Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P2	11209	broad.mit.edu	37	1	16974243	16974243	+	RNA	SNP	G	C	C	rs142213352	by1000genomes	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:16974243G>C	uc009vow.2	+	5		c.1053G>C			MST1P2_uc010ocg.1_RNA|MST1P2_uc010och.1_Intron|MST1P2_uc010oci.1_RNA|MST1P2_uc001azk.2_Intron|MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_Intron|MST1P2_uc001azm.3_Intron					Homo sapiens cDNA FLJ53774 complete cds, moderately similar to Hepatocyte growth factor-like protein precursor.												0						GATCTCAGCTGTCGCTCGGGG	0.652000													3	61					0	0	0.004672	0	0
WDR78	79819	broad.mit.edu	37	1	67301403	67301403	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:67301403C>T	uc001dcx.2	-	11	1695	c.1639G>A	c.(1639-1641)GGA>AGA	p.G547R	WDR78_uc009waw.2_Missense_Mutation_p.G293R|WDR78_uc009wax.2_Intron	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	547	WD 1.									ovary(2)	2						TTAGGTGCTCCAATTGAAAAA	0.363000													100	363					0	0	0.014410	0	0
PTGFR	5737	broad.mit.edu	37	1	78958796	78958796	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:78958796T>A	uc001din.2	+	2	634	c.368T>A	c.(367-369)CTT>CAT	p.L123H	PTGFR_uc001dim.2_Missense_Mutation_p.L123H	NM_000959	NP_000950	P43088	PF2R_HUMAN	prostaglandin F receptor isoform a precursor	123	Helical; Name=3; (Potential).				parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			ovary(3)|breast(2)|skin(1)	6				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CTGTGCCCACTTCTTCTAGGC	0.383000													117	316					0	0	0.014410	0	0
LPHN2	23266	broad.mit.edu	37	1	82434946	82434946	+	Missense_Mutation	SNP	A	G	G	rs141036576		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:82434946A>G	uc001dit.3	+	14	2738	c.2557A>G	c.(2557-2559)ATC>GTC	p.I853V	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.I853V|LPHN2_uc001div.2_Missense_Mutation_p.I853V|LPHN2_uc009wcd.2_Missense_Mutation_p.I853V|LPHN2_uc001diw.2_Missense_Mutation_p.I437V|LPHN2_uc009wce.1_5'Flank	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	866	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GGCTATCTGCATCTTCACCTT	0.378000													154	615					0	0	0.014410	0	0
ADAR	103	broad.mit.edu	37	1	154569373	154569373	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:154569373G>A	uc001ffh.2	-	6	2378	c.2178C>T	c.(2176-2178)AAC>AAT	p.N726N	ADAR_uc001ffj.2_Silent_p.N707N|ADAR_uc001ffi.2_Silent_p.N726N|ADAR_uc001ffk.2_Silent_p.N431N	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	726	DRBM 3.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CACCCACAGGGTTGGTGTTCA	0.532000													84	330					0	0	0.014410	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174200396	174200396	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:174200396G>T	uc001gjx.2	+	4	640	c.445G>T	c.(445-447)GTA>TTA	p.V149L	RABGAP1L_uc009wwq.1_Missense_Mutation_p.V149L|RABGAP1L_uc001gjw.2_Missense_Mutation_p.V112L	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	149	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						ACGTAATGAAGTAGAGGCTTT	0.423000													132	550					3.47496e-60	3.99896e-60	0.014410	1	0
PRG4	10216	broad.mit.edu	37	1	186276229	186276229	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:186276229A>G	uc001gru.3	+	7	1429	c.1378A>G	c.(1378-1380)ACA>GCA	p.T460A	PRG4_uc001grt.3_Missense_Mutation_p.T419A|PRG4_uc009wyl.2_Missense_Mutation_p.T367A|PRG4_uc009wym.2_Missense_Mutation_p.T326A|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	460	15.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAGGAGCCTACACCCACCAC	0.657000													7	518					0	0	0.006214	0	0
