACNA1A_uc002mwx.3_Intron|CACNA1A_uc010dzc.2_Intron|CACNA1A_uc002mwy.3_Intron|CACNA1A_uc002mwv.3_Intron	NM_001127221	NP_001120693			calcium channel, alpha 1A subunit isoform 3						cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)													---	---	---	---
EMR3	84658	broad.mit.edu	37	19	14762192	14762192	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14762192delA	uc002mzi.3	-						EMR3_uc010dzp.2_Intron|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960			egf-like module-containing mucin-like receptor						neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6																		---	---	---	---
EMR2	30817	broad.mit.edu	37	19	14854057	14854058	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14854057_14854058insA	uc002mzp.1	-						EMR2_uc010dzs.1_Intron|EMR2_uc010xnw.1_Intron|EMR2_uc002mzo.1_Intron|EMR2_uc002mzq.1_Intron|EMR2_uc002mzr.1_Intron|EMR2_uc002mzs.1_Intron|EMR2_uc002mzt.1_Intron|EMR2_uc002mzu.1_Intron	NM_013447	NP_038475			egf-like module containing, mucin-like, hormone						cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4																		---	---	---	---
NOTCH3	4854	broad.mit.edu	37	19	15302528	15302528	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15302528delC	uc002nan.2	-						NOTCH3_uc002nao.1_Intron	NM_000435	NP_000426			Notch homolog 3 precursor						Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	15722435	15722436	+	IGR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15722435_15722436insA								CYP4F22 (59308 upstream) : CYP4F8 (3593 downstream)																																			---	---	---	---
CYP4F8	11283	broad.mit.edu	37	19	15733195	15733195	+	Intron	DEL	T	-	-	rs2072601	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:15733195delT	uc002nbi.2	+						CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184			cytochrome P450, family 4, subfamily F,						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1																		---	---	---	---
TPM4	7171	broad.mit.edu	37	19	16199871	16199873	+	In_Frame_Del	DEL	GAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16199871_16199873delGAA	uc002ndj.2	+	5	713_715	c.472_474delGAA	c.(472-474)GAAdel	p.E160del	TPM4_uc002ndi.2_In_Frame_Del_p.E196del|TPM4_uc002ndk.1_In_Frame_Del_p.E70del	NM_003290	NP_003281	P67936	TPM4_HUMAN	tropomyosin 4 isoform 2	160	By similarity.				cellular component movement|muscle filament sliding|response to oxidative stress	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding|calcium ion binding|structural constituent of muscle		TPM4/ALK(12)	soft_tissue(10)|haematopoietic_and_lymphoid_tissue(2)|breast(1)	13								T	ALK	ALCL						OREG0025329	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
HAUS8	93323	broad.mit.edu	37	19	17186232	17186232	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17186232delT	uc002nfe.2	-	1	112	c.1delA	c.(1-3)ATGfs	p.M1fs	HAUS8_uc002nff.2_Frame_Shift_Del_p.M1fs|HAUS8_uc002nfg.1_Translation_Start_Site|HAUS8_uc002nfh.1_Frame_Shift_Del_p.M1fs|MYO9B_uc002nfi.2_5'Flank|MYO9B_uc010eak.2_5'Flank	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	1					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0																		---	---	---	---
MYO9B	4650	broad.mit.edu	37	19	17294680	17294680	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17294680delA	uc010eak.2	+						MYO9B_uc002nfi.2_Intron|MYO9B_uc002nfj.1_Intron	NM_004145	NP_004136			myosin IXB isoform 1						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1																		---	---	---	---
OCEL1	79629	broad.mit.edu	37	19	17338803	17338803	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17338803delC	uc002nfp.2	+	4	609	c.607delC	c.(607-609)CCCfs	p.P203fs		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	203										central_nervous_system(1)	1																		---	---	---	---
PIK3R2	5296	broad.mit.edu	37	19	18273703	18273703	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18273703delA	uc002nia.1	+						PIK3R2_uc002nib.1_Intron|PIK3R2_uc010ebi.1_Intron	NM_005027	NP_005018			phosphoinositide-3-kinase, regulatory subunit 2						fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
CRLF1	9244	broad.mit.edu	37	19	18707343	18707343	+	Intron	DEL	A	-	-	rs78616489		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18707343delA	uc010ebt.1	-							NM_004750	NP_004741			cytokine receptor-like factor 1 precursor						negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1																		---	---	---	---
GATAD2A	54815	broad.mit.edu	37	19	19606517	19606517	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19606517delG	uc010xqt.1	+						GATAD2A_uc010xqu.1_Intron|GATAD2A_uc010xqv.1_Intron|GATAD2A_uc010xqw.1_Intron	NM_017660	NP_060130			GATA zinc finger domain containing 2A						DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	20861476	20861476	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20861476delA								ZNF626 (17074 upstream) : ZNF85 (244604 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	20874262	20874262	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:20874262delA								ZNF626 (29860 upstream) : ZNF85 (231818 downstream)																																			---	---	---	---
ZNF100	163227	broad.mit.edu	37	19	21948698	21948698	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21948698delA	uc002nqi.2	-							NM_173531	NP_775802			zinc finger protein 100						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
Unknown	0	broad.mit.edu	37	19	22647391	22647391	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:22647391delA								ZNF98 (42243 upstream) : ZNF492 (169735 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	19	23317115	23317115	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:23317115delT	uc002nrb.1	+											Homo sapiens cDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85.																														---	---	---	---
ZNF254	9534	broad.mit.edu	37	19	24309043	24309044	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:24309043_24309044insT	uc002nru.2	+						ZNF254_uc010xrk.1_Intron	NM_203282	NP_975011			zinc finger protein 254						negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)																---	---	---	---
CCNE1	898	broad.mit.edu	37	19	30314459	30314459	+	Intron	DEL	A	-	-	rs4805483	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30314459delA	uc002nsn.2	+						CCNE1_uc002nso.2_Intron|CCNE1_uc002nsp.2_Intron	NM_001238	NP_001229			cyclin E1 isoform 1						androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)															---	---	---	---
C19orf2	8725	broad.mit.edu	37	19	30496755	30496755	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:30496755delT	uc002nsr.2	+						C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Intron|C19orf2_uc002nst.2_Intron	NM_003796	NP_003787			RPB5-mediating protein isoform a						protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TSHZ3	57616	broad.mit.edu	37	19	31770731	31770731	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31770731delA	uc002nsy.3	-							NM_020856	NP_065907			zinc finger protein 537						negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)																	---	---	---	---
ANKRD27	84079	broad.mit.edu	37	19	33113679	33113679	+	Intron	DEL	T	-	-	rs77974943		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33113679delT	uc002ntn.1	-							NM_032139	NP_115515			ankyrin repeat domain 27 (VPS9 domain)						early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)																	---	---	---	---
CCDC123	84902	broad.mit.edu	37	19	33439158	33439158	+	Intron	DEL	T	-	-	rs12710001	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:33439158delT	uc002nty.2	-						CCDC123_uc002ntx.2_Intron|CCDC123_uc010edg.2_Intron|CCDC123_uc002ntz.1_Intron|CCDC123_uc002nua.2_Intron|CCDC123_uc002nub.1_Intron	NM_032816	NP_116205			coiled-coil domain containing 123							centrosome|spindle pole					0	Esophageal squamous(110;0.137)																	---	---	---	---
LSM14A	26065	broad.mit.edu	37	19	34718251	34718252	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34718251_34718252insT	uc002nvb.3	+						LSM14A_uc002nva.3_Intron|LSM14A_uc010xru.1_Intron|LSM14A_uc002nvc.3_Intron	NM_001114093	NP_001107565			LSM14 homolog A isoform a						cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				skin(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34819146	34819146	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34819146delA	uc002nvd.3	+							NM_014686	NP_055501			hypothetical protein LOC9710											ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34832293	34832294	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34832293_34832294delTT	uc002nvd.3	+							NM_014686	NP_055501			hypothetical protein LOC9710											ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
FXYD7	53822	broad.mit.edu	37	19	35639556	35639556	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35639556delT	uc002nye.1	+						FXYD7_uc010xsp.1_Intron|FXYD7_uc002nyf.1_Intron	NM_022006	NP_071289			FXYD domain-containing ion transport regulator							integral to membrane	ion channel activity				0	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)															---	---	---	---
WDR62	284403	broad.mit.edu	37	19	36593174	36593174	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36593174delT	uc002odc.2	+						WDR62_uc002odd.2_Intron	NM_173636	NP_775907			WD repeat domain 62 isoform 2						cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
COX7A1	1346	broad.mit.edu	37	19	36642553	36642553	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36642553delC	uc002odm.1	-							NM_001864	NP_001855			cytochrome c oxidase subunit VIIa polypeptide 1						generation of precursor metabolites and energy	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)															---	---	---	---
Unknown	0	broad.mit.edu	37	19	38229125	38229126	+	IGR	INS	-	T	T	rs111332337		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38229125_38229126insT								ZNF607 (18434 upstream) : ZNF573 (77 downstream)																																			---	---	---	---
RYR1	6261	broad.mit.edu	37	19	38991086	38991086	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38991086delG	uc002oit.2	+						RYR1_uc002oiu.2_Intron|RYR1_uc002oiv.1_Intron	NM_000540	NP_000531			skeletal muscle ryanodine receptor isoform 1						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)													---	---	---	---
ACTN4	81	broad.mit.edu	37	19	39212363	39212364	+	Intron	DEL	CT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39212363_39212364delCT	uc002oja.1	+						ACTN4_uc010egc.1_Frame_Shift_Del_p.L493fs	NM_004924	NP_004915			actinin, alpha 4						platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
HNRNPL	3191	broad.mit.edu	37	19	39330958	39330959	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39330958_39330959insG	uc010xul.1	-	8	1021_1022	c.1010_1011insC	c.(1009-1011)CCAfs	p.P337fs	HNRNPL_uc010ege.1_5'UTR|HNRNPL_uc002ojj.1_5'UTR|HNRNPL_uc002ojo.1_5'Flank|HNRNPL_uc002ojk.2_5'UTR|HNRNPL_uc002ojl.2_5'UTR|HNRNPL_uc010xum.1_Frame_Shift_Ins_p.P204fs|HNRNPL_uc002ojp.1_5'UTR|HNRNPL_uc010xun.1_Frame_Shift_Ins_p.H45fs	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	337	Pro-rich.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)															---	---	---	---
PAK4	10298	broad.mit.edu	37	19	39664319	39664319	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39664319delC	uc002okj.1	+	6	1228	c.767delC	c.(766-768)GCCfs	p.A256fs	PAK4_uc002okl.1_Frame_Shift_Del_p.A256fs|PAK4_uc002okn.1_Frame_Shift_Del_p.A256fs|PAK4_uc002okm.1_Frame_Shift_Del_p.A103fs|PAK4_uc002oko.1_Frame_Shift_Del_p.A103fs|PAK4_uc002okp.1_Frame_Shift_Del_p.A166fs	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	256	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)															---	---	---	---
FCGBP	8857	broad.mit.edu	37	19	40421005	40421005	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40421005delC	uc002omp.3	-							NM_003890	NP_003881			Fc fragment of IgG binding protein precursor							extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41066082	41066082	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41066082delG	uc002ony.2	+	27	5774	c.5688delG	c.(5686-5688)GAGfs	p.E1896fs	SPTBN4_uc002onx.2_Frame_Shift_Del_p.E1896fs|SPTBN4_uc002onz.2_Frame_Shift_Del_p.E1896fs|SPTBN4_uc010egx.2_Frame_Shift_Del_p.E639fs|SPTBN4_uc002ooa.2_Frame_Shift_Del_p.E572fs	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1896	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SHKBP1	92799	broad.mit.edu	37	19	41083376	41083376	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41083376delG	uc002oob.2	+						SHKBP1_uc002ooc.2_Intron|SHKBP1_uc002ood.2_Intron|SHKBP1_uc010xvl.1_Intron|SHKBP1_uc002ooe.2_Intron|SHKBP1_uc002oof.2_5'Flank|SHKBP1_uc010xvm.1_5'Flank|SHKBP1_uc010xvn.1_5'Flank	NM_138392	NP_612401			SH3KBP1 binding protein 1							voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
CIC	23152	broad.mit.edu	37	19	42794441	42794441	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42794441delC	uc002otf.1	+	10	1561	c.1521delC	c.(1519-1521)CGCfs	p.R507fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)						T	DUX4	soft tissue sarcoma								---	---	---	---
CIC	23152	broad.mit.edu	37	19	42795962	42795962	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42795962delT	uc002otf.1	+							NM_015125	NP_055940			capicua homolog						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)						T	DUX4	soft tissue sarcoma								---	---	---	---
PSG6	5675	broad.mit.edu	37	19	43460948	43460948	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43460948delA	uc002ovh.1	-						PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron					SubName: Full=Putative uncharacterized protein PSG6;						female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)																---	---	---	---
XRCC1	7515	broad.mit.edu	37	19	44055928	44055929	+	Intron	INS	-	AC	AC			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44055928_44055929insAC	uc002owt.2	-						XRCC1_uc010xwp.1_Intron	NM_006297	NP_006288			X-ray repair cross complementing protein 1						base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)											Other_BER_factors					---	---	---	---
XRCC1	7515	broad.mit.edu	37	19	44056299	44056300	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44056299_44056300insC	uc002owt.2	-	9	1071_1072	c.951_952insG	c.(949-954)GGGAAGfs	p.G317fs	XRCC1_uc010xwp.1_Frame_Shift_Ins_p.G286fs	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	317_318	BRCT 1.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)											Other_BER_factors					---	---	---	---
PLAUR	5329	broad.mit.edu	37	19	44173962	44173970	+	Intron	DEL	AAAAAAAAA	-	-	rs143422136		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44173962_44173970delAAAAAAAAA	uc002oxf.1	-						PLAUR_uc002oxd.1_Intron|PLAUR_uc002oxe.1_5'Flank|PLAUR_uc002oxg.1_Intron	NM_002659	NP_002650			plasminogen activator, urokinase receptor						attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)													---	---	---	---
C19orf61	56006	broad.mit.edu	37	19	44237754	44237754	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:44237754delG	uc002oxj.2	-						C19orf61_uc002oxk.2_Intron	NM_019108	NP_061981			SMG9 protein						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding				0		Prostate(69;0.0352)																---	---	---	---
BCAM	4059	broad.mit.edu	37	19	45316993	45316993	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45316993delA	uc002ozu.2	+						BCAM_uc002ozt.1_Intron	NM_005581	NP_005572			basal cell adhesion molecule isoform 1						cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)																---	---	---	---
APOC1	341	broad.mit.edu	37	19	45419666	45419666	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45419666delA	uc002pac.1	+						APOC1_uc002pad.1_Intron|APOC1_uc002pae.1_Intron|APOC1_uc002paf.1_Intron	NM_001645	NP_001636			apolipoprotein C-I precursor						cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)														---	---	---	---
RTN2	6253	broad.mit.edu	37	19	45996513	45996513	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:45996513delG	uc002pcb.2	-	5	1166	c.938delC	c.(937-939)CCTfs	p.P313fs	RTN2_uc002pcc.2_Intron|RTN2_uc002pcd.2_Intron	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	313						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)														---	---	---	---
EML2	24139	broad.mit.edu	37	19	46124695	46124695	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46124695delG	uc002pcn.2	-						EML2_uc002pco.2_Intron|EML2_uc002pcp.2_Intron|EML2_uc010xxl.1_Intron|EML2_uc010xxm.1_Intron|EML2_uc010xxn.1_Intron|EML2_uc010xxo.1_Intron|EML2_uc010ekj.2_Intron	NM_012155	NP_036287			echinoderm microtubule associated protein like						sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)														---	---	---	---
QPCTL	54814	broad.mit.edu	37	19	46204849	46204849	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46204849delA	uc010xxr.1	+						QPCTL_uc010ekn.2_Intron	NM_017659	NP_060129			glutaminyl-peptide cyclotransferase-like isoform						peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)														---	---	---	---
MYPOP	339344	broad.mit.edu	37	19	46393721	46393721	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46393721delC	uc002pdt.2	-	3						NM_001012643	NP_001012661			Myb protein P42POP							nucleus	DNA binding				0																		---	---	---	---
HIF3A	64344	broad.mit.edu	37	19	46815588	46815588	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46815588delC	uc002peh.2	+						HIF3A_uc002pef.1_Frame_Shift_Del_p.T314fs|HIF3A_uc002peg.3_Intron|HIF3A_uc010xxx.1_Intron|HIF3A_uc002pei.3_Intron|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Intron|HIF3A_uc010xxy.1_Intron|HIF3A_uc002pel.2_Intron|HIF3A_uc010xxz.1_Intron	NM_152795	NP_690008			hypoxia inducible factor 3, alpha subunit						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)														---	---	---	---
DBP	1628	broad.mit.edu	37	19	49136701	49136703	+	In_Frame_Del	DEL	CTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49136701_49136703delCTT	uc002pjx.3	-	3	1148_1150	c.760_762delAAG	c.(760-762)AAGdel	p.K254del	DBP_uc002pjy.2_3'UTR|DBP_uc010elz.1_In_Frame_Del_p.K254del	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	254					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)														---	---	---	---
TRPM4	54795	broad.mit.edu	37	19	49693455	49693455	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49693455delC	uc002pmw.2	+						TRPM4_uc010emu.2_Intron|TRPM4_uc010yak.1_Intron|TRPM4_uc002pmx.2_Intron|TRPM4_uc010emv.2_Intron|TRPM4_uc010yal.1_Intron|TRPM4_uc002pmy.2_Intron	NM_017636	NP_060106			transient receptor potential cation channel,						dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)														---	---	---	---
SLC17A7	57030	broad.mit.edu	37	19	49934715	49934716	+	Intron	INS	-	G	G	rs74182054		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49934715_49934716insG	uc002pnp.2	-						SLC17A7_uc002pno.2_Intron	NM_020309	NP_064705			solute carrier family 17, member 7						glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)														---	---	---	---
ALDH16A1	126133	broad.mit.edu	37	19	49963984	49963987	+	Intron	DEL	TTTC	-	-	rs57423257		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49963984_49963987delTTTC	uc002pnt.2	+						ALDH16A1_uc010yar.1_Intron|ALDH16A1_uc010yas.1_Intron|ALDH16A1_uc010yat.1_Intron	NM_153329	NP_699160			aldehyde dehydrogenase 16 family, member A1								oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)														---	---	---	---
SCAF1	58506	broad.mit.edu	37	19	50158042	50158042	+	Frame_Shift_Del	DEL	C	-	-	rs149487378	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50158042delC	uc002poq.2	+	9	3657	c.3533delC	c.(3532-3534)ACCfs	p.T1178fs		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1178					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)														---	---	---	---
ATF5	22809	broad.mit.edu	37	19	50434211	50434211	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50434211delC	uc010enq.1	+	3	671	c.104delC	c.(103-105)GCCfs	p.A35fs	IL4I1_uc002pqv.1_5'Flank|IL4I1_uc010eno.1_5'Flank|IL4I1_uc002pqw.1_5'Flank|IL4I1_uc002pqu.1_5'Flank|NUP62_uc002pqx.2_5'Flank|NUP62_uc002pqy.2_5'Flank|NUP62_uc002pqz.2_5'Flank|NUP62_uc002pra.2_5'Flank|NUP62_uc002prb.2_5'Flank|NUP62_uc002prc.2_5'Flank|ATF5_uc002prd.2_Frame_Shift_Del_p.A35fs	NM_012068	NP_036200	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	35					regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			skin(2)	2		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)														---	---	---	---
MYBPC2	4606	broad.mit.edu	37	19	50946647	50946648	+	Intron	INS	-	GA	GA	rs147720211	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50946647_50946648insGA	uc002psf.2	+							NM_004533	NP_004524			myosin binding protein C, fast type						cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)														---	---	---	---
SIGLEC12	89858	broad.mit.edu	37	19	52002317	52002318	+	Intron	INS	-	C	C	rs4801871	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52002317_52002318insC	uc002pwx.1	-						SIGLEC12_uc002pww.1_Intron|SIGLEC12_uc010eoy.1_Intron	NM_053003	NP_443729			sialic acid binding immunoglobulin-like						cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)														---	---	---	---
ZNF480	147657	broad.mit.edu	37	19	52819262	52819262	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52819262delT	uc010ydl.1	+						ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Intron|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285			zinc finger protein 480						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)														---	---	---	---
ZNF534	147658	broad.mit.edu	37	19	52955069	52955069	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:52955069delA	uc002pzj.1	+	5					ZNF534_uc010epo.1_3'UTR|ZNF578_uc002pzm.2_5'Flank|ZNF578_uc002pzn.2_5'Flank|ZNF578_uc002pzp.3_5'Flank|ZNF578_uc002pzo.1_5'Flank|ZNF578_uc010epp.1_5'Flank					SubName: Full=Putative uncharacterized protein;						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF702P	79986	broad.mit.edu	37	19	53473884	53473885	+	RNA	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53473884_53473885insT	uc002qan.3	-	4		c.616_617insA				NR_003578				Synthetic construct DNA, clone: pF1KB9679, Homo sapiens ZNF702 gene for zinc finger protein 702, without stop codon, in Flexi system.												0																		---	---	---	---
ZNF347	84671	broad.mit.edu	37	19	53652158	53652158	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53652158delA	uc002qbb.1	-						ZNF347_uc010eql.1_Intron|ZNF347_uc002qbc.1_Intron	NM_032584	NP_115973			zinc finger protein 347						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)														---	---	---	---
Unknown	0	broad.mit.edu	37	19	53703995	53703998	+	IGR	DEL	TTTT	-	-	rs113703393		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:53703995_53703998delTTTT								ZNF665 (7376 upstream) : ZNF677 (34640 downstream)																																			---	---	---	---
LILRB1	10859	broad.mit.edu	37	19	55148334	55148334	+	3'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55148334delG	uc002qgj.2	+	16					LILRB1_uc002qgl.2_3'UTR|LILRB1_uc002qgk.2_3'UTR|LILRB1_uc002qgm.2_3'UTR|LILRB1_uc010erq.2_3'UTR|LILRB1_uc010err.2_RNA	NM_006669	NP_006660			leukocyte immunoglobulin-like receptor,						regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)											HNSCC(37;0.09)			---	---	---	---
LILRB1	10859	broad.mit.edu	37	19	55148385	55148385	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55148385delC	uc002qgj.2	+	16					LILRB1_uc002qgl.2_3'UTR|LILRB1_uc002qgk.2_3'UTR|LILRB1_uc002qgm.2_3'UTR|LILRB1_uc010erq.2_3'UTR|LILRB1_uc010err.2_RNA	NM_006669	NP_006660			leukocyte immunoglobulin-like receptor,						regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)											HNSCC(37;0.09)			---	---	---	---
KIR3DL1	3811	broad.mit.edu	37	19	55329763	55329763	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55329763delC	uc002qhk.3	+						KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Intron|KIR3DL1_uc010esf.2_Intron|KIR3DL1_uc010yfo.1_Intron|KIR3DL1_uc002qhl.3_Intron	NM_013289	NP_037421			killer cell immunoglobulin-like receptor, three						immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
KIR3DL1	3811	broad.mit.edu	37	19	55363446	55363446	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55363446delC	uc002qhl.3	+						KIR2DS4_uc002qhn.1_Intron|KIR3DL2_uc010esh.2_Intron|KIR3DL2_uc002qho.3_Intron					SubName: Full=KIR3DS1;						immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)														---	---	---	---
TNNT1	7138	broad.mit.edu	37	19	55652163	55652165	+	Intron	DEL	TAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55652163_55652165delTAA	uc002qjb.3	-						TNNT1_uc002qiz.3_Intron|TNNT1_uc002qja.3_Intron|TNNT1_uc002qjc.3_Intron|TNNT1_uc002qje.3_Intron|TNNT1_uc002qjd.3_Intron|TNNT1_uc002qjf.2_Intron	NM_003283	NP_003274			troponin T1, skeletal, slow isoform a						muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)														---	---	---	---
C19orf51	352909	broad.mit.edu	37	19	55672059	55672059	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55672059delC	uc002qji.1	-	9	1031	c.997delG	c.(997-999)GACfs	p.D333fs	TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Frame_Shift_Del_p.D148fs|C19orf51_uc002qjj.1_Frame_Shift_Del_p.D380fs|C19orf51_uc002qjk.1_Frame_Shift_Del_p.D279fs|C19orf51_uc002qjl.1_Frame_Shift_Del_p.D401fs			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	333											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)												OREG0025678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NLRP9	338321	broad.mit.edu	37	19	56235523	56235523	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56235523delA	uc002qly.2	-							NM_176820	NP_789790			NLR family, pyrin domain containing 9							cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)														---	---	---	---
ZSCAN5A	79149	broad.mit.edu	37	19	56735214	56735214	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56735214delA	uc002qmq.2	-						ZSCAN5A_uc010ygi.1_Intron|ZSCAN5A_uc002qmr.2_Intron|ZSCAN5A_uc002qms.1_Intron	NM_024303	NP_077279			zinc finger and SCAN domain containing 5A						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
ZNF471	57573	broad.mit.edu	37	19	57029835	57029835	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57029835delT	uc002qnh.2	+							NM_020813	NP_065864			zinc finger protein 471						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)														---	---	---	---
AURKC	6795	broad.mit.edu	37	19	57745123	57745123	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57745123delT	uc002qoe.2	+						AURKC_uc002qoc.2_Intron|AURKC_uc002qod.2_Intron|AURKC_uc010etv.2_Intron	NM_001015878	NP_001015878			aurora kinase C isoform 1						cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)														---	---	---	---
PSMF1	9491	broad.mit.edu	37	20	1145691	1145691	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1145691delC	uc002wel.3	+	8	951	c.783delC	c.(781-783)CTCfs	p.L261fs	PSMF1_uc010zpo.1_Intron|PSMF1_uc002wem.3_Intron|PSMF1_uc010zpp.1_Intron|PSMF1_uc002wen.3_Frame_Shift_Del_p.L261fs|PSMF1_uc002wep.3_Frame_Shift_Del_p.L212fs	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	261	Pro-rich.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0																		---	---	---	---
PTPRA	5786	broad.mit.edu	37	20	2988207	2988207	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2988207delT	uc010zqd.1	+						PTPRA_uc002whj.2_Intron|PTPRA_uc002whk.2_Intron|PTPRA_uc002whl.2_Intron|PTPRA_uc002whm.2_Intron|PTPRA_uc002whn.2_Intron|PTPRA_uc002who.2_Intron	NM_002836	NP_002827			protein tyrosine phosphatase, receptor type, A						axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1																		---	---	---	---
C20orf194	25943	broad.mit.edu	37	20	3259599	3259599	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3259599delG	uc002wii.2	-						C20orf194_uc002wij.3_Intron|C20orf194_uc002wik.2_Intron	NM_001009984	NP_001009984			hypothetical protein LOC25943												0																		---	---	---	---
RNF24	11237	broad.mit.edu	37	20	3915839	3915839	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3915839delA	uc002wkh.2	-						RNF24_uc002wki.2_Intron|RNF24_uc002wkj.2_Intron	NM_007219	NP_009150			ring finger protein 24 isoform 1							Golgi membrane|integral to membrane	zinc ion binding				0																		---	---	---	---
SMOX	54498	broad.mit.edu	37	20	4164058	4164058	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4164058delG	uc002wkm.1	+						SMOX_uc002wkk.1_Intron|SMOX_uc002wkl.1_Intron|SMOX_uc002wkn.1_Intron|SMOX_uc002wkp.2_Intron|SMOX_uc010zqo.1_Intron|SMOX_uc002wko.1_Intron	NM_175839	NP_787033			spermine oxidase isoform 1						polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)	1					Spermine(DB00127)													---	---	---	---
TMX4	56255	broad.mit.edu	37	20	7976722	7976722	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:7976722delA	uc002wmx.1	-							NM_021156	NP_066979			thioredoxin-related transmembrane protein 4						cell redox homeostasis|electron transport chain|transport	integral to membrane					0																		---	---	---	---
SEL1L2	80343	broad.mit.edu	37	20	13936616	13936616	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:13936616delA	uc010gcf.2	-						SEL1L2_uc002woq.3_Intron|SEL1L2_uc010zrl.1_Intron|SEL1L2_uc002wor.2_Intron	NM_025229	NP_079505			sel-1 suppressor of lin-12-like 2 precursor							integral to membrane	binding			ovary(2)	2																		---	---	---	---
MACROD2	140733	broad.mit.edu	37	20	14738753	14738754	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:14738753_14738754delAA	uc002wou.2	+						MACROD2_uc002wot.2_Intron|MACROD2_uc002wox.2_Intron	NM_080676	NP_542407			MACRO domain containing 2 isoform 1												0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)																---	---	---	---
MACROD2	140733	broad.mit.edu	37	20	15843352	15843352	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:15843352delT	uc002wou.2	+						MACROD2_uc002wot.2_Intron|MACROD2_uc002woz.2_Intron|MACROD2_uc002wpb.2_Intron	NM_080676	NP_542407			MACRO domain containing 2 isoform 1												0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)																---	---	---	---
Unknown	0	broad.mit.edu	37	20	18466245	18466245	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:18466245delA								POLR3F (961 upstream) : RBBP9 (945 downstream)																																			---	---	---	---
RIN2	54453	broad.mit.edu	37	20	19956393	19956394	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:19956393_19956394insC	uc002wro.1	+	7	1760_1761	c.1724_1725insC	c.(1723-1725)GACfs	p.D575fs	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Frame_Shift_Ins_p.D369fs	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	575					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5																		---	---	---	---
RALGAPA2	57186	broad.mit.edu	37	20	20493991	20493991	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20493991delT	uc002wrz.2	-						RALGAPA2_uc010gcx.2_Intron|RALGAPA2_uc010zsg.1_Intron|RALGAPA2_uc002wsa.1_Intron	NM_020343	NP_065076			akt substrate AS250						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1																		---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21349070	21349070	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21349070delT	uc002wsf.1	+						XRN2_uc002wsg.1_Intron|XRN2_uc010zsk.1_Intron	NM_012255	NP_036387			5'-3' exoribonuclease 2						cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	30232801	30232801	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:30232801delA								COX4I2 (1 upstream) : BCL2L1 (19462 downstream)																																			---	---	---	---
BPIL1	80341	broad.mit.edu	37	20	31606796	31606796	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31606796delG	uc002wyj.2	+							NM_025227	NP_079503			bactericidal/permeability-increasing							extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4																		---	---	---	---
C20orf134	170487	broad.mit.edu	37	20	32256055	32256056	+	3'UTR	DEL	GG	-	-	rs73261831	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32256055_32256056delGG	uc002wzt.2	+	1					NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron	NM_001024675	NP_001019846			hypothetical protein LOC170487											pancreas(1)	1																OREG0025871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF341	84905	broad.mit.edu	37	20	32336673	32336674	+	Intron	DEL	CA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32336673_32336674delCA	uc002wzy.2	+						ZNF341_uc002wzx.2_Intron|ZNF341_uc010geq.2_Intron|ZNF341_uc010ger.2_Intron	NM_032819	NP_116208			zinc finger protein 341						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2																		---	---	---	---
ITCH	83737	broad.mit.edu	37	20	33064057	33064058	+	Intron	DEL	CA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33064057_33064058delCA	uc010geu.1	+						ITCH_uc002xak.2_Intron|ITCH_uc010zuj.1_Intron	NM_031483	NP_113671			itchy homolog E3 ubiquitin protein ligase						apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6																		---	---	---	---
CEP250	11190	broad.mit.edu	37	20	34096147	34096147	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34096147delT	uc002xcm.2	+						CEP250_uc010zve.1_Intron	NM_007186	NP_009117			centrosomal protein 2						centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)															---	---	---	---
Unknown	0	broad.mit.edu	37	20	34341658	34341658	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34341658delA								RBM39 (11465 upstream) : PHF20 (18265 downstream)																																			---	---	---	---
RBL1	5933	broad.mit.edu	37	20	35660979	35660979	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35660979delA	uc002xgi.2	-						RBL1_uc010zvt.1_Intron|RBL1_uc002xgj.1_Intron	NM_002895	NP_002886			retinoblastoma-like protein 1 isoform a						cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)																---	---	---	---
C20orf132	140699	broad.mit.edu	37	20	35766473	35766473	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35766473delT	uc010zvu.1	-						C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Intron|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716			hypothetical protein LOC140699 isoform 1												0		Myeloproliferative disorder(115;0.00878)																---	---	---	---
TOP1	7150	broad.mit.edu	37	20	39704579	39704579	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39704579delA	uc002xjl.2	+						TOP1_uc010gge.1_Intron	NM_003286	NP_003277			DNA topoisomerase I						DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)			T	NUP98	AML*								---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40045114	40045114	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40045114delA	uc002xka.1	-						CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597			chromodomain helicase DNA binding protein 6						chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
TP53TG5	27296	broad.mit.edu	37	20	44006414	44006415	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44006414_44006415delAA	uc002xny.2	-						SYS1-DBNDD2_uc002xnx.2_Intron	NM_014477	NP_055292			TP53-target gene 5 protein						intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)	1																		---	---	---	---
WFDC8	90199	broad.mit.edu	37	20	44184633	44184633	+	Intron	DEL	A	-	-	rs78363134		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44184633delA	uc002xow.2	-						WFDC8_uc002xox.2_Intron	NM_181510	NP_852611			WAP four-disulfide core domain 8 precursor							extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)																---	---	---	---
Unknown	0	broad.mit.edu	37	20	44236557	44236557	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44236557delA								WFDC8 (28592 upstream) : WFDC9 (22 downstream)																																			---	---	---	---
EYA2	2139	broad.mit.edu	37	20	45789429	45789429	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:45789429delT	uc002xsm.2	+						EYA2_uc010ghp.2_Intron|EYA2_uc002xsn.2_Intron|EYA2_uc002xso.2_Intron|EYA2_uc002xsp.2_Intron|EYA2_uc002xsq.2_Intron	NM_005244	NP_005235			eyes absent 2 isoform a						DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)																---	---	---	---
CSE1L	1434	broad.mit.edu	37	20	47689085	47689086	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47689085_47689086insT	uc002xty.2	+						CSE1L_uc010zyg.1_Intron|CSE1L_uc010ghx.2_Intron|CSE1L_uc010ghy.2_Intron|CSE1L_uc010zyh.1_5'Flank	NM_001316	NP_001307			CSE1 chromosome segregation 1-like protein						apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)															---	---	---	---
STAU1	6780	broad.mit.edu	37	20	47752299	47752299	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47752299delA	uc002xud.2	-						STAU1_uc002xua.2_Intron|STAU1_uc002xub.2_Intron|STAU1_uc002xuc.2_Intron|STAU1_uc002xue.2_Intron|STAU1_uc002xuf.2_Intron|STAU1_uc002xug.2_Intron	NM_017453	NP_059347			staufen isoform b							microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)															---	---	---	---
B4GALT5	9334	broad.mit.edu	37	20	48252783	48252783	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48252783delA	uc002xuu.3	-	9						NM_004776	NP_004767			UDP-Gal:betaGlcNAc beta 1,4-						post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)															---	---	---	---
TMEM189	387521	broad.mit.edu	37	20	48741400	48741403	+	3'UTR	DEL	AAAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48741400_48741403delAAAA	uc002xvg.2	-	6					TMEM189-UBE2V1_uc002xvf.2_Intron|TMEM189_uc010zyq.1_RNA|TMEM189_uc010gif.2_3'UTR|TMEM189_uc010zyp.1_3'UTR	NM_199129	NP_954580			transmembrane protein 189 isoform 1							endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)															---	---	---	---
ATP9A	10079	broad.mit.edu	37	20	50312634	50312634	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50312634delT	uc002xwg.1	-	6	545	c.545delA	c.(544-546)AACfs	p.N182fs	ATP9A_uc010gih.1_Intron|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	182	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4																		---	---	---	---
ZFP64	55734	broad.mit.edu	37	20	50776520	50776520	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:50776520delA	uc002xwl.2	-						ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Intron|ZFP64_uc002xwn.2_Intron	NM_018197	NP_060667			zinc finger protein 64 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	20	55177183	55177184	+	IGR	DEL	TG	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55177183_55177184delTG								C20orf107 (65609 upstream) : TFAP2C (27174 downstream)																																			---	---	---	---
SPO11	23626	broad.mit.edu	37	20	55906733	55906733	+	Intron	DEL	T	-	-	rs67108426		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:55906733delT	uc002xye.2	+						SPO11_uc002xyf.2_Intron	NM_012444	NP_036576			meiotic recombination protein SPO11 isoform a						female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)										Editing_and_processing_nucleases					---	---	---	---
GNAS	2778	broad.mit.edu	37	20	57415732	57415732	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57415732delG	uc002xzt.2	+	1	938	c.571delG	c.(571-573)GGGfs	p.G191fs	GNASAS_uc002xzs.1_Intron|GNAS_uc002xzu.3_5'Flank|GNAS_uc010gjq.2_5'Flank	NM_016592	NP_057676	P63092	GNAS2_HUMAN	GNAS complex locus NESP55	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)					Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			---	---	---	---
SLMO2	51012	broad.mit.edu	37	20	57611829	57611830	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57611829_57611830delAA	uc002yam.2	-						SLMO2_uc010zzv.1_Intron	NM_016045	NP_057129			slowmo homolog 2											skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
SLMO2	51012	broad.mit.edu	37	20	57613413	57613413	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57613413delA	uc002yam.2	-						SLMO2_uc010zzv.1_Intron	NM_016045	NP_057129			slowmo homolog 2											skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)															---	---	---	---
ZNF831	128611	broad.mit.edu	37	20	57828923	57828923	+	Intron	DEL	A	-	-	rs68185615		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57828923delA	uc002yan.2	+							NM_178457	NP_848552			zinc finger protein 831							intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)																	---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58455531	58455531	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58455531delA	uc002yaz.2	-							NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
SYCP2	10388	broad.mit.edu	37	20	58457237	58457237	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:58457237delA	uc002yaz.2	-							NM_014258	NP_055073			synaptonemal complex protein 2						cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)															---	---	---	---
TAF4	6874	broad.mit.edu	37	20	60587663	60587666	+	Intron	DEL	AAAG	-	-	rs6142920	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60587663_60587666delAAAG	uc002ybs.2	-							NM_003185	NP_003176			TBP-associated factor 4						interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)															---	---	---	---
DIDO1	11083	broad.mit.edu	37	20	61511207	61511207	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61511207delG	uc002ydr.1	-	16	6365	c.6101delC	c.(6100-6102)CCGfs	p.P2034fs	DIDO1_uc002yds.1_Frame_Shift_Del_p.P2034fs	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	2034	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)																	---	---	---	---
COL20A1	57642	broad.mit.edu	37	20	61943276	61943277	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61943276_61943277insC	uc011aau.1	+	14	1772_1773	c.1672_1673insC	c.(1672-1674)GCCfs	p.A558fs	COL20A1_uc011aav.1_Frame_Shift_Ins_p.A379fs	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	558	Fibronectin type-III 4.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)																	---	---	---	---
PTK6	5753	broad.mit.edu	37	20	62161351	62161351	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62161351delC	uc002yfg.2	-						PTK6_uc011aay.1_Intron|PTK6_uc011aaz.1_3'UTR	NM_005975	NP_005966			PTK6 protein tyrosine kinase 6							cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)															---	---	---	---
TPTE	7179	broad.mit.edu	37	21	10969551	10969551	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:10969551delA	uc002yip.1	-						TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870			transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)														---	---	---	---
SAMSN1	64092	broad.mit.edu	37	21	15858445	15858446	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:15858445_15858446insA	uc002yju.1	-						SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Intron	NM_022136	NP_071419			SAM domain, SH3 domain and nuclear localization						negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17203605	17203606	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17203605_17203606delAA	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17238573	17238573	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17238573delT	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
USP25	29761	broad.mit.edu	37	21	17250089	17250089	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:17250089delT	uc002yjy.1	+						USP25_uc011aby.1_Intron|USP25_uc002yjz.1_Intron|USP25_uc010gla.1_Intron	NM_013396	NP_037528			ubiquitin specific peptidase 25						protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)														---	---	---	---
Unknown	0	broad.mit.edu	37	21	21112407	21112408	+	IGR	DEL	GA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:21112407_21112408delGA								None (None upstream) : None (None downstream)																																			---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22782867	22782868	+	Intron	DEL	AT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22782867_22782868delAT	uc002yld.1	+						NCAM2_uc011acb.1_Intron	NM_004540	NP_004531			neural cell adhesion molecule 2 precursor						neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30319939	30319939	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30319939delA	uc002ymr.2	-							NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
RNF160	26046	broad.mit.edu	37	21	30357249	30357249	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30357249delA	uc002ymr.2	-						RNF160_uc010gll.1_Intron	NM_015565	NP_056380			zinc finger protein 294								ligase activity|zinc ion binding				0																		---	---	---	---
BACH1	571	broad.mit.edu	37	21	30693493	30693493	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:30693493delT	uc002ynj.2	+						BACH1_uc002ynk.2_Intron|BACH1_uc002ynl.2_Intron	NM_001186	NP_001177			BTB and CNC homology 1 transcription factor							nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|liver(1)	2																		---	---	---	---
GCFC1	94104	broad.mit.edu	37	21	34133202	34133205	+	Intron	DEL	GTGC	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34133202_34133205delGTGC	uc002yqn.2	-						GCFC1_uc002yqo.2_Intron|GCFC1_uc002yqp.2_Intron|GCFC1_uc002yqr.2_Intron	NM_016631	NP_057715			GC-rich sequence DNA-binding factor candidate							cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2																		---	---	---	---
DONSON	29980	broad.mit.edu	37	21	34947889	34947889	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34947889delT	uc002ysi.1	-	9					SON_uc002ysd.2_Intron|SON_uc002yse.1_Intron|SON_uc002ysf.1_Intron|SON_uc002ysh.2_Intron	NM_017613	NP_060083			downstream neighbor of SON						multicellular organismal development	nucleus				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
ITSN1	6453	broad.mit.edu	37	21	35183100	35183100	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:35183100delT	uc002yta.1	+						DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_Intron|ITSN1_uc002ysz.2_Intron|ITSN1_uc010gmg.2_Intron|ITSN1_uc010gmh.2_Intron|ITSN1_uc002ysw.2_Intron|ITSN1_uc010gmi.2_Intron|ITSN1_uc010gmj.2_Intron|ITSN1_uc002ysy.2_Intron|ITSN1_uc002ysx.2_Intron|ITSN1_uc002ytb.1_Intron|ITSN1_uc002ytc.1_Intron|ITSN1_uc002ytd.2_Intron|ITSN1_uc010gmk.2_Intron|ITSN1_uc010gml.2_Intron|ITSN1_uc002ytj.2_Intron|ITSN1_uc010gmm.1_Intron|ITSN1_uc002yte.2_Intron|ITSN1_uc002ytf.1_Intron	NM_003024	NP_003015			intersectin 1 isoform ITSN-l						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4																		---	---	---	---
ATP5O	539	broad.mit.edu	37	21	35284708	35284708	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:35284708delA	uc002ytl.2	-						DONSON_uc002ysn.1_5'Flank|ATP5O_uc002ytm.1_Intron	NM_001697	NP_001688			mitochondrial ATP synthase, O subunit precursor						ATP catabolic process|mitochondrial ATP synthesis coupled proton transport|respiratory electron transport chain	mitochondrial proton-transporting ATP synthase complex|plasma membrane|proton-transporting ATP synthase complex, catalytic core F(1)	drug binding|hydrogen ion transporting ATP synthase activity, rotational mechanism			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	21	37388733	37388733	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37388733delT								RUNX1 (31686 upstream) : SETD4 (18107 downstream)																																			---	---	---	---
DOPEY2	9980	broad.mit.edu	37	21	37571346	37571346	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37571346delT	uc002yvg.2	+						DOPEY2_uc011aeb.1_Intron	NM_005128	NP_005119			pad-1-like						endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2																		---	---	---	---
CHAF1B	8208	broad.mit.edu	37	21	37775020	37775020	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37775020delA	uc002yvj.2	+							NM_005441	NP_005432			chromatin assembly factor 1 subunit B						cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			ovary(1)|skin(1)	2																		---	---	---	---
ERG	2078	broad.mit.edu	37	21	39772564	39772564	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:39772564delC	uc010gnw.2	-	8	993	c.698delG	c.(697-699)GGTfs	p.G233fs	ERG_uc002yxa.2_Frame_Shift_Del_p.G226fs|ERG_uc011aek.1_Frame_Shift_Del_p.G134fs|ERG_uc010gnv.2_Intron|ERG_uc010gnx.2_Intron|ERG_uc011ael.1_Frame_Shift_Del_p.G233fs|ERG_uc002yxb.2_Intron|ERG_uc011aem.1_Intron|ERG_uc002yxc.3_Frame_Shift_Del_p.G233fs|ERG_uc010gny.1_Intron	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	233					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)																---	---	---	---
ETS2	2114	broad.mit.edu	37	21	40182050	40182050	+	Intron	DEL	T	-	-	rs72063257		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40182050delT	uc002yxg.2	+						ETS2_uc002yxf.2_Intron	NM_005239	NP_005230			v-ets erythroblastosis virus E26 oncogene						positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)																---	---	---	---
BRWD1	54014	broad.mit.edu	37	21	40570895	40570896	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40570895_40570896insT	uc002yxk.1	-	40	5585_5586	c.5446_5447insA	c.(5446-5448)ACCfs	p.T1816fs	BRWD1_uc010goc.1_Frame_Shift_Ins_p.T459fs|BRWD1_uc002yxl.2_Frame_Shift_Ins_p.T1816fs	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1816					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)																---	---	---	---
BRWD1	54014	broad.mit.edu	37	21	40584804	40584804	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40584804delA	uc002yxk.1	-						BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Intron|BRWD1_uc010god.1_Intron	NM_018963	NP_061836			bromodomain and WD repeat domain containing 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)																---	---	---	---
PRDM15	63977	broad.mit.edu	37	21	43223282	43223282	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43223282delA	uc002yzq.1	-						PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398			PR domain containing 15 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
CBS	875	broad.mit.edu	37	21	44476001	44476001	+	Intron	DEL	T	-	-	rs79861734		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:44476001delT	uc002zcu.2	-						CBS_uc002zcs.1_Intron|CBS_uc002zct.2_Intron|CBS_uc002zcw.3_Intron|CBS_uc002zcv.2_Intron|CBS_uc002zcx.2_3'UTR	NM_000071	NP_000062			cystathionine-beta-synthase						cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)													---	---	---	---
PFKL	5211	broad.mit.edu	37	21	45738491	45738491	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45738491delC	uc002zel.2	+						PFKL_uc002zek.2_Intron|PFKL_uc002zem.2_5'Flank|PFKL_uc002zen.2_5'Flank	NM_002626	NP_002617			liver phosphofructokinase						fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)														---	---	---	---
KRTAP10-9	386676	broad.mit.edu	37	21	46047173	46047173	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46047173delC	uc002zfp.3	+	1	134	c.85delC	c.(85-87)CCCfs	p.P29fs	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	29	1.|25 X 5 AA repeats of C-C-X(3).					keratin filament					0																		---	---	---	---
COL18A1	80781	broad.mit.edu	37	21	46917098	46917098	+	Intron	DEL	C	-	-	rs148453450	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46917098delC	uc011afs.1	+						COL18A1_uc002zhg.2_Intron|COL18A1_uc002zhi.2_Intron	NM_130444	NP_569711			alpha 1 type XVIII collagen isoform 3 precursor						cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)														---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47821450	47821450	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47821450delT	uc002zji.3	+						PCNT_uc002zjj.2_Intron	NM_006031	NP_006022			pericentrin						cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47842092	47842092	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47842092delC	uc002zji.3	+						PCNT_uc002zjj.2_Intron	NM_006031	NP_006022			pericentrin						cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
DIP2A	23181	broad.mit.edu	37	21	47924285	47924286	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47924285_47924286insC	uc002zjo.2	+	6	850_851	c.667_668insC	c.(667-669)GCCfs	p.A223fs	DIP2A_uc011afy.1_Frame_Shift_Ins_p.A159fs|DIP2A_uc011afz.1_Frame_Shift_Ins_p.A223fs|DIP2A_uc002zjl.2_Frame_Shift_Ins_p.A223fs|DIP2A_uc002zjm.2_Frame_Shift_Ins_p.A223fs|DIP2A_uc010gql.2_Intron|DIP2A_uc002zjn.2_Frame_Shift_Ins_p.A223fs|DIP2A_uc002zjp.1_5'UTR	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	223					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)														---	---	---	---
Unknown	0	broad.mit.edu	37	22	16419352	16419352	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:16419352delT								POTEH (131415 upstream) : OR11H1 (29474 downstream)																																			---	---	---	---
MED15	51586	broad.mit.edu	37	22	20936976	20936976	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20936976delC	uc002zsp.2	+	10	1431	c.1351delC	c.(1351-1353)CCCfs	p.P451fs	MED15_uc002zsq.2_Frame_Shift_Del_p.P411fs|MED15_uc010gso.2_Frame_Shift_Del_p.P394fs|MED15_uc002zsr.2_Frame_Shift_Del_p.P385fs|MED15_uc011ahs.1_Frame_Shift_Del_p.P385fs|MED15_uc002zss.2_Frame_Shift_Del_p.P330fs|MED15_uc011ahu.1_Frame_Shift_Del_p.P161fs|MED15_uc002zst.2_Frame_Shift_Del_p.P67fs|MED15_uc002zsu.2_Frame_Shift_Del_p.P56fs	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	451	Pro-rich.|Poly-Pro.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)															---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21152729	21152729	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21152729delT	uc002zsz.3	-							NM_058004	NP_477352			phosphatidylinositol 4-kinase type 3 alpha						phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
BCR	613	broad.mit.edu	37	22	23540414	23540414	+	Intron	DEL	T	-	-	rs2071431	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23540414delT	uc002zww.2	+						BCR_uc002zwx.2_Intron	NM_004327	NP_004318			breakpoint cluster region isoform 1						regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12								T	ABL1| FGFR1|JAK2 	CML|ALL|AML								---	---	---	---
Unknown	0	broad.mit.edu	37	22	23701945	23701945	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:23701945delA								BCR (41722 upstream) : ZDHHC8P1 (30848 downstream)																																			---	---	---	---
SEZ6L	23544	broad.mit.edu	37	22	26709567	26709570	+	Intron	DEL	CACG	-	-	rs56086023		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26709567_26709570delCACG	uc003acb.2	+						SEZ6L_uc003acc.2_Intron|SEZ6L_uc011akc.1_Intron|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Intron|SEZ6L_uc003ace.2_Intron|SEZ6L_uc003acf.1_Intron|SEZ6L_uc010gvc.1_Intron	NM_021115	NP_066938			seizure related 6 homolog (mouse)-like							endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6																		---	---	---	---
MN1	4330	broad.mit.edu	37	22	28193255	28193255	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:28193255delC	uc003adj.2	-	1	4232	c.3277delG	c.(3277-3279)GAAfs	p.E1093fs		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1093							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10								T	ETV6	AML|meningioma								---	---	---	---
SFI1	9814	broad.mit.edu	37	22	31998190	31998190	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:31998190delT	uc003ale.2	+						SFI1_uc003ald.1_Intron|SFI1_uc003alf.2_Intron|SFI1_uc003alg.2_Intron|SFI1_uc011alp.1_Intron|SFI1_uc011alq.1_Intron|SFI1_uc003alh.2_Intron|SFI1_uc010gwi.2_Intron	NM_001007467	NP_001007468			spindle assembly associated Sfi1 homolog isoform						G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1																		---	---	---	---
HMGXB4	10042	broad.mit.edu	37	22	35659263	35659263	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:35659263delT	uc003anl.2	+						HMGXB4_uc011amh.1_Intron|HMGXB4_uc003ank.2_Intron	NM_001003681	NP_001003681			high-mobility group protein 2-like 1						endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2																		---	---	---	---
SH3BP1	23616	broad.mit.edu	37	22	38042889	38042890	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38042889_38042890insC	uc003ati.2	+	11	1100_1101	c.989_990insC	c.(988-990)GACfs	p.D330fs	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_Frame_Shift_Ins_p.D330fs|SH3BP1_uc003ath.1_Frame_Shift_Ins_p.D330fs|SH3BP1_uc003atj.1_Frame_Shift_Ins_p.D266fs|SH3BP1_uc003atk.1_Frame_Shift_Ins_p.D244fs|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	330	Rho-GAP.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)																	---	---	---	---
SOX10	6663	broad.mit.edu	37	22	38370355	38370355	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38370355delT	uc003aun.1	-						POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Intron	NM_006941	NP_008872			SRY (sex determining region Y)-box 10							cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)																	---	---	---	---
DMC1	11144	broad.mit.edu	37	22	38934200	38934201	+	Intron	INS	-	A	A	rs66487664		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38934200_38934201insA	uc003avz.1	-						DMC1_uc011anv.1_Intron	NM_007068	NP_008999			DMC1 dosage suppressor of mck1 homolog						reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)												Homologous_recombination					---	---	---	---
CBY1	25776	broad.mit.edu	37	22	39069286	39069286	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39069286delT	uc003awb.2	+	6					CBY1_uc003awc.2_3'UTR|uc003awd.2_Intron	NM_001002880	NP_001002880			PKD2 interactor, golgi and endoplasmic reticulum						cardiac muscle cell differentiation|fat cell differentiation|negative regulation of transcription, DNA-dependent|protein localization	nuclear speck|trans-Golgi network	beta-catenin binding|identical protein binding			ovary(1)	1	Melanoma(58;0.04)																	---	---	---	---
GTPBP1	9567	broad.mit.edu	37	22	39123429	39123429	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39123429delC	uc003awg.2	+							NM_004286	NP_004277			GTP binding protein 1						immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)																	---	---	---	---
TNRC6B	23112	broad.mit.edu	37	22	40574036	40574037	+	5'UTR	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40574036_40574037insA	uc011aor.1	+	1					TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_5'UTR	NM_001162501	NP_001155973			trinucleotide repeat containing 6B isoform 1						gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0																		---	---	---	---
MKL1	57591	broad.mit.edu	37	22	40813065	40813067	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40813065_40813067delAAA	uc003ayv.1	-						MKL1_uc003ayw.1_Intron|MKL1_uc010gye.1_Intron|MKL1_uc010gyf.1_Intron	NM_020831	NP_065882			megakaryoblastic leukemia 1 protein						positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5								T	RBM15	acute megakaryocytic leukemia								---	---	---	---
SLC25A17	10478	broad.mit.edu	37	22	41190622	41190622	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41190622delA	uc003azc.2	-						SLC25A17_uc010gyg.2_Intron|SLC25A17_uc011aou.1_Intron|SLC25A17_uc003azd.2_Intron|SLC25A17_uc011aov.1_Intron	NM_006358	NP_006349			solute carrier family 25 (mitochondrial carrier;						fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding				0																		---	---	---	---
XPNPEP3	63929	broad.mit.edu	37	22	41264850	41264850	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41264850delA	uc003azh.2	+						XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_Intron|XPNPEP3_uc010gyh.1_Intron	NM_022098	NP_071381			X-prolyl aminopeptidase (aminopeptidase P) 3,						cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity				0																		---	---	---	---
EP300	2033	broad.mit.edu	37	22	41489174	41489174	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41489174delT	uc003azl.3	+							NM_001429	NP_001420			E1A binding protein p300						apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64								T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				---	---	---	---
PPPDE2	27351	broad.mit.edu	37	22	42000255	42000262	+	Intron	DEL	TTTTTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42000255_42000262delTTTTTTTT	uc003ban.1	-						PPPDE2_uc011apb.1_Intron	NM_015704	NP_056519			PPPDE peptidase domain containing 2												0																		---	---	---	---
NHP2L1	4809	broad.mit.edu	37	22	42076082	42076082	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42076082delA	uc003bat.2	-						NHP2L1_uc003bau.2_Intron|NHP2L1_uc003bav.2_Intron|NHP2L1_uc003baw.2_Intron	NM_005008	NP_004999			NHP2 non-histone chromosome protein 2-like 1						nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding				0																		---	---	---	---
CCDC134	79879	broad.mit.edu	37	22	42221850	42221850	+	3'UTR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42221850delG	uc003bbh.1	+	7					WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CCDC134_uc011apg.1_3'UTR|uc011aph.1_5'Flank	NM_024821	NP_079097			coiled-coil domain containing 134 precursor							extracellular region				ovary(2)	2																		---	---	---	---
WBP2NL	164684	broad.mit.edu	37	22	42415833	42415833	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42415833delT	uc011ape.1	+						WBP2NL_uc003bbt.2_Intron|WBP2NL_uc011apk.1_Intron|WBP2NL_uc003bbu.2_Intron|WBP2NL_uc003bbv.1_Intron	NM_152613	NP_689826			WBP2 N-terminal like						egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			ovary(2)	2																		---	---	---	---
TCF20	6942	broad.mit.edu	37	22	42611474	42611474	+	5'Flank	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42611474delT	uc003bcj.1	-						TCF20_uc003bck.1_5'Flank|TCF20_uc003bnt.2_5'Flank	NM_005650	NP_005641			transcription factor 20 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	22	43181118	43181119	+	IGR	INS	-	GA	GA			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:43181118_43181119insGA								A4GALT (63832 upstream) : ARFGAP3 (11413 downstream)																																			---	---	---	---
C22orf9	23313	broad.mit.edu	37	22	45595893	45595893	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45595893delG	uc003bfx.1	-	8	942	c.876delC	c.(874-876)CCCfs	p.P292fs	C22orf9_uc010gzw.1_Frame_Shift_Del_p.P144fs|C22orf9_uc003bfv.1_Frame_Shift_Del_p.P301fs|C22orf9_uc003bfw.1_Frame_Shift_Del_p.P297fs|C22orf9_uc010gzx.2_Frame_Shift_Del_p.P274fs	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	292							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)														---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46759223	46759223	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46759223delG	uc003bhw.1	-							NM_014246	NP_055061			cadherin EGF LAG seven-pass G-type receptor 1						central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
TBC1D22A	25771	broad.mit.edu	37	22	47287138	47287139	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:47287138_47287139insT	uc003bib.2	+						TBC1D22A_uc010haf.2_Intron|TBC1D22A_uc003bic.2_Intron|TBC1D22A_uc003bie.2_Intron|TBC1D22A_uc003bid.2_Intron|TBC1D22A_uc010hag.2_Intron|TBC1D22A_uc003bif.2_Intron	NM_014346	NP_055161			TBC1 domain family, member 22A							intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)														---	---	---	---
BRD1	23774	broad.mit.edu	37	22	50169305	50169306	+	Frame_Shift_Ins	INS	-	C	C	rs145188239		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50169305_50169306insC	uc003biv.2	-	11	3413_3414	c.2926_2927insG	c.(2926-2928)GAGfs	p.E976fs	BRD1_uc011arf.1_Frame_Shift_Ins_p.E702fs|BRD1_uc011arg.1_Frame_Shift_Ins_p.E1025fs|BRD1_uc011arh.1_Frame_Shift_Ins_p.E976fs|BRD1_uc003biu.3_Frame_Shift_Ins_p.E1107fs	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	976	PWWP.				histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
BRD1	23774	broad.mit.edu	37	22	50192336	50192337	+	Splice_Site	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50192336_50192337insG	uc003biv.2	-	4	2144	c.1657_splice	c.e4-1	p.V553_splice	BRD1_uc011arf.1_Splice_Site_p.V148_splice|BRD1_uc011arg.1_Splice_Site_p.V607_splice|BRD1_uc011arh.1_Splice_Site_p.V553_splice|BRD1_uc003biu.3_Splice_Site_p.V553_splice	NM_014577	NP_055392			bromodomain containing protein 1						histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)														---	---	---	---
CD99	4267	broad.mit.edu	37	X	2658621	2658621	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:2658621delT	uc004cqm.2	+						CD99_uc010nda.2_Intron|CD99_uc004cqn.2_Intron|CD99_uc004cqo.2_Intron	NM_002414	NP_002405			CD99 antigen isoform a precursor						cell adhesion	cytoplasm|integral to plasma membrane				skin(1)	1																		---	---	---	---
FAM9A	171482	broad.mit.edu	37	X	8764320	8764320	+	Frame_Shift_Del	DEL	T	-	-	rs1985393		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:8764320delT	uc004csg.2	-	6	588	c.477delA	c.(475-477)AAAfs	p.K159fs		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	159						nucleolus					0		Hepatocellular(5;0.219)																---	---	---	---
ARHGAP6	395	broad.mit.edu	37	X	11243974	11243974	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11243974delT	uc004cup.1	-						ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cum.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc010neb.1_Intron|ARHGAP6_uc011mif.1_Intron	NM_013427	NP_038286			Rho GTPase activating protein 6 isoform 1						actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2																		---	---	---	---
MSL3	10943	broad.mit.edu	37	X	11793085	11793085	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:11793085delT	uc004cuw.2	+						MSL3_uc004cux.2_Intron|MSL3_uc011mig.1_Intron|MSL3_uc011mih.1_Intron|MSL3_uc004cuy.2_Intron	NM_078629	NP_523353			male-specific lethal 3-like 1 isoform a						histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
CTPS2	56474	broad.mit.edu	37	X	16688837	16688837	+	Intron	DEL	T	-	-	rs72340997		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16688837delT	uc004cxk.2	-						CTPS2_uc004cxl.2_Intron|CTPS2_uc004cxm.2_Intron	NM_001144002	NP_001137474			cytidine triphosphate synthase II						glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)																	---	---	---	---
RBBP7	5931	broad.mit.edu	37	X	16867569	16867569	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16867569delT	uc004cxt.2	-						RBBP7_uc004cxs.1_Intron|RBBP7_uc004cxu.2_Intron	NM_002893	NP_002884			retinoblastoma binding protein 7						cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)																	---	---	---	---
RBBP7	5931	broad.mit.edu	37	X	16871713	16871714	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:16871713_16871714delAA	uc004cxt.2	-						RBBP7_uc004cxs.1_Intron|RBBP7_uc004cxu.2_Intron|RBBP7_uc010nez.2_3'UTR	NM_002893	NP_002884			retinoblastoma binding protein 7						cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18275161	18275161	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18275161delA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron|SCML2_uc010nfc.2_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
SCML2	10389	broad.mit.edu	37	X	18343207	18343209	+	Intron	DEL	AAA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18343207_18343209delAAA	uc004cyl.2	-						SCML2_uc004cyk.3_Intron|SCML2_uc010nfd.1_Intron|SCML2_uc011miz.1_Intron	NM_006089	NP_006080			sex comb on midleg-like 2						anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)																	---	---	---	---
CDKL5	6792	broad.mit.edu	37	X	18665265	18665265	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18665265delT	uc004cym.2	+						CDKL5_uc004cyn.2_Intron|RS1_uc004cyo.2_Intron	NM_003159	NP_003150			cyclin-dependent kinase-like 5						neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)																	---	---	---	---
SMS	6611	broad.mit.edu	37	X	21989957	21989957	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:21989957delT	uc004dag.2	+						SMS_uc011mjq.1_Intron|SMS_uc004daf.1_Intron	NM_004595	NP_004586			spermine synthase						methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)													---	---	---	---
Unknown	0	broad.mit.edu	37	X	24383621	24383621	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24383621delT								FAM48B1 (81 upstream) : PDK3 (99723 downstream)																																			---	---	---	---
POLA1	5422	broad.mit.edu	37	X	24742415	24742415	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:24742415delT	uc004dbl.2	+						POLA1_uc004dbm.2_Intron|POLA1_uc004dbn.2_Intron	NM_016937	NP_058633			DNA-directed DNA polymerase alpha 1						cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)													---	---	---	---
Unknown	0	broad.mit.edu	37	X	26523591	26523591	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:26523591delA								MAGEB6 (309829 upstream) : VENTXP1 (52863 downstream)																																			---	---	---	---
Unknown	0	broad.mit.edu	37	X	27537904	27537904	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:27537904delT								SMEK3P (56446 upstream) : DCAF8L2 (227022 downstream)																																			---	---	---	---
DMD	1756	broad.mit.edu	37	X	32366648	32366648	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:32366648delA	uc004dda.1	-						DMD_uc004dcw.2_Intron|DMD_uc004dcx.2_Intron|DMD_uc004dcz.2_Intron|DMD_uc004dcy.1_Intron|DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_Intron	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
DMD	1756	broad.mit.edu	37	X	33229458	33229458	+	5'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:33229458delA	uc004dda.1	-	1					DMD_uc004ddb.1_Intron|DMD_uc010ngo.1_5'UTR|DMD_uc004ddf.2_Intron|DMD_uc010ngr.1_5'UTR	NM_004006	NP_003997			dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)																---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39930432	39930432	+	Intron	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39930432delG	uc004den.3	-						BCOR_uc004dep.3_Intron|BCOR_uc004deo.3_Intron|BCOR_uc004dem.3_Intron	NM_001123385	NP_001116857			BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
BCOR	54880	broad.mit.edu	37	X	39930433	39930434	+	Intron	DEL	GA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:39930433_39930434delGA	uc004den.3	-						BCOR_uc004dep.3_Intron|BCOR_uc004deo.3_Intron|BCOR_uc004dem.3_Intron	NM_001123385	NP_001116857			BCL-6 interacting corepressor isoform c						heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4																		---	---	---	---
MED14	9282	broad.mit.edu	37	X	40588551	40588551	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:40588551delT	uc004dex.3	-						MED14_uc010nhe.1_Intron	NM_004229	NP_004220			mediator complex subunit 14						androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	41182355	41182355	+	IGR	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:41182355delG								USP9X (86525 upstream) : DDX3X (10296 downstream)																																			---	---	---	---
EFHC2	80258	broad.mit.edu	37	X	44101570	44101570	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44101570delT	uc004dgb.3	-							NM_025184	NP_079460			EF-hand domain (C-terminal) containing 2								calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6																		---	---	---	---
KDM6A	7403	broad.mit.edu	37	X	44938317	44938317	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:44938317delA	uc004dge.3	+						KDM6A_uc010nhk.2_Intron|KDM6A_uc011mkz.1_Intron|KDM6A_uc011mla.1_Intron|KDM6A_uc011mlb.1_Intron|KDM6A_uc011mlc.1_Intron|KDM6A_uc011mld.1_Intron	NM_021140	NP_066963			ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84								D|N|F|S		renal|oesophageal SCC|MM								---	---	---	---
CFP	5199	broad.mit.edu	37	X	47483960	47483960	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47483960delT	uc004dig.3	-						CFP_uc004dih.2_Intron|CFP_uc004dii.1_3'UTR|CFP_uc010nhu.2_3'UTR	NM_001145252	NP_001138724			complement factor properdin precursor						complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3																		---	---	---	---
WDR13	64743	broad.mit.edu	37	X	48462533	48462534	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48462533_48462534delAA	uc004dkh.1	+						WDR13_uc004dki.1_Intron|WDR13_uc004dkj.1_Intron|WDR13_uc004dkk.1_Intron|WDR13_uc004dkl.3_Intron	NM_017883	NP_060353			WD repeat domain 13 protein							cytoplasm|nucleus				ovary(2)	2																		---	---	---	---
OTUD5	55593	broad.mit.edu	37	X	48791593	48791597	+	Intron	DEL	TTTTT	-	-	rs10715761		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48791593_48791597delTTTTT	uc004dlu.2	-						OTUD5_uc004dlt.3_Intron|OTUD5_uc004dlv.2_Intron|OTUD5_uc011mmp.1_Intron	NM_017602	NP_060072			OTU domain containing 5 isoform a						negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1																		---	---	---	---
DGKK	139189	broad.mit.edu	37	X	50127637	50127637	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:50127637delA	uc010njr.1	-							NM_001013742	NP_001013764			diacylglycerol kinase kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)																	---	---	---	---
SSX8	280659	broad.mit.edu	37	X	52654537	52654538	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:52654537_52654538delTT	uc011moa.1	+						SSX8_uc011mob.1_Intron					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	53852846	53852847	+	IGR	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:53852846_53852847delAA								HUWE1 (139173 upstream) : PHF8 (110267 downstream)																																			---	---	---	---
WNK3	65267	broad.mit.edu	37	X	54321334	54321334	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:54321334delT	uc004dtd.1	-						WNK3_uc004dtc.1_Intron	NM_001002838	NP_001002838			WNK lysine deficient protein kinase 3 isoform 2						intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11																		---	---	---	---
ZXDA	7789	broad.mit.edu	37	X	57936402	57936403	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:57936402_57936403insG	uc004dve.2	-	1	665_666	c.452_453insC	c.(451-453)CCGfs	p.P151fs		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	151					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1																		---	---	---	---
KIF4A	24137	broad.mit.edu	37	X	69623948	69623948	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69623948delA	uc004dyg.2	+						KIF4A_uc010nkw.2_Intron	NM_012310	NP_036442			kinesin family member 4						anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4																		---	---	---	---
TEX11	56159	broad.mit.edu	37	X	69960654	69960654	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:69960654delA	uc004dyl.2	-						TEX11_uc004dym.2_Intron	NM_001003811	NP_001003811			testis expressed sequence 11 isoform 1								protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)																	---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70627378	70627378	+	Intron	DEL	T	-	-	rs78058922		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70627378delT	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
TAF1	6872	broad.mit.edu	37	X	70643961	70643962	+	Intron	INS	-	TG	TG			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70643961_70643962insTG	uc004dzu.3	+						BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Intron|TAF1_uc004dzv.3_Intron|TAF1_uc010nld.1_Intron|TAF1_uc010nle.1_Intron|TAF1_uc010nlf.1_Intron|TAF1_uc004dzx.2_Intron|TAF1_uc004dzy.2_Intron|TAF1_uc004dzw.1_Intron	NM_138923	NP_620278			TBP-associated factor 1 isoform 2						G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)																---	---	---	---
PIN4	5303	broad.mit.edu	37	X	71416535	71416535	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:71416535delT	uc004eam.2	+						PIN4_uc004eao.1_Intron	NM_006223	NP_006214			protein (peptidyl-prolyl cis/trans isomerase)						protein folding|rRNA processing	cytoplasm|mitochondrial matrix|mitochondrial matrix|nucleolus|nucleolus|preribosome|spindle|spindle	bent DNA binding|DNA binding|double-stranded DNA binding|peptidyl-prolyl cis-trans isomerase activity				0	Renal(35;0.156)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	73629971	73629971	+	IGR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:73629971delA								ZCCHC13 (105103 upstream) : SLC16A2 (11114 downstream)																																			---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74649036	74649036	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74649036delA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
ZDHHC15	158866	broad.mit.edu	37	X	74651360	74651360	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74651360delA	uc004ecg.2	-						ZDHHC15_uc004ech.2_Intron|ZDHHC15_uc011mqo.1_Intron	NM_144969	NP_659406			zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	74964415	74964416	+	IGR	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:74964415_74964416insT								ZDHHC15 (221078 upstream) : MAGEE2 (38407 downstream)																																			---	---	---	---
ATRX	546	broad.mit.edu	37	X	76763680	76763680	+	3'UTR	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76763680delA	uc004ecp.3	-	35					ATRX_uc004ecq.3_3'UTR|ATRX_uc004eco.3_3'UTR	NM_000489	NP_000480			transcriptional regulator ATRX isoform 1						DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
ATP7A	538	broad.mit.edu	37	X	77264922	77264923	+	Intron	DEL	TT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77264922_77264923delTT	uc004ecx.3	+						ATP7A_uc004ecw.2_3'UTR	NM_000052	NP_000043			ATPase, Cu++ transporting, alpha polypeptide						ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0																		---	---	---	---
APOOL	139322	broad.mit.edu	37	X	84309335	84309335	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:84309335delT	uc004eem.2	+						APOOL_uc010nmp.2_Intron	NM_198450	NP_940852			apolipoprotein O-like precursor							extracellular region					0																		---	---	---	---
DACH2	117154	broad.mit.edu	37	X	86087096	86087097	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:86087096_86087097insT	uc004eew.2	+						DACH2_uc004eex.2_Intron|DACH2_uc010nmq.2_Intron|DACH2_uc011mra.1_Intron|DACH2_uc010nmr.2_Intron	NM_053281	NP_444511			dachshund 2 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	89544585	89544585	+	IGR	DEL	C	-	-	rs3795186	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:89544585delC								TGIF2LX (366705 upstream) : None (None downstream)																																			---	---	---	---
DIAPH2	1730	broad.mit.edu	37	X	96185697	96185698	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:96185697_96185698insT	uc004efu.3	+						DIAPH2_uc004eft.3_Intron|DIAPH2_uc004efs.2_Intron	NM_006729	NP_006720			diaphanous 2 isoform 156						cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4																		---	---	---	---
TSPAN6	7105	broad.mit.edu	37	X	99887403	99887404	+	Intron	DEL	AA	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:99887403_99887404delAA	uc004ega.1	-						TSPAN6_uc010nna.1_Intron	NM_003270	NP_003261			transmembrane 4 superfamily member 6						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1																		---	---	---	---
IL1RAPL2	26280	broad.mit.edu	37	X	103903558	103903558	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:103903558delT	uc004elz.1	+							NM_017416	NP_059112			interleukin 1 receptor accessory protein-like 2						central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3																		---	---	---	---
TEX13A	56157	broad.mit.edu	37	X	104463832	104463832	+	Frame_Shift_Del	DEL	C	-	-	rs1060551	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:104463832delC	uc004ema.2	-	5	1156	c.1044delG	c.(1042-1044)GGGfs	p.G348fs	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Frame_Shift_Del_p.G349fs	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	348						intracellular	zinc ion binding			ovary(2)	2																		---	---	---	---
NRK	203447	broad.mit.edu	37	X	105183799	105183799	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:105183799delT	uc004emd.2	+						NRK_uc010npc.1_Intron	NM_198465	NP_940867			Nik related kinase								ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14															HNSCC(51;0.14)			---	---	---	---
TBC1D8B	54885	broad.mit.edu	37	X	106108892	106108892	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:106108892delT	uc004emo.2	+						MORC4_uc004emp.3_Intron	NM_017752	NP_060222			TBC1 domain family, member 8B (with GRAM domain)							intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
ACSL4	2182	broad.mit.edu	37	X	108924111	108924111	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:108924111delT	uc004eoi.2	-						ACSL4_uc004eoj.2_Intron|ACSL4_uc004eok.2_Intron|ACSL4_uc010npp.1_Intron	NM_022977	NP_075266			acyl-CoA synthetase long-chain family member 4						fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(1)|lung(1)|ovary(1)	3					Icosapent(DB00159)|Troglitazone(DB00197)													---	---	---	---
PLS3	5358	broad.mit.edu	37	X	114881754	114881754	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:114881754delA	uc004eqd.2	+						PLS3_uc011mtf.1_Intron|PLS3_uc004eqe.2_Intron|PLS3_uc011mtg.1_Intron|PLS3_uc011mth.1_Intron|PLS3_uc011mti.1_Intron|PLS3_uc011mtj.1_Intron|PLS3_uc011mtk.1_Intron|PLS3_uc011mtl.1_Intron	NM_005032	NP_005023			plastin 3							cytoplasm	actin binding|calcium ion binding			lung(1)|breast(1)	2																		---	---	---	---
WDR44	54521	broad.mit.edu	37	X	117527388	117527389	+	Intron	INS	-	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:117527388_117527389insA	uc004eqn.2	+						WDR44_uc004eqo.2_Intron|WDR44_uc011mtr.1_Intron|WDR44_uc010nqi.2_Intron	NM_019045	NP_061918			WD repeat domain 44 protein							cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5																		---	---	---	---
LONRF3	79836	broad.mit.edu	37	X	118140362	118140368	+	Intron	DEL	TTTTTTT	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118140362_118140368delTTTTTTT	uc004eqw.2	+						LONRF3_uc004eqx.2_Intron|LONRF3_uc004eqy.2_Intron|LONRF3_uc004eqz.2_Intron	NM_001031855	NP_001027026			LON peptidase N-terminal domain and ring finger						proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2																		---	---	---	---
SLC25A5	292	broad.mit.edu	37	X	118604202	118604202	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118604202delT	uc004erh.3	+						LOC100303728_uc004ere.1_5'Flank|LOC100303728_uc004erg.1_5'Flank	NM_001152	NP_001143			adenine nucleotide translocator 2						chromosome segregation|energy reserve metabolic process|interspecies interaction between organisms|regulation of insulin secretion|viral reproduction	integral to plasma membrane|mitochondrial inner membrane|mitochondrial nucleoid|MMXD complex	adenine transmembrane transporter activity|protein binding			ovary(1)	1					Clodronate(DB00720)													---	---	---	---
UPF3B	65109	broad.mit.edu	37	X	118974711	118974711	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:118974711delA	uc004erz.1	-						UPF3B_uc004esa.1_Intron	NM_080632	NP_542199			UPF3 regulator of nonsense transcripts homolog B						mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3																		---	---	---	---
ODZ1	10178	broad.mit.edu	37	X	123838709	123838709	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:123838709delA	uc004euj.2	-						ODZ1_uc011muj.1_Intron|ODZ1_uc010nqy.2_Intron	NM_014253	NP_055068			odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23																		---	---	---	---
ZNF280C	55609	broad.mit.edu	37	X	129362817	129362817	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:129362817delT	uc004evm.2	-						ZNF280C_uc010nrf.1_Intron	NM_017666	NP_060136			zinc finger protein 280C						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3																		---	---	---	---
ARHGAP36	158763	broad.mit.edu	37	X	130218769	130218770	+	Intron	INS	-	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:130218769_130218770insC	uc004evz.2	+						ARHGAP36_uc004ewa.2_Intron|ARHGAP36_uc004ewb.2_Intron|ARHGAP36_uc004ewc.2_Intron	NM_144967	NP_659404			hypothetical protein LOC158763 precursor						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	X	133407433	133407433	+	IGR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133407433delT								CCDC160 (27627 upstream) : PHF6 (99909 downstream)																																			---	---	---	---
PHF6	84295	broad.mit.edu	37	X	133511863	133511863	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133511863delA	uc004exj.2	+						PHF6_uc004exk.2_Intron|PHF6_uc011mvk.1_Intron|PHF6_uc004exh.2_Intron|PHF6_uc010nrr.2_Intron|PHF6_uc004exi.2_Intron	NM_001015877	NP_001015877			PHD finger protein 6 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
PHF6	84295	broad.mit.edu	37	X	133527689	133527689	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:133527689delT	uc004exj.2	+						PHF6_uc004exk.2_Intron|PHF6_uc011mvk.1_Intron|PHF6_uc004exh.2_Intron|PHF6_uc010nrr.2_Intron|PHF6_uc004exi.2_Intron	NM_001015877	NP_001015877			PHD finger protein 6 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
