Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GNL2	29889	broad.mit.edu	37	1	38032588	38032588	+	Silent	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:38032588C>T	uc001cbk.2	-	16	2227	c.2064G>A	c.(2062-2064)CAG>CAA	p.Q688Q		NM_013285	NP_037417	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2	688					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)				TCGGCCGTTGCTGTCGTACTG	0.418000													7	379					0	0	0.029380	0	0
LEPRE1	64175	broad.mit.edu	37	1	43213400	43213400	+	Silent	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:43213400G>T	uc001chv.2	-	13	2021	c.1908C>A	c.(1906-1908)ACC>ACA	p.T636T	LEPRE1_uc001chw.2_Silent_p.T636T|LEPRE1_uc001chx.3_Silent_p.T636T	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	636	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TCACCGTCACGGTCTTGGCAT	0.483000											OREG0013422	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	716					3.28513e-13	3.55059e-13	0.021523	1	0
MKNK1	8569	broad.mit.edu	37	1	47037819	47037819	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:47037819G>T	uc001cqb.2	-	7	653	c.409C>A	c.(409-411)CAG>AAG	p.Q137K	MKNK1_uc010omd.1_Missense_Mutation_p.Q42K|MKNK1_uc001cqc.2_Missense_Mutation_p.Q137K|MKNK1_uc009vyi.2_Missense_Mutation_p.Q137K|MKNK1_uc010ome.1_Missense_Mutation_p.Q42K|MKNK1_uc009vyj.2_Missense_Mutation_p.Q82K|MKNK1_uc001cqd.2_Missense_Mutation_p.Q125K	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	137	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					TTTTGCTTCTGGATGTGGGCT	0.458000													27	161					7.38237e-10	7.82092e-10	0.030593	1	0
LPAR3	23566	broad.mit.edu	37	1	85331647	85331647	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:85331647C>T	uc001dkl.2	-	1	196	c.157G>A	c.(157-159)GCG>ACG	p.A53T	LPAR3_uc009wcj.1_Missense_Mutation_p.A53T	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	53	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						ATCACTGCCGCGATGACCAGA	0.403000													59	441					0	0	0.014410	0	0
SARS	6301	broad.mit.edu	37	1	109771003	109771003	+	Silent	SNP	T	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:109771003T>A	uc001dwu.1	+	3	312	c.237T>A	c.(235-237)TCT>TCA	p.S79S	SARS_uc001dwt.1_Silent_p.S79S|SARS_uc001dwv.1_Silent_p.S79S|SARS_uc001dww.1_Silent_p.S12S|SARS_uc001dwx.1_Silent_p.S79S|SARS_uc009wfa.1_Silent_p.S79S|SARS_uc001dwy.1_5'UTR|SARS_uc001dwz.1_5'Flank	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	79					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	ATGATGAGTCTGTCCCAGAGA	0.368000													58	350					0	0	0.014410	0	0
RFWD2	64326	broad.mit.edu	37	1	175916332	175916332	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:175916332T>A	uc001gku.1	-	19	2433	c.2177A>T	c.(2176-2178)AAG>ATG	p.K726M	RFWD2_uc001gkv.1_Missense_Mutation_p.K702M|RFWD2_uc001gkw.1_Missense_Mutation_p.K486M|RFWD2_uc009wwv.2_Missense_Mutation_p.K525M|RFWD2_uc001gkt.1_Missense_Mutation_p.K565M	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	726	WD 7.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ATAGCTTACCTTAATTGTACC	0.373000													94	613					0	0	0.014410	0	0
FANK1	92565	broad.mit.edu	37	10	127668733	127668733	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr10:127668733T>G	uc001ljh.3	+	2	121	c.17T>G	c.(16-18)ATC>AGC	p.I6S	FANK1_uc010quk.1_5'UTR|FANK1_uc009yan.2_Missense_Mutation_p.I6S|FANK1_uc001lji.2_5'UTR	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	6						cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				TTTTTAGAAATCATGCCACCC	0.453000													30	133					0	0	0.009535	0	0
CWF19L2	143884	broad.mit.edu	37	11	107200701	107200701	+	Silent	SNP	G	A	A	rs138541383		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr11:107200701G>A	uc010rvp.1	-	17	2514	c.2484C>T	c.(2482-2484)CAC>CAT	p.H828H	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	828							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		CAAACCCTCCGTGAAGGCCAA	0.388000													4	45					0	0	0.021553	0	0
LRTM2	654429	broad.mit.edu	37	12	1943729	1943729	+	Missense_Mutation	SNP	G	A	A	rs140567368		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr12:1943729G>A	uc001qjt.2	+	5	1761	c.955G>A	c.(955-957)GGC>AGC	p.G319S	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Missense_Mutation_p.G319S|LRTM2_uc010sdx.1_Missense_Mutation_p.G319S|LRTM2_uc001qjv.2_Missense_Mutation_p.G81S	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	319	Helical; (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GGTCGTGTGCGGCGTCGTCTG	0.662000													24	192					0	0	0.030593	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	G	G	rs121913530		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr12:25398285C>G	uc001rgp.1	-	2	215	c.34G>C	c.(34-36)GGT>CGT	p.G12R	KRAS_uc001rgq.1_Missense_Mutation_p.G12R|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	95					0	0	0.003080	0	0
METTL7A	25840	broad.mit.edu	37	12	51319148	51319148	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr12:51319148G>T	uc001rxb.2	+	1	615	c.327G>T	c.(325-327)AAG>AAT	p.K109N	METTL7A_uc010smv.1_Intron	NM_014033	NP_054752	Q9H8H3	MET7A_HUMAN	methyltransferase like 7A precursor	109						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity				0						TTTTGATCAAGAGCATTGCAG	0.552000													60	311					6.20203e-27	7.05976e-27	0.014410	1	0
KNTC1	9735	broad.mit.edu	37	12	123082387	123082387	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr12:123082387C>T	uc001ucv.2	+	44	4628	c.4465C>T	c.(4465-4467)CGG>TGG	p.R1489W	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1489					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CTCTGCAAAGCGGCGGCATCC	0.502000													14	346					0	0	0.016723	0	0