USH2A	7399	broad.mit.edu	37	1	215813993	215813993	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:215813993C>T	uc001hku.1	-	68	15262	c.14875G>A	c.(14875-14877)GGC>AGC	p.G4959S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4959	Fibronectin type-III 35.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCAGTTGGCCGTTCAGGAGG	0.547000										HNSCC(13;0.011)			68	300					0	0	0.014410	0	0
HLX	3142	broad.mit.edu	37	1	221053417	221053417	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:221053417C>T	uc001hmv.3	+	1	675	c.218C>T	c.(217-219)ACC>ATC	p.T73I		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	73					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		GCCGCCCTCACCGCGCACTTG	0.716000													11	48					0	0	0.010729	0	0
JMJD4	65094	broad.mit.edu	37	1	227921617	227921617	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:227921617G>A	uc001hrb.2	-	3	683	c.683C>T	c.(682-684)GCG>GTG	p.A228V	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Missense_Mutation_p.A228V	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	228	JmjC.										0		Prostate(94;0.0885)				CCAGCTGCCCGCAGGCCCCGC	0.632000													4	175					0	0	0.009096	0	0
NID1	4811	broad.mit.edu	37	1	236193005	236193005	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:236193005G>A	uc001hxo.2	-	7	1685	c.1583C>T	c.(1582-1584)CCG>CTG	p.P528L	NID1_uc009xgd.2_Missense_Mutation_p.P528L	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	528	Nidogen G2 beta-barrel.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGATTGCCCGGGTGCCCCAC	0.612000													38	148					0	0	0.009718	0	0
RYR2	6262	broad.mit.edu	37	1	237754262	237754262	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:237754262C>T	uc001hyl.1	+	31	4250	c.4130C>T	c.(4129-4131)GCC>GTC	p.A1377V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1377	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAGATTATGCCCAGGAAAAG	0.413000													5	251					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	1	243251439	243251439	+	RNA	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:243251439T>A	uc001hzq.1	-	8		c.1193A>T								Homo sapiens cDNA FLJ52610 complete cds.																		aaaaaaaaaaTTCCTTTGGGA	0.214000													4	20					0	0	0.001168	0	0
CEP170	9859	broad.mit.edu	37	1	243333027	243333027	+	Silent	SNP	A	G	G	rs147752333	by1000genomes	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:243333027A>G	uc001hzs.2	-	12	2154	c.1746T>C	c.(1744-1746)CGT>CGC	p.R582R	CEP170_uc001hzt.2_Silent_p.R484R|CEP170_uc001hzu.2_Silent_p.R484R	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	582						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GTGAAACCCAACGTTTGCTTC	0.398000													4	284					0	0	0.009096	0	0
PPPDE1	51029	broad.mit.edu	37	1	244852624	244852624	+	Silent	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:244852624A>G	uc001iao.2	+	3	453	c.189A>G	c.(187-189)CTA>CTG	p.L63L	PPPDE1_uc001iap.2_Intron	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	63	PPPDE peptidase.									breast(3)	3						CTTCTGAACTAGGAGAAACAT	0.333000													15	592					0	0	0.003163	0	0
OR2B11	127623	broad.mit.edu	37	1	247614785	247614785	+	Missense_Mutation	SNP	G	A	A	rs149375684	byFrequency	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:247614785G>A	uc010pyx.1	-	1	500	c.500C>T	c.(499-501)ACG>ATG	p.T167M		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CAATTGCACCGTCAGGACCAC	0.592000													41	141					0	0	0.008740	0	0
OIT3	170392	broad.mit.edu	37	10	74658586	74658586	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr10:74658586C>A	uc001jte.1	+	2	444	c.226C>A	c.(226-228)CCA>ACA	p.P76T	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	76						nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					CTTCTGCATACCAGAAAACCA	0.567000													4	216					1.024e-07	1.09176e-07	0.000602	1	0