ZNF449	203523	broad.mit.edu	37	X	134495119	134495119	+	3'UTR	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134495119delT	uc004eys.2	+	5					ZNF449_uc004eyt.2_3'UTR|ZNF449_uc004eyu.2_3'UTR	NM_152695	NP_689908			zinc finger protein 449						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
DDX26B	203522	broad.mit.edu	37	X	134680317	134680317	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:134680317delT	uc004eyw.3	+	4	715	c.352delT	c.(352-354)TTTfs	p.F118fs		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	118	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
RBMX	27316	broad.mit.edu	37	X	135960248	135960248	+	Intron	DEL	A	-	-	rs35488933		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135960248delA	uc004fae.1	-						RBMX_uc011mwf.1_Intron|RBMX_uc004fad.1_Intron|RBMX_uc011mwg.1_Intron|RBMX_uc004faf.1_Intron|RBMX_uc010nsf.1_Intron|RBMX_uc004fag.1_Intron	NM_002139	NP_002130			RNA binding motif protein, X-linked isoform 1							catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MCF2	4168	broad.mit.edu	37	X	138697007	138697007	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:138697007delA	uc004fau.2	-						MCF2_uc004fav.2_Intron|MCF2_uc011mwl.1_Intron|MCF2_uc010nsh.1_Intron|MCF2_uc011mwm.1_Intron|MCF2_uc011mwn.1_Intron|MCF2_uc004faw.2_Intron|MCF2_uc011mwo.1_Intron	NM_005369	NP_005360			MCF.2 cell line derived transforming sequence						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
MAGEC3	139081	broad.mit.edu	37	X	140983317	140983317	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:140983317delG	uc011mwp.1	+	6	1095	c.1095delG	c.(1093-1095)GAGfs	p.E365fs	MAGEC3_uc004fbs.2_Intron|MAGEC3_uc010nsj.2_5'Flank	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	365	MAGE 1.			GLTEASPQQKKGG -> SSPLPSTLILGVP (in Ref. 3).						skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
FMR1	2332	broad.mit.edu	37	X	147007212	147007212	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147007212delT	uc010nst.2	+						FMR1_uc011mwz.1_Intron|FMR1_uc004fcj.2_Intron|FMR1_uc004fck.3_Intron|FMR1_uc004fcl.3_5'Flank	NM_002024	NP_002015			fragile X mental retardation 1						mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)													Fragile_X_syndrome				---	---	---	---
FMR1	2332	broad.mit.edu	37	X	147011446	147011446	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:147011446delT	uc010nst.2	+						FMR1_uc011mwz.1_Intron|FMR1_uc004fcj.2_Intron|FMR1_uc004fck.3_Intron|FMR1_uc004fcl.3_Intron|FMR1_uc011mxa.1_5'Flank	NM_002024	NP_002015			fragile X mental retardation 1						mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)													Fragile_X_syndrome				---	---	---	---
HSFX2	100130086	broad.mit.edu	37	X	148731302	148731302	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148731302delA	uc004fdl.2	-						HSFX1_uc004fdm.2_Intron	NM_016153	NP_057237			heat shock transcription factor family, X linked							cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
MAGEA11	4110	broad.mit.edu	37	X	148794754	148794754	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148794754delC	uc004fdq.2	+						HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Intron	NM_005366	NP_005357			melanoma antigen family A, 11 isoform a							cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150770186	150770186	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150770186delT	uc004fev.3	+							NM_173493	NP_775764			PAS domain containing 1							nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PNCK	139728	broad.mit.edu	37	X	152937973	152937973	+	Intron	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152937973delC	uc011myu.1	-						PNCK_uc011myt.1_Intron|PNCK_uc004fia.2_Intron|PNCK_uc004fhz.3_Intron|PNCK_uc010nuh.2_Intron|PNCK_uc011myv.1_Intron|PNCK_uc011myw.1_Intron	NM_001039582	NP_001034671			pregnancy upregulated non-ubiquitously expressed							cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PLXNA3	55558	broad.mit.edu	37	X	153688564	153688565	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153688564_153688565insG	uc004flm.2	+	2	214_215	c.41_42insG	c.(40-42)GTGfs	p.V14fs		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	14					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
Unknown	0	broad.mit.edu	37	X	154578864	154578866	+	Intron	DEL	TGT	-	-	rs150846040	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:154578864_154578866delTGT	uc004fng.2	-											Homo sapiens, clone IMAGE:5756137, mRNA.																														---	---	---	---
Unknown	0	broad.mit.edu	37	X	155255058	155255058	+	3'UTR	DEL	C	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:155255058delC	uc004fnx.3	+	9						NM_182905	NP_878908			WAS protein family homolog 1																														---	---	---	---
RPS4Y1	6192	broad.mit.edu	37	Y	2733023	2733023	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:2733023delT	uc004fqi.2	+							NM_001008	NP_000999			ribosomal protein S4, Y-linked 1 Y isoform						endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0																		---	---	---	---
ZFY	7544	broad.mit.edu	37	Y	2843347	2843347	+	Intron	DEL	A	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:2843347delA	uc004fqj.2	+						ZFY_uc010nwd.1_Intron|ZFY_uc011nan.1_Intron|ZFY_uc010nwe.2_Intron	NM_003411	NP_003402			zinc finger protein, Y-linked isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
USP9Y	8287	broad.mit.edu	37	Y	14851415	14851415	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:14851415delT	uc004fst.1	+						USP9Y_uc010nwu.1_Intron	NM_004654	NP_004645			ubiquitin specific protease 9, Y-linked						BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0																		---	---	---	---
DDX3Y	8653	broad.mit.edu	37	Y	15021407	15021407	+	Intron	DEL	T	-	-			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:15021407delT	uc004fsu.1	+						DDX3Y_uc010nwv.1_Intron|DDX3Y_uc011naq.1_Intron|DDX3Y_uc004fsv.2_Intron|DDX3Y_uc010nww.1_Intron|DDX3Y_uc011nar.1_Intron	NM_001122665	NP_001116137			DEAD (Asp-Glu-Ala-Asp) box polypeptide 3,							cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|RNA binding				0																		---	---	---	---
EIF1AY	9086	broad.mit.edu	37	Y	22744451	22744452	+	Intron	INS	-	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrY:22744451_22744452insT	uc004fuk.2	+						EIF1AY_uc004ful.2_Intron	NM_004681	NP_004672			eukaryotic translation initiation factor 1A, Y							cytoplasm	protein binding|translation initiation factor activity				0																		---	---	---	---
ATAD3A	55210	broad.mit.edu	37	1	1451391	1451391	+	Splice_Site	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1451391G>T	uc001afz.1	+	2	300	c.206_splice	c.e2-1	p.R69_splice	ATAD3A_uc001aga.1_Splice_Site_p.R69_splice|ATAD3A_uc001agb.1_Splice_Site	NM_018188	NP_060658			ATPase family, AAA domain containing 3A								ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)														---	---	---	---
MIB2	142678	broad.mit.edu	37	1	1559285	1559285	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1559285G>A	uc001agg.2	+	4	680	c.553G>A	c.(553-555)GCC>ACC	p.A185T	MIB2_uc001agh.2_Missense_Mutation_p.A171T|MIB2_uc001agi.2_Missense_Mutation_p.A185T|MIB2_uc001agj.2_Missense_Mutation_p.A26T|MIB2_uc001agk.2_Missense_Mutation_p.A185T|MIB2_uc001agl.1_Missense_Mutation_p.A141T|MIB2_uc001agm.2_Missense_Mutation_p.A127T|MIB2_uc010nyq.1_Missense_Mutation_p.A141T|MIB2_uc009vkh.2_Missense_Mutation_p.A26T|MIB2_uc001agn.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	185	ZZ-type.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
MIB2	142678	broad.mit.edu	37	1	1560527	1560527	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1560527C>T	uc001agg.2	+	6	984	c.857C>T	c.(856-858)GCG>GTG	p.A286V	MIB2_uc001agh.2_Missense_Mutation_p.A272V|MIB2_uc001agi.2_Missense_Mutation_p.A286V|MIB2_uc001agj.2_Missense_Mutation_p.A127V|MIB2_uc001agk.2_Intron|MIB2_uc001agl.1_Missense_Mutation_p.A242V|MIB2_uc001agm.2_Intron|MIB2_uc010nyq.1_Missense_Mutation_p.A242V|MIB2_uc009vkh.2_Missense_Mutation_p.A127V|MIB2_uc001agn.2_5'UTR	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	286					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)														---	---	---	---
CDK11B	984	broad.mit.edu	37	1	1581824	1581824	+	Intron	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1581824C>A	uc001agv.1	-						CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|CDK11B_uc010nyr.1_5'Flank	NM_033486	NP_277021			cell division cycle 2-like 1 (PITSLRE proteins)						apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1																		---	---	---	---
NADK	65220	broad.mit.edu	37	1	1685595	1685595	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:1685595C>A	uc009vkw.2	-	10	1117	c.996G>T	c.(994-996)GGG>GGT	p.G332G	NADK_uc001aic.2_Silent_p.G332G|NADK_uc001aid.3_Silent_p.G332G|NADK_uc001aie.2_Silent_p.G477G|NADK_uc010nyv.1_Silent_p.G300G|NADK_uc009vkx.1_3'UTR	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	332	Poly-Ala.				ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)														---	---	---	---
PRDM16	63976	broad.mit.edu	37	1	3328984	3328984	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3328984G>A	uc001akf.2	+	9	2303	c.2223G>A	c.(2221-2223)ACG>ACA	p.T741T	PRDM16_uc001akc.2_Silent_p.T741T|PRDM16_uc001akd.2_Silent_p.T741T|PRDM16_uc001ake.2_Silent_p.T741T|PRDM16_uc009vlh.2_Silent_p.T442T	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	741	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)				T	EVI1	MDS|AML								---	---	---	---
CCDC27	148870	broad.mit.edu	37	1	3680038	3680038	+	Nonsense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:3680038G>T	uc001akv.2	+	7	1402	c.1321G>T	c.(1321-1323)GGA>TGA	p.G441*		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	441										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)														---	---	---	---
AJAP1	55966	broad.mit.edu	37	1	4832433	4832433	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:4832433G>A	uc001alm.1	+	4	1392	c.1011G>A	c.(1009-1011)TCG>TCA	p.S337S	AJAP1_uc001aln.2_Silent_p.S337S	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	337	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)														---	---	---	---
CHD5	26038	broad.mit.edu	37	1	6191747	6191747	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6191747C>T	uc001amb.1	-	21	3306	c.3206G>A	c.(3205-3207)CGG>CAG	p.R1069Q	CHD5_uc001alz.1_5'UTR|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1069	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)														---	---	---	---
KLHL21	9903	broad.mit.edu	37	1	6659390	6659390	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:6659390C>T	uc001aoa.2	-	2	1196	c.1144G>A	c.(1144-1146)GGA>AGA	p.G382R	KLHL21_uc001anz.1_Missense_Mutation_p.G382R|KLHL21_uc009vme.2_Missense_Mutation_p.G15R	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	382	Kelch 2.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)														---	---	---	---
CAMTA1	23261	broad.mit.edu	37	1	7798362	7798362	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:7798362G>T	uc001aoi.2	+	16	4209	c.4002G>T	c.(4000-4002)CAG>CAT	p.Q1334H	CAMTA1_uc010nzv.1_Missense_Mutation_p.Q421H|CAMTA1_uc001aok.3_Missense_Mutation_p.Q377H|CAMTA1_uc001aoj.2_Missense_Mutation_p.Q290H	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1334					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)														---	---	---	---
RERE	473	broad.mit.edu	37	1	8557484	8557484	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:8557484T>C	uc001ape.2	-	10	1795	c.985A>G	c.(985-987)ATG>GTG	p.M329V	RERE_uc001apf.2_Missense_Mutation_p.M329V|RERE_uc010nzx.1_Missense_Mutation_p.M61V|RERE_uc001aph.1_Missense_Mutation_p.M329V	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	329	ELM2.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)														---	---	---	---
PIK3CD	5293	broad.mit.edu	37	1	9780197	9780197	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:9780197C>T	uc001aqb.3	+	11	1575	c.1367C>T	c.(1366-1368)ACG>ATG	p.T456M	PIK3CD_uc010oaf.1_Missense_Mutation_p.T456M|PIK3CD_uc001aqe.3_Missense_Mutation_p.T421M	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	456					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.T456T(1)		lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
CASZ1	54897	broad.mit.edu	37	1	10714031	10714031	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:10714031G>A	uc001aro.2	-	11	2403	c.2083C>T	c.(2083-2085)CGG>TGG	p.R695W	CASZ1_uc001arp.1_Missense_Mutation_p.R695W|CASZ1_uc009vmx.2_Missense_Mutation_p.R719W	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	695					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)														---	---	---	---
MTOR	2475	broad.mit.edu	37	1	11301720	11301720	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11301720C>A	uc001asd.2	-	10	1552	c.1431G>T	c.(1429-1431)CAG>CAT	p.Q477H		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	477					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29																OREG0013097	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
NPPA	4878	broad.mit.edu	37	1	11907422	11907422	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:11907422C>T	uc001ati.2	-	2	297	c.198G>A	c.(196-198)CCG>CCA	p.P66P	CLCN6_uc010oav.1_Intron|CLCN6_uc010oaw.1_Intron|CLCN6_uc010oax.1_Intron|CLCN6_uc010oay.1_Intron|CLCN6_uc010oaz.1_Intron|CLCN6_uc010oba.1_Intron	NM_006172	NP_006163	P01160	ANF_HUMAN	natriuretic peptide precursor A preproprotein	66					cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size	extracellular region	hormone activity			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF14	729528	broad.mit.edu	37	1	13669140	13669140	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13669140A>G	uc009vnw.1	-	4	1229	c.1046T>C	c.(1045-1047)CTG>CCG	p.L349P		NM_001099854	NP_001093324	Q5SWL7	PRA14_HUMAN	PRAME family member 14	349											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRAMEF18	391003	broad.mit.edu	37	1	13695905	13695905	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:13695905G>T	uc009vny.1	-	3	1107	c.1060C>A	c.(1060-1062)CTC>ATC	p.L354I		NM_001099850	NP_001093320	Q5VWM3	PRA18_HUMAN	PRAME family member 18	354											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
PRDM2	7799	broad.mit.edu	37	1	14108436	14108436	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:14108436C>T	uc001avi.2	+	8	5002	c.4146C>T	c.(4144-4146)GGC>GGT	p.G1382G	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Silent_p.G1382G|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Silent_p.G1181G|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1382	Arg/Lys-rich (basic).					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)														---	---	---	---
AGMAT	79814	broad.mit.edu	37	1	15905524	15905524	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:15905524C>T	uc001awv.1	-	4	693	c.550G>A	c.(550-552)GTG>ATG	p.V184M	DNAJC16_uc001awu.2_Intron	NM_024758	NP_079034	Q9BSE5	SPEB_HUMAN	agmatine ureohydrolase (agmatinase) precursor	184					putrescine biosynthetic process|spermidine biosynthetic process	mitochondrion	agmatinase activity|metal ion binding			skin(1)	1		Breast(348;0.000207)|Colorectal(325;0.000258)|Lung NSC(340;0.000359)|all_lung(284;0.000486)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.93e-07)|COAD - Colon adenocarcinoma(227;3.91e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000121)|KIRC - Kidney renal clear cell carcinoma(229;0.00257)|STAD - Stomach adenocarcinoma(313;0.00734)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
ARHGEF10L	55160	broad.mit.edu	37	1	17983195	17983195	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:17983195G>A	uc001ban.2	+	25	3011	c.2852G>A	c.(2851-2853)CGG>CAG	p.R951Q	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.R912Q|ARHGEF10L_uc001bao.2_Missense_Mutation_p.R912Q|ARHGEF10L_uc001bap.2_Missense_Mutation_p.R907Q|ARHGEF10L_uc001baq.2_Missense_Mutation_p.R712Q|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.R724Q|ARHGEF10L_uc001bar.2_Missense_Mutation_p.R654Q|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	951					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)														---	---	---	---
AKR7A3	22977	broad.mit.edu	37	1	19609292	19609292	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:19609292G>A	uc001bbv.1	-	7	1006	c.929C>T	c.(928-930)GCT>GTT	p.A310V		NM_012067	NP_036199	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3	310					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity				0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
TMCO4	255104	broad.mit.edu	37	1	20009857	20009857	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:20009857G>A	uc001bcn.2	-	16	1823	c.1581C>T	c.(1579-1581)GAC>GAT	p.D527D	TMCO4_uc001bcm.2_Silent_p.D358D|TMCO4_uc001bco.1_Silent_p.D527D|TMCO4_uc001bcp.1_Silent_p.D487D	NM_181719	NP_859070	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	527						integral to membrane					0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)														---	---	---	---
ALPL	249	broad.mit.edu	37	1	21902358	21902358	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21902358C>T	uc001bet.2	+	10	1387	c.1130C>T	c.(1129-1131)GCG>GTG	p.A377V	ALPL_uc010odn.1_Missense_Mutation_p.A325V|ALPL_uc010odo.1_Missense_Mutation_p.A322V|ALPL_uc010odp.1_Missense_Mutation_p.A300V|ALPL_uc001beu.3_Missense_Mutation_p.A377V	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	377					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)													---	---	---	---
RAP1GAP	5909	broad.mit.edu	37	1	21932596	21932596	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:21932596G>A	uc001bex.2	-	18	1649	c.1391C>T	c.(1390-1392)GCG>GTG	p.A464V	RAP1GAP_uc001bev.2_Missense_Mutation_p.A464V|RAP1GAP_uc001bew.2_Missense_Mutation_p.A528V|RAP1GAP_uc001bey.2_Missense_Mutation_p.A464V	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	464					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)														---	---	---	---
ZBTB40	9923	broad.mit.edu	37	1	22828943	22828943	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:22828943G>A	uc001bft.2	+						ZBTB40_uc001bfu.2_Intron|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_Intron	NM_001083621	NP_001077090			zinc finger and BTB domain containing 40						bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)														---	---	---	---
HNRNPR	10236	broad.mit.edu	37	1	23650160	23650160	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:23650160G>A	uc001bgr.3	-	6	723	c.564C>T	c.(562-564)GCC>GCT	p.A188A	HNRNPR_uc001bgp.3_Silent_p.A188A|HNRNPR_uc009vqk.2_Silent_p.A87A|HNRNPR_uc001bgs.3_Silent_p.A87A|HNRNPR_uc010odw.1_Silent_p.A150A|HNRNPR_uc010odx.1_Intron|HNRNPR_uc009vql.2_Silent_p.A49A	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	188	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)														---	---	---	---
TCEB3	6924	broad.mit.edu	37	1	24080931	24080931	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:24080931G>A	uc001bho.2	+	7	1910	c.1850G>A	c.(1849-1851)CGC>CAC	p.R617H		NM_003198	NP_003189	Q14241	ELOA1_HUMAN	elongin A	617	Activation domain (By similarity).|F-box.				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)														---	---	---	---
PAQR7	164091	broad.mit.edu	37	1	26189653	26189653	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26189653G>A	uc001bkx.2	-	2	1345	c.678C>T	c.(676-678)TTC>TTT	p.F226F		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	226	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CNKSR1	10256	broad.mit.edu	37	1	26515144	26515144	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26515144C>T	uc001bln.3	+	19	1725	c.1667C>T	c.(1666-1668)ACC>ATC	p.T556I	CNKSR1_uc001blm.3_Missense_Mutation_p.T549I|CNKSR1_uc009vsd.2_Missense_Mutation_p.T291I|CNKSR1_uc009vse.2_Missense_Mutation_p.T291I|CNKSR1_uc001blo.2_Missense_Mutation_p.T291I|CATSPER4_uc010oey.1_5'Flank|CATSPER4_uc010oez.1_5'Flank|CATSPER4_uc009vsf.2_5'Flank	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	556					Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
CATSPER4	378807	broad.mit.edu	37	1	26526468	26526468	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26526468C>T	uc010oez.1	+	7	906	c.906C>T	c.(904-906)TTC>TTT	p.F302F	CATSPER4_uc010oey.1_Silent_p.F124F|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	302	Helical; Name=Segment S6; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
AIM1L	55057	broad.mit.edu	37	1	26664036	26664036	+	Missense_Mutation	SNP	C	T	T	rs141056748	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:26664036C>T	uc001bmd.3	-	8	932	c.502G>A	c.(502-504)GGA>AGA	p.G168R	AIM1L_uc001bmf.3_Missense_Mutation_p.G59R	NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	168	Beta/gamma crystallin 'Greek key' 3.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)														---	---	---	---
PIGV	55650	broad.mit.edu	37	1	27121381	27121381	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27121381C>T	uc001bmz.2	+	3	1187	c.856C>T	c.(856-858)CGG>TGG	p.R286W	PIGV_uc001bmy.2_Missense_Mutation_p.R51W|PIGV_uc009vso.2_Missense_Mutation_p.R286W|PIGV_uc010ofg.1_Missense_Mutation_p.R51W|PIGV_uc001bna.2_Missense_Mutation_p.R286W	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	286	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)														---	---	---	---
NUDC	10726	broad.mit.edu	37	1	27267940	27267940	+	Intron	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27267940C>A	uc001bng.1	+						NUDC_uc001bnh.1_Intron|NUDC_uc009vsq.1_Intron	NM_006600	NP_006591			nuclear distribution gene C homolog						cell proliferation|cytokinesis|mitotic prometaphase|multicellular organismal development	cytosol|microtubule|nucleoplasm	protein binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;6.1e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.87e-29)|Colorectal(126;5.74e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000281)|STAD - Stomach adenocarcinoma(196;0.000604)|KIRC - Kidney renal clear cell carcinoma(1967;0.000739)|READ - Rectum adenocarcinoma(331;0.0421)														---	---	---	---
FAM46B	115572	broad.mit.edu	37	1	27332907	27332907	+	Missense_Mutation	SNP	C	T	T	rs142452050	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27332907C>T	uc010ofj.1	-	2	978	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	269										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
FGR	2268	broad.mit.edu	37	1	27941934	27941934	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:27941934C>T	uc001boj.2	-						FGR_uc001boi.2_Intron|FGR_uc001bok.2_Intron|FGR_uc001bol.2_Intron|FGR_uc001bom.2_Intron	NM_005248	NP_005239			proto-oncogene tyrosine-protein kinase FGR						platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)														---	---	---	---
SMPDL3B	27293	broad.mit.edu	37	1	28280888	28280888	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28280888C>T	uc001bpg.2	+	5	732	c.541C>T	c.(541-543)CCG>TCG	p.P181S	SMPDL3B_uc001bpf.2_Missense_Mutation_p.P181S|SMPDL3B_uc010ofq.1_5'UTR|SMPDL3B_uc010ofr.1_Missense_Mutation_p.P133S	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	181					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)														---	---	---	---
MED18	54797	broad.mit.edu	37	1	28661359	28661359	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28661359G>A	uc001bpt.3	+	3	750	c.505G>A	c.(505-507)GTG>ATG	p.V169M	MED18_uc009vtg.2_Missense_Mutation_p.V169M	NM_017638	NP_060108	Q9BUE0	MED18_HUMAN	mediator complex subunit 18	169					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	identical protein binding				0		Colorectal(325;0.000147)|Lung NSC(340;0.000818)|all_lung(284;0.000996)|Renal(390;0.00357)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0557)|Ovarian(437;0.113)		OV - Ovarian serous cystadenocarcinoma(117;2.36e-22)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0141)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
RCC1	1104	broad.mit.edu	37	1	28858344	28858344	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:28858344G>A	uc001bqg.1	+	3	188	c.103G>A	c.(103-105)GGC>AGC	p.G35S	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.G35S|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.G35S|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.G35S|RCC1_uc001bqe.1_Missense_Mutation_p.G52S|RCC1_uc001bqf.1_Missense_Mutation_p.G66S	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	35	RCC1 1.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
YTHDF2	51441	broad.mit.edu	37	1	29069012	29069012	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:29069012C>T	uc001brc.2	+	4	727	c.230C>T	c.(229-231)ACG>ATG	p.T77M	YTHDF2_uc001brd.2_Missense_Mutation_p.T74M|YTHDF2_uc010ofx.1_Missense_Mutation_p.T27M|YTHDF2_uc001bre.2_Missense_Mutation_p.T27M	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	77					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)														---	---	---	---
KPNA6	23633	broad.mit.edu	37	1	32635587	32635587	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32635587G>A	uc001bug.2	+	13	1437	c.1349G>A	c.(1348-1350)CGG>CAG	p.R450Q	KPNA6_uc001buh.2_Missense_Mutation_p.R225Q|KPNA6_uc010ogx.1_Missense_Mutation_p.R447Q|KPNA6_uc010ogy.1_Missense_Mutation_p.R455Q|KPNA6_uc009vtz.2_Missense_Mutation_p.R345Q	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	450	ARM 9.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)																---	---	---	---
HDAC1	3065	broad.mit.edu	37	1	32793260	32793260	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32793260A>G	uc001bvb.1	+	6	681	c.618A>G	c.(616-618)CCA>CCG	p.P206P	HDAC1_uc010ohd.1_Silent_p.P206P|HDAC1_uc010ohe.1_Silent_p.P143P|HDAC1_uc010ohf.1_Silent_p.P177P|HDAC1_uc001bvc.1_5'Flank	NM_004964	NP_004955	Q13547	HDAC1_HUMAN	histone deacetylase 1	206	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)	3		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)													---	---	---	---
TSSK3	81629	broad.mit.edu	37	1	32829430	32829430	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:32829430G>A	uc001bvf.2	+	2	821	c.380G>A	c.(379-381)GGC>GAC	p.G127D	uc001bve.1_5'Flank	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	127	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)																---	---	---	---
TRIM62	55223	broad.mit.edu	37	1	33612828	33612828	+	Missense_Mutation	SNP	C	T	T	rs61758110		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33612828C>T	uc001bxb.2	-	5	2016	c.1378G>A	c.(1378-1380)GCC>ACC	p.A460T		NM_018207	NP_060677	Q9BVG3	TRI62_HUMAN	tripartite motif-containing 62	460	B30.2/SPRY.					intracellular	zinc ion binding				0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
ZSCAN20	7579	broad.mit.edu	37	1	33945006	33945006	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33945006G>T	uc001bxj.3	+	2	284	c.117G>T	c.(115-117)AAG>AAT	p.K39N	ZSCAN20_uc001bxk.2_Missense_Mutation_p.K39N|ZSCAN20_uc009vui.2_Missense_Mutation_p.K39N	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	39					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)																---	---	---	---
CSMD2	114784	broad.mit.edu	37	1	33999485	33999485	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:33999485C>T	uc001bxn.1	-	62	9499	c.9470G>A	c.(9469-9471)CGT>CAT	p.R3157H	CSMD2_uc001bxm.1_Missense_Mutation_p.R3301H	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3157	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)																---	---	---	---
TEKT2	27285	broad.mit.edu	37	1	36553037	36553037	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36553037C>T	uc001bzr.2	+						TEKT2_uc001bzs.2_Intron|ADPRHL2_uc001bzt.2_5'Flank|ADPRHL2_uc001bzu.2_5'Flank	NM_014466	NP_055281			tektin 2						cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
MRPS15	64960	broad.mit.edu	37	1	36929762	36929762	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:36929762C>A	uc001cas.2	-	1	279	c.115G>T	c.(115-117)GGC>TGC	p.G39C		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	39				GGGSAKFPFNQWGLQPRSLLLQAARGYVVRKPAQSRLDDDP PPSTLLKDYQNV -> AVGAPSFLSTSGACSLEVSSSRPRA DMSSGNQPSLGWMMTHLLLRCSKTTRMS (in Ref. 2; AAG44697).	translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)																---	---	---	---
GRIK3	2899	broad.mit.edu	37	1	37307454	37307454	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:37307454C>A	uc001caz.2	-	10	1548	c.1413G>T	c.(1411-1413)AAG>AAT	p.K471N	GRIK3_uc001cba.1_Missense_Mutation_p.K471N	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	471	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)													---	---	---	---
GRIK3	2899	broad.mit.edu	37	1	37337814	37337814	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:37337814G>C	uc001caz.2	-	4	842	c.707C>G	c.(706-708)ACT>AGT	p.T236S	GRIK3_uc001cba.1_Missense_Mutation_p.T236S	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	236	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)													---	---	---	---
C1orf109	54955	broad.mit.edu	37	1	38152051	38152051	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:38152051C>T	uc001cbp.2	-	3	539	c.349G>A	c.(349-351)GCA>ACA	p.A117T	C1orf109_uc001cbn.2_5'Flank|C1orf109_uc010oig.1_Missense_Mutation_p.A180T|C1orf109_uc001cbo.2_Missense_Mutation_p.A179T|C1orf109_uc001cbq.1_Silent_p.T99T	NM_017850	NP_060320	Q9NX04	CA109_HUMAN	hypothetical protein LOC54955	117											0		Myeloproliferative disorder(586;0.0393)																---	---	---	---
MACF1	23499	broad.mit.edu	37	1	39812823	39812823	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:39812823G>A	uc010oiu.1	+	5	6207	c.6076G>A	c.(6076-6078)GCT>ACT	p.A2026T	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3591					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)															---	---	---	---
LEPRE1	64175	broad.mit.edu	37	1	43215907	43215907	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43215907G>A	uc001chv.2	-	11	1783	c.1670C>T	c.(1669-1671)ACG>ATG	p.T557M	LEPRE1_uc001chw.2_Missense_Mutation_p.T557M|LEPRE1_uc001chx.3_Missense_Mutation_p.T557M	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	557					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)													---	---	---	---
CDC20	991	broad.mit.edu	37	1	43828634	43828634	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43828634G>A	uc001cix.2	+	11	1435	c.1334G>A	c.(1333-1335)CGG>CAG	p.R445Q	CDC20_uc001ciy.2_Missense_Mutation_p.R445Q	NM_001255	NP_001246	Q12834	CDC20_HUMAN	cell division cycle 20	445	WD 7.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
KIAA0467	23334	broad.mit.edu	37	1	43895417	43895417	+	Missense_Mutation	SNP	C	T	T	rs150269825	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:43895417C>T	uc001cjk.1	+	14	1975	c.1513C>T	c.(1513-1515)CGT>TGT	p.R505C		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1404						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)																---	---	---	---
PTPRF	5792	broad.mit.edu	37	1	44071951	44071951	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44071951G>A	uc001cjr.2	+	20	3864	c.3524G>A	c.(3523-3525)CGG>CAG	p.R1175Q	PTPRF_uc001cjs.2_Missense_Mutation_p.R1166Q|PTPRF_uc001cju.2_Missense_Mutation_p.R553Q|PTPRF_uc009vwt.2_Missense_Mutation_p.R735Q|PTPRF_uc001cjv.2_Missense_Mutation_p.R635Q|PTPRF_uc001cjw.2_Missense_Mutation_p.R401Q	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1175	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)																---	---	---	---
ST3GAL3	6487	broad.mit.edu	37	1	44303915	44303915	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44303915C>T	uc001ckc.2	+	5	411	c.234C>T	c.(232-234)TAC>TAT	p.Y78Y	ST3GAL3_uc009vwu.1_RNA|ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Silent_p.Y93Y|ST3GAL3_uc001cka.2_Silent_p.Y62Y|ST3GAL3_uc001ckb.2_Silent_p.Y147Y|ST3GAL3_uc001ckd.2_Silent_p.Y132Y|ST3GAL3_uc001cke.2_Silent_p.Y62Y|ST3GAL3_uc001ckf.2_Silent_p.Y116Y|ST3GAL3_uc001ckg.2_Silent_p.Y78Y|ST3GAL3_uc001ckh.2_Silent_p.Y93Y|ST3GAL3_uc001cki.2_Silent_p.Y78Y|ST3GAL3_uc009vwv.2_Silent_p.Y78Y|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Intron|ST3GAL3_uc009vwy.2_Translation_Start_Site|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Silent_p.Y77Y|ST3GAL3_uc001ckl.2_Silent_p.Y78Y|ST3GAL3_uc009vwz.2_Translation_Start_Site|ST3GAL3_uc001ckn.2_RNA|ST3GAL3_uc001ckp.2_Silent_p.Y77Y|ST3GAL3_uc001cko.2_Silent_p.Y62Y|ST3GAL3_uc009vxa.2_Intron|ST3GAL3_uc001ckq.2_Silent_p.Y62Y|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Silent_p.Y62Y	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	78	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)																---	---	---	---
IPO13	9670	broad.mit.edu	37	1	44415209	44415209	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44415209G>A	uc001ckx.2	+	2	1000	c.205G>A	c.(205-207)GAC>AAC	p.D69N		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	69	Importin N-terminal.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)																---	---	---	---
DMAP1	55929	broad.mit.edu	37	1	44685868	44685868	+	Missense_Mutation	SNP	G	A	A	rs140268980		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:44685868G>A	uc001clq.1	+	10	1311	c.1231G>A	c.(1231-1233)GCA>ACA	p.A411T	DMAP1_uc001clr.1_Missense_Mutation_p.A411T|DMAP1_uc001cls.1_Missense_Mutation_p.A411T|DMAP1_uc010oku.1_Missense_Mutation_p.A401T	NM_001034024	NP_001029196	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	411					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding				0	Acute lymphoblastic leukemia(166;0.155)															OREG0013438	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
TESK2	10420	broad.mit.edu	37	1	45812673	45812673	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:45812673G>A	uc001cns.1	-	8	1173	c.770C>T	c.(769-771)CCG>CTG	p.P257L	TESK2_uc009vxr.1_Missense_Mutation_p.P257L|TESK2_uc010olo.1_Missense_Mutation_p.P174L|TESK2_uc009vxs.1_Missense_Mutation_p.P49L	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	257	Protein kinase.				actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)																	---	---	---	---
NRD1	4898	broad.mit.edu	37	1	52272560	52272560	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52272560G>A	uc001ctc.3	-	20	2542	c.2220C>T	c.(2218-2220)TTC>TTT	p.F740F	NRD1_uc009vzb.2_Silent_p.F435F|NRD1_uc001ctd.3_Silent_p.F672F|NRD1_uc001cte.2_Silent_p.F608F|NRD1_uc001ctf.2_Silent_p.F672F|NRD1_uc010ong.1_RNA	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	671					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
NRD1	4898	broad.mit.edu	37	1	52285521	52285521	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52285521G>A	uc001ctc.3	-	11	1768	c.1446C>T	c.(1444-1446)GGC>GGT	p.G482G	NRD1_uc009vzb.2_Silent_p.G177G|NRD1_uc001ctd.3_Silent_p.G414G|NRD1_uc001cte.2_Silent_p.G350G|NRD1_uc001ctf.2_Silent_p.G414G|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Silent_p.G282G	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	413					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0																		---	---	---	---
RAB3B	5865	broad.mit.edu	37	1	52403065	52403065	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:52403065C>T	uc001cth.2	-	3	373	c.248G>A	c.(247-249)CGG>CAG	p.R83Q		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	83					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1																		---	---	---	---
GPX7	2882	broad.mit.edu	37	1	53074105	53074105	+	3'UTR	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:53074105G>A	uc001cue.2	+	3						NM_015696	NP_056511			glutathione peroxidase 7 precursor						response to oxidative stress	extracellular region	glutathione peroxidase activity				0					Glutathione(DB00143)													---	---	---	---
C1orf175	374977	broad.mit.edu	37	1	55144535	55144535	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:55144535C>T	uc010ooe.1	+						C1orf175_uc001cxq.2_Intron|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_Intron|C1orf175_uc010ood.1_Intron|C1orf175_uc010oof.1_Intron|C1orf175_uc001cxr.1_Intron|C1orf175_uc010oog.1_Intron|C1orf175_uc010ooh.1_Intron|C1orf175_uc009vzq.1_Intron|C1orf175_uc001cxt.1_Intron	NM_001039464	NP_001034553			hypothetical protein LOC374977							integral to membrane	binding				0																		---	---	---	---
TACSTD2	4070	broad.mit.edu	37	1	59042093	59042093	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:59042093C>T	uc001cyz.3	-	1	1074	c.736G>A	c.(736-738)GTG>ATG	p.V246M		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	246	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)																	---	---	---	---
CACHD1	57685	broad.mit.edu	37	1	65145313	65145313	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:65145313G>A	uc001dbo.1	+	24	3232	c.3127G>A	c.(3127-3129)GCC>ACC	p.A1043T	CACHD1_uc001dbp.1_Missense_Mutation_p.A798T|CACHD1_uc001dbq.1_Missense_Mutation_p.A798T|CACHD1_uc010opa.1_Missense_Mutation_p.A287T	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1094	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2																		---	---	---	---
WLS	79971	broad.mit.edu	37	1	68564384	68564384	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:68564384T>G	uc001dee.2	-	12	1834	c.1563A>C	c.(1561-1563)GAA>GAC	p.E521D	uc001deb.1_RNA|uc001dec.1_RNA	NM_001002292	NP_001002292	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 2	Error:Variant_position_missing_in_Q5T9L3_after_alignment					multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0																		---	---	---	---
PTGER3	5733	broad.mit.edu	37	1	71513233	71513233	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:71513233C>T	uc001dfg.1	-	1	259	c.28G>A	c.(28-30)GAT>AAT	p.D10N	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.D10N|PTGER3_uc001dfl.1_Missense_Mutation_p.D10N|PTGER3_uc009wbm.1_Missense_Mutation_p.D10N|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.D10N|PTGER3_uc009wbn.1_Missense_Mutation_p.D10N|PTGER3_uc009wbo.2_Missense_Mutation_p.D10N|PTGER3_uc001dfo.2_Missense_Mutation_p.D10N|PTGER3_uc001dfp.1_Missense_Mutation_p.D10N|PTGER3_uc001dfq.2_Missense_Mutation_p.D10N|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	10	Extracellular (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)													---	---	---	---
TNNI3K	51086	broad.mit.edu	37	1	74954873	74954873	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:74954873G>C	uc001dgf.1	+	22	2173	c.2122G>C	c.(2122-2124)GGA>CGA	p.G708R	TNNI3K_uc001dge.1_Missense_Mutation_p.G809R	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	708	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10																		---	---	---	---
HFM1	164045	broad.mit.edu	37	1	91843980	91843980	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:91843980G>A	uc001doa.3	-	10	1316	c.1216C>T	c.(1216-1218)CGA>TGA	p.R406*	HFM1_uc010osu.1_Nonsense_Mutation_p.R85*|HFM1_uc010osv.1_Nonsense_Mutation_p.R90*|HFM1_uc001doc.1_Nonsense_Mutation_p.R406*	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	406	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)														---	---	---	---
TMEM56	148534	broad.mit.edu	37	1	95657235	95657235	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:95657235C>T	uc001drb.2	+	7	894	c.603C>T	c.(601-603)TCC>TCT	p.S201S	RWDD3_uc001drd.3_Intron|uc001dre.1_Intron|TMEM56_uc001drc.2_Silent_p.S201S	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	201	TLC.					integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)														---	---	---	---
LPPR5	163404	broad.mit.edu	37	1	99470207	99470207	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:99470207C>T	uc001dsb.2	-	1	243	c.21G>A	c.(19-21)GCG>GCA	p.A7A	uc001dsd.1_Intron|LPPR5_uc001dsc.2_Silent_p.A7A	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	7						integral to membrane	hydrolase activity				0																		---	---	---	---
HIAT1	64645	broad.mit.edu	37	1	100547609	100547609	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100547609G>A	uc001dst.2	+	12	1317	c.1317G>A	c.(1315-1317)CTG>CTA	p.L439L		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	439	Helical; Name=12; (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)														---	---	---	---
CCDC76	54482	broad.mit.edu	37	1	100606405	100606405	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:100606405C>T	uc001dsv.2	+						CCDC76_uc010ouf.1_Intron|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956			coiled-coil domain containing 76						tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)														---	---	---	---
WDR47	22911	broad.mit.edu	37	1	109553687	109553687	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:109553687A>G	uc001dwj.2	-	5	1357	c.981T>C	c.(979-981)CAT>CAC	p.H327H	WDR47_uc001dwl.2_Silent_p.H334H|WDR47_uc001dwi.2_Silent_p.H327H|WDR47_uc001dwk.2_Silent_p.H299H|WDR47_uc010ovf.1_Silent_p.H254H	NM_001142551	NP_001136023	O94967	WDR47_HUMAN	WD repeat domain 47 isoform 3	327										ovary(1)	1		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)														---	---	---	---
GPR61	83873	broad.mit.edu	37	1	110086476	110086476	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110086476C>T	uc001dxy.2	+	2	1515	c.832C>T	c.(832-834)CGG>TGG	p.R278W		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	278	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)														---	---	---	---
KCNC4	3749	broad.mit.edu	37	1	110768707	110768707	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110768707C>T	uc001dzh.2	+	3	1783	c.1726C>T	c.(1726-1728)CGC>TGC	p.R576C	KCNC4_uc009wfr.2_Missense_Mutation_p.R576C|KCNC4_uc001dzg.2_Missense_Mutation_p.R576C|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	576	Cytoplasmic (Potential).				synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)														---	---	---	---
SLC16A4	9122	broad.mit.edu	37	1	110924293	110924293	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:110924293C>T	uc001dzo.1	-	4	527	c.345G>A	c.(343-345)GTG>GTA	p.V115V	SLC16A4_uc009wfs.1_Intron|SLC16A4_uc001dzp.1_Silent_p.V115V|SLC16A4_uc010ovy.1_Silent_p.V53V|SLC16A4_uc001dzq.1_Silent_p.V53V|SLC16A4_uc010ovz.1_Intron	NM_004696	NP_004687	O15374	MOT5_HUMAN	solute carrier family 16, member 4	115	Helical; (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			ovary(3)	3		all_cancers(81;0.000476)|all_epithelial(167;0.000401)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0251)|all cancers(265;0.0766)|Epithelial(280;0.0807)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.14)	Pyruvic acid(DB00119)													---	---	---	---
OVGP1	5016	broad.mit.edu	37	1	111968072	111968072	+	Intron	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:111968072A>T	uc001eba.2	-						OVGP1_uc001eaz.2_Missense_Mutation_p.S46T|OVGP1_uc010owb.1_Intron|OVGP1_uc010owc.1_Intron	NM_002557	NP_002548			oviductal glycoprotein 1 precursor						chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)														---	---	---	---
PHTF1	10745	broad.mit.edu	37	1	114253067	114253067	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114253067G>A	uc009wgp.1	-	10	1530	c.1078C>T	c.(1078-1080)CGA>TGA	p.R360*	PHTF1_uc001edn.2_Nonsense_Mutation_p.R360*|PHTF1_uc001edm.2_Nonsense_Mutation_p.R117*|PHTF1_uc001edo.1_Nonsense_Mutation_p.R117*	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	360						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
PHTF1	10745	broad.mit.edu	37	1	114254720	114254720	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:114254720A>G	uc009wgp.1	-	8	1251	c.799T>C	c.(799-801)TTG>CTG	p.L267L	PHTF1_uc001edn.2_Silent_p.L267L|PHTF1_uc001edm.2_Silent_p.L24L|PHTF1_uc001edo.1_Silent_p.L24L	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	267						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)														---	---	---	---
TRIM33	51592	broad.mit.edu	37	1	115006998	115006998	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:115006998C>T	uc001eew.2	-	2	623	c.539G>A	c.(538-540)CGG>CAG	p.R180Q	TRIM33_uc010ows.1_5'Flank|TRIM33_uc001eex.2_Missense_Mutation_p.R180Q	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	180					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)				T	RET	papillary thyroid								---	---	---	---
CASQ2	845	broad.mit.edu	37	1	116311065	116311065	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:116311065C>T	uc001efx.3	-	1	362	c.98G>A	c.(97-99)CGA>CAA	p.R33Q	CASQ2_uc010owu.1_Missense_Mutation_p.R33Q	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	33			R -> Q (in CPVT2; reduces calcium- dependent dimerization).		heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)														---	---	---	---
TRIM45	80263	broad.mit.edu	37	1	117659307	117659307	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:117659307G>A	uc001egz.2	-	3	1871	c.1283C>T	c.(1282-1284)GCA>GTA	p.A428V	TRIM45_uc009whe.2_Missense_Mutation_p.A410V|TRIM45_uc001eha.2_Missense_Mutation_p.A324V	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	428	Filamin.					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)														---	---	---	---
NOTCH2	4853	broad.mit.edu	37	1	120462239	120462239	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:120462239G>A	uc001eik.2	-							NM_024408	NP_077719			notch 2 preproprotein						anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)				N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				---	---	---	---
PDE4DIP	9659	broad.mit.edu	37	1	144904728	144904728	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144904728T>C	uc001elw.3	-	20	2875	c.2584A>G	c.(2584-2586)ATG>GTG	p.M862V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.M928V|PDE4DIP_uc001emc.1_Missense_Mutation_p.M862V|PDE4DIP_uc001emd.1_Missense_Mutation_p.M862V|PDE4DIP_uc001emb.1_Missense_Mutation_p.M1025V|PDE4DIP_uc001eme.1_Intron|PDE4DIP_uc001emf.1_Missense_Mutation_p.M647V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	862	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)				T	PDGFRB	MPD								---	---	---	---
PDE4DIP	9659	broad.mit.edu	37	1	144915570	144915570	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:144915570G>A	uc001elw.3	-	14	2146	c.1855C>T	c.(1855-1857)CGT>TGT	p.R619C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R685C|PDE4DIP_uc001emc.1_Missense_Mutation_p.R619C|PDE4DIP_uc001emd.1_Missense_Mutation_p.R619C|PDE4DIP_uc001emb.1_Missense_Mutation_p.R782C|PDE4DIP_uc001eme.1_Missense_Mutation_p.R148C|PDE4DIP_uc001emf.1_Missense_Mutation_p.R404C	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	619	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)				T	PDGFRB	MPD								---	---	---	---
NOTCH2NL	388677	broad.mit.edu	37	1	145273222	145273222	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:145273222C>T	uc001emn.3	+	3	446	c.76C>T	c.(76-78)CGA>TGA	p.R26*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Nonsense_Mutation_p.R26*|NOTCH2NL_uc001emo.2_Nonsense_Mutation_p.R26*|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	26	EGF-like 2.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1																		---	---	---	---
BCL9	607	broad.mit.edu	37	1	147095697	147095697	+	Missense_Mutation	SNP	C	T	T	rs139858510	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:147095697C>T	uc001epq.2	+	10	3958	c.3218C>T	c.(3217-3219)CCG>CTG	p.P1073L	BCL9_uc010ozr.1_Missense_Mutation_p.P987L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1073	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)							T	IGH@|IGL@	B-ALL								---	---	---	---
TARS2	80222	broad.mit.edu	37	1	150469093	150469093	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150469093C>T	uc001euq.2	+	8	917	c.910C>T	c.(910-912)CGC>TGC	p.R304C	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Intron|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Intron	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	304					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)													---	---	---	---
ECM1	1893	broad.mit.edu	37	1	150482172	150482172	+	Nonsense_Mutation	SNP	C	T	T	rs121909115		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:150482172C>T	uc001eus.2	+	3	356	c.157C>T	c.(157-159)CGA>TGA	p.R53*	ECM1_uc010pce.1_5'UTR|ECM1_uc010pcf.1_5'UTR|ECM1_uc001eut.2_Nonsense_Mutation_p.R53*|ECM1_uc001euu.2_Nonsense_Mutation_p.R53*|ECM1_uc001euv.2_Nonsense_Mutation_p.R53*|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	53					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)															---	---	---	---
ZNF687	57592	broad.mit.edu	37	1	151263693	151263693	+	3'UTR	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151263693G>T	uc001exq.2	+	9					ZNF687_uc009wmo.2_3'UTR|ZNF687_uc009wmp.2_3'UTR	NM_020832	NP_065883			zinc finger protein 687						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
PSMB4	5692	broad.mit.edu	37	1	151374105	151374105	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:151374105A>G	uc001eyc.1	+	6	804	c.781A>G	c.(781-783)AGT>GGT	p.S261G	PSMB4_uc001eyb.1_3'UTR	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	261					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)															---	---	---	---
INTS3	65123	broad.mit.edu	37	1	153723713	153723713	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:153723713C>T	uc009wom.2	+	8	948	c.727C>T	c.(727-729)CGG>TGG	p.R243W	INTS3_uc001fct.2_Missense_Mutation_p.R243W|INTS3_uc001fcu.2_Translation_Start_Site|INTS3_uc001fcv.2_Missense_Mutation_p.R37W|INTS3_uc010peb.1_Missense_Mutation_p.R37W|INTS3_uc001fcw.2_Translation_Start_Site	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	244					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)															---	---	---	---
HCN3	57657	broad.mit.edu	37	1	155257677	155257677	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155257677G>A	uc001fjz.1	+	8	1756	c.1748G>A	c.(1747-1749)CGG>CAG	p.R583Q	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Missense_Mutation_p.R278Q	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	583	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)															---	---	---	---
PKLR	5313	broad.mit.edu	37	1	155265486	155265486	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155265486C>T	uc001fkb.3	-	3	384	c.345G>A	c.(343-345)GCG>GCA	p.A115A	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Silent_p.A84A|PKLR_uc010pga.1_Silent_p.A51A	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	115			A -> P (in PKRD; Val de Marne).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)													---	---	---	---
GON4L	54856	broad.mit.edu	37	1	155735156	155735156	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:155735156C>A	uc001flz.2	-	21	4205	c.4108G>T	c.(4108-4110)GAA>TAA	p.E1370*	GON4L_uc009wrg.1_RNA|GON4L_uc001fly.1_Nonsense_Mutation_p.E1370*|GON4L_uc009wrh.1_Nonsense_Mutation_p.E1370*|GON4L_uc001fma.1_Nonsense_Mutation_p.E1370*|GON4L_uc001fmb.3_Nonsense_Mutation_p.E566*|GON4L_uc001fmc.2_Nonsense_Mutation_p.E1370*|GON4L_uc001fmd.3_Nonsense_Mutation_p.E1370*|GON4L_uc009wri.2_Nonsense_Mutation_p.E956*	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	1370					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)																	---	---	---	---
LMNA	4000	broad.mit.edu	37	1	156106708	156106708	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156106708G>A	uc001fni.2	+						LMNA_uc001fnf.1_Intron|LMNA_uc001fng.2_Intron|LMNA_uc001fnh.2_Intron|LMNA_uc009wro.1_Intron|LMNA_uc010pgz.1_Intron|LMNA_uc001fnj.2_Intron|LMNA_uc001fnk.2_Intron|LMNA_uc009wrp.2_3'UTR|LMNA_uc010pha.1_Intron	NM_170707	NP_733821			lamin A/C isoform 1 precursor						cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)													Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				---	---	---	---
CRABP2	1382	broad.mit.edu	37	1	156675181	156675181	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:156675181G>A	uc001fpr.2	-	1	195	c.58C>T	c.(58-60)CTC>TTC	p.L20F		NM_001878	NP_001869	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	20					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			upper_aerodigestive_tract(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)													---	---	---	---
OR10R2	343406	broad.mit.edu	37	1	158450438	158450438	+	Silent	SNP	G	A	A	rs145805567		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158450438G>A	uc010pik.1	+	1	771	c.771G>A	c.(769-771)GCG>GCA	p.A257A	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	257	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)																	---	---	---	---
OR6K2	81448	broad.mit.edu	37	1	158669736	158669736	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158669736C>T	uc001fsu.1	-	1	707	c.707G>A	c.(706-708)CGC>CAC	p.R236H		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)																	---	---	---	---
MNDA	4332	broad.mit.edu	37	1	158817665	158817665	+	Missense_Mutation	SNP	C	T	T	rs139902913		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:158817665C>T	uc001fsz.1	+	6	1335	c.1135C>T	c.(1135-1137)CGC>TGC	p.R379C		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	379	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)																	---	---	---	---
ATP1A2	477	broad.mit.edu	37	1	160100380	160100380	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160100380G>A	uc001fvc.2	+	13	1952	c.1820G>A	c.(1819-1821)GGC>GAC	p.G607D	ATP1A2_uc001fvb.2_Missense_Mutation_p.G607D|ATP1A2_uc001fvd.2_Missense_Mutation_p.G343D|ATP1A2_uc009wtg.1_Missense_Mutation_p.G295D	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	607	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)															---	---	---	---
CD84	8832	broad.mit.edu	37	1	160523188	160523188	+	Missense_Mutation	SNP	C	T	T	rs144013322		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:160523188C>T	uc001fwh.3	-	4	764	c.740G>A	c.(739-741)CGT>CAT	p.R247H	CD84_uc001fwf.3_Missense_Mutation_p.R247H|CD84_uc001fwg.3_Missense_Mutation_p.R247H|CD84_uc009wtn.2_Missense_Mutation_p.R247H|CD84_uc001fwi.3_Missense_Mutation_p.R133H|CD84_uc001fwj.2_Missense_Mutation_p.R247H	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	247	Cytoplasmic (Potential).				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)															---	---	---	---
FCRLA	84824	broad.mit.edu	37	1	161681180	161681180	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:161681180G>A	uc001gbe.2	+	4	726	c.484G>A	c.(484-486)GGG>AGG	p.G162R	FCRLA_uc001gbd.2_Missense_Mutation_p.G156R|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	139	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)															---	---	---	---
NOS1AP	9722	broad.mit.edu	37	1	162335235	162335235	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162335235G>A	uc001gbv.2	+	9	1368	c.981G>A	c.(979-981)GCG>GCA	p.A327A	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Silent_p.A322A|NOS1AP_uc009wut.1_Silent_p.A32A	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	327	Potential.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)															---	---	---	---
UHMK1	127933	broad.mit.edu	37	1	162470791	162470791	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:162470791C>A	uc001gcc.1	+	3	786	c.650C>A	c.(649-651)ACA>AAA	p.T217K	UHMK1_uc001gcb.1_Missense_Mutation_p.T143K|UHMK1_uc009wuu.1_Missense_Mutation_p.T217K	NM_175866	NP_787062	Q8TAS1	UHMK1_HUMAN	kinase interacting stathmin	217	Protein kinase.				cell cycle arrest|neuron projection development|peptidyl-serine phosphorylation|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus	axon|dendrite cytoplasm|neuronal RNA granule|nucleus	protein binding|protein serine/threonine kinase activity|ribonucleoprotein binding|RNA binding				0	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)															---	---	---	---
SELL	6402	broad.mit.edu	37	1	169677835	169677835	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:169677835A>G	uc001ggk.2	-	3	393	c.195T>C	c.(193-195)GTT>GTC	p.V65V	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Silent_p.V18V|SELL_uc001ggl.1_Silent_p.V78V	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	65	C-type lectin.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)																	---	---	---	---
C1orf129	80133	broad.mit.edu	37	1	170955773	170955773	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:170955773A>G	uc001ghg.2	+	10	931	c.801A>G	c.(799-801)TCA>TCG	p.S267S	C1orf129_uc009wvy.2_Silent_p.S74S|C1orf129_uc010plz.1_Silent_p.S267S	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	267							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)																	---	---	---	---
QSOX1	5768	broad.mit.edu	37	1	180165944	180165944	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:180165944C>T	uc001gnz.2	+	12	2091	c.2016C>T	c.(2014-2016)GGC>GGT	p.G672G	QSOX1_uc001gny.2_Intron|QSOX1_uc001goa.2_Intron|QSOX1_uc001goc.2_Silent_p.G214G|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	672					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
FAM5C	339479	broad.mit.edu	37	1	190068210	190068210	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:190068210G>A	uc001gse.1	-	8	1471	c.1239C>T	c.(1237-1239)AAC>AAT	p.N413N	FAM5C_uc010pot.1_Silent_p.N311N	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	413						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)																	---	---	---	---
CACNA1S	779	broad.mit.edu	37	1	201012450	201012450	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201012450G>T	uc001gvv.2	-	40	5234	c.5007C>A	c.(5005-5007)GCC>GCA	p.A1669A		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1669	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)											OREG0014067	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
IGFN1	91156	broad.mit.edu	37	1	201196181	201196181	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:201196181G>T	uc001gwc.2	+	12	3210	c.2438G>T	c.(2437-2439)AGC>ATC	p.S813I	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3																		---	---	---	---
LGR6	59352	broad.mit.edu	37	1	202287739	202287739	+	Missense_Mutation	SNP	G	A	A	rs145532673	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:202287739G>A	uc001gxu.2	+	18	2308	c.2308G>A	c.(2308-2310)GCC>ACC	p.A770T	LGR6_uc001gxv.2_Missense_Mutation_p.A718T|LGR6_uc009xab.2_RNA|LGR6_uc001gxw.2_Missense_Mutation_p.A631T	NM_001017403	NP_001017403	Q9HBX8	LGR6_HUMAN	leucine-rich repeat-containing G protein-coupled	770	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			large_intestine(4)|ovary(3)|skin(2)|pancreas(1)	10																		---	---	---	---
MYOG	4656	broad.mit.edu	37	1	203054835	203054835	+	Silent	SNP	C	T	T	rs148417428		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:203054835C>T	uc001gzd.2	-	1	543	c.255G>A	c.(253-255)GCG>GCA	p.A85A		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	85	Basic motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2																		---	---	---	---
SOX13	9580	broad.mit.edu	37	1	204094988	204094988	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204094988C>T	uc001ham.2	+	14	2190	c.1595C>T	c.(1594-1596)CCG>CTG	p.P532L	SOX13_uc010pqp.1_Missense_Mutation_p.P531L|SOX13_uc010pqq.1_Missense_Mutation_p.P399L	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	532					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)															---	---	---	---
PLEKHA6	22874	broad.mit.edu	37	1	204218332	204218332	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:204218332G>A	uc001hau.2	-	11	1971	c.1654C>T	c.(1654-1656)CAG>TAG	p.Q552*	PLEKHA6_uc009xaw.1_Nonsense_Mutation_p.Q250*|PLEKHA6_uc009xax.1_Nonsense_Mutation_p.Q232*|PLEKHA6_uc009xay.1_Nonsense_Mutation_p.Q203*|PLEKHA6_uc009xaz.1_3'UTR|PLEKHA6_uc009xba.1_Nonsense_Mutation_p.Q223*|PLEKHA6_uc009xbb.1_Nonsense_Mutation_p.Q205*|PLEKHA6_uc009xbc.1_Nonsense_Mutation_p.Q182*	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	552										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)															---	---	---	---
DSTYK	25778	broad.mit.edu	37	1	205119923	205119923	+	Splice_Site	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205119923C>T	uc001hbw.2	-	11	2417	c.2353_splice	c.e11-1	p.L785_splice	DSTYK_uc001hbx.2_Splice_Site_p.L785_splice	NM_015375	NP_056190			receptor interacting protein kinase 5 isoform 1							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1																		---	---	---	---
TMCC2	9911	broad.mit.edu	37	1	205238117	205238117	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205238117G>A	uc001hbz.1	+	4	1231	c.787G>A	c.(787-789)GGC>AGC	p.G263S	TMCC2_uc010prf.1_Missense_Mutation_p.G185S|TMCC2_uc001hca.2_Missense_Mutation_p.G38S|TMCC2_uc001hcb.1_Missense_Mutation_p.G23S|TMCC2_uc001hcc.1_5'UTR|TMCC2_uc001hcd.2_Missense_Mutation_p.G30S	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	263						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)															---	---	---	---
MFSD4	148808	broad.mit.edu	37	1	205548987	205548987	+	Silent	SNP	G	A	A	rs150786831		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205548987G>A	uc001hcv.3	+	2	425	c.339G>A	c.(337-339)GCG>GCA	p.A113A	MFSD4_uc010prk.1_Silent_p.A113A|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Silent_p.A58A	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	113	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)															---	---	---	---
SLC26A9	115019	broad.mit.edu	37	1	205895654	205895654	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:205895654G>A	uc001hdq.2	-						SLC26A9_uc001hdo.2_Intron|SLC26A9_uc001hdp.2_Intron	NM_052934	NP_443166			solute carrier family 26, member 9 isoform a							integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)															---	---	---	---
CR1L	1379	broad.mit.edu	37	1	207818618	207818618	+	Missense_Mutation	SNP	C	T	T	rs61739989	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:207818618C>T	uc001hga.3	+	1	161	c.40C>T	c.(40-42)CGG>TGG	p.R14W	CR1L_uc001hfz.2_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	14						cytoplasm|extracellular region|membrane					0																		---	---	---	---
C1orf107	27042	broad.mit.edu	37	1	210017023	210017023	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:210017023G>A	uc001hhr.1	+	11	2085	c.2009G>A	c.(2008-2010)CGC>CAC	p.R670H	C1orf107_uc009xcu.1_Missense_Mutation_p.R385H	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	670					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)														---	---	---	---
TMEM206	55248	broad.mit.edu	37	1	212583792	212583792	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:212583792T>G	uc001hjc.3	-	2	276	c.108A>C	c.(106-108)AGA>AGC	p.R36S	TMEM206_uc010pte.1_Missense_Mutation_p.R97S	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	36	Cytoplasmic (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)														---	---	---	---
CENPF	1063	broad.mit.edu	37	1	214816309	214816309	+	Missense_Mutation	SNP	C	T	T	rs141012292	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:214816309C>T	uc001hkm.2	+	12	4802	c.4628C>T	c.(4627-4629)TCG>TTG	p.S1543L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1639					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)														---	---	---	---
ESRRG	2104	broad.mit.edu	37	1	216850658	216850658	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:216850658C>A	uc001hkw.1	-	2	398	c.232G>T	c.(232-234)GGA>TGA	p.G78*	ESRRG_uc001hky.1_Nonsense_Mutation_p.G55*|ESRRG_uc009xdp.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hkz.1_Nonsense_Mutation_p.G55*|ESRRG_uc010puc.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hla.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hlb.1_Nonsense_Mutation_p.G55*|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hld.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hkx.1_Nonsense_Mutation_p.G83*|ESRRG_uc009xdo.1_Nonsense_Mutation_p.G55*|ESRRG_uc001hle.1_Nonsense_Mutation_p.G55*	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	78					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)													---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217793655	217793655	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217793655C>T	uc001hlf.1	-	2	339	c.243G>A	c.(241-243)CCG>CCA	p.P81P	GPATCH2_uc001hlg.3_Silent_p.P81P	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	81						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
GPATCH2	55105	broad.mit.edu	37	1	217793681	217793681	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:217793681G>A	uc001hlf.1	-	2	313	c.217C>T	c.(217-219)CGG>TGG	p.R73W	GPATCH2_uc001hlg.3_Missense_Mutation_p.R73W	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	73						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)														---	---	---	---
EPRS	2058	broad.mit.edu	37	1	220208265	220208265	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220208265T>C	uc001hly.1	-	3	492	c.222A>G	c.(220-222)GAA>GAG	p.E74E	EPRS_uc010puf.1_5'UTR|EPRS_uc001hlz.1_Silent_p.E74E|EPRS_uc009xdt.1_5'UTR	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	74					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)													---	---	---	---
MOSC1	64757	broad.mit.edu	37	1	220970104	220970104	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:220970104G>A	uc001hms.2	+	3	817	c.569G>A	c.(568-570)AGA>AAA	p.R190K	MOSC1_uc001hmt.2_Missense_Mutation_p.R190K	NM_022746	NP_073583	Q5VT66	MOSC1_HUMAN	MOCO sulphurase C-terminal domain containing 1	190	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding				0				GBM - Glioblastoma multiforme(131;0.0358)														---	---	---	---
HLX	3142	broad.mit.edu	37	1	221053223	221053223	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:221053223C>A	uc001hmv.3	+	1	481	c.24C>A	c.(22-24)CCC>CCA	p.P8P		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	8					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)														---	---	---	---
SUSD4	55061	broad.mit.edu	37	1	223396923	223396923	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:223396923C>T	uc001hnx.2	-	7	1746	c.1112G>A	c.(1111-1113)GGC>GAC	p.G371D	SUSD4_uc001hny.3_Missense_Mutation_p.G371D|SUSD4_uc010puw.1_Missense_Mutation_p.G211D	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	371	Cytoplasmic (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)														---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228464338	228464338	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228464338G>A	uc009xez.1	+	22	6452	c.6408G>A	c.(6406-6408)TCG>TCA	p.S2136S	OBSCN_uc001hsn.2_Silent_p.S2136S|OBSCN_uc001hsp.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2136	Ig-like 21.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
OBSCN	84033	broad.mit.edu	37	1	228525710	228525710	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:228525710G>A	uc009xez.1	+	67	16910	c.16866G>A	c.(16864-16866)ACG>ACA	p.T5622T	OBSCN_uc001hsn.2_Silent_p.T5622T|OBSCN_uc001hsr.1_Silent_p.T250T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5622	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)																---	---	---	---
ACTA1	58	broad.mit.edu	37	1	229567731	229567731	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229567731C>T	uc001htm.2	-							NM_001100	NP_001091			actin, alpha 1, skeletal muscle						muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)													---	---	---	---
ACTA1	58	broad.mit.edu	37	1	229568322	229568322	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229568322G>A	uc001htm.2	-	3	540	c.435C>T	c.(433-435)TAC>TAT	p.Y145Y		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	145					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)													---	---	---	---
URB2	9816	broad.mit.edu	37	1	229783439	229783439	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:229783439T>C	uc001hts.1	+	7	4225	c.4089T>C	c.(4087-4089)TAT>TAC	p.Y1363Y	URB2_uc009xfd.1_Silent_p.Y1363Y	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1363						nucleolus				central_nervous_system(2)|ovary(1)	3																		---	---	---	---
CAPN9	10753	broad.mit.edu	37	1	230903329	230903329	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:230903329C>T	uc001htz.1	+	5	692	c.579C>T	c.(577-579)ATC>ATT	p.I193I	CAPN9_uc009xfg.1_Silent_p.I130I|CAPN9_uc001hua.1_Silent_p.I193I	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	193	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)																---	---	---	---
PCNXL2	80003	broad.mit.edu	37	1	233372604	233372604	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:233372604G>A	uc001hvl.2	-	9	2580	c.2345C>T	c.(2344-2346)TCG>TTG	p.S782L	PCNXL2_uc009xfu.2_RNA|PCNXL2_uc009xfv.1_RNA|PCNXL2_uc001hvq.1_Missense_Mutation_p.S81L	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	782						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)																---	---	---	---
MTR	4548	broad.mit.edu	37	1	237057711	237057711	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237057711G>A	uc001hyi.3	+	30	3682	c.3259G>A	c.(3259-3261)GCT>ACT	p.A1087T	MTR_uc010pxw.1_Missense_Mutation_p.A680T|MTR_uc010pxx.1_Missense_Mutation_p.A1036T|MTR_uc010pxy.1_Missense_Mutation_p.A941T	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1087	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)													---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237806639	237806639	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237806639G>A	uc001hyl.1	+	48	7354	c.7234G>A	c.(7234-7236)GGG>AGG	p.G2412R		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2412	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
RYR2	6262	broad.mit.edu	37	1	237947294	237947294	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:237947294C>T	uc001hyl.1	+	90	12402	c.12282C>T	c.(12280-12282)ATC>ATT	p.I4094I	RYR2_uc010pya.1_Silent_p.I509I	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4094					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.I4092I(1)		ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)															---	---	---	---
ZP4	57829	broad.mit.edu	37	1	238051712	238051712	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:238051712G>T	uc001hym.2	-	4	499	c.499C>A	c.(499-501)CTA>ATA	p.L167I	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	167	P-type.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)															---	---	---	---
EXO1	9156	broad.mit.edu	37	1	242035407	242035407	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:242035407T>C	uc001hzh.2	+	12	1881	c.1341T>C	c.(1339-1341)TCT>TCC	p.S447S	EXO1_uc001hzi.2_Silent_p.S447S|EXO1_uc001hzj.2_Silent_p.S447S|EXO1_uc009xgq.2_Silent_p.S446S	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	447	Interaction with MLH1.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)										Direct_reversal_of_damage|Editing_and_processing_nucleases					---	---	---	---
AKT3	10000	broad.mit.edu	37	1	243675724	243675724	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:243675724A>G	uc001iab.1	-	12	1337	c.1256T>C	c.(1255-1257)GTA>GCA	p.V419A	AKT3_uc001hzz.1_Missense_Mutation_p.V419A	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1	419	AGC-kinase C-terminal.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)															---	---	---	---
KIF26B	55083	broad.mit.edu	37	1	245850605	245850605	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:245850605G>A	uc001ibf.1	+	12	4760	c.4320G>A	c.(4318-4320)CCG>CCA	p.P1440P	KIF26B_uc001ibg.1_Silent_p.P1058P|KIF26B_uc001ibh.1_Silent_p.P682P	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1440					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)															---	---	---	---
CNST	163882	broad.mit.edu	37	1	246810568	246810568	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:246810568A>G	uc001ibp.2	+	9	1443	c.1065A>G	c.(1063-1065)GCA>GCG	p.A355A	CNST_uc001ibo.3_Silent_p.A355A	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	355					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0																OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF496	84838	broad.mit.edu	37	1	247464071	247464071	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr1:247464071G>A	uc001ico.2	-	9	1979	c.1514C>T	c.(1513-1515)GCG>GTG	p.A505V	ZNF496_uc009xgv.2_Missense_Mutation_p.A541V|ZNF496_uc001icp.2_Missense_Mutation_p.A505V	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	505					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)															---	---	---	---
PXDN	7837	broad.mit.edu	37	2	1652681	1652681	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:1652681C>T	uc002qxa.2	-	17	2935	c.2871G>A	c.(2869-2871)ACG>ACA	p.T957T		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	957					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)														---	---	---	---
ATP6V1C2	245973	broad.mit.edu	37	2	10863007	10863007	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:10863007G>T	uc002ras.2	+	2	141	c.32G>T	c.(31-33)GGC>GTC	p.G11V	ATP6V1C2_uc002rat.2_Missense_Mutation_p.G11V	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	11					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)														---	---	---	---
ROCK2	9475	broad.mit.edu	37	2	11356319	11356319	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11356319G>A	uc002rbd.1	-	13	1875	c.1426C>T	c.(1426-1428)CGC>TGC	p.R476C		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	476	REM.|Potential.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)														---	---	---	---
GREB1	9687	broad.mit.edu	37	2	11777862	11777862	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:11777862G>A	uc002rbk.1	+	31	5667	c.5367G>A	c.(5365-5367)GCG>GCA	p.A1789A	GREB1_uc002rbp.1_Silent_p.A787A	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1789						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)														---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15534361	15534361	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15534361T>C	uc002rcc.1	-	28	3273	c.3247A>G	c.(3247-3249)ACT>GCT	p.T1083A	NBAS_uc010exl.1_Missense_Mutation_p.T155A|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1083										ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
NBAS	51594	broad.mit.edu	37	2	15676570	15676570	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:15676570G>A	uc002rcc.1	-	8	645	c.619C>T	c.(619-621)CGA>TGA	p.R207*	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	207										ovary(2)|liver(1)|skin(1)	4																		---	---	---	---
ADCY3	109	broad.mit.edu	37	2	25047345	25047345	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25047345G>A	uc002rfs.3	-	16	2837	c.2638C>T	c.(2638-2640)CGT>TGT	p.R880C	ADCY3_uc002rfr.3_Missense_Mutation_p.R467C|ADCY3_uc010ykm.1_Missense_Mutation_p.R881C	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	880	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)																	---	---	---	---
DNMT3A	1788	broad.mit.edu	37	2	25523110	25523110	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:25523110G>A	uc002rgc.2	-	3	332	c.75C>T	c.(73-75)GAC>GAT	p.D25D	DNMT3A_uc002rgd.2_Silent_p.D25D|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rge.2_Silent_p.D22D|DNMT3A_uc002rgf.2_Silent_p.D25D	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	25					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)							Mis|F|N|S		AML								---	---	---	---
AGBL5	60509	broad.mit.edu	37	2	27275837	27275837	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27275837G>A	uc002rie.2	+	2	228	c.11G>A	c.(10-12)CGC>CAC	p.R4H	AGBL5_uc002ric.2_Missense_Mutation_p.R4H|AGBL5_uc002rid.2_Missense_Mutation_p.R4H|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	4					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
EMILIN1	11117	broad.mit.edu	37	2	27306221	27306221	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27306221C>T	uc002rii.3	+	4	2210	c.1782C>T	c.(1780-1782)CGC>CGT	p.R594R	EMILIN1_uc002rik.3_5'Flank	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	594	Potential.				cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)																	---	---	---	---
IFT172	26160	broad.mit.edu	37	2	27700448	27700448	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27700448T>C	uc002rku.2	-	12	1250	c.1199A>G	c.(1198-1200)AAG>AGG	p.K400R	IFT172_uc002rkw.2_Missense_Mutation_p.K400R|IFT172_uc010yls.1_Missense_Mutation_p.K379R|IFT172_uc010ezc.2_Missense_Mutation_p.K400R|IFT172_uc002rkv.2_Missense_Mutation_p.K374R	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	400					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
CCDC121	79635	broad.mit.edu	37	2	27850362	27850362	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27850362C>T	uc002rle.2	-	2	486	c.305G>A	c.(304-306)CGG>CAG	p.R102Q	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Missense_Mutation_p.R266Q|CCDC121_uc002rld.2_Missense_Mutation_p.R264Q|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	102											0	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
GPN1	11321	broad.mit.edu	37	2	27852006	27852006	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:27852006G>T	uc010ymc.1	+	1	144	c.123G>T	c.(121-123)ATG>ATT	p.M41I	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_5'Flank|CCDC121_uc002rld.2_5'Flank|CCDC121_uc002rle.2_5'Flank|GPN1_uc010ezf.2_Intron|GPN1_uc010yma.1_Intron|GPN1_uc010ymb.1_Intron|GPN1_uc010ymd.1_5'UTR|GPN1_uc010yme.1_Missense_Mutation_p.M41I|GPN1_uc010ezg.1_5'Flank	NM_007266	NP_009197	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1 isoform a	27	GTP (Pootential).					cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding				0																		---	---	---	---
PLB1	151056	broad.mit.edu	37	2	28739709	28739709	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:28739709T>C	uc002rmb.1	+	2	90	c.90T>C	c.(88-90)AGT>AGC	p.S30S	PLB1_uc010ezj.1_Silent_p.S30S	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	30	Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
XDH	7498	broad.mit.edu	37	2	31588866	31588866	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:31588866G>A	uc002rnv.1	-	22	2511	c.2432C>T	c.(2431-2433)ACG>ATG	p.T811M		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	811					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)													---	---	---	---
BIRC6	57448	broad.mit.edu	37	2	32740783	32740783	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:32740783G>A	uc010ezu.2	+	55	11429	c.11295G>A	c.(11293-11295)GCG>GCA	p.A3765A		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3765					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)																	---	---	---	---
HNRPLL	92906	broad.mit.edu	37	2	38800365	38800365	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:38800365C>T	uc002rqw.2	-	8	1489	c.1079G>A	c.(1078-1080)GGA>GAA	p.G360E	HNRPLL_uc002rqv.2_Missense_Mutation_p.G55E|HNRPLL_uc002rqx.2_Missense_Mutation_p.G355E	NM_138394	NP_612403	Q8WVV9	HNRLL_HUMAN	heterogeneous nuclear ribonucleoprotein L-like	360	RRM 3.				mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)																---	---	---	---
SLC8A1	6546	broad.mit.edu	37	2	40366803	40366803	+	Silent	SNP	G	A	A	rs139842575		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:40366803G>A	uc002rrx.2	-	9	2307	c.2283C>T	c.(2281-2283)GAC>GAT	p.D761D	uc002rrw.2_Intron|SLC8A1_uc002rry.2_Silent_p.D756D|SLC8A1_uc002rrz.2_Silent_p.D748D|SLC8A1_uc002rsa.2_Silent_p.D725D|SLC8A1_uc002rsd.3_Silent_p.D725D	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	761	Cytoplasmic (Potential).|Poly-Asp.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)													---	---	---	---
TTC7A	57217	broad.mit.edu	37	2	47220638	47220638	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:47220638G>A	uc002rvo.2	+	6	1182	c.814G>A	c.(814-816)GAG>AAG	p.E272K	TTC7A_uc002rvm.2_Missense_Mutation_p.E238K|TTC7A_uc002rvn.1_Missense_Mutation_p.E153K|TTC7A_uc010fbb.2_Missense_Mutation_p.E272K|TTC7A_uc010fbc.2_5'UTR|TTC7A_uc002rvp.2_Missense_Mutation_p.E153K|TTC7A_uc002rvq.2_Missense_Mutation_p.E12K|TTC7A_uc002rvr.2_5'Flank	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	272							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)															---	---	---	---
SPTBN1	6711	broad.mit.edu	37	2	54853348	54853348	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:54853348A>G	uc002rxu.2	+	12	1870	c.1621A>G	c.(1621-1623)ATG>GTG	p.M541V	SPTBN1_uc002rxv.1_Missense_Mutation_p.M541V|SPTBN1_uc002rxx.2_Missense_Mutation_p.M528V	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	541	Spectrin 3.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)															---	---	---	---
TMEM17	200728	broad.mit.edu	37	2	62733266	62733266	+	5'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:62733266C>T	uc002sbt.2	-	1					TMEM17_uc002sbu.2_5'UTR|TMEM17_uc002sbv.1_Intron	NM_198276	NP_938017			transmembrane protein 17							integral to membrane					0	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)															---	---	---	---
ALMS1	7840	broad.mit.edu	37	2	73650099	73650099	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:73650099T>C	uc002sje.1	+	5	875	c.764T>C	c.(763-765)CTG>CCG	p.L255P	ALMS1_uc002sjf.1_Missense_Mutation_p.L212P	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	254					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9																		---	---	---	---
SLC4A5	57835	broad.mit.edu	37	2	74460640	74460640	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:74460640C>T	uc002sko.1	-	18	2486	c.2484G>A	c.(2482-2484)CCG>CCA	p.P828P	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.P828P|SLC4A5_uc010ffc.1_Silent_p.P828P|SLC4A5_uc002skp.1_Silent_p.P726P|SLC4A5_uc002sks.1_Silent_p.P790P	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	828	Helical; (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9																		---	---	---	---
TCF7L1	83439	broad.mit.edu	37	2	85536360	85536360	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:85536360G>T	uc002soy.2	+	12	1616	c.1542G>T	c.(1540-1542)CAG>CAT	p.Q514H		NM_031283	NP_112573	Q9HCS4	TF7L1_HUMAN	HMG-box transcription factor TCF-3	514					chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
EIF2AK3	9451	broad.mit.edu	37	2	88876178	88876178	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:88876178C>T	uc002stc.3	-	12	2132	c.1930G>A	c.(1930-1932)GCC>ACC	p.A644T		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	644	Cytoplasmic (Potential).|Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3																		---	---	---	---
Unknown	0	broad.mit.edu	37	2	89246881	89246881	+	RNA	SNP	T	A	A	rs11546115		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:89246881T>A	uc010ytr.1	-	101		c.8178A>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																														---	---	---	---
DUSP2	1844	broad.mit.edu	37	2	96809731	96809731	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96809731G>A	uc002svk.3	-	4	862	c.776C>T	c.(775-777)GCG>GTG	p.A259V		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	259	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)																---	---	---	---
SNRNP200	23020	broad.mit.edu	37	2	96945252	96945252	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:96945252G>A	uc002svu.2	-	36	5156	c.5070C>T	c.(5068-5070)CAC>CAT	p.H1690H	SNRNP200_uc002svt.2_Silent_p.H300H|SNRNP200_uc010yuj.1_RNA	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1690	Helicase C-terminal 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10																		---	---	---	---
VWA3B	200403	broad.mit.edu	37	2	98928382	98928382	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98928382A>G	uc002syo.2	+	27	3886	c.3622A>G	c.(3622-3624)AAA>GAA	p.K1208E	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.K865E|VWA3B_uc002syp.1_Missense_Mutation_p.K600E|VWA3B_uc002syq.1_Missense_Mutation_p.K484E|VWA3B_uc002syr.1_Missense_Mutation_p.K525E|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1208										ovary(3)|large_intestine(2)|skin(1)	6																		---	---	---	---
CNGA3	1261	broad.mit.edu	37	2	98994192	98994192	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:98994192G>A	uc002syt.2	+	3	561	c.144G>A	c.(142-144)CCG>CCA	p.P48P	CNGA3_uc002syu.2_Silent_p.P48P|CNGA3_uc010fij.2_5'UTR	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	48			P -> L.		signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6																		---	---	---	---
LYG2	254773	broad.mit.edu	37	2	99870726	99870726	+	5'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:99870726C>T	uc002szw.1	-	2					MRPL30_uc002szl.1_Intron|LYG2_uc010fip.1_5'UTR|LYG2_uc002szx.1_5'UTR	NM_175735	NP_783862			lysozyme G-like 2 precursor						cell wall macromolecule catabolic process|peptidoglycan catabolic process	extracellular region	lysozyme activity			ovary(1)	1																		---	---	---	---
GPR45	11250	broad.mit.edu	37	2	105858894	105858894	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:105858894C>T	uc002tco.1	+	1	695	c.579C>T	c.(577-579)CGC>CGT	p.R193R		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	193	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3																		---	---	---	---
RANBP2	5903	broad.mit.edu	37	2	109382397	109382397	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:109382397G>A	uc002tem.3	+	20	5528	c.5402G>A	c.(5401-5403)TGT>TAT	p.C1801Y		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1801	RanBP2-type 8.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18																		---	---	---	---