LOC284232	284232	broad.mit.edu	37	13	19415783	19415783	+	RNA	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr13:19415783G>A	uc010tcj.1	-	1		c.30327C>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AGCAGCAGAAGATGTACTATG	0.299000													4	205					0	0	0.014758	0	0
PCDH17	27253	broad.mit.edu	37	13	58240934	58240934	+	Missense_Mutation	SNP	A	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr13:58240934A>T	uc001vhq.1	+	3	3656	c.2764A>T	c.(2764-2766)ACT>TCT	p.T922S	PCDH17_uc010aec.1_Missense_Mutation_p.T921S|PCDH17_uc001vhr.1_Missense_Mutation_p.T11S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	922	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAAGATGAAAACTACTTCAAC	0.438000													27	123					0	0	0.027356	0	0
KLF12	11278	broad.mit.edu	37	13	74269773	74269773	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr13:74269773T>C	uc001vjf.2	-	8	1285	c.1063A>G	c.(1063-1065)ACC>GCC	p.T355A	KLF12_uc010aeq.2_Missense_Mutation_p.T355A	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	355	C2H2-type 2.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		AACTTCCAGGTGCAGCCTTCC	0.512000													111	243					0	0	0.014410	0	0
FAM155A	728215	broad.mit.edu	37	13	108518661	108518661	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr13:108518661T>C	uc001vql.2	-	1	800	c.284A>G	c.(283-285)CAG>CGG	p.Q95R		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	95	Poly-Gln.					integral to membrane	binding			skin(1)	1						ctgccgccgctgctgctgctg	0.413000													3	78					0	0	0.004672	0	0
OR10G3	26533	broad.mit.edu	37	14	22038047	22038047	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038047G>T	uc010tmb.1	-	1	829	c.829C>A	c.(829-831)CCC>ACC	p.P277T		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		ATGGCCGTGGGGACTAGGGCA	0.567000													44	376					1.02687e-29	1.19429e-29	0.013114	1	0
OR10G3	26533	broad.mit.edu	37	14	22038238	22038238	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038238G>T	uc010tmb.1	-	1	638	c.638C>A	c.(637-639)TCC>TAC	p.S213Y		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GAGGATCAGGGAGAAGCAACT	0.537000													56	405					6.56871e-35	7.72365e-35	0.014410	1	0
OR10G3	26533	broad.mit.edu	37	14	22038389	22038389	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038389G>A	uc010tmb.1	-	1	487	c.487C>T	c.(487-489)CTA>TTA	p.L163L		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		CGGAAGGTTAGGATGGCCTGG	0.582000													47	301					0	0	0.014410	0	0
OR10G3	26533	broad.mit.edu	37	14	22038460	22038460	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038460G>C	uc010tmb.1	-	1	416	c.416C>G	c.(415-417)GCT>GGT	p.A139G		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GCTCAGCTTAGCAGTCATGAG	0.602000													17	188					0	0	0.008871	0	0
OR10G3	26533	broad.mit.edu	37	14	22038606	22038606	+	Silent	SNP	G	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038606G>C	uc010tmb.1	-	1	270	c.270C>G	c.(268-270)GTC>GTG	p.V90V		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GGATGGGTTTGACACCTAAAG	0.488000													16	168					0	0	0.028581	0	0
OR10G3	26533	broad.mit.edu	37	14	22038729	22038729	+	Silent	SNP	G	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038729G>C	uc010tmb.1	-	1	147	c.147C>G	c.(145-147)GTC>GTG	p.V49V		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GGTCTGCCCAGACAGTGATTA	0.463000													6	145					0	0	0.016723	0	0
OR10G3	26533	broad.mit.edu	37	14	22038761	22038761	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038761G>A	uc010tmb.1	-	1	115	c.115C>T	c.(115-117)CAG>TAG	p.Q39*		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		TTTCCCAGCTGAGTCAGGATG	0.453000													13	152					0	0	0.010504	0	0
OR10G3	26533	broad.mit.edu	37	14	22038779	22038779	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038779G>C	uc010tmb.1	-	1	97	c.97C>G	c.(97-99)CTA>GTA	p.L33V		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		ATGTAGATTAGAAAAAAGAAC	0.453000													10	157					0	0	0.018920	0	0
OR10G3	26533	broad.mit.edu	37	14	22038824	22038824	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038824G>T	uc010tmb.1	-	1	52	c.52C>A	c.(52-54)CCG>ACG	p.P18T		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		AGTGGATACGGAATTCCTGTC	0.403000													14	159					5.61819e-17	6.19738e-17	0.027356	1	0
OR10G3	26533	broad.mit.edu	37	14	22038837	22038837	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038837G>A	uc010tmb.1	-	1	39	c.39C>T	c.(37-39)ATC>ATT	p.I13I		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		TTCCTGTCAGGATAAACGCAG	0.393000													14	160					0	0	0.027356	0	0
MYH7	4625	broad.mit.edu	37	14	23886191	23886191	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:23886191G>A	uc001wjx.2	-	33	4636	c.4530C>T	c.(4528-4530)TCC>TCT	p.S1510S		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1510	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CAGTCAAGTCGGAGATCTCCT	0.587000													47	377					0	0	0.014410	0	0
CPNE6	9362	broad.mit.edu	37	14	24543770	24543770	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:24543770G>A	uc001wll.2	+	6	628	c.529G>A	c.(529-531)GAA>AAA	p.E177K	CPNE6_uc010tnv.1_Missense_Mutation_p.E232K|CPNE6_uc001wlm.2_Missense_Mutation_p.E2K|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	177	C2 2.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CCCTTTCATGGAAATCTATAA	0.532000													50	306					0	0	0.014410	0	0
CPNE6	9362	broad.mit.edu	37	14	24543774	24543774	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:24543774T>A	uc001wll.2	+	6	632	c.533T>A	c.(532-534)ATC>AAC	p.I178N	CPNE6_uc010tnv.1_Missense_Mutation_p.I233N|CPNE6_uc001wlm.2_Missense_Mutation_p.I3N|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	178	C2 2.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		TTCATGGAAATCTATAAGACC	0.522000													53	316					0	0	0.014410	0	0