FANK1	92565	broad.mit.edu	37	10	127585212	127585212	+	Missense_Mutation	SNP	A	T	T	rs145156460	by1000genomes	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr10:127585212A>T	uc001ljh.3	+	1	105	c.1A>T	c.(1-3)ATG>TTG	p.M1L	DHX32_uc001ljg.1_5'Flank|FANK1_uc010quk.1_5'UTR|FANK1_uc009yan.2_Missense_Mutation_p.M1L	NM_145235	NP_660278	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains	1						cytoplasm|nucleus				ovary(1)	1		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GCAGCCGACCATGGAGCCCCA	0.562000													3	52					0	0	0.000602	0	0
Unknown	0	broad.mit.edu	37	10	134650331	134650331	+	Missense_Mutation	SNP	A	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr10:134650331A>T	uc010qux.1	-	37	5704	c.5704T>A	c.(5704-5706)TCA>ACA	p.S1902T		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.																		CTGTCCCCTGAGAGGTGCAGA	0.582000													106	325					0	0	0.014410	0	0
SYT8	90019	broad.mit.edu	37	11	1857148	1857148	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:1857148C>G	uc001lue.1	+	4	461	c.333C>G	c.(331-333)AGC>AGG	p.S111R	SYT8_uc010qxb.1_Missense_Mutation_p.S97R|SYT8_uc001lud.2_Missense_Mutation_p.S111R|SYT8_uc001luf.1_Missense_Mutation_p.S97R	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	111	Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGAGTCCAGCCCGGGGGATG	0.642000													40	181					0	0	0.014410	0	0
LOC650368	650368	broad.mit.edu	37	11	3427885	3427885	+	RNA	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:3427885A>G	uc010qxs.1	+	9		c.878A>G			LOC650368_uc001lxx.2_RNA|LOC650368_uc001lxy.2_RNA	NR_024248				Homo sapiens cDNA FLJ41654 fis, clone FEBRA2025463, weakly  similar to Homo sapiens HMT-1 mRNA for beta-1,4 mannosyltransferase.												0						AGCTTCACAGATCCACCGCTG	0.587000													4	118					0	0	0.009096	0	0
OR51A7	119687	broad.mit.edu	37	11	4928689	4928689	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:4928689C>T	uc010qyq.1	+	1	90	c.90C>T	c.(88-90)CCC>CCT	p.P30P		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCCATCCCCATTTGCCTCA	0.458000													26	337					0	0	0.005443	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703494	60703494	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:60703494T>G	uc001nqj.2	+	11	2380	c.2187T>G	c.(2185-2187)AGT>AGG	p.S729R	TMEM132A_uc001nqi.2_Missense_Mutation_p.S730R|TMEM132A_uc001nqm.2_5'UTR	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	729	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						TGGTGGTGAGTGGGGCAGGCG	0.731000													12	61					0	0	0.001855	0	0
CTTN	2017	broad.mit.edu	37	11	70279211	70279211	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:70279211C>T	uc001opv.3	+	16	1477	c.1271C>T	c.(1270-1272)GCG>GTG	p.A424V	CTTN_uc001opu.2_Missense_Mutation_p.A387V|CTTN_uc001opw.3_Missense_Mutation_p.A387V|CTTN_uc010rqm.1_Missense_Mutation_p.A108V|CTTN_uc001opx.2_Missense_Mutation_p.A108V	NM_005231	NP_005222	Q14247	SRC8_HUMAN	cortactin isoform a	424						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		CCCCAGGATGCGGCTTCCTTC	0.637000													6	276					0	0	0.001984	0	0
CHORDC1	26973	broad.mit.edu	37	11	89936496	89936496	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:89936496C>G	uc001pdg.2	-	9	1179	c.769G>C	c.(769-771)GTA>CTA	p.V257L	CHORDC1_uc009yvz.2_Missense_Mutation_p.V238L	NM_012124	NP_036256	Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain-containing	257	Interaction with HSP90AA1 and HSP90AB1 (By similarity).|CS.				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding				0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				TTTGCTTCTACTCGGCTAAGT	0.338000													78	413					0	0	0.014410	0	0