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:112608394T>C	uc002thi.2	-	14	1856	c.1609A>G	c.(1609-1611)ACT>GCT	p.T537A		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2																		---	---	---	---
PSD4	23550	broad.mit.edu	37	2	113943688	113943688	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:113943688C>T	uc002tjc.2	+	5	1667	c.1484C>T	c.(1483-1485)ACG>ATG	p.T495M	PSD4_uc002tjd.2_Missense_Mutation_p.T116M|PSD4_uc002tje.2_Missense_Mutation_p.T466M|PSD4_uc002tjf.2_Missense_Mutation_p.T116M	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	495					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2																		---	---	---	---
PAX8	7849	broad.mit.edu	37	2	114002038	114002038	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:114002038T>C	uc010yxt.1	-	4	521	c.355A>G	c.(355-357)AAT>GAT	p.N119D	PAX8_uc010yxu.1_Missense_Mutation_p.N119D|PAX8_uc010yxv.1_Missense_Mutation_p.N119D|PAX8_uc002tjm.2_Missense_Mutation_p.N119D|PAX8_uc002tjn.2_Missense_Mutation_p.N119D|PAX8_uc010fku.1_Missense_Mutation_p.N119D|LOC654433_uc002tjq.3_Intron|LOC654433_uc010fks.2_Intron|LOC654433_uc010fkt.2_Intron|LOC654433_uc002tjr.3_Intron	NM_003466	NP_003457	Q06710	PAX8_HUMAN	paired box 8 isoform PAX8A	119	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity			ovary(1)|lung(1)	2								T	PPARG	follicular thyroid		Thyroid dysgenesis 						---	---	---	---
STEAP3	55240	broad.mit.edu	37	2	120020712	120020712	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:120020712G>A	uc002tlp.2	+	6	1422	c.1265G>A	c.(1264-1266)AGC>AAC	p.S422N	STEAP3_uc002tlq.2_Missense_Mutation_p.S432N|STEAP3_uc002tlr.2_Missense_Mutation_p.S422N|STEAP3_uc010fle.2_3'UTR	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	422	Vesicular (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3																		---	---	---	---
INHBB	3625	broad.mit.edu	37	2	121104166	121104166	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121104166C>T	uc002tmn.2	+	1	448	c.402C>T	c.(400-402)GCC>GCT	p.A134A		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	134					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)																---	---	---	---
INHBB	3625	broad.mit.edu	37	2	121107004	121107004	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121107004G>A	uc002tmn.2	+	2	824	c.778G>A	c.(778-780)GTG>ATG	p.V260M		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	260					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)																---	---	---	---
GLI2	2736	broad.mit.edu	37	2	121742146	121742146	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:121742146G>A	uc010flp.2	+	11	1813	c.1783G>A	c.(1783-1785)GTC>ATC	p.V595I	GLI2_uc002tmq.1_Missense_Mutation_p.V267I|GLI2_uc002tmr.1_Missense_Mutation_p.V250I|GLI2_uc002tmt.3_Missense_Mutation_p.V267I|GLI2_uc002tmu.3_Missense_Mutation_p.V250I|GLI2_uc002tmw.1_Missense_Mutation_p.V578I	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	595					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)																---	---	---	---
CLASP1	23332	broad.mit.edu	37	2	122204972	122204972	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:122204972G>A	uc002tnc.2	-	19	2243	c.1853C>T	c.(1852-1854)TCG>TTG	p.S618L	CLASP1_uc002tna.2_5'UTR|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.S618L|CLASP1_uc010yza.1_Missense_Mutation_p.S618L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.S618L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	618	Ser-rich.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)																	---	---	---	---
HS6ST1	9394	broad.mit.edu	37	2	129025854	129025854	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:129025854C>T	uc002tpt.3	-	2	1152	c.1118G>A	c.(1117-1119)AGG>AAG	p.R373K		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	373	Potential.|Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)														---	---	---	---
RAB6C	84084	broad.mit.edu	37	2	130738154	130738154	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130738154A>G	uc002tpx.1	+	1	920	c.466A>G	c.(466-468)AGG>GGG	p.R156G	uc002tpw.1_5'Flank	NM_032144	NP_115520	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	156					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			lung(1)	1	Colorectal(110;0.1)																	---	---	---	---
CCDC74B	91409	broad.mit.edu	37	2	130899770	130899770	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130899770C>T	uc002tqm.1	-	3	542	c.480G>A	c.(478-480)GTG>GTA	p.V160V	CCDC74B_uc010yzw.1_Silent_p.V262V|CCDC74B_uc002tqn.1_Intron|CCDC74B_uc010yzx.1_3'UTR	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	160											0	Colorectal(110;0.1)																	---	---	---	---
CCDC74B	91409	broad.mit.edu	37	2	130899886	130899886	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:130899886C>T	uc002tqm.1	-	3	426	c.364G>A	c.(364-366)GGA>AGA	p.G122R	CCDC74B_uc010yzw.1_Missense_Mutation_p.G224R|CCDC74B_uc002tqn.1_Intron|CCDC74B_uc010yzx.1_3'UTR	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	122											0	Colorectal(110;0.1)																	---	---	---	---
FAM123C	205147	broad.mit.edu	37	2	131520215	131520215	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131520215G>A	uc002trw.2	+	2	760	c.570G>A	c.(568-570)CCG>CCA	p.P190P	FAM123C_uc010fmv.2_Silent_p.P190P|FAM123C_uc010fms.1_Silent_p.P190P|FAM123C_uc010fmt.1_Silent_p.P190P|FAM123C_uc010fmu.1_Silent_p.P190P	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	190										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)														---	---	---	---
ARHGEF4	50649	broad.mit.edu	37	2	131803619	131803619	+	Missense_Mutation	SNP	C	T	T	rs146423704	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:131803619C>T	uc002tsa.1	+	14	2450	c.1930C>T	c.(1930-1932)CGG>TGG	p.R644W	ARHGEF4_uc010fmw.1_Missense_Mutation_p.R792W|ARHGEF4_uc002tsb.1_3'UTR|ARHGEF4_uc010fmx.1_Missense_Mutation_p.R584W|ARHGEF4_uc002tsc.1_Missense_Mutation_p.R187W	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	644					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)														---	---	---	---
CCDC74A	90557	broad.mit.edu	37	2	132288220	132288220	+	Missense_Mutation	SNP	G	A	A	rs148324548		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132288220G>A	uc002tta.2	+	3	416	c.364G>A	c.(364-366)GGA>AGA	p.G122R	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	122										skin(1)	1																		---	---	---	---
CCDC74A	90557	broad.mit.edu	37	2	132288336	132288336	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:132288336G>A	uc002tta.2	+	3	532	c.480G>A	c.(478-480)GTG>GTA	p.V160V	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	160										skin(1)	1																		---	---	---	---
LCT	3938	broad.mit.edu	37	2	136561666	136561666	+	Silent	SNP	C	A	A	rs150796821		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:136561666C>A	uc002tuu.1	-	11	4508	c.4497G>T	c.(4495-4497)ACG>ACT	p.T1499T		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1499	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)														---	---	---	---
LRP1B	53353	broad.mit.edu	37	2	141208157	141208157	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:141208157G>A	uc002tvj.1	-	63	11009	c.10037C>T	c.(10036-10038)TCT>TTT	p.S3346F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3346	Extracellular (Potential).|LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)											TSP Lung(27;0.18)			---	---	---	---
STAM2	10254	broad.mit.edu	37	2	152980308	152980308	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:152980308C>T	uc002tyc.3	-	13	1671	c.1321G>A	c.(1321-1323)GCA>ACA	p.A441T		NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	441					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)														---	---	---	---
RPRM	56475	broad.mit.edu	37	2	154334995	154334995	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:154334995A>G	uc002tyq.1	-	1	328	c.85T>C	c.(85-87)TGC>CGC	p.C29R		NM_019845	NP_062819	Q9NS64	RPRM_HUMAN	reprimo, TP53 dependant G2 arrest mediator	29					cell cycle arrest	cytoplasm|integral to membrane	protein binding				0																		---	---	---	---
TANC1	85461	broad.mit.edu	37	2	160053294	160053294	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:160053294G>A	uc002uag.2	+	18	3429	c.3155G>A	c.(3154-3156)GGC>GAC	p.G1052D	TANC1_uc010zcm.1_Missense_Mutation_p.G1044D|TANC1_uc010fom.1_Missense_Mutation_p.G858D|TANC1_uc010fon.2_5'Flank	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1052	ANK 5.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
TBR1	10716	broad.mit.edu	37	2	162275394	162275394	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:162275394G>A	uc002ubw.1	+						TBR1_uc010foy.2_Intron	NM_006593	NP_006584			T-box, brain, 1							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
LRP2	4036	broad.mit.edu	37	2	170062048	170062048	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170062048C>T	uc002ues.2	-	41	7869	c.7656G>A	c.(7654-7656)ATG>ATA	p.M2552I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2552	LDL-receptor class B 27.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)													---	---	---	---
PPIG	9360	broad.mit.edu	37	2	170493803	170493803	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:170493803G>A	uc002uez.2	+	14	2255	c.2035G>A	c.(2035-2037)GAA>AAA	p.E679K	PPIG_uc010fpx.2_Missense_Mutation_p.E664K|PPIG_uc010fpy.2_Missense_Mutation_p.E672K|PPIG_uc002ufb.2_Missense_Mutation_p.E679K|PPIG_uc002ufd.2_Missense_Mutation_p.E676K	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	679					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)													---	---	---	---
RAPGEF4	11069	broad.mit.edu	37	2	173782536	173782536	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:173782536C>T	uc002uhv.3	+	5	638	c.451C>T	c.(451-453)CGA>TGA	p.R151*	RAPGEF4_uc002uhu.2_Nonsense_Mutation_p.R151*|RAPGEF4_uc002uhw.3_Nonsense_Mutation_p.R7*|RAPGEF4_uc010zec.1_5'UTR|RAPGEF4_uc010zed.1_5'UTR|RAPGEF4_uc010zee.1_5'UTR|RAPGEF4_uc010fqo.2_5'UTR	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	151	cAMP 1.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)															---	---	---	---
EVX2	344191	broad.mit.edu	37	2	176948108	176948108	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:176948108C>T	uc010zeu.1	-	1	583	c.397G>A	c.(397-399)GCC>ACC	p.A133T		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	133						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)														---	---	---	---
TTN	7273	broad.mit.edu	37	2	179393909	179393909	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179393909T>C	uc010zfg.1	-	309	99089	c.98865A>G	c.(98863-98865)CAA>CAG	p.Q32955Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.Q26650Q|TTN_uc010zfi.1_Silent_p.Q26583Q|TTN_uc010zfj.1_Silent_p.Q26458Q|TTN_uc002umq.2_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33882							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179437710	179437710	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179437710C>T	uc010zfg.1	-	275	65669	c.65445G>A	c.(65443-65445)TCG>TCA	p.S21815S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.S15510S|TTN_uc010zfi.1_Silent_p.S15443S|TTN_uc010zfj.1_Silent_p.S15318S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22742							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179480434	179480434	+	Missense_Mutation	SNP	G	A	A	rs2303830	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179480434G>A	uc010zfg.1	-	207	40914	c.40690C>T	c.(40690-40692)CGT>TGT	p.R13564C	TTN_uc010zfh.1_Missense_Mutation_p.R7259C|TTN_uc010zfi.1_Missense_Mutation_p.R7192C|TTN_uc010zfj.1_Missense_Mutation_p.R7067C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14491							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179585746	179585746	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179585746G>A	uc010zfg.1	-	76	19492	c.19268C>T	c.(19267-19269)ACG>ATG	p.T6423M	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T3084M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7350							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
TTN	7273	broad.mit.edu	37	2	179647124	179647124	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179647124A>G	uc010zfg.1	-	20	3419	c.3195T>C	c.(3193-3195)ACT>ACC	p.T1065T	TTN_uc010zfh.1_Silent_p.T1019T|TTN_uc010zfi.1_Silent_p.T1019T|TTN_uc010zfj.1_Silent_p.T1019T|TTN_uc002unb.2_Silent_p.T1065T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1065							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)															---	---	---	---
CCDC141	285025	broad.mit.edu	37	2	179736188	179736188	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:179736188C>T	uc002unf.1	-	4	503	c.446G>A	c.(445-447)CGA>CAA	p.R149Q		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	149							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)															---	---	---	---
NCKAP1	10787	broad.mit.edu	37	2	183790471	183790471	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:183790471A>G	uc002upc.2	-	31	3748	c.3346T>C	c.(3346-3348)TAC>CAC	p.Y1116H	NCKAP1_uc002upb.2_Missense_Mutation_p.Y1122H	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	1116					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)															---	---	---	---
KCTD18	130535	broad.mit.edu	37	2	201363678	201363678	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:201363678C>T	uc002uvs.2	-	4	1019	c.502G>A	c.(502-504)GAT>AAT	p.D168N	KCTD18_uc002uvt.2_Missense_Mutation_p.D168N|KCTD18_uc002uvu.1_Missense_Mutation_p.D168N	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain	168						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1																		---	---	---	---
TRAK2	66008	broad.mit.edu	37	2	202254126	202254126	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:202254126G>A	uc002uyb.3	-	12	1740	c.1294C>T	c.(1294-1296)CGT>TGT	p.R432C		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	432	Interaction with HGS (By similarity).			Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0																		---	---	---	---
MAP2	4133	broad.mit.edu	37	2	210559607	210559607	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:210559607C>T	uc002vde.1	+	7	2961	c.2713C>T	c.(2713-2715)CGA>TGA	p.R905*	MAP2_uc002vdc.1_Nonsense_Mutation_p.R905*|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Nonsense_Mutation_p.R901*	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	905					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)													---	---	---	---
ATIC	471	broad.mit.edu	37	2	216214278	216214278	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:216214278C>T	uc002vex.3	+	16	1853	c.1679C>T	c.(1678-1680)GCG>GTG	p.A560V	ATIC_uc010zjo.1_Missense_Mutation_p.A501V|ATIC_uc002vey.3_Missense_Mutation_p.A559V	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	560					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)			T	ALK	ALCL								---	---	---	---
CXCR1	3577	broad.mit.edu	37	2	219028909	219028909	+	Silent	SNP	C	T	T	rs144791200	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219028909C>T	uc002vhc.2	-	2	1145	c.1026G>A	c.(1024-1026)TCG>TCA	p.S342S		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	342	Cytoplasmic (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2																		---	---	---	---
ZNF142	7701	broad.mit.edu	37	2	219508172	219508172	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:219508172G>A	uc002vin.2	-	8	3503	c.3067C>T	c.(3067-3069)CAG>TAG	p.Q1023*	ZNF142_uc002vil.2_Nonsense_Mutation_p.Q984*|ZNF142_uc010fvt.2_Nonsense_Mutation_p.Q860*|ZNF142_uc002vim.2_Nonsense_Mutation_p.Q860*	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1023					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)														---	---	---	---
SLC23A3	151295	broad.mit.edu	37	2	220027060	220027060	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220027060C>T	uc010zks.1	-	11	1609	c.1498G>A	c.(1498-1500)GCT>ACT	p.A500T	NHEJ1_uc002vjp.3_5'Flank|NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Missense_Mutation_p.A508T|SLC23A3_uc010fwb.2_Missense_Mutation_p.A383T	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	500	Helical; (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
GMPPA	29926	broad.mit.edu	37	2	220367131	220367131	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220367131G>A	uc002vlr.2	+	6	525	c.457G>A	c.(457-459)GGC>AGC	p.G153S	GMPPA_uc002vls.2_Missense_Mutation_p.G153S|GMPPA_uc002vlt.2_Missense_Mutation_p.G153S|GMPPA_uc002vlu.2_Missense_Mutation_p.G153S|GMPPA_uc002vlv.2_Missense_Mutation_p.G153S|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.G153S	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	153					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)														---	---	---	---
SLC4A3	6508	broad.mit.edu	37	2	220502391	220502391	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:220502391G>A	uc002vmp.3	+	17	2893	c.2624G>A	c.(2623-2625)AGT>AAT	p.S875N	SLC4A3_uc002vmo.3_Missense_Mutation_p.S902N|SLC4A3_uc010fwm.2_Missense_Mutation_p.S425N|SLC4A3_uc010fwn.1_Missense_Mutation_p.S384N	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	875	Membrane (anion exchange).			S -> C (in Ref. 2; AAB05850).	bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)														---	---	---	---
WDR69	164781	broad.mit.edu	37	2	228754563	228754563	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:228754563G>A	uc002vpn.1	+						WDR69_uc010zlw.1_Intron|WDR69_uc002vpo.1_Intron	NM_178821	NP_849143			WD repeat domain 69											breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)														---	---	---	---
GPR55	9290	broad.mit.edu	37	2	231775182	231775182	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:231775182A>G	uc002vrg.2	-	2	689	c.496T>C	c.(496-498)TAC>CAC	p.Y166H	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.Y166H	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	166	Extracellular (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)														---	---	---	---
CHRND	1144	broad.mit.edu	37	2	233393372	233393372	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233393372C>T	uc002vsw.2	+						CHRND_uc010zmg.1_Intron|CHRND_uc010fyc.2_Intron|CHRND_uc010zmh.1_Intron	NM_000751	NP_000742			nicotinic acetylcholine receptor delta						muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)														---	---	---	---
NEU2	4759	broad.mit.edu	37	2	233898912	233898912	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:233898912G>T	uc010zmn.1	+	2	288	c.288G>T	c.(286-288)GGG>GGT	p.G96G		NM_005383	NP_005374	Q9Y3R4	NEUR2_HUMAN	neuraminidase 2	96							exo-alpha-sialidase activity				0		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)														---	---	---	---
PER2	8864	broad.mit.edu	37	2	239169465	239169465	+	Intron	SNP	G	A	A	rs7603349		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:239169465G>A	uc002vyc.2	-						PER2_uc010znv.1_Intron	NM_022817	NP_073728			period 2						circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)														---	---	---	---
ANKMY1	51281	broad.mit.edu	37	2	241492466	241492466	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr2:241492466A>G	uc002vyz.1	-	3	307	c.78T>C	c.(76-78)CAT>CAC	p.H26H	ANKMY1_uc002vza.1_Silent_p.H115H|ANKMY1_uc010fzd.1_Silent_p.H115H|ANKMY1_uc002vzb.1_Silent_p.H115H|ANKMY1_uc002vzc.1_Silent_p.H115H|ANKMY1_uc002vzd.1_Silent_p.H115H|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Silent_p.H17H|ANKMY1_uc002vzf.2_Silent_p.H17H	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	26	MORN 2.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)														---	---	---	---
ITPR1	3708	broad.mit.edu	37	3	4829715	4829715	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:4829715C>T	uc003bqa.2	+	49	6904	c.6556C>T	c.(6556-6558)CGA>TGA	p.R2186*	ITPR1_uc010hca.1_Nonsense_Mutation_p.R2171*|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Nonsense_Mutation_p.R1156*	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2234	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)														---	---	---	---
SRGAP3	9901	broad.mit.edu	37	3	9027584	9027584	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9027584G>A	uc003brf.1	-	22	3595	c.2919C>T	c.(2917-2919)CAC>CAT	p.H973H	SRGAP3_uc003brg.1_Silent_p.H949H	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	973	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)				T	RAF1	pilocytic astrocytoma								---	---	---	---
SRGAP3	9901	broad.mit.edu	37	3	9094775	9094775	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9094775A>G	uc003brf.1	-	9	1935	c.1259T>C	c.(1258-1260)ATG>ACG	p.M420T	SRGAP3_uc003brg.1_Missense_Mutation_p.M420T|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brj.1_Missense_Mutation_p.M280T	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	420					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)				T	RAF1	pilocytic astrocytoma								---	---	---	---
IL17RC	84818	broad.mit.edu	37	3	9972608	9972608	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:9972608G>T	uc003bua.2	+	16	1817	c.1581G>T	c.(1579-1581)TGG>TGT	p.W527C	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_Missense_Mutation_p.W456C|IL17RC_uc011atp.1_Missense_Mutation_p.W295C|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Missense_Mutation_p.W441C|IL17RC_uc010hct.2_Missense_Mutation_p.W456C|IL17RC_uc010hcu.2_Missense_Mutation_p.W439C|IL17RC_uc010hcv.2_Missense_Mutation_p.W424C|IL17RC_uc011atq.1_Missense_Mutation_p.W441C|IL17RC_uc003buc.2_5'UTR|IL17RC_uc003bue.2_Missense_Mutation_p.W92C|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	527	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
SEC13	6396	broad.mit.edu	37	3	10357042	10357042	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:10357042G>A	uc003bvn.2	-	3	246	c.127C>T	c.(127-129)CGC>TGC	p.R43C	SEC13_uc003bvl.2_5'Flank|SEC13_uc003bvm.2_Missense_Mutation_p.R29C|SEC13_uc003bvp.2_Missense_Mutation_p.R46C|SEC13_uc003bvo.2_Missense_Mutation_p.R89C|SEC13_uc003bvq.1_Missense_Mutation_p.R29C|SEC13_uc003bvr.1_Missense_Mutation_p.R29C|SEC13_uc011aul.1_Missense_Mutation_p.R43C	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	43	WD 1.				COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding	p.R43H(1)		ovary(1)	1																		---	---	---	---
IQSEC1	9922	broad.mit.edu	37	3	12949857	12949857	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:12949857G>A	uc003bxt.2	-	12	2798	c.2789C>T	c.(2788-2790)TCG>TTG	p.S930L	IQSEC1_uc003bxu.3_Missense_Mutation_p.S808L|IQSEC1_uc011auw.1_Missense_Mutation_p.S916L	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	930					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1																		---	---	---	---
FBLN2	2199	broad.mit.edu	37	3	13672308	13672308	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:13672308C>A	uc011avb.1	+	14	3062	c.2937C>A	c.(2935-2937)ACC>ACA	p.T979T	FBLN2_uc011auz.1_Silent_p.T1005T|FBLN2_uc011ava.1_Silent_p.T1026T|FBLN2_uc011avc.1_Silent_p.T1026T	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	979	EGF-like 8; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)															---	---	---	---
FGD5	152273	broad.mit.edu	37	3	14861889	14861889	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14861889C>T	uc003bzc.2	+	1	1421	c.1311C>T	c.(1309-1311)CCC>CCT	p.P437P	FGD5_uc011avk.1_Silent_p.P437P	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	437					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5																		---	---	---	---
FGD5	152273	broad.mit.edu	37	3	14905734	14905734	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:14905734C>T	uc003bzc.2	+	2	2735	c.2625C>T	c.(2623-2625)GAC>GAT	p.D875D	FGD5_uc011avk.1_Silent_p.D875D	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	875					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5																		---	---	---	---
STT3B	201595	broad.mit.edu	37	3	31674521	31674521	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:31674521C>T	uc011axe.1	+	15	2282	c.2282C>T	c.(2281-2283)ACA>ATA	p.T761I		NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	761					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0																		---	---	---	---
TRIM71	131405	broad.mit.edu	37	3	32932608	32932608	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:32932608G>A	uc003cff.2	+	4	1975	c.1912G>A	c.(1912-1914)GCC>ACC	p.A638T		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	638					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3																		---	---	---	---
SCN5A	6331	broad.mit.edu	37	3	38595794	38595794	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:38595794C>T	uc003cio.2	-	27	4983	c.4789G>A	c.(4789-4791)GTG>ATG	p.V1597M	SCN5A_uc003cin.2_Missense_Mutation_p.V1596M|SCN5A_uc003cil.3_Missense_Mutation_p.V1597M|SCN5A_uc010hhi.2_Missense_Mutation_p.V1579M|SCN5A_uc010hhk.2_Intron|SCN5A_uc011ayr.1_Missense_Mutation_p.V1543M	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1597	Helical; Name=S3 of repeat IV; (Potential).				blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)													---	---	---	---
RPSA	3921	broad.mit.edu	37	3	39453212	39453212	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:39453212C>T	uc003cjp.2	+	5	656	c.571C>T	c.(571-573)CGT>TGT	p.R191C	RPSA_uc003cjq.2_Missense_Mutation_p.R196C|RPSA_uc003cjr.2_Missense_Mutation_p.R191C|RPSA_uc003cjt.2_RNA	NM_002295	NP_002286	P08865	RSSA_HUMAN	ribosomal protein SA	191					cell adhesion|endocrine pancreas development|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly|rRNA export from nucleus|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleus|plasma membrane	protein binding|receptor activity|ribosome binding|structural constituent of ribosome			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0509)|Kidney(284;0.064)														---	---	---	---
MYRIP	25924	broad.mit.edu	37	3	40251426	40251426	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:40251426C>T	uc003cka.2	+	11	1882	c.1747C>T	c.(1747-1749)CGG>TGG	p.R583W	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.R583W|MYRIP_uc010hhw.2_Missense_Mutation_p.R494W|MYRIP_uc011ayz.1_Missense_Mutation_p.R396W|uc003ckb.2_Intron	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	583	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)														---	---	---	---
C3orf39	84892	broad.mit.edu	37	3	43121172	43121172	+	3'UTR	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:43121172G>T	uc003cmq.1	-	2					C3orf39_uc003cmr.1_3'UTR	NM_032806	NP_116195			glycosyltransferase precursor							extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)														---	---	---	---
CDCP1	64866	broad.mit.edu	37	3	45132849	45132849	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:45132849G>A	uc003com.2	-	7	1944	c.1809C>T	c.(1807-1809)CGC>CGT	p.R603R		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	603	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)														---	---	---	---
XCR1	2829	broad.mit.edu	37	3	46063062	46063062	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46063062G>A	uc003cpe.2	-	3	602	c.378C>T	c.(376-378)CAC>CAT	p.H126H	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Silent_p.H126H	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	126	Cytoplasmic (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)														---	---	---	---
PRSS45	377047	broad.mit.edu	37	3	46786212	46786212	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:46786212G>A	uc010hjl.2	-	1	34	c.34C>T	c.(34-36)CGG>TGG	p.R12W	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	12	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0																		---	---	---	---
SMARCC1	6599	broad.mit.edu	37	3	47779562	47779562	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:47779562C>T	uc003crq.2	-	4	558	c.440G>A	c.(439-441)CGT>CAT	p.R147H	SMARCC1_uc011bbd.1_Missense_Mutation_p.R38H	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	147					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)														---	---	---	---
PLXNB1	5364	broad.mit.edu	37	3	48459679	48459679	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48459679C>T	uc003csw.2	-	15	3413	c.3143G>A	c.(3142-3144)CGT>CAT	p.R1048H	PLXNB1_uc003csu.2_Missense_Mutation_p.R865H|PLXNB1_uc003csx.2_Missense_Mutation_p.R1048H|PLXNB1_uc010hjx.1_RNA|PLXNB1_uc003csy.1_5'Flank	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1048	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48686617	48686617	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48686617C>A	uc003cul.2	-	17	6785	c.6504G>T	c.(6502-6504)CAG>CAT	p.Q2168H	CELSR3_uc003cuf.1_Missense_Mutation_p.Q2238H|CELSR3_uc010hkg.2_Missense_Mutation_p.Q151H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2168	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
CELSR3	1951	broad.mit.edu	37	3	48699637	48699637	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48699637C>T	uc003cul.2	-	1	712	c.431G>A	c.(430-432)CGG>CAG	p.R144Q	CELSR3_uc003cuf.1_Missense_Mutation_p.R214Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	144	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)														---	---	---	---
SLC25A20	788	broad.mit.edu	37	3	48897000	48897000	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:48897000G>A	uc003cva.3	-	6	771	c.596C>T	c.(595-597)CCG>CTG	p.P199L	SLC25A20_uc011bbw.1_Missense_Mutation_p.P149L|SLC25A20_uc010hkj.2_Missense_Mutation_p.P126L	NM_000387	NP_000378	O43772	MCAT_HUMAN	carnitine/acylcarnitine translocase	199	Cytoplasmic (Potential).				carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity				0				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)													---	---	---	---
BSN	8927	broad.mit.edu	37	3	49698234	49698234	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49698234C>T	uc003cxe.3	+	6	9070	c.8956C>T	c.(8956-8958)CGC>TGC	p.R2986C		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	2986					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)														---	---	---	---
IP6K1	9807	broad.mit.edu	37	3	49785304	49785304	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:49785304C>T	uc003cxm.1	-	2	485	c.170G>A	c.(169-171)CGC>CAC	p.R57H	IP6K1_uc003cxn.1_Intron|IP6K1_uc011bcv.1_Intron|IP6K1_uc003cxo.2_Missense_Mutation_p.R57H	NM_153273	NP_695005	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1 isoform 1	57					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0																		---	---	---	---
DOCK3	1795	broad.mit.edu	37	3	51308421	51308421	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51308421G>A	uc011bds.1	+	24	2554	c.2531G>A	c.(2530-2532)CGC>CAC	p.R844H		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	844						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)														---	---	---	---
IQCF1	132141	broad.mit.edu	37	3	51929286	51929286	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:51929286G>A	uc003dbv.2	-	4	336	c.238C>T	c.(238-240)CGG>TGG	p.R80W	IQCF1_uc003dbq.3_Intron	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	80	IQ 1.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)														---	---	---	---
ALAS1	211	broad.mit.edu	37	3	52233439	52233439	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:52233439C>A	uc003dcy.1	+	3	519	c.182C>A	c.(181-183)ACC>AAC	p.T61N	ALAS1_uc003dcx.1_Missense_Mutation_p.T61N|ALAS1_uc003dcz.1_Missense_Mutation_p.T61N|ALAS1_uc011bec.1_Missense_Mutation_p.T78N	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	61					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)													---	---	---	---
RFT1	91869	broad.mit.edu	37	3	53126488	53126488	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53126488C>T	uc003dgj.2	-	12	1409	c.1355G>A	c.(1354-1356)CGC>CAC	p.R452H	RFT1_uc003dgk.2_Missense_Mutation_p.R413H	NM_052859	NP_443091	Q96AA3	RFT1_HUMAN	RFT1 homolog	452					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)														---	---	---	---
CHDH	55349	broad.mit.edu	37	3	53856562	53856562	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:53856562G>A	uc003dgz.2	-	4	1251	c.811C>T	c.(811-813)CGT>TGT	p.R271C		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	271					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)													---	---	---	---
CACNA2D3	55799	broad.mit.edu	37	3	54914835	54914835	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:54914835G>A	uc003dhf.2	+	21	1905	c.1857G>A	c.(1855-1857)GCG>GCA	p.A619A	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Silent_p.A525A|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Silent_p.A353A|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	619	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)														---	---	---	---
ARHGEF3	50650	broad.mit.edu	37	3	56771219	56771219	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:56771219C>T	uc003dig.2	-	8	1204	c.1035G>A	c.(1033-1035)CGG>CGA	p.R345R	ARHGEF3_uc011bew.1_Silent_p.R345R|ARHGEF3_uc003dih.2_Silent_p.R377R|ARHGEF3_uc011bev.1_Silent_p.R316R|ARHGEF3_uc003dif.2_Silent_p.R351R|ARHGEF3_uc010hmy.1_Silent_p.R143R|ARHGEF3_uc003dii.2_Silent_p.R345R	NM_019555	NP_062455	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor 3 isoform	345	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)														---	---	---	---
ATXN7	6314	broad.mit.edu	37	3	63938114	63938114	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:63938114G>A	uc003dlw.3	+	5	1007	c.454G>A	c.(454-456)GAC>AAC	p.D152N	ATXN7_uc003dlv.2_Missense_Mutation_p.D152N|ATXN7_uc010hnv.2_Missense_Mutation_p.D152N	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	152					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)														---	---	---	---
ROBO2	6092	broad.mit.edu	37	3	77614178	77614178	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:77614178C>T	uc003dpy.3	+	12	2399	c.1756C>T	c.(1756-1758)CGG>TGG	p.R586W	ROBO2_uc003dpz.2_Missense_Mutation_p.R590W|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.R590W	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	586	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)														---	---	---	---
ROBO1	6091	broad.mit.edu	37	3	78717036	78717036	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:78717036G>A	uc003dqe.2	-	14	2171	c.1963C>T	c.(1963-1965)CAA>TAA	p.Q655*	ROBO1_uc003dqb.2_Nonsense_Mutation_p.Q616*|ROBO1_uc003dqc.2_Nonsense_Mutation_p.Q619*|ROBO1_uc003dqd.2_Nonsense_Mutation_p.Q619*|ROBO1_uc010hoh.2_5'UTR|ROBO1_uc011bgl.1_Nonsense_Mutation_p.Q227*|ROBO1_uc003dqf.1_Nonsense_Mutation_p.Q334*	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	655	Extracellular (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)														---	---	---	---
GABRR3	200959	broad.mit.edu	37	3	97731224	97731224	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:97731224C>T	uc011bgr.1	-	4	494	c.494G>A	c.(493-495)CGC>CAC	p.R165H		NM_001105580	NP_001099050	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 3	165	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0																		---	---	---	---
IMPG2	50939	broad.mit.edu	37	3	101023021	101023021	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:101023021T>C	uc003duq.1	-	3	673	c.470A>G	c.(469-471)GAA>GGA	p.E157G	IMPG2_uc011bhe.1_Missense_Mutation_p.E20G	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	157	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3																		---	---	---	---
CD200R1L	344807	broad.mit.edu	37	3	112546413	112546413	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:112546413G>A	uc003dzi.1	-	3	457	c.231C>T	c.(229-231)TGC>TGT	p.C77C	CD200R1L_uc011bhw.1_Silent_p.C56C|CD200R1L_uc010hqf.1_Silent_p.C56C	NM_001008784	NP_001008784	Q6Q8B3	MO2R2_HUMAN	CD200 cell surface glycoprotein receptor 2	77	Ig-like V-type.|Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)	1																		---	---	---	---
CCDC52	152185	broad.mit.edu	37	3	113184616	113184616	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113184616G>A	uc003eag.3	-	11	1462	c.1171C>T	c.(1171-1173)CGT>TGT	p.R391C	CCDC52_uc003eaf.3_RNA|CCDC52_uc003eah.1_Missense_Mutation_p.R287C	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	391	Potential.				cell division|mitosis	centriole|spindle	protein binding				0																		---	---	---	---
KIAA2018	205717	broad.mit.edu	37	3	113374252	113374252	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:113374252T>C	uc003eam.2	-	7	6688	c.6277A>G	c.(6277-6279)ACT>GCT	p.T2093A	KIAA2018_uc003eal.2_Missense_Mutation_p.T2037A	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	2093					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3																		---	---	---	---
ZBTB20	26137	broad.mit.edu	37	3	114069778	114069778	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:114069778T>C	uc003ebi.2	-	4	1327	c.1147A>G	c.(1147-1149)ATA>GTA	p.I383V	ZBTB20_uc003ebj.2_Missense_Mutation_p.I310V|ZBTB20_uc010hqp.2_Missense_Mutation_p.I310V|ZBTB20_uc003ebk.2_Missense_Mutation_p.I310V|ZBTB20_uc003ebl.2_Missense_Mutation_p.I310V|ZBTB20_uc003ebm.2_Missense_Mutation_p.I310V|ZBTB20_uc003ebn.2_Missense_Mutation_p.I310V|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	383					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)														---	---	---	---
C3orf30	152405	broad.mit.edu	37	3	118866168	118866168	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:118866168G>T	uc003ecb.1	+	1	1172	c.1132G>T	c.(1132-1134)GGC>TGC	p.G378C	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.G378C	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	378										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)														---	---	---	---
ARHGAP31	57514	broad.mit.edu	37	3	119120866	119120866	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119120866G>A	uc003ecj.3	+	10	1799	c.1267G>A	c.(1267-1269)GCT>ACT	p.A423T		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	423					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2																		---	---	---	---
C3orf15	89876	broad.mit.edu	37	3	119434407	119434407	+	Splice_Site	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:119434407A>G	uc003ede.3	+	6	578	c.501_splice	c.e6-2	p.K167_splice	C3orf15_uc003edc.2_Splice_Site_p.K167_splice|C3orf15_uc010hqy.1_Splice_Site_p.K167_splice|C3orf15_uc010hqz.2_Splice_Site_p.K105_splice|C3orf15_uc011bjd.1_Splice_Site_p.K41_splice|C3orf15_uc011bje.1_Splice_Site_p.K147_splice|C3orf15_uc010hra.1_Splice_Site	NM_033364	NP_203528			AAT1-alpha							mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)														---	---	---	---
UROC1	131669	broad.mit.edu	37	3	126236457	126236457	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126236457G>T	uc003eiz.1	-	1	138	c.106C>A	c.(106-108)CTC>ATC	p.L36I	UROC1_uc010hsi.1_Missense_Mutation_p.L36I	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	36					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126733584	126733584	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126733584C>A	uc003ejg.2	+	13	2722	c.2718C>A	c.(2716-2718)TCC>TCA	p.S906S		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	929	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
PLXNA1	5361	broad.mit.edu	37	3	126749082	126749082	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:126749082G>A	uc003ejg.2	+						PLXNA1_uc003ejh.2_Intron	NM_032242	NP_115618			plexin A1						axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)														---	---	---	---
EEFSEC	60678	broad.mit.edu	37	3	128060188	128060188	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128060188G>A	uc003eki.2	+	5	937	c.899G>A	c.(898-900)CGC>CAC	p.R300H	EEFSEC_uc003ekj.2_Missense_Mutation_p.R245H	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	300						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1																		---	---	---	---
RAB7A	7879	broad.mit.edu	37	3	128526462	128526462	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:128526462C>T	uc003eks.1	+	5	708	c.476C>T	c.(475-477)GCC>GTC	p.A159V	RAB7A_uc010hsv.1_Missense_Mutation_p.A112V|RAB7A_uc003ekt.2_Intron	NM_004637	NP_004628	P51149	RAB7A_HUMAN	RAB7, member RAS oncogene family	159					endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding				0				GBM - Glioblastoma multiforme(114;0.231)														---	---	---	---
ASTE1	28990	broad.mit.edu	37	3	130743433	130743433	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:130743433G>A	uc003env.1	-	3	1160	c.718C>T	c.(718-720)CGT>TGT	p.R240C	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Missense_Mutation_p.R240C|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	240					DNA repair		nuclease activity				0																		---	---	---	---
NCK1	4690	broad.mit.edu	37	3	136664467	136664467	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:136664467C>T	uc003erh.2	+	3	376	c.269C>T	c.(268-270)GCA>GTA	p.A90V	NCK1_uc011bme.1_Missense_Mutation_p.A26V	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	90					axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1																		---	---	---	---
SPSB4	92369	broad.mit.edu	37	3	140785469	140785469	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:140785469G>A	uc003ett.2	+	2	777	c.523G>A	c.(523-525)GAC>AAC	p.D175N	SPSB4_uc010hum.2_Missense_Mutation_p.D175N	NM_080862	NP_543138	Q96A44	SPSB4_HUMAN	splA/ryanodine receptor domain and SOCS box	175	B30.2/SPRY.				intracellular signal transduction	cytoplasm	protein binding				0																		---	---	---	---
XRN1	54464	broad.mit.edu	37	3	142151518	142151518	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:142151518C>T	uc003eus.2	-	2	360	c.293G>A	c.(292-294)CGT>CAT	p.R98H	XRN1_uc003eut.2_Missense_Mutation_p.R98H|XRN1_uc003euu.2_Missense_Mutation_p.R98H|XRN1_uc003euw.2_Missense_Mutation_p.R98H|XRN1_uc011bnh.1_Translation_Start_Site	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	98					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3																		---	---	---	---
PLSCR1	5359	broad.mit.edu	37	3	146233845	146233845	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:146233845G>A	uc003evx.3	-	9	1332	c.944C>T	c.(943-945)TCA>TTA	p.S315L	PLSCR1_uc003evy.3_Missense_Mutation_p.S308L|PLSCR1_uc011bnn.1_Missense_Mutation_p.S234L|PLSCR1_uc003evz.3_RNA	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	315	Extracellular.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2																		---	---	---	---
ZIC1	7545	broad.mit.edu	37	3	147128311	147128311	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:147128311G>A	uc003ewe.2	+	1	1131	c.412G>A	c.(412-414)GCG>ACG	p.A138T		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	138					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
HPS3	84343	broad.mit.edu	37	3	148858981	148858981	+	Intron	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:148858981A>G	uc003ewu.1	+						HPS3_uc003ewt.1_Intron|HPS3_uc011bnq.1_Intron	NM_032383	NP_115759			Hermansky-Pudlak syndrome 3 protein							cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)											Hermansky-Pudlak_syndrome				---	---	---	---
MED12L	116931	broad.mit.edu	37	3	150873939	150873939	+	Intron	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:150873939A>T	uc003eyp.2	+						MED12L_uc011bnz.1_Intron|MED12L_uc003eym.1_Intron|MED12L_uc003eyn.2_Intron|MED12L_uc003eyo.2_Intron	NM_053002	NP_443728			mediator of RNA polymerase II transcription,						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)															---	---	---	---
AADAC	13	broad.mit.edu	37	3	151545391	151545391	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:151545391A>G	uc003eze.2	+	5	721	c.631A>G	c.(631-633)AAA>GAA	p.K211E		NM_001086	NP_001077	P22760	AAAD_HUMAN	arylacetamide deacetylase	211	Lumenal (Potential).				positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			skin(2)	2		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)															---	---	---	---
MFSD1	64747	broad.mit.edu	37	3	158541915	158541915	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:158541915T>C	uc003fcl.1	+	13	1208	c.1178T>C	c.(1177-1179)ATG>ACG	p.M393T	MFSD1_uc003fcm.1_RNA|MFSD1_uc003fcn.1_Missense_Mutation_p.M296T|MFSD1_uc011bow.1_Missense_Mutation_p.M354T|MFSD1_uc011box.1_Missense_Mutation_p.M320T	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing	393	Helical; (Potential).				transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)															---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167248986	167248986	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167248986C>T	uc003fev.1	-	9	1385	c.1079G>A	c.(1078-1080)CGC>CAC	p.R360H	WDR49_uc003feu.1_Missense_Mutation_p.R185H|WDR49_uc011bpd.1_Missense_Mutation_p.R424H|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	360										large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
WDR49	151790	broad.mit.edu	37	3	167277927	167277927	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:167277927G>A	uc003fev.1	-	5	882	c.576C>T	c.(574-576)AAC>AAT	p.N192N	WDR49_uc003feu.1_Silent_p.N17N|WDR49_uc011bpd.1_Silent_p.N245N|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	192	WD 4.									large_intestine(1)|ovary(1)|skin(1)	3																		---	---	---	---
TNIK	23043	broad.mit.edu	37	3	170819285	170819285	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:170819285G>A	uc003fhh.2	-	22	2889	c.2544C>T	c.(2542-2544)AGC>AGT	p.S848S	TNIK_uc003fhi.2_Silent_p.S793S|TNIK_uc003fhj.2_Silent_p.S819S|TNIK_uc003fhk.2_Silent_p.S840S|TNIK_uc003fhl.2_Silent_p.S764S|TNIK_uc003fhm.2_Silent_p.S785S|TNIK_uc003fhn.2_Silent_p.S811S|TNIK_uc003fho.2_Silent_p.S756S|TNIK_uc003fhg.2_Silent_p.S26S	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	848	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)															---	---	---	---
PLD1	5337	broad.mit.edu	37	3	171427481	171427481	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:171427481G>A	uc003fhs.2	-	10	1046	c.930C>T	c.(928-930)TGC>TGT	p.C310C	PLD1_uc003fht.2_Silent_p.C310C	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	310	PH.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)													---	---	---	---
SPATA16	83893	broad.mit.edu	37	3	172835263	172835263	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:172835263C>T	uc003fin.3	-	2	417	c.259G>A	c.(259-261)GAA>AAA	p.E87K		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	87					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)															---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178916891	178916891	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178916891G>A	uc003fjk.2	+	2	435	c.278G>A	c.(277-279)CGG>CAG	p.R93Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	93	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R93W(5)|p.R93Q(3)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PIK3CA	5290	broad.mit.edu	37	3	178936096	178936096	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:178936096G>T	uc003fjk.2	+	10	1795	c.1638G>T	c.(1636-1638)CAG>CAT	p.Q546H		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	546	PI3K helical.		Q -> K (in cancer).|Q -> P (in cancer).|Q -> E (in cancer).|Q -> R (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.Q546K(54)|p.Q546R(17)|p.Q546P(10)|p.Q546E(9)|p.Q546L(6)|p.Q546H(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)				57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			---	---	---	---
PSMD2	5708	broad.mit.edu	37	3	184020259	184020259	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184020259C>T	uc003fnn.1	+	6	839	c.806C>T	c.(805-807)GCA>GTA	p.A269V	PSMD2_uc011brj.1_Missense_Mutation_p.A110V|PSMD2_uc011brk.1_Missense_Mutation_p.A139V	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	269					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)													---	---	---	---
EPHB3	2049	broad.mit.edu	37	3	184298851	184298851	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:184298851G>A	uc003foz.2	+	14	3067	c.2630G>A	c.(2629-2631)CGG>CAG	p.R877Q		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	877	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)															---	---	---	---
DNAJB11	51726	broad.mit.edu	37	3	186302256	186302256	+	Missense_Mutation	SNP	C	T	T	rs139219315		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:186302256C>T	uc003fqi.2	+	9	1110	c.890C>T	c.(889-891)GCG>GTG	p.A297V		NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	297					protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)														---	---	---	---
PAK2	5062	broad.mit.edu	37	3	196554152	196554152	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196554152G>A	uc003fwy.3	+	14	1758	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	479	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)														---	---	---	---
DLG1	1739	broad.mit.edu	37	3	196846372	196846372	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:196846372T>C	uc003fxo.3	-	13	1484	c.1294A>G	c.(1294-1296)AGC>GGC	p.S432G	DLG1_uc011bub.1_Missense_Mutation_p.S316G|DLG1_uc011buc.1_Missense_Mutation_p.S316G|DLG1_uc011bud.1_Missense_Mutation_p.S115G|DLG1_uc003fxn.3_Missense_Mutation_p.S432G|DLG1_uc011bue.1_Missense_Mutation_p.S399G|DLG1_uc010ial.2_Missense_Mutation_p.S432G|DLG1_uc011buf.1_Intron|DLG1_uc003fxp.2_RNA|DLG1_uc010iam.1_Missense_Mutation_p.S399G|DLG1_uc010ian.2_Missense_Mutation_p.S299G	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	432					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)														---	---	---	---
IQCG	84223	broad.mit.edu	37	3	197670853	197670853	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr3:197670853G>A	uc003fyo.2	-	3	224	c.78C>T	c.(76-78)GGC>GGT	p.G26G	IQCG_uc003fyp.2_Silent_p.G26G|IQCG_uc003fyq.3_Silent_p.G26G	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	26											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)														---	---	---	---
PDE6B	5158	broad.mit.edu	37	4	660390	660390	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:660390C>T	uc003gap.2	+	20	2392	c.2339C>T	c.(2338-2340)ACA>ATA	p.T780I	PDE6B_uc003gao.3_Missense_Mutation_p.T780I|PDE6B_uc011buy.1_Missense_Mutation_p.T501I|PDE6B_uc011buz.1_Missense_Mutation_p.T212I	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	780					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0																		---	---	---	---
MFSD7	84179	broad.mit.edu	37	4	679630	679630	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:679630C>T	uc003gay.2	-	4	636	c.579G>A	c.(577-579)CCG>CCA	p.P193P	MFSD7_uc003gaw.2_5'Flank|MFSD7_uc003gax.2_Silent_p.P193P|MFSD7_uc003gaz.2_Intron|MFSD7_uc003gba.2_Intron|MFSD7_uc003gbb.1_Silent_p.P129P	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	193	Helical; (Potential).				transmembrane transport	integral to membrane					0																		---	---	---	---
TMEM175	84286	broad.mit.edu	37	4	951745	951745	+	Missense_Mutation	SNP	G	A	A	rs143946130		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:951745G>A	uc003gbq.2	+	11	1074	c.976G>A	c.(976-978)GCC>ACC	p.A326T	TMEM175_uc003gbr.2_Missense_Mutation_p.A244T|TMEM175_uc003gbu.2_Missense_Mutation_p.A244T|TMEM175_uc003gbs.2_Missense_Mutation_p.A209T|TMEM175_uc003gbt.2_Missense_Mutation_p.A209T|TMEM175_uc003gbv.2_Missense_Mutation_p.A209T|TMEM175_uc010ibm.2_Missense_Mutation_p.A142T	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	326	Helical; (Potential).					integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)															---	---	---	---
CTBP1	1487	broad.mit.edu	37	4	1209851	1209851	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1209851G>A	uc003gcv.1	-	5	855	c.690C>T	c.(688-690)AGC>AGT	p.S230S	uc003gcs.1_RNA|CTBP1_uc003gct.1_Silent_p.S211S|CTBP1_uc003gcu.1_Silent_p.S219S|CTBP1_uc003gcw.2_5'Flank	NM_001328	NP_001319	Q13363	CTBP1_HUMAN	C-terminal binding protein 1 isoform 1	230					interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)														---	---	---	---
MAEA	10296	broad.mit.edu	37	4	1326665	1326665	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:1326665G>A	uc003gda.2	+						MAEA_uc003gdb.2_Intron|MAEA_uc011bvb.1_Intron|MAEA_uc003gdc.2_Intron|MAEA_uc003gdd.2_Intron|MAEA_uc011bvc.1_Intron|MAEA_uc011bvd.1_Intron|MAEA_uc010ibt.2_Intron|MAEA_uc010ibu.2_Intron	NM_001017405	NP_001017405			macrophage erythroblast attacher isoform 1						cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0201)															---	---	---	---
POLN	353497	broad.mit.edu	37	4	2077179	2077179	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2077179C>A	uc003ger.2	-	22	2455	c.2455G>T	c.(2455-2457)GCT>TCT	p.A819S	POLN_uc010icg.1_Missense_Mutation_p.A267S	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	819					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)										DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
RNF4	6047	broad.mit.edu	37	4	2515435	2515435	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2515435C>T	uc003gfb.2	+	8	798	c.462C>T	c.(460-462)TGC>TGT	p.C154C	RNF4_uc010icj.2_Missense_Mutation_p.A101V|RNF4_uc003gfc.2_Silent_p.C154C	NM_002938	NP_002929	P78317	RNF4_HUMAN	ring finger protein 4	154	RING-type.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination|regulation of kinetochore assembly|regulation of spindle assembly|response to arsenic-containing substance	cytoplasm|PML body	androgen receptor binding|DNA binding|nucleosome binding|sequence-specific DNA binding transcription factor activity|SUMO polymer binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(65;0.241)																---	---	---	---
FAM193A	8603	broad.mit.edu	37	4	2661728	2661728	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:2661728A>G	uc010icl.2	+	8	1170	c.819A>G	c.(817-819)ACA>ACG	p.T273T	FAM193A_uc010ick.2_Silent_p.T473T|FAM193A_uc003gfd.2_Silent_p.T273T|FAM193A_uc011bvm.1_Silent_p.T297T|FAM193A_uc011bvn.1_Silent_p.T273T|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Silent_p.T127T	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	273										ovary(3)	3																		---	---	---	---
EVC	2121	broad.mit.edu	37	4	5800369	5800369	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:5800369G>T	uc003gil.1	+	15	2338	c.2154G>T	c.(2152-2154)CGG>CGT	p.R718R	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	718					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)																---	---	---	---
TBC1D14	57533	broad.mit.edu	37	4	6925428	6925428	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:6925428C>A	uc011bwg.1	+	2	391	c.312C>A	c.(310-312)GCC>GCA	p.A104A	TBC1D14_uc003gjs.3_Silent_p.A104A	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a	104						intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TADA2B	93624	broad.mit.edu	37	4	7056590	7056590	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7056590C>A	uc003gjw.3	+	2	1223	c.1072C>A	c.(1072-1074)CTC>ATC	p.L358I	TADA2B_uc010idi.2_Missense_Mutation_p.L283I	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0																		---	---	---	---
AFAP1	60312	broad.mit.edu	37	4	7802200	7802200	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:7802200A>G	uc003gkg.1	-	10	1508	c.1235T>C	c.(1234-1236)CTG>CCG	p.L412P	AFAP1_uc011bwk.1_Missense_Mutation_p.L412P	NM_198595	NP_940997	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	412	PH 2.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding				0																		---	---	---	---
FBXL5	26234	broad.mit.edu	37	4	15607351	15607351	+	Missense_Mutation	SNP	C	T	T	rs143196332		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:15607351C>T	uc003goc.1	-	11	2174	c.2071G>A	c.(2071-2073)GAA>AAA	p.E691K	FBXL5_uc010idw.1_Missense_Mutation_p.E604K|FBXL5_uc003gob.1_Missense_Mutation_p.E565K|FBXL5_uc010idx.1_Missense_Mutation_p.E690K|FBXL5_uc003god.1_Missense_Mutation_p.E674K	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	691					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0																		---	---	---	---
RBPJ	3516	broad.mit.edu	37	4	26364239	26364239	+	Intron	SNP	G	A	A	rs144563091		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:26364239G>A	uc003grx.1	+						RBPJ_uc003gry.1_Intron|RBPJ_uc003grz.1_Intron|RBPJ_uc011bxt.1_Intron|RBPJ_uc003gsa.1_Silent_p.A2A|RBPJ_uc003gsb.1_Intron|RBPJ_uc003gsc.1_Silent_p.A2A	NM_005349	NP_005340			recombining binding protein suppressor of						DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)																---	---	---	---
ARAP2	116984	broad.mit.edu	37	4	36109211	36109211	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:36109211C>T	uc003gsq.1	-	27	4599	c.4261G>A	c.(4261-4263)GCT>ACT	p.A1421T		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1421					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3																		---	---	---	---
WDR19	57728	broad.mit.edu	37	4	39274601	39274601	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:39274601T>A	uc003gtv.2	+	32	3639	c.3485T>A	c.(3484-3486)ATT>AAT	p.I1162N	WDR19_uc011byi.1_Missense_Mutation_p.I1002N|WDR19_uc003gtw.1_Missense_Mutation_p.I759N	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1162					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1																		---	---	---	---
PHOX2B	8929	broad.mit.edu	37	4	41748145	41748145	+	Nonsense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41748145G>T	uc003gwf.3	-	3	984	c.624C>A	c.(622-624)TGC>TGA	p.C208*		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	208					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12								Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				---	---	---	---
TMEM33	55161	broad.mit.edu	37	4	41956148	41956148	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:41956148C>T	uc003gwi.2	+	7	1041	c.676C>T	c.(676-678)CTG>TTG	p.L226L	TMEM33_uc010ifw.2_RNA	NM_018126	NP_060596	P57088	TMM33_HUMAN	transmembrane protein 33	226						integral to membrane|melanosome	protein binding			ovary(1)	1																		---	---	---	---
CORIN	10699	broad.mit.edu	37	4	47605501	47605501	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:47605501G>A	uc003gxm.2	-	20	2818	c.2725C>T	c.(2725-2727)CGG>TGG	p.R909W	CORIN_uc011bzf.1_Missense_Mutation_p.R770W|CORIN_uc011bzg.1_Missense_Mutation_p.R842W	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	909	Extracellular (Potential).|Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
OCIAD1	54940	broad.mit.edu	37	4	48862748	48862748	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48862748T>C	uc003gyo.2	+	9	964	c.707T>C	c.(706-708)GTA>GCA	p.V236A	OCIAD1_uc003gyr.2_Missense_Mutation_p.V236A|OCIAD1_uc003gyp.2_3'UTR|OCIAD1_uc003gys.2_3'UTR|OCIAD1_uc003gyq.2_Missense_Mutation_p.V185A|OCIAD1_uc010igk.2_Missense_Mutation_p.V241A	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	236						endosome	protein binding				0																		---	---	---	---
OCIAD2	132299	broad.mit.edu	37	4	48894819	48894819	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:48894819C>T	uc003gyt.2	-	6	556	c.353G>A	c.(352-354)CGT>CAT	p.R118H	OCIAD2_uc003gyu.2_Intron	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1	118	OCIA.					endosome					0																		---	---	---	---
LRRC66	339977	broad.mit.edu	37	4	52861027	52861027	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52861027C>T	uc003gzi.2	-	4	2174	c.2161G>A	c.(2161-2163)GCA>ACA	p.A721T		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	721						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
LRRC66	339977	broad.mit.edu	37	4	52862277	52862277	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:52862277C>T	uc003gzi.2	-	4	924	c.911G>A	c.(910-912)CGC>CAC	p.R304H		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	304						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
FIP1L1	81608	broad.mit.edu	37	4	54319243	54319243	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:54319243G>A	uc003gzy.2	+	16	1628	c.1442G>A	c.(1441-1443)CGC>CAC	p.R481H	PDGFRA_uc003haa.2_Intron|FIP1L1_uc011bzu.1_Missense_Mutation_p.R475H|FIP1L1_uc003gzz.2_Missense_Mutation_p.R407H|FIP1L1_uc003hab.2_Missense_Mutation_p.R446H|FIP1L1_uc003hac.2_Missense_Mutation_p.R235H|FIP1L1_uc010ign.2_RNA|FIP1L1_uc003had.2_Missense_Mutation_p.A66T|FIP1L1_uc003hae.2_Missense_Mutation_p.A66T	NM_030917	NP_112179	Q6UN15	FIP1_HUMAN	FIP1 like 1 isoform 1	481	Arg-rich.|Sufficient for interaction with CPSF1 and CSTF3.|Glu-rich.				mRNA processing	nucleus	RNA binding			ovary(1)|skin(1)	2			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)					T	PDGFRA	idiopathic hypereosinophilic syndrome								---	---	---	---
CENPC1	1060	broad.mit.edu	37	4	68372572	68372572	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68372572G>T	uc003hdd.1	-	11	2168	c.1985C>A	c.(1984-1986)ACA>AAA	p.T662K	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.T662K	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	662					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2																		---	---	---	---
CENPC1	1060	broad.mit.edu	37	4	68406764	68406764	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68406764G>A	uc003hdd.1	-	3	253	c.70C>T	c.(70-72)CGT>TGT	p.R24C	CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.R24C	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	24					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2																		---	---	---	---
TMPRSS11A	339967	broad.mit.edu	37	4	68788633	68788633	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:68788633G>A	uc003hdr.1	-	7	662	c.541C>T	c.(541-543)CGA>TGA	p.R181*	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Nonsense_Mutation_p.R178*	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	181	Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1																		---	---	---	---
ANKRD17	26057	broad.mit.edu	37	4	73959868	73959868	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:73959868C>T	uc003hgp.2	-	28	5372	c.5255G>A	c.(5254-5256)CGG>CAG	p.R1752Q	ANKRD17_uc003hgo.2_Missense_Mutation_p.R1639Q|ANKRD17_uc003hgq.2_Missense_Mutation_p.R1501Q|ANKRD17_uc003hgr.2_Missense_Mutation_p.R1751Q	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1752	KH.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)															---	---	---	---
MTHFD2L	441024	broad.mit.edu	37	4	75167404	75167404	+	Intron	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:75167404T>C	uc011cbk.1	+						MTHFD2L_uc003hhu.2_Intron|uc003hhv.1_Intron	NM_001144978	NP_001138450			methylenetetrahydrofolate dehydrogenase 2-like						folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			ovary(1)|central_nervous_system(1)	2			all cancers(17;0.0101)|Lung(101;0.196)															---	---	---	---
C4orf26	152816	broad.mit.edu	37	4	76489373	76489373	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:76489373C>T	uc003hip.1	+	2	152	c.117C>T	c.(115-117)GAC>GAT	p.D39D	C4orf26_uc011cbn.1_RNA|C4orf26_uc011cbo.1_Missense_Mutation_p.T54M	NM_178497	NP_848592	Q17RF5	CD026_HUMAN	hypothetical protein LOC152816 precursor	39						extracellular region					0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)															---	---	---	---
FRAS1	80144	broad.mit.edu	37	4	79420976	79420976	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:79420976C>T	uc003hlb.2	+	61	9657	c.9217C>T	c.(9217-9219)CAG>TAG	p.Q3073*	FRAS1_uc003hlc.1_Nonsense_Mutation_p.Q75*	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3068	Calx-beta 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5																		---	---	---	---
BMP3	651	broad.mit.edu	37	4	81967532	81967532	+	Missense_Mutation	SNP	G	T	T	rs61729827	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:81967532G>T	uc003hmg.3	+	2	1277	c.957G>T	c.(955-957)AAG>AAT	p.K319N		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	319					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5																		---	---	---	---
PRKG2	5593	broad.mit.edu	37	4	82031710	82031710	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:82031710C>T	uc003hmh.2	-	14	1846	c.1832G>A	c.(1831-1833)TGT>TAT	p.C611Y	PRKG2_uc011ccf.1_Missense_Mutation_p.C191Y|PRKG2_uc011ccg.1_Missense_Mutation_p.C191Y|PRKG2_uc011cch.1_Missense_Mutation_p.C582Y	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	611	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7																		---	---	---	---
LIN54	132660	broad.mit.edu	37	4	83891596	83891596	+	Missense_Mutation	SNP	C	T	T	rs149250571		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83891596C>T	uc003hnx.3	-	4	1213	c.835G>A	c.(835-837)GGA>AGA	p.G279R	LIN54_uc003hnz.3_Missense_Mutation_p.G58R|LIN54_uc003hny.3_5'UTR|LIN54_uc010ijt.2_Intron|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Missense_Mutation_p.G58R	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	279					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)																---	---	---	---
LIN54	132660	broad.mit.edu	37	4	83905318	83905318	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:83905318A>G	uc003hnx.3	-	2	1058	c.680T>C	c.(679-681)GTA>GCA	p.V227A	LIN54_uc003hnz.3_Intron|LIN54_uc003hny.3_Intron|LIN54_uc010ijt.2_Missense_Mutation_p.V227A|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Intron	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	227					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)																---	---	---	---
HPSE	10855	broad.mit.edu	37	4	84222192	84222192	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:84222192G>A	uc003hoj.3	-	11	1492	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	HPSE_uc010ika.2_Missense_Mutation_p.R407W|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_Missense_Mutation_p.R208W|HPSE_uc011cct.1_Missense_Mutation_p.R391W|HPSE_uc003hok.3_Missense_Mutation_p.R465W	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	465					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)													---	---	---	---
HSD17B11	51170	broad.mit.edu	37	4	88258505	88258505	+	Missense_Mutation	SNP	G	A	A	rs148948833	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:88258505G>A	uc003hqp.2	-	7	1059	c.826C>T	c.(826-828)CGT>TGT	p.R276C		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	276					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)														---	---	---	---
HERC6	55008	broad.mit.edu	37	4	89326069	89326069	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:89326069A>C	uc011cdi.1	+	9	1317	c.1134A>C	c.(1132-1134)GAA>GAC	p.E378D	HERC6_uc011cdj.1_Missense_Mutation_p.E378D|HERC6_uc011cdk.1_Intron|HERC6_uc011cdl.1_Intron	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	378					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)														---	---	---	---
BMPR1B	658	broad.mit.edu	37	4	96069948	96069948	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96069948C>T	uc003htm.3	+	11	1400	c.1126C>T	c.(1126-1128)CGC>TGC	p.R376C	BMPR1B_uc010ilb.2_Missense_Mutation_p.R376C|BMPR1B_uc003htn.3_Missense_Mutation_p.R376C	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	376	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)														---	---	---	---
UNC5C	8633	broad.mit.edu	37	4	96469892	96469892	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:96469892G>A	uc003htp.1	-	1	271	c.117C>T	c.(115-117)GCC>GCT	p.A39A	UNC5C_uc010ilc.1_Silent_p.A39A|UNC5C_uc003htq.2_Silent_p.A39A	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	39					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)														---	---	---	---
SLC39A8	64116	broad.mit.edu	37	4	103189153	103189153	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:103189153C>T	uc003hwb.1	-	6	1453	c.924G>A	c.(922-924)ACG>ACA	p.T308T	SLC39A8_uc011ceo.1_Silent_p.T308T|SLC39A8_uc003hwa.1_Silent_p.T241T|SLC39A8_uc003hwc.2_Silent_p.T308T	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	308	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)														---	---	---	---
CFI	3426	broad.mit.edu	37	4	110667424	110667424	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110667424G>A	uc003hzr.3	-	11	1591	c.1383C>T	c.(1381-1383)TTC>TTT	p.F461F	CFI_uc003hzq.2_Silent_p.F258F|CFI_uc011cft.1_Silent_p.F469F|CFI_uc003hzs.3_Silent_p.F454F	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	461	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)														---	---	---	---
EGF	1950	broad.mit.edu	37	4	110882030	110882030	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:110882030T>C	uc003hzy.3	+	7	1526	c.1074T>C	c.(1072-1074)AAT>AAC	p.N358N	EGF_uc011cfu.1_Silent_p.N316N|EGF_uc011cfv.1_Silent_p.N358N	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	358	EGF-like 2; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)													---	---	---	---
ALPK1	80216	broad.mit.edu	37	4	113351824	113351824	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:113351824C>T	uc003iap.3	+	11	1400	c.1121C>T	c.(1120-1122)ACG>ATG	p.T374M	ALPK1_uc003ian.3_Missense_Mutation_p.T374M|ALPK1_uc011cfx.1_Missense_Mutation_p.T296M|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.T202M	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	374							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)														---	---	---	---
ANK2	287	broad.mit.edu	37	4	114199668	114199668	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:114199668C>T	uc003ibe.3	+	17	1935	c.1835C>T	c.(1834-1836)GCG>GTG	p.A612V	ANK2_uc003ibd.3_Missense_Mutation_p.A591V|ANK2_uc003ibf.3_Missense_Mutation_p.A612V|ANK2_uc003ibc.2_Missense_Mutation_p.A588V|ANK2_uc011cgb.1_Missense_Mutation_p.A627V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	612	ANK 18.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)												OREG0016024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ADAD1	132612	broad.mit.edu	37	4	123342458	123342458	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123342458T>C	uc003ieo.2	+	12	1762	c.1530T>C	c.(1528-1530)TGT>TGC	p.C510C	ADAD1_uc003iep.2_Silent_p.C499C|ADAD1_uc003ieq.2_Silent_p.C492C	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	510	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0																		---	---	---	---
BBS12	166379	broad.mit.edu	37	4	123663986	123663986	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:123663986A>G	uc003ieu.2	+	2	1132	c.939A>G	c.(937-939)TCA>TCG	p.S313S		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	313					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2														Bardet-Biedl_syndrome				---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134071394	134071394	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134071394C>T	uc003iha.2	+	1	925	c.99C>T	c.(97-99)TTC>TTT	p.F33F	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.F33F	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	33	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
PCDH10	57575	broad.mit.edu	37	4	134073108	134073108	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:134073108G>A	uc003iha.2	+	1	2639	c.1813G>A	c.(1813-1815)GCC>ACC	p.A605T	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.A605T	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	605	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)														---	---	---	---
USP38	84640	broad.mit.edu	37	4	144107096	144107096	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144107096A>G	uc003ijb.2	+	1	1027	c.493A>G	c.(493-495)ATC>GTC	p.I165V	USP38_uc003ija.3_Missense_Mutation_p.I165V|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	165					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)																	---	---	---	---
USP38	84640	broad.mit.edu	37	4	144141531	144141531	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144141531C>T	uc003ijb.2	+	10	3585	c.3051C>T	c.(3049-3051)AAC>AAT	p.N1017N	USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	1017					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)																	---	---	---	---
SMARCA5	8467	broad.mit.edu	37	4	144467126	144467126	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:144467126G>A	uc003ijg.2	+	19	2908	c.2446G>A	c.(2446-2448)GAA>AAA	p.E816K		NM_003601	NP_003592	O60264	SMCA5_HUMAN	SWI/SNF-related matrix-associated	816					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding			skin(1)	1	all_hematologic(180;0.158)																	---	---	---	---
HHIP	64399	broad.mit.edu	37	4	145567864	145567864	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145567864G>C	uc003ijs.1	+	1	692	c.37G>C	c.(37-39)GCC>CCC	p.A13P	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_Missense_Mutation_p.A13P	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	13						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)												OREG0016346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
HHIP	64399	broad.mit.edu	37	4	145635449	145635449	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:145635449G>A	uc003ijs.1	+	9	2151	c.1496G>A	c.(1495-1497)GGC>GAC	p.G499D		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	499						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)														---	---	---	---
DCLK2	166614	broad.mit.edu	37	4	151119187	151119187	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151119187C>A	uc003ilm.3	+	4	993	c.893C>A	c.(892-894)TCC>TAC	p.S298Y	DCLK2_uc003iln.3_Missense_Mutation_p.S298Y|DCLK2_uc003ilo.3_Missense_Mutation_p.S298Y|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	298	Ser-rich.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)																	---	---	---	---
LRBA	987	broad.mit.edu	37	4	151770151	151770151	+	Splice_Site	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:151770151C>T	uc010ipj.2	-	26	4633	c.4159_splice	c.e26-1	p.H1387_splice	LRBA_uc003ilt.3_Splice_Site_p.H46_splice|LRBA_uc003ilu.3_Splice_Site_p.H1387_splice	NM_006726	NP_006717			LPS-responsive vesicle trafficking, beach and							endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)																	---	---	---	---
KIAA0922	23240	broad.mit.edu	37	4	154502038	154502038	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:154502038G>A	uc003inm.3	+	8	773	c.721G>A	c.(721-723)GTG>ATG	p.V241M	KIAA0922_uc010ipp.2_Missense_Mutation_p.V241M|KIAA0922_uc010ipq.2_Missense_Mutation_p.V93M	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	241	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)																---	---	---	---
FGB	2244	broad.mit.edu	37	4	155490691	155490691	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:155490691A>C	uc003ioa.3	+	7	1023	c.984A>C	c.(982-984)AAA>AAC	p.K328N	FGB_uc003iob.3_Intron|FGB_uc010ipv.2_Missense_Mutation_p.K266N|FGB_uc010ipw.2_Intron|FGB_uc003ioc.3_Missense_Mutation_p.K109N	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	328	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)													---	---	---	---
FSTL5	56884	broad.mit.edu	37	4	162402250	162402250	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:162402250T>G	uc003iqh.2	-	13	1966	c.1530A>C	c.(1528-1530)AAA>AAC	p.K510N	FSTL5_uc003iqi.2_Missense_Mutation_p.K509N|FSTL5_uc010iqv.2_Missense_Mutation_p.K500N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	510						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)														---	---	---	---
ANXA10	11199	broad.mit.edu	37	4	169105843	169105843	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169105843G>A	uc003irm.2	+						ANXA10_uc003irn.2_Intron	NM_007193	NP_009124			annexin A10								calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)														---	---	---	---
DDX60L	91351	broad.mit.edu	37	4	169337880	169337880	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:169337880G>T	uc003irq.3	-	20	2900	c.2679C>A	c.(2677-2679)CCC>CCA	p.P893P	DDX60L_uc003irr.1_Silent_p.P893P|DDX60L_uc003irs.1_Silent_p.P588P	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	893	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)														---	---	---	---
NEIL3	55247	broad.mit.edu	37	4	178283483	178283483	+	Missense_Mutation	SNP	G	A	A	rs149552701	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:178283483G>A	uc003iut.2	+	10	1793	c.1676G>A	c.(1675-1677)CGT>CAT	p.R559H		NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	559					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)									BER_DNA_glycosylases					---	---	---	---
LOC285501	285501	broad.mit.edu	37	4	178911667	178911667	+	RNA	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:178911667A>G	uc010iru.2	+	6		c.801A>G				NR_028342				Homo sapiens cDNA clone IMAGE:4828874.												0		all_lung(41;6.03e-08)|Lung NSC(41;4.26e-07)|Breast(14;0.00066)|Melanoma(52;0.00168)|Prostate(90;0.0129)|all_hematologic(60;0.0202)|Renal(120;0.0246)|Colorectal(36;0.0508)|Hepatocellular(41;0.236)		all cancers(43;9.24e-25)|Epithelial(43;6.28e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.29e-10)|LUSC - Lung squamous cell carcinoma(1;2.61e-05)|Lung(1;3.22e-05)|GBM - Glioblastoma multiforme(59;0.000185)|Colorectal(24;0.000244)|STAD - Stomach adenocarcinoma(60;0.000777)|COAD - Colon adenocarcinoma(29;0.000884)														---	---	---	---
HELT	391723	broad.mit.edu	37	4	185940872	185940872	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185940872G>A	uc011ckq.1	+	3	359	c.359G>A	c.(358-360)CGC>CAC	p.R120H	HELT_uc011cko.1_Intron|HELT_uc003ixa.3_Intron|HELT_uc011ckp.1_5'UTR	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	120	Helix-loop-helix motif.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)														---	---	---	---
HELT	391723	broad.mit.edu	37	4	185941544	185941544	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:185941544C>T	uc011ckq.1	+	4	602	c.602C>T	c.(601-603)GCG>GTG	p.A201V	HELT_uc011cko.1_Missense_Mutation_p.A116V|HELT_uc003ixa.3_Missense_Mutation_p.A115V|HELT_uc011ckp.1_Missense_Mutation_p.A59V	NM_001029887	NP_001025058	A6NFD8	HELT_HUMAN	HES/HEY-like transcription factor	201	Orange.						DNA binding				0		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;8.92e-26)|Epithelial(43;3.02e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.59e-11)|Colorectal(24;4.79e-05)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000274)|COAD - Colon adenocarcinoma(29;0.000362)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)														---	---	---	---
TRIML2	205860	broad.mit.edu	37	4	189012847	189012847	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr4:189012847C>T	uc003izl.2	-	7	880	c.844G>A	c.(844-846)GCC>ACC	p.A282T	TRIML2_uc003izj.1_Missense_Mutation_p.A110T|TRIML2_uc003izk.1_Missense_Mutation_p.A90T|TRIML2_uc011cle.1_Missense_Mutation_p.A357T	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	282	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)														---	---	---	---
BRD9	65980	broad.mit.edu	37	5	884073	884073	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:884073G>A	uc003jbq.2	-	8	1113	c.946C>T	c.(946-948)CGG>TGG	p.R316W	BRD9_uc003jbl.2_Missense_Mutation_p.R200W|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Missense_Mutation_p.R263W|BRD9_uc003jbo.2_Missense_Mutation_p.R220W|BRD9_uc003jbp.2_5'Flank|BRD9_uc011cmc.1_RNA	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	316							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)															---	---	---	---
SLC12A7	10723	broad.mit.edu	37	5	1076892	1076892	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1076892C>T	uc003jbu.2	-	13	1731	c.1665G>A	c.(1663-1665)ACG>ACA	p.T555T		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	555	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)													---	---	---	---
SLC12A7	10723	broad.mit.edu	37	5	1081834	1081834	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:1081834G>A	uc003jbu.2	-	9	1221	c.1155C>T	c.(1153-1155)CAC>CAT	p.H385H		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	385					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)													---	---	---	---
IRX1	79192	broad.mit.edu	37	5	3599423	3599423	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:3599423G>A	uc003jde.2	+	2	413	c.361G>A	c.(361-363)GGC>AGC	p.G121S		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	121						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2																		---	---	---	---
KIAA0947	23379	broad.mit.edu	37	5	5462807	5462807	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:5462807C>T	uc003jdm.3	+	13	3582	c.3360C>T	c.(3358-3360)AGC>AGT	p.S1120S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1120										ovary(1)|central_nervous_system(1)	2																		---	---	---	---
MYO10	4651	broad.mit.edu	37	5	16769228	16769228	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:16769228T>C	uc003jft.3	-	10	1483	c.1015A>G	c.(1015-1017)ATA>GTA	p.I339V	MYO10_uc010itx.2_5'Flank	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	339	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3																		---	---	---	---
CDH9	1007	broad.mit.edu	37	5	26885740	26885740	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:26885740C>T	uc003jgs.1	-	11	2034	c.1865G>A	c.(1864-1866)TGT>TAT	p.C622Y	CDH9_uc011cnv.1_Missense_Mutation_p.C215Y	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	622	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9																		---	---	---	---
NIPBL	25836	broad.mit.edu	37	5	37045566	37045566	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:37045566G>A	uc003jkl.3	+	37	6864	c.6365G>A	c.(6364-6366)AGT>AAT	p.S2122N	NIPBL_uc003jkk.3_Missense_Mutation_p.S2122N	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2122					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)															---	---	---	---
EGFLAM	133584	broad.mit.edu	37	5	38350644	38350644	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:38350644T>C	uc003jlc.1	+	4	657	c.333T>C	c.(331-333)CGT>CGC	p.R111R	EGFLAM_uc003jlb.1_Silent_p.R111R	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	111	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)																	---	---	---	---
PLCXD3	345557	broad.mit.edu	37	5	41382192	41382192	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:41382192T>C	uc003jmm.1	-	2	650	c.548A>G	c.(547-549)TAC>TGC	p.Y183C		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	183	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6																		---	---	---	---
MGC42105	167359	broad.mit.edu	37	5	43280659	43280659	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:43280659G>A	uc003jno.2	+	4	2020	c.1139G>A	c.(1138-1140)CGC>CAC	p.R380H		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	380							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9																		---	---	---	---
FGF10	2255	broad.mit.edu	37	5	44388639	44388639	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:44388639G>A	uc003jog.1	-	1	146	c.146C>T	c.(145-147)GCC>GTC	p.A49V		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	49					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)																	---	---	---	---
HCN1	348980	broad.mit.edu	37	5	45645327	45645327	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:45645327C>T	uc003jok.2	-	2	834	c.809G>A	c.(808-810)CGA>CAA	p.R270Q		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	270	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1																		---	---	---	---
PARP8	79668	broad.mit.edu	37	5	50059056	50059056	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:50059056G>A	uc003jon.3	+	8	680	c.498G>A	c.(496-498)GGG>GGA	p.G166G	PARP8_uc011cpz.1_Silent_p.G58G|PARP8_uc003joo.2_Silent_p.G166G|PARP8_uc003jop.2_Silent_p.G166G	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	166						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)																---	---	---	---
IL6ST	3572	broad.mit.edu	37	5	55247315	55247315	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:55247315A>G	uc003jqq.2	-	14	2072	c.1817T>C	c.(1816-1818)TTC>TCC	p.F606S	IL6ST_uc010iwb.2_Missense_Mutation_p.F545S|IL6ST_uc010iwc.2_Intron|IL6ST_uc010iwd.2_Intron|IL6ST_uc011cqk.1_Missense_Mutation_p.F317S|IL6ST_uc003jqr.2_3'UTR|IL6ST_uc010iwe.1_RNA	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	606	Extracellular (Potential).|Fibronectin type-III 5.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)						O		hepatocellular ca								---	---	---	---
DEPDC1B	55789	broad.mit.edu	37	5	59982801	59982801	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:59982801C>T	uc003jsh.2	-	2	375	c.302G>A	c.(301-303)CGT>CAT	p.R101H	DEPDC1B_uc011cqm.1_Missense_Mutation_p.R101H|DEPDC1B_uc011cqn.1_Missense_Mutation_p.R74H	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	101	DEP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)																---	---	---	---
MAST4	375449	broad.mit.edu	37	5	66430427	66430427	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:66430427C>T	uc003jut.1	+	17	1804	c.1736C>T	c.(1735-1737)GCC>GTC	p.A579V	MAST4_uc003juu.1_Missense_Mutation_p.A589V|MAST4_uc011cra.1_Missense_Mutation_p.A562V|MAST4_uc003juv.2_Missense_Mutation_p.A574V|MAST4_uc003juw.2_Missense_Mutation_p.A574V	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	771	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)														---	---	---	---
ZNF366	167465	broad.mit.edu	37	5	71756601	71756601	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:71756601G>A	uc003kce.1	-	2	909	c.723C>T	c.(721-723)AGC>AGT	p.S241S		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	241					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)														---	---	---	---