SPTB	6710	broad.mit.edu	37	14	65268976	65268976	+	Silent	SNP	C	T	T	rs140370547	by1000genomes	TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:65268976C>T	uc001xht.2	-	4	588	c.534G>A	c.(532-534)GCG>GCA	p.A178A	SPTB_uc001xhr.2_Silent_p.A178A|SPTB_uc001xhs.2_Silent_p.A178A|SPTB_uc001xhu.2_Silent_p.A178A	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	178	Actin-binding.|CH 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		ACAACAGCAACGCATCCTTGG	0.537000											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	115					0	0	0.037714	0	0
SLC12A1	6557	broad.mit.edu	37	15	48500249	48500249	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr15:48500249G>T	uc001zwn.3	+	2	549	c.333G>T	c.(331-333)AAG>AAT	p.K111N	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Missense_Mutation_p.K111N|SLC12A1_uc010uex.1_Missense_Mutation_p.K111N	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	111	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CCGTTCCCAAGATAGAGTACT	0.473000													65	318					9.40535e-28	1.08212e-27	0.014410	1	0
VWA3A	146177	broad.mit.edu	37	16	22161156	22161156	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr16:22161156G>A	uc010vbq.1	+	29	3129	c.3033G>A	c.(3031-3033)ACG>ACA	p.T1011T	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Silent_p.T89T|VWA3A_uc010bxe.1_Silent_p.T113T	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1011	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GGCAGGACACGCTGGTGGAGA	0.547000													5	62					0	0	0.021553	0	0
NOD2	64127	broad.mit.edu	37	16	50750826	50750826	+	Silent	SNP	C	T	T	rs144083291		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr16:50750826C>T	uc002egm.1	+	6	2676	c.2571C>T	c.(2569-2571)GAC>GAT	p.D857D	NOD2_uc010cbl.1_Intron|NOD2_uc010cbm.1_Silent_p.D635D|NOD2_uc010cbn.1_Intron|NOD2_uc010cbo.1_Intron|NOD2_uc010cbp.1_Intron|NOD2_uc010cbq.1_Translation_Start_Site|NOD2_uc010cbr.1_Intron|NOD2_uc010vgq.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	857	LRR 3.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				AATTGACTGACGGCTGTGCAC	0.478000													14	678					0	0	0.016723	0	0
MLYCD	23417	broad.mit.edu	37	16	83948728	83948728	+	Silent	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr16:83948728C>T	uc002fgz.2	+	5	1136	c.1116C>T	c.(1114-1116)AAC>AAT	p.N372N		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor	372					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						GCCCCATTAACGAGACCCTCA	0.572000													82	486					0	0	0.014410	0	0
CDK10	8558	broad.mit.edu	37	16	89758916	89758916	+	Silent	SNP	T	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr16:89758916T>C	uc010cio.2	+	6	520	c.477T>C	c.(475-477)ATT>ATC	p.I159I	CDK10_uc010cip.2_Silent_p.I88I|CDK10_uc010vpl.1_Silent_p.I153I|CDK10_uc002fob.2_Silent_p.I88I|CDK10_uc002fod.2_Silent_p.I88I|CDK10_uc002foe.2_Silent_p.I88I|CDK10_uc002fof.2_Silent_p.I88I|CDK10_uc002fog.3_Silent_p.I88I|CDK10_uc002foh.3_Silent_p.I88I|CDK10_uc002foi.2_5'Flank	NM_052988	NP_443714	Q15131	CDK10_HUMAN	cyclin-dependent kinase 10 isoform a	159	Protein kinase.				negative regulation of cell proliferation|traversing start control point of mitotic cell cycle		ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(1)	1		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0276)		GGAACTTCATTATCCACAGGT	0.567000													53	260					0	0	0.014410	0	0
TP53	7157	broad.mit.edu	37	17	7577141	7577141	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:7577141C>A	uc002gim.2	-	8	991	c.797G>T	c.(796-798)GGA>GTA	p.G266V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.G266V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G134V|TP53_uc010cng.1_Missense_Mutation_p.G134V|TP53_uc002gii.1_Missense_Mutation_p.G134V|TP53_uc010cnh.1_Missense_Mutation_p.G266V|TP53_uc010cni.1_Missense_Mutation_p.G266V|TP53_uc002gij.2_Missense_Mutation_p.G266V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	266	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		G -> R (in sporadic cancers; somatic mutation).|G -> V (in sporadic cancers; somatic mutation).|G -> E (in sporadic cancers; somatic mutation).|G -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G266E(45)|p.G266R(42)|p.G266V(32)|p.G266*(12)|p.0?(7)|p.G266fs*79(5)|p.?(3)|p.G262_F270delGNLLGRNSF(2)|p.G266A(2)|p.G266G(2)|p.G266_E271delGRNSFE(2)|p.G262_S269delGNLLGRNS(2)|p.G266fs*4(1)|p.G266T(1)|p.L265_K305del41(1)|p.E258fs*71(1)|p.G266fs*9(1)|p.L265_R267delLGR(1)|p.G266_N268delGRN(1)|p.G262fs*2(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGTTCCGTCCCAGTAGATT	0.517000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	76					0.000151284	0.00015716	0.016723	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319402	21319402	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:21319402G>A	uc002gyv.1	+	3	1453	c.748G>A	c.(748-750)GAC>AAC	p.D250N		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	250	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	GGACCAGATCGACATCGATGT	0.612000										Prostate(3;0.18)			13	185					0	0	0.020292	0	0
GAS2L2	246176	broad.mit.edu	37	17	34077157	34077157	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:34077157T>G	uc002hjv.1	-	2	594	c.566A>C	c.(565-567)GAC>GCC	p.D189A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	189					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CGGCGAGGGGTCGGGCGGGGG	0.741000													23	202					0	0	0.019004	0	0