POLK	51426	broad.mit.edu	37	5	74892070	74892070	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:74892070A>G	uc003kdw.2	+	13	1648	c.1552A>G	c.(1552-1554)AAT>GAT	p.N518D	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.N320D|POLK_uc003kec.2_Missense_Mutation_p.N428D|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.N428D	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	518					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)									DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					---	---	---	---
ZFYVE16	9765	broad.mit.edu	37	5	79734068	79734068	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:79734068G>A	uc003kgr.3	+	4	1866	c.1564G>A	c.(1564-1566)GCA>ACA	p.A522T	ZFYVE16_uc010jak.1_Missense_Mutation_p.A522T|ZFYVE16_uc003kgp.2_Missense_Mutation_p.A522T|ZFYVE16_uc003kgq.3_Missense_Mutation_p.A522T|ZFYVE16_uc003kgs.3_Missense_Mutation_p.A522T	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	522					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)														---	---	---	---
XRCC4	7518	broad.mit.edu	37	5	82491728	82491728	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82491728T>C	uc003kib.2	+	4	583	c.455T>C	c.(454-456)CTG>CCG	p.L152P	XRCC4_uc003kia.1_Missense_Mutation_p.L152P|XRCC4_uc003kid.2_Missense_Mutation_p.L152P|XRCC4_uc003kic.2_Missense_Mutation_p.L152P|XRCC4_uc003kie.2_Missense_Mutation_p.L152P|XRCC4_uc003kif.1_Missense_Mutation_p.L152P	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	152	Potential.				DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)									NHEJ					---	---	---	---
HAPLN1	1404	broad.mit.edu	37	5	82937478	82937478	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:82937478T>C	uc003kim.2	-	4	973	c.902A>G	c.(901-903)TAT>TGT	p.Y301C	HAPLN1_uc003kin.2_Missense_Mutation_p.Y301C	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	301	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)														---	---	---	---
GPR98	84059	broad.mit.edu	37	5	89990228	89990228	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:89990228C>T	uc003kju.2	+	33	7751	c.7655C>T	c.(7654-7656)GCC>GTC	p.A2552V	GPR98_uc003kjt.2_Missense_Mutation_p.A258V|GPR98_uc003kjv.2_Missense_Mutation_p.A152V	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2552	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)														---	---	---	---
ARRDC3	57561	broad.mit.edu	37	5	90672541	90672541	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:90672541T>C	uc003kjz.2	-	3	647	c.407A>G	c.(406-408)TAT>TGT	p.Y136C		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	136					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)														---	---	---	---
RHOBTB3	22836	broad.mit.edu	37	5	95119538	95119538	+	Silent	SNP	C	T	T	rs150008155		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:95119538C>T	uc003klm.2	+	10	2031	c.1494C>T	c.(1492-1494)GCC>GCT	p.A498A		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	498	Interaction with Rab9.			A->T: Abolishes interaction with RAB9A.	retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)														---	---	---	---
ELL2	22936	broad.mit.edu	37	5	95249514	95249514	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:95249514G>A	uc003klr.3	-	4	792	c.442C>T	c.(442-444)CGA>TGA	p.R148*		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	148					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)														---	---	---	---
SLCO6A1	133482	broad.mit.edu	37	5	101834536	101834536	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:101834536C>T	uc003knn.2	-	1	185	c.13G>A	c.(13-15)GTC>ATC	p.V5I	SLCO6A1_uc003kno.2_Missense_Mutation_p.V5I|SLCO6A1_uc003knp.2_Missense_Mutation_p.V5I|SLCO6A1_uc003knq.2_Missense_Mutation_p.V5I	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	5	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)														---	---	---	---
MCC	4163	broad.mit.edu	37	5	112478910	112478910	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:112478910C>T	uc003kqj.3	-						MCC_uc003kqk.3_Intron|MCC_uc003kql.3_Intron|MCC_uc011cwb.1_Intron|MCC_uc010jcd.1_Intron	NM_002387	NP_002378			mutated in colorectal cancers isoform 2						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)														---	---	---	---
COMMD10	51397	broad.mit.edu	37	5	115426820	115426820	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:115426820G>A	uc003krt.1	+	3	200	c.177G>A	c.(175-177)GCG>GCA	p.A59A		NM_016144	NP_057228	Q9Y6G5	COMDA_HUMAN	COMM domain containing 10	59							protein binding			ovary(1)	1		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)														---	---	---	---
DMXL1	1657	broad.mit.edu	37	5	118500337	118500337	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:118500337G>A	uc003ksd.2	+	20	5019	c.4838G>A	c.(4837-4839)CGG>CAG	p.R1613Q	DMXL1_uc010jcl.1_Missense_Mutation_p.R1613Q	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1613										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)														---	---	---	---
FBN2	2201	broad.mit.edu	37	5	127681104	127681104	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:127681104G>A	uc003kuu.2	-	24	3601	c.3162C>T	c.(3160-3162)CGC>CGT	p.R1054R	FBN2_uc003kuv.2_Silent_p.R1021R	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1054					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)														---	---	---	---
C5orf20	140947	broad.mit.edu	37	5	134782379	134782379	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:134782379C>T	uc003lav.2	-	1	660	c.420G>A	c.(418-420)CCG>CCA	p.P140P		NM_130848	NP_570900	Q8TF63	DCNP1_HUMAN	dendritic cell nuclear protein 1	140						nucleus					0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)															---	---	---	---
KIF20A	10112	broad.mit.edu	37	5	137520324	137520324	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:137520324G>A	uc003lcj.2	+	13	2138	c.1642G>A	c.(1642-1644)GAT>AAT	p.D548N	KIF20A_uc011cyo.1_Missense_Mutation_p.D530N	NM_005733	NP_005724	O95235	KI20A_HUMAN	kinesin family member 20A	548					cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)															---	---	---	---
CTNNA1	1495	broad.mit.edu	37	5	138260288	138260288	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:138260288C>T	uc003ldh.2	+	12	1731	c.1636C>T	c.(1636-1638)CGA>TGA	p.R546*	CTNNA1_uc011cyx.1_Nonsense_Mutation_p.R443*|CTNNA1_uc011cyy.1_Nonsense_Mutation_p.R423*|CTNNA1_uc003ldi.2_Nonsense_Mutation_p.R244*|CTNNA1_uc003ldj.2_Nonsense_Mutation_p.R546*|CTNNA1_uc003ldl.2_Nonsense_Mutation_p.R176*	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	546					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)															---	---	---	---
PCDHA9	9752	broad.mit.edu	37	5	140229215	140229215	+	Missense_Mutation	SNP	G	A	A	rs151053430	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140229215G>A	uc003lhu.2	+	1	1859	c.1135G>A	c.(1135-1137)GCA>ACA	p.A379T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A379T	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	379	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHAC2	56134	broad.mit.edu	37	5	140346986	140346986	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140346986G>A	uc003lii.2	+	1	875	c.635G>A	c.(634-636)CGT>CAT	p.R212H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Missense_Mutation_p.R212H	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	212	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHB8	56128	broad.mit.edu	37	5	140559234	140559234	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140559234C>T	uc011dai.1	+	1	1805	c.1619C>T	c.(1618-1620)CCG>CTG	p.P540L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB9	56127	broad.mit.edu	37	5	140567405	140567405	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140567405G>A	uc003liw.1	+	1	513	c.513G>A	c.(511-513)ACG>ACA	p.T171T		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	171	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHB12	56124	broad.mit.edu	37	5	140589805	140589805	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140589805C>T	uc003liz.2	+	1	1515	c.1326C>T	c.(1324-1326)TCC>TCT	p.S442S	PCDHB12_uc011dak.1_Silent_p.S105S	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	442	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)															---	---	---	---
PCDHGA1	56114	broad.mit.edu	37	5	140712070	140712070	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140712070C>T	uc003lji.1	+	1	1819	c.1819C>T	c.(1819-1821)CGC>TGC	p.R607C	PCDHGA1_uc011dan.1_Missense_Mutation_p.R607C	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	607	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA5	56110	broad.mit.edu	37	5	140743963	140743963	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140743963G>A	uc003lju.1	+	1	66	c.66G>A	c.(64-66)ACG>ACA	p.T22T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.T22T	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	22					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA5	56110	broad.mit.edu	37	5	140745966	140745966	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140745966C>T	uc003lju.1	+	1	2069	c.2069C>T	c.(2068-2070)ACA>ATA	p.T690I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.T690I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	690	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA7	56108	broad.mit.edu	37	5	140763024	140763024	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140763024C>T	uc003lka.1	+	1	558	c.558C>T	c.(556-558)GAC>GAT	p.D186D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.D186D	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	186	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGA7	56108	broad.mit.edu	37	5	140763850	140763850	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140763850G>A	uc003lka.1	+	1	1384	c.1384G>A	c.(1384-1386)GCT>ACT	p.A462T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.A462T	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	462	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
PCDHGB5	56101	broad.mit.edu	37	5	140779486	140779486	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:140779486G>A	uc003lkf.1	+	1	1792	c.1792G>A	c.(1792-1794)GCC>ACC	p.A598T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.A598T	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	598	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
SH3TC2	79628	broad.mit.edu	37	5	148407373	148407373	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:148407373C>T	uc003lpu.2	-	11	2074	c.1922G>A	c.(1921-1923)CGC>CAC	p.R641H	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc010jgw.2_Missense_Mutation_p.R285H|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_Missense_Mutation_p.R188H|SH3TC2_uc010jgx.2_Missense_Mutation_p.R634H|SH3TC2_uc003lpv.1_Missense_Mutation_p.R188H|SH3TC2_uc011dbz.1_Missense_Mutation_p.R526H	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	641							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)															---	---	---	---
FAT2	2196	broad.mit.edu	37	5	150905459	150905459	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:150905459C>G	uc003lue.3	-	17	10389	c.10376G>C	c.(10375-10377)GGC>GCC	p.G3459A	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.G152A	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3459	Extracellular (Potential).|Cadherin 31.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)															---	---	---	---
NIPAL4	348938	broad.mit.edu	37	5	156899809	156899809	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:156899809C>T	uc003lwx.3	+	6	1358	c.1242C>T	c.(1240-1242)TGC>TGT	p.C414C	ADAM19_uc003lww.1_Intron|NIPAL4_uc011ddq.1_Silent_p.C395C	NM_001099287	NP_001092757	Q0D2K0	NIPA4_HUMAN	ichthyin protein	414	Cytoplasmic (Potential).					integral to membrane	receptor activity				0																		---	---	---	---
ATP10B	23120	broad.mit.edu	37	5	160076269	160076269	+	Intron	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:160076269A>T	uc003lym.1	-						ATP10B_uc003lyp.2_Intron|ATP10B_uc011deg.1_Intron|ATP10B_uc003lyo.2_Intron	NM_025153	NP_079429			ATPase, class V, type 10B						ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)															---	---	---	---
FBLL1	345630	broad.mit.edu	37	5	167957455	167957455	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:167957455C>T	uc011dep.1	+	1	874	c.661C>T	c.(661-663)CGG>TGG	p.R221W		NR_024356				RecName: Full=rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1;          EC=2.1.1.-;												0																		---	---	---	---
TLX3	30012	broad.mit.edu	37	5	170736618	170736618	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:170736618G>A	uc003mbf.2	+	1	331	c.249G>A	c.(247-249)GCG>GCA	p.A83A	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	83						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)					T	BCL11B	T-ALL								---	---	---	---
FGFR4	2264	broad.mit.edu	37	5	176522651	176522651	+	Missense_Mutation	SNP	C	T	T	rs138800021	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176522651C>T	uc003mfl.2	+	13	1915	c.1748C>T	c.(1747-1749)CCG>CTG	p.P583L	FGFR4_uc003mfm.2_Missense_Mutation_p.P583L|FGFR4_uc011dfu.1_Missense_Mutation_p.P515L|FGFR4_uc003mfo.2_Missense_Mutation_p.P543L	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	583	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)										TSP Lung(9;0.080)			---	---	---	---
NSD1	64324	broad.mit.edu	37	5	176631302	176631302	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176631302C>T	uc003mfr.3	+						NSD1_uc003mft.3_Intron|NSD1_uc003mfs.1_Intron|NSD1_uc011dfx.1_Intron	NM_022455	NP_071900			nuclear receptor binding SET domain protein 1						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)				T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			---	---	---	---
LMAN2	10960	broad.mit.edu	37	5	176759221	176759221	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176759221A>C	uc003mge.2	-	8	1174	c.937T>G	c.(937-939)TTC>GTC	p.F313V	LMAN2_uc003mgd.2_Silent_p.T320T	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	313	Lumenal (Potential).				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
DBN1	1627	broad.mit.edu	37	5	176886118	176886118	+	Silent	SNP	C	T	T	rs139033012		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:176886118C>T	uc003mgy.2	-	11	1279	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P	DBN1_uc011dga.1_Silent_p.P101P|DBN1_uc003mgx.2_Silent_p.P371P|DBN1_uc010jkn.1_Silent_p.P319P|DBN1_uc003mgz.1_Silent_p.P352P	NM_004395	NP_004386	Q16643	DREB_HUMAN	drebrin 1 isoform a	369					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|ovary(1)|lung(1)|skin(1)	6	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
TBC1D9B	23061	broad.mit.edu	37	5	179315143	179315143	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:179315143A>G	uc003mlh.2	-	7	1251	c.1214T>C	c.(1213-1215)ATC>ACC	p.I405T	TBC1D9B_uc003mli.2_Missense_Mutation_p.I405T|TBC1D9B_uc003mlj.2_Missense_Mutation_p.I405T	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	405						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
FLT4	2324	broad.mit.edu	37	5	180030183	180030183	+	3'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180030183C>T	uc003mlz.3	-	30						NM_182925	NP_891555			fms-related tyrosine kinase 4 isoform 1						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)									Congenital_Hereditary_Lymphedema				---	---	---	---
MGAT1	4245	broad.mit.edu	37	5	180219454	180219454	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr5:180219454G>A	uc003mmg.3	-	2	1013	c.518C>T	c.(517-519)CCG>CTG	p.P173L	MGAT1_uc010jlf.2_Missense_Mutation_p.P173L|MGAT1_uc010jlg.2_Missense_Mutation_p.P173L|MGAT1_uc003mmh.3_Missense_Mutation_p.P173L|MGAT1_uc010jlh.2_Missense_Mutation_p.P173L|MGAT1_uc003mmi.3_Missense_Mutation_p.P173L	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	173	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)															---	---	---	---
NQO2	4835	broad.mit.edu	37	6	3017128	3017128	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:3017128C>T	uc003mus.2	+	6	766	c.428C>T	c.(427-429)GCG>GTG	p.A143V	NQO2_uc003mut.2_Missense_Mutation_p.A143V	NM_000904	NP_000895	P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2	143						cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			ovary(1)	1	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)													---	---	---	---
BPHL	670	broad.mit.edu	37	6	3137678	3137678	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:3137678C>A	uc003mva.2	+	5	664	c.615C>A	c.(613-615)ACC>ACA	p.T205T	BPHL_uc003muz.2_Intron|BPHL_uc011dht.1_Intron|BPHL_uc003muy.2_Silent_p.T188T	NM_004332	NP_004323	Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like precursor	205					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity				0	Ovarian(93;0.0386)	all_hematologic(90;0.108)																---	---	---	---
NRN1	51299	broad.mit.edu	37	6	5999288	5999288	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:5999288G>A	uc003mwu.2	-	3	1001	c.350C>T	c.(349-351)GCG>GTG	p.A117V	NRN1_uc003mwt.2_Missense_Mutation_p.A143V	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	117						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)														---	---	---	---
NEDD9	4739	broad.mit.edu	37	6	11191156	11191156	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:11191156C>T	uc003mzv.2	-	5	1113	c.946G>A	c.(946-948)GCA>ACA	p.A316T	NEDD9_uc010joz.2_Missense_Mutation_p.A316T|NEDD9_uc003mzw.3_Missense_Mutation_p.A170T	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	316					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)															---	---	---	---
PHACTR1	221692	broad.mit.edu	37	6	13160486	13160486	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13160486C>T	uc010jpc.2	+	6	798	c.466C>T	c.(466-468)CGA>TGA	p.R156*	PHACTR1_uc011dir.1_Nonsense_Mutation_p.R156*|PHACTR1_uc003nag.1_Nonsense_Mutation_p.R156*|PHACTR1_uc003nah.1_Nonsense_Mutation_p.R156*	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	156	RPEL 1.					cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)															---	---	---	---
RANBP9	10048	broad.mit.edu	37	6	13644899	13644899	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:13644899C>T	uc003nbb.2	-	6	1049	c.990G>A	c.(988-990)GGG>GGA	p.G330G	RANBP9_uc003nba.2_5'UTR	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	330	B30.2/SPRY.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)															---	---	---	---
FAM65B	9750	broad.mit.edu	37	6	24843662	24843662	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:24843662A>G	uc003neo.1	-	14	1524	c.1348T>C	c.(1348-1350)TCC>CCC	p.S450P	FAM65B_uc011djs.1_Missense_Mutation_p.S429P|FAM65B_uc011dju.1_Missense_Mutation_p.S434P|FAM65B_uc003nep.2_Missense_Mutation_p.S400P|FAM65B_uc011djt.1_Missense_Mutation_p.S400P	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	450					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1																		---	---	---	---
LRRC16A	55604	broad.mit.edu	37	6	25581667	25581667	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:25581667G>A	uc011djw.1	+	31	3382	c.3006G>A	c.(3004-3006)GCG>GCA	p.A1002A	LRRC16A_uc010jpx.2_Silent_p.A1002A|LRRC16A_uc010jpy.2_Silent_p.A1002A	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1002	Inhibits capping activity of CAPZA2 (By similarity).				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
HIST1H3F	8968	broad.mit.edu	37	6	26250607	26250607	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26250607G>A	uc003nhg.1	-	1	229	c.227C>T	c.(226-228)GCG>GTG	p.A76V	HIST1H2BH_uc003nhh.2_5'Flank	NM_021018	NP_066298	P68431	H31_HUMAN	histone cluster 1, H3f	76					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0																OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZNF322A	79692	broad.mit.edu	37	6	26637632	26637632	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:26637632T>C	uc003nil.3	-	4	1779	c.1150A>G	c.(1150-1152)AGT>GGT	p.S384G	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
HIST1H1B	3009	broad.mit.edu	37	6	27834647	27834647	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:27834647C>T	uc003njx.2	-	1	713	c.661G>A	c.(661-663)GCG>ACG	p.A221T		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	221					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3																		---	---	---	---
TRIM27	5987	broad.mit.edu	37	6	28872085	28872085	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:28872085C>T	uc003nlr.2	-	8	1663	c.1304G>A	c.(1303-1305)CGG>CAG	p.R435Q	TRIM27_uc003nls.2_Intron|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	435	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1								T	RET	papillary thyroid								---	---	---	---
OR2J3	442186	broad.mit.edu	37	6	29080104	29080104	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:29080104T>C	uc011dll.1	+	1	437	c.437T>C	c.(436-438)CTG>CCG	p.L146P		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
PPP1R11	6992	broad.mit.edu	37	6	30036995	30036995	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30036995G>A	uc003npb.2	+	3	549	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	PPP1R11_uc010jrw.2_RNA|PPP1R11_uc003npc.2_RNA	NM_021959	NP_068778	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor)	98						soluble fraction	protein binding|protein phosphatase inhibitor activity			ovary(1)|lung(1)|skin(1)	3																		---	---	---	---
C6orf134	79969	broad.mit.edu	37	6	30608312	30608312	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:30608312G>A	uc003nqu.2	+	8	634	c.584G>A	c.(583-585)CGG>CAG	p.R195Q	C6orf134_uc003nqr.3_Missense_Mutation_p.R195Q|C6orf134_uc003rdc.2_Missense_Mutation_p.R195Q|C6orf134_uc003nqs.3_Intron|C6orf134_uc003rdd.2_Intron|C6orf134_uc003nqt.2_RNA|C6orf134_uc011dmm.1_Intron|C6orf134_uc003nqv.2_Missense_Mutation_p.R183Q	NM_024909	NP_079185	Q5SQI0	ATAT_HUMAN	hypothetical protein LOC79969 isoform 2	195							tubulin N-acetyltransferase activity				0																		---	---	---	---
BAT2	7916	broad.mit.edu	37	6	31595599	31595599	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31595599C>T	uc003nvb.3	+	12	1597	c.1348C>T	c.(1348-1350)CGG>TGG	p.R450W	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.R450W	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	450	4 X 57 AA type A repeats.|2 X type B repeats.					cytoplasm|nucleus	protein binding				0																		---	---	---	---
RDBP	7936	broad.mit.edu	37	6	31924611	31924611	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:31924611T>C	uc003nyk.2	-	4	354	c.150A>G	c.(148-150)CTA>CTG	p.L50L	RDBP_uc011dot.1_Silent_p.L50L|RDBP_uc003nyl.1_5'UTR|RDBP_uc003nym.1_Silent_p.L50L|SKIV2L_uc003nyn.1_5'Flank|SKIV2L_uc011dou.1_5'Flank|SKIV2L_uc011dov.1_5'Flank	NM_002904	NP_002895	P18615	NELFE_HUMAN	RD RNA-binding protein	50					positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	mitochondrion|nucleoplasm	nucleotide binding|protein binding|RNA binding				0																		---	---	---	---
TNXB	7148	broad.mit.edu	37	6	32024489	32024489	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:32024489G>A	uc003nzl.2	-	23	8219	c.8017C>T	c.(8017-8019)CGG>TGG	p.R2673W		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2733	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0																		---	---	---	---
B3GALT4	8705	broad.mit.edu	37	6	33245893	33245893	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:33245893C>T	uc003odr.2	+	1	977	c.697C>T	c.(697-699)CGC>TGC	p.R233C		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	233	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2																		---	---	---	---
C6orf1	221491	broad.mit.edu	37	6	34214308	34214308	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:34214308G>A	uc003ojf.2	-	5	1055	c.463C>T	c.(463-465)CAC>TAC	p.H155Y	uc003oje.1_5'Flank|C6orf1_uc003ojg.2_Missense_Mutation_p.H155Y|C6orf1_uc003ojh.2_Missense_Mutation_p.H155Y|C6orf1_uc003oji.2_RNA	NM_178508	NP_848603	Q86T20	CF001_HUMAN	hypothetical protein LOC221491 precursor	155						extracellular region					0		Ovarian(999;0.0228)		BRCA - Breast invasive adenocarcinoma(397;1.11e-10)														---	---	---	---
PPARD	5467	broad.mit.edu	37	6	35392251	35392251	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:35392251G>A	uc003okm.2	+	7	1082	c.773G>A	c.(772-774)CGG>CAG	p.R258Q	PPARD_uc003okl.2_Missense_Mutation_p.R258Q|PPARD_uc003okn.2_Missense_Mutation_p.R258Q|PPARD_uc011dtb.1_Missense_Mutation_p.R219Q|PPARD_uc011dtc.1_Missense_Mutation_p.R160Q	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	258	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)													---	---	---	---
CPNE5	57699	broad.mit.edu	37	6	36733117	36733117	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:36733117G>A	uc003omr.1	-	11	841	c.774C>T	c.(772-774)GAC>GAT	p.D258D	CPNE5_uc003oms.1_Silent_p.D237D	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	258	C2 2.									skin(1)	1																		---	---	---	---
BTBD9	114781	broad.mit.edu	37	6	38562036	38562036	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38562036C>T	uc003ooa.3	-	4	829	c.253G>A	c.(253-255)GCA>ACA	p.A85T	BTBD9_uc003ony.3_Missense_Mutation_p.A17T|BTBD9_uc010jwv.2_Missense_Mutation_p.A17T|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.A85T	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	85	BTB.				cell adhesion						0																		---	---	---	---
DNAH8	1769	broad.mit.edu	37	6	38754702	38754702	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:38754702T>A	uc003ooe.1	+	16	2506	c.1906T>A	c.(1906-1908)TTG>ATG	p.L636M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21																		---	---	---	---
KIF6	221458	broad.mit.edu	37	6	39507819	39507819	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:39507819G>A	uc003oot.2	-	13	1700	c.1605C>T	c.(1603-1605)AGC>AGT	p.S535S	KIF6_uc010jwz.1_5'UTR|KIF6_uc010jxa.1_Silent_p.S326S|KIF6_uc011dua.1_Silent_p.S535S|KIF6_uc010jxb.1_Intron	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	535					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3																		---	---	---	---
TDRD6	221400	broad.mit.edu	37	6	46661723	46661723	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:46661723G>A	uc003oyj.2	+	1	5858	c.5858G>A	c.(5857-5859)CGC>CAC	p.R1953H	TDRD6_uc010jze.2_Missense_Mutation_p.R1947H	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1953					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)															---	---	---	---
TNFRSF21	27242	broad.mit.edu	37	6	47202394	47202394	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47202394C>T	uc003oyv.2	-							NM_014452	NP_055267			tumor necrosis factor receptor superfamily,						cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)															---	---	---	---
GPR115	221393	broad.mit.edu	37	6	47682279	47682279	+	Missense_Mutation	SNP	C	T	T	rs146828294	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:47682279C>T	uc003oza.1	+	6	1556	c.1298C>T	c.(1297-1299)ACG>ATG	p.T433M	GPR115_uc003oyz.1_Missense_Mutation_p.T490M|GPR115_uc003ozb.1_Missense_Mutation_p.T431M	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	433	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8																		---	---	---	---
TFAP2D	83741	broad.mit.edu	37	6	50682856	50682856	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:50682856C>T	uc003paf.2	+	2	579	c.67C>T	c.(67-69)CGT>TGT	p.R23C	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	23							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)																	---	---	---	---
PKHD1	5314	broad.mit.edu	37	6	51524188	51524188	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:51524188A>G	uc003pah.1	-	61	11012	c.10736T>C	c.(10735-10737)GTA>GCA	p.V3579A		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3579	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)																	---	---	---	---
DST	667	broad.mit.edu	37	6	56473302	56473302	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:56473302G>A	uc003pdf.2	-						DST_uc003pcz.3_Intron|DST_uc011dxj.1_Intron|DST_uc011dxk.1_Intron|DST_uc003pcy.3_Intron|DST_uc003pdb.2_Missense_Mutation_p.R1505C	NM_001144769	NP_001138241			dystonin isoform 2						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)															---	---	---	---
ZNF451	26036	broad.mit.edu	37	6	57012447	57012447	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:57012447G>A	uc003pdm.1	+	10	1788	c.1564G>A	c.(1564-1566)GGA>AGA	p.G522R	ZNF451_uc003pdl.2_Missense_Mutation_p.G522R|ZNF451_uc003pdn.1_Missense_Mutation_p.G522R|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.G522R	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	522					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)															---	---	---	---
COL9A1	1297	broad.mit.edu	37	6	70990735	70990735	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:70990735C>T	uc003pfg.3	-	9	1043	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	COL9A1_uc003pfe.3_5'Flank|COL9A1_uc003pff.3_Missense_Mutation_p.R52Q	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	295	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4																		---	---	---	---
FAM135A	57579	broad.mit.edu	37	6	71248027	71248027	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:71248027G>A	uc003pfj.2	+	18	4284	c.4151G>A	c.(4150-4152)GGT>GAT	p.G1384D	FAM135A_uc003pfi.2_Missense_Mutation_p.G1188D|FAM135A_uc003pfh.2_Missense_Mutation_p.G1171D|FAM135A_uc003pfl.2_Missense_Mutation_p.G1051D|FAM135A_uc003pfn.2_Missense_Mutation_p.G590D|FAM135A_uc003pfo.1_Missense_Mutation_p.G755D|FAM135A_uc010kan.1_Intron	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	1384										central_nervous_system(1)	1																		---	---	---	---
KHDC1	80759	broad.mit.edu	37	6	73952206	73952206	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:73952206G>A	uc003pgo.2	-	3	755	c.254C>T	c.(253-255)CCG>CTG	p.P85L	KHDC1_uc011dyl.1_RNA|KHDC1_uc003pgn.3_Missense_Mutation_p.P12L	NM_030568	NP_085045	Q4VXA5	KHDC1_HUMAN	KH homology domain containing 1	85						integral to membrane	RNA binding			skin(1)	1																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75853032	75853032	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75853032G>T	uc003phs.2	-	26	4929	c.4763C>A	c.(4762-4764)CCT>CAT	p.P1588H	COL12A1_uc003pht.2_Missense_Mutation_p.P424H	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1588	Fibronectin type-III 11.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
COL12A1	1303	broad.mit.edu	37	6	75861886	75861886	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:75861886C>T	uc003phs.2	-	19	3962	c.3796G>A	c.(3796-3798)GTG>ATG	p.V1266M	COL12A1_uc003pht.2_Missense_Mutation_p.V102M	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1266	VWFA 3.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9																		---	---	---	---
HTR1B	3351	broad.mit.edu	37	6	78172719	78172719	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:78172719A>G	uc003pil.1	-	1	402	c.402T>C	c.(400-402)ACT>ACC	p.T134T		NM_000863	NP_000854	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B	134	Helical; Name=3; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity				0		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)													---	---	---	---
TTK	7272	broad.mit.edu	37	6	80720598	80720598	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:80720598G>A	uc003pjc.2	+	5	611	c.537G>A	c.(535-537)ATG>ATA	p.M179I	TTK_uc003pjb.3_Missense_Mutation_p.M179I	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	179					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)														---	---	---	---
PRSS35	167681	broad.mit.edu	37	6	84233649	84233649	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:84233649T>C	uc003pjz.2	+	2	652	c.489T>C	c.(487-489)CAT>CAC	p.H163H	PRSS35_uc010kbm.2_Silent_p.H163H	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	163	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)														---	---	---	---
CNR1	1268	broad.mit.edu	37	6	88853588	88853588	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:88853588G>A	uc011dzq.1	-	2	4969	c.1406C>T	c.(1405-1407)GCC>GTC	p.A469V	CNR1_uc010kbz.2_Missense_Mutation_p.A469V|CNR1_uc011dzr.1_Missense_Mutation_p.A469V|CNR1_uc011dzs.1_Missense_Mutation_p.A469V|CNR1_uc003pmq.3_Missense_Mutation_p.A469V|CNR1_uc011dzt.1_Missense_Mutation_p.A469V|CNR1_uc010kca.2_Missense_Mutation_p.A436V	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	469	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)													---	---	---	---
COQ3	51805	broad.mit.edu	37	6	99831610	99831610	+	Missense_Mutation	SNP	G	A	A	rs149717575	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:99831610G>A	uc003ppk.2	-	2	224	c.197C>T	c.(196-198)ACG>ATG	p.T66M		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	66					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)														---	---	---	---
PREP	5550	broad.mit.edu	37	6	105771530	105771530	+	Intron	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:105771530T>A	uc003prc.2	-							NM_002726	NP_002717			prolyl endopeptidase						proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)													---	---	---	---
WASF1	8936	broad.mit.edu	37	6	110428390	110428390	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:110428390C>A	uc003ptv.1	-	7	1267	c.430G>T	c.(430-432)GGT>TGT	p.G144C	WASF1_uc003ptw.1_Missense_Mutation_p.G144C|WASF1_uc003ptx.1_Missense_Mutation_p.G144C|WASF1_uc003pty.1_Missense_Mutation_p.G144C|WASF1_uc003ptz.1_Missense_Mutation_p.G144C	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	144					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)														---	---	---	---
WISP3	8838	broad.mit.edu	37	6	112382213	112382213	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112382213G>A	uc003pvm.2	+	3	178	c.68G>A	c.(67-69)GGC>GAC	p.G23D	WISP3_uc003pvn.2_RNA|WISP3_uc003pvo.2_Missense_Mutation_p.G41D	NM_003880	NP_003871	O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	23					cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding				0		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)														---	---	---	---
LAMA4	3910	broad.mit.edu	37	6	112452311	112452311	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:112452311G>A	uc003pvu.2	-						LAMA4_uc003pvv.2_Intron|LAMA4_uc003pvt.2_Intron	NM_001105206	NP_001098676			laminin, alpha 4 isoform 1 precursor						cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)														---	---	---	---
DSE	29940	broad.mit.edu	37	6	116757924	116757924	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:116757924C>T	uc003pws.2	+	6	2487	c.2293C>T	c.(2293-2295)CGG>TGG	p.R765W	DSE_uc011ebg.1_Missense_Mutation_p.R784W|DSE_uc003pwt.2_Missense_Mutation_p.R765W|DSE_uc003pwu.2_Missense_Mutation_p.R432W	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	765					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)														---	---	---	---
KPNA5	3841	broad.mit.edu	37	6	117026228	117026228	+	Intron	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:117026228T>C	uc003pxh.2	+							NM_002269	NP_002260			karyopherin alpha 5						NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)														---	---	---	---
THEMIS	387357	broad.mit.edu	37	6	128134599	128134599	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128134599G>A	uc003qbi.2	-	5	1506	c.1187C>T	c.(1186-1188)ACG>ATG	p.T396M	THEMIS_uc010kfa.2_Missense_Mutation_p.T299M|THEMIS_uc011ebt.1_Missense_Mutation_p.T396M|THEMIS_uc010kfb.2_Missense_Mutation_p.T361M	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	396	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4																		---	---	---	---
THEMIS	387357	broad.mit.edu	37	6	128150884	128150884	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:128150884A>G	uc003qbi.2	-	4	765	c.446T>C	c.(445-447)ATG>ACG	p.M149T	THEMIS_uc010kfa.2_Missense_Mutation_p.M52T|THEMIS_uc011ebt.1_Missense_Mutation_p.M149T|THEMIS_uc010kfb.2_Missense_Mutation_p.M114T	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	149	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4																		---	---	---	---
SAMD3	154075	broad.mit.edu	37	6	130476087	130476087	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:130476087C>A	uc003qbv.2	-	10	1232	c.906G>T	c.(904-906)TGG>TGT	p.W302C	SAMD3_uc003qbx.2_Missense_Mutation_p.W302C|SAMD3_uc003qbw.2_Missense_Mutation_p.W302C	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	302										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)														---	---	---	---
EPB41L2	2037	broad.mit.edu	37	6	131206333	131206333	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:131206333G>T	uc003qch.2	-	12	1918	c.1736C>A	c.(1735-1737)CCT>CAT	p.P579H	EPB41L2_uc003qce.1_5'Flank|EPB41L2_uc003qcf.1_5'Flank|EPB41L2_uc003qcg.1_Missense_Mutation_p.P579H|EPB41L2_uc011eby.1_Missense_Mutation_p.P579H|EPB41L2_uc003qci.2_Missense_Mutation_p.P579H|EPB41L2_uc010kfk.2_Missense_Mutation_p.P579H|EPB41L2_uc010kfl.1_Missense_Mutation_p.P579H	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	579	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)												OREG0017660	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
RPS12	6206	broad.mit.edu	37	6	133138636	133138636	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:133138636T>C	uc003qdx.2	+	6	436	c.354T>C	c.(352-354)TCT>TCC	p.S118S		NM_001016	NP_001007	P25398	RS12_HUMAN	ribosomal protein S12	118					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	structural constituent of ribosome				0	Breast(56;0.214)			OV - Ovarian serous cystadenocarcinoma(155;0.00284)|GBM - Glioblastoma multiforme(226;0.0256)														---	---	---	---
SLC2A12	154091	broad.mit.edu	37	6	134350554	134350554	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:134350554G>A	uc003qem.1	-	2	580	c.409C>T	c.(409-411)CGC>TGC	p.R137C		NM_145176	NP_660159	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose	137	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			ovary(1)	1	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)														---	---	---	---
AIG1	51390	broad.mit.edu	37	6	143382143	143382143	+	Silent	SNP	C	A	A	rs11556578		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:143382143C>A	uc003qjh.2	+	1	121	c.81C>A	c.(79-81)ATC>ATA	p.I27I	AIG1_uc003qjf.2_Silent_p.I17I|AIG1_uc003qji.2_Silent_p.I17I|AIG1_uc011edw.1_Silent_p.I27I|AIG1_uc003qjg.2_Silent_p.I27I	NM_016108	NP_057192	Q9NVV5	AIG1_HUMAN	androgen-induced 1	27						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(155;2.34e-05)|GBM - Glioblastoma multiforme(68;0.0246)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	144724272	144724272	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144724272C>T	uc003qkt.2	+	2	185	c.93C>T	c.(91-93)GAC>GAT	p.D31D	UTRN_uc010khq.1_Silent_p.D31D	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	31	CH 1.|Actin-binding.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	144801065	144801065	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144801065G>T	uc003qkt.2	+	25	3546	c.3454G>T	c.(3454-3456)GAT>TAT	p.D1152Y	UTRN_uc010khq.1_Missense_Mutation_p.D1152Y	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1152	Spectrin 8.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
UTRN	7402	broad.mit.edu	37	6	144811233	144811233	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:144811233T>C	uc003qkt.2	+	30	4253	c.4161T>C	c.(4159-4161)CAT>CAC	p.H1387H		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1387	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)														---	---	---	---
GRM1	2911	broad.mit.edu	37	6	146673400	146673400	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146673400G>A	uc010khw.1	+	5	1671	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K	GRM1_uc010khv.1_Missense_Mutation_p.E401K|GRM1_uc003qll.2_Missense_Mutation_p.E401K|GRM1_uc011edz.1_Missense_Mutation_p.E401K|GRM1_uc011eea.1_Missense_Mutation_p.E401K	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	401	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)													---	---	---	---
GRM1	2911	broad.mit.edu	37	6	146720020	146720020	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:146720020A>G	uc010khw.1	+	8	2315	c.1845A>G	c.(1843-1845)GTA>GTG	p.V615V	GRM1_uc010khv.1_Silent_p.V615V|GRM1_uc003qll.2_Silent_p.V615V|GRM1_uc011edz.1_Silent_p.V615V|GRM1_uc011eea.1_Silent_p.V615V	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	615	Helical; Name=1; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)													---	---	---	---
TAB2	23118	broad.mit.edu	37	6	149719193	149719193	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:149719193C>T	uc003qmj.2	+	5	2031	c.1853C>T	c.(1852-1854)GCC>GTC	p.A618V	TAB2_uc011eec.1_Missense_Mutation_p.A586V|TAB2_uc003qmk.3_RNA|SUMO4_uc003qml.2_5'Flank	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	618	Potential.				activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0																		---	---	---	---
LATS1	9113	broad.mit.edu	37	6	150023018	150023018	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:150023018C>T	uc003qmu.1	-	2	793	c.245G>A	c.(244-246)CGA>CAA	p.R82Q	LATS1_uc010kif.1_5'UTR|LATS1_uc003qmv.1_Missense_Mutation_p.R82Q|LATS1_uc003qmw.2_Missense_Mutation_p.R82Q|LATS1_uc010kig.1_5'UTR	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	82					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)														---	---	---	---
SYNE1	23345	broad.mit.edu	37	6	152772296	152772296	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:152772296A>G	uc010kiw.2	-	26	3674	c.3072T>C	c.(3070-3072)ATT>ATC	p.I1024I	SYNE1_uc003qot.3_Silent_p.I1031I|SYNE1_uc003qou.3_Silent_p.I1024I|SYNE1_uc010kjb.1_Silent_p.I1007I|SYNE1_uc003qow.2_Silent_p.I319I|SYNE1_uc003qox.1_Silent_p.I540I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1024	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)											HNSCC(10;0.0054)			---	---	---	---
TIAM2	26230	broad.mit.edu	37	6	155458397	155458397	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:155458397T>C	uc003qqb.2	+	7	2554	c.1281T>C	c.(1279-1281)TCT>TCC	p.S427S	TIAM2_uc003qqe.2_Silent_p.S427S|TIAM2_uc010kjj.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	427					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)														---	---	---	---
SYNJ2	8871	broad.mit.edu	37	6	158449919	158449919	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158449919C>T	uc003qqx.1	+	3	421	c.346C>T	c.(346-348)CGC>TGC	p.R116C	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Missense_Mutation_p.R116C|SYNJ2_uc003qqy.1_Translation_Start_Site|SYNJ2_uc011efn.1_Missense_Mutation_p.R65C|SYNJ2_uc010kjo.1_Missense_Mutation_p.R65C	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	116							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)														---	---	---	---
TULP4	56995	broad.mit.edu	37	6	158924493	158924493	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:158924493C>T	uc003qrf.2	+	13	5155	c.3798C>T	c.(3796-3798)TAC>TAT	p.Y1266Y	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1266					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160468904	160468904	+	Silent	SNP	C	T	T	rs145047577		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160468904C>T	uc003qta.2	+	17	2458	c.2310C>T	c.(2308-2310)ACC>ACT	p.T770T		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	770	5.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
IGF2R	3482	broad.mit.edu	37	6	160524772	160524772	+	Intron	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160524772T>A	uc003qta.2	+							NM_000876	NP_000867			insulin-like growth factor 2 receptor precursor						receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)														---	---	---	---
SLC22A1	6580	broad.mit.edu	37	6	160557309	160557309	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:160557309A>G	uc003qtc.2	+	5	1002	c.897A>G	c.(895-897)ATA>ATG	p.I299M	SLC22A1_uc003qtd.2_Missense_Mutation_p.I299M	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	299	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)														---	---	---	---
LPA	4018	broad.mit.edu	37	6	161032593	161032593	+	Splice_Site	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161032593C>T	uc003qtl.2	-	17	2723	c.2603_splice	c.e17+1	p.A868_splice		NM_005577	NP_005568			lipoprotein Lp(a) precursor						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)													---	---	---	---
PLG	5340	broad.mit.edu	37	6	161139414	161139414	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:161139414C>T	uc003qtm.3	+	8	939	c.876C>T	c.(874-876)TCC>TCT	p.S292S		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	292	Kringle 3.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)													---	---	---	---
PARK2	5071	broad.mit.edu	37	6	162394359	162394359	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:162394359T>C	uc003qtx.3	-	6	843	c.709A>G	c.(709-711)ACT>GCT	p.T237A	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_Missense_Mutation_p.T46A|PARK2_uc003qtw.3_Missense_Mutation_p.T46A|PARK2_uc003qty.3_Missense_Mutation_p.T209A|PARK2_uc003qtz.3_Missense_Mutation_p.T88A|PARK2_uc010kke.1_Missense_Mutation_p.T237A	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	237	SYT11 binding 1.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)														---	---	---	---
T	6862	broad.mit.edu	37	6	166580950	166580950	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr6:166580950C>T	uc003quu.1	-	2	623	c.130G>A	c.(130-132)GTG>ATG	p.V44M	T_uc003qut.1_Missense_Mutation_p.V44M|T_uc003quv.1_Missense_Mutation_p.V44M	NM_003181	NP_003172	O15178	BRAC_HUMAN	transcription factor T	44					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)										Chordoma_Familial_Clustering_of				---	---	---	---
HEATR2	54919	broad.mit.edu	37	7	796442	796442	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:796442C>T	uc010krz.1	+	6	1301	c.1281C>T	c.(1279-1281)GTC>GTT	p.V427V	HEATR2_uc003siz.2_Silent_p.V295V	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	427							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)														---	---	---	---
TMEM184A	202915	broad.mit.edu	37	7	1589976	1589976	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:1589976G>A	uc003skv.3	-	4	758	c.441C>T	c.(439-441)GGC>GGT	p.G147G	TMEM184A_uc003skt.3_5'UTR|TMEM184A_uc003skw.3_5'UTR	NM_001097620	NP_001091089	Q6ZMB5	T184A_HUMAN	transmembrane protein 184A	147	Helical; (Potential).					integral to membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;5.88e-15)														---	---	---	---
SDK1	221935	broad.mit.edu	37	7	4304818	4304818	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4304818C>T	uc003smx.2	+	45	6583	c.6444C>T	c.(6442-6444)AGC>AGT	p.S2148S	SDK1_uc010kso.2_Silent_p.S1404S|SDK1_uc003smy.2_Silent_p.S635S|SDK1_uc003smz.2_Silent_p.S208S	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2148	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)														---	---	---	---
RADIL	55698	broad.mit.edu	37	7	4917266	4917266	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:4917266C>T	uc003snj.1	-	2	678	c.505G>A	c.(505-507)GCA>ACA	p.A169T	RADIL_uc003sng.1_RNA|RADIL_uc011jwd.1_RNA	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	169					cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)														---	---	---	---
SLC29A4	222962	broad.mit.edu	37	7	5331406	5331406	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5331406C>T	uc003sod.2	+	5	659	c.498C>T	c.(496-498)TAC>TAT	p.Y166Y	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Silent_p.Y166Y|SLC29A4_uc003soe.2_Missense_Mutation_p.T154M	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	166	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)														---	---	---	---
ACTB	60	broad.mit.edu	37	7	5567376	5567376	+	3'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5567376C>T	uc003sos.3	-	5					ACTB_uc003sor.3_3'UTR|ACTB_uc003sot.3_3'UTR|ACTB_uc003soq.3_3'UTR|ACTB_uc010ksy.2_3'UTR	NM_001101	NP_001092			beta actin						'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)														---	---	---	---
FSCN1	6624	broad.mit.edu	37	7	5632920	5632920	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5632920G>A	uc003sou.2	+	1	467	c.353G>A	c.(352-354)CGC>CAC	p.R118H		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	118					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)														---	---	---	---
FSCN1	6624	broad.mit.edu	37	7	5633295	5633295	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:5633295G>A	uc003sou.2	+	1	842	c.728G>A	c.(727-729)GGC>GAC	p.G243D		NM_003088	NP_003079	Q16658	FSCN1_HUMAN	fascin 1	243					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			ovary(1)	1		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)														---	---	---	---
DAGLB	221955	broad.mit.edu	37	7	6449537	6449537	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:6449537G>A	uc003sqa.2	-	15	2120	c.1950C>T	c.(1948-1950)AGC>AGT	p.S650S	DAGLB_uc003spy.2_Silent_p.S196S|DAGLB_uc003spz.2_Silent_p.S347S|DAGLB_uc011jwt.1_Silent_p.S464S|DAGLB_uc011jwu.1_Silent_p.S521S|DAGLB_uc003sqb.2_Silent_p.S369S|DAGLB_uc003sqc.2_Silent_p.S369S|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Silent_p.S609S	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	650	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)														---	---	---	---
THSD7A	221981	broad.mit.edu	37	7	11441568	11441568	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:11441568G>T	uc003ssf.3	-	22	4517	c.4265C>A	c.(4264-4266)TCC>TAC	p.S1422Y		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1422	Extracellular (Potential).|TSP type-1 15.					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)											HNSCC(18;0.044)			---	---	---	---
TMEM106B	54664	broad.mit.edu	37	7	12263988	12263988	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:12263988C>T	uc011jxk.1	+	5	818	c.418C>T	c.(418-420)CGT>TGT	p.R140C	TMEM106B_uc003ssh.2_Missense_Mutation_p.R140C	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	140						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)														---	---	---	---
CCDC129	223075	broad.mit.edu	37	7	31617908	31617908	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:31617908G>A	uc003tcj.1	+	8	2023	c.1030G>A	c.(1030-1032)GCC>ACC	p.A344T	CCDC129_uc011kad.1_Missense_Mutation_p.A354T|CCDC129_uc003tci.1_Intron|CCDC129_uc011kae.1_Missense_Mutation_p.A370T|CCDC129_uc003tck.1_Missense_Mutation_p.A252T	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	344											0																		---	---	---	---
SPDYE1	285955	broad.mit.edu	37	7	44040788	44040788	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44040788T>G	uc003tjf.2	+	1	300	c.164T>G	c.(163-165)GTA>GGA	p.V55G	POLR2J4_uc003tjc.2_Intron|POLR2J4_uc003tjd.2_Intron|POLR2J4_uc010kxw.2_Intron|POLR2J4_uc003tje.3_Intron	NM_175064	NP_778234	Q8NFV5	SPDE1_HUMAN	Williams Beuren syndrome chromosome region 19	55										ovary(1)	1																		---	---	---	---
GCK	2645	broad.mit.edu	37	7	44189576	44189576	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44189576G>A	uc003tkl.2	-	5	1041	c.571C>T	c.(571-573)CGG>TGG	p.R191W	GCK_uc003tkj.1_Missense_Mutation_p.R190W|GCK_uc003tkk.1_Missense_Mutation_p.R192W	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	191					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4																		---	---	---	---
NPC1L1	29881	broad.mit.edu	37	7	44574135	44574135	+	Missense_Mutation	SNP	G	A	A	rs114737991	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44574135G>A	uc003tlb.2	-	6	2133	c.2077C>T	c.(2077-2079)CGC>TGC	p.R693C	NPC1L1_uc003tlc.2_Missense_Mutation_p.R693C|NPC1L1_uc011kbw.1_Missense_Mutation_p.R693C|NPC1L1_uc003tld.2_Missense_Mutation_p.R693C	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	693	SSD.|Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)											OREG0018038	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ZMIZ2	83637	broad.mit.edu	37	7	44800124	44800124	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:44800124A>G	uc003tlr.2	+	9	1295	c.1172A>G	c.(1171-1173)CAA>CGA	p.Q391R	ZMIZ2_uc003tlq.2_Missense_Mutation_p.Q333R|ZMIZ2_uc003tls.2_Missense_Mutation_p.Q365R|ZMIZ2_uc003tlt.2_Missense_Mutation_p.Q14R|ZMIZ2_uc010kyj.2_5'UTR	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	391	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5																		---	---	---	---
IKZF1	10320	broad.mit.edu	37	7	50450374	50450374	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50450374C>T	uc003tow.3	+	6	726	c.558C>T	c.(556-558)GAC>GAT	p.D186D	IKZF1_uc003tox.3_Silent_p.D186D|IKZF1_uc003toy.3_Silent_p.D186D|IKZF1_uc011kck.1_Silent_p.D99D|IKZF1_uc003toz.3_Silent_p.D156D|IKZF1_uc010kyx.2_Intron	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	186	C2H2-type 3.|Required for both high-affinity DNA binding and pericentromeric heterochromatin localization (By similarity).				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(74)		haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)						D		ALL								---	---	---	---
IKZF1	10320	broad.mit.edu	37	7	50468106	50468106	+	Silent	SNP	C	T	T	rs143013761	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50468106C>T	uc003tow.3	+	9	1509	c.1341C>T	c.(1339-1341)GAC>GAT	p.D447D	IKZF1_uc003tox.3_Silent_p.D405D|IKZF1_uc003toy.3_Silent_p.D405D|IKZF1_uc011kck.1_Silent_p.D360D|IKZF1_uc003toz.3_Silent_p.D417D|IKZF1_uc010kyx.2_Silent_p.D187D|IKZF1_uc003tpa.3_Silent_p.D189D	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	447					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)						D		ALL								---	---	---	---
GRB10	2887	broad.mit.edu	37	7	50799979	50799979	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:50799979G>A	uc003tpi.2	-	1	72	c.41C>T	c.(40-42)CCG>CTG	p.P14L	GRB10_uc003tpj.2_Missense_Mutation_p.P14L|GRB10_uc003tpk.2_Missense_Mutation_p.P14L|GRB10_uc010kzb.2_Intron|GRB10_uc003tpl.2_Intron|GRB10_uc003tpm.2_Intron|GRB10_uc003tpn.2_Intron	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	14					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)													Russell-Silver_syndrome				---	---	---	---
EGFR	1956	broad.mit.edu	37	7	55269026	55269026	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:55269026G>A	uc003tqk.2	+	25	3338	c.3092G>A	c.(3091-3093)CGG>CAG	p.R1031Q	EGFR_uc010kzg.1_Missense_Mutation_p.R986Q|EGFR_uc011kco.1_Missense_Mutation_p.R978Q	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	1031	Cytoplasmic (Potential).|Ser-rich.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			---	---	---	---
POM121C	100101267	broad.mit.edu	37	7	75048170	75048170	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:75048170G>A	uc003udk.3	-	15	3758	c.2873C>T	c.(2872-2874)GCG>GTG	p.A958V		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	1200	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0																		---	---	---	---
SEMA3E	9723	broad.mit.edu	37	7	83037703	83037703	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:83037703G>A	uc003uhy.1	-	6	1117	c.651C>T	c.(649-651)GAC>GAT	p.D217D		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	217	Sema.				axon guidance	extracellular space|membrane	receptor activity	p.D217D(1)		ovary(3)	3		Medulloblastoma(109;0.109)																---	---	---	---
RUNDC3B	154661	broad.mit.edu	37	7	87436695	87436695	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:87436695C>T	uc003ujb.2	+	10	1426	c.1015C>T	c.(1015-1017)CTA>TTA	p.L339L	RUNDC3B_uc011khd.1_Silent_p.L322L|RUNDC3B_uc011khe.1_Silent_p.L322L|RUNDC3B_uc003ujc.2_Intron|RUNDC3B_uc003ujd.2_Intron	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	339	Potential.									skin(1)	1	Esophageal squamous(14;0.00164)																	---	---	---	---
AKAP9	10142	broad.mit.edu	37	7	91715653	91715653	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:91715653C>T	uc003ulg.2	+	37	9361	c.9136C>T	c.(9136-9138)CGG>TGG	p.R3046W	AKAP9_uc003ulf.2_Missense_Mutation_p.R3038W|AKAP9_uc003uli.2_Missense_Mutation_p.R2669W|AKAP9_uc003ulj.2_Missense_Mutation_p.R816W|AKAP9_uc003ulk.2_Missense_Mutation_p.R321W	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3050					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)					T	BRAF	papillary thyroid								---	---	---	---
LMTK2	22853	broad.mit.edu	37	7	97821334	97821334	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:97821334C>T	uc003upd.1	+	11	1850	c.1557C>T	c.(1555-1557)CCC>CCT	p.P519P		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	519					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)																	---	---	---	---
TRRAP	8295	broad.mit.edu	37	7	98557049	98557049	+	Missense_Mutation	SNP	G	A	A	rs149626121	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98557049G>A	uc003upp.2	+	44	6613	c.6404G>A	c.(6403-6405)CGG>CAG	p.R2135Q	TRRAP_uc011kis.1_Missense_Mutation_p.R2117Q|TRRAP_uc003upr.2_Missense_Mutation_p.R1834Q	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2135	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
ARPC1B	10095	broad.mit.edu	37	7	98988840	98988840	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:98988840G>A	uc003upz.2	+	7	836	c.747G>A	c.(745-747)GCG>GCA	p.A249A	ARPC1B_uc003uqa.2_Silent_p.A249A|ARPC1B_uc003uqb.2_Silent_p.A249A|ARPC1B_uc003uqc.2_Silent_p.A249A|ARPC1B_uc003uqd.2_Silent_p.A61A	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	249	WD 5.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)															---	---	---	---
SPDYE3	441272	broad.mit.edu	37	7	99913460	99913460	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:99913460A>G	uc003uug.1	+	2	363	c.123A>G	c.(121-123)TCA>TCG	p.S41S		NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	418											0																		---	---	---	---
C7orf51	222950	broad.mit.edu	37	7	100086958	100086958	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100086958G>A	uc003uvd.1	+	4	1773	c.1614G>A	c.(1612-1614)CCG>CCA	p.P538P	C7orf51_uc003uve.1_Silent_p.P320P	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	538										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)																	---	---	---	---
GIGYF1	64599	broad.mit.edu	37	7	100284988	100284988	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100284988C>T	uc003uwg.1	-	5	1424	c.415G>A	c.(415-417)GAA>AAA	p.E139K		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	139										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)																	---	---	---	---
EPHB4	2050	broad.mit.edu	37	7	100417393	100417393	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100417393G>A	uc003uwn.1	-	6	1574	c.1083C>T	c.(1081-1083)TGC>TGT	p.C361C	EPHB4_uc003uwm.1_Silent_p.C268C|EPHB4_uc010lhj.1_Silent_p.C361C|EPHB4_uc011kkf.1_Silent_p.C361C|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Silent_p.C361C	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	361	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
SLC12A9	56996	broad.mit.edu	37	7	100463810	100463810	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100463810G>T	uc003uwp.2	+	14	2470	c.2328G>T	c.(2326-2328)GAG>GAT	p.E776D	SLC12A9_uc011kki.1_Missense_Mutation_p.E307D|SLC12A9_uc003uwr.2_Missense_Mutation_p.E512D|SLC12A9_uc003uws.2_Missense_Mutation_p.E307D|SLC12A9_uc003uwt.2_Missense_Mutation_p.E512D|SLC12A9_uc003uwv.2_Missense_Mutation_p.E307D|TRIP6_uc010lhk.1_5'Flank|TRIP6_uc003uww.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	776	Cytoplasmic (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)																	---	---	---	---
ACHE	43	broad.mit.edu	37	7	100491548	100491548	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100491548T>C	uc003uxd.2	-	1	462	c.306A>G	c.(304-306)CAA>CAG	p.Q102Q	ACHE_uc003uxe.2_Silent_p.Q102Q|ACHE_uc003uxf.2_Silent_p.Q102Q|ACHE_uc003uxg.2_Silent_p.Q102Q|ACHE_uc003uxh.2_Silent_p.Q102Q|ACHE_uc003uxi.2_Silent_p.Q102Q|ACHE_uc003uxj.1_Silent_p.Q221Q	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	102					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)													---	---	---	---
C7orf52	375607	broad.mit.edu	37	7	100817842	100817842	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:100817842G>A	uc003uxy.1	-	2	486	c.247C>T	c.(247-249)CGC>TGC	p.R83C	C7orf52_uc003uxz.1_Missense_Mutation_p.R83C|C7orf52_uc003uya.1_Missense_Mutation_p.R83C|C7orf52_uc003uyb.1_Missense_Mutation_p.R83C	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	83	N-acetyltransferase.						N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)																	---	---	---	---
SH2B2	10603	broad.mit.edu	37	7	101952177	101952177	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:101952177C>T	uc011kko.1	+	4	1086	c.1041C>T	c.(1039-1041)TGC>TGT	p.C347C		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	304	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0																		---	---	---	---
RELN	5649	broad.mit.edu	37	7	103113350	103113350	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:103113350C>T	uc003vca.2	-	66	10452	c.10292G>A	c.(10291-10293)CGC>CAC	p.R3431H	RELN_uc010liz.2_Missense_Mutation_p.R3429H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3431	Arg-rich (basic).				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)														---	---	---	---
RINT1	60561	broad.mit.edu	37	7	105195574	105195574	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:105195574T>C	uc003vda.1	+	11	1802	c.1571T>C	c.(1570-1572)ATG>ACG	p.M524T	RINT1_uc010ljj.1_Missense_Mutation_p.M99T	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	524	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4																		---	---	---	---
LAMB4	22798	broad.mit.edu	37	7	107708575	107708575	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:107708575C>A	uc010ljo.1	-	19	2416	c.2332G>T	c.(2332-2334)GGA>TGA	p.G778*	LAMB4_uc003vey.2_Nonsense_Mutation_p.G778*	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	778	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8																		---	---	---	---
IFRD1	3475	broad.mit.edu	37	7	112098933	112098933	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:112098933C>T	uc003vgh.2	+	6	870	c.427C>T	c.(427-429)CGT>TGT	p.R143C	IFRD1_uc011kmn.1_Missense_Mutation_p.R93C|IFRD1_uc003vgj.2_Missense_Mutation_p.R143C|IFRD1_uc011kmo.1_Intron|IFRD1_uc011kmp.1_Missense_Mutation_p.R93C	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	143					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2																		---	---	---	---
PPP1R3A	5506	broad.mit.edu	37	7	113518220	113518220	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:113518220A>G	uc010ljy.1	-	4	2958	c.2927T>C	c.(2926-2928)GTT>GCT	p.V976A		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	976					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34																		---	---	---	---
MET	4233	broad.mit.edu	37	7	116339279	116339279	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:116339279C>T	uc003vij.2	+	2	328	c.141C>T	c.(139-141)ACC>ACT	p.T47T	MET_uc010lkh.2_Silent_p.T47T|MET_uc011knc.1_Silent_p.T47T|MET_uc011knd.1_Silent_p.T47T|MET_uc011kne.1_Silent_p.T47T|MET_uc011knf.1_Silent_p.T47T|MET_uc011kng.1_Silent_p.T47T|MET_uc011knh.1_Silent_p.T47T|MET_uc011kni.1_Silent_p.T47T|MET_uc003vii.1_Silent_p.T66T|MET_uc010lkg.2_Silent_p.T47T|MET_uc011kmz.1_Silent_p.T47T|MET_uc011kna.1_Silent_p.T47T|MET_uc011knb.1_Silent_p.T47T	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	47	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.982_1028del47(8)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)					Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				---	---	---	---
CFTR	1080	broad.mit.edu	37	7	117251692	117251692	+	Missense_Mutation	SNP	G	A	A	rs121909019		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:117251692G>A	uc003vjd.2	+	20	3329	c.3197G>A	c.(3196-3198)CGT>CAT	p.R1066H	CFTR_uc011knq.1_Missense_Mutation_p.R472H	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1066	Cytoplasmic (Potential).|ABC transmembrane type-1 2.		R -> H (in CF).|R -> L (in CF).|R -> C (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)									Cystic_Fibrosis				---	---	---	---
FSCN3	29999	broad.mit.edu	37	7	127235581	127235581	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:127235581A>G	uc003vmd.1	+	2	584	c.365A>G	c.(364-366)GAC>GGC	p.D122G	FSCN3_uc003vmc.1_Missense_Mutation_p.D77G|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_5'UTR|FSCN3_uc010llc.1_Missense_Mutation_p.D122G	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	122						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1																		---	---	---	---
FAM71F1	84691	broad.mit.edu	37	7	128355644	128355644	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:128355644C>T	uc003vno.1	+	1	202	c.149C>T	c.(148-150)GCG>GTG	p.A50V	FAM71F1_uc010llo.1_Intron|FAM71F1_uc011koq.1_Intron|FAM71F1_uc003vnm.1_Intron|FAM71F1_uc003vnn.1_Intron|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.A50V	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	50										skin(1)	1																		---	---	---	---
CPA5	93979	broad.mit.edu	37	7	130007829	130007829	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:130007829T>G	uc010lmd.1	+	13	1741	c.1121T>G	c.(1120-1122)CTC>CGC	p.L374R	CPA5_uc003vps.2_Missense_Mutation_p.L374R|CPA5_uc003vpt.2_Intron|CPA5_uc010lme.1_Missense_Mutation_p.L374R|CPA5_uc003vpu.1_Missense_Mutation_p.L374R|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	374					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)																	---	---	---	---
PL-5283	647087	broad.mit.edu	37	7	135344793	135344793	+	5'Flank	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:135344793G>A	uc003vsy.2	+						PL-5283_uc003vsz.3_5'Flank	NM_001130929	NP_001124401			PL-5283 protein												0																		---	---	---	---
SVOPL	136306	broad.mit.edu	37	7	138333785	138333785	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:138333785G>A	uc011kqh.1	-	7	632	c.632C>T	c.(631-633)CCG>CTG	p.P211L	SVOPL_uc003vue.2_Missense_Mutation_p.P59L	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	211	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0																		---	---	---	---
TAS2R38	5726	broad.mit.edu	37	7	141673015	141673015	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:141673015C>T	uc003vwx.1	-	1	559	c.475G>A	c.(475-477)GTT>ATT	p.V159I		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	159	Helical; Name=4; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)																	---	---	---	---
Unknown	0	broad.mit.edu	37	7	142045544	142045544	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:142045544G>A	uc011kro.1	+						uc011krp.1_Intron|uc011krr.1_Intron|uc003vxp.3_Silent_p.T24T|uc011krt.1_Silent_p.T6T					SubName: Full=V_segment translation product; Flags: Fragment;																														---	---	---	---
TAS2R60	338398	broad.mit.edu	37	7	143141232	143141232	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143141232T>C	uc011ktg.1	+	1	687	c.687T>C	c.(685-687)CTT>CTC	p.L229L	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	229	Cytoplasmic (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)																	---	---	---	---
OR2A25	392138	broad.mit.edu	37	7	143771428	143771428	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143771428T>C	uc011ktx.1	+	1	116	c.116T>C	c.(115-117)TTG>TCG	p.L39S		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)																	---	---	---	---
OR2A2	442361	broad.mit.edu	37	7	143807297	143807297	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:143807297G>A	uc011ktz.1	+	1	622	c.622G>A	c.(622-624)GGG>AGG	p.G208R		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)																	---	---	---	---
CNTNAP2	26047	broad.mit.edu	37	7	146536847	146536847	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:146536847C>T	uc003weu.1	+	3	769	c.253C>T	c.(253-255)CTT>TTT	p.L85F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	85	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)												HNSCC(39;0.1)			---	---	---	---
ZNF786	136051	broad.mit.edu	37	7	148768876	148768876	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:148768876G>A	uc003wfh.2	-	4	1125	c.988C>T	c.(988-990)CGC>TGC	p.R330C	ZNF786_uc011kuk.1_Missense_Mutation_p.R293C|ZNF786_uc003wfi.2_Missense_Mutation_p.R244C	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)															---	---	---	---
SSPO	23145	broad.mit.edu	37	7	149500639	149500639	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149500639C>T	uc010lpk.2	+	55	8040	c.8040C>T	c.(8038-8040)GGC>GGT	p.G2680G		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2680					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)															---	---	---	---
ZNF862	643641	broad.mit.edu	37	7	149543278	149543278	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:149543278G>A	uc010lpn.2	+	3	367	c.175G>A	c.(175-177)GGA>AGA	p.G59R	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	59	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1																		---	---	---	---
ABCB8	11194	broad.mit.edu	37	7	150739068	150739068	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:150739068G>A	uc003wil.3	+	15	1782	c.1689G>A	c.(1687-1689)ACG>ACA	p.T563T	ABCB8_uc010lpw.1_3'UTR|ABCB8_uc010lpx.2_Silent_p.T546T|ABCB8_uc011kvd.1_Silent_p.T458T|ABCB8_uc003wim.3_Silent_p.T341T|ABCB8_uc003wik.3_Silent_p.T546T	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	563	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)														---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151841898	151841898	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151841898G>A	uc003wla.2	-	55	14462	c.14243C>T	c.(14242-14244)GCA>GTA	p.A4748V	MLL3_uc003wkz.2_Missense_Mutation_p.A3862V|MLL3_uc003wkx.2_Missense_Mutation_p.A906V|MLL3_uc003wky.2_Missense_Mutation_p.A2308V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4748					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151877105	151877105	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151877105G>T	uc003wla.2	-	37	7475	c.7256C>A	c.(7255-7257)CCT>CAT	p.P2419H	MLL3_uc003wkz.2_Missense_Mutation_p.P1480H|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2419	Pro-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151891162	151891162	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151891162G>A	uc003wla.2	-	31	4811	c.4592C>T	c.(4591-4593)GCG>GTG	p.A1531V	MLL3_uc003wkz.2_Missense_Mutation_p.A592V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1531					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
MLL3	58508	broad.mit.edu	37	7	151935847	151935847	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:151935847C>T	uc003wla.2	-	15	2816	c.2597G>A	c.(2596-2598)CGG>CAG	p.R866Q	MLL3_uc003wkz.2_5'UTR	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	866					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)				N		medulloblastoma								---	---	---	---
NOM1	64434	broad.mit.edu	37	7	156752777	156752777	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr7:156752777G>T	uc003wmy.2	+	4	1556	c.1541G>T	c.(1540-1542)AGG>ATG	p.R514M	NOM1_uc010lqp.1_5'Flank	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	514	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)														---	---	---	---
ANGPT2	285	broad.mit.edu	37	8	6389908	6389908	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:6389908T>A	uc003wqj.3	-	2	718	c.389A>T	c.(388-390)AAC>ATC	p.N130I	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.N130I|ANGPT2_uc010lri.2_Intron|ANGPT2_uc003wql.3_Missense_Mutation_p.N130I	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	130					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)														---	---	---	---
XKR6	286046	broad.mit.edu	37	8	10755924	10755924	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:10755924G>A	uc003wtk.1	-	3	1491	c.1464C>T	c.(1462-1464)ATC>ATT	p.I488I		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	488	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)														---	---	---	---
BMP1	649	broad.mit.edu	37	8	22064891	22064891	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:22064891G>A	uc003xbg.2	+	18	2681	c.2437G>A	c.(2437-2439)GCC>ACC	p.A813T	BMP1_uc011kzc.1_Missense_Mutation_p.A562T|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	813	CUB 4.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)														---	---	---	---
TNFRSF10D	8793	broad.mit.edu	37	8	23021352	23021352	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23021352G>T	uc003xcz.1	-	1	189	c.97C>A	c.(97-99)CTG>ATG	p.L33M		NM_003840	NP_003831	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily,	33					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)												OREG0018632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
LOXL2	4017	broad.mit.edu	37	8	23159604	23159604	+	Missense_Mutation	SNP	C	T	T	rs141432206	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:23159604C>T	uc003xdh.1	-	12	2408	c.2069G>A	c.(2068-2070)CGC>CAC	p.R690H	LOXL2_uc010lty.1_Missense_Mutation_p.R229H	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	690	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25224467	25224467	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25224467C>T	uc003xeg.2	+	31	3342	c.3205C>T	c.(3205-3207)CGC>TGC	p.R1069C	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.R783C|DOCK5_uc003xei.2_Missense_Mutation_p.R639C|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1069						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
DOCK5	80005	broad.mit.edu	37	8	25226177	25226177	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:25226177T>C	uc003xeg.2	+	33	3511	c.3374T>C	c.(3373-3375)ATC>ACC	p.I1125T	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.I839T|DOCK5_uc003xei.2_Missense_Mutation_p.I695T|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1125						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)														---	---	---	---
TRIM35	23087	broad.mit.edu	37	8	27145238	27145238	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:27145238G>A	uc003xfl.1	-	6	1393	c.1311C>T	c.(1309-1311)GGC>GGT	p.G437G	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	437	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)														---	---	---	---
WRN	7486	broad.mit.edu	37	8	30924662	30924662	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:30924662T>C	uc003xio.3	+	6	1406	c.618T>C	c.(616-618)ACT>ACC	p.T206T		NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	206	Interaction with WRNIP1 (By similarity).|3'-5' exonuclease.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)				Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				---	---	---	---
GPR124	25960	broad.mit.edu	37	8	37688243	37688243	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:37688243T>C	uc003xkj.2	+	7	1097	c.734T>C	c.(733-735)CTG>CCG	p.L245P	GPR124_uc010lvy.2_Missense_Mutation_p.L245P	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	245	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)															---	---	---	---
FGFR1	2260	broad.mit.edu	37	8	38282215	38282215	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:38282215G>A	uc003xlp.2	-	7	1690	c.748C>T	c.(748-750)CGG>TGG	p.R250W	FGFR1_uc011lbo.1_Missense_Mutation_p.R248W|FGFR1_uc011lbp.1_Missense_Mutation_p.R161W|FGFR1_uc011lbq.1_Missense_Mutation_p.R159W|FGFR1_uc010lwk.2_Missense_Mutation_p.R242W|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_Missense_Mutation_p.R90W|FGFR1_uc011lbt.1_Missense_Mutation_p.R159W|FGFR1_uc011lbu.1_Missense_Mutation_p.R281W|FGFR1_uc011lbv.1_Missense_Mutation_p.R248W|FGFR1_uc011lbw.1_Missense_Mutation_p.R161W|FGFR1_uc011lbx.1_Missense_Mutation_p.R161W|FGFR1_uc003xlv.2_Missense_Mutation_p.R161W|FGFR1_uc003xlu.2_Missense_Mutation_p.R159W	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	250	Extracellular (Potential).		R -> W (in KAL2).		axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						---	---	---	---
FNTA	2339	broad.mit.edu	37	8	42939925	42939925	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:42939925T>C	uc003xps.2	+	8	966	c.918T>C	c.(916-918)CAT>CAC	p.H306H	FNTA_uc003xpt.2_Silent_p.H215H|FNTA_uc003xpu.2_Silent_p.H239H|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	306					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)															---	---	---	---
PRKDC	5591	broad.mit.edu	37	8	48744483	48744483	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:48744483C>T	uc003xqi.2	-	61	8214	c.8157G>A	c.(8155-8157)GCG>GCA	p.A2719A	PRKDC_uc003xqj.2_Silent_p.A2719A|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2719	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)											NHEJ					---	---	---	---
ST18	9705	broad.mit.edu	37	8	53049172	53049172	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53049172C>T	uc003xqz.2	-	14	2434	c.2278G>A	c.(2278-2280)GCT>ACT	p.A760T	ST18_uc011ldq.1_Missense_Mutation_p.A407T|ST18_uc011ldr.1_Missense_Mutation_p.A725T|ST18_uc011lds.1_Missense_Mutation_p.A665T|ST18_uc003xra.2_Missense_Mutation_p.A760T	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	760						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)																---	---	---	---
NPBWR1	2831	broad.mit.edu	37	8	53852868	53852868	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:53852868G>A	uc011ldu.1	+	1	401	c.401G>A	c.(400-402)CGC>CAC	p.R134H		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	134	Cytoplasmic (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)																---	---	---	---
RGS20	8601	broad.mit.edu	37	8	54791841	54791841	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:54791841A>G	uc003xrp.2	+	2	281	c.189A>G	c.(187-189)CCA>CCG	p.P63P	RGS20_uc003xrq.2_Intron|RGS20_uc010lye.2_Intron|RGS20_uc010lyf.2_Intron|RGS20_uc003xrr.2_5'Flank|RGS20_uc003xrs.2_5'Flank|RGS20_uc003xrt.2_5'Flank	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	63					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)															---	---	---	---
YTHDF3	253943	broad.mit.edu	37	8	64100299	64100299	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:64100299G>A	uc003xuy.2	+	5	2046	c.1730G>A	c.(1729-1731)CGT>CAT	p.R577H	YTHDF3_uc010lys.2_Missense_Mutation_p.R521H|YTHDF3_uc003xuz.2_Missense_Mutation_p.R521H|YTHDF3_uc003xva.2_Missense_Mutation_p.R521H|YTHDF3_uc011len.1_Missense_Mutation_p.R521H	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	577											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
CSPP1	79848	broad.mit.edu	37	8	68102923	68102923	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68102923G>A	uc003xxi.2	+	29	3380	c.3349G>A	c.(3349-3351)GTC>ATC	p.V1117I	ARFGEF1_uc003xxl.1_Intron|CSPP1_uc003xxj.2_Missense_Mutation_p.V1082I|CSPP1_uc003xxk.2_Missense_Mutation_p.V737I|CSPP1_uc010lyw.2_Missense_Mutation_p.V177I	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1117						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)															---	---	---	---
ARFGEF1	10565	broad.mit.edu	37	8	68138270	68138270	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:68138270A>G	uc003xxo.1	-	28	4455	c.4065T>C	c.(4063-4065)TCT>TCC	p.S1355S	ARFGEF1_uc003xxl.1_Silent_p.S809S|ARFGEF1_uc003xxn.1_Silent_p.S338S	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1355					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)															---	---	---	---
PI15	51050	broad.mit.edu	37	8	75737491	75737491	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75737491G>A	uc003yal.2	+	2	186	c.7G>A	c.(7-9)GCA>ACA	p.A3T	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.A3T	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	3						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)															---	---	---	---
CRISPLD1	83690	broad.mit.edu	37	8	75937828	75937828	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:75937828G>A	uc003yan.2	+	13	1667	c.1292G>A	c.(1291-1293)CGT>CAT	p.R431H	CRISPLD1_uc011lfk.1_Missense_Mutation_p.R243H|CRISPLD1_uc011lfl.1_Missense_Mutation_p.R243H	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	431	LCCL 2.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)															---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77616881	77616881	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77616881G>A	uc003yav.2	+	2	945	c.558G>A	c.(556-558)TCG>TCA	p.S186S	ZFHX4_uc003yat.1_Silent_p.S186S|ZFHX4_uc003yau.1_Silent_p.S186S|ZFHX4_uc003yaw.1_Silent_p.S186S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	186						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77618388	77618388	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77618388G>A	uc003yav.2	+	2	2452	c.2065G>A	c.(2065-2067)GGT>AGT	p.G689S	ZFHX4_uc003yat.1_Missense_Mutation_p.G689S|ZFHX4_uc003yau.1_Missense_Mutation_p.G689S|ZFHX4_uc003yaw.1_Missense_Mutation_p.G689S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	689						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZFHX4	79776	broad.mit.edu	37	8	77763452	77763452	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:77763452G>A	uc003yav.2	+	10	4547	c.4160G>A	c.(4159-4161)CGC>CAC	p.R1387H	ZFHX4_uc003yau.1_Missense_Mutation_p.R1432H|ZFHX4_uc003yaw.1_Missense_Mutation_p.R1387H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1387	C2H2-type 11.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)												HNSCC(33;0.089)			---	---	---	---
ZNF704	619279	broad.mit.edu	37	8	81577212	81577212	+	Silent	SNP	C	T	T	rs141074182		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:81577212C>T	uc003yby.1	-	6	997	c.765G>A	c.(763-765)CCG>CCA	p.P255P		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	255						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)															---	---	---	---
DCAF4L2	138009	broad.mit.edu	37	8	88885905	88885905	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:88885905A>G	uc003ydz.2	-	1	392	c.295T>C	c.(295-297)TAC>CAC	p.Y99H		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	99										ovary(1)	1																		---	---	---	---
CDH17	1015	broad.mit.edu	37	8	95188798	95188798	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95188798T>C	uc003ygh.2	-	5	520	c.395A>G	c.(394-396)GAA>GGA	p.E132G	CDH17_uc011lgo.1_Missense_Mutation_p.E132G|CDH17_uc011lgp.1_Missense_Mutation_p.E132G	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	132	Extracellular (Potential).|Cadherin 2.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
GEM	2669	broad.mit.edu	37	8	95272569	95272569	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95272569G>A	uc003ygj.2	-	2	412	c.163C>T	c.(163-165)CGC>TGC	p.R55C	GEM_uc003ygi.2_Missense_Mutation_p.R55C	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	55					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)															---	---	---	---
RAD54B	25788	broad.mit.edu	37	8	95416312	95416312	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95416312C>A	uc003ygk.2	-	6	1035	c.937G>T	c.(937-939)GGA>TGA	p.G313*	RAD54B_uc010may.1_Nonsense_Mutation_p.G120*|RAD54B_uc003ygl.1_RNA	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)										Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
KIAA1429	25962	broad.mit.edu	37	8	95556069	95556069	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:95556069G>A	uc003ygo.1	-	2	178	c.165C>T	c.(163-165)GAC>GAT	p.D55D	KIAA1429_uc003ygp.2_Silent_p.D55D	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	55					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)															---	---	---	---
PLEKHF2	79666	broad.mit.edu	37	8	96166569	96166569	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:96166569A>G	uc003yhn.1	+	2	544	c.297A>G	c.(295-297)GGA>GGG	p.G99G		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	99	PH.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)																	---	---	---	---
POP1	10940	broad.mit.edu	37	8	99152382	99152382	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99152382A>G	uc003yij.3	+	10	1539	c.1439A>G	c.(1438-1440)CAT>CGT	p.H480R	POP1_uc011lgv.1_Missense_Mutation_p.H480R|POP1_uc003yik.2_Missense_Mutation_p.H480R	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	480					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)															---	---	---	---
STK3	6788	broad.mit.edu	37	8	99468194	99468194	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:99468194C>T	uc003yip.2	-	11	1493	c.1352G>A	c.(1351-1353)CGG>CAG	p.R451Q	STK3_uc003yio.2_Missense_Mutation_p.R479Q	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	451	SARAH.|Potential.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)														---	---	---	---
CTHRC1	115908	broad.mit.edu	37	8	104388039	104388039	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:104388039C>T	uc003ylk.2	+	2	323	c.224C>T	c.(223-225)CCG>CTG	p.P75L	CTHRC1_uc011lhq.1_Missense_Mutation_p.P75L	NM_138455	NP_612464	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	75	Collagen-like.					collagen				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)															---	---	---	---