KRT15	3866	broad.mit.edu	37	17	39673185	39673185	+	Missense_Mutation	SNP	C	T	T	rs138271368		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:39673185C>T	uc002hwy.2	-	3	804	c.613G>A	c.(613-615)GTT>ATT	p.V205I	KRT15_uc002hwz.2_Missense_Mutation_p.V107I|KRT15_uc002hxa.2_Missense_Mutation_p.V40I|KRT15_uc002hxb.1_Missense_Mutation_p.V40I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	205	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCAGCCTCAACGCCCTGGCGC	0.612000													57	345					0	0	0.014410	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473626	43473626	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:43473626C>T	uc002iix.2	-	14	1624	c.1175G>A	c.(1174-1176)CGC>CAC	p.R392H	ARHGAP27_uc010dak.2_Missense_Mutation_p.R365H	NM_199282	NP_954976	Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27 isoform a	733	Rho-GAP.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding				0	Renal(3;0.0405)					TCCACTGATGCGGTACAGCCC	0.657000													4	203					0	0	0.009096	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47233957	47233957	+	Missense_Mutation	SNP	G	A	A	rs149941656		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:47233957G>A	uc002ion.2	+	5	729	c.670G>A	c.(670-672)GTC>ATC	p.V224I	B4GALNT2_uc010wlt.1_Missense_Mutation_p.V138I|B4GALNT2_uc010wlu.1_Missense_Mutation_p.V164I	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	224	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CGATGCCCCCGTCTATGAGGT	0.572000													64	396					0	0	0.014410	0	0
SCPEP1	59342	broad.mit.edu	37	17	55075816	55075816	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr17:55075816C>G	uc002iuv.3	+	10	1004	c.951C>G	c.(949-951)ATC>ATG	p.I317M	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.I267M	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	317					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					ATGGCCCCATCAGAAAGAAGC	0.443000													4	406					0	0	0.009096	0	0
MED16	10025	broad.mit.edu	37	19	875283	875283	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr19:875283C>T	uc002lqd.1	-	10	1883	c.1732G>A	c.(1732-1734)GAC>AAC	p.D578N	MED16_uc010drw.1_Missense_Mutation_p.D403N|MED16_uc002lqe.2_Missense_Mutation_p.D567N|MED16_uc002lqf.2_Missense_Mutation_p.D567N|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.D498N|MED16_uc010xfx.1_Missense_Mutation_p.D423N|MED16_uc010xfy.1_Missense_Mutation_p.D155N|MED16_uc010xfz.1_5'Flank	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	578					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCAGCCGGTCGCCGGGGCTC	0.562000													5	356					0	0	0.021553	0	0
OR7D4	125958	broad.mit.edu	37	19	9325451	9325451	+	Silent	SNP	A	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr19:9325451A>C	uc002mla.1	-	1	63	c.63T>G	c.(61-63)CCT>CCG	p.P21P		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCTGCAGTTCAGGATCATCTG	0.517000													39	334					0	0	0.033182	0	0
TTN	7273	broad.mit.edu	37	2	179669298	179669298	+	Silent	SNP	G	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr2:179669298G>T	uc002und.2	-	2	297	c.72C>A	c.(70-72)ACC>ACA	p.T24T	TTN_uc010zfg.1_Silent_p.T24T|TTN_uc010zfh.1_Silent_p.T24T|TTN_uc010zfi.1_Silent_p.T24T|TTN_uc010zfj.1_Silent_p.T24T|TTN_uc002unb.2_Silent_p.T24T			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	24							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGCCTCAAAGGTTGCGGTAC	0.458000													41	205					7.05121e-23	7.85916e-23	0.010771	1	0
DNAH7	56171	broad.mit.edu	37	2	196741377	196741377	+	Missense_Mutation	SNP	A	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr2:196741377A>T	uc002utj.3	-	37	6109	c.6008T>A	c.(6007-6009)CTA>CAA	p.L2003Q		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2003	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAAGTTAATTAGCAGAGGTTT	0.323000													34	258					0	0	0.012213	0	0
PLCB1	23236	broad.mit.edu	37	20	8698413	8698413	+	Silent	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr20:8698413C>T	uc002wnb.2	+	14	1434	c.1431C>T	c.(1429-1431)AGC>AGT	p.S477S	PLCB1_uc010zrb.1_Silent_p.S376S|PLCB1_uc002wna.2_Silent_p.S477S|PLCB1_uc002wnc.1_Silent_p.S376S|PLCB1_uc002wnd.1_Silent_p.S54S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	477					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CAGAAGGAAGCGGCAAAAAGA	0.473000													61	304					0	0	0.014410	0	0
BIRC7	79444	broad.mit.edu	37	20	61867534	61867534	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr20:61867534G>A	uc002yej.2	+	1	259	c.86G>A	c.(85-87)CGC>CAC	p.R29H	BIRC7_uc010gkc.1_Missense_Mutation_p.R29H|BIRC7_uc002yei.2_Missense_Mutation_p.R29H|hsa-mir-3196|MI0014241_5'Flank	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	29					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					ACGCAGGAGCGCTGTGGACCC	0.677000													7	28					0	0	0.029380	0	0
C21orf99	149992	broad.mit.edu	37	21	14414926	14414926	+	RNA	SNP	A	C	C	rs2821611		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr21:14414926A>C	uc002yiy.3	+	2		c.363A>C			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						AAACAGGACAACTCTGATGAA	0.403000													3	190					0	0	0.009096	0	0
TIAM1	7074	broad.mit.edu	37	21	32492855	32492855	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr21:32492855C>T	uc002yow.1	-	29	5079	c.4607G>A	c.(4606-4608)CGG>CAG	p.R1536Q	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.R1476Q	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1536					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GCCTCTTTCCCGCTGACTGAT	0.597000													54	269					0	0	0.014410	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45483547	45483547	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr21:45483547C>T	uc002zea.2	+	7	1088	c.919C>T	c.(919-921)CGC>TGC	p.R307C	TRAPPC10_uc010gpo.2_Missense_Mutation_p.R18C	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	307					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						GTTAGATCTGCGCAGTTACCT	0.587000													14	329					0	0	0.024245	0	0