TTC35	9694	broad.mit.edu	37	8	109489111	109489111	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:109489111G>C	uc003ymw.1	+	9	727	c.692G>C	c.(691-693)GGA>GCA	p.G231A		NM_014673	NP_055488	Q15006	TTC35_HUMAN	tetratricopeptide repeat domain 35	231						endoplasmic reticulum|nucleus	binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.34e-10)															---	---	---	---
TMEM74	157753	broad.mit.edu	37	8	109796626	109796626	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:109796626C>T	uc003ymy.1	-	2	807	c.702G>A	c.(700-702)GCG>GCA	p.A234A	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	234	Helical; (Potential).				autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)															---	---	---	---
TRHR	7201	broad.mit.edu	37	8	110099973	110099973	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110099973G>A	uc003ymz.3	+	1	248	c.232G>A	c.(232-234)GCA>ACA	p.A78T		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	78	Helical; Name=2; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)															---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110441683	110441683	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110441683C>T	uc003yne.2	+	26	3219	c.3115C>T	c.(3115-3117)CAG>TAG	p.Q1039*		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1039	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
PKHD1L1	93035	broad.mit.edu	37	8	110478930	110478930	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:110478930G>A	uc003yne.2	+	50	8641	c.8537G>A	c.(8536-8538)CGT>CAT	p.R2846H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2846	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)												HNSCC(38;0.096)			---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116599370	116599370	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116599370C>T	uc003ynz.2	-	4	2978	c.2519G>A	c.(2518-2520)CGA>CAA	p.R840Q	TRPS1_uc011lhy.1_Missense_Mutation_p.R844Q|TRPS1_uc003yny.2_Missense_Mutation_p.R853Q|TRPS1_uc010mcy.2_Missense_Mutation_p.R840Q	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	840					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
TRPS1	7227	broad.mit.edu	37	8	116599476	116599476	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:116599476A>G	uc003ynz.2	-	4	2872	c.2413T>C	c.(2413-2415)TCA>CCA	p.S805P	TRPS1_uc011lhy.1_Missense_Mutation_p.S809P|TRPS1_uc003yny.2_Missense_Mutation_p.S818P|TRPS1_uc010mcy.2_Missense_Mutation_p.S805P	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	805	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)											Langer-Giedion_syndrome				---	---	---	---
SLC30A8	169026	broad.mit.edu	37	8	118165289	118165289	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:118165289G>A	uc003yoh.2	+	3	608	c.378G>A	c.(376-378)AAG>AAA	p.K126K	SLC30A8_uc010mcz.2_Silent_p.K77K|SLC30A8_uc011lia.1_Silent_p.K77K|SLC30A8_uc003yog.2_Silent_p.K77K	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	126	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)															---	---	---	---
TG	7038	broad.mit.edu	37	8	133883773	133883773	+	Missense_Mutation	SNP	G	A	A	rs114781869	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:133883773G>A	uc003ytw.2	+	4	496	c.455G>A	c.(454-456)CGC>CAC	p.R152H		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	152	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)														---	---	---	---
WISP1	8840	broad.mit.edu	37	8	134232918	134232918	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:134232918C>T	uc003yub.2	+	3	520	c.444C>T	c.(442-444)GAC>GAT	p.D148D	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	148	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)															---	---	---	---
ZFAT	57623	broad.mit.edu	37	8	135622763	135622763	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:135622763G>A	uc003yup.2	-	4	759	c.584C>T	c.(583-585)GCG>GTG	p.A195V	ZFAT_uc003yun.2_Missense_Mutation_p.A183V|ZFAT_uc003yuo.2_Missense_Mutation_p.A183V|ZFAT_uc010meh.2_Missense_Mutation_p.A183V|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.A183V|ZFAT_uc010mej.2_Intron|ZFAT_uc003yur.2_Missense_Mutation_p.A183V	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)															---	---	---	---
COL22A1	169044	broad.mit.edu	37	8	139601521	139601521	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:139601521C>T	uc003yvd.2	-	65	5303	c.4856G>A	c.(4855-4857)CGG>CAG	p.R1619Q	COL22A1_uc011ljo.1_Missense_Mutation_p.R899Q	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1619					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)												HNSCC(7;0.00092)			---	---	---	---
SLC45A4	57210	broad.mit.edu	37	8	142228560	142228560	+	Silent	SNP	G	A	A	rs12679511		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142228560G>A	uc003ywd.1	-	4	1334	c.1026C>T	c.(1024-1026)GAC>GAT	p.D342D	SLC45A4_uc003ywc.1_Silent_p.D342D|SLC45A4_uc010meq.1_Silent_p.D340D	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	393					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
FLJ43860	389690	broad.mit.edu	37	8	142446864	142446864	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:142446864C>T	uc003ywi.2	-	27	3402	c.3321G>A	c.(3319-3321)ACG>ACA	p.T1107T	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_Intron	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1107							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)															---	---	---	---
JRK	8629	broad.mit.edu	37	8	143746320	143746320	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143746320C>T	uc003ywo.2	-	2	1672	c.1158G>A	c.(1156-1158)TGG>TGA	p.W386*	JRK_uc003ywp.2_Nonsense_Mutation_p.W386*|JRK_uc010mew.1_Nonsense_Mutation_p.W386*	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)																---	---	---	---
JRK	8629	broad.mit.edu	37	8	143747244	143747244	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:143747244C>T	uc003ywo.2	-	2	748	c.234G>A	c.(232-234)CGG>CGA	p.R78R	JRK_uc003ywp.2_Silent_p.R78R|JRK_uc010mew.1_Silent_p.R78R	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)																---	---	---	---
C8orf31	286122	broad.mit.edu	37	8	144124626	144124626	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144124626G>A	uc003yxp.1	+	3	485	c.133G>A	c.(133-135)GCA>ACA	p.A45T	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_RNA	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	45										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)																	---	---	---	---
C8orf73	642475	broad.mit.edu	37	8	144652731	144652731	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144652731G>C	uc010mff.2	-	5	861	c.817C>G	c.(817-819)CTG>GTG	p.L273V	C8orf73_uc010mfg.1_Missense_Mutation_p.L273V	NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	273							binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
MAPK15	225689	broad.mit.edu	37	8	144804425	144804425	+	3'UTR	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144804425G>A	uc003yzj.2	+	14						NM_139021	NP_620590			mitogen-activated protein kinase 15						protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			lung(2)	2	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)															---	---	---	---
SCRIB	23513	broad.mit.edu	37	8	144893468	144893468	+	Silent	SNP	G	A	A	rs145794409		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144893468G>A	uc003yzp.1	-	10	961	c.954C>T	c.(952-954)AAC>AAT	p.N318N	SCRIB_uc003yzo.1_Silent_p.N318N	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	318	LRR 13.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
NRBP2	340371	broad.mit.edu	37	8	144918357	144918357	+	Intron	SNP	C	T	T	rs138228610	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144918357C>T	uc011lkt.1	-						NRBP2_uc003yzv.2_Intron|NRBP2_uc003yzz.1_Intron|NRBP2_uc003yzw.2_Intron|NRBP2_uc010mfl.2_Intron|NRBP2_uc010mfm.2_Intron|NRBP2_uc011lks.1_Intron|NRBP2_uc003yzy.2_Intron	NM_178564	NP_848659			nuclear receptor binding protein 2						negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)															---	---	---	---
PLEC	5339	broad.mit.edu	37	8	144998018	144998018	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:144998018G>A	uc003zaf.1	-	31	6660	c.6490C>T	c.(6490-6492)CGA>TGA	p.R2164*	PLEC_uc003zab.1_Nonsense_Mutation_p.R2027*|PLEC_uc003zac.1_Nonsense_Mutation_p.R2031*|PLEC_uc003zad.2_Nonsense_Mutation_p.R2027*|PLEC_uc003zae.1_Nonsense_Mutation_p.R1995*|PLEC_uc003zag.1_Nonsense_Mutation_p.R2005*|PLEC_uc003zah.2_Nonsense_Mutation_p.R2013*|PLEC_uc003zaj.2_Nonsense_Mutation_p.R2054*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2164	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9																		---	---	---	---
GRINA	2907	broad.mit.edu	37	8	145066726	145066726	+	Missense_Mutation	SNP	C	T	T	rs145548367		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145066726C>T	uc003zan.1	+	6	1082	c.916C>T	c.(916-918)CGC>TGC	p.R306C	GRINA_uc003zao.1_Missense_Mutation_p.R306C|GRINA_uc003zap.1_Missense_Mutation_p.R306C	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	306						integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)															---	---	---	---
HEATR7A	727957	broad.mit.edu	37	8	145234370	145234370	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145234370T>C	uc003zbk.3	+	5	418	c.181T>C	c.(181-183)TAC>CAC	p.Y61H	HEATR7A_uc003zbg.2_Missense_Mutation_p.Y61H|HEATR7A_uc003zbh.3_Missense_Mutation_p.Y61H|HEATR7A_uc003zbi.3_Missense_Mutation_p.Y61H|HEATR7A_uc011lla.1_Missense_Mutation_p.Y61H|HEATR7A_uc010mft.2_Missense_Mutation_p.Y61H	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	61							binding				0																		---	---	---	---
KIFC2	90990	broad.mit.edu	37	8	145698298	145698298	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:145698298G>A	uc003zcz.2	+	17	2047	c.1982G>A	c.(1981-1983)CGC>CAC	p.R661H	KIFC2_uc003zda.2_Missense_Mutation_p.R49H	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	661	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)															---	---	---	---
COMMD5	28991	broad.mit.edu	37	8	146076123	146076123	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr8:146076123G>A	uc003zem.2	-	2	732	c.601C>T	c.(601-603)CGG>TGG	p.R201W	COMMD5_uc003zel.1_RNA|COMMD5_uc003zen.2_Missense_Mutation_p.R201W|COMMD5_uc003zeo.3_Missense_Mutation_p.R201W|COMMD5_uc010mgf.2_Missense_Mutation_p.R201W	NM_001081004	NP_001074473	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	201	COMM.					nucleus	protein binding			ovary(1)	1	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)															---	---	---	---
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961			COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)														---	---	---	---
VLDLR	7436	broad.mit.edu	37	9	2646515	2646515	+	Nonsense_Mutation	SNP	C	T	T	rs141396971		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:2646515C>T	uc003zhk.1	+	11	2063	c.1666C>T	c.(1666-1668)CGA>TGA	p.R556*	VLDLR_uc003zhl.1_Nonsense_Mutation_p.R556*|VLDLR_uc003zhm.1_RNA|VLDLR_uc003zhn.1_Nonsense_Mutation_p.R515*	NM_003383	NP_003374	P98155	VLDLR_HUMAN	very low density lipoprotein receptor isoform a	556	LDL-receptor class B 3.|Extracellular (Potential).				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)														---	---	---	---
MPDZ	8777	broad.mit.edu	37	9	13112118	13112118	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:13112118T>C	uc010mhy.2	-	41	5593	c.5542A>G	c.(5542-5544)ATC>GTC	p.I1848V	MPDZ_uc003zkx.3_Intron|MPDZ_uc003zky.3_Missense_Mutation_p.I411V|MPDZ_uc010mib.2_Missense_Mutation_p.I582V|MPDZ_uc010mhx.2_Missense_Mutation_p.I699V|MPDZ_uc011lmm.1_Missense_Mutation_p.I736V|MPDZ_uc003zkz.3_Missense_Mutation_p.I570V|MPDZ_uc010mhz.2_Missense_Mutation_p.I1844V|MPDZ_uc011lmn.1_Missense_Mutation_p.I1815V|MPDZ_uc003zlb.3_Missense_Mutation_p.I1848V	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1877	PDZ 12.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)														---	---	---	---
NFIB	4781	broad.mit.edu	37	9	14125655	14125655	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14125655C>T	uc003zle.2	-	7	1471	c.1036G>A	c.(1036-1038)GGA>AGA	p.G346R	NFIB_uc003zld.2_Missense_Mutation_p.G94R|NFIB_uc003zlf.2_Missense_Mutation_p.G346R|NFIB_uc011lmo.1_Missense_Mutation_p.G346R	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	346					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)				T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								---	---	---	---
ZDHHC21	340481	broad.mit.edu	37	9	14662273	14662273	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14662273C>T	uc003zli.2	-	6	775	c.305G>A	c.(304-306)CGT>CAT	p.R102H	ZDHHC21_uc003zlg.1_Intron	NM_178566	NP_848661	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	102	DHHC-type.				nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(50;4.31e-06)														---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14776179	14776179	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14776179G>A	uc003zlm.2	-	25	5055	c.4465C>T	c.(4465-4467)CGG>TGG	p.R1489W	FREM1_uc010mic.2_Intron|FREM1_uc003zlk.2_5'Flank|FREM1_uc003zll.2_Missense_Mutation_p.R25W	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1489	CSPG 11.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
FREM1	158326	broad.mit.edu	37	9	14842482	14842482	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:14842482G>T	uc003zlm.2	-	9	2160	c.1570C>A	c.(1570-1572)CTC>ATC	p.L524I	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	524	CSPG 3.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)														---	---	---	---
CNTLN	54875	broad.mit.edu	37	9	17235698	17235698	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:17235698C>T	uc003zmz.2	+	4	603	c.577C>T	c.(577-579)CGG>TGG	p.R193W	CNTLN_uc003zmx.3_Missense_Mutation_p.R193W|CNTLN_uc003zmy.2_Missense_Mutation_p.R193W|CNTLN_uc010mio.2_5'Flank	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	193						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)														---	---	---	---
DENND4C	55667	broad.mit.edu	37	9	19326059	19326059	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:19326059C>T	uc003znq.2	+						DENND4C_uc011lnc.1_Intron	NM_017925	NP_060395			DENN/MADD domain containing 4C							integral to membrane				ovary(1)|skin(1)	2																		---	---	---	---
LINGO2	158038	broad.mit.edu	37	9	27949660	27949660	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:27949660T>C	uc003zqu.1	-	2	1204	c.1010A>G	c.(1009-1011)GAA>GGA	p.E337G	LINGO2_uc010mjf.1_Missense_Mutation_p.E337G|LINGO2_uc003zqv.1_Missense_Mutation_p.E337G	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	337	Extracellular (Potential).|LRR 12.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)														---	---	---	---
UNC13B	10497	broad.mit.edu	37	9	35386181	35386181	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35386181C>A	uc003zwq.2	+	23	3030	c.2738C>A	c.(2737-2739)CCT>CAT	p.P913H	UNC13B_uc003zwr.2_Missense_Mutation_p.P913H	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	913					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
RUSC2	9853	broad.mit.edu	37	9	35547647	35547647	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35547647G>A	uc003zww.2	+	2	1384	c.1129G>A	c.(1129-1131)GCT>ACT	p.A377T	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.A377T	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	377						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
TESK1	7016	broad.mit.edu	37	9	35607366	35607366	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35607366G>A	uc003zxa.2	+	5	916	c.580G>A	c.(580-582)GTG>ATG	p.V194M	TESK1_uc003zwz.1_Intron|TESK1_uc010mks.2_Intron	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	194	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)															---	---	---	---
NPR2	4882	broad.mit.edu	37	9	35792488	35792488	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35792488C>T	uc003zyd.2	+	1	83	c.83C>T	c.(82-84)GCG>GTG	p.A28V	NPR2_uc010mlb.2_Missense_Mutation_p.A28V	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	28	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)													---	---	---	---
TMEM8B	51754	broad.mit.edu	37	9	35846378	35846378	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:35846378G>A	uc003zym.2	+	9	1512	c.497G>A	c.(496-498)CGG>CAG	p.R166Q	TMEM8B_uc003zyk.2_Missense_Mutation_p.R166Q|TMEM8B_uc003zyl.2_Missense_Mutation_p.R333Q|TMEM8B_uc003zyn.2_Silent_p.S61S|TMEM8B_uc003zyo.2_Missense_Mutation_p.R166Q	NM_001042589	NP_001036054	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B isoform a	166	Extracellular (Potential).				cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			ovary(1)	1																		---	---	---	---
ZCCHC7	84186	broad.mit.edu	37	9	37354736	37354736	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37354736G>A	uc003zzq.2	+	8	1286	c.1113G>A	c.(1111-1113)CCG>CCA	p.P371P	ZCCHC7_uc011lqh.1_Silent_p.P81P|ZCCHC7_uc011lqi.1_Silent_p.P370P|ZCCHC7_uc010mlt.2_Silent_p.P370P	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	371							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)														---	---	---	---
ZBTB5	9925	broad.mit.edu	37	9	37442433	37442433	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:37442433C>T	uc003zzx.2	-	2	316	c.116G>A	c.(115-117)CGC>CAC	p.R39H		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	39	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)														---	---	---	---
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2																		---	---	---	---
TMEM2	23670	broad.mit.edu	37	9	74319518	74319518	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:74319518A>G	uc011lsa.1	-	18	3727	c.3187T>C	c.(3187-3189)TTC>CTC	p.F1063L	TMEM2_uc011lrz.1_Missense_Mutation_p.F56L|TMEM2_uc010mos.2_Missense_Mutation_p.F1000L|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1063						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)														---	---	---	---
TRPM6	140803	broad.mit.edu	37	9	77377717	77377717	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:77377717C>T	uc004ajl.1	-	26	4108	c.3870G>A	c.(3868-3870)CGG>CGA	p.R1290R	TRPM6_uc004ajk.1_Silent_p.R1285R|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Silent_p.R246R	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1290	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8																		---	---	---	---
AGTPBP1	23287	broad.mit.edu	37	9	88248183	88248183	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:88248183C>T	uc011ltd.1	-	13	1442	c.1409G>A	c.(1408-1410)GGC>GAC	p.G470D	AGTPBP1_uc004aod.3_Missense_Mutation_p.G96D|AGTPBP1_uc011ltc.1_Missense_Mutation_p.G368D|AGTPBP1_uc010mqc.2_Missense_Mutation_p.G430D|AGTPBP1_uc011lte.1_Missense_Mutation_p.G482D	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	470					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7																		---	---	---	---
NOL8	55035	broad.mit.edu	37	9	95076713	95076713	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95076713G>A	uc004arv.2	-	7	2531	c.2194C>T	c.(2194-2196)CGG>TGG	p.R732W	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.R664W	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	732					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1																		---	---	---	---
NINJ1	4814	broad.mit.edu	37	9	95887239	95887239	+	Missense_Mutation	SNP	G	A	A	rs138077782		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:95887239G>A	uc004atg.3	-	3	481	c.410C>T	c.(409-411)ACG>ATG	p.T137M	NINJ1_uc004ath.3_Missense_Mutation_p.T87M	NM_004148	NP_004139	Q92982	NINJ1_HUMAN	ninjurin 1	137	Helical; (Potential).				cell adhesion|nervous system development|tissue regeneration	integral to membrane				kidney(1)	1																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	96009888	96009888	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96009888G>A	uc004ati.1	+	7	1606	c.1606G>A	c.(1606-1608)GTG>ATG	p.V536M	WNK2_uc011lud.1_Missense_Mutation_p.V536M|WNK2_uc004atj.2_Missense_Mutation_p.V536M|WNK2_uc004atk.2_Missense_Mutation_p.V173M|WNK2_uc010mrc.1_Missense_Mutation_p.V536M|WNK2_uc010mrd.1_Missense_Mutation_p.V173M	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	536					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
WNK2	65268	broad.mit.edu	37	9	96024184	96024184	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96024184C>T	uc004ati.1	+	12	3155	c.3155C>T	c.(3154-3156)CCG>CTG	p.P1052L	WNK2_uc011lud.1_Missense_Mutation_p.P1052L|WNK2_uc004atj.2_Missense_Mutation_p.P1052L|WNK2_uc004atk.2_Missense_Mutation_p.P689L	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1052					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12																		---	---	---	---
PHF2	5253	broad.mit.edu	37	9	96437282	96437282	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:96437282C>T	uc004aub.2	+	19	2847	c.2700C>T	c.(2698-2700)GAC>GAT	p.D900D	PHF2_uc011lug.1_Silent_p.D783D|PHF2_uc004auc.2_Silent_p.D320D	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	900					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)														---	---	---	---
HIATL1	84641	broad.mit.edu	37	9	97203361	97203361	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:97203361C>T	uc004aur.2	+	5	759	c.490C>T	c.(490-492)CGA>TGA	p.R164*	HIATL1_uc011luh.1_Nonsense_Mutation_p.R99*	NM_032558	NP_115947	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	164	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)																---	---	---	---
PTCH1	5727	broad.mit.edu	37	9	98241348	98241348	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:98241348T>C	uc004avk.3	-	8	1337	c.1149A>G	c.(1147-1149)TCA>TCG	p.S383S	PTCH1_uc010mro.2_Silent_p.S232S|PTCH1_uc010mrp.2_Silent_p.S232S|PTCH1_uc010mrq.2_Silent_p.S232S|PTCH1_uc004avl.3_Silent_p.S232S|PTCH1_uc010mrr.2_Silent_p.S317S|PTCH1_uc004avm.3_Silent_p.S382S|PTCH1_uc010mrs.1_Silent_p.S103S	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	383	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)												Basal_Cell_Nevus_syndrome				---	---	---	---
HSD17B3	3293	broad.mit.edu	37	9	99064279	99064279	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99064279C>T	uc004awa.1	-	1	156	c.108G>A	c.(106-108)TGG>TGA	p.W36*	HSD17B3_uc010msc.1_Nonsense_Mutation_p.W36*	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	36					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)													---	---	---	---
ZNF510	22869	broad.mit.edu	37	9	99521474	99521474	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:99521474A>G	uc004awn.1	-	6	1827	c.1638T>C	c.(1636-1638)TGT>TGC	p.C546C	ZNF510_uc004awo.1_Silent_p.C546C	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	546	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
ANKS6	203286	broad.mit.edu	37	9	101552652	101552652	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:101552652A>G	uc004ayu.2	-	2	617	c.596T>C	c.(595-597)ATC>ACC	p.I199T	ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	199	ANK 5.									ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)																---	---	---	---
ERP44	23071	broad.mit.edu	37	9	102784435	102784435	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:102784435C>T	uc004bam.2	-	5	568	c.360G>A	c.(358-360)AAG>AAA	p.K120K	ERP44_uc010msy.2_RNA|ERP44_uc010msz.2_Silent_p.K120K	NM_015051	NP_055866	Q9BS26	ERP44_HUMAN	thioredoxin domain containing 4 (endoplasmic	120	Thioredoxin.				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity				0																		---	---	---	---
TNC	3371	broad.mit.edu	37	9	117849113	117849113	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:117849113G>A	uc004bjj.3	-	3	1259	c.897C>T	c.(895-897)TGC>TGT	p.C299C	TNC_uc010mvf.2_Silent_p.C299C	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	299	EGF-like 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7																		---	---	---	---
CDK5RAP2	55755	broad.mit.edu	37	9	123298694	123298694	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123298694G>A	uc004bkf.2	-	7	799	c.618C>T	c.(616-618)CAC>CAT	p.H206H	CDK5RAP2_uc004bkg.2_Silent_p.H206H|CDK5RAP2_uc011lxw.1_Translation_Start_Site|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Translation_Start_Site|CDK5RAP2_uc011lya.1_Translation_Start_Site|CDK5RAP2_uc004bkh.1_Silent_p.H206H|CDK5RAP2_uc004bki.2_Silent_p.H5H	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	206					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4																		---	---	---	---
PSMD5	5711	broad.mit.edu	37	9	123593733	123593733	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:123593733A>G	uc004bko.2	-	4	456	c.437T>C	c.(436-438)ATC>ACC	p.I146T	PSMD5_uc011lye.1_Intron	NM_005047	NP_005038	Q16401	PSMD5_HUMAN	proteasome 26S non-ATPase subunit 5	146					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding				0																		---	---	---	---
OR1B1	347169	broad.mit.edu	37	9	125391779	125391779	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125391779C>T	uc011lyz.1	-	1	36	c.36G>A	c.(34-36)CCG>CCA	p.P12P		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0																		---	---	---	---
OR5C1	392391	broad.mit.edu	37	9	125551337	125551337	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125551337C>T	uc011lzd.1	+	1	126	c.126C>T	c.(124-126)AGC>AGT	p.S42S		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1																		---	---	---	---
RC3H2	54542	broad.mit.edu	37	9	125617540	125617540	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:125617540C>T	uc010mwc.1	-	15	2979	c.2738G>A	c.(2737-2739)CGT>CAT	p.R913H	RC3H2_uc004bnc.2_RNA|RC3H2_uc004bnd.1_Missense_Mutation_p.R913H|RC3H2_uc004bne.3_Missense_Mutation_p.R913H	NM_001100588	NP_001094058	Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type zinc finger domains 2	913						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			ovary(2)|lung(2)	4																		---	---	---	---
OLFML2A	169611	broad.mit.edu	37	9	127549469	127549469	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:127549469C>T	uc004bov.2	+	2	419	c.306C>T	c.(304-306)AAC>AAT	p.N102N	OLFML2A_uc010mwr.1_Silent_p.N102N	NM_182487	NP_872293	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A precursor	102											0																		---	---	---	---
MAPKAP1	79109	broad.mit.edu	37	9	128419995	128419995	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:128419995G>A	uc004bpv.2	-	4	766	c.433C>T	c.(433-435)CGC>TGC	p.R145C	MAPKAP1_uc011lzv.1_Translation_Start_Site|MAPKAP1_uc004bpw.2_Translation_Start_Site|MAPKAP1_uc004bpx.2_Translation_Start_Site|MAPKAP1_uc004bpy.2_Missense_Mutation_p.R145C|MAPKAP1_uc004bpz.2_Missense_Mutation_p.R145C|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc004bqa.2_Missense_Mutation_p.R145C|MAPKAP1_uc010mxc.1_Translation_Start_Site	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	145	Interaction with MAP3K2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4																		---	---	---	---
TOR2A	27433	broad.mit.edu	37	9	130495627	130495627	+	Intron	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130495627G>C	uc004brs.3	-						TOR2A_uc004brt.3_Intron|TOR2A_uc004brw.3_Silent_p.G210G|TOR2A_uc011maj.1_3'UTR|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_Intron	NM_001085347	NP_001078816			torsin family 2, member A isoform a						chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0																		---	---	---	---
ST6GALNAC6	30815	broad.mit.edu	37	9	130653011	130653011	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130653011C>T	uc004bso.1	-	5	728	c.609G>A	c.(607-609)GCG>GCA	p.A203A	ST6GALNAC6_uc004bsn.1_Silent_p.A169A|ST6GALNAC6_uc011man.1_Intron|ST6GALNAC6_uc004bsp.1_Silent_p.A203A|ST6GALNAC6_uc004bsq.1_Silent_p.A169A|ST6GALNAC6_uc004bsr.2_Silent_p.A169A|ST6GALNAC6_uc010mxp.1_RNA	NM_013443	NP_038471	Q969X2	SIA7F_HUMAN	sialytransferase 7F	203	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane|plasma membrane					0																		---	---	---	---
PTGES2	80142	broad.mit.edu	37	9	130889772	130889772	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:130889772C>T	uc004bti.2	-	1	703	c.225G>A	c.(223-225)ACG>ACA	p.T75T	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Intron|PTGES2_uc004btl.2_Intron|PTGES2_uc004btm.2_Intron|LOC389791_uc004btn.2_5'Flank	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	75	Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0																		---	---	---	---
CCBL1	883	broad.mit.edu	37	9	131599998	131599998	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131599998A>C	uc004bwh.2	-	6	718	c.533T>G	c.(532-534)CTG>CGG	p.L178R	CCBL1_uc004bwf.2_Missense_Mutation_p.L212R|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.L178R|CCBL1_uc004bwj.2_Missense_Mutation_p.L128R|CCBL1_uc011mbl.1_Missense_Mutation_p.L272R|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Intron	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	178					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)													---	---	---	---
NUP188	23511	broad.mit.edu	37	9	131745254	131745254	+	Silent	SNP	G	A	A	rs148151804	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:131745254G>A	uc004bws.1	+	17	1765	c.1743G>A	c.(1741-1743)TCG>TCA	p.S581S	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	581					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7																		---	---	---	---
NCS1	23413	broad.mit.edu	37	9	132980177	132980177	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:132980177C>T	uc004bzi.2	+	3	242	c.156C>T	c.(154-156)TAC>TAT	p.Y52Y	NCS1_uc010myz.1_Silent_p.Y34Y	NM_014286	NP_055101	P62166	NCS1_HUMAN	frequenin homolog isoform 1	52	EF-hand 1.				negative regulation of calcium ion transport via voltage-gated calcium channel activity|regulation of neuron projection development	cell junction|Golgi cisterna membrane|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|protein binding				0																		---	---	---	---
NUP214	8021	broad.mit.edu	37	9	134010375	134010375	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:134010375A>G	uc004cag.2	+	8	1033	c.922A>G	c.(922-924)AGT>GGT	p.S308G	NUP214_uc004cah.2_Missense_Mutation_p.S308G|NUP214_uc004caf.1_Missense_Mutation_p.S308G	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	308					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)				T	DEK|SET|ABL1	AML|T-ALL								---	---	---	---
NTNG2	84628	broad.mit.edu	37	9	135073571	135073571	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135073571C>T	uc004cbh.2	+	3	1208	c.432C>T	c.(430-432)GGC>GGT	p.G144G		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	144	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)														---	---	---	---
SETX	23064	broad.mit.edu	37	9	135224793	135224793	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:135224793G>A	uc004cbk.2	-	3	206	c.23C>T	c.(22-24)ACG>ATG	p.T8M		NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	8					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)														---	---	---	---
C9orf96	169436	broad.mit.edu	37	9	136256580	136256580	+	Intron	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136256580G>T	uc004cdk.2	+						C9orf96_uc004cdl.2_Intron	NM_153710	NP_714921			hypothetical protein LOC169436								ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)														---	---	---	---
SARDH	1757	broad.mit.edu	37	9	136568075	136568075	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136568075T>G	uc004cep.3	-	13	1765	c.1631A>C	c.(1630-1632)GAC>GCC	p.D544A	SARDH_uc004ceo.2_Missense_Mutation_p.D544A|SARDH_uc011mdn.1_Missense_Mutation_p.D544A|SARDH_uc011mdo.1_Missense_Mutation_p.D376A|SARDH_uc004cen.2_5'UTR	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	544					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)														---	---	---	---
SARDH	1757	broad.mit.edu	37	9	136594899	136594899	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:136594899G>A	uc004cep.3	-	6	1037	c.903C>T	c.(901-903)ATC>ATT	p.I301I	SARDH_uc004ceo.2_Silent_p.I301I|SARDH_uc011mdn.1_Silent_p.I301I|SARDH_uc011mdo.1_Silent_p.I133I	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	301					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)														---	---	---	---
MRPS2	51116	broad.mit.edu	37	9	138395799	138395799	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138395799C>T	uc004cfv.3	+	4	785	c.711C>T	c.(709-711)CCC>CCT	p.P237P	MRPS2_uc004cfw.3_Silent_p.P147P|MRPS2_uc004cfx.3_Silent_p.P152P|MRPS2_uc010nat.2_Silent_p.P218P|uc004cfy.2_Intron	NM_016034	NP_057118	Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	237					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)														---	---	---	---
KCNT1	57582	broad.mit.edu	37	9	138651528	138651528	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138651528C>A	uc011mdq.1	+	11	932	c.858C>A	c.(856-858)ACC>ACA	p.T286T	KCNT1_uc011mdr.1_Silent_p.T113T|KCNT1_uc010nbf.2_Silent_p.T241T|KCNT1_uc004cgo.1_Silent_p.T35T	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	286						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)														---	---	---	---
CAMSAP1	157922	broad.mit.edu	37	9	138712718	138712718	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:138712718G>A	uc004cgr.3	-	11	3789	c.3789C>T	c.(3787-3789)GGC>GGT	p.G1263G	CAMSAP1_uc004cgq.3_Silent_p.G1153G|CAMSAP1_uc010nbg.2_Silent_p.G985G	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	1263						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)														---	---	---	---
LHX3	8022	broad.mit.edu	37	9	139096805	139096805	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139096805G>A	uc004cha.2	-	1	151	c.54C>T	c.(52-54)GCC>GCT	p.A18A	LHX3_uc004cgz.2_5'Flank	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	18					inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)														---	---	---	---
SEC16A	9919	broad.mit.edu	37	9	139358971	139358971	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139358971A>G	uc004chx.2	-	9	4656	c.4347T>C	c.(4345-4347)CAT>CAC	p.H1449H	SEC16A_uc004chv.3_Silent_p.H839H|SEC16A_uc004chw.2_Silent_p.H1449H|SEC16A_uc010nbn.2_Silent_p.H1449H	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1271					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)														---	---	---	---
C9orf172	389813	broad.mit.edu	37	9	139740978	139740978	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:139740978C>T	uc011meh.1	+	1	2112	c.2112C>T	c.(2110-2112)GAC>GAT	p.D704D	PHPT1_uc004cjp.2_5'Flank|PHPT1_uc011mei.1_5'Flank|PHPT1_uc004cjq.3_5'Flank	NM_001080482	NP_001073951	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	704											0																		---	---	---	---
PNPLA7	375775	broad.mit.edu	37	9	140409897	140409897	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140409897G>A	uc004cnf.2	-	11	1421	c.1084C>T	c.(1084-1086)CGC>TGC	p.R362C	PNPLA7_uc011mfa.1_Missense_Mutation_p.R94C|PNPLA7_uc010ncj.1_Missense_Mutation_p.R387C	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	362					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)														---	---	---	---
CACNA1B	774	broad.mit.edu	37	9	140878583	140878583	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr9:140878583G>A	uc004cog.2	+						CACNA1B_uc011mfd.1_Intron	NM_000718	NP_000709			calcium channel, voltage-dependent, N type,						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)													---	---	---	---
SFMBT2	57713	broad.mit.edu	37	10	7269848	7269848	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:7269848G>A	uc009xio.1	-	10	1263	c.1172C>T	c.(1171-1173)GCG>GTG	p.A391V	SFMBT2_uc001ijn.1_Missense_Mutation_p.A391V|SFMBT2_uc010qay.1_Missense_Mutation_p.A391V	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	391	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8																		---	---	---	---
CAMK1D	57118	broad.mit.edu	37	10	12803096	12803096	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:12803096C>T	uc001ilo.2	+						CAMK1D_uc001iln.2_Intron	NM_153498	NP_705718			calcium/calmodulin-dependent protein kinase ID							calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)														---	---	---	---
OPTN	10133	broad.mit.edu	37	10	13154615	13154615	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:13154615T>G	uc001ilu.1	+	6	970	c.532T>G	c.(532-534)TTT>GTT	p.F178V	OPTN_uc001ilv.1_Missense_Mutation_p.F178V|OPTN_uc001ilw.1_Missense_Mutation_p.F178V|OPTN_uc001ilx.1_Missense_Mutation_p.F178V|OPTN_uc001ily.1_Missense_Mutation_p.F178V|OPTN_uc010qbr.1_Missense_Mutation_p.F121V|OPTN_uc001ilz.1_Missense_Mutation_p.F178V	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	178	Interaction with Rab8.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2																		---	---	---	---
SLC39A12	221074	broad.mit.edu	37	10	18276431	18276431	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:18276431G>A	uc001ipo.2	+	7	1393	c.1120G>A	c.(1120-1122)GTC>ATC	p.V374I	SLC39A12_uc001ipn.2_Missense_Mutation_p.V374I|SLC39A12_uc001ipp.2_Missense_Mutation_p.V374I|SLC39A12_uc010qck.1_Missense_Mutation_p.V240I	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),	374	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2																		---	---	---	---
MYO3A	53904	broad.mit.edu	37	10	26463094	26463094	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:26463094A>G	uc001isn.2	+	30	4261	c.3901A>G	c.(3901-3903)ATG>GTG	p.M1301V	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1301					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18																		---	---	---	---
PDSS1	23590	broad.mit.edu	37	10	26998620	26998620	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:26998620T>C	uc001isv.2	+	5	436	c.390T>C	c.(388-390)GAT>GAC	p.D130D	PDSS1_uc001isw.2_Silent_p.D130D	NM_014317	NP_055132	Q5T2R2	DPS1_HUMAN	prenyl diphosphate synthase, subunit 1	130					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity				0																		---	---	---	---
MPP7	143098	broad.mit.edu	37	10	28378660	28378660	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:28378660C>T	uc001iua.1	-	14	1467	c.1063G>A	c.(1063-1065)GAA>AAA	p.E355K	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.E355K|MPP7_uc009xla.2_Missense_Mutation_p.E355K|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	355					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1																		---	---	---	---
SVIL	6840	broad.mit.edu	37	10	29782225	29782225	+	Missense_Mutation	SNP	G	A	A	rs141855067		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:29782225G>A	uc001iut.1	-	21	4690	c.3937C>T	c.(3937-3939)CGC>TGC	p.R1313C	SVIL_uc010qdw.1_Missense_Mutation_p.R227C|SVIL_uc001iuu.1_Missense_Mutation_p.R887C|SVIL_uc009xlc.2_Missense_Mutation_p.R105C	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1313					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)																---	---	---	---
ANKRD30A	91074	broad.mit.edu	37	10	37430911	37430911	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:37430911G>A	uc001iza.1	+	7	1017	c.918G>A	c.(916-918)ACG>ACA	p.T306T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	362						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9																		---	---	---	---
ZNF488	118738	broad.mit.edu	37	10	48371037	48371037	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:48371037C>T	uc001jex.2	+	2	667	c.505C>T	c.(505-507)CGA>TGA	p.R169*	ZNF488_uc001jey.2_Nonsense_Mutation_p.R62*	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1																		---	---	---	---
ARHGAP22	58504	broad.mit.edu	37	10	49687682	49687682	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:49687682C>T	uc001jgt.2	-	4	745	c.448G>A	c.(448-450)GGA>AGA	p.G150R	ARHGAP22_uc001jgs.2_Missense_Mutation_p.G60R|ARHGAP22_uc001jgu.2_Missense_Mutation_p.G150R|ARHGAP22_uc010qgl.1_Intron|ARHGAP22_uc010qgm.1_Missense_Mutation_p.G156R|ARHGAP22_uc001jgv.2_5'UTR|uc001jgw.2_5'Flank	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	150					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1																		---	---	---	---
SLC18A3	6572	broad.mit.edu	37	10	50819159	50819159	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:50819159G>T	uc001jhw.2	+	1	813	c.373G>T	c.(373-375)GGG>TGG	p.G125W	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	125	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2																		---	---	---	---
PARG	8505	broad.mit.edu	37	10	51581263	51581263	+	Intron	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51581263T>C	uc001jih.2	-						uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Intron|NCOA4_uc010qhd.1_Intron|NCOA4_uc001jis.3_Intron|NCOA4_uc010qhe.1_Intron|NCOA4_uc010qhf.1_Intron|NCOA4_uc001jit.2_Intron|NCOA4_uc009xoo.2_Intron	NM_003631	NP_003622			poly (ADP-ribose) glycohydrolase						carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity			ovary(2)	2				Epithelial(53;0.213)														---	---	---	---
NCOA4	8031	broad.mit.edu	37	10	51582227	51582227	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:51582227T>C	uc001jis.3	+	6	728	c.525T>C	c.(523-525)ATT>ATC	p.I175I	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Silent_p.I191I|NCOA4_uc010qhd.1_Silent_p.I191I|NCOA4_uc010qhe.1_Silent_p.I75I|NCOA4_uc010qhf.1_Silent_p.I9I|NCOA4_uc001jit.2_Silent_p.I175I|NCOA4_uc009xoo.2_Silent_p.I175I	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	175					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2								T	RET	papillary thyroid 								---	---	---	---
A1CF	29974	broad.mit.edu	37	10	52570854	52570854	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:52570854T>C	uc001jjj.2	-	11	1618	c.1430A>G	c.(1429-1431)CAG>CGG	p.Q477R	A1CF_uc010qhn.1_Missense_Mutation_p.Q477R|A1CF_uc001jji.2_Missense_Mutation_p.Q469R|A1CF_uc001jjh.2_Missense_Mutation_p.Q477R|A1CF_uc010qho.1_Missense_Mutation_p.Q485R|A1CF_uc009xov.2_Missense_Mutation_p.Q469R	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	477					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1																		---	---	---	---
ANK3	288	broad.mit.edu	37	10	61831671	61831671	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:61831671G>A	uc001jky.2	-	37	9160	c.8968C>T	c.(8968-8970)CTA>TTA	p.L2990L	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2990					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19																		---	---	---	---
RHOBTB1	9886	broad.mit.edu	37	10	62652608	62652608	+	Missense_Mutation	SNP	C	T	T	rs141139124	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:62652608C>T	uc001jli.2	-	6	880	c.442G>A	c.(442-444)GAC>AAC	p.D148N	RHOBTB1_uc001jlh.2_Missense_Mutation_p.D148N|RHOBTB1_uc001jlj.2_Missense_Mutation_p.D148N|RHOBTB1_uc001jlk.2_Missense_Mutation_p.D148N|RHOBTB1_uc009xpe.1_Intron	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	148	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)																	---	---	---	---
ARID5B	84159	broad.mit.edu	37	10	63852248	63852248	+	Missense_Mutation	SNP	C	G	G	rs145564601		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:63852248C>G	uc001jlt.1	+	10	3052	c.3026C>G	c.(3025-3027)GCG>GGG	p.A1009G		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1009					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)																	---	---	---	---
HERC4	26091	broad.mit.edu	37	10	69714858	69714858	+	Missense_Mutation	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:69714858A>T	uc001jng.3	-	19	2390	c.2079T>A	c.(2077-2079)AAT>AAA	p.N693K	HERC4_uc009xpq.2_Missense_Mutation_p.N226K|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.N685K|HERC4_uc009xpr.2_Missense_Mutation_p.N693K|HERC4_uc001jni.3_Missense_Mutation_p.N429K	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	693					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
KIAA1274	27143	broad.mit.edu	37	10	72299009	72299009	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:72299009G>A	uc001jrd.3	+						KIAA1274_uc001jre.3_5'Flank	NM_014431	NP_055246			KIAA1274											ovary(2)|central_nervous_system(1)	3																		---	---	---	---
PPP3CB	5532	broad.mit.edu	37	10	75239200	75239200	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:75239200A>G	uc001jue.2	-	2	296	c.161T>C	c.(160-162)GTT>GCT	p.V54A	PPP3CB_uc001juf.2_Missense_Mutation_p.V54A|PPP3CB_uc001jug.2_Missense_Mutation_p.V54A|PPP3CB_uc001jui.2_Missense_Mutation_p.V54A|PPP3CB_uc001juh.2_5'UTR	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	54	Catalytic.									skin(1)	1	Prostate(51;0.0119)																	---	---	---	---
MYST4	23522	broad.mit.edu	37	10	76744931	76744931	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:76744931C>T	uc001jwn.1	+	12	2960	c.2467C>T	c.(2467-2469)CCA>TCA	p.P823S	MYST4_uc001jwm.1_Missense_Mutation_p.P531S|MYST4_uc001jwo.1_Missense_Mutation_p.P531S|MYST4_uc001jwp.1_Missense_Mutation_p.P640S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	823	Catalytic.|Interaction with BRPF1.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)							T	CREBBP	AML								---	---	---	---
KCNMA1	3778	broad.mit.edu	37	10	78651358	78651358	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:78651358C>T	uc001jxn.2	-	26	3444	c.3267G>A	c.(3265-3267)CCG>CCA	p.P1089P	KCNMA1_uc001jxj.2_Silent_p.P1035P|KCNMA1_uc001jxk.1_Silent_p.P707P|KCNMA1_uc009xrt.1_Silent_p.P880P|KCNMA1_uc001jxl.1_Silent_p.P714P|KCNMA1_uc001jxo.2_Silent_p.P1072P|KCNMA1_uc001jxm.2_Silent_p.P1031P|KCNMA1_uc001jxq.2_Silent_p.P1061P|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1089	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)													---	---	---	---
CDHR1	92211	broad.mit.edu	37	10	85974009	85974009	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85974009C>T	uc001kcv.2	+	17	2212	c.2212C>T	c.(2212-2214)CGG>TGG	p.R738W	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.R442W|CDHR1_uc001kcx.2_Missense_Mutation_p.R52W	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	738	Cytoplasmic (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1																		---	---	---	---
LRIT1	26103	broad.mit.edu	37	10	85997322	85997322	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:85997322G>T	uc001kcz.1	-	2	265	c.243C>A	c.(241-243)CCC>CCA	p.P81P		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	81	LRR 1.|Lumenal (Potential).					integral to endoplasmic reticulum membrane					0																		---	---	---	---
GRID1	2894	broad.mit.edu	37	10	87966268	87966268	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:87966268G>A	uc001kdl.1	-	3	474	c.373C>T	c.(373-375)CGC>TGC	p.R125C	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	125	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)										Multiple Myeloma(13;0.14)			---	---	---	---
TNKS2	80351	broad.mit.edu	37	10	93596667	93596667	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:93596667C>T	uc001khp.2	+							NM_025235	NP_079511			tankyrase, TRF1-interacting ankyrin-related						positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)																---	---	---	---
CYP26C1	340665	broad.mit.edu	37	10	94825964	94825964	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94825964C>T	uc010qns.1	+	5	1113	c.1113C>T	c.(1111-1113)TGC>TGT	p.C371C	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	371					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)																---	---	---	---
CYP26A1	1592	broad.mit.edu	37	10	94834065	94834065	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:94834065C>T	uc001kil.2	+	2	235	c.190C>T	c.(190-192)CGG>TGG	p.R64W	CYP26A1_uc001kik.1_5'UTR|CYP26A1_uc001kim.1_5'UTR	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	64					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)																---	---	---	---
ALDH18A1	5832	broad.mit.edu	37	10	97397084	97397084	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97397084C>T	uc001kkz.2	-	4	655	c.413G>A	c.(412-414)CGG>CAG	p.R138Q	ALDH18A1_uc001kky.2_Missense_Mutation_p.R138Q|ALDH18A1_uc010qog.1_Missense_Mutation_p.R27Q|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	138	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)													---	---	---	---
TCTN3	26123	broad.mit.edu	37	10	97423816	97423816	+	3'UTR	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:97423816T>C	uc001klb.3	-	14					TCTN3_uc001kla.3_3'UTR|TCTN3_uc010qoi.1_3'UTR	NM_015631	NP_056446			tectonic 3 isoform a precursor						apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)														---	---	---	---
UBTD1	80019	broad.mit.edu	37	10	99330045	99330045	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:99330045C>A	uc001knv.1	+	3	642	c.449C>A	c.(448-450)CCG>CAG	p.P150Q	ANKRD2_uc001knw.2_5'Flank|ANKRD2_uc009xvu.2_5'Flank	NM_024954	NP_079230	Q9HAC8	UBTD1_HUMAN	ubiquitin domain containing 1	150	Ubiquitin-like.										0		Colorectal(252;0.162)		Epithelial(162;3.04e-10)|all cancers(201;2.86e-08)														---	---	---	---
PYROXD2	84795	broad.mit.edu	37	10	100157191	100157191	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:100157191G>A	uc001kpc.2	-	6	622	c.536C>T	c.(535-537)GCG>GTG	p.A179V	PYROXD2_uc001kpb.2_RNA|PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Missense_Mutation_p.A179V|MIR1287_hsa-mir-1287|MI0006349_5'Flank	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	179							oxidoreductase activity			central_nervous_system(1)	1																		---	---	---	---
C10orf2	56652	broad.mit.edu	37	10	102749454	102749454	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102749454T>C	uc001ksf.2	+	2	1972	c.1297T>C	c.(1297-1299)TGT>CGT	p.C433R	MRPL43_uc001kry.1_5'Flank|MRPL43_uc010qpu.1_5'Flank|MRPL43_uc001krz.1_5'Flank|MRPL43_uc001ksa.1_5'Flank|MRPL43_uc001ksb.1_5'Flank|MRPL43_uc001ksd.1_5'Flank|MRPL43_uc001ksc.2_5'Flank|MRPL43_uc001kse.2_5'Flank|C10orf2_uc001ksg.2_Missense_Mutation_p.C433R|C10orf2_uc001ksi.2_5'UTR|C10orf2_uc010qpv.1_5'UTR|C10orf2_uc001ksh.2_Intron	NM_021830	NP_068602	Q96RR1	PEO1_HUMAN	twinkle isoform A	433	SF4 helicase.				cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			ovary(1)	1		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)														---	---	---	---
TLX1	3195	broad.mit.edu	37	10	102896546	102896546	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:102896546C>T	uc001ksw.2	+	3	1107	c.869C>T	c.(868-870)CCG>CTG	p.P290L		NM_005521	NP_005512	P31314	TLX1_HUMAN	T-cell leukemia homeobox 1	290						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1				Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)				T	TRB@|TRD@	T-ALL								---	---	---	---
POLL	27343	broad.mit.edu	37	10	103339389	103339389	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:103339389G>A	uc001ktg.1	-	8	2315	c.1549C>T	c.(1549-1551)CGA>TGA	p.R517*	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Nonsense_Mutation_p.R190*|POLL_uc001kte.1_Nonsense_Mutation_p.R209*|POLL_uc001kth.1_Nonsense_Mutation_p.R242*|POLL_uc001kti.1_Nonsense_Mutation_p.R517*|POLL_uc001ktj.1_Nonsense_Mutation_p.R517*|POLL_uc001ktf.2_Nonsense_Mutation_p.R425*|POLL_uc001ktk.1_Nonsense_Mutation_p.R256*|POLL_uc010qqa.1_Nonsense_Mutation_p.R256*|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Nonsense_Mutation_p.R517*|POLL_uc001ktl.2_Nonsense_Mutation_p.R429*|POLL_uc010qqc.1_Nonsense_Mutation_p.R209*	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	517					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)									DNA_polymerases_(catalytic_subunits)					---	---	---	---
NT5C2	22978	broad.mit.edu	37	10	104854154	104854154	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:104854154C>T	uc001kwo.2	-	13	1058	c.872G>A	c.(871-873)CGG>CAG	p.R291Q	NT5C2_uc010qqp.1_Missense_Mutation_p.R262Q|NT5C2_uc001kwq.2_Missense_Mutation_p.R291Q|NT5C2_uc001kwp.2_Missense_Mutation_p.R138Q	NM_012229	NP_036361	P49902	5NTC_HUMAN	5'-nucleotidase, cytosolic II	291					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|metal ion binding|nucleotide binding|protein binding				0		all_hematologic(284;0.176)|Colorectal(252;0.178)		Epithelial(162;1.33e-08)|all cancers(201;1.04e-07)|BRCA - Breast invasive adenocarcinoma(275;0.159)	Adenosine triphosphate(DB00171)|Ribavirin(DB00811)													---	---	---	---
ADD3	120	broad.mit.edu	37	10	111882009	111882009	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:111882009G>A	uc001kyt.3	+	10	1416	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K	ADD3_uc001kys.3_Missense_Mutation_p.E368K|ADD3_uc001kyu.2_Missense_Mutation_p.E368K|ADD3_uc001kyv.2_Missense_Mutation_p.E368K|ADD3_uc001kyw.2_Missense_Mutation_p.E368K|ADD3_uc001kyx.2_5'Flank	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	368						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)														---	---	---	---
ADRA2A	150	broad.mit.edu	37	10	112838876	112838876	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:112838876G>A	uc001kzo.2	+	1	2087	c.1122G>A	c.(1120-1122)GCG>GCA	p.A374A		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	359	Cytoplasmic (By similarity).			PRRGPGATGIGTPAAGPGEERVGAAKASRWRGR -> RGAG RGRRGSGRRLQGRGRSASGLPRRRAGAGG (in Ref. 1; AAA51664 and 2; AAA51665).	actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)													---	---	---	---
DCLRE1A	9937	broad.mit.edu	37	10	115608932	115608932	+	Silent	SNP	C	T	T	rs144798018		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115608932C>T	uc001law.2	-	2	2850	c.1932G>A	c.(1930-1932)CTG>CTA	p.L644L		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	644					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)									Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
ADRB1	153	broad.mit.edu	37	10	115804493	115804493	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:115804493C>T	uc001lba.2	+	1	688	c.602C>T	c.(601-603)GCG>GTG	p.A201V		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	201	Extracellular (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)													---	---	---	---
PNLIP	5406	broad.mit.edu	37	10	118327244	118327244	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:118327244C>T	uc001lcm.2	+							NM_000936	NP_000927			pancreatic lipase precursor						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)													---	---	---	---
PPAPDC1A	196051	broad.mit.edu	37	10	122348837	122348837	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:122348837C>T	uc001lev.1	+	7	991	c.639C>T	c.(637-639)ATC>ATT	p.I213I	PPAPDC1A_uc009xzl.1_Silent_p.I150I|PPAPDC1A_uc001lew.1_3'UTR|PPAPDC1A_uc001lex.1_Missense_Mutation_p.S63L|PPAPDC1A_uc001ley.1_Silent_p.I92I	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	213	Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)														---	---	---	---
DMBT1	1755	broad.mit.edu	37	10	124390712	124390712	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124390712G>A	uc001lgk.1	+	46	5980	c.5874G>A	c.(5872-5874)ACG>ACA	p.T1958T	DMBT1_uc001lgl.1_Silent_p.T1948T|DMBT1_uc001lgm.1_Silent_p.T1330T|DMBT1_uc009xzz.1_Silent_p.T1958T|DMBT1_uc010qtx.1_Silent_p.T678T|DMBT1_uc009yab.1_Silent_p.T661T|DMBT1_uc009yac.1_Silent_p.T252T	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1958	SRCR 14.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)																---	---	---	---
IKZF5	64376	broad.mit.edu	37	10	124754119	124754119	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:124754119C>T	uc001lha.2	-	5	736	c.437G>A	c.(436-438)CGC>CAC	p.R146H	IKZF5_uc001lgz.2_5'UTR	NM_022466	NP_071911	Q9H5V7	IKZF5_HUMAN	zinc finger protein, subfamily 1A, 5	146	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)														---	---	---	---
CTBP2	1488	broad.mit.edu	37	10	126714834	126714834	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:126714834C>T	uc009yak.2	-						CTBP2_uc009yal.2_Intron|CTBP2_uc001lif.3_Intron|CTBP2_uc001lih.3_Intron|CTBP2_uc001lie.3_Missense_Mutation_p.A499T	NM_001329	NP_001320			C-terminal binding protein 2 isoform 1						negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)														---	---	---	---
MKI67	4288	broad.mit.edu	37	10	129902696	129902696	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:129902696C>A	uc001lke.2	-	13	7603	c.7408G>T	c.(7408-7410)GAG>TAG	p.E2470*	MKI67_uc001lkf.2_Nonsense_Mutation_p.E2110*|MKI67_uc009yav.1_Nonsense_Mutation_p.E2045*|MKI67_uc009yaw.1_Nonsense_Mutation_p.E1620*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2470	16 X 122 AA approximate repeats.|13.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)																---	---	---	---
Unknown	0	broad.mit.edu	37	10	134671162	134671162	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134671162C>T	uc010qux.1	-	31	4684	c.4684G>A	c.(4684-4686)GCC>ACC	p.A1562T		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																														---	---	---	---
GPR123	84435	broad.mit.edu	37	10	134942441	134942441	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:134942441C>T	uc001llx.3	+	7	1545	c.1109C>T	c.(1108-1110)GCG>GTG	p.A370V	GPR123_uc001llw.2_Missense_Mutation_p.A1089V	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	370	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)														---	---	---	---
UTF1	8433	broad.mit.edu	37	10	135044937	135044937	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135044937G>A	uc001lmc.2	+	2	1032	c.1017G>A	c.(1015-1017)CCG>CCA	p.P339P		NM_003577	NP_003568	Q5T230	UTF1_HUMAN	undifferentiated embryonic cell transcription	339					male gonad development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein binding|transcription coactivator activity				0		all_cancers(35;3.05e-07)|all_epithelial(44;6.22e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)														---	---	---	---
TUBGCP2	10844	broad.mit.edu	37	10	135101642	135101642	+	Silent	SNP	G	A	A	rs145076825		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr10:135101642G>A	uc001lmg.1	-	11	2070	c.1713C>T	c.(1711-1713)GAC>GAT	p.D571D	TUBGCP2_uc001lmf.1_Silent_p.D164D|TUBGCP2_uc010qvc.1_Silent_p.D599D|TUBGCP2_uc009ybk.1_Silent_p.D571D|TUBGCP2_uc010qvd.1_Silent_p.D441D|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	571					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)														---	---	---	---
B4GALNT4	338707	broad.mit.edu	37	11	373457	373457	+	Silent	SNP	C	T	T	rs143213010		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:373457C>T	uc001lpb.2	+	7	654	c.645C>T	c.(643-645)TCC>TCT	p.S215S		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	215	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
PKP3	11187	broad.mit.edu	37	11	403637	403637	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:403637G>A	uc001lpc.2	+	10	2019	c.1943G>A	c.(1942-1944)CGC>CAC	p.R648H		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	648	ARM 7.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
RNH1	6050	broad.mit.edu	37	11	494953	494953	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:494953G>A	uc001lpk.1	-	8	2636	c.1228C>T	c.(1228-1230)CTG>TTG	p.L410L	RNH1_uc001lpl.1_Silent_p.L410L|RNH1_uc001lpm.1_Silent_p.L410L|RNH1_uc001lpn.1_Silent_p.L410L|RNH1_uc001lpo.1_Silent_p.L410L|RNH1_uc009ybw.1_RNA|RNH1_uc001lpp.1_Silent_p.L410L|RNH1_uc001lpt.1_Silent_p.L167L|RNH1_uc001lpq.1_Silent_p.L410L|RNH1_uc001lpr.1_Silent_p.L410L|RNH1_uc001lps.1_Silent_p.L410L	NM_203389	NP_976323	P13489	RINI_HUMAN	ribonuclease/angiogenin inhibitor	410	LRR 14.				mRNA catabolic process|regulation of angiogenesis	angiogenin-PRI complex|cytoplasm	protein binding|ribonuclease inhibitor activity				0		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.26e-26)|Epithelial(43;1.34e-25)|OV - Ovarian serous cystadenocarcinoma(40;5.31e-20)|BRCA - Breast invasive adenocarcinoma(625;8.01e-05)|Lung(200;0.0378)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
CDHR5	53841	broad.mit.edu	37	11	621813	621813	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:621813T>A	uc001lqj.2	-	4	509	c.404A>T	c.(403-405)GAG>GTG	p.E135V	CDHR5_uc001lqk.2_Missense_Mutation_p.E135V|CDHR5_uc009ycc.2_5'UTR|CDHR5_uc009ycd.2_Missense_Mutation_p.E135V|CDHR5_uc001lql.2_Missense_Mutation_p.E135V|CDHR5_uc001lqm.2_5'UTR|CDHR5_uc009yce.1_Intron	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	135	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0																		---	---	---	---
EPS8L2	64787	broad.mit.edu	37	11	723257	723257	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:723257G>A	uc001lqt.2	+	15	1605	c.1358G>A	c.(1357-1359)CGA>CAA	p.R453Q	EPS8L2_uc001lqu.2_Missense_Mutation_p.R453Q|EPS8L2_uc010qwk.1_Missense_Mutation_p.R469Q|EPS8L2_uc001lqv.2_Missense_Mutation_p.R408Q|EPS8L2_uc001lqw.2_Missense_Mutation_p.R65Q|EPS8L2_uc001lqx.2_Missense_Mutation_p.R65Q|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	453						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)												OREG0020659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
PDDC1	347862	broad.mit.edu	37	11	771068	771068	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:771068C>T	uc001lrc.2	-	7	606	c.581G>A	c.(580-582)CGC>CAC	p.R194H	PDDC1_uc010qwm.1_Missense_Mutation_p.R144H|PDDC1_uc001lrd.2_Intron|PDDC1_uc001lrf.1_3'UTR|PDDC1_uc001lrg.1_RNA|PDDC1_uc009ycg.2_3'UTR|PDDC1_uc010qwn.1_RNA|PDDC1_uc010qwo.1_RNA|PDDC1_uc010qwp.1_Missense_Mutation_p.R158H|PDDC1_uc010qwq.1_Missense_Mutation_p.R108H|PDDC1_uc010qwr.1_Missense_Mutation_p.R194H|PDDC1_uc010qws.1_Missense_Mutation_p.R144H	NM_182612	NP_872418	Q8NB37	PDDC1_HUMAN	Parkinson disease 7 domain containing 1	194						extracellular region					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;3.66e-26)|Epithelial(43;2.43e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-19)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)														---	---	---	---
MUC2	4583	broad.mit.edu	37	11	1092334	1092334	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1092334C>T	uc001lsx.1	+	30	4180	c.4153C>T	c.(4153-4155)CGT>TGT	p.R1385C		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1385						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)													---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1270971	1270971	+	Silent	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1270971C>G	uc009ycr.1	+	51	14406	c.14280C>G	c.(14278-14280)ACC>ACG	p.T4760T	MUC5B_uc001ltb.2_Silent_p.T4290T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4287	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
MUC5B	727897	broad.mit.edu	37	11	1271083	1271083	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:1271083C>G	uc009ycr.1	+	51	14518	c.14392C>G	c.(14392-14394)CCC>GCC	p.P4798A	MUC5B_uc001ltb.2_Missense_Mutation_p.P4328A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4325	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)														---	---	---	---
MRGPRE	116534	broad.mit.edu	37	11	3249838	3249838	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:3249838G>A	uc001lxq.3	-	2	499	c.189C>T	c.(187-189)GAC>GAT	p.D63D		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	63	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)														---	---	---	---
OR52K1	390036	broad.mit.edu	37	11	4510486	4510486	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:4510486C>A	uc001lza.1	+	1	356	c.356C>A	c.(355-357)GCC>GAC	p.A119D		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)														---	---	---	---
OR52A5	390054	broad.mit.edu	37	11	5153517	5153517	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5153517G>A	uc010qyx.1	-	1	356	c.356C>T	c.(355-357)GCA>GTA	p.A119V		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)														---	---	---	---
OR51B2	79345	broad.mit.edu	37	11	5345106	5345106	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5345106G>A	uc001mao.1	-	1	477	c.422C>T	c.(421-423)GCG>GTG	p.A141V	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
TRIM5	85363	broad.mit.edu	37	11	5686300	5686300	+	Silent	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:5686300T>G	uc001mbm.1	-	8	1478	c.1221A>C	c.(1219-1221)GGA>GGC	p.G407G	TRIM78P_uc009yer.2_Intron|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Intron|TRIM5_uc001mbo.2_Intron	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	407	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)														---	---	---	---
OR52W1	120787	broad.mit.edu	37	11	6220577	6220577	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6220577C>T	uc010qzz.1	+	1	124	c.124C>T	c.(124-126)CTG>TTG	p.L42L		NM_001005178	NP_001005178	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)														---	---	---	---
CCKBR	887	broad.mit.edu	37	11	6292284	6292284	+	Silent	SNP	G	A	A	rs149197660		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6292284G>A	uc001mcp.2	+	5	1048	c.855G>A	c.(853-855)GCG>GCA	p.A285A	CCKBR_uc001mcq.2_Silent_p.A213A|CCKBR_uc001mcr.2_Silent_p.A285A|CCKBR_uc001mcs.2_Silent_p.A354A|CCKBR_uc001mct.1_RNA	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	285	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)													---	---	---	---
RRP8	23378	broad.mit.edu	37	11	6622581	6622581	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6622581G>A	uc001med.2	-	3	794	c.715C>T	c.(715-717)CGA>TGA	p.R239*	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	239					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0																		---	---	---	---
TPP1	1200	broad.mit.edu	37	11	6637718	6637718	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:6637718C>A	uc001mel.1	-	8	964	c.903G>T	c.(901-903)CAG>CAT	p.Q301H	TPP1_uc001mek.1_Missense_Mutation_p.Q58H	NM_000391	NP_000382	O14773	TPP1_HUMAN	tripeptidyl-peptidase I preproprotein	301					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)														---	---	---	---
NLRP10	338322	broad.mit.edu	37	11	7982663	7982663	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:7982663G>C	uc001mfv.1	-	2	513	c.496C>G	c.(496-498)CCA>GCA	p.P166A		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	166							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)														---	---	---	---
ABCC8	6833	broad.mit.edu	37	11	17482133	17482133	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:17482133A>G	uc001mnc.2	-	6	1039	c.913T>C	c.(913-915)TTC>CTC	p.F305L	ABCC8_uc010rcy.1_Missense_Mutation_p.F304L	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	305	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)													---	---	---	---
TSG101	7251	broad.mit.edu	37	11	18531130	18531130	+	Missense_Mutation	SNP	G	A	A	rs140156278		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18531130G>A	uc001mor.2	-	5	566	c.440C>T	c.(439-441)TCG>TTG	p.S147L	TSG101_uc001mos.1_Missense_Mutation_p.S95L|TSG101_uc009yhs.1_RNA	NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	147					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0																		---	---	---	---
TSG101	7251	broad.mit.edu	37	11	18531132	18531132	+	Silent	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18531132A>T	uc001mor.2	-	5	564	c.438T>A	c.(436-438)ATT>ATA	p.I146I	TSG101_uc001mos.1_Silent_p.I94I|TSG101_uc009yhs.1_RNA	NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	146					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0																		---	---	---	---
IGSF22	283284	broad.mit.edu	37	11	18731162	18731162	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18731162G>A	uc009yht.2	-	18	2960	c.2770C>T	c.(2770-2772)CGG>TGG	p.R924W	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	823	Fibronectin type-III 2.									ovary(4)|large_intestine(2)|kidney(1)	7																		---	---	---	---
IGSF22	283284	broad.mit.edu	37	11	18736102	18736102	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18736102C>T	uc009yht.2	-	12	1791	c.1601G>A	c.(1600-1602)TGT>TAT	p.C534Y	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	534										ovary(4)|large_intestine(2)|kidney(1)	7																		---	---	---	---
PTPN5	84867	broad.mit.edu	37	11	18763909	18763909	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:18763909C>T	uc001mpd.2	-	7	1056	c.625G>A	c.(625-627)GAC>AAC	p.D209N	PTPN5_uc001mpb.2_Missense_Mutation_p.D177N|PTPN5_uc001mpc.2_Missense_Mutation_p.D209N|PTPN5_uc001mpe.2_Missense_Mutation_p.D177N|PTPN5_uc010rdj.1_Missense_Mutation_p.D153N|PTPN5_uc001mpf.2_Missense_Mutation_p.D185N|PTPN5_uc010rdk.1_Missense_Mutation_p.D154N	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	209						integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2																		---	---	---	---
NAV2	89797	broad.mit.edu	37	11	19955693	19955693	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:19955693A>G	uc010rdm.1	+	8	2333	c.1972A>G	c.(1972-1974)AGC>GGC	p.S658G	NAV2_uc001mpp.2_Missense_Mutation_p.S571G|NAV2_uc001mpr.3_Missense_Mutation_p.S635G	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	658						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6																		---	---	---	---
DBX1	120237	broad.mit.edu	37	11	20177913	20177913	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:20177913C>T	uc001mpw.1	-	4	996	c.996G>A	c.(994-996)GCG>GCA	p.A332A		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	293					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
ANO3	63982	broad.mit.edu	37	11	26558959	26558959	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:26558959G>A	uc001mqt.3	+	10	1128	c.983G>A	c.(982-984)CGT>CAT	p.R328H	ANO3_uc010rdr.1_Missense_Mutation_p.R312H|ANO3_uc010rds.1_Missense_Mutation_p.R167H|ANO3_uc010rdt.1_Missense_Mutation_p.R182H	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	328	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity	p.R328H(1)		ovary(2)|central_nervous_system(1)|pancreas(1)	4																		---	---	---	---
Unknown	0	broad.mit.edu	37	11	30921956	30921956	+	RNA	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30921956G>T	uc001mss.1	-	11		c.1694C>A			uc009yjk.1_Missense_Mutation_p.L979I|uc009yjj.1_RNA					Homo sapiens mRNA for KIAA1493 protein, partial cds.																														---	---	---	---
Unknown	0	broad.mit.edu	37	11	30946902	30946902	+	RNA	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:30946902T>C	uc001mss.1	-	1		c.54A>G			uc009yjk.1_Missense_Mutation_p.K432R					Homo sapiens mRNA for KIAA1493 protein, partial cds.																														---	---	---	---
ACCS	84680	broad.mit.edu	37	11	44097067	44097067	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:44097067C>T	uc009yks.1	+						EXT2_uc010rfo.1_5'Flank|ACCS_uc010rfm.1_Intron|ACCS_uc010rfn.1_Intron|ACCS_uc001mxx.2_Intron	NM_001127219	NP_001120691			1-aminocyclopropane-1-carboxylate synthase								1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4																		---	---	---	---
SYT13	57586	broad.mit.edu	37	11	45277422	45277422	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:45277422C>T	uc001myq.2	-	2	330	c.204G>A	c.(202-204)ACG>ACA	p.T68T	SYT13_uc009yku.1_5'UTR	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	68	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1																		---	---	---	---
HARBI1	283254	broad.mit.edu	37	11	46625304	46625304	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:46625304C>A	uc001ncy.2	-	3	1074	c.826G>T	c.(826-828)GGA>TGA	p.G276*		NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	276						cytoplasm|nucleus	metal ion binding|nuclease activity				0																		---	---	---	---
CTNND1	1500	broad.mit.edu	37	11	57583474	57583474	+	Splice_Site	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57583474G>A	uc001nmc.3	+	20	3466	c.2895_splice	c.e20+1	p.M965_splice	CTNND1_uc001nlh.1_Intron|CTNND1_uc001nlu.3_Intron|CTNND1_uc001nlt.3_Intron|CTNND1_uc001nls.3_Splice_Site_p.M837_splice|CTNND1_uc001nlw.3_Intron|CTNND1_uc001nmf.3_Intron|CTNND1_uc001nmd.3_Splice_Site_p.M911_splice|CTNND1_uc001nlk.3_Intron|CTNND1_uc001nme.3_Splice_Site_p.M959_splice|CTNND1_uc001nll.3_Intron|CTNND1_uc001nmg.3_Intron|CTNND1_uc001nlj.3_Splice_Site_p.M905_splice|CTNND1_uc001nlr.3_Intron|CTNND1_uc001nlp.3_Splice_Site_p.M884_splice|CTNND1_uc001nlx.3_Splice_Site_p.M642_splice|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Intron|CTNND1_uc001nly.3_Splice_Site_p.M636_splice|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Splice_Site_p.M615_splice|CTNND1_uc001nmi.3_Splice_Site_p.M864_splice|CTNND1_uc001nmh.3_Intron|CTNND1_uc001nlq.3_Intron|CTNND1_uc001nln.3_Intron|CTNND1_uc001nli.3_Splice_Site_p.M938_splice|CTNND1_uc001nlo.3_Splice_Site_p.M858_splice|CTNND1_uc001nlv.3_Intron	NM_001085458	NP_001078927			catenin, delta 1 isoform 1ABC						adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)																---	---	---	---
OR10Q1	219960	broad.mit.edu	37	11	57995911	57995911	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:57995911G>A	uc010rkd.1	-	1	437	c.437C>T	c.(436-438)ACG>ATG	p.T146M		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)																---	---	---	---
CCDC86	79080	broad.mit.edu	37	11	60610001	60610001	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60610001C>A	uc001nqa.2	+	1	573	c.404C>A	c.(403-405)GCC>GAC	p.A135D	CCDC86_uc001nqb.2_Intron	NM_024098	NP_077003	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	135	Pro-rich.				interspecies interaction between organisms	nucleus					0																		---	---	---	---
CD6	923	broad.mit.edu	37	11	60785823	60785823	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:60785823C>T	uc001nqq.2	+	12	2123	c.1900C>T	c.(1900-1902)CCA>TCA	p.P634S	CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_Intron|CD6_uc001nqt.2_Intron	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	634	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1																		---	---	---	---
ROM1	6094	broad.mit.edu	37	11	62381723	62381723	+	Intron	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62381723T>C	uc001ntv.2	+						EML3_uc001ntr.1_5'Flank|EML3_uc001nts.1_5'Flank|EML3_uc001ntt.1_5'Flank|EML3_uc001ntu.1_5'Flank|EML3_uc010rly.1_5'Flank|EML3_uc009yny.1_5'Flank	NM_000327	NP_000318			retinal outer segment membrane protein 1						cell adhesion|visual perception	integral to plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
LRRN4CL	221091	broad.mit.edu	37	11	62455516	62455516	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62455516G>A	uc001nun.2	-	2	772	c.465C>T	c.(463-465)GCC>GCT	p.A155A		NM_203422	NP_981967	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like precursor	155	Fibronectin type-III.|Extracellular (Potential).					integral to membrane					0																		---	---	---	---
BSCL2	26580	broad.mit.edu	37	11	62458808	62458808	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:62458808T>C	uc001nuo.1	-	7	1181	c.757A>G	c.(757-759)AGC>GGC	p.S253G	LRRN4CL_uc001nun.2_5'Flank|BSCL2_uc009yoc.1_Intron|BSCL2_uc001nup.2_Missense_Mutation_p.S253G|BSCL2_uc001nuq.1_Missense_Mutation_p.S253G|BSCL2_uc001nur.3_Missense_Mutation_p.S317G|BSCL2_uc009yod.2_Missense_Mutation_p.S317G|BSCL2_uc001nut.3_Missense_Mutation_p.S317G|HNRNPUL2_uc001nuu.1_RNA	NM_032667	NP_116056	Q96G97	BSCL2_HUMAN	seipin isoform 2	253	Helical; (Potential).				cell death	integral to endoplasmic reticulum membrane					0																		---	---	---	---
SLC22A12	116085	broad.mit.edu	37	11	64359056	64359056	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64359056G>A	uc001oam.1	+	1	775	c.28G>A	c.(28-30)GTG>ATG	p.V10M	SLC22A12_uc009ypr.1_Missense_Mutation_p.V10M|SLC22A12_uc001oal.1_Intron|SLC22A12_uc009yps.1_Missense_Mutation_p.V10M|SLC22A12_uc001oan.1_Missense_Mutation_p.V10M|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	10	Helical; (Potential).				cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64397948	64397948	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64397948A>G	uc001oap.2	-	4	1056	c.545T>C	c.(544-546)GTG>GCG	p.V182A	NRXN2_uc001oar.2_Missense_Mutation_p.V1228A|NRXN2_uc001oas.2_Missense_Mutation_p.V1188A|NRXN2_uc001oaq.2_Missense_Mutation_p.V895A	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	182	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
NRXN2	9379	broad.mit.edu	37	11	64410059	64410059	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64410059C>T	uc001oap.2	-	2	728	c.217G>A	c.(217-219)GTG>ATG	p.V73M	NRXN2_uc001oar.2_Intron|NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_Intron	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	73	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10																		---	---	---	---
RASGRP2	10235	broad.mit.edu	37	11	64509498	64509498	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64509498C>T	uc009ypu.2	-	3	387	c.160G>A	c.(160-162)GCC>ACC	p.A54T	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Missense_Mutation_p.A54T|RASGRP2_uc009ypw.2_Missense_Mutation_p.A54T|RASGRP2_uc001oaw.1_3'UTR	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	54	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0																		---	---	---	---
CAPN1	823	broad.mit.edu	37	11	64972271	64972271	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:64972271G>A	uc009yqd.1	+	11	1394	c.1283G>A	c.(1282-1284)CGT>CAT	p.R428H	CAPN1_uc001odf.1_Missense_Mutation_p.R428H|CAPN1_uc001odg.1_Missense_Mutation_p.R428H|CAPN1_uc010roa.1_Missense_Mutation_p.R169H	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	428	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)												OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DKFZp761E198	91056	broad.mit.edu	37	11	65546371	65546371	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:65546371C>T	uc001ofo.3	-	1	1452	c.1422G>A	c.(1420-1422)CCG>CCA	p.P474P		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	474							protein binding				0				READ - Rectum adenocarcinoma(159;0.167)														---	---	---	---
ZDHHC24	254359	broad.mit.edu	37	11	66313303	66313303	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66313303C>T	uc001oin.1	-	1	369	c.172G>A	c.(172-174)GCC>ACC	p.A58T	ACTN3_uc010rpi.1_5'Flank|ACTN3_uc001oio.1_5'Flank|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_Missense_Mutation_p.A58T	NM_207340	NP_997223	Q6UX98	ZDH24_HUMAN	zinc finger, DHHC-type containing 24	58	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding				0																		---	---	---	---
RBM14	10432	broad.mit.edu	37	11	66391987	66391987	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:66391987C>T	uc001oit.2	+	2	779	c.640C>T	c.(640-642)CGC>TGC	p.R214C	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	214					DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3																		---	---	---	---
KDM2A	22992	broad.mit.edu	37	11	67021898	67021898	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67021898C>T	uc001ojw.2	+						KDM2A_uc001ojx.2_Intron|KDM2A_uc001ojy.2_Intron|KDM2A_uc001ojz.1_Silent_p.L564L|KDM2A_uc001oka.2_Intron	NM_012308	NP_036440			F-box and leucine-rich repeat protein 11						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			ovary(4)|lung(3)|breast(1)|skin(1)	9																		---	---	---	---
CARNS1	57571	broad.mit.edu	37	11	67192057	67192057	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67192057G>A	uc009yrp.2	+	9	2921	c.2469G>A	c.(2467-2469)CTG>CTA	p.L823L	CARNS1_uc001olc.3_Silent_p.L962L	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	823					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0																		---	---	---	---
PITPNM1	9600	broad.mit.edu	37	11	67260427	67260427	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67260427C>T	uc001olx.2	-	22	3638	c.3449G>A	c.(3448-3450)CGG>CAG	p.R1150Q	PITPNM1_uc001olw.2_Missense_Mutation_p.R432Q|PITPNM1_uc001oly.2_Missense_Mutation_p.R1150Q|PITPNM1_uc001olz.2_Missense_Mutation_p.R1149Q	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	1150					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3																		---	---	---	---
PITPNM1	9600	broad.mit.edu	37	11	67260877	67260877	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67260877G>A	uc001olx.2	-						PITPNM1_uc001olw.2_Intron|PITPNM1_uc001oly.2_Intron|PITPNM1_uc001olz.2_Intron	NM_004910	NP_004901			phosphatidylinositol transfer protein,						brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3																		---	---	---	---
SUV420H1	51111	broad.mit.edu	37	11	67925165	67925165	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:67925165A>C	uc001onm.1	-	11	2904	c.2648T>G	c.(2647-2649)CTT>CGT	p.L883R	SUV420H1_uc009yse.1_Missense_Mutation_p.L469R|SUV420H1_uc001onn.1_Missense_Mutation_p.L711R|SUV420H1_uc009ysf.2_Missense_Mutation_p.L643R	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	883					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3																		---	---	---	---
MRGPRD	116512	broad.mit.edu	37	11	68748126	68748126	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:68748126T>C	uc010rqf.1	-	1	330	c.330A>G	c.(328-330)ACA>ACG	p.T110T		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	110	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)															---	---	---	---
MYEOV	26579	broad.mit.edu	37	11	69063147	69063147	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69063147G>A	uc001oov.2	+	3	680	c.230G>A	c.(229-231)CGG>CAG	p.R77Q	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.R77Q|MYEOV_uc001oow.2_Missense_Mutation_p.R19Q	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	77											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)														---	---	---	---
CCND1	595	broad.mit.edu	37	11	69456219	69456219	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:69456219A>G	uc001opa.2	+	1	347	c.138A>G	c.(136-138)AAA>AAG	p.K46K		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	46	Cyclin N-terminal.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)			T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			---	---	---	---
PPFIA1	8500	broad.mit.edu	37	11	70172691	70172691	+	Intron	SNP	T	C	C	rs58447267		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:70172691T>C	uc001opo.2	+						PPFIA1_uc001opn.1_Intron|PPFIA1_uc001opp.2_Intron|PPFIA1_uc001opq.1_Intron	NM_003626	NP_003617			PTPRF interacting protein alpha 1 isoform b						cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)															---	---	---	---
NUMA1	4926	broad.mit.edu	37	11	71726294	71726294	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71726294C>T	uc001orl.1	-	15	2427	c.2255G>A	c.(2254-2256)CGG>CAG	p.R752Q	NUMA1_uc009ysw.1_Missense_Mutation_p.R315Q|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Missense_Mutation_p.R752Q|NUMA1_uc001orn.2_Missense_Mutation_p.R315Q|NUMA1_uc009ysx.1_Missense_Mutation_p.R752Q|NUMA1_uc001oro.1_Missense_Mutation_p.R752Q	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	752	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8								T	RARA	APL								---	---	---	---
INPPL1	3636	broad.mit.edu	37	11	71948327	71948327	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:71948327C>T	uc001osf.2	+	26	3186	c.3039C>T	c.(3037-3039)ACC>ACT	p.T1013T	INPPL1_uc001osg.2_Silent_p.T771T	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1013	Pro-rich.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4																		---	---	---	---
PLEKHB1	58473	broad.mit.edu	37	11	73364059	73364059	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73364059G>A	uc001oua.2	+	5	821	c.390G>A	c.(388-390)CCG>CCA	p.P130P	PLEKHB1_uc001oub.2_Silent_p.P130P|PLEKHB1_uc010rrh.1_Silent_p.P111P|PLEKHB1_uc001ouc.2_Silent_p.P111P|PLEKHB1_uc001oud.2_Silent_p.P111P|PLEKHB1_uc009ytq.2_Silent_p.P111P	NM_021200	NP_067023	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B	130					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			ovary(1)|lung(1)	2																		---	---	---	---
C2CD3	26005	broad.mit.edu	37	11	73803641	73803641	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:73803641C>T	uc001ouu.2	-							NM_015531	NP_056346			C2 calcium-dependent domain containing 3							centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)																	---	---	---	---
MOGAT2	80168	broad.mit.edu	37	11	75438572	75438572	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75438572G>A	uc010rru.1	+	3	363	c.363G>A	c.(361-363)CTG>CTA	p.L121L	MOGAT2_uc001oww.1_Silent_p.L121L|MOGAT2_uc010rrv.1_Silent_p.L39L	NM_025098	NP_079374	Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	121	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			ovary(2)	2	Ovarian(111;0.103)																	---	---	---	---
WNT11	7481	broad.mit.edu	37	11	75902892	75902892	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:75902892G>A	uc001oxe.2	-	4	729	c.606C>T	c.(604-606)CGC>CGT	p.R202R	WNT11_uc001oxf.1_Silent_p.R202R	NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	202					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2																		---	---	---	---
OMP	4975	broad.mit.edu	37	11	76814001	76814001	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:76814001G>A	uc010rsk.1	+	1	116	c.116G>A	c.(115-117)CGC>CAC	p.R39H	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	39					sensory perception of smell|synaptic transmission						0																		---	---	---	---
INTS4	92105	broad.mit.edu	37	11	77639378	77639378	+	Intron	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:77639378A>G	uc001oys.2	-						INTS4_uc001oyt.2_Intron|INTS4_uc001oyu.1_Intron	NM_033547	NP_291025			integrator complex subunit 4						snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)															---	---	---	---
ODZ4	26011	broad.mit.edu	37	11	78412977	78412977	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:78412977G>A	uc001ozl.3	-	28	5144	c.4681C>T	c.(4681-4683)CGG>TGG	p.R1561W	ODZ4_uc009yvb.1_Missense_Mutation_p.R145W	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1561	NHL 5.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4																		---	---	---	---
RAB30	27314	broad.mit.edu	37	11	82693314	82693314	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:82693314G>A	uc001ozu.2	-	6	766	c.505C>T	c.(505-507)CGA>TGA	p.R169*	RAB30_uc009yve.2_Nonsense_Mutation_p.R167*|RAB30_uc010rst.1_Nonsense_Mutation_p.R167*|RAB30_uc001ozv.2_3'UTR	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	169					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0																		---	---	---	---
DLG2	1740	broad.mit.edu	37	11	83544674	83544674	+	Nonsense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:83544674C>A	uc001paj.2	-	12	1693	c.1390G>T	c.(1390-1392)GGA>TGA	p.G464*	DLG2_uc001pai.2_Nonsense_Mutation_p.G361*|DLG2_uc010rsy.1_Nonsense_Mutation_p.G431*|DLG2_uc010rsz.1_Nonsense_Mutation_p.G464*|DLG2_uc010rta.1_Nonsense_Mutation_p.G464*|DLG2_uc001pak.2_Nonsense_Mutation_p.G569*|DLG2_uc010rtb.1_Nonsense_Mutation_p.G431*|DLG2_uc001pal.1_Nonsense_Mutation_p.G464*|DLG2_uc001pam.1_Nonsense_Mutation_p.G503*	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	464	PDZ 3.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)																---	---	---	---
SYTL2	54843	broad.mit.edu	37	11	85436343	85436343	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:85436343G>A	uc010rth.1	-						SYTL2_uc010rtg.1_Intron|SYTL2_uc010rti.1_Intron|SYTL2_uc010rtj.1_Intron|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Missense_Mutation_p.S386L|SYTL2_uc001pbb.2_Missense_Mutation_p.S386L|SYTL2_uc001pbc.2_Missense_Mutation_p.S386L|SYTL2_uc010rtf.1_Intron	NM_001162951	NP_001156423			synaptotagmin-like 2 isoform g						intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)														---	---	---	---
EED	8726	broad.mit.edu	37	11	85979585	85979585	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:85979585C>T	uc001pbp.2	+	9	1405	c.948C>T	c.(946-948)GGC>GGT	p.G316G	EED_uc010rtm.1_Silent_p.G316G|EED_uc001pbq.2_Silent_p.G316G|EED_uc001pbr.2_Silent_p.G316G|EED_uc001pbs.2_Intron|EED_uc010rtn.1_Intron	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	316	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.|WD 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)																---	---	---	---
PRSS23	11098	broad.mit.edu	37	11	86519672	86519672	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:86519672G>A	uc001pcb.2	+	2	1203	c.987G>A	c.(985-987)CAG>CAA	p.Q329Q	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Silent_p.Q297Q	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	329					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92532189	92532189	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92532189G>A	uc001pdj.3	+	9	6027	c.6010G>A	c.(6010-6012)GTC>ATC	p.V2004I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2004	Extracellular (Potential).|Cadherin 18.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92599971	92599971	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92599971C>T	uc001pdj.3	+	21	11740	c.11723C>T	c.(11722-11724)TCG>TTG	p.S3908L	FAT3_uc001pdi.3_Missense_Mutation_p.S348L	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3908	Laminin G-like.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
FAT3	120114	broad.mit.edu	37	11	92600059	92600059	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92600059C>T	uc001pdj.3	+	21	11828	c.11811C>T	c.(11809-11811)TAC>TAT	p.Y3937Y	FAT3_uc001pdi.3_Silent_p.Y377Y	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3937	Laminin G-like.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)													TCGA Ovarian(4;0.039)			---	---	---	---
MTNR1B	4544	broad.mit.edu	37	11	92714707	92714707	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:92714707G>A	uc001pdk.1	+	2	421	c.318G>A	c.(316-318)TGG>TGA	p.W106*		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	106	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)													---	---	---	---
MED17	9440	broad.mit.edu	37	11	93530716	93530716	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:93530716T>C	uc001pem.3	+	8	1434	c.1159T>C	c.(1159-1161)TTG>CTG	p.L387L		NM_004268	NP_004259	Q9NVC6	MED17_HUMAN	mediator complex subunit 17	387					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
AMOTL1	154810	broad.mit.edu	37	11	94554713	94554713	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:94554713C>T	uc001pfb.2	+	4	1309	c.1139C>T	c.(1138-1140)CCG>CTG	p.P380L	AMOTL1_uc001pfc.2_Missense_Mutation_p.P330L	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	380						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)																---	---	---	---
MTMR2	8898	broad.mit.edu	37	11	95580917	95580917	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:95580917C>A	uc001pfu.2	-	10	1393	c.1140G>T	c.(1138-1140)TTG>TTT	p.L380F	MTMR2_uc001pfv.2_Missense_Mutation_p.L308F|MTMR2_uc001pfs.2_Missense_Mutation_p.L308F|MTMR2_uc001pft.2_Missense_Mutation_p.L308F|MTMR2_uc010ruj.1_Missense_Mutation_p.L363F	NM_016156	NP_057240	Q13614	MTMR2_HUMAN	myotubularin-related protein 2 isoform 1	380	Myotubularin phosphatase.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)																---	---	---	---
CWF19L2	143884	broad.mit.edu	37	11	107224389	107224389	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:107224389C>T	uc010rvp.1	-	13	1976	c.1946G>A	c.(1945-1947)CGT>CAT	p.R649H	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	649	Potential.						catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)														---	---	---	---
ACAT1	38	broad.mit.edu	37	11	108017090	108017090	+	Intron	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:108017090G>T	uc001pjy.2	+							NM_000019	NP_000010			acetyl-Coenzyme A acetyltransferase 1 precursor						acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)													---	---	---	---
ZC3H12C	85463	broad.mit.edu	37	11	110036179	110036179	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110036179G>A	uc009yxw.2	+	6	2420	c.2369G>A	c.(2368-2370)CGG>CAG	p.R790Q	ZC3H12C_uc010rwc.1_Missense_Mutation_p.R791Q|ZC3H12C_uc010rwd.1_Missense_Mutation_p.R791Q|ZC3H12C_uc001pkr.3_Missense_Mutation_p.R759Q	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	790							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)														---	---	---	---
Unknown	0	broad.mit.edu	37	11	110697306	110697306	+	IGR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:110697306C>T								ARHGAP20 (113394 upstream) : C11orf53 (429401 downstream)																																			---	---	---	---
SIK2	23235	broad.mit.edu	37	11	111594685	111594685	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111594685A>G	uc001plt.2	+	15	2731	c.2613A>G	c.(2611-2613)GGA>GGG	p.G871G		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	871					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3																		---	---	---	---
DIXDC1	85458	broad.mit.edu	37	11	111855970	111855970	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111855970T>C	uc001pml.2	+	9	1230	c.933T>C	c.(931-933)AAT>AAC	p.N311N	DIXDC1_uc001pmm.2_Silent_p.N100N|DIXDC1_uc001pmn.2_Silent_p.N17N	NM_001037954	NP_001033043	Q155Q3	DIXC1_HUMAN	DIX domain containing 1 isoform a	311	Potential.				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytosol|focal adhesion	actin binding|gamma-tubulin binding|signal transducer activity			ovary(1)	1		all_cancers(61;7.58e-15)|all_epithelial(67;5.42e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;2.99e-07)|BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|all cancers(92;6.25e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0548)														---	---	---	---
DLAT	1737	broad.mit.edu	37	11	111904183	111904183	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:111904183A>G	uc001pmo.2	+	5	1375	c.716A>G	c.(715-717)GAA>GGA	p.E239G	DLAT_uc009yyk.1_Intron|DLAT_uc010rwr.1_Intron	NM_001931	NP_001922	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase precursor	239	Lipoyl-binding 2.				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding				0		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)													---	---	---	---
SIDT2	51092	broad.mit.edu	37	11	117059506	117059506	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:117059506C>T	uc001pqh.1	+	13	1283	c.1242C>T	c.(1240-1242)ACC>ACT	p.T414T	SIDT2_uc010rxe.1_Silent_p.T414T|SIDT2_uc001pqg.2_Silent_p.T435T|SIDT2_uc001pqi.1_Silent_p.T411T	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	414	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)														---	---	---	---
CD3E	916	broad.mit.edu	37	11	118183329	118183329	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118183329C>T	uc001psq.3	+						CD3E_uc010rya.1_Intron	NM_000733	NP_000724			CD3E antigen, epsilon polypeptide precursor						G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)													---	---	---	---
MLL	4297	broad.mit.edu	37	11	118344530	118344530	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118344530C>T	uc001pta.2	+	3	2679	c.2656C>T	c.(2656-2658)CGG>TGG	p.R886W	MLL_uc001ptb.2_Missense_Mutation_p.R886W|MLL_uc001psz.1_Missense_Mutation_p.R919W|MLL_uc001ptd.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	886					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)				T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								---	---	---	---
PHLDB1	23187	broad.mit.edu	37	11	118527419	118527419	+	Silent	SNP	C	T	T	rs148039830		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:118527419C>T	uc001ptr.1	+	24	4373	c.4020C>T	c.(4018-4020)TGC>TGT	p.C1340C	PHLDB1_uc001pts.2_Silent_p.C1340C|PHLDB1_uc001ptt.2_Silent_p.C1282C|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Silent_p.C1144C|PHLDB1_uc001ptw.1_Silent_p.C684C|PHLDB1_uc009zai.1_Silent_p.C365C|PHLDB1_uc001ptx.1_Silent_p.C365C	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1340	PH.										0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)														---	---	---	---
ABCG4	64137	broad.mit.edu	37	11	119031362	119031362	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119031362G>A	uc001pvs.2	+	14	2047	c.1711G>A	c.(1711-1713)GTC>ATC	p.V571I	ABCG4_uc009zar.2_Missense_Mutation_p.V571I	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	571	Extracellular (Potential).|ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)														---	---	---	---
RNF26	79102	broad.mit.edu	37	11	119207088	119207088	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:119207088C>T	uc001pwh.2	+	1	1852	c.1256C>T	c.(1255-1257)CCG>CTG	p.P419L		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	419	RING-type.						zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)														---	---	---	---
TRIM29	23650	broad.mit.edu	37	11	120008518	120008518	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120008518C>T	uc001pwz.2	-	1	346	c.222G>A	c.(220-222)GAG>GAA	p.E74E	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	74					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)														---	---	---	---
GRIK4	2900	broad.mit.edu	37	11	120690618	120690618	+	Missense_Mutation	SNP	C	T	T	rs41297895	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120690618C>T	uc001pxn.2	+	6	787	c.500C>T	c.(499-501)GCC>GTC	p.A167V	GRIK4_uc009zav.1_Missense_Mutation_p.A167V|GRIK4_uc009zaw.1_Missense_Mutation_p.A167V|GRIK4_uc009zax.1_Missense_Mutation_p.A167V	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	167	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)													---	---	---	---
TECTA	7007	broad.mit.edu	37	11	120998774	120998774	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:120998774C>T	uc010rzo.1	+	8	2088	c.2088C>T	c.(2086-2088)TGC>TGT	p.C696C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	696					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)														---	---	---	---
SORL1	6653	broad.mit.edu	37	11	121393406	121393406	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:121393406G>A	uc001pxx.2	+	10	1596	c.1516G>A	c.(1516-1518)GCC>ACC	p.A506T		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	506	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)														---	---	---	---
OR10G7	390265	broad.mit.edu	37	11	123909320	123909320	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:123909320C>A	uc001pzq.1	-	1	389	c.389G>T	c.(388-390)AGG>ATG	p.R130M		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)														---	---	---	---
KIRREL3	84623	broad.mit.edu	37	11	126333072	126333072	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:126333072G>A	uc001qea.2	-	6	1083	c.722C>T	c.(721-723)TCG>TTG	p.S241L	KIRREL3_uc001qeb.2_Missense_Mutation_p.S241L|KIRREL3_uc001qec.1_Missense_Mutation_p.S241L	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	241	Ig-like C2-type 2.|Extracellular (Potential).				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)														---	---	---	---
APLP2	334	broad.mit.edu	37	11	129980502	129980502	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:129980502C>T	uc010sby.1	+	3	506	c.349C>T	c.(349-351)CGG>TGG	p.R117W	APLP2_uc001qfp.2_Missense_Mutation_p.R117W|APLP2_uc001qfq.2_Missense_Mutation_p.R117W|APLP2_uc010sbz.1_Intron|APLP2_uc001qfr.2_Intron|APLP2_uc001qfs.2_Missense_Mutation_p.R117W|APLP2_uc001qfv.2_Missense_Mutation_p.R64W	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	117	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)														---	---	---	---
GLB1L2	89944	broad.mit.edu	37	11	134234257	134234257	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134234257C>T	uc001qhp.2	+	8	957	c.769C>T	c.(769-771)CTG>TTG	p.L257L	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	257					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)														---	---	---	---
B3GAT1	27087	broad.mit.edu	37	11	134257541	134257541	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr11:134257541G>A	uc001qhq.2	-	3	274	c.13C>T	c.(13-15)CGG>TGG	p.R5W	B3GAT1_uc001qhr.2_Missense_Mutation_p.R5W|B3GAT1_uc010scv.1_Missense_Mutation_p.R18W	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	5	Cytoplasmic (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)														---	---	---	---
WNT5B	81029	broad.mit.edu	37	12	1748958	1748958	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1748958C>T	uc009zdq.2	+	4	679	c.437C>T	c.(436-438)ACG>ATG	p.T146M	WNT5B_uc001qjj.2_Missense_Mutation_p.T146M|WNT5B_uc001qjk.2_Missense_Mutation_p.T146M|WNT5B_uc001qjl.2_Missense_Mutation_p.T146M	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	146					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)															---	---	---	---
ADIPOR2	79602	broad.mit.edu	37	12	1893046	1893046	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:1893046G>A	uc001qjm.2	+	7	1036	c.839G>A	c.(838-840)GGA>GAA	p.G280E	ADIPOR2_uc001qjn.2_Missense_Mutation_p.G280E	NM_024551	NP_078827	Q86V24	ADR2_HUMAN	adiponectin receptor 2	280	Helical; Name=5; (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity				0	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)															---	---	---	---
FGF23	8074	broad.mit.edu	37	12	4479543	4479543	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4479543G>A	uc001qmq.1	-	3	868	c.722C>T	c.(721-723)CCG>CTG	p.P241L		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	241					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)															---	---	---	---
RAD51AP1	10635	broad.mit.edu	37	12	4662161	4662161	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:4662161A>G	uc001qmw.2	+	8	776	c.620A>G	c.(619-621)GAG>GGG	p.E207G	RAD51AP1_uc001qmu.2_Missense_Mutation_p.E190G|RAD51AP1_uc001qmv.2_Missense_Mutation_p.E153G|RAD51AP1_uc010sep.1_Missense_Mutation_p.E72G|RAD51AP1_uc010seq.1_Missense_Mutation_p.E72G|RAD51AP1_uc009zeg.2_RNA	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	RAD51 associated protein 1 isoform a	207					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|protein binding|RNA binding|single-stranded DNA binding				0			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)															---	---	---	---
ZNF384	171017	broad.mit.edu	37	12	6777207	6777207	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:6777207T>C	uc010sfh.1	-	11	1615	c.1407A>G	c.(1405-1407)GCA>GCG	p.A469A	ZNF384_uc001qpz.2_Silent_p.A408A|ZNF384_uc001qqa.2_Silent_p.A408A|ZNF384_uc001qqb.2_Silent_p.A392A|ZNF384_uc001qqc.2_Silent_p.A408A|ZNF384_uc001qqd.2_Silent_p.A353A|ZNF384_uc001qqe.2_Silent_p.A392A	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	469	Ala-rich.|Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8								T	EWSR1|TAF15 	ALL								---	---	---	---
LPCAT3	10162	broad.mit.edu	37	12	7086569	7086569	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7086569A>G	uc001qsi.2	-	11	1421	c.1307T>C	c.(1306-1308)ATG>ACG	p.M436T	EMG1_uc010sfv.1_Intron|LPCAT3_uc010sfw.1_Missense_Mutation_p.M330T|LPCAT3_uc009zfp.2_RNA	NM_005768	NP_005759	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	436	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			ovary(1)	1																		---	---	---	---
C1R	715	broad.mit.edu	37	12	7242710	7242710	+	Silent	SNP	G	A	A	rs150953301	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:7242710G>A	uc010sfy.1	-	3	425	c.366C>T	c.(364-366)AAC>AAT	p.N122N	C1R_uc010sfz.1_Silent_p.N136N|C1R_uc010sga.1_Silent_p.N88N	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	122	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)													---	---	---	---
A2ML1	144568	broad.mit.edu	37	12	9004599	9004599	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:9004599T>C	uc001quz.3	+	19	2552	c.2454T>C	c.(2452-2454)GAT>GAC	p.D818D	A2ML1_uc001qva.1_Silent_p.D398D|A2ML1_uc010sgm.1_Silent_p.D318D	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	662						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3																		---	---	---	---
CSDA	8531	broad.mit.edu	37	12	10854623	10854623	+	Missense_Mutation	SNP	C	T	T	rs144824557		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:10854623C>T	uc001qyt.2	-	8	1232	c.989G>A	c.(988-990)CGG>CAG	p.R330Q	CSDA_uc001qyu.2_Missense_Mutation_p.R261Q	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	330					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)																	---	---	---	---
PLEKHA5	54477	broad.mit.edu	37	12	19427533	19427533	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:19427533T>C	uc001reb.2	+	10	997	c.911T>C	c.(910-912)ATC>ACC	p.I304T	PLEKHA5_uc010sie.1_Missense_Mutation_p.I310T|PLEKHA5_uc001rea.2_Missense_Mutation_p.I304T|PLEKHA5_uc009zin.2_Missense_Mutation_p.I62T|PLEKHA5_uc010sif.1_Missense_Mutation_p.I196T|PLEKHA5_uc010sig.1_Missense_Mutation_p.I196T|PLEKHA5_uc010sih.1_Missense_Mutation_p.I196T|PLEKHA5_uc001rec.1_5'UTR	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	304							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)																	---	---	---	---
RECQL	5965	broad.mit.edu	37	12	21644542	21644542	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21644542A>G	uc001rex.2	-	4	473	c.125T>C	c.(124-126)CTG>CCG	p.L42P	RECQL_uc001rey.2_Missense_Mutation_p.L42P	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	42					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2													Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
KCNJ8	3764	broad.mit.edu	37	12	21926431	21926431	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:21926431G>A	uc001rff.2	-	2	458	c.120C>T	c.(118-120)AGC>AGT	p.S40S		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	40	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
ITPR2	3709	broad.mit.edu	37	12	26749969	26749969	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:26749969A>G	uc001rhg.2	-	31	4518	c.4101T>C	c.(4099-4101)GAT>GAC	p.D1367D		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1367	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)																	---	---	---	---
FGFR1OP2	26127	broad.mit.edu	37	12	27113510	27113510	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27113510T>C	uc001rhm.2	+	5	801	c.459T>C	c.(457-459)CTT>CTC	p.L153L	FGFR1OP2_uc001rhl.2_Silent_p.L153L|FGFR1OP2_uc001rhn.2_Intron	NM_015633	NP_056448	Q9NVK5	FGOP2_HUMAN	FGFR1 oncogene partner 2	153						cytoplasm					0	Colorectal(261;0.0847)																	---	---	---	---
PPFIBP1	8496	broad.mit.edu	37	12	27824371	27824371	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:27824371C>G	uc001ric.1	+	14	1582	c.1205C>G	c.(1204-1206)ACT>AGT	p.T402S	PPFIBP1_uc010sjr.1_Missense_Mutation_p.T233S|PPFIBP1_uc001rib.1_Missense_Mutation_p.T385S|PPFIBP1_uc001ria.2_Missense_Mutation_p.T371S|PPFIBP1_uc001rid.1_Missense_Mutation_p.T249S	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	402	Potential.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)																	---	---	---	---
TWF1	5756	broad.mit.edu	37	12	44193205	44193205	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:44193205T>A	uc001rob.2	-	5	609	c.581A>T	c.(580-582)AAT>ATT	p.N194I	TWF1_uc001rnz.2_Missense_Mutation_p.N62I|TWF1_uc001roa.2_Missense_Mutation_p.N194I|TWF1_uc001roc.2_Missense_Mutation_p.N62I	NM_002822	NP_002813	Q12792	TWF1_HUMAN	twinfilin 1	160						actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity			stomach(1)	1	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)														---	---	---	---
ARID2	196528	broad.mit.edu	37	12	46215264	46215264	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:46215264C>T	uc001ros.1	+	6	699	c.699C>T	c.(697-699)TTC>TTT	p.F233F	ARID2_uc001ror.2_Silent_p.F233F	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	233					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)														---	---	---	---
VDR	7421	broad.mit.edu	37	12	48272749	48272749	+	Splice_Site	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48272749A>G	uc001rqm.2	-	4	428	c.146_splice	c.e4+1	p.R49_splice	VDR_uc001rql.2_Splice_Site_p.R99_splice|VDR_uc001rqn.2_Splice_Site_p.R49_splice|VDR_uc010slq.1_5'UTR	NM_001017535	NP_001017535			vitamin D (1,25-dihydroxyvitamin D3) receptor						decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)													---	---	---	---
COL2A1	1280	broad.mit.edu	37	12	48380862	48380862	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:48380862G>A	uc001rqu.2	-	21	1545	c.1364C>T	c.(1363-1365)ACG>ATG	p.T455M	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.T386M	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	455	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)													---	---	---	---
MLL2	8085	broad.mit.edu	37	12	49445674	49445674	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49445674G>A	uc001rta.3	-	10	1792	c.1792C>T	c.(1792-1794)CGT>TGT	p.R598C		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	598	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41								N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			---	---	---	---
KCNH3	23416	broad.mit.edu	37	12	49937815	49937815	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:49937815C>T	uc001ruh.1	+	6	1201	c.941C>T	c.(940-942)GCG>GTG	p.A314V	KCNH3_uc010smj.1_Missense_Mutation_p.A254V	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	314	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0																		---	---	---	---
ACVR1B	91	broad.mit.edu	37	12	52380676	52380676	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:52380676A>G	uc001rzn.2	+	7	1253	c.1211A>G	c.(1210-1212)TAT>TGT	p.Y404C	ACVR1B_uc001rzl.2_Missense_Mutation_p.Y404C|ACVR1B_uc001rzm.2_Missense_Mutation_p.Y404C|ACVR1B_uc010snn.1_Missense_Mutation_p.Y445C	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	404	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)													---	---	---	---
AMHR2	269	broad.mit.edu	37	12	53819659	53819659	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53819659C>T	uc001scx.1	+	6	886	c.808C>T	c.(808-810)CGC>TGC	p.R270C	AMHR2_uc009zmy.1_Missense_Mutation_p.R270C	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	270	Cytoplasmic (Potential).|Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				---	---	---	---
MAP3K12	7786	broad.mit.edu	37	12	53876800	53876800	+	Missense_Mutation	SNP	C	T	T	rs143743852		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:53876800C>T	uc001sdm.1	-	12	1786	c.1688G>A	c.(1687-1689)CGT>CAT	p.R563H	MAP3K12_uc001sdn.1_Missense_Mutation_p.R596H	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	563					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5																		---	---	---	---
OR6C70	390327	broad.mit.edu	37	12	55863642	55863642	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:55863642C>T	uc010spn.1	-	1	281	c.281G>A	c.(280-282)GGT>GAT	p.G94D		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1																		---	---	---	---
BLOC1S1	2647	broad.mit.edu	37	12	56113331	56113331	+	3'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56113331C>T	uc009zny.1	+	3					BLOC1S1_uc001shi.2_Missense_Mutation_p.R106C|BLOC1S1_uc001shj.3_Intron|RDH5_uc010spt.1_5'Flank|RDH5_uc010spu.1_5'Flank|RDH5_uc001shk.2_5'Flank|RDH5_uc001shl.2_5'Flank					RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 1;          Short=BLOC-1 subunit 1; AltName: Full=GCN5-like protein 1; AltName: Full=Protein RT14;						cellular membrane organization|melanosome organization|platelet dense granule organization|post-Golgi vesicle-mediated transport	BLOC-1 complex|lysosomal membrane	protein binding				0																		---	---	---	---
RNF41	10193	broad.mit.edu	37	12	56604256	56604256	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:56604256C>T	uc001skf.1	-	4	556	c.187G>A	c.(187-189)GCC>ACC	p.A63T	RNF41_uc001ske.1_5'UTR|RNF41_uc001skg.1_Missense_Mutation_p.A63T|RNF41_uc010sqg.1_Intron|RNF41_uc010sqh.1_5'UTR|RNF41_uc001skh.2_Missense_Mutation_p.A76T	NM_005785	NP_005776	Q9H4P4	RNF41_HUMAN	ring finger protein 41 isoform 1	63					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1																		---	---	---	---
STAC3	246329	broad.mit.edu	37	12	57637988	57637988	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57637988G>A	uc001snp.2	-	11	1074	c.879C>T	c.(877-879)GTC>GTT	p.V293V	STAC3_uc009zpl.2_Missense_Mutation_p.R11W|STAC3_uc001snq.2_Silent_p.V254V|STAC3_uc010srm.1_Silent_p.V107V	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	293	SH3 1.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3																OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
R3HDM2	22864	broad.mit.edu	37	12	57674184	57674184	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57674184G>A	uc009zpm.1	-	12	1294	c.1259C>T	c.(1258-1260)ACG>ATG	p.T420M	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.T81M|R3HDM2_uc001snr.2_Missense_Mutation_p.T147M|R3HDM2_uc001sns.2_Missense_Mutation_p.T420M|R3HDM2_uc001snt.2_Missense_Mutation_p.T434M|R3HDM2_uc009zpn.1_Missense_Mutation_p.T43M	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	420	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2																		---	---	---	---
GLI1	2735	broad.mit.edu	37	12	57865760	57865760	+	Silent	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:57865760G>C	uc001snx.2	+	12	3315	c.3237G>C	c.(3235-3237)GGG>GGC	p.G1079G	GLI1_uc009zpq.2_Silent_p.G951G	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	1079					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)															---	---	---	---
FAM119B	25895	broad.mit.edu	37	12	58174093	58174093	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:58174093C>T	uc001sqg.2	+	3	470	c.345C>T	c.(343-345)AAC>AAT	p.N115N	FAM119B_uc001sqf.2_3'UTR|FAM119B_uc009zqd.2_RNA|TSFM_uc001sqi.2_5'Flank|TSFM_uc010sse.1_5'Flank|TSFM_uc001sqh.2_5'Flank|TSFM_uc010ssf.1_5'Flank	NM_015433	NP_056248	Q96AZ1	MT21B_HUMAN	hypothetical protein LOC25895 isoform a	115						integral to membrane|intracellular	methyltransferase activity				0	all_cancers(7;9.07e-82)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)																	---	---	---	---
KCNMB4	27345	broad.mit.edu	37	12	70760700	70760700	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70760700C>T	uc001svx.2	+	1	639	c.186C>T	c.(184-186)ATC>ATT	p.I62I		NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	62	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)															---	---	---	---
PTPRB	5787	broad.mit.edu	37	12	70960486	70960486	+	Splice_Site	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:70960486T>C	uc001swb.3	-	13	3011	c.2981_splice	c.e13-1	p.V994_splice	PTPRB_uc010sto.1_Intron|PTPRB_uc010stp.1_Splice_Site_p.V904_splice|PTPRB_uc001swc.3_Splice_Site_p.V1212_splice|PTPRB_uc001swa.3_Splice_Site_p.V1124_splice|PTPRB_uc001swd.3_Splice_Site_p.V1211_splice|PTPRB_uc009zrr.1_Splice_Site_p.V1091_splice	NM_002837	NP_002828			protein tyrosine phosphatase, receptor type, B						angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)															---	---	---	---
ZFC3H1	196441	broad.mit.edu	37	12	72021721	72021721	+	Intron	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:72021721A>T	uc001swo.2	-							NM_144982	NP_659419			proline/serine-rich coiled-coil 2						RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5																		---	---	---	---
CEP290	80184	broad.mit.edu	37	12	88480176	88480176	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:88480176C>T	uc001tar.2	-	33	4638	c.4294G>A	c.(4294-4296)GCA>ACA	p.A1432T	CEP290_uc001taq.2_Missense_Mutation_p.A492T	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1432	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7																		---	---	---	---
EEA1	8411	broad.mit.edu	37	12	93170683	93170683	+	Silent	SNP	G	A	A	rs142495165		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:93170683G>A	uc001tck.2	-	28	4315	c.4050C>T	c.(4048-4050)GCC>GCT	p.A1350A		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	1350					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3																		---	---	---	---
STAB2	55576	broad.mit.edu	37	12	104048390	104048390	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104048390G>T	uc001tjw.2	+	13	1651	c.1465G>T	c.(1465-1467)GGG>TGG	p.G489W		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	489	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14																		---	---	---	---
EID3	493861	broad.mit.edu	37	12	104698248	104698248	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:104698248G>A	uc001tkw.2	+	1	700	c.536G>A	c.(535-537)CGT>CAT	p.R179H	TXNRD1_uc010swk.1_Intron|TXNRD1_uc010swl.1_Intron|TXNRD1_uc010swm.1_Intron|TXNRD1_uc010swn.1_Intron|TXNRD1_uc010swo.1_Intron|TXNRD1_uc010swp.1_Intron|TXNRD1_uc010swq.1_Intron|TXNRD1_uc001tku.2_Intron|TXNRD1_uc001tko.1_Intron|TXNRD1_uc001tkp.1_Intron|TXNRD1_uc001tkv.1_Intron	NM_001008394	NP_001008395	Q8N140	EID3_HUMAN	EP300 interacting inhibitor of differentiation	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus					0																		---	---	---	---
SSH1	54434	broad.mit.edu	37	12	109201572	109201572	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109201572C>T	uc001tnm.2	-	8	655	c.568G>A	c.(568-570)GAA>AAA	p.E190K	SSH1_uc001tnl.2_5'Flank|SSH1_uc010sxg.1_Missense_Mutation_p.E201K|SSH1_uc001tnn.3_Missense_Mutation_p.E190K|SSH1_uc001tno.1_Missense_Mutation_p.E94K	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	190					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4																		---	---	---	---
DAO	1610	broad.mit.edu	37	12	109293174	109293174	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:109293174C>T	uc001tnr.3	+	10	988	c.835C>T	c.(835-837)CGA>TGA	p.R279*	DAO_uc001tnq.3_Nonsense_Mutation_p.R213*|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	279				R -> A (in Ref. 1; CAA31614).	glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2																		---	---	---	---
C12orf51	283450	broad.mit.edu	37	12	112673511	112673511	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:112673511G>T	uc009zwc.2	-	29	4274	c.4256C>A	c.(4255-4257)CCG>CAG	p.P1419Q		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2																		---	---	---	---
RPH3A	22895	broad.mit.edu	37	12	113321126	113321126	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113321126G>A	uc010syl.1	+	16	1717	c.1355G>A	c.(1354-1356)CGG>CAG	p.R452Q	RPH3A_uc001ttz.2_Missense_Mutation_p.R452Q|RPH3A_uc001tty.2_Missense_Mutation_p.R448Q|RPH3A_uc009zwe.1_Missense_Mutation_p.R448Q|RPH3A_uc010sym.1_Missense_Mutation_p.R403Q|RPH3A_uc001tua.2_Missense_Mutation_p.R212Q	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	452	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding	p.R448Q(1)		ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)														---	---	---	---
OAS3	4940	broad.mit.edu	37	12	113405771	113405771	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:113405771C>A	uc001tug.2	+	14	2983	c.2896C>A	c.(2896-2898)CTA>ATA	p.L966I		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	966	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1																		---	---	---	---
WSB2	55884	broad.mit.edu	37	12	118480690	118480690	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:118480690G>A	uc001twr.2	-	4	613	c.515C>T	c.(514-516)GCG>GTG	p.A172V	WSB2_uc010sza.1_5'UTR|WSB2_uc010szb.1_Intron|WSB2_uc009zws.1_Missense_Mutation_p.A172V	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	172	WD 2.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
CIT	11113	broad.mit.edu	37	12	120150099	120150099	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:120150099C>T	uc001txi.1	-	36	4665	c.4612G>A	c.(4612-4614)GGG>AGG	p.G1538R	CIT_uc001txh.1_Missense_Mutation_p.G1057R|CIT_uc001txj.1_Missense_Mutation_p.G1580R	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	1538	PH.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)														---	---	---	---
RNF10	9921	broad.mit.edu	37	12	121013442	121013442	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:121013442G>T	uc001typ.3	+	15	2634	c.2151G>T	c.(2149-2151)AGG>AGT	p.R717S	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.R628S	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	717					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)																	---	---	---	---
CLIP1	6249	broad.mit.edu	37	12	122757436	122757436	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:122757436C>T	uc001ucg.1	-	25	4409	c.4303G>A	c.(4303-4305)GAC>AAC	p.D1435N	CLIP1_uc001uch.1_Missense_Mutation_p.D1424N|CLIP1_uc001uci.1_Missense_Mutation_p.D1389N|CLIP1_uc001ucf.1_Missense_Mutation_p.D94N	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1435					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)														---	---	---	---
DNAH10	196385	broad.mit.edu	37	12	124403311	124403311	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:124403311C>G	uc001uft.3	+	64	10992	c.10967C>G	c.(10966-10968)GCC>GGC	p.A3656G		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3656					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)														---	---	---	---
GOLGA3	2802	broad.mit.edu	37	12	133384552	133384552	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr12:133384552G>A	uc001ukz.1	-	5	1662	c.1103C>T	c.(1102-1104)GCA>GTA	p.A368V	GOLGA3_uc001ula.1_Missense_Mutation_p.A368V|GOLGA3_uc001ulb.2_Missense_Mutation_p.A368V	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	368					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23910913	23910913	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23910913C>T	uc001uon.2	-	10	7691	c.7102G>A	c.(7102-7104)GCA>ACA	p.A2368T	SACS_uc001uoo.2_Missense_Mutation_p.A2221T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2368					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
SACS	26278	broad.mit.edu	37	13	23911667	23911667	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:23911667G>A	uc001uon.2	-	10	6937	c.6348C>T	c.(6346-6348)CCC>CCT	p.P2116P	SACS_uc001uoo.2_Silent_p.P1969P|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	2116					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)														---	---	---	---
RNF17	56163	broad.mit.edu	37	13	25374553	25374553	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:25374553G>A	uc001upr.2	+	13	1680	c.1639G>A	c.(1639-1641)GCA>ACA	p.A547T	RNF17_uc010tdd.1_Missense_Mutation_p.A406T|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.A547T|RNF17_uc001ups.2_Missense_Mutation_p.A486T	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	547					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)														---	---	---	---
WASF3	10810	broad.mit.edu	37	13	27254312	27254312	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:27254312C>T	uc001uqv.2	+						WASF3_uc001uqw.2_Silent_p.S227S	NM_006646	NP_006637			WAS protein family, member 3						actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)														---	---	---	---
FAM48A	55578	broad.mit.edu	37	13	37598274	37598274	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:37598274G>A	uc001uwg.2	-	19	1737	c.1489C>T	c.(1489-1491)CCT>TCT	p.P497S	FAM48A_uc010abt.2_Missense_Mutation_p.P498S|FAM48A_uc001uwh.2_Missense_Mutation_p.P498S|FAM48A_uc001uwi.2_Missense_Mutation_p.P497S|FAM48A_uc001uwj.2_Missense_Mutation_p.P498S|FAM48A_uc001uwk.2_Missense_Mutation_p.P497S|FAM48A_uc010tes.1_Missense_Mutation_p.P461S|FAM48A_uc001uwl.1_Missense_Mutation_p.P497S|FAM48A_uc001uwd.2_5'Flank|FAM48A_uc001uwe.2_5'UTR|FAM48A_uc001uwf.2_Missense_Mutation_p.P75S	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	497					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)														---	---	---	---
C13orf18	80183	broad.mit.edu	37	13	46933764	46933764	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:46933764G>A	uc010acl.2	-	9	1727	c.1122C>T	c.(1120-1122)GTC>GTT	p.V374V	C13orf18_uc001vbf.3_Silent_p.V307V|C13orf18_uc001vbg.3_Silent_p.V102V|C13orf18_uc010tfz.1_Silent_p.V217V|C13orf18_uc010acm.2_Silent_p.V239V|C13orf18_uc010acn.2_Silent_p.V159V|C13orf18_uc001vbe.3_Silent_p.V374V|C13orf18_uc001vbh.3_Silent_p.V374V|C13orf18_uc001vbi.3_Silent_p.V217V|C13orf18_uc010aco.1_Silent_p.V374V	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	374											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58207580	58207580	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58207580C>T	uc001vhq.1	+	1	1792	c.900C>T	c.(898-900)ACC>ACT	p.T300T	PCDH17_uc010aec.1_Silent_p.T300T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	300	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
PCDH17	27253	broad.mit.edu	37	13	58208476	58208476	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:58208476G>A	uc001vhq.1	+	1	2688	c.1796G>A	c.(1795-1797)CGC>CAC	p.R599H	PCDH17_uc010aec.1_Missense_Mutation_p.R599H	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	599	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)														---	---	---	---
DIAPH3	81624	broad.mit.edu	37	13	60616846	60616846	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:60616846A>G	uc001vht.2	-	5	823	c.604T>C	c.(604-606)TCT>CCT	p.S202P	DIAPH3_uc001vhw.1_Missense_Mutation_p.S191P|DIAPH3_uc010aed.1_Missense_Mutation_p.S156P|DIAPH3_uc010aee.1_Missense_Mutation_p.S132P|uc001vhx.2_RNA	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	202	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)														---	---	---	---
POU4F1	5457	broad.mit.edu	37	13	79175961	79175961	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:79175961G>A	uc001vkv.2	-	2	1083	c.849C>T	c.(847-849)GGC>GGT	p.G283G	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	283	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)														---	---	---	---
DCT	1638	broad.mit.edu	37	13	95131418	95131418	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:95131418G>A	uc001vlv.3	-	1	519	c.92C>T	c.(91-93)ACG>ATG	p.T31M	DCT_uc010afh.2_Missense_Mutation_p.T31M	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	31	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)														---	---	---	---
HS6ST3	266722	broad.mit.edu	37	13	96743241	96743241	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:96743241G>A	uc001vmw.2	+	1	149	c.125G>A	c.(124-126)CGC>CAC	p.R42H		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	42	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)																	---	---	---	---
DOCK9	23348	broad.mit.edu	37	13	99505676	99505676	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:99505676T>G	uc001vnt.2	-	35	3990	c.3935A>C	c.(3934-3936)AAG>ACG	p.K1312T	DOCK9_uc001vnw.2_Missense_Mutation_p.K1311T|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.K1312T|DOCK9_uc010tip.1_5'UTR|DOCK9_uc010tiq.1_Missense_Mutation_p.K290T	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1312					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)																	---	---	---	---
ERCC5	2073	broad.mit.edu	37	13	103459927	103459927	+	Missense_Mutation	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103459927A>T	uc001vpu.1	+	1	432	c.310A>T	c.(310-312)AAT>TAT	p.N104Y	BIVM_uc001vps.2_Missense_Mutation_p.N104Y|BIVM_uc010agc.2_Intron|BIVM_uc001vpt.2_Missense_Mutation_p.N104Y	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	141					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)							Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
ERCC5	2073	broad.mit.edu	37	13	103514378	103514378	+	Splice_Site	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:103514378A>C	uc001vpw.2	+	8	1324	c.881_splice	c.e8-2	p.G294_splice	ERCC5_uc001vpu.1_Splice_Site_p.G748_splice|ERCC5_uc010tjb.1_Splice_Site_p.G294_splice|ERCC5_uc010tjc.1_Splice_Site|ERCC5_uc010tjd.1_Splice_Site_p.G126_splice	NM_000123	NP_000114			XPG-complementing protein						negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)							Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				---	---	---	---
FAM155A	728215	broad.mit.edu	37	13	108518130	108518130	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:108518130T>G	uc001vql.2	-	1	1331	c.815A>C	c.(814-816)GAC>GCC	p.D272A		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	272						integral to membrane	binding			skin(1)	1																		---	---	---	---
MYO16	23026	broad.mit.edu	37	13	109792754	109792754	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:109792754C>T	uc001vqt.1	+	32	4254	c.4128C>T	c.(4126-4128)CCC>CCT	p.P1376P	MYO16_uc010agk.1_Silent_p.P1398P	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1376					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)															---	---	---	---
IRS2	8660	broad.mit.edu	37	13	110434725	110434725	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:110434725C>T	uc001vqv.2	-	1	4190	c.3676G>A	c.(3676-3678)GGG>AGG	p.G1226R		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1226					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)															---	---	---	---
ATP11A	23250	broad.mit.edu	37	13	113505388	113505388	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:113505388T>C	uc001vsi.3	+	18	1935	c.1847T>C	c.(1846-1848)CTG>CCG	p.L616P	ATP11A_uc001vsj.3_Missense_Mutation_p.L616P|ATP11A_uc001vsm.1_Missense_Mutation_p.L492P|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	616	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)																---	---	---	---
TFDP1	7027	broad.mit.edu	37	13	114286057	114286057	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr13:114286057C>T	uc001vtw.2	+	5	518	c.306C>T	c.(304-306)GCC>GCT	p.A102A	TFDP1_uc010tkd.1_Intron|TFDP1_uc010tke.1_Intron|TFDP1_uc001vty.3_Silent_p.A102A|TFDP1_uc001vtx.2_5'Flank|TFDP1_uc010agx.2_Silent_p.A102A	NM_007111	NP_009042	Q14186	TFDP1_HUMAN	transcription factor Dp-1	102					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			lung(4)|ovary(2)|skin(1)	7	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)												TSP Lung(29;0.18)			---	---	---	---
OR4Q3	441669	broad.mit.edu	37	14	20216140	20216140	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:20216140T>C	uc010tkt.1	+	1	554	c.554T>C	c.(553-555)GTC>GCC	p.V185A		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	185	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)														---	---	---	---
FLJ10357	55701	broad.mit.edu	37	14	21549846	21549846	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:21549846G>A	uc001vzp.2	+	14	2848	c.2819G>A	c.(2818-2820)CGC>CAC	p.R940H	FLJ10357_uc001vzo.1_Missense_Mutation_p.R19H|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.R226H	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	940	Potential.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)														---	---	---	---
MMP14	4323	broad.mit.edu	37	14	23313866	23313866	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23313866C>T	uc001whc.2	+	8	1412	c.1178C>T	c.(1177-1179)GCG>GTG	p.A393V		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	393	Hemopexin-like 2.|Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23530627	23530627	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23530627G>A	uc001wit.3	-	17	3806	c.3478C>T	c.(3478-3480)CGA>TGA	p.R1160*	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Nonsense_Mutation_p.R402*|ACIN1_uc001wiq.3_Nonsense_Mutation_p.R402*|ACIN1_uc001wir.3_Nonsense_Mutation_p.R433*|ACIN1_uc001wis.3_Nonsense_Mutation_p.R841*|ACIN1_uc010akg.2_Nonsense_Mutation_p.R1147*	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1160	Arg/Asp/Glu/Lys-rich.		R -> Q (in a colorectal cancer sample; somatic mutation).		apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding	p.R1160Q(1)		ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
ACIN1	22985	broad.mit.edu	37	14	23530687	23530687	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23530687G>A	uc001wit.3	-	17	3746	c.3418C>T	c.(3418-3420)CGG>TGG	p.R1140W	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.R382W|ACIN1_uc001wiq.3_Missense_Mutation_p.R382W|ACIN1_uc001wir.3_Missense_Mutation_p.R413W|ACIN1_uc001wis.3_Missense_Mutation_p.R821W|ACIN1_uc010akg.2_Missense_Mutation_p.R1127W	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1140	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)														---	---	---	---
SLC22A17	51310	broad.mit.edu	37	14	23817841	23817841	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23817841G>A	uc001wjl.2	-	4	622	c.566C>T	c.(565-567)GCC>GTC	p.A189V	SLC22A17_uc010akk.2_Intron|SLC22A17_uc001wjn.2_Intron|SLC22A17_uc001wjm.2_Missense_Mutation_p.A189V|SLC22A17_uc010akl.1_3'UTR	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	189	Helical; (Potential).				siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)														---	---	---	---
EFS	10278	broad.mit.edu	37	14	23826481	23826481	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23826481C>A	uc001wjo.2	-	6	2248	c.1640G>T	c.(1639-1641)GGG>GTG	p.G547V	EFS_uc001wjp.2_Missense_Mutation_p.G454V|EFS_uc010tnm.1_Missense_Mutation_p.G378V	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	547					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)														---	---	---	---
CMTM5	116173	broad.mit.edu	37	14	23847614	23847614	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:23847614C>T	uc010akm.2	+	2	627	c.183C>T	c.(181-183)GCC>GCT	p.A61A	CMTM5_uc001wjs.2_Silent_p.A61A|CMTM5_uc001wjt.2_Silent_p.A61A|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	61	Helical; (Potential).|MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)														---	---	---	---
AP1G2	8906	broad.mit.edu	37	14	24032709	24032709	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24032709C>T	uc001wkl.2	-	14	1627	c.1290G>A	c.(1288-1290)GCG>GCA	p.A430A	AP1G2_uc001wkj.2_Silent_p.A49A|AP1G2_uc001wkk.3_Silent_p.A358A|AP1G2_uc001wkn.2_Silent_p.A49A|uc001wko.1_Intron|AP1G2_uc001wkp.1_RNA|AP1G2_uc010tnp.1_Silent_p.A430A	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	430					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)												OREG0022605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
DHRS4L1	728635	broad.mit.edu	37	14	24518539	24518539	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24518539C>T	uc010alc.2	+	9	721	c.721C>T	c.(721-723)CGG>TGG	p.R241W	DHRS4L1_uc010tnu.1_RNA|LRRC16B_uc001wlj.2_5'Flank	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	241							binding|oxidoreductase activity				0																		---	---	---	---
IPO4	79711	broad.mit.edu	37	14	24652846	24652846	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:24652846A>G	uc001wmv.1	-	20	2144	c.2013T>C	c.(2011-2013)GAT>GAC	p.D671D	IPO4_uc001wmt.1_Silent_p.D149D|IPO4_uc001wmu.2_Silent_p.D333D|IPO4_uc001wmx.1_Silent_p.D535D|IPO4_uc001wmy.1_Silent_p.D535D|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.D671D	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	671					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)														---	---	---	---
INSM2	84684	broad.mit.edu	37	14	36004942	36004942	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:36004942G>A	uc001wth.1	+	1	1695	c.1484G>A	c.(1483-1485)CGC>CAC	p.R495H		NM_032594	NP_115983	Q96T92	INSM2_HUMAN	insulinoma-associated protein IA-6	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(1)|skin(1)	2	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)														---	---	---	---
NKX2-8	26257	broad.mit.edu	37	14	37051430	37051430	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:37051430G>A	uc001wtx.2	-							NM_014360	NP_055175			NK2 homeobox 8						liver development|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(36;0.143)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.0113)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0171)														---	---	---	---
SSTR1	6751	broad.mit.edu	37	14	38678848	38678848	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38678848G>A	uc001wul.1	+	3	871	c.254G>A	c.(253-255)CGC>CAC	p.R85H	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	85	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)													---	---	---	---
SSTR1	6751	broad.mit.edu	37	14	38679088	38679088	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:38679088C>T	uc001wul.1	+	3	1111	c.494C>T	c.(493-495)GCG>GTG	p.A165V	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	165	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)													---	---	---	---
SEC23A	10484	broad.mit.edu	37	14	39565189	39565189	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39565189A>G	uc001wup.1	-	2	357	c.134T>C	c.(133-135)CTG>CCG	p.L45P	SEC23A_uc010tqa.1_Intron|SEC23A_uc010tqb.1_Missense_Mutation_p.L45P	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	45					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)														---	---	---	---
PNN	5411	broad.mit.edu	37	14	39649724	39649724	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:39649724C>T	uc001wuw.3	+	9	908	c.811C>T	c.(811-813)CGC>TGC	p.R271C		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	271	Necessary for interaction with RNPS1.|Glu-rich.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)														---	---	---	---
PYGL	5836	broad.mit.edu	37	14	51381427	51381427	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:51381427T>C	uc001wyu.2	-	12	1637	c.1510A>G	c.(1510-1512)ATA>GTA	p.I504V	PYGL_uc010tqq.1_Missense_Mutation_p.I470V|PYGL_uc001wyv.2_Missense_Mutation_p.I178V	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	504					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)													---	---	---	---
PTGDR	5729	broad.mit.edu	37	14	52734813	52734813	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52734813G>T	uc001wzq.2	+	1	383	c.281G>T	c.(280-282)CGG>CTG	p.R94L		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	94	Extracellular (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)													---	---	---	---
PTGER2	5732	broad.mit.edu	37	14	52781670	52781670	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:52781670A>G	uc001wzr.2	+	1	655	c.404A>G	c.(403-405)TAC>TGC	p.Y135C		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	135	Cytoplasmic (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)													---	---	---	---
BMP4	652	broad.mit.edu	37	14	54418739	54418739	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:54418739G>A	uc001xal.3	-	2	389	c.202C>T	c.(202-204)CGC>TGC	p.R68C	BMP4_uc010aoh.2_Missense_Mutation_p.R68C|BMP4_uc001xao.3_Missense_Mutation_p.R68C|BMP4_uc001xan.3_Missense_Mutation_p.R68C	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	68					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0																		---	---	---	---
ACTR10	55860	broad.mit.edu	37	14	58690342	58690342	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:58690342C>T	uc001xdf.2	+	9	740	c.637C>T	c.(637-639)CGT>TGT	p.R213C	C14orf37_uc010tro.1_Intron|ACTR10_uc001xdg.2_Missense_Mutation_p.R15C|ACTR10_uc001xdh.2_Missense_Mutation_p.R15C|ACTR10_uc010trp.1_RNA|ACTR10_uc010apc.2_Missense_Mutation_p.R3C	NM_018477	NP_060947	Q9NZ32	ARP10_HUMAN	uncharacterized hypothalamus protein HARP11	213						cytoplasm				central_nervous_system(1)	1																		---	---	---	---
RTN1	6252	broad.mit.edu	37	14	60070603	60070603	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60070603C>T	uc001xen.1	-	6	2358	c.2149G>A	c.(2149-2151)GCT>ACT	p.A717T	RTN1_uc001xem.1_Missense_Mutation_p.A297T|RTN1_uc001xek.1_Missense_Mutation_p.A149T|RTN1_uc001xel.1_RNA|RTN1_uc010apl.1_Missense_Mutation_p.A134T	NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	717	Helical; (Potential).|Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)														---	---	---	---
RTN1	6252	broad.mit.edu	37	14	60213015	60213015	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60213015C>T	uc001xen.1	-	2	635	c.426G>A	c.(424-426)GAG>GAA	p.E142E		NM_021136	NP_066959	Q16799	RTN1_HUMAN	reticulon 1 isoform A	142					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0968)														---	---	---	---
SIX6	4990	broad.mit.edu	37	14	60976626	60976626	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:60976626G>A	uc001xfa.3	+	1	689	c.510G>A	c.(508-510)ACG>ACA	p.T170T		NM_007374	NP_031400	O95475	SIX6_HUMAN	SIX homeobox 6	170	Homeobox.				organ morphogenesis|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.088)														---	---	---	---
HIF1A	3091	broad.mit.edu	37	14	62187241	62187241	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:62187241G>A	uc001xfq.2	+	2	581	c.177G>A	c.(175-177)GTG>GTA	p.V59V	HIF1A_uc010tsc.1_Intron|HIF1A_uc001xfr.2_Silent_p.V59V|HIF1A_uc001xfs.2_Silent_p.V60V	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	59	Interaction with TSGA10 (By similarity).|Helix-loop-helix motif.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)														---	---	---	---
RBM25	58517	broad.mit.edu	37	14	73544119	73544119	+	Missense_Mutation	SNP	G	A	A	rs143840737	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:73544119G>A	uc001xno.2	+	4	407	c.199G>A	c.(199-201)GCA>ACA	p.A67T	RBM25_uc001xnn.3_Missense_Mutation_p.A67T|RBM25_uc010ttu.1_Missense_Mutation_p.A67T|RBM25_uc001xnp.2_5'UTR	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	67					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)														---	---	---	---
LTBP2	4053	broad.mit.edu	37	14	74970717	74970717	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:74970717C>T	uc001xqa.2	-	31	4881	c.4494G>A	c.(4492-4494)CCG>CCA	p.P1498P		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1498	EGF-like 17; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)														---	---	---	---
KIAA0317	9870	broad.mit.edu	37	14	75151323	75151323	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75151323G>A	uc001xqb.2	-	4	582	c.77C>T	c.(76-78)GCC>GTC	p.A26V	KIAA0317_uc010tut.1_Intron|KIAA0317_uc001xqc.2_Missense_Mutation_p.A26V|KIAA0317_uc001xqd.1_Intron	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	26					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)														---	---	---	---
YLPM1	56252	broad.mit.edu	37	14	75277083	75277083	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75277083C>T	uc001xqj.3	+	9	5312	c.5188C>T	c.(5188-5190)CGG>TGG	p.R1730W	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.R213W	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1535	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)														---	---	---	---
TMED10	10972	broad.mit.edu	37	14	75602475	75602475	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:75602475G>A	uc001xrm.1	-	4	593	c.526C>T	c.(526-528)CGT>TGT	p.R176C	TMED10_uc010ash.1_RNA|TMED10_uc010asg.1_RNA|TMED10_uc010tuz.1_Missense_Mutation_p.R51C	NM_006827	NP_006818	P49755	TMEDA_HUMAN	transmembrane emp24 domain-containing protein 10	176	Lumenal (Potential).|GOLD.				protein transport|regulated secretory pathway|vesicle targeting, to, from or within Golgi	cis-Golgi network|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|melanosome|microsome|zymogen granule membrane	protein binding				0				BRCA - Breast invasive adenocarcinoma(234;0.0126)														---	---	---	---
GALC	2581	broad.mit.edu	37	14	88450866	88450866	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:88450866A>G	uc001xvt.2	-	5	853	c.454T>C	c.(454-456)TCA>CCA	p.S152P	GALC_uc010tvx.1_Missense_Mutation_p.S126P|GALC_uc010tvy.1_Missense_Mutation_p.S129P|GALC_uc010tvz.1_Missense_Mutation_p.S96P|GALC_uc001xvu.1_Missense_Mutation_p.S152P	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	152					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0																		---	---	---	---
CATSPERB	79820	broad.mit.edu	37	14	92047403	92047403	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:92047403C>T	uc001xzs.1	-	27	3321	c.3181G>A	c.(3181-3183)GCC>ACC	p.A1061T	CATSPERB_uc010aub.1_Missense_Mutation_p.A583T	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	1061	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)																---	---	---	---
SERPINA3	12	broad.mit.edu	37	14	95058423	95058423	+	Translation_Start_Site	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95058423C>T	uc001ydo.3	+	1	29	c.-859C>T	c.(-861--857)GACGA>GATGA		SERPINA5_uc001ydm.2_Silent_p.D356D	NM_001085	NP_001076			serpin peptidase inhibitor, clade A, member 3						acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)														---	---	---	---
SERPINA3	12	broad.mit.edu	37	14	95080920	95080920	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:95080920G>A	uc001ydp.2	+	2	221	c.142G>A	c.(142-144)GGA>AGA	p.G48R	SERPINA3_uc001ydo.3_Missense_Mutation_p.G73R|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.G48R|SERPINA3_uc001yds.2_Missense_Mutation_p.G48R|SERPINA3_uc010avg.2_Missense_Mutation_p.G48R	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	48					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)														---	---	---	---
BDKRB1	623	broad.mit.edu	37	14	96731019	96731019	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96731019A>C	uc001yfh.2	+	3	1208	c.1000A>C	c.(1000-1002)AGT>CGT	p.S334R	BDKRB1_uc010avn.2_Intron	NM_000710	NP_000701	P46663	BKRB1_HUMAN	bradykinin receptor B1	334	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			ovary(3)	3		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)														---	---	---	---
ATG2B	55102	broad.mit.edu	37	14	96752327	96752327	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:96752327G>A	uc001yfi.2	-							NM_018036	NP_060506			ATG2 autophagy related 2 homolog B											ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)														---	---	---	---
HSP90AA1	3320	broad.mit.edu	37	14	102550309	102550309	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:102550309C>A	uc001yku.3	-	7	1349	c.1159G>T	c.(1159-1161)GGG>TGG	p.G387W	HSP90AA1_uc001ykv.3_Missense_Mutation_p.G509W|HSP90AA1_uc001ykw.1_Missense_Mutation_p.G208W|HSP90AA1_uc001ykx.1_Missense_Mutation_p.G376W	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	387					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)													---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105410843	105410843	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105410843T>C	uc010axc.1	-	7	11065	c.10945A>G	c.(10945-10947)AGG>GGG	p.R3649G	AHNAK2_uc001ypx.2_Missense_Mutation_p.R3549G	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3649						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105410862	105410862	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105410862T>C	uc010axc.1	-	7	11046	c.10926A>G	c.(10924-10926)AAA>AAG	p.K3642K	AHNAK2_uc001ypx.2_Silent_p.K3542K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3642						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
AHNAK2	113146	broad.mit.edu	37	14	105418827	105418827	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105418827G>A	uc010axc.1	-	7	3081	c.2961C>T	c.(2959-2961)GCC>GCT	p.A987A	AHNAK2_uc001ypx.2_Silent_p.A887A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	987						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)															---	---	---	---
TMEM121	80757	broad.mit.edu	37	14	105995483	105995483	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr14:105995483G>A	uc001yrp.1	+	2	463	c.312G>A	c.(310-312)GCG>GCA	p.A104A	ADAM6_uc010tyt.1_Intron|uc001yrr.2_5'Flank	NM_025268	NP_079544	Q9BTD3	TM121_HUMAN	hole protein	104						integral to membrane					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.0959)|all cancers(159;0.235)														---	---	---	---
Unknown	0	broad.mit.edu	37	15	22466321	22466321	+	5'Flank	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:22466321C>A	uc001yui.1	-											Homo sapiens clone IgA5728-2 immunoglobulin A heavy chain mRNA, partial cds.																														---	---	---	---
C15orf2	23742	broad.mit.edu	37	15	24923884	24923884	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:24923884C>T	uc001ywo.2	+	1	3344	c.2870C>T	c.(2869-2871)ACA>ATA	p.T957I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	957					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)														---	---	---	---
ATP10A	57194	broad.mit.edu	37	15	25947181	25947181	+	Missense_Mutation	SNP	G	A	A	rs142704035		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:25947181G>A	uc010ayu.2	-	13	2748	c.2642C>T	c.(2641-2643)GCG>GTG	p.A881V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	881	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)														---	---	---	---
OCA2	4948	broad.mit.edu	37	15	28090178	28090178	+	Missense_Mutation	SNP	C	T	T	rs142988897	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28090178C>T	uc001zbh.3	-	23	2469	c.2359G>A	c.(2359-2361)GCG>ACG	p.A787T	OCA2_uc010ayv.2_Missense_Mutation_p.A763T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	787	Extracellular (Potential).		A -> V (in OCA2).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)										Oculocutaneous_Albinism				---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28437288	28437288	+	Missense_Mutation	SNP	G	A	A	rs61755662	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28437288G>A	uc001zbj.2	-	53	8376	c.8270C>T	c.(8269-8271)GCG>GTG	p.A2757V	HERC2_uc001zbk.1_Missense_Mutation_p.A292V	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2757					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)												OREG0022997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
HERC2	8924	broad.mit.edu	37	15	28493767	28493767	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:28493767G>A	uc001zbj.2	-	21	3272	c.3166C>T	c.(3166-3168)CGT>TGT	p.R1056C		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1056					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)														---	---	---	---
APBA2	321	broad.mit.edu	37	15	29397613	29397613	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:29397613C>T	uc001zck.2	+	10	1763	c.1556C>T	c.(1555-1557)GCC>GTC	p.A519V	APBA2_uc010azj.2_Missense_Mutation_p.A507V|APBA2_uc010uat.1_Missense_Mutation_p.A507V|APBA2_uc001zcl.2_Missense_Mutation_p.A507V	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	519	PID.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)														---	---	---	---
TJP1	7082	broad.mit.edu	37	15	30001145	30001145	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:30001145G>A	uc001zcr.2	-	25	4943	c.4468C>T	c.(4468-4470)CGA>TGA	p.R1490*	TJP1_uc010azl.2_Nonsense_Mutation_p.R1478*|TJP1_uc001zcq.2_Nonsense_Mutation_p.R1414*|TJP1_uc001zcs.2_Nonsense_Mutation_p.R1410*	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1490					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)														---	---	---	---
TJP1	7082	broad.mit.edu	37	15	30010706	30010706	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:30010706A>C	uc001zcr.2	-	21	4115	c.3640T>G	c.(3640-3642)TTT>GTT	p.F1214V	TJP1_uc010azl.2_Missense_Mutation_p.F1202V|TJP1_uc001zcq.2_Missense_Mutation_p.F1138V|TJP1_uc001zcs.2_Missense_Mutation_p.F1134V	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1214					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)														---	---	---	---
CHRFAM7A	89832	broad.mit.edu	37	15	30659642	30659642	+	Silent	SNP	G	A	A	rs149651405		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:30659642G>A	uc001zdt.1	-	9	1265	c.699C>T	c.(697-699)GAC>GAT	p.D233D	DKFZP434L187_uc001zds.2_Intron|CHRFAM7A_uc001zdu.1_Silent_p.D142D|CHRFAM7A_uc010azn.2_Silent_p.D142D	NM_139320	NP_647536	Q494W8	CRFM7_HUMAN	CHRNA7-FAM7A fusion isoform 1	233						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			skin(1)	1		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)														---	---	---	---
MTMR10	54893	broad.mit.edu	37	15	31233850	31233850	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:31233850G>A	uc001zfh.1	-	16	2255	c.2157C>T	c.(2155-2157)AAC>AAT	p.N719N	MTMR15_uc001zff.2_3'UTR|MTMR15_uc001zfe.2_3'UTR|MTMR10_uc010ubk.1_Silent_p.N133N|MTMR10_uc001zfg.1_Silent_p.N300N|MTMR10_uc010azx.1_Silent_p.N471N|MTMR10_uc001zfi.1_3'UTR	NM_017762	NP_060232	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	719							phosphatase activity			ovary(1)	1		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)														---	---	---	---
C15orf55	256646	broad.mit.edu	37	15	34647736	34647736	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:34647736G>A	uc001zif.2	+	7	1598	c.1443G>A	c.(1441-1443)GAG>GAA	p.E481E	C15orf55_uc010ucc.1_Silent_p.E509E|C15orf55_uc010ucd.1_Silent_p.E499E	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	481						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)				T	BRD3|BRD4	lethal midline carcinoma								---	---	---	---
THBS1	7057	broad.mit.edu	37	15	39885703	39885703	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:39885703G>A	uc001zkh.2	+	19	3280	c.3101G>A	c.(3100-3102)CGC>CAC	p.R1034H	THBS1_uc010bbi.2_Missense_Mutation_p.R506H	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	1034	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)													---	---	---	---
FSIP1	161835	broad.mit.edu	37	15	39910098	39910098	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:39910098C>T	uc001zki.2	-	11	1755	c.1537G>A	c.(1537-1539)GTT>ATT	p.V513I		NM_152597	NP_689810	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	513										ovary(2)|skin(1)	3		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)														---	---	---	---
EHD4	30844	broad.mit.edu	37	15	42193061	42193061	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:42193061C>T	uc001zot.2	-	6	1471	c.1408G>A	c.(1408-1410)GCC>ACC	p.A470T		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	470	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)														---	---	---	---
TTBK2	146057	broad.mit.edu	37	15	43067849	43067849	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43067849G>A	uc001zqo.2	-	13	1921	c.1482C>T	c.(1480-1482)TGC>TGT	p.C494C	TTBK2_uc010bcy.2_Silent_p.C425C	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	494					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)														---	---	---	---
LCMT2	9836	broad.mit.edu	37	15	43622547	43622547	+	Silent	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43622547G>C	uc001zrg.2	-	1	345	c.141C>G	c.(139-141)CGC>CGG	p.R47R	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	47					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)													---	---	---	---
MAP1A	4130	broad.mit.edu	37	15	43815948	43815948	+	Silent	SNP	G	A	A	rs142195148	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:43815948G>A	uc001zrt.2	+	4	2744	c.2277G>A	c.(2275-2277)CCG>CCA	p.P759P		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	759						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)													---	---	---	---
WDR76	79968	broad.mit.edu	37	15	44127282	44127282	+	Silent	SNP	C	T	T	rs146443201	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:44127282C>T	uc001zti.1	+	3	509	c.486C>T	c.(484-486)TAC>TAT	p.Y162Y		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	162											0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)														---	---	---	---
COPS2	9318	broad.mit.edu	37	15	49431799	49431799	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:49431799G>A	uc001zxf.2	-	4	377	c.298C>T	c.(298-300)CGG>TGG	p.R100W	COPS2_uc001zxh.2_Missense_Mutation_p.R100W|COPS2_uc010ufa.1_Missense_Mutation_p.R36W	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	100					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)														---	---	---	---
TNFAIP8L3	388121	broad.mit.edu	37	15	51350305	51350305	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51350305C>T	uc001zyy.2	-	3	752	c.652G>A	c.(652-654)GAT>AAT	p.D218N		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	218											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)														---	---	---	---
GLDN	342035	broad.mit.edu	37	15	51696776	51696776	+	Missense_Mutation	SNP	T	C	C	rs145926803		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:51696776T>C	uc002aba.2	+	10	1650	c.1481T>C	c.(1480-1482)TTT>TCT	p.F494S	GLDN_uc002abb.2_Missense_Mutation_p.F370S	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	494	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)														---	---	---	---
ONECUT1	3175	broad.mit.edu	37	15	53081088	53081088	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:53081088G>A	uc002aci.1	-	1	1122	c.994C>T	c.(994-996)CGC>TGC	p.R332C		NM_004498	NP_004489	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	332	CUT.				endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding				0				all cancers(107;0.0708)														---	---	---	---
UNC13C	440279	broad.mit.edu	37	15	54804032	54804032	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:54804032G>A	uc002ack.2	+							NM_001080534	NP_001074003			unc-13 homolog C						exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)														---	---	---	---
LIPC	3990	broad.mit.edu	37	15	58724239	58724239	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:58724239C>T	uc010bga.1	+	3	616	c.8C>T	c.(7-9)ACA>ATA	p.T3I	LIPC_uc010bfz.1_Missense_Mutation_p.T3I|LIPC_uc002afa.1_Missense_Mutation_p.T3I|LIPC_uc010bgb.1_5'UTR|LIPC_uc010ugy.1_Missense_Mutation_p.T3I	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	3					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)														---	---	---	---
DENND4A	10260	broad.mit.edu	37	15	65954190	65954190	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:65954190T>C	uc002aph.2	-	32	5969	c.5591A>G	c.(5590-5592)TAA>TGA	p.*1864*	DENND4A_uc002api.2_Silent_p.*1907*	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1864					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4																		---	---	---	---
RPL4	6124	broad.mit.edu	37	15	66793741	66793741	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:66793741A>G	uc002apv.2	-	6	704	c.648T>C	c.(646-648)GGT>GGC	p.G216G	RPL4_uc010bhr.2_Silent_p.G122G|RPL4_uc002apw.2_Silent_p.G122G|RPL4_uc002apx.2_Silent_p.G122G|RPL4_uc010ujq.1_Silent_p.G216G|SNORD18C_uc010bhs.1_5'Flank	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	216					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0																		---	---	---	---
IQCH	64799	broad.mit.edu	37	15	67664607	67664607	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:67664607C>T	uc002aqo.1	+	9	959	c.912C>T	c.(910-912)CAC>CAT	p.H304H	IQCH_uc010ujv.1_Silent_p.H123H|IQCH_uc002aqn.1_Silent_p.H131H|IQCH_uc002aqq.1_Silent_p.H52H|IQCH_uc002aqp.1_Silent_p.H56H	NM_001031715	NP_001026885	Q86VS3	IQCH_HUMAN	IQ motif containing H isoform 1	304										skin(3)|ovary(1)	4				Colorectal(3;0.0856)														---	---	---	---
ITGA11	22801	broad.mit.edu	37	15	68612614	68612614	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68612614G>A	uc002ari.2	-	20	2612	c.2525C>T	c.(2524-2526)GCC>GTC	p.A842V	ITGA11_uc010bib.2_Missense_Mutation_p.A842V	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	842	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)													---	---	---	---
ITGA11	22801	broad.mit.edu	37	15	68619102	68619102	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:68619102G>A	uc002ari.2	-	17	2188	c.2101C>T	c.(2101-2103)CGG>TGG	p.R701W	ITGA11_uc010bib.2_Missense_Mutation_p.R701W	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	701	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)													---	---	---	---
KIF23	9493	broad.mit.edu	37	15	69709798	69709798	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:69709798A>G	uc002asb.2	+	3	275	c.158A>G	c.(157-159)CAG>CGG	p.Q53R	KIF23_uc002asc.2_Missense_Mutation_p.Q53R|KIF23_uc010bii.2_5'UTR|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	53	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0																		---	---	---	---
NEO1	4756	broad.mit.edu	37	15	73585744	73585744	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73585744C>A	uc002avm.3	+	26	3898	c.3756C>A	c.(3754-3756)GCC>GCA	p.A1252A	NEO1_uc010ukx.1_Silent_p.A1241A|NEO1_uc010uky.1_Intron|NEO1_uc010ukz.1_Silent_p.A665A|NEO1_uc002avn.3_Silent_p.A890A	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	1252	Cytoplasmic (Potential).				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1																		---	---	---	---
HCN4	10021	broad.mit.edu	37	15	73615907	73615907	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:73615907C>T	uc002avp.2	-	8	3521	c.2527G>A	c.(2527-2529)GCC>ACC	p.A843T		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	843	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)														---	---	---	---
STRA6	64220	broad.mit.edu	37	15	74488486	74488486	+	Missense_Mutation	SNP	G	T	T	rs118203961		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74488486G>T	uc002axk.2	-	5	451	c.269C>A	c.(268-270)CCT>CAT	p.P90H	STRA6_uc002axi.2_Translation_Start_Site|STRA6_uc010ulh.1_Missense_Mutation_p.P128H|STRA6_uc002axj.2_Missense_Mutation_p.P129H|STRA6_uc010bji.2_Missense_Mutation_p.P90H|STRA6_uc002axl.2_Missense_Mutation_p.P22H|STRA6_uc002axm.2_Missense_Mutation_p.P90H|STRA6_uc002axn.2_Intron|STRA6_uc010uli.1_Missense_Mutation_p.P127H|STRA6_uc010bjj.1_RNA|STRA6_uc010bjk.2_Missense_Mutation_p.P90H	NM_022369	NP_071764	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid gene 6 homolog	90	Cytoplasmic (Potential).		P -> L (in MCOPS9).		adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			central_nervous_system(1)	1																		---	---	---	---
CLK3	1198	broad.mit.edu	37	15	74911653	74911653	+	Missense_Mutation	SNP	G	A	A	rs150279637		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:74911653G>A	uc010uln.1	+	2	1021	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	CLK3_uc002ayg.3_Missense_Mutation_p.R39Q|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Missense_Mutation_p.R187Q|CLK3_uc002ayj.3_Missense_Mutation_p.R39Q|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	187	Arg-rich.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2																		---	---	---	---
SGK269	79834	broad.mit.edu	37	15	77473380	77473380	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:77473380G>A	uc002bcm.2	-	3	1197	c.889C>T	c.(889-891)CGA>TGA	p.R297*	SGK269_uc002bcn.2_Nonsense_Mutation_p.R297*	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	297					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)														---	---	---	---
CHRNB4	1143	broad.mit.edu	37	15	78921959	78921959	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:78921959G>A	uc002bed.1	-	5	800	c.688C>T	c.(688-690)CGC>TGC	p.R230C	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.R48C	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	230	Extracellular (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0																		---	---	---	---
AP3B2	8120	broad.mit.edu	37	15	83350299	83350299	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:83350299G>A	uc010uoh.1	-	5	571	c.394C>T	c.(394-396)CGT>TGT	p.R132C	AP3B2_uc010uoi.1_Missense_Mutation_p.R132C|AP3B2_uc010uoj.1_Missense_Mutation_p.R100C|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	132					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)															---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86028977	86028977	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86028977C>T	uc002blv.1	+	2	196	c.26C>T	c.(25-27)CCC>CTC	p.P9L	AKAP13_uc002bls.2_Missense_Mutation_p.P9L|AKAP13_uc002blt.1_Missense_Mutation_p.P9L|AKAP13_uc002blu.1_Missense_Mutation_p.P9L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	9					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
AKAP13	11214	broad.mit.edu	37	15	86118351	86118351	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86118351C>T	uc002blv.1	+						AKAP13_uc002blt.1_Intron|AKAP13_uc002blu.1_Intron	NM_007200	NP_009131			A-kinase anchor protein 13 isoform 2						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9																		---	---	---	---
AGBL1	123624	broad.mit.edu	37	15	86814885	86814885	+	Missense_Mutation	SNP	C	G	G	rs147544569	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:86814885C>G	uc002blz.1	+	14	1965	c.1885C>G	c.(1885-1887)CTT>GTT	p.L629V	AGBL1_uc002bma.1_Missense_Mutation_p.L360V|AGBL1_uc002bmb.1_Missense_Mutation_p.L323V	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	629					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0																		---	---	---	---
ACAN	176	broad.mit.edu	37	15	89382169	89382169	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:89382169G>A	uc010upo.1	+	3	720	c.346G>A	c.(346-348)GCC>ACC	p.A116T	ACAN_uc002bmx.2_Missense_Mutation_p.A116T|ACAN_uc010upp.1_Missense_Mutation_p.A116T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	116					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)															---	---	---	---
SEMA4B	10509	broad.mit.edu	37	15	90771643	90771643	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90771643G>A	uc002boy.2	+	15	2565	c.2282G>A	c.(2281-2283)TGC>TAC	p.C761Y	SEMA4B_uc002boz.2_Missense_Mutation_p.C761Y|SEMA4B_uc010uqd.1_Missense_Mutation_p.C599Y|SEMA4B_uc002bpa.2_Missense_Mutation_p.C599Y|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)															---	---	---	---
TTLL13	440307	broad.mit.edu	37	15	90796498	90796498	+	Missense_Mutation	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:90796498A>T	uc002bpd.1	+	4	604	c.316A>T	c.(316-318)ATG>TTG	p.M106L	TTLL13_uc002bpe.1_RNA	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	106	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)															---	---	---	---
BLM	641	broad.mit.edu	37	15	91354578	91354578	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91354578C>A	uc002bpr.2	+	21	4115	c.4018C>A	c.(4018-4020)CCA>ACA	p.P1340T	BLM_uc010uqh.1_Missense_Mutation_p.P1340T|BLM_uc010uqi.1_Missense_Mutation_p.P965T|BLM_uc010bnx.2_Missense_Mutation_p.P1209T|BLM_uc002bpt.2_Missense_Mutation_p.P315T	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	1340	Nuclear localization signal (Potential).				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)					Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				---	---	---	---
FES	2242	broad.mit.edu	37	15	91434325	91434325	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:91434325G>A	uc002bpv.2	+	11	1530	c.1434G>A	c.(1432-1434)GGG>GGA	p.G478G	FES_uc010uqj.1_Intron|FES_uc010uqk.1_Silent_p.G460G|FES_uc002bpw.2_RNA|FES_uc010bny.2_Intron|FES_uc002bpx.2_Intron|FES_uc002bpy.2_Silent_p.G420G	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	478	SH2.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)															---	---	---	---
ALDH1A3	220	broad.mit.edu	37	15	101440957	101440957	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101440957G>T	uc002bwn.3	+	9	1165	c.1061G>T	c.(1060-1062)GGG>GTG	p.G354V	ALDH1A3_uc010bpb.2_Missense_Mutation_p.G247V|uc002bwo.1_Intron	NM_000693	NP_000684	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1A3	354					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			central_nervous_system(2)|lung(1)|pancreas(1)	4	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)													---	---	---	---
LRRK1	79705	broad.mit.edu	37	15	101529526	101529526	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr15:101529526C>T	uc002bwr.2	+	6	1004	c.685C>T	c.(685-687)CCT>TCT	p.P229S	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bwq.1_Missense_Mutation_p.P229S	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	229					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)															---	---	---	---
AXIN1	8312	broad.mit.edu	37	16	396464	396464	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:396464C>T	uc002cgp.1	-	2	739	c.562G>A	c.(562-564)GAA>AAA	p.E188K	AXIN1_uc002cgq.1_Missense_Mutation_p.E188K	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	188	RGS.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)														OREG0003698	type=REGULATORY REGION|Gene=AXIN1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	---	---	---	---
TMEM8A	58986	broad.mit.edu	37	16	426792	426792	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:426792G>A	uc002cgu.3	-	5	785	c.656C>T	c.(655-657)ACG>ATG	p.T219M	TMEM8A_uc002cgv.3_Missense_Mutation_p.T26M	NM_021259	NP_067082	Q9HCN3	TMM8A_HUMAN	transmembrane protein 8 (five membrane-spanning	219	Extracellular (Potential).				cell adhesion	integral to plasma membrane				central_nervous_system(2)|pancreas(1)	3																		---	---	---	---
NHLRC4	283948	broad.mit.edu	37	16	618088	618088	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:618088C>T	uc002chl.2	+	2	637	c.41C>T	c.(40-42)CCT>CTT	p.P14L	PIGQ_uc010bqw.2_Intron|PIGQ_uc002chm.2_5'Flank|PIGQ_uc002chn.2_5'Flank|PIGQ_uc002cho.2_5'Flank	NM_176677	NP_788850	P0CG21	NHLC4_HUMAN	hypothetical protein LOC283948	14											0																		---	---	---	---
STUB1	10273	broad.mit.edu	37	16	731217	731217	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:731217G>A	uc002cit.2	+	2	636	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	STUB1_uc002ciu.2_Silent_p.Q3Q|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	75	TPR 2.				cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)																---	---	---	---
UNKL	64718	broad.mit.edu	37	16	1417206	1417206	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1417206C>T	uc002cln.2	-	5	817	c.430G>A	c.(430-432)GTA>ATA	p.V144I	UNKL_uc010brn.1_Intron|UNKL_uc002clo.2_Missense_Mutation_p.V141I|UNKL_uc002clp.2_Intron	NM_023076	NP_075564	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)																---	---	---	---
EME2	197342	broad.mit.edu	37	16	1823424	1823424	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1823424C>T	uc002cmq.1	+	1	196	c.196C>T	c.(196-198)CTG>TTG	p.L66L	NME3_uc002cmm.2_5'Flank|NME3_uc010brv.2_5'Flank|MRPS34_uc002cmn.2_5'Flank|MRPS34_uc002cmo.2_5'Flank|MRPS34_uc002cmp.1_5'Flank|EME2_uc010brw.1_Silent_p.L66L	NM_001010865	NP_001010865	A4GXA9	EME2_HUMAN	essential meiotic endonuclease 1 homolog 2	66					DNA recombination|DNA repair	nucleus	DNA binding|endonuclease activity			lung(1)|central_nervous_system(1)|pancreas(1)	3													Direct_reversal_of_damage|Homologous_recombination					---	---	---	---
NUBP2	10101	broad.mit.edu	37	16	1836845	1836845	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:1836845G>A	uc002cmw.3	+	3	312	c.223G>A	c.(223-225)GGC>AGC	p.G75S	NUBP2_uc002cmx.3_Intron|NUBP2_uc010brx.2_Missense_Mutation_p.G15S	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	75						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0																		---	---	---	---
ZNF598	90850	broad.mit.edu	37	16	2051158	2051158	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2051158G>A	uc002cof.1	-	9	1063	c.1048C>T	c.(1048-1050)CGG>TGG	p.R350W	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	350						intracellular	zinc ion binding			lung(1)|breast(1)	2																		---	---	---	---
ZNF598	90850	broad.mit.edu	37	16	2052542	2052542	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2052542G>A	uc002cof.1	-	6	672	c.657C>T	c.(655-657)GAC>GAT	p.D219D	ZNF598_uc002coe.1_5'Flank	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	219						intracellular	zinc ion binding			lung(1)|breast(1)	2																		---	---	---	---