SDF2L1	23753	broad.mit.edu	37	22	21998372	21998372	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr22:21998372C>T	uc002zvf.2	+	3	658	c.574C>T	c.(574-576)CCC>TCC	p.P192S		NM_022044	NP_071327	Q9HCN8	SDF2L_HUMAN	stromal cell-derived factor 2-like 1 precursor	192	MIR 3.					endoplasmic reticulum lumen|membrane					0	Colorectal(54;0.105)					CCACGGCATGCCCAGTGCCAA	0.582000											OREG0026342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	182					0	0	0.014758	0	0
MYO18B	84700	broad.mit.edu	37	22	26224877	26224877	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr22:26224877G>A	uc003abz.1	+	15	3171	c.2921G>A	c.(2920-2922)CGC>CAC	p.R974H	MYO18B_uc003aca.1_Missense_Mutation_p.R855H|MYO18B_uc010guy.1_Missense_Mutation_p.R855H|MYO18B_uc010guz.1_Missense_Mutation_p.R855H|MYO18B_uc011aka.1_Missense_Mutation_p.R128H|MYO18B_uc011akb.1_Missense_Mutation_p.R487H	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	974	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GCCCATGAGCGCCTGCAGCTG	0.617000													31	211					0	0	0.009535	0	0
MST1	4485	broad.mit.edu	37	3	49723304	49723304	+	Silent	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr3:49723304C>T	uc003cxg.2	-	10	1311	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	MST1_uc011bcs.1_Missense_Mutation_p.R452H	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	399	Kringle 4.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCGGCTTGTGCGGCGTCTCAG	0.682000													6	364					0	0	0.029380	0	0
SLC15A2	6565	broad.mit.edu	37	3	121659777	121659777	+	Missense_Mutation	SNP	C	T	T	rs138745887		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr3:121659777C>T	uc003eep.2	+	22	2266	c.2113C>T	c.(2113-2115)CGG>TGG	p.R705W	SLC15A2_uc011bjn.1_Missense_Mutation_p.R674W	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	705					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AGAGGATATGCGGGGTCCAGC	0.473000													5	407					0	0	0.014758	0	0
GPR160	26996	broad.mit.edu	37	3	169801801	169801801	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr3:169801801A>G	uc003fgi.2	+	4	631	c.41A>G	c.(40-42)CAG>CGG	p.Q14R	GPR160_uc010hwq.2_Missense_Mutation_p.Q14R	NM_014373	NP_055188	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	14	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTTCAGTACCAGTTACGTCAA	0.343000													7	370					0	0	0.006214	0	0
MUC4	4585	broad.mit.edu	37	3	195510108	195510108	+	Silent	SNP	G	A	A	rs142152945	by1000genomes	TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr3:195510108G>A	uc011bto.1	-	3	8419	c.7959C>T	c.(7957-7959)CAC>CAT	p.H2653H	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.592000													3	20					0	0	0.014758	0	0
POLN	353497	broad.mit.edu	37	4	2210033	2210033	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:2210033T>C	uc003ger.2	-	3	395	c.395A>G	c.(394-396)AAG>AGG	p.K132R	POLN_uc010ich.1_5'UTR|POLN_uc011bvi.1_Missense_Mutation_p.K132R	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	132					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TTTATGCCCCTTTTTCTGTAG	0.313000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					5	394					0	0	0.014758	0	0
SH3TC1	54436	broad.mit.edu	37	4	8218823	8218823	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:8218823G>A	uc003gkv.3	+	7	869	c.768G>A	c.(766-768)CCG>CCA	p.P256P	SH3TC1_uc003gkw.3_Silent_p.P180P|SH3TC1_uc003gkx.3_Intron	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	256							binding			large_intestine(2)|pancreas(1)	3						ACTCTTCACCGCCGAGCCCCA	0.667000													26	100					0	0	0.021523	0	0
DHX15	1665	broad.mit.edu	37	4	24557890	24557890	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:24557890T>G	uc003gqx.2	-	4	1013	c.845A>C	c.(844-846)CAG>CCG	p.Q282P		NM_001358	NP_001349	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 15	282	Helicase ATP-binding.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(1)	1		Breast(46;0.0503)				ATCTGATCTCTGTCTTACAAC	0.383000													32	249					0	0	0.013726	0	0
C4orf29	80167	broad.mit.edu	37	4	128904142	128904142	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:128904142G>A	uc003ifr.2	+	2	350	c.32G>A	c.(31-33)CGG>CAG	p.R11Q	C4orf29_uc003ifq.1_RNA|C4orf29_uc003ifs.2_5'UTR	NM_001039717	NP_001034806	Q0P651	CD029_HUMAN	hypothetical protein LOC80167 precursor	11						extracellular region				ovary(1)	1						ATTCTATACCGGAGACTTCTC	0.328000													5	28					0	0	0.014758	0	0
PCDH10	57575	broad.mit.edu	37	4	134084134	134084134	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:134084134A>G	uc003iha.2	+	4	3626	c.2800A>G	c.(2800-2802)ATG>GTG	p.M934V		NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	934	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCTTACAGGTATGGATCTCTT	0.468000													37	314					0	0	0.023175	0	0
F11	2160	broad.mit.edu	37	4	187194268	187194268	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:187194268A>G	uc003iza.1	+	4	595	c.262A>G	c.(262-264)AGA>GGA	p.R88G	F11_uc003iyz.2_Missense_Mutation_p.R88G	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	88	Apple 1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AACACTGCCAAGAGTGAATAG	0.338000													38	204					0	0	0.021022	0	0
FBXL7	23194	broad.mit.edu	37	5	15936815	15936815	+	Silent	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:15936815C>T	uc003jfn.1	+	4	1477	c.996C>T	c.(994-996)AGC>AGT	p.S332S		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	332	LRR 6.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TGAGCGTCAGCGACTGCCGCT	0.677000													9	54					0	0	0.004482	0	0