TSC2	7249	broad.mit.edu	37	16	2138133	2138133	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2138133A>G	uc002con.2	+	40	5259	c.5153A>G	c.(5152-5154)CAC>CGC	p.H1718R	TSC2_uc010bsd.2_Missense_Mutation_p.H1695R|TSC2_uc002coo.2_Missense_Mutation_p.H1651R|TSC2_uc010uvv.1_Missense_Mutation_p.H1615R|TSC2_uc010uvw.1_Missense_Mutation_p.H1603R|TSC2_uc002cop.2_Missense_Mutation_p.H1474R|TSC2_uc002coq.2_Missense_Mutation_p.H493R|TSC2_uc002cor.2_Missense_Mutation_p.H419R	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1718	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)						D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				---	---	---	---
DNASE1L2	1775	broad.mit.edu	37	16	2287831	2287831	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2287831G>A	uc002cpo.2	+	5	1049	c.655G>A	c.(655-657)GCC>ACC	p.A219T	DNASE1L2_uc002cpn.2_Missense_Mutation_p.A198T|DNASE1L2_uc002cpp.2_Missense_Mutation_p.A219T|DNASE1L2_uc002cpq.2_Missense_Mutation_p.A219T	NM_001374	NP_001365	Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2 precursor	219					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding				0																		---	---	---	---
ABCA3	21	broad.mit.edu	37	16	2367638	2367638	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2367638G>A	uc002cpy.1	-						ABCA3_uc010bsk.1_Intron|ABCA3_uc010bsl.1_Intron	NM_001089	NP_001080			ATP-binding cassette, sub-family A member 3						response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)																---	---	---	---
SRRM2	23524	broad.mit.edu	37	16	2809397	2809397	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:2809397G>A	uc002crk.2	+	8	1283	c.734G>A	c.(733-735)CGA>CAA	p.R245Q	SRRM2_uc002crj.1_Missense_Mutation_p.R149Q|SRRM2_uc002crl.1_Missense_Mutation_p.R245Q|SRRM2_uc010bsu.1_Missense_Mutation_p.R149Q	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	245	Sufficient for RNA-binding.|Lys-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
PKMYT1	9088	broad.mit.edu	37	16	3024408	3024408	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3024408G>A	uc002csn.2	-	6	1433	c.990C>T	c.(988-990)TCC>TCT	p.S330S	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.S330S|PKMYT1_uc002cso.2_Silent_p.S261S|PKMYT1_uc002csp.2_Silent_p.S321S|PKMYT1_uc002csq.2_Silent_p.S321S|PKMYT1_uc010bsy.1_Silent_p.S321S	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	330	Protein kinase.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1																		---	---	---	---
CLDN9	9080	broad.mit.edu	37	16	3063742	3063742	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:3063742C>T	uc010uwo.1	+	1	1286	c.379C>T	c.(379-381)CTC>TTC	p.L127F		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	127	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
ADCY9	115	broad.mit.edu	37	16	4165257	4165257	+	Missense_Mutation	SNP	C	T	T	rs147045155	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4165257C>T	uc002cvx.2	-	2	726	c.187G>A	c.(187-189)GTC>ATC	p.V63I		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	63	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6																		---	---	---	---
PPL	5493	broad.mit.edu	37	16	4934126	4934126	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:4934126G>A	uc002cyd.1	-	22	4620	c.4530C>T	c.(4528-4530)GGC>GGT	p.G1510G		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1510	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6																		---	---	---	---
SMG1	23049	broad.mit.edu	37	16	18844443	18844443	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:18844443G>A	uc002dfm.2	-	51	8974	c.8611C>T	c.(8611-8613)CGA>TGA	p.R2871*	SMG1_uc010bwb.2_Nonsense_Mutation_p.R2731*|SMG1_uc010bwa.2_Nonsense_Mutation_p.R1602*	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2871					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16																		---	---	---	---
UMOD	7369	broad.mit.edu	37	16	20359844	20359844	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:20359844G>A	uc002dgz.2	-	3	908	c.779C>T	c.(778-780)GCG>GTG	p.A260V	UMOD_uc002dha.2_Missense_Mutation_p.A260V|UMOD_uc002dhb.2_Missense_Mutation_p.A293V	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	260					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2																		---	---	---	---
DNAH3	55567	broad.mit.edu	37	16	21147803	21147803	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21147803C>T	uc010vbe.1	-	6	728	c.728G>A	c.(727-729)CGC>CAC	p.R243H	DNAH3_uc002die.2_Missense_Mutation_p.R214H	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	243	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)														---	---	---	---
NCRNA00169	400508	broad.mit.edu	37	16	21328281	21328281	+	RNA	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:21328281C>T	uc010bwr.1	+	3		c.673C>T				NR_026675				Homo sapiens cDNA FLJ41766 fis, clone IMR322006222.											central_nervous_system(1)	1																		---	---	---	---
EEF2K	29904	broad.mit.edu	37	16	22237143	22237143	+	Silent	SNP	C	T	T	rs148266060		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:22237143C>T	uc002dki.2	+	2	578	c.93C>T	c.(91-93)AGC>AGT	p.S31S	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	31					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)														---	---	---	---
TNRC6A	27327	broad.mit.edu	37	16	24788506	24788506	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:24788506G>T	uc002dmm.2	+	5	530	c.416G>T	c.(415-417)CGA>CTA	p.R139L	TNRC6A_uc010bxs.2_5'UTR	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	139					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)														---	---	---	---
TUFM	7284	broad.mit.edu	37	16	28855078	28855078	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28855078C>A	uc002drh.2	-	9	1312	c.1173G>T	c.(1171-1173)CGG>CGT	p.R391R	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	388						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1																		---	---	---	---
SH2B1	25970	broad.mit.edu	37	16	28883542	28883542	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28883542C>T	uc002dri.2	+	9	1984	c.1545C>T	c.(1543-1545)GGC>GGT	p.G515G	uc010vct.1_Intron|SH2B1_uc010vdc.1_Silent_p.G205G|SH2B1_uc002drj.2_Silent_p.G515G|SH2B1_uc002drk.2_Silent_p.G515G|SH2B1_uc002drl.2_Silent_p.G515G|SH2B1_uc010vdd.1_Silent_p.G179G|SH2B1_uc010vde.1_Silent_p.G515G|SH2B1_uc002drm.2_Silent_p.G515G	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	515	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2																		---	---	---	---
RABEP2	79874	broad.mit.edu	37	16	28919999	28919999	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:28919999C>T	uc002drq.2	-	8	1224	c.1176G>A	c.(1174-1176)CTG>CTA	p.L392L	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.L321L|RABEP2_uc010byn.2_Silent_p.L360L	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	392	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3																		---	---	---	---
PRRT2	112476	broad.mit.edu	37	16	29825015	29825015	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:29825015G>C	uc002due.3	+	2	941	c.640G>C	c.(640-642)GCC>CCC	p.A214P	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.A214P|PRRT2_uc002duf.1_Missense_Mutation_p.A214P|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	214	Extracellular (Potential).|Pro-rich.			A -> AP (in Ref. 3; CAD38881).	response to biotic stimulus	integral to membrane					0																		---	---	---	---
SRCAP	10847	broad.mit.edu	37	16	30740479	30740479	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30740479T>C	uc002dze.1	+	26	6236	c.5851T>C	c.(5851-5853)TAT>CAT	p.Y1951H	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.Y1746H	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1951					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)															---	---	---	---
BCL7C	9274	broad.mit.edu	37	16	30904559	30904559	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:30904559C>T	uc002dzv.2	-	2	279	c.145G>A	c.(145-147)GTG>ATG	p.V49M	BCL7C_uc002dzt.1_Missense_Mutation_p.V49M|uc002dzu.2_Intron|MIR762_hsa-mir-762|MI0003892_5'Flank	NM_004765	NP_004756	Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	49					apoptosis						0			Colorectal(24;0.198)															---	---	---	---
MYST1	84148	broad.mit.edu	37	16	31138547	31138547	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:31138547G>A	uc002eay.2	+	5	572	c.554G>A	c.(553-555)GGG>GAG	p.G185E	MYST1_uc002eax.2_Missense_Mutation_p.G185E|MYST1_uc002eaz.2_Missense_Mutation_p.G27E|MYST1_uc002eba.2_5'UTR|MYST1_uc002ebb.2_5'Flank	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	185					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1																		---	---	---	---
Unknown	0	broad.mit.edu	37	16	33020732	33020732	+	IGR	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:33020732C>A								SLC6A10P (124269 upstream) : MIR1826 (944776 downstream)																																			---	---	---	---
LONP2	83752	broad.mit.edu	37	16	48385596	48385596	+	Silent	SNP	C	T	T	rs150743514		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:48385596C>T	uc002efi.1	+	15	2531	c.2442C>T	c.(2440-2442)AAC>AAT	p.N814N	LONP2_uc002efj.1_Silent_p.N770N	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	814					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0																		---	---	---	---
ZNF423	23090	broad.mit.edu	37	16	49671411	49671411	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49671411G>T	uc002efs.2	-	5	1950	c.1652C>A	c.(1651-1653)CCG>CAG	p.P551Q	ZNF423_uc010vgn.1_Missense_Mutation_p.P434Q	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	551					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)																---	---	---	---
ZNF423	23090	broad.mit.edu	37	16	49671517	49671517	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:49671517C>T	uc002efs.2	-	5	1844	c.1546G>A	c.(1546-1548)GCT>ACT	p.A516T	ZNF423_uc010vgn.1_Missense_Mutation_p.A399T	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	516					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)																---	---	---	---
HEATR3	55027	broad.mit.edu	37	16	50109581	50109581	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50109581T>C	uc002efw.2	+	6	884	c.722T>C	c.(721-723)GTC>GCC	p.V241A	HEATR3_uc002efx.2_Missense_Mutation_p.V155A	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	241							binding			ovary(1)|skin(1)	2																		---	---	---	---
PAPD5	64282	broad.mit.edu	37	16	50259111	50259111	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50259111C>T	uc010vgo.1	+	11	1705	c.1670C>T	c.(1669-1671)TCG>TTG	p.S557L	PAPD5_uc010cbi.2_RNA|PAPD5_uc002efz.2_Intron|PAPD5_uc002ega.2_Missense_Mutation_p.S348L	NM_001040284	NP_001035374	Q8NDF8	PAPD5_HUMAN	PAP associated domain containing 5 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell division|DNA replication|histone mRNA catabolic process|mitosis	cytoplasm|nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding				0		all_cancers(37;0.0452)		BRCA - Breast invasive adenocarcinoma(181;0.0843)|GBM - Glioblastoma multiforme(240;0.231)														---	---	---	---
NOD2	64127	broad.mit.edu	37	16	50746063	50746063	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50746063C>T	uc002egm.1	+	4	2346	c.2241C>T	c.(2239-2241)TAC>TAT	p.Y747Y	NOD2_uc010cbk.1_Silent_p.Y720Y|NOD2_uc002egl.1_Silent_p.Y525Y|NOD2_uc010cbl.1_Silent_p.Y525Y|NOD2_uc010cbm.1_Silent_p.Y525Y|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	747					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)																---	---	---	---
CYLD	1540	broad.mit.edu	37	16	50811786	50811786	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:50811786T>G	uc002egp.1	+	8	1487	c.1072T>G	c.(1072-1074)TTA>GTA	p.L358V	CYLD_uc002egn.1_Missense_Mutation_p.L355V|CYLD_uc002ego.2_Missense_Mutation_p.L355V|CYLD_uc010cbs.1_Missense_Mutation_p.L355V|CYLD_uc002egq.1_Missense_Mutation_p.L355V|CYLD_uc002egr.1_Missense_Mutation_p.L355V|CYLD_uc002egs.1_Missense_Mutation_p.L355V	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	358	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)						Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				---	---	---	---
CDH5	1003	broad.mit.edu	37	16	66413312	66413312	+	Silent	SNP	A	G	G	rs147924693	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:66413312A>G	uc002eom.3	+	2	228	c.72A>G	c.(70-72)GCA>GCG	p.A24A	CDH5_uc002eon.1_Silent_p.A24A	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	24					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)														---	---	---	---
KCTD19	146212	broad.mit.edu	37	16	67323574	67323574	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67323574G>T	uc002esu.2	-	16	2730	c.2679C>A	c.(2677-2679)CCC>CCA	p.P893P	KCTD19_uc002est.2_Silent_p.P665P|KCTD19_uc010vjj.1_Silent_p.P636P	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	893						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)														---	---	---	---
GFOD2	81577	broad.mit.edu	37	16	67709578	67709578	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67709578C>T	uc002eub.2	-	3	933	c.638G>A	c.(637-639)GGC>GAC	p.G213D	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.G108D	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	213						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)														---	---	---	---
CENPT	80152	broad.mit.edu	37	16	67862729	67862729	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:67862729G>A	uc002eun.3	-	14	1847	c.1298C>T	c.(1297-1299)GCA>GTA	p.A433V	CENPT_uc002eum.3_Missense_Mutation_p.A378V|CENPT_uc010vkc.1_Missense_Mutation_p.A191V|CENPT_uc010vkd.1_Missense_Mutation_p.A186V	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	433					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)														---	---	---	---
CDH1	999	broad.mit.edu	37	16	68862192	68862192	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:68862192C>T	uc002ewg.1	+	14	2404	c.2280C>T	c.(2278-2280)GGC>GGT	p.G760G	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Silent_p.G699G	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	760	Cytoplasmic (Potential).|Required for binding CTNND1 and PSEN1.			GGG->AAA: Binds to CTNNB1 but abolishes interaction of CTNNB1 with PSEN1. Abolishes gamma-secretase cleavage.	adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)				Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				---	---	---	---
VAC14	55697	broad.mit.edu	37	16	70726786	70726786	+	Silent	SNP	G	A	A	rs140883176		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70726786G>A	uc002ezm.2	-	18	2382	c.2124C>T	c.(2122-2124)AGC>AGT	p.S708S	VAC14_uc010cfw.2_Silent_p.S474S|VAC14_uc002ezn.2_Silent_p.S273S|VAC14_uc002ezo.1_5'Flank|VAC14_uc002ezl.2_Silent_p.S140S	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	708					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)																---	---	---	---
VAC14	55697	broad.mit.edu	37	16	70815824	70815824	+	Silent	SNP	G	A	A	rs142446813		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:70815824G>A	uc002ezm.2	-	8	1152	c.894C>T	c.(892-894)TCC>TCT	p.S298S	VAC14_uc010cfw.2_Silent_p.S64S|VAC14_uc002ezn.2_Intron	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	298					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)																---	---	---	---
MARVELD3	91862	broad.mit.edu	37	16	71674425	71674425	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71674425C>T	uc002fau.2	+	3	791	c.728C>T	c.(727-729)CCG>CTG	p.P243L	PHLPP2_uc002fav.2_RNA|MARVELD3_uc010cge.2_3'UTR	NM_001017967	NP_001017967	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane				skin(1)	1		Ovarian(137;0.125)																---	---	---	---
PHLPP2	23035	broad.mit.edu	37	16	71736615	71736615	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:71736615G>A	uc002fax.2	-	2	310	c.304C>T	c.(304-306)CGA>TGA	p.R102*	PHLPP2_uc010cgf.2_Nonsense_Mutation_p.R102*|PHLPP2_uc002fay.1_Nonsense_Mutation_p.R102*	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	102						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2																		---	---	---	---
DHODH	1723	broad.mit.edu	37	16	72046132	72046132	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72046132C>T	uc002fbp.2	+	2	226	c.205C>T	c.(205-207)CGG>TGG	p.R69W	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	69	Mitochondrial intermembrane (By similarity).				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)													---	---	---	---
DHX38	9785	broad.mit.edu	37	16	72130091	72130091	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72130091G>A	uc002fcb.2	+	2	390	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	TXNL4B_uc010cgl.2_5'Flank|TXNL4B_uc002fca.2_5'Flank|TXNL4B_uc010vmn.1_5'Flank|TXNL4B_uc010vmo.1_5'Flank|DHX38_uc010vmp.1_Missense_Mutation_p.R12Q|DHX38_uc010cgn.1_5'Flank	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	12					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)																---	---	---	---
DHX38	9785	broad.mit.edu	37	16	72134477	72134477	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72134477G>A	uc002fcb.2	+	9	1614	c.1259G>A	c.(1258-1260)CGC>CAC	p.R420H	DHX38_uc010vmp.1_Intron|DHX38_uc010cgn.1_RNA	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	420					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)																---	---	---	---
PMFBP1	83449	broad.mit.edu	37	16	72153907	72153907	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72153907G>A	uc002fcc.3	-	20	3037	c.2865C>T	c.(2863-2865)GCC>GCT	p.A955A	PMFBP1_uc002fcd.2_Silent_p.A950A|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.A825A	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	955	Potential.									ovary(2)	2		Ovarian(137;0.179)																---	---	---	---
PMFBP1	83449	broad.mit.edu	37	16	72173177	72173177	+	Intron	SNP	A	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:72173177A>T	uc002fcc.3	-						PMFBP1_uc002fcd.2_Intron|PMFBP1_uc002fce.2_Intron|PMFBP1_uc002fcf.2_Intron	NM_031293	NP_112583			polyamine modulated factor 1 binding protein 1											ovary(2)	2		Ovarian(137;0.179)																---	---	---	---
GLG1	2734	broad.mit.edu	37	16	74526881	74526881	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:74526881A>G	uc002fcy.3	-	7	1258	c.1208T>C	c.(1207-1209)ATG>ACG	p.M403T	GLG1_uc002fcx.2_Missense_Mutation_p.M403T|GLG1_uc002fcw.3_Missense_Mutation_p.M392T|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	403	Cys-rich GLG1 5.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2																		---	---	---	---
WDR59	79726	broad.mit.edu	37	16	74937943	74937943	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:74937943G>A	uc002fdh.1	-	18	1870	c.1768C>T	c.(1768-1770)CGC>TGC	p.R590C	WDR59_uc002fdf.1_Missense_Mutation_p.R35C|WDR59_uc002fdg.1_Missense_Mutation_p.R182C	NM_030581	NP_085058	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	590										ovary(1)|breast(1)	2																		---	---	---	---
CHST6	4166	broad.mit.edu	37	16	75512783	75512783	+	Missense_Mutation	SNP	C	T	T	rs140618049	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75512783C>T	uc002fef.2	-	3	1124	c.944G>A	c.(943-945)CGC>CAC	p.R315H	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Missense_Mutation_p.R315H	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	315	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0																		---	---	---	---
CHST5	23563	broad.mit.edu	37	16	75564134	75564134	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:75564134C>T	uc002fei.2	-	3	1544	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	CHST5_uc002fej.1_Missense_Mutation_p.R56Q	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	50	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0																		---	---	---	---
MAF	4094	broad.mit.edu	37	16	79632668	79632668	+	3'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:79632668C>T	uc002ffn.2	-	1					MAF_uc002ffm.2_Intron	NM_001031804	NP_001026974			v-maf musculoaponeurotic fibrosarcoma oncogene						transcription from RNA polymerase II promoter	chromatin|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_epithelial(2;0.139)|Lung NSC(2;0.186)|Melanoma(2;0.211)		UCEC - Uterine corpus endometrioid carcinoma (2;0.0178)				T	IGH@	MM								---	---	---	---
CDYL2	124359	broad.mit.edu	37	16	80654764	80654764	+	Silent	SNP	G	A	A	rs141862110	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:80654764G>A	uc002ffs.2	-	4	1008	c.903C>T	c.(901-903)AGC>AGT	p.S301S		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	301						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1																		---	---	---	---
GCSH	2653	broad.mit.edu	37	16	81124283	81124283	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81124283G>A	uc002fgd.2	-	2	248	c.151C>T	c.(151-153)CGT>TGT	p.R51C	GCSH_uc002fge.2_RNA	NM_004483	NP_004474	P23434	GCSH_HUMAN	glycine cleavage system protein H (aminomethyl	51						glycine cleavage complex|mitochondrion	aminomethyltransferase activity				0					Glycine(DB00145)													---	---	---	---
PKD1L2	114780	broad.mit.edu	37	16	81145839	81145839	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81145839G>A	uc002fgh.1	-	42	6913	c.6913C>T	c.(6913-6915)CGC>TGC	p.R2305C	PKD1L2_uc002fgf.1_Missense_Mutation_p.R105C|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	2305	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3																		---	---	---	---
CMIP	80790	broad.mit.edu	37	16	81694495	81694495	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:81694495G>A	uc002fgp.2	+	6	760	c.688G>A	c.(688-690)GCT>ACT	p.A230T	CMIP_uc002fgq.1_Missense_Mutation_p.A136T|CMIP_uc010vnq.1_Missense_Mutation_p.A43T|CMIP_uc002fgr.1_Missense_Mutation_p.A77T	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	196						cytoplasm|nucleus					0																		---	---	---	---
KCNG4	93107	broad.mit.edu	37	16	84256361	84256361	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84256361G>A	uc010voc.1	-	3	1143	c.1022C>T	c.(1021-1023)GCG>GTG	p.A341V		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	341	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3																		---	---	---	---
USP10	9100	broad.mit.edu	37	16	84812581	84812581	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:84812581C>T	uc002fii.2	+	14	2432	c.2290C>T	c.(2290-2292)CGC>TGC	p.R764C	USP10_uc010voe.1_Missense_Mutation_p.R768C|USP10_uc010vof.1_Missense_Mutation_p.R326C|USP10_uc002fij.2_Missense_Mutation_p.R290C	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	764					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0																		---	---	---	---
ZDHHC7	55625	broad.mit.edu	37	16	85024123	85024123	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85024123G>A	uc002fiq.2	-	3	455	c.102C>T	c.(100-102)GAC>GAT	p.D34D	ZDHHC7_uc010voi.1_Silent_p.D34D|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	34						integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1																		---	---	---	---
FAM92B	339145	broad.mit.edu	37	16	85143874	85143874	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85143874G>A	uc010vok.1	-	2	369	c.213C>T	c.(211-213)TTC>TTT	p.F71F		NM_198491	NP_940893	Q6ZTR7	FA92B_HUMAN	hypothetical protein LOC339145	71										central_nervous_system(1)	1																		---	---	---	---
COX4I1	1327	broad.mit.edu	37	16	85839437	85839437	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:85839437A>G	uc002fje.2	+	4	504	c.340A>G	c.(340-342)ACC>GCC	p.T114A	COX4I1_uc002fjf.2_3'UTR|COX4I1_uc002fjg.1_Missense_Mutation_p.T114A|COX4I1_uc010vom.1_Missense_Mutation_p.T81A	NM_001861	NP_001852	P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	114					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			lung(1)	1		Renal(780;0.228)																---	---	---	---
MTHFSD	64779	broad.mit.edu	37	16	86575426	86575426	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:86575426G>A	uc002fjn.2	-	7	609	c.558C>T	c.(556-558)GTC>GTT	p.V186V	MTHFSD_uc010voo.1_Silent_p.V166V|MTHFSD_uc002fjo.2_Silent_p.V23V|MTHFSD_uc002fjm.2_Silent_p.V185V|MTHFSD_uc010vop.1_Silent_p.V23V|MTHFSD_uc010voq.1_Silent_p.V185V|MTHFSD_uc010vor.1_Silent_p.V186V|MTHFSD_uc002fjp.2_Silent_p.V166V	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	186					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0																		---	---	---	---
CA5A	763	broad.mit.edu	37	16	87925398	87925398	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:87925398G>A	uc002fkn.1	-							NM_001739	NP_001730			carbonic anhydrase VA, mitochondrial precursor						one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)														---	---	---	---
CDH15	1013	broad.mit.edu	37	16	89257891	89257891	+	Intron	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89257891C>G	uc002fmt.2	+							NM_004933	NP_004924			cadherin 15 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)														---	---	---	---
SPG7	6687	broad.mit.edu	37	16	89614500	89614500	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr16:89614500G>A	uc002fnj.2	+	12	1663	c.1642G>A	c.(1642-1644)GCC>ACC	p.A548T	SPG7_uc002fnk.1_RNA|SPG7_uc002fnl.2_5'Flank	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	548	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)														---	---	---	---
NXN	64359	broad.mit.edu	37	17	707017	707017	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:707017C>T	uc002fsa.2	-	7	1122	c.1030G>A	c.(1030-1032)GCC>ACC	p.A344T	NXN_uc010vqd.1_Missense_Mutation_p.A35T|NXN_uc002frz.2_Missense_Mutation_p.A95T|NXN_uc010vqe.1_Missense_Mutation_p.A236T	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	344					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)														---	---	---	---
NXN	64359	broad.mit.edu	37	17	708439	708439	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:708439C>T	uc002fsa.2	-	6	961	c.869G>A	c.(868-870)CGG>CAG	p.R290Q	NXN_uc010vqd.1_Intron|NXN_uc002frz.2_Missense_Mutation_p.R41Q|NXN_uc010vqe.1_Missense_Mutation_p.R182Q	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	290	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)														---	---	---	---
WDR81	124997	broad.mit.edu	37	17	1637358	1637358	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1637358C>T	uc002fti.2	+	7	1607	c.1346C>T	c.(1345-1347)CCG>CTG	p.P449L	WDR81_uc002fth.2_Missense_Mutation_p.P625L|WDR81_uc010vqp.1_Missense_Mutation_p.P473L|WDR81_uc002ftj.2_Missense_Mutation_p.P1676L|WDR81_uc010vqq.1_Missense_Mutation_p.P307L	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	449										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)														---	---	---	---
SERPINF2	5345	broad.mit.edu	37	17	1650347	1650347	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1650347G>T	uc002ftk.1	+	6	479	c.402G>T	c.(400-402)CAG>CAT	p.Q134H	SERPINF2_uc010vqr.1_Missense_Mutation_p.Q70H	NM_000934	NP_000925	P08697	A2AP_HUMAN	alpha-2-antiplasmin isoform a precursor	134					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity				0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)													---	---	---	---
SMG6	23293	broad.mit.edu	37	17	1989031	1989031	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:1989031T>C	uc002fub.1	-	14	3577	c.3522A>G	c.(3520-3522)CGA>CGG	p.R1174R	SMG6_uc010vqv.1_Silent_p.R266R	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	1174					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4																		---	---	---	---
TSR1	55720	broad.mit.edu	37	17	2238058	2238058	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2238058C>A	uc002fuj.2	-	5	1646	c.689G>T	c.(688-690)GGG>GTG	p.G230V	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	230					ribosome assembly	nucleolus	protein binding			ovary(1)	1																		---	---	---	---
PAFAH1B1	5048	broad.mit.edu	37	17	2570463	2570463	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2570463G>A	uc002fuw.3	+	5	938	c.370G>A	c.(370-372)GTC>ATC	p.V124I	PAFAH1B1_uc010ckb.1_RNA|PAFAH1B1_uc010vqz.1_5'Flank	NM_000430	NP_000421	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase,	124	WD 1.|Interaction with dynein and dynactin.				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			skin(1)	1																		---	---	---	---
RAP1GAP2	23108	broad.mit.edu	37	17	2808601	2808601	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:2808601C>T	uc010ckd.2	+	3	194	c.104C>T	c.(103-105)TCG>TTG	p.S35L	RAP1GAP2_uc010cke.2_Missense_Mutation_p.S35L	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	35					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1																		---	---	---	---
TMEM93	83460	broad.mit.edu	37	17	3572580	3572580	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:3572580C>T	uc002fwf.1	+	2	293	c.140C>T	c.(139-141)ACC>ATC	p.T47I	TAX1BP3_uc002fwc.2_5'Flank|P2RX5_uc002fwd.2_RNA|TAX1BP3_uc002fwe.1_5'Flank|TMEM93_uc002fwg.1_Missense_Mutation_p.T47I|P2RX5_uc002fwh.1_3'UTR	NM_031298	NP_112588	Q9BV81	TMM93_HUMAN	transmembrane protein 93	47						integral to membrane					0																		---	---	---	---
SMTNL2	342527	broad.mit.edu	37	17	4496330	4496330	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4496330G>A	uc002fyf.1	+	3	661	c.594G>A	c.(592-594)ACG>ACA	p.T198T	SMTNL2_uc002fye.2_Silent_p.T54T	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	198											0				READ - Rectum adenocarcinoma(115;0.0325)														---	---	---	---
CAMTA2	23125	broad.mit.edu	37	17	4883674	4883674	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:4883674G>A	uc002gah.1	-	9	1051	c.943C>T	c.(943-945)CGA>TGA	p.R315*	CAMTA2_uc010cku.1_Nonsense_Mutation_p.R338*|CAMTA2_uc002gag.1_Nonsense_Mutation_p.R314*|CAMTA2_uc002gai.1_Nonsense_Mutation_p.R317*|CAMTA2_uc010ckv.1_5'UTR|CAMTA2_uc010vsu.1_Nonsense_Mutation_p.R128*	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	315					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1																OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
USP6	9098	broad.mit.edu	37	17	5073913	5073913	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5073913A>G	uc002gau.1	+	36	5887	c.3657A>G	c.(3655-3657)TCA>TCG	p.S1219S	USP6_uc002gav.1_Silent_p.S1219S|USP6_uc010ckz.1_Silent_p.S902S	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	1219					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5								T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								---	---	---	---
NLRP1	22861	broad.mit.edu	37	17	5425092	5425092	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:5425092T>C	uc002gci.2	-	13	4090	c.3535A>G	c.(3535-3537)ACA>GCA	p.T1179A	NLRP1_uc002gcg.1_Missense_Mutation_p.T1183A|NLRP1_uc002gck.2_Missense_Mutation_p.T1179A|NLRP1_uc002gcj.2_Missense_Mutation_p.T1149A|NLRP1_uc002gcl.2_Missense_Mutation_p.T1149A|NLRP1_uc002gch.3_Missense_Mutation_p.T1179A	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1179					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)																---	---	---	---
NEURL4	84461	broad.mit.edu	37	17	7219602	7219602	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7219602G>A	uc002gga.1	-	29	4536	c.4529C>T	c.(4528-4530)GCG>GTG	p.A1510V	GPS2_uc002gfv.1_5'Flank|GPS2_uc002gfw.1_5'Flank|GPS2_uc002gfx.1_5'Flank|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_5'UTR|NEURL4_uc002ggb.1_Missense_Mutation_p.A1508V	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	1510							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2																		---	---	---	---
C17orf74	201243	broad.mit.edu	37	17	7330257	7330257	+	Missense_Mutation	SNP	G	A	A	rs117934604	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7330257G>A	uc002ggw.2	+	3	1020	c.947G>A	c.(946-948)CGT>CAT	p.R316H	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	316						integral to membrane					0		Prostate(122;0.157)																---	---	---	---
POLR2A	5430	broad.mit.edu	37	17	7405890	7405890	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7405890G>A	uc002ghf.3	+	16	2860	c.2626G>A	c.(2626-2628)GAC>AAC	p.D876N		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	876					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)																---	---	---	---
KCNAB3	9196	broad.mit.edu	37	17	7829035	7829035	+	Silent	SNP	G	A	A	rs147020421		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7829035G>A	uc002gjm.1	-	7	504	c.504C>T	c.(502-504)ACC>ACT	p.T168T	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	168						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)																---	---	---	---
GUCY2D	3000	broad.mit.edu	37	17	7917940	7917940	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7917940C>T	uc002gjt.2	+	13	2508	c.2434C>T	c.(2434-2436)CGG>TGG	p.R812W		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	812	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)																---	---	---	---
GUCY2D	3000	broad.mit.edu	37	17	7919132	7919132	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:7919132G>A	uc002gjt.2	+	16	3090	c.3016G>A	c.(3016-3018)GCC>ACC	p.A1006T		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	1006	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)																---	---	---	---
ALOXE3	59344	broad.mit.edu	37	17	8012480	8012480	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8012480C>T	uc010cnr.2	-						ALOXE3_uc002gka.2_Intron|ALOXE3_uc010vuo.1_Intron	NM_021628	NP_067641			arachidonate lipoxygenase 3 isoform 2						leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5																		---	---	---	---
RANGRF	29098	broad.mit.edu	37	17	8192692	8192692	+	Missense_Mutation	SNP	T	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:8192692T>A	uc002gkv.2	+	3	429	c.311T>A	c.(310-312)GTC>GAC	p.V104D	SLC25A35_uc002gku.1_3'UTR|SLC25A35_uc002gkt.2_Intron|RANGRF_uc002gkw.2_Missense_Mutation_p.V104D|RANGRF_uc002gky.2_Missense_Mutation_p.V104D|RANGRF_uc002gkx.2_Missense_Mutation_p.V104D|SLC25A35_uc002gkz.1_RNA	NM_016492	NP_057576	Q9HD47	MOG1_HUMAN	RAN guanine nucleotide release factor	104					protein transport	cytoplasm|nucleus	guanyl-nucleotide exchange factor activity				0																		---	---	---	---
USP43	124739	broad.mit.edu	37	17	9596520	9596520	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9596520G>A	uc010cod.2	+	9	1430	c.1430G>A	c.(1429-1431)CGG>CAG	p.R477Q	USP43_uc002gma.3_Missense_Mutation_p.R166Q|USP43_uc010vva.1_Missense_Mutation_p.R477Q|USP43_uc010coe.2_Missense_Mutation_p.R274Q	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	477					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5																		---	---	---	---
GAS7	8522	broad.mit.edu	37	17	9846445	9846445	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:9846445G>A	uc002gmg.1	-	7	885	c.724C>T	c.(724-726)CGG>TGG	p.R242W	GAS7_uc010vvc.1_Missense_Mutation_p.R56W|GAS7_uc002gmh.1_Missense_Mutation_p.R102W|GAS7_uc010vvd.1_Missense_Mutation_p.R194W|GAS7_uc002gmi.2_Missense_Mutation_p.R178W|GAS7_uc002gmj.1_Missense_Mutation_p.R182W|GAS7_uc010coh.1_Missense_Mutation_p.R182W	NM_201433	NP_958839	O60861	GAS7_HUMAN	growth arrest-specific 7 isoform c	242	FCH.				cell cycle arrest	cytoplasm	sequence-specific DNA binding transcription factor activity			lung(1)|pancreas(1)	2								T	MLL	AML*								---	---	---	---
PMP22	5376	broad.mit.edu	37	17	15162426	15162426	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:15162426A>G	uc002goj.2	-	2	212	c.163T>C	c.(163-165)TCA>CCA	p.S55P	PMP22_uc002gok.2_Missense_Mutation_p.S55P|PMP22_uc002gol.2_Missense_Mutation_p.S55P	NM_153322	NP_696997	Q01453	PMP22_HUMAN	peripheral myelin protein 22	55					peripheral nervous system development|synaptic transmission	integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0884)|BRCA - Breast invasive adenocarcinoma(8;4.92e-06)														---	---	---	---
RAI1	10743	broad.mit.edu	37	17	17697948	17697948	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:17697948C>T	uc002grm.2	+	3	2155	c.1686C>T	c.(1684-1686)GAC>GAT	p.D562D	RAI1_uc002grn.1_Silent_p.D562D	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	562						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)														---	---	---	---
MYO15A	51168	broad.mit.edu	37	17	18022933	18022933	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18022933C>A	uc010vxh.1	+	2	1157	c.819C>A	c.(817-819)CCC>CCA	p.P273P		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	273	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)																	---	---	---	---
FLII	2314	broad.mit.edu	37	17	18154602	18154602	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18154602C>T	uc002gsr.1	-	13	1624	c.1573G>A	c.(1573-1575)GCT>ACT	p.A525T	FLII_uc002gsq.1_Missense_Mutation_p.A396T|FLII_uc010cpy.1_Missense_Mutation_p.A514T|FLII_uc010vxn.1_Missense_Mutation_p.A494T|FLII_uc010vxo.1_Missense_Mutation_p.A470T|FLII_uc002gss.1_Missense_Mutation_p.A524T	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	525	Interaction with ACTL6A.|Gelsolin-like 1.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)																	---	---	---	---
TRIM16L	147166	broad.mit.edu	37	17	18631016	18631016	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18631016G>T	uc002gug.1	+	7	833	c.146G>T	c.(145-147)AGT>ATT	p.S49I	TRIM16L_uc010vyf.1_Missense_Mutation_p.S103I|TRIM16L_uc002guh.1_Missense_Mutation_p.S49I|TRIM16L_uc010cqg.1_Missense_Mutation_p.S151I|TRIM16L_uc002gui.1_Missense_Mutation_p.S49I|TRIM16L_uc010vyg.1_Missense_Mutation_p.S49I|TRIM16L_uc010vyh.1_Missense_Mutation_p.S49I	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	49						cytoplasm					0																		---	---	---	---
FAM18B	51030	broad.mit.edu	37	17	18707468	18707468	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:18707468T>C	uc002gum.2	+	6	505	c.480T>C	c.(478-480)GGT>GGC	p.G160G	FAM18B_uc002gun.2_Silent_p.G96G	NM_016078	NP_057162	Q9NYZ1	F18B1_HUMAN	hypothetical protein LOC51030	160	Helical; (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (53;0.0872)|READ - Rectum adenocarcinoma(1115;0.0967)														---	---	---	---
CYTSB	92521	broad.mit.edu	37	17	20108291	20108291	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:20108291G>A	uc002gwq.2	+	4	1074	c.929G>A	c.(928-930)CGG>CAG	p.R310Q	CYTSB_uc010cqx.2_Missense_Mutation_p.R310Q|CYTSB_uc002gwr.2_Missense_Mutation_p.R310Q|CYTSB_uc002gws.2_Missense_Mutation_p.R310Q|CYTSB_uc002gwv.2_Missense_Mutation_p.R229Q|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.R86Q|CYTSB_uc002gwt.2_Missense_Mutation_p.R229Q|CYTSB_uc002gwu.2_Missense_Mutation_p.R229Q	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	310	Ser-rich.					nucleus					0																		---	---	---	---
TMEM11	8834	broad.mit.edu	37	17	21101945	21101945	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:21101945C>T	uc002gyp.2	-	2	714	c.271G>A	c.(271-273)GCC>ACC	p.A91T	TMEM11_uc002gyq.2_3'UTR	NM_003876	NP_003867	P17152	TMM11_HUMAN	transmembrane protein 11	91	Helical; (Potential).				mitochondrion organization	integral to mitochondrial inner membrane|integral to plasma membrane	protein binding				0																		---	---	---	---
VTN	7448	broad.mit.edu	37	17	26694831	26694831	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26694831C>T	uc002hbc.2	-	7	1378	c.1229G>A	c.(1228-1230)AGC>AAC	p.S410N	SARM1_uc010wah.1_Intron|SEBOX_uc010wai.1_5'Flank|SEBOX_uc010crk.1_5'UTR|SARM1_uc010waj.1_Intron	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	410					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)													---	---	---	---
PIGS	94005	broad.mit.edu	37	17	26883896	26883896	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26883896G>A	uc002hbo.2	-	9	1402	c.1029C>T	c.(1027-1029)GGC>GGT	p.G343G	PIGS_uc002hbn.2_Silent_p.G335G|PIGS_uc010wap.1_Silent_p.G282G	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	343	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)																	---	---	---	---
ALDOC	230	broad.mit.edu	37	17	26901099	26901099	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:26901099G>T	uc002hbp.2	-	7	930	c.785C>A	c.(784-786)CCC>CAC	p.P262H	PIGS_uc002hbn.2_5'Flank|PIGS_uc002hbo.2_5'Flank|PIGS_uc010wap.1_5'Flank|ALDOC_uc010cro.2_Missense_Mutation_p.P234H	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	262					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)																	---	---	---	---
MYO18A	399687	broad.mit.edu	37	17	27446378	27446378	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:27446378G>A	uc002hdt.1	-	8	1962	c.1804C>T	c.(1804-1806)CTG>TTG	p.L602L	MYO18A_uc010wbc.1_Silent_p.L144L|MYO18A_uc002hds.2_Silent_p.L144L|MYO18A_uc010csa.1_Silent_p.L602L|MYO18A_uc002hdu.1_Silent_p.L602L|MYO18A_uc010wbd.1_Silent_p.L271L	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	602	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)															---	---	---	---
CCDC55	84081	broad.mit.edu	37	17	28511866	28511866	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:28511866G>T	uc002heu.2	+	7	879	c.851G>T	c.(850-852)AGG>ATG	p.R284M	CCDC55_uc002hev.2_Missense_Mutation_p.R230M|CCDC55_uc010wbl.1_Missense_Mutation_p.R230M|CCDC55_uc010wbm.1_Missense_Mutation_p.R230M|CCDC55_uc002hex.2_Missense_Mutation_p.R230M	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	284	His-rich.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0																		---	---	---	---
MYO1D	4642	broad.mit.edu	37	17	31107788	31107788	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:31107788C>T	uc002hho.1	-	2	122	c.110G>A	c.(109-111)CGC>CAC	p.R37H	MYO1D_uc002hhp.1_Missense_Mutation_p.R37H|MYO1D_uc010wcb.1_Missense_Mutation_p.R37H	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	37	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)															---	---	---	---
CCL2	6347	broad.mit.edu	37	17	32583268	32583268	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:32583268G>A	uc002hhy.2	+	2	177	c.104G>A	c.(103-105)TGT>TAT	p.C35Y		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	35				Missing: 90% reduction in activity.|Missing: 83% reduction in activity.	angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)													---	---	---	---
AMAC1	146861	broad.mit.edu	37	17	33520747	33520747	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33520747C>T	uc002hjd.2	-	1	666	c.580G>A	c.(580-582)GTG>ATG	p.V194M		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	194	Helical; (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)														---	---	---	---
AP2B1	163	broad.mit.edu	37	17	33984642	33984642	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:33984642T>C	uc002hjr.2	+	14	2010	c.1821T>C	c.(1819-1821)GTT>GTC	p.V607V	AP2B1_uc002hjq.2_Silent_p.V607V|AP2B1_uc010wci.1_Silent_p.V569V|AP2B1_uc002hjs.2_Silent_p.V550V|AP2B1_uc002hjt.2_Silent_p.V607V|AP2B1_uc010ctv.2_Silent_p.V607V|AP2B1_uc010wcj.1_Silent_p.V344V	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	607	Pro-rich (stalk region).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)														---	---	---	---
MMP28	79148	broad.mit.edu	37	17	34100368	34100368	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34100368C>T	uc002hjy.1	-	4	679	c.420G>A	c.(418-420)GTG>GTA	p.V140V	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	140					proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)														---	---	---	---
RDM1	201299	broad.mit.edu	37	17	34249635	34249635	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:34249635C>T	uc002hkh.2	-	5	662	c.613G>A	c.(613-615)GCT>ACT	p.A205T	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Missense_Mutation_p.A182T|RDM1_uc002hkg.3_Intron|RDM1_uc010cub.2_RNA|RDM1_uc010cud.2_Intron|RDM1_uc010cuf.2_RNA|RDM1_uc010cue.2_RNA|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_3'UTR|RDM1_uc010wcp.1_Missense_Mutation_p.A182T|RDM1_uc002hki.2_Missense_Mutation_p.A205T	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	205					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)									Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
MED1	5469	broad.mit.edu	37	17	37565661	37565661	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37565661C>T	uc002hrv.3	-	17	3025	c.2813G>A	c.(2812-2814)GGC>GAC	p.G938D	MED1_uc010wee.1_Missense_Mutation_p.G766D|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	938	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)											HNSCC(31;0.082)			---	---	---	---
STARD3	10948	broad.mit.edu	37	17	37815758	37815758	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:37815758G>T	uc002hsd.2	+	9	871	c.747G>T	c.(745-747)GTG>GTT	p.V249V	STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Silent_p.V231V|STARD3_uc010wei.1_Silent_p.V249V|STARD3_uc002hsf.2_Silent_p.V115V|STARD3_uc002hsg.2_Silent_p.V82V	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	249	START.|Cytoplasmic (Potential).				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)															---	---	---	---
KRT40	125115	broad.mit.edu	37	17	39140460	39140460	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:39140460T>C	uc010cxh.1	-	3	227	c.66A>G	c.(64-66)GCA>GCG	p.A22A	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	22	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)																---	---	---	---
KLHL11	55175	broad.mit.edu	37	17	40010508	40010508	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40010508C>T	uc002hyf.1	-	2	1617	c.1611G>A	c.(1609-1611)GTG>GTA	p.V537V		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	537	Kelch 4.					extracellular region					0		Breast(137;0.00156)																---	---	---	---
DHX58	79132	broad.mit.edu	37	17	40255748	40255748	+	Silent	SNP	C	T	T	rs141850808	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40255748C>T	uc002hyw.3	-	12	1855	c.1632G>A	c.(1630-1632)CGG>CGA	p.R544R	DHX58_uc002hyv.3_Intron|DHX58_uc010wgf.1_Silent_p.R537R	NM_024119	NP_077024	Q96C10	DHX58_HUMAN	RNA helicase LGP2	544	Potential.				innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding				0		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)														---	---	---	---
PLEKHH3	79990	broad.mit.edu	37	17	40825750	40825750	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:40825750C>T	uc002iau.2	-	4	868	c.401G>A	c.(400-402)AGC>AAC	p.S134N	PLEKHH3_uc010cyl.1_5'Flank|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Missense_Mutation_p.S134N	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	134	PH.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)														---	---	---	---
MPP2	4355	broad.mit.edu	37	17	41958079	41958079	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:41958079C>T	uc010wip.1	-	10	1322	c.1265G>A	c.(1264-1266)CGC>CAC	p.R422H	MPP2_uc002ien.1_Missense_Mutation_p.R394H|MPP2_uc010wim.1_Missense_Mutation_p.R366H|MPP2_uc002ieo.1_Missense_Mutation_p.R377H|MPP2_uc010win.1_Missense_Mutation_p.R238H|MPP2_uc010wio.1_Missense_Mutation_p.R366H	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	401	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)												OREG0024443	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SLC4A1	6521	broad.mit.edu	37	17	42338116	42338116	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42338116G>A	uc002igf.3	-	5	385	c.236C>T	c.(235-237)GCG>GTG	p.A79V	SLC4A1_uc002igg.3_Missense_Mutation_p.A79V	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	79	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)														---	---	---	---
ITGA2B	3674	broad.mit.edu	37	17	42452962	42452962	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42452962G>A	uc002igt.1	-	26	2756	c.2724C>T	c.(2722-2724)CTC>CTT	p.L908L	ITGA2B_uc002igu.1_Silent_p.L389L	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	908	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)													---	---	---	---
ITGA2B	3674	broad.mit.edu	37	17	42457392	42457392	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:42457392T>C	uc002igt.1	-	17	1762	c.1730A>G	c.(1729-1731)CAC>CGC	p.H577R	ITGA2B_uc002igu.1_Missense_Mutation_p.H58R	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	577	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)													---	---	---	---
KIF18B	146909	broad.mit.edu	37	17	43005605	43005605	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43005605C>T	uc010wji.1	-	13	2175	c.2074G>A	c.(2074-2076)GTT>ATT	p.V692I	KIF18B_uc002iht.2_Missense_Mutation_p.V701I|KIF18B_uc010wjh.1_Missense_Mutation_p.V689I	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)																---	---	---	---
C1QL1	10882	broad.mit.edu	37	17	43044936	43044936	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:43044936C>T	uc002ihv.2	-	1	709	c.481G>A	c.(481-483)GCG>ACG	p.A161T		NM_006688	NP_006679	O75973	C1QRF_HUMAN	complement component 1, q subcomponent-like 1	161	C1q.				locomotory behavior	collagen					0		Prostate(33;0.155)																---	---	---	---
SP2	6668	broad.mit.edu	37	17	46002810	46002810	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:46002810G>A	uc002imk.2	+	6	1781	c.1644G>A	c.(1642-1644)CTG>CTA	p.L548L	SP2_uc002iml.2_Silent_p.L541L	NM_003110	NP_003101	Q02086	SP2_HUMAN	Sp2 transcription factor	548	C2H2-type 1.				immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding				0																		---	---	---	---
B4GALNT2	124872	broad.mit.edu	37	17	47237944	47237944	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47237944C>T	uc002ion.2	+	7	946	c.887C>T	c.(886-888)GCC>GTC	p.A296V	B4GALNT2_uc010wlt.1_Missense_Mutation_p.A210V|B4GALNT2_uc010wlu.1_Missense_Mutation_p.A236V	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	296	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)															---	---	---	---
GNGT2	2793	broad.mit.edu	37	17	47284191	47284191	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:47284191G>A	uc002ioo.1	-	4	445	c.138C>T	c.(136-138)AAC>AAT	p.N46N		NM_031498	NP_113686	O14610	GBGT2_HUMAN	guanine nucleotide binding protein-gamma	46					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)															---	---	---	---
COL1A1	1277	broad.mit.edu	37	17	48263139	48263139	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48263139C>T	uc002iqm.2	-	50	4374	c.4248G>A	c.(4246-4248)ACG>ACA	p.T1416T		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	1416	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						---	---	---	---
CACNA1G	8913	broad.mit.edu	37	17	48684339	48684339	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:48684339G>A	uc002irk.1	+	24	4873	c.4501G>A	c.(4501-4503)GTG>ATG	p.V1501M	CACNA1G_uc002irj.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irl.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irm.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irn.1_Missense_Mutation_p.V1478M|CACNA1G_uc002iro.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irp.1_Missense_Mutation_p.V1501M|CACNA1G_uc002irq.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irr.1_Missense_Mutation_p.V1501M|CACNA1G_uc002irs.1_Missense_Mutation_p.V1501M|CACNA1G_uc002irt.1_Missense_Mutation_p.V1501M|CACNA1G_uc002irv.1_Missense_Mutation_p.V1501M|CACNA1G_uc002irw.1_Missense_Mutation_p.V1478M|CACNA1G_uc002iru.1_Missense_Mutation_p.V1478M|CACNA1G_uc002irx.1_Missense_Mutation_p.V1414M|CACNA1G_uc002iry.1_Missense_Mutation_p.V1414M|CACNA1G_uc002irz.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isa.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isb.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isc.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isd.1_Missense_Mutation_p.V1414M|CACNA1G_uc002ise.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isf.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isg.1_Missense_Mutation_p.V1414M|CACNA1G_uc002ish.1_Missense_Mutation_p.V1414M|CACNA1G_uc002isi.1_Missense_Mutation_p.V1391M|CACNA1G_uc002isj.2_Missense_Mutation_p.V225M	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1501	Extracellular (Potential).|III.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)													---	---	---	---
SPAG9	9043	broad.mit.edu	37	17	49057239	49057239	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49057239G>A	uc002itc.2	-	26	3486	c.3277C>T	c.(3277-3279)CGA>TGA	p.R1093*	SPAG9_uc002itb.2_Nonsense_Mutation_p.R1079*|SPAG9_uc002itd.2_Nonsense_Mutation_p.R1083*|SPAG9_uc002ita.2_Nonsense_Mutation_p.R936*	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1093					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)															---	---	---	---
SPAG9	9043	broad.mit.edu	37	17	49067893	49067893	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:49067893A>G	uc002itc.2	-	20	2744	c.2535T>C	c.(2533-2535)GTT>GTC	p.V845V	SPAG9_uc002itb.2_Silent_p.V831V|SPAG9_uc002itd.2_Silent_p.V835V|SPAG9_uc002itf.2_Silent_p.V666V|SPAG9_uc002ita.2_Silent_p.V688V|SPAG9_uc002ite.2_Silent_p.V675V	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	845					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)															---	---	---	---
BZRAP1	9256	broad.mit.edu	37	17	56389688	56389688	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56389688G>A	uc002ivx.3	-	17	3365	c.2494C>T	c.(2494-2496)CGA>TGA	p.R832*	BZRAP1_uc010dcs.2_Nonsense_Mutation_p.R772*|BZRAP1_uc010wnt.1_Nonsense_Mutation_p.R832*	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	832	Fibronectin type-III 1.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
BZRAP1	9256	broad.mit.edu	37	17	56404939	56404939	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56404939G>A	uc002ivx.3	-						BZRAP1_uc010dcs.2_Intron|BZRAP1_uc010wnt.1_Intron|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749			peripheral benzodiazepine receptor-associated							mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
C17orf47	284083	broad.mit.edu	37	17	56620549	56620549	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:56620549G>A	uc002iwq.1	-	1	1135	c.999C>T	c.(997-999)CGC>CGT	p.R333R	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	333										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)																	---	---	---	---
DHX40	79665	broad.mit.edu	37	17	57682875	57682875	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:57682875C>T	uc002ixn.1	+	17	2187	c.2040C>T	c.(2038-2040)TAC>TAT	p.Y680Y	DHX40_uc010woe.1_Silent_p.Y603Y|DHX40_uc010wof.1_Silent_p.Y195Y	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	680							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)																	---	---	---	---
USP32	84669	broad.mit.edu	37	17	58262986	58262986	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:58262986C>A	uc002iyo.1	-	30	3955	c.3669G>T	c.(3667-3669)GAG>GAT	p.E1223D	USP32_uc002iyn.1_Missense_Mutation_p.E893D	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	1223					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)															---	---	---	---
TLK2	11011	broad.mit.edu	37	17	60637441	60637441	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60637441G>A	uc010ddp.2	+	10	1053	c.785G>A	c.(784-786)CGA>CAA	p.R262Q	TLK2_uc002izx.3_Missense_Mutation_p.R110Q|TLK2_uc002izz.3_Missense_Mutation_p.R262Q|TLK2_uc002jaa.3_Missense_Mutation_p.R230Q|TLK2_uc010wpd.1_Missense_Mutation_p.R230Q	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	262	Potential.		R -> Q.		cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2																		---	---	---	---
MRC2	9902	broad.mit.edu	37	17	60759276	60759276	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60759276C>T	uc002jad.2	+	19	3183	c.2781C>T	c.(2779-2781)TGC>TGT	p.C927C	MRC2_uc002jae.2_5'UTR|MRC2_uc002jaf.2_5'UTR	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	927	Extracellular (Potential).|C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
MARCH10	162333	broad.mit.edu	37	17	60879085	60879085	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:60879085G>A	uc010ddr.2	-	2	250	c.12C>T	c.(10-12)GAC>GAT	p.D4D	MARCH10_uc002jag.3_Silent_p.D4D|MARCH10_uc010dds.2_Silent_p.D4D|MARCH10_uc002jah.2_Silent_p.D4D	NM_001100875	NP_001094345	Q8NA82	MARHA_HUMAN	ring finger protein 190	4							ligase activity|zinc ion binding				0																		---	---	---	---
ACE	1636	broad.mit.edu	37	17	61574216	61574216	+	Silent	SNP	G	A	A	rs141429845		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:61574216G>A	uc002jau.1	+	24	3583	c.3561G>A	c.(3559-3561)ACG>ACA	p.T1187T	ACE_uc002jav.1_Silent_p.T613T|ACE_uc010ddv.1_Silent_p.T414T|ACE_uc010wpj.1_Silent_p.T572T|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Silent_p.T392T	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1187	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)													---	---	---	---
SCN4A	6329	broad.mit.edu	37	17	62041916	62041916	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62041916T>C	uc002jds.1	-	9	1441	c.1364A>G	c.(1363-1365)GAG>GGG	p.E455G		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	455					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)													---	---	---	---
ERN1	2081	broad.mit.edu	37	17	62149396	62149396	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:62149396C>T	uc002jdz.2	-	6	536	c.423G>A	c.(421-423)TCG>TCA	p.S141S		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	141	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9																		---	---	---	---
ABCA9	10350	broad.mit.edu	37	17	67018012	67018012	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:67018012G>A	uc002jhu.2	-						ABCA9_uc010dez.2_Intron	NM_080283	NP_525022			ATP-binding cassette, sub-family A, member 9						transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)																	---	---	---	---
SLC39A11	201266	broad.mit.edu	37	17	71084850	71084850	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71084850G>A	uc002jjb.2	-	2	169	c.54C>T	c.(52-54)ACC>ACT	p.T18T	SLC39A11_uc002jja.2_Silent_p.T18T|SLC39A11_uc002jjc.1_Silent_p.T18T	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	18	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1																		---	---	---	---
SDK2	54549	broad.mit.edu	37	17	71389713	71389713	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71389713C>T	uc010dfm.2	-	27	3884	c.3884G>A	c.(3883-3885)CGG>CAG	p.R1295Q	SDK2_uc002jjt.3_Missense_Mutation_p.R454Q|SDK2_uc010dfn.2_Missense_Mutation_p.R974Q	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1295	Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2																		---	---	---	---
SDK2	54549	broad.mit.edu	37	17	71427647	71427647	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:71427647C>T	uc010dfm.2	-	11	1474	c.1474G>A	c.(1474-1476)GTT>ATT	p.V492I	SDK2_uc010dfn.2_Missense_Mutation_p.V171I	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	492	Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2																		---	---	---	---
BTBD17	388419	broad.mit.edu	37	17	72356374	72356374	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:72356374G>A	uc002jkn.2	-	2	96	c.96C>T	c.(94-96)GCC>GCT	p.A32A		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	32						extracellular region					0																		---	---	---	---
KIAA0195	9772	broad.mit.edu	37	17	73487495	73487495	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73487495C>A	uc002jnz.3	+	13	1620	c.1345C>A	c.(1345-1347)CTC>ATC	p.L449I	KIAA0195_uc010wsa.1_Missense_Mutation_p.L459I|KIAA0195_uc010wsb.1_Missense_Mutation_p.L101I	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	449					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
KIAA0195	9772	broad.mit.edu	37	17	73488711	73488711	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73488711C>A	uc002jnz.3	+	15	2028	c.1753C>A	c.(1753-1755)CTG>ATG	p.L585M	KIAA0195_uc010wsa.1_Missense_Mutation_p.L595M|KIAA0195_uc010wsb.1_Missense_Mutation_p.L225M|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	585					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
RECQL5	9400	broad.mit.edu	37	17	73627305	73627305	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73627305G>A	uc010dgl.2	-	10	1629	c.1473C>T	c.(1471-1473)AGC>AGT	p.S491S	RECQL5_uc010dgk.2_Silent_p.S464S|RECQL5_uc002jot.3_5'Flank|LOC643008_uc002jow.2_5'Flank	NM_004259	NP_004250	O94762	RECQ5_HUMAN	RecQ protein-like 5 isoform 1	491					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			kidney(3)	3	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)										Other_identified_genes_with_known_or_suspected_DNA_repair_function					---	---	---	---
ITGB4	3691	broad.mit.edu	37	17	73729750	73729750	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73729750G>A	uc002jpg.2	+	13	1821	c.1634G>A	c.(1633-1635)CGC>CAC	p.R545H	ITGB4_uc002jph.2_Missense_Mutation_p.R545H|ITGB4_uc010dgo.2_Missense_Mutation_p.R545H|ITGB4_uc002jpi.3_Missense_Mutation_p.R545H|ITGB4_uc010dgp.1_Missense_Mutation_p.R545H|ITGB4_uc002jpj.2_Missense_Mutation_p.R545H|ITGB4_uc010wsh.1_Missense_Mutation_p.R100H	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	545	III.|Extracellular (Potential).|Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
UNK	85451	broad.mit.edu	37	17	73805973	73805973	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73805973C>T	uc002jpm.2	+	3	465	c.465C>T	c.(463-465)GAC>GAT	p.D155D		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	79							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
MRPL38	64978	broad.mit.edu	37	17	73895038	73895038	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:73895038G>A	uc010wso.1	-	9	1261	c.1036C>T	c.(1036-1038)CGG>TGG	p.R346W	FBF1_uc002jqa.1_RNA|TRIM65_uc002jpx.2_5'Flank|MRPL38_uc002jpz.1_RNA	NM_032478	NP_115867	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38 precursor	346						actin cytoskeleton|mitochondrion|ribosome				pancreas(1)	1			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)															---	---	---	---
EVPL	2125	broad.mit.edu	37	17	74003199	74003199	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74003199C>T	uc002jqi.2	-	22	6315	c.6087G>A	c.(6085-6087)CCG>CCA	p.P2029P	EVPL_uc010wss.1_Silent_p.P2051P|EVPL_uc010wst.1_Silent_p.P1499P	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	2029	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4																		---	---	---	---
EXOC7	23265	broad.mit.edu	37	17	74079821	74079821	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74079821C>T	uc002jqs.2	-	20	2211	c.2116G>A	c.(2116-2118)GTG>ATG	p.V706M	EXOC7_uc002jqp.1_Silent_p.A167A|EXOC7_uc010dgv.1_Missense_Mutation_p.V580M|EXOC7_uc002jqq.2_Missense_Mutation_p.V655M|EXOC7_uc010wsw.1_Missense_Mutation_p.V678M|EXOC7_uc010wsx.1_Missense_Mutation_p.V647M|EXOC7_uc002jqr.2_Missense_Mutation_p.V624M|EXOC7_uc010wsv.1_Missense_Mutation_p.V627M	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	706					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
FOXJ1	2302	broad.mit.edu	37	17	74133820	74133820	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:74133820G>A	uc002jqw.2	-	2	970	c.880C>T	c.(880-882)CCC>TCC	p.P294S	FOXJ1_uc002jqx.2_Missense_Mutation_p.P294S|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	294					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)															---	---	---	---
AZI1	22994	broad.mit.edu	37	17	79180662	79180662	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79180662G>A	uc002jzp.1	-	5	597	c.397C>T	c.(397-399)CCC>TCC	p.P133S	AZI1_uc002jzn.1_Missense_Mutation_p.P133S|AZI1_uc002jzo.1_Missense_Mutation_p.P133S|AZI1_uc010wum.1_Missense_Mutation_p.P133S	NM_014984	NP_055799	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1 isoform a	133					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				central_nervous_system(2)|large_intestine(1)|ovary(1)	4	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)															---	---	---	---
ASPSCR1	79058	broad.mit.edu	37	17	79966913	79966913	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:79966913C>T	uc002kcx.2	+	8	1031	c.934C>T	c.(934-936)CCC>TCC	p.P312S	ASPSCR1_uc002kcw.1_Missense_Mutation_p.P312S|ASPSCR1_uc002kcy.2_Missense_Mutation_p.P312S|ASPSCR1_uc002kcz.2_Missense_Mutation_p.P206S|ASPSCR1_uc002kda.2_Missense_Mutation_p.P235S|ASPSCR1_uc002kdb.1_Missense_Mutation_p.P235S	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	312		Breakpoint for translocation to form ASPSCR1-TFE3.					protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)					T	TFE3	alveolar soft part sarcoma								---	---	---	---
FASN	2194	broad.mit.edu	37	17	80049217	80049217	+	Missense_Mutation	SNP	G	A	A	rs143812680		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr17:80049217G>A	uc002kdu.2	-	9	1490	c.1373C>T	c.(1372-1374)GCG>GTG	p.A458V	FASN_uc002kdw.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	458	Acyl and malonyl transferases (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)													---	---	---	---
USP14	9097	broad.mit.edu	37	18	211172	211172	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:211172T>C	uc002kkf.1	+	16	1589	c.1373T>C	c.(1372-1374)GTA>GCA	p.V458A	USP14_uc002kkg.1_Missense_Mutation_p.V423A|USP14_uc010wyr.1_Missense_Mutation_p.V447A	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	458					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)																---	---	---	---
DLGAP1	9229	broad.mit.edu	37	18	3879562	3879562	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:3879562G>A	uc002kmf.2	-	1	574	c.507C>T	c.(505-507)AGC>AGT	p.S169S	DLGAP1_uc010wyz.1_Silent_p.S169S|DLGAP1_uc002kmk.2_Silent_p.S169S|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	169					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)																---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	6955369	6955369	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:6955369C>T	uc002knm.2	-	57	8284	c.8190G>A	c.(8188-8190)CAG>CAA	p.Q2730Q	LAMA1_uc002knk.2_Silent_p.Q60Q|LAMA1_uc002knl.2_Silent_p.Q183Q|LAMA1_uc010wzj.1_Silent_p.Q2206Q	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2730	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
LAMA1	284217	broad.mit.edu	37	18	7036056	7036056	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:7036056G>A	uc002knm.2	-	13	1863	c.1769C>T	c.(1768-1770)ACG>ATG	p.T590M	LAMA1_uc010wzj.1_Missense_Mutation_p.T66M	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	590	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
AFG3L2	10939	broad.mit.edu	37	18	12356744	12356744	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:12356744G>A	uc002kqz.1	-	9	1226	c.1113C>T	c.(1111-1113)ACC>ACT	p.T371T		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	371					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)													---	---	---	---
C18orf8	29919	broad.mit.edu	37	18	21087004	21087004	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:21087004A>G	uc010xax.1	+	3	371	c.250A>G	c.(250-252)ACC>GCC	p.T84A	C18orf8_uc010xau.1_Intron|C18orf8_uc010xav.1_Missense_Mutation_p.T84A|C18orf8_uc010xaw.1_Intron|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	84										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)																	---	---	---	---
KCTD1	284252	broad.mit.edu	37	18	24039686	24039686	+	Silent	SNP	G	A	A	rs146911358		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:24039686G>A	uc002kvw.2	-	4	1073	c.513C>T	c.(511-513)ATC>ATT	p.I171I	KCTD1_uc010xbj.1_Silent_p.I779I|KCTD1_uc010xbk.1_Silent_p.I171I|KCTD1_uc002kvy.2_Silent_p.I89I	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	171					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)															---	---	---	---
FAM59A	64762	broad.mit.edu	37	18	29972946	29972946	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:29972946G>A	uc002kxl.2	-	2	230	c.174C>T	c.(172-174)TGC>TGT	p.C58C	FAM59A_uc002kxk.1_Silent_p.C58C	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	58	CABIT.									ovary(1)|skin(1)	2																		---	---	---	---
KLHL14	57565	broad.mit.edu	37	18	30349887	30349887	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:30349887G>A	uc002kxm.1	-	2	1056	c.668C>T	c.(667-669)GCC>GTC	p.A223V		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	223	BACK.					cytosol|endoplasmic reticulum membrane				ovary(1)	1																		---	---	---	---
RPRD1A	55197	broad.mit.edu	37	18	33573116	33573116	+	Nonstop_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33573116A>G	uc002kzf.1	-	7	943	c.937T>C	c.(937-939)TGA>CGA	p.*313R	RPRD1A_uc002kze.1_Nonstop_Mutation_p.*277R|RPRD1A_uc002kzg.2_Nonstop_Mutation_p.*313R|RPRD1A_uc010dmw.2_Nonstop_Mutation_p.*277R	NM_018170	NP_060640	Q96P16	RPR1A_HUMAN	regulation of nuclear pre-mRNA domain containing	313										ovary(1)|breast(1)	2																		---	---	---	---
MOCOS	55034	broad.mit.edu	37	18	33780188	33780188	+	Missense_Mutation	SNP	C	T	T	rs150272391	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:33780188C>T	uc002kzq.3	+	4	865	c.842C>T	c.(841-843)GCG>GTG	p.A281V		NM_017947	NP_060417	Q96EN8	MOCOS_HUMAN	molybdenum cofactor sulfurase	281					Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	lyase activity|Mo-molybdopterin cofactor sulfurase activity|molybdenum ion binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)													---	---	---	---
TCEB3B	51224	broad.mit.edu	37	18	44560119	44560119	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:44560119C>T	uc002lcr.1	-	1	1870	c.1517G>A	c.(1516-1518)CGC>CAC	p.R506H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	506	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4																		---	---	---	---
KIAA0427	9811	broad.mit.edu	37	18	46284514	46284514	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:46284514A>G	uc002ldc.2	+	8	1094	c.809A>G	c.(808-810)AAT>AGT	p.N270S	KIAA0427_uc002ldd.2_Missense_Mutation_p.N270S|KIAA0427_uc002lde.3_5'Flank	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	270	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0																		---	---	---	---
DCC	1630	broad.mit.edu	37	18	50278528	50278528	+	Missense_Mutation	SNP	G	A	A	rs144331156	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:50278528G>A	uc002lfe.1	+	2	783	c.196G>A	c.(196-198)GAC>AAC	p.D66N	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	66	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)														---	---	---	---
C18orf54	162681	broad.mit.edu	37	18	51904599	51904599	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:51904599C>T	uc002lfn.3	+	8	1218	c.1102C>T	c.(1102-1104)CGG>TGG	p.R368W	C18orf54_uc002lfo.3_Missense_Mutation_p.R529W	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	368						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)														---	---	---	---
TCF4	6925	broad.mit.edu	37	18	52899754	52899754	+	Silent	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:52899754A>C	uc002lfz.2	-	17	2247	c.1635T>G	c.(1633-1635)ACT>ACG	p.T545T	TCF4_uc002lfw.3_Silent_p.T385T|TCF4_uc010xdu.1_Silent_p.T415T|TCF4_uc010xdv.1_Silent_p.T415T|TCF4_uc002lfx.2_Silent_p.T474T|TCF4_uc010xdw.1_Silent_p.T415T|TCF4_uc002lfy.2_Silent_p.T503T|TCF4_uc010xdx.1_Silent_p.T521T|TCF4_uc010dph.1_Silent_p.T545T|TCF4_uc010xdy.1_Silent_p.T521T|TCF4_uc002lga.2_Silent_p.T647T|TCF4_uc002lgb.1_Silent_p.T385T|TCF4_uc010dpi.2_Silent_p.T551T|TCF4_uc002lfv.2_Silent_p.T328T	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	545					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54349956	54349956	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54349956G>A	uc002lgk.1	+	5	603	c.392G>A	c.(391-393)TGC>TAC	p.C131Y	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.C131Y	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	131										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
WDR7	23335	broad.mit.edu	37	18	54591291	54591291	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:54591291T>C	uc002lgk.1	+	22	3876	c.3665T>C	c.(3664-3666)CTG>CCG	p.L1222P	WDR7_uc002lgl.1_Missense_Mutation_p.L1189P	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1222										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)														---	---	---	---
ZNF532	55205	broad.mit.edu	37	18	56648737	56648737	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:56648737G>A	uc002lho.2	+	10	3846	c.3299G>A	c.(3298-3300)CGT>CAT	p.R1100H	ZNF532_uc002lhp.2_Missense_Mutation_p.R1098H|ZNF532_uc010xeg.1_Missense_Mutation_p.R1098H|ZNF532_uc002lhr.2_Missense_Mutation_p.R1098H|ZNF532_uc002lhs.2_Missense_Mutation_p.R1098H|ZNF532_uc010xeh.1_Missense_Mutation_p.R188H	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1100	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2																		---	---	---	---
SERPINB8	5271	broad.mit.edu	37	18	61654104	61654104	+	Intron	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:61654104C>A	uc002ljv.2	+						SERPINB8_uc002lju.2_Intron|SERPINB8_uc010xex.1_Intron	NM_198833	NP_942130			serine (or cysteine) proteinase inhibitor, clade						regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)																---	---	---	---
CDH7	1005	broad.mit.edu	37	18	63547737	63547737	+	Silent	SNP	C	T	T	rs116347805	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:63547737C>T	uc002ljz.2	+	12	2290	c.1965C>T	c.(1963-1965)GAC>GAT	p.D655D	CDH7_uc002lkb.2_Silent_p.D655D	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	655	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)																---	---	---	---
CBLN2	147381	broad.mit.edu	37	18	70209141	70209141	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:70209141G>A	uc002lku.2	-	2	490	c.255C>T	c.(253-255)TCC>TCT	p.S85S	CBLN2_uc002lkv.2_Silent_p.S85S	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	85						integral to membrane					0		Esophageal squamous(42;0.131)																---	---	---	---
NETO1	81832	broad.mit.edu	37	18	70451000	70451000	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:70451000G>A	uc002lkw.2	-	7	1065	c.781C>T	c.(781-783)CGC>TGC	p.R261C	NETO1_uc002lkx.1_Missense_Mutation_p.R260C|NETO1_uc002lky.1_Missense_Mutation_p.R261C	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	261	CUB 2.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)														---	---	---	---
CNDP1	84735	broad.mit.edu	37	18	72223581	72223581	+	Silent	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:72223581C>A	uc002llq.2	+	2	244	c.33C>A	c.(31-33)TCC>TCA	p.S11S		NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	11					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)														---	---	---	---
ZNF516	9658	broad.mit.edu	37	18	74091962	74091962	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:74091962G>A	uc010dqx.1	-	3	2343	c.2108C>T	c.(2107-2109)ACG>ATG	p.T703M	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	703					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)														---	---	---	---
ATP9B	374868	broad.mit.edu	37	18	77137342	77137342	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77137342C>T	uc002lmx.2	+	30	3417	c.3403C>T	c.(3403-3405)CGC>TGC	p.R1135C	ATP9B_uc002lmw.1_Missense_Mutation_p.R1124C|ATP9B_uc002lna.2_Missense_Mutation_p.R150C|ATP9B_uc010drb.2_RNA	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	1135	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)														---	---	---	---
CTDP1	9150	broad.mit.edu	37	18	77489024	77489024	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77489024G>T	uc002lnh.1	+	11	2682	c.2535G>T	c.(2533-2535)CCG>CCT	p.P845P	CTDP1_uc002lni.1_Intron|CTDP1_uc010drd.1_Silent_p.P845P	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	845					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)														---	---	---	---
PARD6G	84552	broad.mit.edu	37	18	77918087	77918087	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr18:77918087G>A	uc002lny.2	-	3	864	c.698C>T	c.(697-699)ACG>ATG	p.T233M	LOC100130522_uc002lnx.2_Intron|LOC100130522_uc010xfn.1_Intron|LOC100130522_uc010xfo.1_Intron	NM_032510	NP_115899	Q9BYG4	PAR6G_HUMAN	PAR-6 gamma protein	233	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|tight junction assembly	cytosol|tight junction	protein binding				0		all_cancers(4;5.63e-22)|all_epithelial(4;5.86e-15)|all_lung(4;1.32e-05)|Ovarian(4;1.33e-05)|Lung NSC(4;2.77e-05)|Esophageal squamous(42;0.0157)|all_hematologic(56;0.13)|Melanoma(33;0.144)		Epithelial(2;1.48e-13)|all cancers(1;5.77e-13)|OV - Ovarian serous cystadenocarcinoma(15;2.74e-10)|BRCA - Breast invasive adenocarcinoma(31;0.00166)|STAD - Stomach adenocarcinoma(84;0.18)|Lung(128;0.23)														---	---	---	---
HCN2	610	broad.mit.edu	37	19	605125	605125	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:605125T>C	uc002lpe.2	+	3	1174	c.1121T>C	c.(1120-1122)ATG>ACG	p.M374T		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	374	Helical; Name=Segment S5; (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
POLRMT	5442	broad.mit.edu	37	19	621231	621231	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:621231C>G	uc002lpf.1	-	10	2523	c.2467G>C	c.(2467-2469)GCC>CCC	p.A823P		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	823	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PALM	5064	broad.mit.edu	37	19	746652	746652	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:746652G>A	uc002lpm.1	+	9	1196	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A	PALM_uc002lpn.1_Silent_p.A290A|PALM_uc010xfu.1_Silent_p.A199A	NM_002579	NP_002570	O75781	PALM_HUMAN	paralemmin isoform 1	334					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane					0		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)														---	---	---	---
WDR18	57418	broad.mit.edu	37	19	984397	984397	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:984397C>T	uc002lqm.1	+	1	70	c.44C>T	c.(43-45)GCC>GTC	p.A15V	WDR18_uc002lqn.1_RNA|WDR18_uc010drx.1_Missense_Mutation_p.A15V|WDR18_uc010dry.1_Missense_Mutation_p.A15V	NM_024100	NP_077005	Q9BV38	WDR18_HUMAN	WD repeat domain 18	15										skin(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
NDUFS7	374291	broad.mit.edu	37	19	1387831	1387831	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1387831G>A	uc002lse.3	+	2	81	c.38G>A	c.(37-39)CGG>CAG	p.R13Q	NDUFS7_uc002lsf.2_Missense_Mutation_p.R77Q|NDUFS7_uc002lsh.2_Missense_Mutation_p.R77Q|NDUFS7_uc002lsg.2_5'UTR	NM_024407	NP_077718	O75251	NDUS7_HUMAN	NADH-ubiquinone oxidoreductase Fe-S protein 7	13					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding|quinone binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)|Breast(49;0.00186)|Lung NSC(49;0.00292)|all_lung(49;0.00419)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	NADH(DB00157)													---	---	---	---
PCSK4	54760	broad.mit.edu	37	19	1487292	1487292	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:1487292T>C	uc002ltb.1	-	7	765	c.703A>G	c.(703-705)ACC>GCC	p.T235A	PCSK4_uc002lta.2_Missense_Mutation_p.T47A	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	235	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
DOT1L	84444	broad.mit.edu	37	19	2216574	2216574	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2216574G>A	uc002lvb.3	+	20	2254	c.2218G>A	c.(2218-2220)GCC>ACC	p.A740T	DOT1L_uc002lvc.1_Missense_Mutation_p.A34T|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Missense_Mutation_p.A34T	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	740						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
LINGO3	645191	broad.mit.edu	37	19	2290788	2290788	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2290788G>A	uc010dsx.1	-	2	1116	c.988C>T	c.(988-990)CTC>TTC	p.L330F	SPPL2B_uc010dsw.1_Intron|uc002lvo.1_5'UTR	NM_001101391	NP_001094861	P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	330	Extracellular (Potential).|LRR 11.					integral to membrane					0																		---	---	---	---
SPPL2B	56928	broad.mit.edu	37	19	2352963	2352963	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:2352963C>T	uc002lvs.2	+	16	1615	c.1535C>T	c.(1534-1536)CCG>CTG	p.P512L	SPPL2B_uc002lvr.2_3'UTR	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	512	Pro-rich.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
TBXA2R	6915	broad.mit.edu	37	19	3600160	3600160	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3600160G>A	uc002lyg.1	-	2	687	c.473C>T	c.(472-474)GCG>GTG	p.A158V	TBXA2R_uc002lye.1_Intron	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	158	Helical; Name=4; (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)													---	---	---	---
C19orf29	58509	broad.mit.edu	37	19	3614486	3614486	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3614486C>T	uc002lyh.2	-	7	1317	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	C19orf29_uc010xho.1_5'UTR|C19orf29_uc010dtn.2_Missense_Mutation_p.E270K|C19orf29_uc002lyi.3_Missense_Mutation_p.E422K|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	422						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
APBA3	9546	broad.mit.edu	37	19	3759909	3759909	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3759909G>A	uc002lyp.1	-	2	531	c.354C>T	c.(352-354)TGC>TGT	p.C118C	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	118					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
MATK	4145	broad.mit.edu	37	19	3779034	3779034	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:3779034G>A	uc002lyt.2	-	12	1553	c.1153C>T	c.(1153-1155)CGG>TGG	p.R385W	MATK_uc002lyv.2_Missense_Mutation_p.R386W|MATK_uc002lyu.2_Missense_Mutation_p.R344W|MATK_uc010dtq.2_Missense_Mutation_p.R385W	NM_139355	NP_647612	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase isoform	385	Protein kinase.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(2)|ovary(1)|lung(1)|large_intestine(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
ZBTB7A	51341	broad.mit.edu	37	19	4047985	4047985	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4047985G>A	uc002lzh.2	-	3	1595	c.1520C>T	c.(1519-1521)GCG>GTG	p.A507V	ZBTB7A_uc002lzi.2_Missense_Mutation_p.A507V	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	507					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
STAP2	55620	broad.mit.edu	37	19	4329976	4329976	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4329976C>T	uc002mab.2	-	5	534	c.437G>A	c.(436-438)CGT>CAT	p.R146H	STAP2_uc002mac.2_Missense_Mutation_p.R146H|STAP2_uc002mad.2_Missense_Mutation_p.R39H	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	146	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
CHAF1A	10036	broad.mit.edu	37	19	4409287	4409287	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4409287T>C	uc002mal.2	+	3	591	c.491T>C	c.(490-492)ATT>ACT	p.I164T		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	164	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)									Chromatin_Structure					---	---	---	---
SEMA6B	10501	broad.mit.edu	37	19	4552637	4552637	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:4552637G>A	uc010duc.1	-	9	824	c.786C>T	c.(784-786)CGC>CGT	p.R262R	SEMA6B_uc010dud.2_Silent_p.R262R|SEMA6B_uc010xih.1_Silent_p.R262R	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	262	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)														---	---	---	---
PTPRS	5802	broad.mit.edu	37	19	5208389	5208389	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5208389C>T	uc002mbv.2	-	36	5735	c.5501G>A	c.(5500-5502)CGG>CAG	p.R1834Q	PTPRS_uc002mbu.1_Missense_Mutation_p.R1403Q|PTPRS_uc010xin.1_Missense_Mutation_p.R1376Q|PTPRS_uc002mbw.2_Missense_Mutation_p.R1796Q|PTPRS_uc002mbx.2_Missense_Mutation_p.R1391Q|PTPRS_uc002mby.2_Missense_Mutation_p.R1387Q	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1834	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)														---	---	---	---
LONP1	9361	broad.mit.edu	37	19	5713220	5713220	+	Missense_Mutation	SNP	G	A	A	rs147052599		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:5713220G>A	uc002mcx.2	-	3	596	c.563C>T	c.(562-564)ACG>ATG	p.T188M	LONP1_uc002mcy.2_Missense_Mutation_p.T124M|LONP1_uc010duh.2_Translation_Start_Site|LONP1_uc010dui.2_Missense_Mutation_p.T188M|LONP1_uc002mcz.2_Translation_Start_Site	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	188	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0																		---	---	---	---
SLC25A41	284427	broad.mit.edu	37	19	6429808	6429808	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6429808G>T	uc010dus.2	-	4	637	c.551C>A	c.(550-552)CCG>CAG	p.P184Q	SLC25A41_uc010dut.2_Missense_Mutation_p.P46Q	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	184	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0																		---	---	---	---
TUBB4	10382	broad.mit.edu	37	19	6495747	6495747	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:6495747C>T	uc002mfg.1	-	4	870	c.763G>A	c.(763-765)GTC>ATC	p.V255I	TUBB4_uc002mff.1_Missense_Mutation_p.V183I|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	255					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)														---	---	---	---
INSR	3643	broad.mit.edu	37	19	7184342	7184342	+	Missense_Mutation	SNP	G	A	A	rs138528064	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7184342G>A	uc002mgd.1	-	3	1068	c.959C>T	c.(958-960)ACG>ATG	p.T320M	INSR_uc002mge.1_Missense_Mutation_p.T320M|INSR_uc002mgf.2_Missense_Mutation_p.T320M	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	320	Cys-rich.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)													---	---	---	---
PNPLA6	10908	broad.mit.edu	37	19	7620635	7620635	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7620635C>T	uc010xjq.1	+	26	3304	c.3109C>T	c.(3109-3111)CGG>TGG	p.R1037W	PNPLA6_uc002mgq.1_Missense_Mutation_p.R989W|PNPLA6_uc010xjp.1_Missense_Mutation_p.R962W|PNPLA6_uc002mgr.1_Missense_Mutation_p.R989W|PNPLA6_uc002mgs.2_Missense_Mutation_p.R1027W|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1028	Patatin.|Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3																		---	---	---	---