LOC100133050	100133050	broad.mit.edu	37	5	99715474	99715474	+	RNA	SNP	T	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:99715474T>G	uc011cuw.1	-	4		c.436A>C				NR_027503				Homo sapiens glucuronidase, beta pseudogene (LOC100133050), non-coding RNA.												0						GGGCAGAAGGTGTTGGCGCCA	0.577000													6	33					0	0	0.016522	0	0
FBN2	2201	broad.mit.edu	37	5	127685102	127685102	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:127685102C>A	uc003kuu.2	-	23	3365	c.2926G>T	c.(2926-2928)GGA>TGA	p.G976*	FBN2_uc003kuv.2_Nonsense_Mutation_p.G943*	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	976	EGF-like 14; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGAAAAGATCCCTTACTGTTG	0.468000													23	139					4.72057e-08	4.95197e-08	0.021523	1	0
TBCC	6903	broad.mit.edu	37	6	42713296	42713296	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:42713296C>A	uc003osl.2	-	1	589	c.516G>T	c.(514-516)AAG>AAT	p.K172N		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	172	C-CAP/cofactor C-like.				'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			CTTCCGCCTTCTTGGGCAGCG	0.617000													11	65					6.42651e-13	6.87637e-13	0.010729	1	0
TTBK1	84630	broad.mit.edu	37	6	43227327	43227327	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:43227327G>A	uc003ouq.1	+	12	1586	c.1307G>A	c.(1306-1308)CGT>CAT	p.R436H		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	436						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TCCCCAGTGCGTGCCCCCCCA	0.677000													13	72					0	0	0.020292	0	0
ZNF292	23036	broad.mit.edu	37	6	87965459	87965459	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:87965459G>A	uc003plm.3	+	8	2153	c.2112G>A	c.(2110-2112)GGG>GGA	p.G704G		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	704	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ATGTGAAGGGGCATAAAGATA	0.368000													5	232					0	0	0.021553	0	0
C6orf167	253714	broad.mit.edu	37	6	97616054	97616054	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:97616054G>A	uc003ppb.2	-	20	3168	c.2902C>T	c.(2902-2904)CGG>TGG	p.R968W	C6orf167_uc011eaf.1_Missense_Mutation_p.R928W	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	968					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TCTATGATCCGGAATAGTAAT	0.388000													6	341					0	0	0.029380	0	0
HSF2	3298	broad.mit.edu	37	6	122743891	122743891	+	Missense_Mutation	SNP	G	A	A	rs145103558	byFrequency	TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:122743891G>A	uc003pyu.2	+	9	1046	c.859G>A	c.(859-861)GTT>ATT	p.V287I	HSF2_uc003pyv.2_Missense_Mutation_p.V287I	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	287					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TATTGTCATCGTTGAAGATGA	0.393000													64	394					0	0	0.014410	0	0
LATS1	9113	broad.mit.edu	37	6	149982932	149982932	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr6:149982932T>A	uc003qmu.1	-	8	3874	c.3326A>T	c.(3325-3327)CAG>CTG	p.Q1109L	LATS1_uc010kif.1_Missense_Mutation_p.Q1004L	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	1109					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATCCGACTGCTGCTCTGAGCC	0.343000													6	520					0	0	0.021553	0	0
THAP5	168451	broad.mit.edu	37	7	108204686	108204686	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr7:108204686G>A	uc003vfm.2	-	3	1291	c.1137C>T	c.(1135-1137)AAC>AAT	p.N379N	THAP5_uc003vfl.2_Silent_p.N337N	NM_001130475	NP_001123947	Q7Z6K1	THAP5_HUMAN	THAP domain containing 5 isoform 1	379	Potential.				cell cycle|negative regulation of cell cycle	nucleus	DNA binding|metal ion binding|protease binding				0						TAATCTTGACGTTTTCTTCAG	0.338000													46	321					0	0	0.011902	0	0
ZNF777	27153	broad.mit.edu	37	7	149152353	149152353	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr7:149152353C>T	uc003wfv.2	-	2	924	c.761G>A	c.(760-762)CGG>CAG	p.R254Q		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	254	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GTTCTCCAGCCGCCTCTGCAG	0.582000													6	476					0	0	0.021553	0	0
FASTK	10922	broad.mit.edu	37	7	150775658	150775658	+	Silent	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr7:150775658G>A	uc003wix.1	-	4	914	c.816C>T	c.(814-816)CTC>CTT	p.L272L	uc011kvf.1_5'Flank|FASTK_uc003wiw.1_Silent_p.L33L|FASTK_uc003wiy.1_Silent_p.L131L|FASTK_uc003wiz.1_Silent_p.L245L|FASTK_uc003wja.1_Intron	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	272					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		CCTTGCTGCTGAGTTGCGTTT	0.627000													29	119					0	0	0.037714	0	0
DLGAP2	9228	broad.mit.edu	37	8	1649367	1649367	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr8:1649367T>A	uc003wpl.2	+	12	2820	c.2723T>A	c.(2722-2724)GTC>GAC	p.V908D	DLGAP2_uc003wpm.2_Missense_Mutation_p.V894D	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	987					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAAAGAAAGGTCCCGCCTCCA	0.612000													4	14					0	0	0.009096	0	0
RP1	6101	broad.mit.edu	37	8	55540482	55540482	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr8:55540482C>A	uc003xsd.1	+	4	4188	c.4040C>A	c.(4039-4041)TCC>TAC	p.S1347Y	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1347					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTTTTAAACTCCAAAGAAAAC	0.378000													34	251					3.76114e-14	4.10655e-14	0.019004	1	0