XAB2	56949	broad.mit.edu	37	19	7687526	7687526	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:7687526G>A	uc002mgx.2	-	11	1419	c.1393C>T	c.(1393-1395)CGC>TGC	p.R465C		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	465					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4													Direct_reversal_of_damage|NER					---	---	---	---
HNRNPM	4670	broad.mit.edu	37	19	8533700	8533700	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8533700C>T	uc010dwe.2	+	9	957	c.877C>T	c.(877-879)CGT>TGT	p.R293C	HNRNPM_uc010dwc.1_Missense_Mutation_p.R293C|HNRNPM_uc010xke.1_Missense_Mutation_p.R254C|HNRNPM_uc010dwd.2_Missense_Mutation_p.R254C|HNRNPM_uc002mka.2_Missense_Mutation_p.R173C	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	293					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0																		---	---	---	---
MYO1F	4542	broad.mit.edu	37	19	8609213	8609213	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8609213C>T	uc002mkg.2	-	14	1606	c.1492G>A	c.(1492-1494)GCC>ACC	p.A498T		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	498	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	8982158	8982158	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:8982158G>A	uc002mkp.2	-	70	42321	c.42117C>T	c.(42115-42117)AAC>AAT	p.N14039N	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.N856N|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	14064	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9057156	9057156	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9057156T>C	uc002mkp.2	-	3	30494	c.30290A>G	c.(30289-30291)CAT>CGT	p.H10097R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10099	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
MUC16	94025	broad.mit.edu	37	19	9067923	9067923	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9067923G>T	uc002mkp.2	-	3	19727	c.19523C>A	c.(19522-19524)ACC>AAC	p.T6508N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6510	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57																		---	---	---	---
ZNF317	57693	broad.mit.edu	37	19	9270837	9270837	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9270837C>T	uc002mku.2	+	7	791	c.516C>T	c.(514-516)TTC>TTT	p.F172F	ZNF317_uc002mkv.2_Silent_p.F31F|ZNF317_uc002mkw.2_Silent_p.F140F|ZNF317_uc002mkx.2_Silent_p.F87F|ZNF317_uc002mky.2_Silent_p.F55F	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
OLFM2	93145	broad.mit.edu	37	19	9964945	9964945	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:9964945C>T	uc002mmp.2	-	6	1310	c.1282G>A	c.(1282-1284)GCC>ACC	p.A428T	OLFM2_uc002mmo.2_Missense_Mutation_p.A350T	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	428	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2																		---	---	---	---
COL5A3	50509	broad.mit.edu	37	19	10116738	10116738	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10116738C>T	uc002mmq.1	-							NM_015719	NP_056534			collagen, type V, alpha 3 preproprotein						collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)															---	---	---	---
SLC44A2	57153	broad.mit.edu	37	19	10746197	10746197	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10746197C>T	uc002mpf.2	+						SLC44A2_uc002mpe.3_Intron|SLC44A2_uc002mpg.1_Intron|SLC44A2_uc002mph.2_5'Flank	NM_020428	NP_065161			solute carrier family 44, member 2 isoform 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)													---	---	---	---
DNM2	1785	broad.mit.edu	37	19	10908058	10908058	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:10908058C>T	uc002mps.1	+	10	1363	c.1199C>T	c.(1198-1200)ACG>ATG	p.T400M	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Intron|DNM2_uc002mpv.1_Missense_Mutation_p.T400M|DNM2_uc002mpu.1_Intron|DNM2_uc010dxl.1_Intron|DNM2_uc002mpw.2_Missense_Mutation_p.T133M	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	400					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)															---	---	---	---
CARM1	10498	broad.mit.edu	37	19	11022862	11022862	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:11022862C>T	uc002mpz.2	+	5	687	c.561C>T	c.(559-561)ATC>ATT	p.I187I	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_5'UTR	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	187					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0																		---	---	---	---
ZNF44	51710	broad.mit.edu	37	19	12386785	12386785	+	Missense_Mutation	SNP	T	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12386785T>G	uc010xmj.1	-	3	465	c.260A>C	c.(259-261)AAC>ACC	p.N87T	ZNF44_uc002mtl.2_RNA|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.N39T	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	87	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)														---	---	---	---
ZNF799	90576	broad.mit.edu	37	19	12501627	12501627	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12501627C>T	uc010dyt.2	-	4	1735	c.1585G>A	c.(1585-1587)GAG>AAG	p.E529K	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6																		---	---	---	---
RTBDN	83546	broad.mit.edu	37	19	12939701	12939701	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:12939701C>T	uc002mvi.2	-	3	366	c.236G>A	c.(235-237)TGT>TAT	p.C79Y	RTBDN_uc002mvh.1_Missense_Mutation_p.C111Y|RTBDN_uc002mvj.2_Missense_Mutation_p.C111Y	NM_001080997	NP_001074466	Q9BSG5	RTBDN_HUMAN	retbindin isoform 1	79						extracellular region					0																		---	---	---	---
NACC1	112939	broad.mit.edu	37	19	13248313	13248313	+	Silent	SNP	C	T	T	rs140114730		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13248313C>T	uc002mwm.2	+	5	1416	c.1248C>T	c.(1246-1248)TGC>TGT	p.C416C		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	416	BEN.				negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0																		---	---	---	---
NANOS3	342977	broad.mit.edu	37	19	13988417	13988417	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:13988417C>T	uc002mxj.3	+	1	468	c.355C>T	c.(355-357)CGT>TGT	p.R119C		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	100	C2HC 2.|Nanos-type.				anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)															---	---	---	---
IL27RA	9466	broad.mit.edu	37	19	14159963	14159963	+	Intron	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14159963C>A	uc002mxx.2	+							NM_004843	NP_004834			class I cytokine receptor precursor						cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0																OREG0025303	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
IL27RA	9466	broad.mit.edu	37	19	14163010	14163010	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:14163010G>A	uc002mxx.2	+	14	2242	c.1819G>A	c.(1819-1821)GCC>ACC	p.A607T		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	607	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0																		---	---	---	---
NWD1	284434	broad.mit.edu	37	19	16910892	16910892	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16910892G>A	uc002neu.3	+	17	4077	c.3655G>A	c.(3655-3657)GCA>ACA	p.A1219T	NWD1_uc002net.3_Missense_Mutation_p.A1084T|NWD1_uc002nev.3_Missense_Mutation_p.A1013T			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1219	WD 10.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7																		---	---	---	---
SIN3B	23309	broad.mit.edu	37	19	16989157	16989157	+	Missense_Mutation	SNP	G	A	A	rs138372644	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:16989157G>A	uc002ney.1	+	19	3228	c.3214G>A	c.(3214-3216)GAG>AAG	p.E1072K	SIN3B_uc002nez.1_Missense_Mutation_p.E1040K|SIN3B_uc010xpi.1_Missense_Mutation_p.E630K|SIN3B_uc010eaj.1_Missense_Mutation_p.E8K	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	1072					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2																		---	---	---	---
SLC27A1	376497	broad.mit.edu	37	19	17608192	17608192	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17608192G>A	uc002ngu.1	+	7	1175	c.1125G>A	c.(1123-1125)ACG>ACA	p.T375T	SLC27A1_uc002ngt.1_Silent_p.T107T|SLC27A1_uc010xpp.1_Silent_p.T196T|SLC27A1_uc002ngv.1_5'UTR	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	375	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0																		---	---	---	---
GLT25D1	79709	broad.mit.edu	37	19	17679462	17679462	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17679462C>A	uc002nhc.1	+	5	781	c.769C>A	c.(769-771)CCT>ACT	p.P257T	GLT25D1_uc010eax.1_Missense_Mutation_p.P25T	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	257					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17766790	17766790	+	Silent	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17766790G>T	uc002nhd.2	-	11	1449	c.1449C>A	c.(1447-1449)GCC>GCA	p.A483A		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	395					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
UNC13A	23025	broad.mit.edu	37	19	17768952	17768952	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:17768952C>T	uc002nhd.2	-	10	950	c.950G>A	c.(949-951)CGC>CAC	p.R317H		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	229					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3																		---	---	---	---
GDF15	9518	broad.mit.edu	37	19	18499542	18499542	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:18499542G>A	uc002niv.2	+	2	756	c.724G>A	c.(724-726)GGC>AGC	p.G242S		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	242					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1																OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
SFRS14	10147	broad.mit.edu	37	19	19115218	19115218	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19115218G>C	uc002nkx.2	-	7	2834	c.2688C>G	c.(2686-2688)GAC>GAG	p.D896E	SFRS14_uc002nkz.1_Missense_Mutation_p.D910E|SFRS14_uc002nla.1_Missense_Mutation_p.D896E|SFRS14_uc002nlb.2_Missense_Mutation_p.D896E|SFRS14_uc010xqk.1_Missense_Mutation_p.D665E	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	896	Asp/Glu-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)															---	---	---	---
SLC25A42	284439	broad.mit.edu	37	19	19206971	19206971	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19206971A>G	uc002nlf.1	+	2	189	c.38A>G	c.(37-39)CAT>CGT	p.H13R	SLC25A42_uc010xqn.1_Missense_Mutation_p.H65R	NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	13					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)															---	---	---	---
TMEM161A	54929	broad.mit.edu	37	19	19231610	19231610	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19231610G>T	uc002nlg.2	-	11	1180	c.1150C>A	c.(1150-1152)CTC>ATC	p.L384I	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.L359I|TMEM161A_uc002nli.2_Missense_Mutation_p.L281I|TMEM161A_uc002nlj.2_Missense_Mutation_p.L259I	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	384	Helical; (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)															---	---	---	---
MEF2B	100271849	broad.mit.edu	37	19	19260102	19260102	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19260102C>T	uc002nlm.2	-	3	305	c.191G>A	c.(190-192)CGT>CAT	p.R64H	MEF2B_uc002nln.2_Missense_Mutation_p.R111H|MEF2B_uc002nll.2_Missense_Mutation_p.R64H|LOC729991-MEF2B_uc010xqo.1_Missense_Mutation_p.R64H|LOC729991-MEF2B_uc010xqp.1_Missense_Mutation_p.R64H|LOC729991-MEF2B_uc002nlo.2_Missense_Mutation_p.R64H|LOC729991-MEF2B_uc002nlp.2_Missense_Mutation_p.R64H|MEF2B_uc002nlk.2_Missense_Mutation_p.R64H	NM_001145785	NP_001139257			myocyte enhancer factor 2B isoform a											skin(1)	1			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)															---	---	---	---
NR2C2AP	126382	broad.mit.edu	37	19	19313841	19313841	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19313841G>A	uc002nlx.2	-	1	398	c.29C>T	c.(28-30)ACA>ATA	p.T10I	NR2C2AP_uc010xqq.1_5'Flank|NR2C2AP_uc002nly.2_Missense_Mutation_p.T10I	NM_176880	NP_795361	Q86WQ0	NR2CA_HUMAN	TR4 orphan receptor associated protein TRA16	10					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				ovary(1)	1			Epithelial(12;0.00235)															---	---	---	---
NCAN	1463	broad.mit.edu	37	19	19329894	19329894	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19329894C>T	uc002nlz.2	+	3	343	c.244C>T	c.(244-246)CGG>TGG	p.R82W		NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	82	Ig-like V-type.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)															---	---	---	---
CILP2	148113	broad.mit.edu	37	19	19655681	19655681	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:19655681G>A	uc002nmv.3	+	8	2412	c.2327G>A	c.(2326-2328)CGT>CAT	p.R776H	CILP2_uc002nmw.3_Missense_Mutation_p.R782H	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	776						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1																		---	---	---	---
ZNF85	7639	broad.mit.edu	37	19	21132705	21132705	+	Missense_Mutation	SNP	C	T	T	rs140408195		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21132705C>T	uc002npg.3	+	4	1512	c.1385C>T	c.(1384-1386)GCT>GTT	p.A462V	ZNF85_uc010ecn.2_Missense_Mutation_p.A397V|ZNF85_uc010eco.2_Missense_Mutation_p.A410V|ZNF85_uc002npi.2_Missense_Mutation_p.A403V	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	462	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
ZNF43	7594	broad.mit.edu	37	19	21991748	21991748	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:21991748T>C	uc002nqj.2	-	4	1221	c.1091A>G	c.(1090-1092)CAT>CGT	p.H364R	ZNF43_uc010ecv.2_Missense_Mutation_p.H358R|ZNF43_uc002nql.2_Missense_Mutation_p.H358R|ZNF43_uc002nqm.2_Missense_Mutation_p.H358R|ZNF43_uc002nqk.2_Missense_Mutation_p.H294R	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	364	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)														---	---	---	---
TSHZ3	57616	broad.mit.edu	37	19	31767688	31767688	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:31767688C>T	uc002nsy.3	-	2	3076	c.3011G>A	c.(3010-3012)CGG>CAG	p.R1004Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1004					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)																	---	---	---	---
KIAA0355	9710	broad.mit.edu	37	19	34833300	34833300	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34833300C>T	uc002nvd.3	+	10	3320	c.2461C>T	c.(2461-2463)CGT>TGT	p.R821C		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	821										ovary(1)	1	Esophageal squamous(110;0.162)																	---	---	---	---
UBA2	10054	broad.mit.edu	37	19	34942896	34942896	+	Silent	SNP	G	A	A	rs146405147	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:34942896G>A	uc002nvk.2	+	10	952	c.882G>A	c.(880-882)ACG>ACA	p.T294T	UBA2_uc010xrx.1_Silent_p.T167T|UBA2_uc002nvl.2_Silent_p.T198T	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	294					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)															---	---	---	---
FFAR2	2867	broad.mit.edu	37	19	35940790	35940790	+	Silent	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:35940790G>C	uc002nzg.2	+	2	254	c.174G>C	c.(172-174)CTG>CTC	p.L58L	FFAR2_uc010eea.2_Silent_p.L58L	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	58	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)															---	---	---	---
ARHGAP33	115703	broad.mit.edu	37	19	36271872	36271872	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36271872C>T	uc002obr.1	+	11	965	c.880C>T	c.(880-882)CGC>TGC	p.R294C	ARHGAP33_uc002obs.1_Missense_Mutation_p.R294C|ARHGAP33_uc002obt.1_Missense_Mutation_p.R158C|ARHGAP33_uc010eel.2_5'Flank|ARHGAP33_uc002obv.1_5'Flank	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	294					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4																		---	---	---	---
NPHS1	4868	broad.mit.edu	37	19	36340038	36340038	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:36340038C>T	uc002oby.2	-	8	852	c.852G>A	c.(850-852)CCG>CCA	p.P284P		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	284	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)															---	---	---	---
ZFP30	22835	broad.mit.edu	37	19	38126847	38126847	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38126847C>T	uc002ogv.1	-	6	1111	c.595G>A	c.(595-597)GCC>ACC	p.A199T	ZFP30_uc002ogw.1_Missense_Mutation_p.A199T|ZFP30_uc002ogx.1_Missense_Mutation_p.A199T|ZFP30_uc010xtt.1_Missense_Mutation_p.A198T	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	199	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)															---	---	---	---
SIPA1L3	23094	broad.mit.edu	37	19	38610116	38610116	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38610116G>A	uc002ohk.2	+	9	2971	c.2462G>A	c.(2461-2463)CGC>CAC	p.R821H		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	821	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)															---	---	---	---
GGN	199720	broad.mit.edu	37	19	38877383	38877383	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:38877383C>T	uc002oij.1	-	3	654	c.519G>A	c.(517-519)CCG>CCA	p.P173P	GGN_uc002oik.1_Intron|GGN_uc010efy.1_Silent_p.P90P	NM_152657	NP_689870	Q86UU5	GGN_HUMAN	gametogenetin	173	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis						0	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
MAP4K1	11184	broad.mit.edu	37	19	39104547	39104547	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39104547C>T	uc002oix.1	-	8	614	c.506G>A	c.(505-507)CGC>CAC	p.R169H	MAP4K1_uc002oiy.1_Missense_Mutation_p.R169H|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	169	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)															---	---	---	---
NFKBIB	4793	broad.mit.edu	37	19	39398124	39398124	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39398124C>T	uc002ojw.2	+	5	852	c.794C>T	c.(793-795)GCG>GTG	p.A265V	NFKBIB_uc002ojx.2_Missense_Mutation_p.A233V|NFKBIB_uc002ojy.2_Missense_Mutation_p.A265V	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	265	ANK 5.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)															---	---	---	---
PAK4	10298	broad.mit.edu	37	19	39667343	39667343	+	Silent	SNP	C	A	A	rs138564503		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:39667343C>A	uc002okj.1	+	9	1934	c.1473C>A	c.(1471-1473)CCC>CCA	p.P491P	PAK4_uc002okl.1_Silent_p.P491P|PAK4_uc002okn.1_Silent_p.P491P|PAK4_uc002okm.1_Silent_p.P338P|PAK4_uc002oko.1_Silent_p.P338P|PAK4_uc002okp.1_Silent_p.P401P	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	491	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)															---	---	---	---
FBL	2091	broad.mit.edu	37	19	40328360	40328360	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40328360T>C	uc002omn.2	-	6	787	c.673A>G	c.(673-675)ATG>GTG	p.M225V	FBL_uc002omm.1_Missense_Mutation_p.M139V|FBL_uc002omo.2_Missense_Mutation_p.M224V	NM_001436	NP_001427	P22087	FBRL_HUMAN	fibrillarin	225					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			ovary(1)	1	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)														---	---	---	---
PLD3	23646	broad.mit.edu	37	19	40882619	40882619	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40882619C>T	uc002onm.3	+	11	1521	c.1123C>T	c.(1123-1125)CGG>TGG	p.R375W	PLD3_uc002onj.3_Missense_Mutation_p.R375W|PLD3_uc002onk.3_Missense_Mutation_p.R375W|PLD3_uc002onl.3_Missense_Mutation_p.R375W|PLD3_uc002onn.2_Missense_Mutation_p.R375W	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	375	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)															---	---	---	---
SERTAD1	29950	broad.mit.edu	37	19	40929007	40929007	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40929007C>T	uc002ont.3	-	2	606	c.447G>A	c.(445-447)GCG>GCA	p.A149A		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	149					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SERTAD3	29946	broad.mit.edu	37	19	40947898	40947898	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:40947898C>A	uc002onu.3	-	2	368	c.90G>T	c.(88-90)CAG>CAT	p.Q30H	SERTAD3_uc002onv.3_Missense_Mutation_p.Q30H	NM_013368	NP_037500	Q9UJW9	SRTD3_HUMAN	RPA-binding trans-activator	30	SERTA.				negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
SPTBN4	57731	broad.mit.edu	37	19	41008724	41008724	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41008724G>A	uc002ony.2	+	11	1332	c.1246G>A	c.(1246-1248)GCC>ACC	p.A416T	SPTBN4_uc002onx.2_Missense_Mutation_p.A416T|SPTBN4_uc002onz.2_Missense_Mutation_p.A416T	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	416	Spectrin 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)															---	---	---	---
CYP2B6	1555	broad.mit.edu	37	19	41510273	41510273	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41510273G>A	uc002opr.1	+	3	413	c.406G>A	c.(406-408)GGG>AGG	p.G136R	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.G96R	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	136					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)													---	---	---	---
CYP2B6	1555	broad.mit.edu	37	19	41522636	41522636	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:41522636C>T	uc002opr.1	+	9	1387	c.1380C>T	c.(1378-1380)GCC>GCT	p.A460A	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.A260A	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	460					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)													---	---	---	---
CEACAM6	4680	broad.mit.edu	37	19	42260867	42260867	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42260867C>T	uc002orm.2	+	2	573	c.424C>T	c.(424-426)CCG>TCG	p.P142S		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	142	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)														---	---	---	---
CEACAM3	1084	broad.mit.edu	37	19	42301880	42301880	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42301880C>T	uc002orn.1	+	2	500	c.424C>T	c.(424-426)CAA>TAA	p.Q142*	CEACAM3_uc010eia.1_Nonsense_Mutation_p.Q142*|CEACAM3_uc002oro.1_RNA	NM_001815	NP_001806	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion	142	Ig-like V-type.|Extracellular (Potential).					integral to membrane				skin(1)	1																		---	---	---	---
PRR19	284338	broad.mit.edu	37	19	42813800	42813800	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:42813800C>T	uc002oti.2	+	2	442	c.64C>T	c.(64-66)CGT>TGT	p.R22C	PRR19_uc002oth.1_Missense_Mutation_p.R22C|PRR19_uc002otj.2_Missense_Mutation_p.R22C	NM_199285	NP_954979	A6NJB7	PRR19_HUMAN	proline rich 19	22											0		Prostate(69;0.00682)																---	---	---	---
PSG7	5676	broad.mit.edu	37	19	43430100	43430100	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43430100C>T	uc002ovl.3	-	6	1170	c.1068G>A	c.(1066-1068)GCG>GCA	p.A356A	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Silent_p.A269A|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Silent_p.A82A|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.A269A|PSG7_uc010xwl.1_Silent_p.A234A	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	356	Ig-like C2-type 3.				female pregnancy	extracellular region					0		Prostate(69;0.00682)																---	---	---	---
PSG7	5676	broad.mit.edu	37	19	43441204	43441204	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:43441204A>G	uc002ovl.3	-	1	127	c.25T>C	c.(25-27)TGC>CGC	p.C9R	PSG3_uc002ouf.2_5'Flank|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.C9R	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	9					female pregnancy	extracellular region					0		Prostate(69;0.00682)																---	---	---	---
VASP	7408	broad.mit.edu	37	19	46027364	46027364	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46027364G>A	uc002pcg.2	+	10	1262	c.920G>A	c.(919-921)CGG>CAG	p.R307Q	VASP_uc010eki.2_Missense_Mutation_p.R141Q|VASP_uc002pci.2_Missense_Mutation_p.R293Q	NM_003370	NP_003361	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	307	EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)												OREG0025556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
VASP	7408	broad.mit.edu	37	19	46027366	46027366	+	Silent	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46027366A>C	uc002pcg.2	+	10	1264	c.922A>C	c.(922-924)AGA>CGA	p.R308R	VASP_uc010eki.2_Silent_p.R142R|VASP_uc002pci.2_Silent_p.R294R	NM_003370	NP_003361	P50552	VASP_HUMAN	vasodilator-stimulated phosphoprotein	308	EVH2.				axon guidance|cell junction assembly|T cell receptor signaling pathway	actin cytoskeleton|cytosol|filopodium membrane|focal adhesion|lamellipodium membrane	actin binding|profilin binding|SH3 domain binding				0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0145)|GBM - Glioblastoma multiforme(486;0.154)												OREG0025556	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
FBXO46	23403	broad.mit.edu	37	19	46216376	46216376	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46216376G>A	uc002pcy.2	-	2	503	c.378C>T	c.(376-378)AGC>AGT	p.S126S	FBXO46_uc002pcz.2_Silent_p.S126S	NM_001080469	NP_001073938	Q6PJ61	FBX46_HUMAN	F-box protein 46	126							protein binding			ovary(1)|lung(1)|breast(1)	3		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)														---	---	---	---
DMWD	1762	broad.mit.edu	37	19	46289337	46289337	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:46289337C>T	uc002pdj.1	-	3	1463	c.1417G>A	c.(1417-1419)GCC>ACC	p.A473T	DMWD_uc002pdk.1_Missense_Mutation_p.A473T|DMWD_uc010eko.1_Missense_Mutation_p.A158T	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	473					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)														---	---	---	---
SLC1A5	6510	broad.mit.edu	37	19	47282088	47282088	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:47282088C>T	uc002pfs.2	-	5	1522	c.902G>A	c.(901-903)CGC>CAC	p.R301H	SLC1A5_uc010xyh.1_Missense_Mutation_p.R99H|SLC1A5_uc002pfq.2_Missense_Mutation_p.R125H|SLC1A5_uc002pfr.2_Missense_Mutation_p.R73H	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	301					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)													---	---	---	---
SLC17A7	57030	broad.mit.edu	37	19	49934362	49934362	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:49934362G>A	uc002pnp.2	-	11	1471	c.1299C>T	c.(1297-1299)TAC>TAT	p.Y433Y	SLC17A7_uc002pno.2_Silent_p.Y95Y	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	433	Cytoplasmic (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50098862	50098862	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50098862G>A	uc002poo.3	+	4	1270	c.1270G>A	c.(1270-1272)GCA>ACA	p.A424T		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50098867	50098867	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50098867C>T	uc002poo.3	+	4	1275	c.1275C>T	c.(1273-1275)GCC>GCT	p.A425A		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
PRR12	57479	broad.mit.edu	37	19	50099458	50099458	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50099458G>A	uc002poo.3	+	4	1866	c.1866G>A	c.(1864-1866)TCG>TCA	p.S622S		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)														---	---	---	---
MYH14	79784	broad.mit.edu	37	19	50796825	50796825	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50796825G>T	uc002prr.1	+	37	5274	c.5227G>T	c.(5227-5229)GCC>TCC	p.A1743S	MYH14_uc010enu.1_Missense_Mutation_p.A1784S|MYH14_uc002prq.1_Missense_Mutation_p.A1751S|MYH14_uc010ycb.1_Missense_Mutation_p.A94S|MYH14_uc002prs.1_Missense_Mutation_p.A94S	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1743	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)														---	---	---	---
MYBPC2	4606	broad.mit.edu	37	19	50961966	50961966	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:50961966G>A	uc002psf.2	+	21	2512	c.2461G>A	c.(2461-2463)GAG>AAG	p.E821K		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	821	Fibronectin type-III 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)														---	---	---	---
KLK15	55554	broad.mit.edu	37	19	51329054	51329054	+	Nonstop_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51329054A>G	uc002ptl.2	-	5	800	c.769T>C	c.(769-771)TGA>CGA	p.*257R	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Nonstop_Mutation_p.*172R|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Nonstop_Mutation_p.*256R|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	257					proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)														---	---	---	---
KLK15	55554	broad.mit.edu	37	19	51330304	51330304	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51330304C>T	uc002ptl.2	-	3	342	c.311G>A	c.(310-312)CGC>CAC	p.R104H	KLK15_uc002ptm.2_Missense_Mutation_p.R104H|KLK15_uc002ptn.2_Missense_Mutation_p.R104H|KLK15_uc002pto.2_Missense_Mutation_p.R103H|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_Missense_Mutation_p.R103H|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	104	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)														---	---	---	---
ETFB	2109	broad.mit.edu	37	19	51848643	51848643	+	Intron	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:51848643T>C	uc002pwh.2	-						ETFB_uc002pwg.2_Intron	NM_001985	NP_001976			electron-transfer-flavoprotein, beta polypeptide						respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)														---	---	---	---
MIR515-1	574462	broad.mit.edu	37	19	54182264	54182264	+	RNA	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54182264C>T	hsa-mir-515-1|MI0003144	+			c.8C>T			uc010ydz.1_RNA|MIR519E_hsa-mir-519e|MI0003145_5'Flank																	0																		---	---	---	---
LENG1	79165	broad.mit.edu	37	19	54662136	54662136	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54662136C>T	uc002qdm.2	-	2	209	c.196G>A	c.(196-198)GCA>ACA	p.A66T		NM_024316	NP_077292	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	66										ovary(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)																	---	---	---	---
LILRA6	79168	broad.mit.edu	37	19	54742915	54742915	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:54742915C>T	uc002qeu.1	-	8	1484	c.1360G>A	c.(1360-1362)GCA>ACA	p.A454T	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.A298T	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	454	Helical; (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)														---	---	---	---
NLRP7	199713	broad.mit.edu	37	19	55450647	55450647	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55450647C>T	uc002qih.3	-	4	1616	c.1540G>A	c.(1540-1542)GAC>AAC	p.D514N	NLRP7_uc002qig.3_Missense_Mutation_p.D514N|NLRP7_uc002qii.3_Missense_Mutation_p.D514N|NLRP7_uc010esk.2_Missense_Mutation_p.D514N|NLRP7_uc010esl.2_Missense_Mutation_p.D542N	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	514							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
NLRP2	55655	broad.mit.edu	37	19	55494233	55494233	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55494233G>A	uc002qij.2	+	6	1253	c.1167G>A	c.(1165-1167)GCG>GCA	p.A389A	NLRP2_uc010yfp.1_Silent_p.A366A|NLRP2_uc010esn.2_Silent_p.A365A|NLRP2_uc010eso.2_Silent_p.A386A|NLRP2_uc010esp.2_Silent_p.A367A	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	389	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)														---	---	---	---
ZNF628	89887	broad.mit.edu	37	19	55994334	55994334	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55994334C>T	uc002qld.2	+	3	2327	c.1762C>T	c.(1762-1764)CGG>TGG	p.R588W	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	588						nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)														---	---	---	---
ZNF628	89887	broad.mit.edu	37	19	55995297	55995297	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:55995297G>A	uc002qld.2	+	3	3290	c.2725G>A	c.(2725-2727)GAG>AAG	p.E909K	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	909						nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)														---	---	---	---
NLRP11	204801	broad.mit.edu	37	19	56307593	56307593	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:56307593G>A	uc010ygf.1	-	8	2906	c.2195C>T	c.(2194-2196)GCC>GTC	p.A732V	NLRP11_uc002qlz.2_Missense_Mutation_p.A579V|NLRP11_uc002qmb.2_Missense_Mutation_p.A633V|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	732							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)														---	---	---	---
ZNF71	58491	broad.mit.edu	37	19	57133494	57133494	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:57133494G>A	uc002qnm.3	+	3	1077	c.839G>A	c.(838-840)AGC>AAC	p.S280N		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	280	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)														---	---	---	---
ZSCAN22	342945	broad.mit.edu	37	19	58850459	58850459	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58850459C>T	uc002qsc.2	+	3	1390	c.1243C>T	c.(1243-1245)CGA>TGA	p.R415*	ZSCAN22_uc010yhz.1_3'UTR	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	415	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)														---	---	---	---
A1BG	1	broad.mit.edu	37	19	58864812	58864812	+	5'UTR	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58864812C>T	uc002qsd.3	-	1					NCRNA00181_uc002qse.2_RNA|A1BG_uc002qsf.1_Intron|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602			alpha 1B-glycoprotein precursor							extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)														---	---	---	---
ZNF324B	388569	broad.mit.edu	37	19	58967425	58967425	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58967425G>A	uc002qsv.1	+	4	1221	c.1114G>A	c.(1114-1116)GCA>ACA	p.A372T	ZNF324B_uc002qsu.1_Missense_Mutation_p.A362T|ZNF324B_uc010euq.1_Missense_Mutation_p.A372T	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	372	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZNF324	25799	broad.mit.edu	37	19	58982534	58982534	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58982534T>C	uc002qsw.1	+	4	769	c.675T>C	c.(673-675)GGT>GGC	p.G225G	ZNF324_uc002qsx.1_Silent_p.G2G	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZNF324	25799	broad.mit.edu	37	19	58982539	58982539	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58982539T>C	uc002qsw.1	+	4	774	c.680T>C	c.(679-681)GTT>GCT	p.V227A	ZNF324_uc002qsx.1_Missense_Mutation_p.V4A	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZNF446	55663	broad.mit.edu	37	19	58988598	58988598	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr19:58988598C>T	uc002qsz.2	+	2	130	c.13C>T	c.(13-15)CTG>TTG	p.L5L	ZNF446_uc002qta.2_Silent_p.L5L|ZNF446_uc010eur.2_Silent_p.L5L	NM_017908	NP_060378	Q9NWS9	ZN446_HUMAN	zinc finger protein 446	5					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)														---	---	---	---
ZCCHC3	85364	broad.mit.edu	37	20	279025	279025	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:279025C>T	uc002wdf.2	+	2	819	c.795C>T	c.(793-795)GAC>GAT	p.D265D	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	266							nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)															---	---	---	---
TCF15	6939	broad.mit.edu	37	20	590455	590455	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:590455C>T	uc002wdz.2	-	1	456	c.427G>A	c.(427-429)GCC>ACC	p.A143T		NM_004609	NP_004600	Q12870	TCF15_HUMAN	basic helix-loop-helix transcription factor 15	143					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(17;0.231)																---	---	---	---
SNPH	9751	broad.mit.edu	37	20	1281343	1281343	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1281343G>A	uc002wes.2	+	5	532	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	SNPH_uc002wet.2_Missense_Mutation_p.R143Q	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	99	Potential.				synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2																		---	---	---	---
SIRPB1	10326	broad.mit.edu	37	20	1559072	1559072	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:1559072G>A	uc010gai.2	-	2	444	c.345C>T	c.(343-345)GCC>GCT	p.A115A	SIRPB1_uc002wfk.3_Silent_p.A115A	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	115	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1																		---	---	---	---
IDH3B	3420	broad.mit.edu	37	20	2640407	2640407	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2640407G>A	uc002wgp.2	-	10	957	c.948C>T	c.(946-948)GGC>GGT	p.G316G	IDH3B_uc002wgq.2_Silent_p.G316G|IDH3B_uc002wgr.2_Silent_p.G164G	NM_006899	NP_008830	O43837	IDH3B_HUMAN	isocitrate dehydrogenase 3, beta subunit isoform	316					isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	electron carrier activity|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0					NADH(DB00157)													---	---	---	---
VPS16	64601	broad.mit.edu	37	20	2841159	2841159	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:2841159C>T	uc002whe.2	+	5	482	c.434C>T	c.(433-435)GCC>GTC	p.A145V	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.A145V|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	145					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4																		---	---	---	---
ProSAPiP1	9762	broad.mit.edu	37	20	3146682	3146682	+	Missense_Mutation	SNP	C	T	T	rs113680437		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3146682C>T	uc002wia.1	-	2	2182	c.784G>A	c.(784-786)GGC>AGC	p.G262S	ProSAPiP1_uc002wib.1_Missense_Mutation_p.G262S	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	262						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1																		---	---	---	---
SIGLEC1	6614	broad.mit.edu	37	20	3669866	3669866	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:3669866C>T	uc002wja.2	-	20	5006	c.5006G>A	c.(5005-5007)CGT>CAT	p.R1669H	SIGLEC1_uc002wjb.1_3'UTR|SIGLEC1_uc002wiz.3_Intron	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1669	Cytoplasmic (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding	p.1670_1673del(1)		pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10																		---	---	---	---
ADRA1D	146	broad.mit.edu	37	20	4229097	4229097	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4229097C>T	uc002wkr.2	-	1	563	c.508G>A	c.(508-510)GAC>AAC	p.D170N		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	170	Helical; Name=3; (By similarity).				cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)													---	---	---	---
PRND	23627	broad.mit.edu	37	20	4705664	4705664	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:4705664G>A	uc002wkz.2	+	2	538	c.467G>A	c.(466-468)CGG>CAG	p.R156Q		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	156					protein homooligomerization	anchored to membrane|plasma membrane					0																		---	---	---	---
MCM8	84515	broad.mit.edu	37	20	5952655	5952655	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:5952655C>T	uc002wmi.2	+	11	1603	c.1226C>T	c.(1225-1227)TCG>TTG	p.S409L	MCM8_uc002wmj.2_Missense_Mutation_p.S393L|MCM8_uc002wmk.2_Intron|MCM8_uc002wml.2_Missense_Mutation_p.S409L|MCM8_uc010gbp.2_Missense_Mutation_p.S409L|MCM8_uc002wmm.2_5'UTR	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	409	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1																		---	---	---	---
LRRN4	164312	broad.mit.edu	37	20	6021949	6021949	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:6021949G>A	uc002wmo.2	-	5	2166	c.1942C>T	c.(1942-1944)CGC>TGC	p.R648C		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	648	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(3)	3																		---	---	---	---
C20orf94	128710	broad.mit.edu	37	20	10582435	10582435	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:10582435C>T	uc010zre.1	+	6	553	c.373C>T	c.(373-375)CGT>TGT	p.R125C		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	125							protein binding				0																		---	---	---	---
RRBP1	6238	broad.mit.edu	37	20	17596180	17596180	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17596180C>T	uc002wpv.1	-						RRBP1_uc010zrp.1_Intron|RRBP1_uc002wpt.1_Intron|RRBP1_uc002wpu.2_Intron|RRBP1_uc002wpw.1_Intron|RRBP1_uc010gcl.1_Intron	NM_001042576	NP_001036041			ribosome binding protein 1						protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1																		---	---	---	---
RRBP1	6238	broad.mit.edu	37	20	17601385	17601385	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17601385C>T	uc002wpv.1	-	18	2537	c.2183G>A	c.(2182-2184)GGC>GAC	p.G728D	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_Missense_Mutation_p.G98D|RRBP1_uc002wpu.2_Missense_Mutation_p.G502D|RRBP1_uc002wpw.1_Missense_Mutation_p.G728D|RRBP1_uc010gcl.1_Missense_Mutation_p.G502D|RRBP1_uc010gcm.1_Missense_Mutation_p.G181D	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1161	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1																		---	---	---	---
RRBP1	6238	broad.mit.edu	37	20	17601390	17601390	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17601390C>A	uc002wpv.1	-	18	2532	c.2178G>T	c.(2176-2178)AAG>AAT	p.K726N	RRBP1_uc010zrp.1_5'Flank|RRBP1_uc002wpt.1_Missense_Mutation_p.K96N|RRBP1_uc002wpu.2_Missense_Mutation_p.K500N|RRBP1_uc002wpw.1_Missense_Mutation_p.K726N|RRBP1_uc010gcl.1_Missense_Mutation_p.K500N|RRBP1_uc010gcm.1_Missense_Mutation_p.K179N	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1159	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1																		---	---	---	---
RRBP1	6238	broad.mit.edu	37	20	17617252	17617252	+	Translation_Start_Site	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:17617252G>A	uc010gcm.1	-	1	123	c.-235C>T	c.(-237--233)CACGT>CATGT		RRBP1_uc002wpu.2_Silent_p.H110H|RRBP1_uc002wpv.1_Silent_p.H336H|RRBP1_uc002wpw.1_Silent_p.H336H|RRBP1_uc010gcl.1_Silent_p.H110H					Homo sapiens mRNA for KIAA1398 protein, partial cds.						protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1																		---	---	---	---
RALGAPA2	57186	broad.mit.edu	37	20	20527373	20527373	+	Missense_Mutation	SNP	C	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:20527373C>A	uc002wrz.2	-	24	3403	c.3260G>T	c.(3259-3261)AGG>ATG	p.R1087M	RALGAPA2_uc010gcx.2_Missense_Mutation_p.R791M|RALGAPA2_uc010zsg.1_Missense_Mutation_p.R535M	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1087					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1																		---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21312221	21312221	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21312221C>T	uc002wsf.1	+	7	694	c.599C>T	c.(598-600)GCT>GTT	p.A200V	XRN2_uc002wsg.1_Missense_Mutation_p.A124V|XRN2_uc010zsk.1_Missense_Mutation_p.A146V	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	200					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
XRN2	22803	broad.mit.edu	37	20	21369921	21369921	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:21369921G>A	uc002wsf.1	+	30	2893	c.2798G>A	c.(2797-2799)AGA>AAA	p.R933K	XRN2_uc002wsg.1_Missense_Mutation_p.R857K|XRN2_uc010zsk.1_Missense_Mutation_p.R879K|XRN2_uc002wsh.1_Missense_Mutation_p.R71K	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	933					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1																		---	---	---	---
TMEM90B	79953	broad.mit.edu	37	20	24523741	24523741	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:24523741G>A	uc002wtw.1	+	2	641	c.8G>A	c.(7-9)GGC>GAC	p.G3D		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	3	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0																		---	---	---	---
ASXL1	171023	broad.mit.edu	37	20	31021635	31021635	+	Missense_Mutation	SNP	G	A	A	rs149449801		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31021635G>A	uc002wxs.2	+	11	2060	c.1634G>A	c.(1633-1635)CGT>CAT	p.R545H	ASXL1_uc010geb.2_Missense_Mutation_p.R436H	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	545					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248								F|N|Mis		MDS|CMML								---	---	---	---
C20orf112	140688	broad.mit.edu	37	20	31044122	31044122	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:31044122G>A	uc002wxu.3	-	3	343	c.186C>T	c.(184-186)GGC>GGT	p.G62G	C20orf112_uc010gec.2_5'UTR	NM_080616	NP_542183	Q96MY1	CT112_HUMAN	hypothetical protein LOC140688	62											0																		---	---	---	---
CBFA2T2	9139	broad.mit.edu	37	20	32232182	32232182	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32232182C>T	uc002wzg.1	+	12	2082	c.1545C>T	c.(1543-1545)AGC>AGT	p.S515S	CBFA2T2_uc010zug.1_Silent_p.S289S|CBFA2T2_uc002wze.1_Silent_p.S506S|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.S486S|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA|CBFA2T2_uc002wzk.1_Silent_p.S63S	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	515						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2																		---	---	---	---
PXMP4	11264	broad.mit.edu	37	20	32298427	32298427	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:32298427G>A	uc002wzv.2	-	3	432	c.309C>T	c.(307-309)CAC>CAT	p.H103H	PXMP4_uc002wzw.2_Intron|PXMP4_uc010zuh.1_Missense_Mutation_p.T110M	NM_007238	NP_009169	Q9Y6I8	PXMP4_HUMAN	peroxisomal membrane protein 4 isoform a	103	Helical; (Potential).					integral to membrane|membrane fraction|mitochondrial inner membrane|peroxisomal membrane	protein transporter activity				0																		---	---	---	---
MYH7B	57644	broad.mit.edu	37	20	33572650	33572650	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:33572650G>A	uc002xbi.1	+							NM_020884	NP_065935			myosin, heavy polypeptide 7B, cardiac muscle,							membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)															---	---	---	---
GDF5	8200	broad.mit.edu	37	20	34022216	34022216	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34022216C>T	uc002xck.1	-	2	1316	c.997G>A	c.(997-999)GCC>ACC	p.A333T	GDF5_uc010gfc.1_Missense_Mutation_p.A333T|uc002xcj.2_Silent_p.G209G|GDF5_uc010zvc.1_Missense_Mutation_p.A333T	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	333					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)															---	---	---	---
PHF20	51230	broad.mit.edu	37	20	34526962	34526962	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:34526962C>T	uc002xek.1	+	16	2755	c.2644C>T	c.(2644-2646)CGC>TGC	p.R882C		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)																	---	---	---	---
DLGAP4	22839	broad.mit.edu	37	20	35061124	35061124	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35061124G>A	uc002xff.2	+						DLGAP4_uc010zvp.1_Intron	NM_014902	NP_055717			disks large-associated protein 4 isoform a						cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)																---	---	---	---
NDRG3	57446	broad.mit.edu	37	20	35310930	35310930	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:35310930G>A	uc002xfw.2	-	7	517	c.435C>T	c.(433-435)AGC>AGT	p.S145S	NDRG3_uc002xfx.2_Silent_p.S133S|NDRG3_uc010zvq.1_Silent_p.S50S|NDRG3_uc010zvr.1_Silent_p.S33S	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	145					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)																---	---	---	---
TOP1	7150	broad.mit.edu	37	20	39728804	39728804	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:39728804C>T	uc002xjl.2	+	12	1330	c.1084C>T	c.(1084-1086)CGT>TGT	p.R362C	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	362					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)			T	NUP98	AML*								---	---	---	---
CHD6	84181	broad.mit.edu	37	20	40034022	40034022	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:40034022A>G	uc002xka.1	-	37	7537	c.7359T>C	c.(7357-7359)GCT>GCC	p.A2453A	CHD6_uc002xjz.1_5'UTR	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2453					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)																---	---	---	---
CTSA	5476	broad.mit.edu	37	20	44527011	44527011	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:44527011C>T	uc002xqj.3	+	15	1839	c.1365C>T	c.(1363-1365)GCC>GCT	p.A455A	CTSA_uc002xqh.2_Silent_p.A473A|CTSA_uc002xqi.2_RNA|CTSA_uc010zxi.1_Silent_p.A456A|CTSA_uc002xqk.3_Silent_p.A455A	NM_001127695	NP_001121167	P10619	PPGB_HUMAN	cathepsin A isoform b precursor	455					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)																---	---	---	---
ARFGEF2	10564	broad.mit.edu	37	20	47630185	47630185	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:47630185G>A	uc002xtx.3	+	29	4155	c.4003G>A	c.(4003-4005)GAA>AAA	p.E1335K	ARFGEF2_uc010zyf.1_Missense_Mutation_p.E628K	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1335					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)															---	---	---	---
PTGIS	5740	broad.mit.edu	37	20	48156225	48156225	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:48156225C>T	uc002xut.2	-	5	609	c.555G>A	c.(553-555)GCG>GCA	p.A185A	PTGIS_uc010zyi.1_Silent_p.A46A	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	185					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)													---	---	---	---
MC3R	4159	broad.mit.edu	37	20	54824818	54824818	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:54824818C>T	uc002xxb.2	+	1	1031	c.919C>T	c.(919-921)CGC>TGC	p.R307C		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	344	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.R344C(1)		ovary(2)|breast(2)	4			Colorectal(105;0.202)															---	---	---	---
ZBP1	81030	broad.mit.edu	37	20	56190020	56190020	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:56190020C>T	uc002xyo.2	-	4	706	c.425G>A	c.(424-426)CGA>CAA	p.R142Q	ZBP1_uc010gjm.2_Missense_Mutation_p.R142Q|ZBP1_uc002xyp.2_Missense_Mutation_p.R67Q|ZBP1_uc010zzn.1_Missense_Mutation_p.R142Q	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	142	DRADA 2.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)															---	---	---	---
ZNF831	128611	broad.mit.edu	37	20	57767064	57767064	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:57767064G>T	uc002yan.2	+	1	990	c.990G>T	c.(988-990)AAG>AAT	p.K330N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	330						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)																	---	---	---	---
LAMA5	3911	broad.mit.edu	37	20	60887969	60887969	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60887969G>A	uc002ycq.2	-	66	9120	c.9053C>T	c.(9052-9054)CCG>CTG	p.P3018L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3018	Laminin G-like 2.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)													---	---	---	---
CABLES2	81928	broad.mit.edu	37	20	60966455	60966455	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:60966455C>T	uc002ycv.2	-	9	1153	c.1146G>A	c.(1144-1146)ACG>ACA	p.T382T		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	382					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)															---	---	---	---
DIDO1	11083	broad.mit.edu	37	20	61513747	61513747	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61513747C>T	uc002ydr.1	-	16	3825	c.3561G>A	c.(3559-3561)CCG>CCA	p.P1187P	DIDO1_uc002yds.1_Silent_p.P1187P	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1187					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)																	---	---	---	---
SLC17A9	63910	broad.mit.edu	37	20	61595621	61595621	+	Silent	SNP	G	A	A	rs147672643	by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:61595621G>A	uc002yea.3	+	8	1048	c.864G>A	c.(862-864)CCG>CCA	p.P288P	SLC17A9_uc002ydz.3_Silent_p.P282P|SLC17A9_uc011aap.1_Silent_p.P308P	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	288	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2																		---	---	---	---
KCNQ2	3785	broad.mit.edu	37	20	62065156	62065156	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62065156C>T	uc002yey.1	-						KCNQ2_uc002yez.1_Intron|KCNQ2_uc002yfa.1_Intron|KCNQ2_uc002yfb.1_Intron|KCNQ2_uc011aax.1_Intron|KCNQ2_uc002yfc.1_Missense_Mutation_p.R375H	NM_172107	NP_742105			potassium voltage-gated channel KQT-like protein						axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)													---	---	---	---
RTEL1	51750	broad.mit.edu	37	20	62305451	62305451	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr20:62305451G>A	uc002yfu.1	+						RTEL1_uc011abc.1_Intron|RTEL1_uc002yft.1_Intron|RTEL1_uc011abd.1_Intron|RTEL1_uc011abe.1_Intron|RTEL1_uc002yfw.2_Intron	NM_016434	NP_057518			regulator of telomere elongation helicase 1						DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)															---	---	---	---
NCAM2	4685	broad.mit.edu	37	21	22656690	22656690	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:22656690C>G	uc002yld.1	+	3	556	c.307C>G	c.(307-309)CAA>GAA	p.Q103E	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Missense_Mutation_p.Q128E	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	103	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)														---	---	---	---
ADAMTS1	9510	broad.mit.edu	37	21	28216622	28216622	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:28216622C>T	uc002ymf.2	-	1	1107	c.652G>A	c.(652-654)GAA>AAA	p.E218K		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	218					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)												OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
KRTAP19-3	337970	broad.mit.edu	37	21	31864263	31864263	+	Missense_Mutation	SNP	C	T	T	rs75692404	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:31864263C>T	uc002yog.1	-	1	13	c.13G>A	c.(13-15)GGC>AGC	p.G5S		NM_181609	NP_853640	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	5						intermediate filament					0																		---	---	---	---
DNAJC28	54943	broad.mit.edu	37	21	34861110	34861110	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34861110C>T	uc002yrv.2	-	2	1040	c.591G>A	c.(589-591)ACG>ACA	p.T197T	DNAJC28_uc002yrw.2_Silent_p.T197T	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	197							heat shock protein binding				0																		---	---	---	---
GART	2618	broad.mit.edu	37	21	34903056	34903056	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:34903056G>A	uc002yrx.2	-						GART_uc002yrz.2_Intron|GART_uc010gmd.2_Intron|GART_uc002yry.2_Intron|GART_uc002ysa.2_Intron	NM_000819	NP_000810			phosphoribosylglycinamide formyltransferase,						'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)													---	---	---	---
MORC3	23515	broad.mit.edu	37	21	37741742	37741742	+	Silent	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37741742A>G	uc002yvi.2	+	15	2152	c.2076A>G	c.(2074-2076)GCA>GCG	p.A692A		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	692	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2																		---	---	---	---
CLDN14	23562	broad.mit.edu	37	21	37833534	37833534	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37833534T>C	uc002yvk.1	-	2	602	c.460A>G	c.(460-462)AGC>GGC	p.S154G	CLDN14_uc002yvn.1_Missense_Mutation_p.S154G|CLDN14_uc002yvo.1_Missense_Mutation_p.S154G|CLDN14_uc002yvl.1_Missense_Mutation_p.S154G|CLDN14_uc002yvm.1_Missense_Mutation_p.S154G	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	154	Extracellular (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
CLDN14	23562	broad.mit.edu	37	21	37833611	37833611	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:37833611G>A	uc002yvk.1	-	2	525	c.383C>T	c.(382-384)GCC>GTC	p.A128V	CLDN14_uc002yvn.1_Missense_Mutation_p.A128V|CLDN14_uc002yvo.1_Missense_Mutation_p.A128V|CLDN14_uc002yvl.1_Missense_Mutation_p.A128V|CLDN14_uc002yvm.1_Missense_Mutation_p.A128V	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	128	Helical; (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0																		---	---	---	---
ETS2	2114	broad.mit.edu	37	21	40186201	40186201	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:40186201C>T	uc002yxg.2	+	4	385	c.189C>T	c.(187-189)TCC>TCT	p.S63S	ETS2_uc002yxf.2_Silent_p.S203S	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	63					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)																---	---	---	---
PRDM15	63977	broad.mit.edu	37	21	43231123	43231123	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43231123T>C	uc002yzq.1	-	27	3671	c.3560A>G	c.(3559-3561)AAG>AGG	p.K1187R	PRDM15_uc002yzo.2_Missense_Mutation_p.K858R|PRDM15_uc002yzp.2_Missense_Mutation_p.K878R|PRDM15_uc002yzr.1_Missense_Mutation_p.K878R	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1187	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0																		---	---	---	---
ZNF295	49854	broad.mit.edu	37	21	43411609	43411609	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:43411609C>T	uc002zab.3	-	3	2810	c.2596G>A	c.(2596-2598)GAA>AAA	p.E866K	ZNF295_uc002yzz.3_Missense_Mutation_p.E665K|ZNF295_uc002yzy.3_Missense_Mutation_p.E866K|ZNF295_uc002zaa.3_Missense_Mutation_p.E866K	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	866					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3																		---	---	---	---
LRRC3	81543	broad.mit.edu	37	21	45877042	45877042	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:45877042G>A	uc002zfa.2	+	2	808	c.515G>A	c.(514-516)TGC>TAC	p.C172Y		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	172						integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)														---	---	---	---
KRTAP10-12	386685	broad.mit.edu	37	21	46117692	46117692	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46117692C>T	uc002zfw.1	+	1	606	c.576C>T	c.(574-576)TCC>TCT	p.S192S	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198699	NP_941972	P60413	KR10C_HUMAN	keratin associated protein 10-12	192	18.|19 X 5 AA repeats of C-C-X(3).					keratin filament					0																		---	---	---	---
SUMO3	6612	broad.mit.edu	37	21	46233931	46233931	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:46233931G>A	uc002zfz.1	-	2	271	c.110C>T	c.(109-111)ACG>ATG	p.T37M	SUMO3_uc011afi.1_Missense_Mutation_p.T37M|SUMO3_uc002zga.1_Missense_Mutation_p.T37M	NM_006936	NP_008867	P55854	SUMO3_HUMAN	small ubiquitin-like modifier protein 3	37	Ubiquitin-like.				protein sumoylation	cytoplasm|kinetochore	protein binding				0				Colorectal(79;0.058)														---	---	---	---
COL6A2	1292	broad.mit.edu	37	21	47552299	47552299	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47552299C>T	uc002zia.1	+	28	2975	c.2893C>T	c.(2893-2895)CGC>TGC	p.R965C	COL6A2_uc002zib.1_Missense_Mutation_p.R371C|COL6A2_uc002zic.1_Silent_p.C39C|COL6A2_uc010gqe.1_RNA	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	965	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)														---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47663638	47663638	+	Splice_Site	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47663638T>C	uc002zir.1	-	24	5075	c.5039_splice	c.e24-1	p.A1680_splice	MCM3APAS_uc002zim.2_Intron|MCM3APAS_uc002zin.2_Intron|MCM3AP_uc002zio.1_Splice_Site_p.A175_splice|MCM3AP_uc002zip.1_Splice_Site_p.A421_splice|MCM3AP_uc002ziq.1_Splice_Site_p.A607_splice|MCM3APAS_uc002zis.1_Intron	NM_003906	NP_003897			minichromosome maintenance complex component 3						DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
MCM3AP	8888	broad.mit.edu	37	21	47686064	47686064	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47686064G>A	uc002zir.1	-	11	2842	c.2806C>T	c.(2806-2808)CGG>TGG	p.R936W	MCM3AP_uc002ziq.1_5'UTR	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	936					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)																	---	---	---	---
PCNT	5116	broad.mit.edu	37	21	47841990	47841990	+	Silent	SNP	G	A	A	rs142266651		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:47841990G>A	uc002zji.3	+	32	7238	c.7131G>A	c.(7129-7131)CCG>CCA	p.P2377P	PCNT_uc002zjj.2_Silent_p.P2259P	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	2377					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)																	---	---	---	---
PRMT2	3275	broad.mit.edu	37	21	48083456	48083456	+	Missense_Mutation	SNP	C	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr21:48083456C>G	uc002zjx.2	+	11	1573	c.1259C>G	c.(1258-1260)ACA>AGA	p.T420R	PRMT2_uc002zjy.2_Missense_Mutation_p.T420R|PRMT2_uc010gqm.2_Missense_Mutation_p.T318R|PRMT2_uc011aga.1_Missense_Mutation_p.H272Q|PRMT2_uc011agb.1_Intron|PRMT2_uc011agc.1_Intron	NM_206962	NP_996845	P55345	ANM2_HUMAN	HMT1 hnRNP methyltransferase-like 1	420					developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)														---	---	---	---
MICAL3	57553	broad.mit.edu	37	22	18379717	18379717	+	Nonsense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:18379717G>A	uc002zng.3	-	8	1332	c.979C>T	c.(979-981)CGA>TGA	p.R327*	MICAL3_uc011agl.1_Nonsense_Mutation_p.R327*|MICAL3_uc002znh.2_Nonsense_Mutation_p.R327*|MICAL3_uc002znj.1_Nonsense_Mutation_p.R27*|MICAL3_uc002znk.1_Nonsense_Mutation_p.R327*|MICAL3_uc002znl.1_5'UTR|MICAL3_uc010grf.2_Nonsense_Mutation_p.R327*	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	microtubule associated monoxygenase, calponin	327						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding				0		all_epithelial(15;0.198)		Lung(27;0.0427)												OREG0026285	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	---	---	---
MRPL40	64976	broad.mit.edu	37	22	19420868	19420868	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:19420868T>C	uc002zpg.2	+	2	176	c.134T>C	c.(133-135)ATG>ACG	p.M45T	HIRA_uc002zpf.1_5'Flank|HIRA_uc011agx.1_5'Flank|HIRA_uc010grn.1_5'Flank|HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zph.2_Missense_Mutation_p.M1T	NM_003776	NP_003767	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40 precursor	45					anatomical structure morphogenesis	mitochondrial ribosome|nucleus					0	Colorectal(54;0.0993)																	---	---	---	---
ZDHHC8	29801	broad.mit.edu	37	22	20130311	20130311	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20130311C>T	uc002zrq.2	+	10	1264	c.1158C>T	c.(1156-1158)GAC>GAT	p.D386D	ZDHHC8_uc002zrr.1_Silent_p.D386D|ZDHHC8_uc010gsa.2_Silent_p.D192D	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	386	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)																	---	---	---	---
MED15	51586	broad.mit.edu	37	22	20940112	20940112	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:20940112C>T	uc002zsp.2	+	17	2309	c.2229C>T	c.(2227-2229)TAC>TAT	p.Y743Y	MED15_uc002zsq.2_Silent_p.Y703Y|MED15_uc010gso.2_Silent_p.Y686Y|MED15_uc002zsr.2_Silent_p.Y677Y|MED15_uc011ahs.1_Silent_p.Y677Y|MED15_uc002zss.2_Silent_p.Y622Y|MED15_uc011ahu.1_Silent_p.Y453Y|MED15_uc002zst.2_Silent_p.Y359Y|MED15_uc002zsu.2_Silent_p.Y348Y	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	743					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)															---	---	---	---
PI4KA	5297	broad.mit.edu	37	22	21065106	21065106	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21065106G>A	uc002zsz.3	-	52	6021	c.5790C>T	c.(5788-5790)CTC>CTT	p.L1930L	PI4KA_uc010gsp.2_Silent_p.L321L|PI4KA_uc002zsy.3_Silent_p.L740L	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	1930	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)															---	---	---	---
SLC7A4	6545	broad.mit.edu	37	22	21385285	21385285	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:21385285C>T	uc002zud.2	-	2	885	c.817G>A	c.(817-819)GCC>ACC	p.A273T	SLC7A4_uc002zue.2_Missense_Mutation_p.A273T	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	273	Helical; (Potential).				cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)													---	---	---	---
MAPK1	5594	broad.mit.edu	37	22	22160224	22160224	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:22160224C>T	uc002zvn.2	-	3	647	c.407G>A	c.(406-408)GGG>GAG	p.G136E	MAPK1_uc002zvo.2_Missense_Mutation_p.G136E|MAPK1_uc010gtk.1_Missense_Mutation_p.G136E	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	136	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)													---	---	---	---
SMARCB1	6598	broad.mit.edu	37	22	24145518	24145518	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24145518C>T	uc002zyb.2	+	5	744	c.537C>T	c.(535-537)AAC>AAT	p.N179N	SMARCB1_uc002zya.2_Silent_p.N179N|SMARCB1_uc002zyc.2_Silent_p.N170N|SMARCB1_uc002zyd.2_Silent_p.N188N|SMARCB1_uc002zye.1_Silent_p.N105N|SMARCB1_uc002zyf.1_RNA|SMARCB1_uc010gue.1_RNA	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	179	DNA-binding (Potential).				cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(5)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)						D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				---	---	---	---
UPB1	51733	broad.mit.edu	37	22	24919664	24919664	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:24919664C>T	uc003aaf.2	+	9	1115	c.994C>T	c.(994-996)CGT>TGT	p.R332C	UPB1_uc003aae.2_Missense_Mutation_p.R264C|UPB1_uc011ajt.1_Missense_Mutation_p.R332C	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	332	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)																	---	---	---	---
TFIP11	24144	broad.mit.edu	37	22	26892177	26892177	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:26892177G>A	uc003acr.2	-	11	2085	c.1711C>T	c.(1711-1713)CGT>TGT	p.R571C	TFIP11_uc003acq.2_5'Flank|TFIP11_uc003acs.2_Missense_Mutation_p.R571C|TFIP11_uc003act.2_Missense_Mutation_p.R571C	NM_012143	NP_036275	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	571					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity				0																		---	---	---	---
MN1	4330	broad.mit.edu	37	22	28195374	28195374	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:28195374C>T	uc003adj.2	-	1	2113	c.1158G>A	c.(1156-1158)GCG>GCA	p.A386A		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	386							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10								T	ETV6	AML|meningioma								---	---	---	---
EWSR1	2130	broad.mit.edu	37	22	29668385	29668385	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:29668385G>A	uc003aet.2	+	3	395	c.67G>A	c.(67-69)GCC>ACC	p.A23T	EWSR1_uc003aes.3_Missense_Mutation_p.A23T|EWSR1_uc003aev.2_Missense_Mutation_p.A23T|EWSR1_uc003aew.2_Missense_Mutation_p.A23T|EWSR1_uc003aex.2_Missense_Mutation_p.A23T	NM_005243	NP_005234	Q01844	EWS_HUMAN	Ewing sarcoma breakpoint region 1 isoform 2	23	EAD (Gln/Pro/Thr-rich).|2.|31 X approximate tandem repeats.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/FLI1(2266)|EWSR1/ATF1(323)|EWSR1/WT1(231)|EWSR1/ERG(162)|EWSR1/NR4A3(140)|EWSR1/DDIT3(43)|EWSR1/CREB1(42)|EWSR1/FEV(10)|EWSR1/POU5F1(10)|EWSR1/ETV1(7)|EWSR1/ETV4(6)|EWSR1/ZNF384(4)|EWSR1/PBX1(3)|EWSR1/SP3(3)|EWSR1/PATZ1(2)	bone(2526)|soft_tissue(702)|skin(8)|autonomic_ganglia(4)|haematopoietic_and_lymphoid_tissue(4)|salivary_gland(2)|central_nervous_system(2)|NS(2)|pancreas(2)|lung(1)|ovary(1)	3254								T	FLI1|ERG|ZNF278|NR4A3|FEV|ATF1|ETV1|ETV4|WT1|ZNF384|CREB1|POU5F1| PBX1	Ewing sarcoma| desmoplastic small round cell tumor |ALL|clear cell sarcoma|sarcoma|myoepithelioma								---	---	---	---
PISD	23761	broad.mit.edu	37	22	32015765	32015765	+	Missense_Mutation	SNP	C	T	T	rs61747365		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32015765C>T	uc003alm.3	-	8	1070	c.1063G>A	c.(1063-1065)GTG>ATG	p.V355M	PISD_uc003alk.2_Missense_Mutation_p.V321M|PISD_uc003all.2_3'UTR|PISD_uc011alr.1_Missense_Mutation_p.V320M|PISD_uc003aln.3_Missense_Mutation_p.V317M	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	355					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)													---	---	---	---
SLC5A1	6523	broad.mit.edu	37	22	32462978	32462978	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:32462978C>T	uc003amc.2	+	3	496	c.264C>T	c.(262-264)GCC>GCT	p.A88A	SLC5A1_uc011alz.1_5'UTR	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	88	Extracellular (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1																		---	---	---	---
RBM9	23543	broad.mit.edu	37	22	36205885	36205885	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:36205885G>A	uc003aon.3	-	3	516	c.404C>T	c.(403-405)ACG>ATG	p.T135M	RBM9_uc003aog.3_Missense_Mutation_p.T45M|RBM9_uc003aol.3_Missense_Mutation_p.T65M|RBM9_uc003aoj.3_Missense_Mutation_p.T65M|RBM9_uc003aok.3_Missense_Mutation_p.T65M|RBM9_uc003aoh.3_Missense_Mutation_p.T65M|RBM9_uc003aom.3_Missense_Mutation_p.T65M|RBM9_uc010gwu.2_Missense_Mutation_p.T45M|RBM9_uc003aoo.3_Missense_Mutation_p.T135M|RBM9_uc003aop.3_Missense_Mutation_p.T65M	NM_001082578	NP_001076047	O43251	RFOX2_HUMAN	RNA binding motif protein 9 isoform 5	75					estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding				0																		---	---	---	---
CARD10	29775	broad.mit.edu	37	22	37912253	37912253	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:37912253C>T	uc003asx.1	-	3	429	c.426G>A	c.(424-426)CGG>CGA	p.R142R	CARD10_uc003ast.1_RNA|CARD10_uc003asy.1_Silent_p.R142R	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	142	Potential.				activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)																	---	---	---	---
BAIAP2L2	80115	broad.mit.edu	37	22	38484757	38484757	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:38484757G>A	uc003auw.2	-	10	1260	c.1116C>T	c.(1114-1116)TCC>TCT	p.S372S	BAIAP2L2_uc003auv.2_5'Flank	NM_025045	NP_079321	Q6UXY1	BI2L2_HUMAN	BAI1-associated protein 2-like 2	372	SH3.				filopodium assembly|signal transduction		cytoskeletal adaptor activity|SH3 domain binding			pancreas(1)	1	Melanoma(58;0.045)																	---	---	---	---
SUN2	25777	broad.mit.edu	37	22	39135931	39135931	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39135931C>T	uc003awh.1	-	14	1658	c.1374G>A	c.(1372-1374)CCG>CCA	p.P458P	SUN2_uc011anz.1_Silent_p.P493P|SUN2_uc011aoa.1_Silent_p.P447P|SUN2_uc003awi.1_Silent_p.P458P|SUN2_uc010gxq.1_Silent_p.P479P|SUN2_uc010gxr.1_Silent_p.P458P|SUN2_uc010gxs.1_Silent_p.P458P	NM_015374	NP_056189	Q9UH99	SUN2_HUMAN	unc-84 homolog B	458	Perinuclear space.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			large_intestine(1)|skin(1)	2																		---	---	---	---
TAB1	10454	broad.mit.edu	37	22	39817833	39817833	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:39817833G>A	uc003axt.2	+	8	827	c.778G>A	c.(778-780)GCT>ACT	p.A260T	TAB1_uc003axr.2_Missense_Mutation_p.A336T|TAB1_uc011aok.1_Missense_Mutation_p.A94T|TAB1_uc003axu.1_Missense_Mutation_p.A260T	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	260	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1																		---	---	---	---
CACNA1I	8911	broad.mit.edu	37	22	40074042	40074042	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:40074042G>A	uc003ayc.2	+	31	4984	c.4984G>A	c.(4984-4986)GAG>AAG	p.E1662K	CACNA1I_uc003ayd.2_Missense_Mutation_p.E1627K|CACNA1I_uc003aye.2_Missense_Mutation_p.E1577K|CACNA1I_uc003ayf.2_Missense_Mutation_p.E1542K	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1662	Extracellular (Potential).|IV.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)													---	---	---	---
MCHR1	2847	broad.mit.edu	37	22	41077720	41077720	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41077720C>T	uc003ayz.2	+	2	1325	c.1057C>T	c.(1057-1059)CGC>TGC	p.R353C	MCHR1_uc003aza.2_Missense_Mutation_p.R242C|uc003azb.1_RNA	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	353	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0																		---	---	---	---
ZC3H7B	23264	broad.mit.edu	37	22	41745119	41745119	+	Intron	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:41745119G>A	uc003azw.2	+						ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060			zinc finger CCCH-type containing 7B						interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1																		---	---	---	---
CYP2D6	1565	broad.mit.edu	37	22	42523877	42523877	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:42523877G>T	uc003bce.2	-	6	1042	c.952C>A	c.(952-954)CTC>ATC	p.L318I	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Missense_Mutation_p.L12I|CYP2D6_uc003bcf.2_Missense_Mutation_p.L267I	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	318							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2																		---	---	---	---
FAM118A	55007	broad.mit.edu	37	22	45719294	45719294	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45719294C>T	uc003bfz.3	+	4	902	c.286C>T	c.(286-288)CGG>TGG	p.R96W	FAM118A_uc003bga.3_Missense_Mutation_p.R96W	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	96						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)														---	---	---	---
FBLN1	2192	broad.mit.edu	37	22	45996196	45996196	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:45996196G>A	uc003bgj.1	+	17	2129	c.1982G>A	c.(1981-1983)CGC>CAC	p.R661H	FBLN1_uc003bgk.1_RNA	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	661					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)														---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46930415	46930415	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46930415C>T	uc003bhw.1	-	1	2653	c.2653G>A	c.(2653-2655)GCC>ACC	p.A885T		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	885	Extracellular (Potential).|Cadherin 6.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
CELSR1	9620	broad.mit.edu	37	22	46931760	46931760	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:46931760C>T	uc003bhw.1	-	1	1308	c.1308G>A	c.(1306-1308)CCG>CCA	p.P436P		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	436	Extracellular (Potential).|Cadherin 2.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)														---	---	---	---
TTLL8	164714	broad.mit.edu	37	22	50470410	50470410	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chr22:50470410C>T	uc011ark.1	-	11	1412	c.1412G>A	c.(1411-1413)CGT>CAT	p.R471H		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)														---	---	---	---
PPP2R3B	28227	broad.mit.edu	37	X	306382	306382	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:306382G>A	uc004cpg.2	-	7	1106	c.905C>T	c.(904-906)GCG>GTG	p.A302V	PPP2R3B_uc011mha.1_Missense_Mutation_p.A141V	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	302					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
SFRS17A	8227	broad.mit.edu	37	X	1714399	1714399	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:1714399G>A	uc004cqa.2	+	3	1081	c.885G>A	c.(883-885)GCG>GCA	p.A295A	SFRS17A_uc010ncx.1_Silent_p.A295A|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'UTR	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	295					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)																---	---	---	---
PIGA	5277	broad.mit.edu	37	X	15349630	15349630	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:15349630G>A	uc004cwr.2	-	2	523	c.423C>T	c.(421-423)CAC>CAT	p.H141H	PIGA_uc004cwq.2_Intron|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Intron	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	141	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)																	---	---	---	---
PHKA2	5256	broad.mit.edu	37	X	18912415	18912415	+	Silent	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:18912415C>T	uc004cyv.3	-	32	3874	c.3444G>A	c.(3442-3444)ACG>ACA	p.T1148T	uc004cyt.2_RNA|PHKA2_uc004cyu.3_Silent_p.T454T|PHKA2_uc010nfe.1_Silent_p.T180T|PHKA2_uc010nff.1_RNA	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1148					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)																	---	---	---	---
MAGEB4	4115	broad.mit.edu	37	X	30260314	30260314	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:30260314A>G	uc004dcb.2	+	1	146	c.62A>G	c.(61-63)CAG>CGG	p.Q21R	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	21										ovary(1)	1																		---	---	---	---
FTHL17	53940	broad.mit.edu	37	X	31090062	31090062	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:31090062G>A	uc004dcl.1	-	1	112	c.9C>T	c.(7-9)ACC>ACT	p.T3T		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	3					cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0																		---	---	---	---
RPGR	6103	broad.mit.edu	37	X	38134335	38134335	+	Intron	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:38134335C>T	uc004deb.2	-						RPGR_uc004dea.2_Intron|RPGR_uc004dec.2_Intron	NM_000328	NP_000319			retinitis pigmentosa GTPase regulator isoform A						intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1																		---	---	---	---
PHF16	9767	broad.mit.edu	37	X	46884163	46884163	+	Nonsense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:46884163C>T	uc004dgx.2	+	5	373	c.322C>T	c.(322-324)CGA>TGA	p.R108*	PHF16_uc004dgy.2_Nonsense_Mutation_p.R108*	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	108					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0																		---	---	---	---
CFP	5199	broad.mit.edu	37	X	47486543	47486543	+	Missense_Mutation	SNP	G	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:47486543G>T	uc004dig.3	-	5	889	c.763C>A	c.(763-765)CCA>ACA	p.P255T	CFP_uc004dih.2_Missense_Mutation_p.P255T|CFP_uc004dii.1_Missense_Mutation_p.P191T|CFP_uc010nhu.2_Missense_Mutation_p.P255T	NM_001145252	NP_001138724	P27918	PROP_HUMAN	complement factor properdin precursor	255	TSP type-1 3.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(2)|lung(1)	3																		---	---	---	---
KCND1	3750	broad.mit.edu	37	X	48820066	48820066	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:48820066G>A	uc004dlx.1	-	6	3293	c.1720C>T	c.(1720-1722)CGC>TGC	p.R574C	KCND1_uc004dlw.1_Missense_Mutation_p.R197C	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	574	Cytoplasmic (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3																		---	---	---	---
PPP1R3F	89801	broad.mit.edu	37	X	49142650	49142650	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:49142650C>T	uc004dnh.1	+	4	1514	c.1498C>T	c.(1498-1500)CGG>TGG	p.R500W	PPP1R3F_uc011mnd.1_Missense_Mutation_p.R171W|PPP1R3F_uc004dni.2_Missense_Mutation_p.R154W|PPP1R3F_uc004dnj.1_Missense_Mutation_p.R154W	NM_033215	NP_149992	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory (inhibitor)	500	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3	Ovarian(276;0.236)																	---	---	---	---
FOXO4	4303	broad.mit.edu	37	X	70321551	70321551	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70321551A>G	uc004dys.1	+	2	1824	c.1471A>G	c.(1471-1473)ATG>GTG	p.M491V	FOXO4_uc010nkz.2_Intron|FOXO4_uc004dyt.1_Missense_Mutation_p.M436V	NM_005938	NP_005929	P98177	FOXO4_HUMAN	forkhead box O4	491					cell cycle arrest|cell differentiation|embryo development|G1 phase of mitotic cell cycle|insulin receptor signaling pathway|mitotic cell cycle G2/M transition DNA damage checkpoint|muscle organ development|negative regulation of angiogenesis|negative regulation of cell proliferation|negative regulation of smooth muscle cell differentiation|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(2)|prostate(1)	3	Renal(35;0.156)																	---	---	---	---
MED12	9968	broad.mit.edu	37	X	70341606	70341606	+	Silent	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:70341606T>C	uc004dyy.2	+	7	1240	c.1041T>C	c.(1039-1041)AGT>AGC	p.S347S	MED12_uc011mpq.1_Silent_p.S347S|MED12_uc004dyz.2_Silent_p.S347S|MED12_uc004dza.2_Silent_p.S194S	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	347					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)																	---	---	---	---
NAP1L2	4674	broad.mit.edu	37	X	72434173	72434173	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:72434173G>A	uc004ebi.2	-	1	512	c.156C>T	c.(154-156)GCC>GCT	p.A52A	NAP1L2_uc011mqj.1_Intron	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	52					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)																	---	---	---	---
ATRX	546	broad.mit.edu	37	X	76938923	76938923	+	Missense_Mutation	SNP	G	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:76938923G>C	uc004ecp.3	-	9	2057	c.1825C>G	c.(1825-1827)CCA>GCA	p.P609A	ATRX_uc004ecq.3_Missense_Mutation_p.P571A|ATRX_uc004eco.3_Missense_Mutation_p.P394A|ATRX_uc004ecr.2_Missense_Mutation_p.P541A|ATRX_uc010nlx.1_Missense_Mutation_p.P580A|ATRX_uc010nly.1_Missense_Mutation_p.P554A	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	609					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						---	---	---	---
ATP7A	538	broad.mit.edu	37	X	77253979	77253979	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:77253979G>A	uc004ecx.3	+	5	1501	c.1341G>A	c.(1339-1341)ACG>ACA	p.T447T	ATP7A_uc004ecw.2_Silent_p.T447T	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	447	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0																		---	---	---	---
POU3F4	5456	broad.mit.edu	37	X	82764008	82764008	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:82764008G>A	uc004eeg.2	+	1	740	c.676G>A	c.(676-678)GTG>ATG	p.V226M		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	226	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1																		---	---	---	---
TGIF2LX	90316	broad.mit.edu	37	X	89177144	89177144	+	Silent	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:89177144G>A	uc004efe.2	+	2	109	c.60G>A	c.(58-60)CCG>CCA	p.P20P		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	20						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2																		---	---	---	---
DRP2	1821	broad.mit.edu	37	X	100496692	100496692	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:100496692C>T	uc004egz.2	+	7	964	c.595C>T	c.(595-597)CGC>TGC	p.R199C	DRP2_uc011mrh.1_Missense_Mutation_p.R121C	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	199					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2																		---	---	---	---
CHRDL1	91851	broad.mit.edu	37	X	109937472	109937472	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:109937472G>A	uc004eou.3	-	8	1046	c.697C>T	c.(697-699)CGG>TGG	p.R233W	CHRDL1_uc004eov.2_Missense_Mutation_p.R227W|CHRDL1_uc004eow.2_Missense_Mutation_p.R232W|CHRDL1_uc010nps.2_Missense_Mutation_p.R232W|CHRDL1_uc004eot.2_Missense_Mutation_p.R153W|CHRDL1_uc011mss.1_Missense_Mutation_p.R147W	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	226					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0																		---	---	---	---
CD40LG	959	broad.mit.edu	37	X	135741286	135741286	+	Missense_Mutation	SNP	A	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:135741286A>C	uc004faa.2	+	5	570	c.498A>C	c.(496-498)CAA>CAC	p.Q166H	CD40LG_uc010nsd.2_Missense_Mutation_p.Q145H	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	166	Extracellular (Potential).				anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)									Immune_Deficiency_with_Hyper-IgM				---	---	---	---
GPR101	83550	broad.mit.edu	37	X	136113077	136113077	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:136113077T>C	uc011mwh.1	-	1	757	c.757A>G	c.(757-759)AAG>GAG	p.K253E		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	253	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)																	---	---	---	---
AFF2	2334	broad.mit.edu	37	X	148037756	148037756	+	Silent	SNP	C	A	A	rs143927826	byFrequency;by1000genomes	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:148037756C>A	uc004fcp.2	+	11	2660	c.2181C>A	c.(2179-2181)ACC>ACA	p.T727T	AFF2_uc004fcq.2_Silent_p.T717T|AFF2_uc004fcr.2_Silent_p.T688T|AFF2_uc011mxb.1_Silent_p.T692T|AFF2_uc004fcs.2_Silent_p.T694T|AFF2_uc011mxc.1_Silent_p.T368T	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	727					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
GPR50	9248	broad.mit.edu	37	X	150345291	150345291	+	Missense_Mutation	SNP	G	A	A			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150345291G>A	uc010ntg.1	+	1	233	c.98G>A	c.(97-99)TGC>TAC	p.C33Y	uc004fes.1_RNA|GPR50_uc011myc.1_Missense_Mutation_p.C33Y	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	33	Helical; Name=1; (Potential).				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
PASD1	139135	broad.mit.edu	37	X	150817164	150817164	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:150817164C>T	uc004fev.3	+	9	1039	c.707C>T	c.(706-708)GCT>GTT	p.A236V		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
MAGEA12	4111	broad.mit.edu	37	X	151900304	151900304	+	Missense_Mutation	SNP	A	G	G			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:151900304A>G	uc010ntp.2	-	3	851	c.497T>C	c.(496-498)GTG>GCG	p.V166A	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.V166A|CSAG1_uc004fge.2_5'Flank|CSAG1_uc004fgf.2_5'Flank|CSAG1_uc004fgd.2_5'Flank	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	166	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ATP2B3	492	broad.mit.edu	37	X	152801812	152801812	+	Missense_Mutation	SNP	C	T	T			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:152801812C>T	uc004fht.1	+	1	233	c.107C>T	c.(106-108)ACC>ATC	p.T36I	ATP2B3_uc004fhs.1_Missense_Mutation_p.T36I	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	36	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
ARHGAP4	393	broad.mit.edu	37	X	153175645	153175645	+	Silent	SNP	C	T	T	rs141995493	byFrequency	TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153175645C>T	uc004fjk.1	-	17	2178	c.2136G>A	c.(2134-2136)CCG>CCA	p.P712P	ARHGAP4_uc004fjj.1_Silent_p.P63P|ARHGAP4_uc011mzf.1_Silent_p.P689P|ARHGAP4_uc004fjl.1_Silent_p.P752P|ARHGAP4_uc010nup.1_Intron	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	712					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)																	---	---	---	---
OPN1LW	5956	broad.mit.edu	37	X	153421852	153421852	+	Silent	SNP	G	A	A	rs2315125		TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153421852G>A	uc004fjz.3	+	5	861	c.828G>A	c.(826-828)GCG>GCA	p.A276A		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	276	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
G6PD	2539	broad.mit.edu	37	X	153762274	153762274	+	Missense_Mutation	SNP	T	C	C			TCGA-F1-6177-01A-11D-1800-08	TCGA-F1-6177-10A-01D-1800-08									Somatic	Phase_I	Capture				Illumina GAIIx	g.chrX:153762274T>C	uc004fly.1	-	7	859	c.746A>G	c.(745-747)TAT>TGT	p.Y249C	G6PD_uc004flx.1_Missense_Mutation_p.Y279C	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	249					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)																	---	---	---	---