CDKN2A	1029	broad.mit.edu	37	9	21971111	21971111	+	Missense_Mutation	SNP	G	A	A	rs121913385		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:21971111G>A	uc003zpk.2	-	2	459	c.247C>T	c.(247-249)CAC>TAC	p.H83Y	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.A138V	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	83	ANK 3.		H -> N (in a lung tumor).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.H83Y(28)|p.?(13)|p.H83fs*2(2)|p.H83P(2)|p.H83N(1)|p.V82fs*62(1)|p.V82_E88del(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.A138V(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.H83R(1)|p.H83Q(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCAGCGTCGTGCACGGGTCGG	0.741000	H83Y(CALU3_LUNG)|H83Y(JHH2_LIVER)|H83Y(HS944T_SKIN)|H83Y(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|H83Y(OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			6	49					0	0	0.008291	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37349361	37349361	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:37349361C>G	uc003zzq.2	+	7	1168	c.995C>G	c.(994-996)CCT>CGT	p.P332R	ZCCHC7_uc011lqh.1_Missense_Mutation_p.P42R|ZCCHC7_uc011lqi.1_Missense_Mutation_p.P331R|ZCCHC7_uc010mlt.2_Missense_Mutation_p.P331R	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	332							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		CAGACCAAACCTGGACCACCC	0.413000													40	301					0	0	0.030466	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37349387	37349387	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:37349387C>T	uc003zzq.2	+	7	1194	c.1021C>T	c.(1021-1023)CCT>TCT	p.P341S	ZCCHC7_uc011lqh.1_Missense_Mutation_p.P51S|ZCCHC7_uc011lqi.1_Missense_Mutation_p.P340S|ZCCHC7_uc010mlt.2_Missense_Mutation_p.P340S	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	341							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		GCCGAAGACCCCTTCAAGACC	0.418000													37	300					0	0	0.027894	0	0
OR13C3	138803	broad.mit.edu	37	9	107298270	107298270	+	Silent	SNP	C	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:107298270C>A	uc004bcb.1	-	1	825	c.825G>T	c.(823-825)CTG>CTT	p.L275L		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	275	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCACCACAGTCAGGTGAGCTG	0.423000													6	524					0.00116845	0.00120215	0.021553	1	0
SH3KBP1	30011	broad.mit.edu	37	X	19568150	19568150	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chrX:19568150G>A	uc004czm.2	-	14	1752	c.1436C>T	c.(1435-1437)CCG>CTG	p.P479L	SH3KBP1_uc011mje.1_Missense_Mutation_p.P218L|SH3KBP1_uc011mjf.1_Missense_Mutation_p.P241L|SH3KBP1_uc004czl.2_Missense_Mutation_p.P442L|SH3KBP1_uc010nfm.2_5'UTR	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	479					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GCTTGTGGTCGGATGACTGAG	0.443000													90	270					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	X	51150365	51150365	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chrX:51150365G>A	uc004dpj.2	+	1	599	c.497G>A	c.(496-498)CGT>CAT	p.R166H		NM_203407	NP_981952			hypothetical protein LOC340602																		CCAGGGCGGCGTCTGTTTCCT	0.667000													5	10					0	0	0.029380	0	0
CXorf41	139212	broad.mit.edu	37	X	106456172	106456172	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chrX:106456172T>G	uc004enc.2	+	2	129	c.67T>G	c.(67-69)TTT>GTT	p.F23V	CXorf41_uc004end.2_Missense_Mutation_p.F23V	NM_173494	NP_775765	Q9NQM4	CX041_HUMAN	hypothetical protein LOC139212	23											0						AAATGTAGACTTTGAGAGTGT	0.348000													50	113					0	0	0.014410	0	0
STAG2	10735	broad.mit.edu	37	X	123224426	123224426	+	Silent	SNP	T	C	C			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chrX:123224426T>C	uc004etz.3	+	30	3618	c.3279T>C	c.(3277-3279)ACT>ACC	p.T1093T	STAG2_uc004eua.2_Silent_p.T1093T|STAG2_uc004eub.2_Silent_p.T1093T|STAG2_uc004euc.2_Silent_p.T1093T|STAG2_uc004eud.2_Silent_p.T1093T|STAG2_uc004eue.2_Silent_p.T1093T	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1093					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTTTTCCAGCTGAAGAAAGTA	0.348000													77	196					0	0	0.014410	0	0
GPC4	2239	broad.mit.edu	37	X	132439864	132439864	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chrX:132439864C>T	uc004exc.1	-	6	1303	c.1091G>A	c.(1090-1092)CGC>CAC	p.R364H	GPC4_uc011mvg.1_Missense_Mutation_p.R294H	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	364					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					TGGTCTGAAGCGAGCACTGAA	0.552000													159	417					0	0	0.014410	0	0
TMCO1	54499	broad.mit.edu	37	1	165712550	165712551	+	Splice_Site	INS	-	A	A			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr1:165712550_165712551insA	uc001gdj.3	-	6	473	c.324_splice	c.e6-1	p.I108_splice	TMCO1_uc001gdl.3_Splice_Site_p.I24_splice|TMCO1_uc001gdm.3_Splice_Site_p.I24_splice|TMCO1_uc001gdk.3_Splice_Site_p.I96_splice|TMCO1_uc001gdn.3_Splice_Site	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1							endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CCATCAAATCTAAAAGAAAAAA	0.381													14	399	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24822125	24822127	+	In_Frame_Del	DEL	GAA	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr10:24822125_24822127delGAA	uc001iru.3	+	16	3776_3778	c.3373_3375delGAA	c.(3373-3375)GAAdel	p.E1129del	KIAA1217_uc001irs.2_In_Frame_Del_p.E1049del|KIAA1217_uc001irt.3_In_Frame_Del_p.E1094del|KIAA1217_uc010qcy.1_In_Frame_Del_p.E1093del|KIAA1217_uc010qcz.1_In_Frame_Del_p.E1094del|KIAA1217_uc001irw.2_In_Frame_Del_p.E812del|KIAA1217_uc001irz.2_In_Frame_Del_p.E812del|KIAA1217_uc001irx.2_In_Frame_Del_p.E812del|KIAA1217_uc001iry.2_In_Frame_Del_p.E812del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1129					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGATGAGGAGGAAGAAGAAGAAG	0.552													7	216	---	---	---	---					
WASF3	10810	broad.mit.edu	37	13	27255387	27255387	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr13:27255387delC	uc001uqv.2	+	8	1138	c.913delC	c.(913-915)CCCfs	p.P305fs	WASF3_uc001uqw.2_Frame_Shift_Del_p.P302fs	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	305	Poly-Pro.				actin filament polymerization	cytoplasm|cytoskeleton	actin binding			pancreas(1)	1	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		TCAGCAGCCGCCCCCCCCGCC	0.682													7	296	---	---	---	---					
SUPT16H	11198	broad.mit.edu	37	14	21833041	21833041	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:21833041delT	uc001wao.2	-	10	1517	c.1178delA	c.(1177-1179)AAGfs	p.K393fs		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	393					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTCTTCTGGCTTTTTCCCCTC	0.418													7	445	---	---	---	---					
OR10G3	26533	broad.mit.edu	37	14	22038564	22038564	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr14:22038564delG	uc010tmb.1	-	1	312	c.312delC	c.(310-312)TTCfs	p.F104fs		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		GGAAGTGATAGAAATAGAGTT	0.502													19	214	---	---	---	---					
PICK1	9463	broad.mit.edu	37	22	38471034	38471036	+	In_Frame_Del	DEL	GGA	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr22:38471034_38471036delGGA	uc003auq.2	+	13	1533_1535	c.1143_1145delGGA	c.(1141-1146)GGGGAG>GGG	p.E388del	PICK1_uc003aur.2_In_Frame_Del_p.E388del|PICK1_uc003aus.2_In_Frame_Del_p.E388del|PICK1_uc003aut.2_In_Frame_Del_p.E388del	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	protein interacting with C kinase 1	388	Poly-Glu.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding				0	Melanoma(58;0.045)					TCACAGATGGggaggaggaggag	0.562													7	126	---	---	---	---					
HGFAC	3083	broad.mit.edu	37	4	3443798	3443800	+	In_Frame_Del	DEL	CTG	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:3443798_3443800delCTG	uc003ghc.2	+	1	73_75	c.70_72delCTG	c.(70-72)CTGdel	p.L29del	HGFAC_uc010icw.2_In_Frame_Del_p.L29del	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	29					proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTCCTCCTCCTGCTGCTGCTGC	0.714													9	163	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618484	89618486	+	In_Frame_Del	DEL	TCC	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr4:89618484_89618486delTCC	uc003hrx.2	-	1	538_540	c.420_422delGGA	c.(418-423)GAGGAA>GAA	p.140_141EE>E	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	140_141	Glu-rich.				nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		gtactcctcttcctcctcctcct	0.369													9	328	---	---	---	---					
CSNK1G3	1456	broad.mit.edu	37	5	122881495	122881495	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:122881495delA	uc003ktm.2	+	2	857	c.138delA	c.(136-138)GGAfs	p.G46fs	CSNK1G3_uc003ktl.2_Frame_Shift_Del_p.G46fs|CSNK1G3_uc003ktn.2_Frame_Shift_Del_p.G46fs|CSNK1G3_uc003kto.2_Frame_Shift_Del_p.G46fs|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Frame_Shift_Del_p.G46fs	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	46	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		TTAGAGTTGGAAAAAAAATTG	0.363													9	419	---	---	---	---					
PCDHA1	56147	broad.mit.edu	37	5	140165917	140165917	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:140165917delG	uc003lhb.2	+	1	42	c.42delG	c.(40-42)CTGfs	p.L14fs	PCDHA1_uc003lha.2_Frame_Shift_Del_p.L14fs|PCDHA1_uc003lgz.2_Frame_Shift_Del_p.L14fs	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	14					homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGGATCTGCTTCTTTGGC	0.557													96	628	---	---	---	---					
BTNL8	79908	broad.mit.edu	37	5	180375376	180375379	+	Splice_Site	DEL	GTAA	-	-	rs10541574		TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr5:180375376_180375379delGTAA	uc003mmp.2	+	5	1042	c.808_splice	c.e5+1	p.D270_splice	BTNL8_uc003mmq.2_Splice_Site_p.G313_splice|BTNL8_uc011dhg.1_Splice_Site_p.D145_splice|BTNL8_uc010jll.2_Intron|BTNL8_uc010jlm.2_Splice_Site_p.D154_splice|BTNL8_uc011dhh.1_Splice_Site_p.D86_splice	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor							integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGGAACTGGGTAAGTATGTGTCA	0.554													4	6	---	---	---	---					
EFHA2	286097	broad.mit.edu	37	8	16944491	16944491	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr8:16944491delA	uc003wxd.2	+	7	838	c.796delA	c.(796-798)AAAfs	p.K266fs		NM_181723	NP_859074	Q86XE3	EFHA2_HUMAN	EF-hand domain family, member A2	266	EF-hand 1.					integral to membrane	calcium ion binding			skin(1)	1				Colorectal(111;0.0686)|COAD - Colon adenocarcinoma(73;0.239)		GATATTCAGGAAAAAAAATGA	0.348													7	164	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr8:105440214delT	uc003yly.3	-	6	1215	c.1086delA	c.(1084-1086)AAAfs	p.K362fs		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													9	1003	---	---	---	---					
NOL8	55035	broad.mit.edu	37	9	95078137	95078138	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:95078137_95078138insT	uc004arv.2	-	7	1106_1107	c.769_770insA	c.(769-771)AGAfs	p.R257fs	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Frame_Shift_Ins_p.R189fs	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	257					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						ATCACAAGTTCTTTTTTGTGCA	0.436													43	259	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139390945	139390947	+	In_Frame_Del	DEL	GTG	-	-			TCGA-FQ-6552-01A-11D-1795-08	TCGA-FQ-6552-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	22c7f936-8646-4a24-9450-7a92900a07a0	97ac811a-f709-4e76-8fd9-adab59867ec1	g.chr9:139390945_139390947delGTG	uc004chz.2	-	34	7244_7246	c.7244_7246delCAC	c.(7243-7248)CCACAG>CAG	p.P2415del		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2415	Cytoplasmic (Potential).|Poly-Pro.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.Q2417*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTGCGGCTGTGGTGGTGGTGG	0.650			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	257	---	---	---	---					