GYS2	2998	broad.mit.edu	37	12	21695431	21695431	+	Silent	SNP	G	A	A	rs146660038		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr12:21695431G>A	uc001rfb.2	-	13	1899	c.1644C>T	c.(1642-1644)TAC>TAT	p.Y548Y		NM_021957	NP_068776	P54840	GYS2_HUMAN	glycogen synthase 2	548					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			lung(1)|skin(1)	2						AACCCTCACCGTAAGCAGTAG	0.498000													5	229					0	0	0.000602	0	0
KRAS	3845	broad.mit.edu	37	12	25380275	25380275	+	Missense_Mutation	SNP	T	G	G	rs17851045		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr12:25380275T>G	uc001rgp.1	-	3	364	c.183A>C	c.(181-183)CAA>CAC	p.Q61H	KRAS_uc001rgq.1_Missense_Mutation_p.Q61H	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	61	GTP.		Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61H(140)|p.Q61L(51)|p.Q61R(44)|p.Q61K(24)|p.Q61P(11)|p.Q61E(10)|p.Q61D(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TGTACTCCTCTTGACCTGCTG	0.423000	Q61H(T3M4_PANCREAS)|Q61H(HS766T_PANCREAS)|Q61H(NCIH460_LUNG)|Q61H(NCIH1155_LUNG)|Q61H(CL11_LARGE_INTESTINE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			90	235					0	0	0.014410	0	0
KIF21A	55605	broad.mit.edu	37	12	39734798	39734798	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr12:39734798G>A	uc001rly.2	-	15	2166	c.2020C>T	c.(2020-2022)CTG>TTG	p.L674L	KIF21A_uc001rlw.2_5'UTR|KIF21A_uc001rlx.2_Silent_p.L661L|KIF21A_uc001rlz.2_Silent_p.L661L|KIF21A_uc010skl.1_Silent_p.L661L	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	674					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGCTTTTTCAGAGTCTGCAGT	0.373000													48	142					0	0	0.011902	0	0
LRRK2	120892	broad.mit.edu	37	12	40749924	40749924	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr12:40749924A>G	uc001rmg.3	+	46	6899	c.6778A>G	c.(6778-6780)AAA>GAA	p.K2260E	LRRK2_uc009zjw.2_Missense_Mutation_p.K1098E|LRRK2_uc001rmi.2_Missense_Mutation_p.K1093E	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2260					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TAGCAAACAAAAAAATTTTCT	0.214000													26	116					0	0	0.004656	0	0
BRCA2	675	broad.mit.edu	37	13	32914472	32914472	+	Missense_Mutation	SNP	C	G	G	rs80358831		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr13:32914472C>G	uc001uub.1	+	11	6207	c.5980C>G	c.(5980-5982)CAA>GAA	p.Q1994E		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1994	BRCA2 7.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TGCTTCATTACAAAACGCAAG	0.373000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			77	281					0	0	0.014410	0	0
LRP10	26020	broad.mit.edu	37	14	23344601	23344601	+	Silent	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr14:23344601G>C	uc001whd.2	+	5	997	c.444G>C	c.(442-444)CTG>CTC	p.L148L	LRP10_uc001whe.2_Silent_p.L24L	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	148	LDL-receptor class A 1.|Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TTCAGTGCCTGAACCACCGCT	0.592000													86	346					0	0	0.014410	0	0
GZMB	3002	broad.mit.edu	37	14	25103365	25103365	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr14:25103365A>G	uc001wps.2	-	1	68	c.2T>C	c.(1-3)ATG>ACG	p.M1T	GZMB_uc010ama.2_5'UTR|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	1					activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		GATTGGTTGCATCTTCTCAGG	0.587000													12	66					0	0	0.013537	0	0
TMEM63C	57156	broad.mit.edu	37	14	77715735	77715735	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr14:77715735T>C	uc001xtf.2	+	21	2184	c.1972T>C	c.(1972-1974)TCC>CCC	p.S658P	TMEM63C_uc010asq.1_Missense_Mutation_p.S658P	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	658	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GGCTGCCGTCTCCCAGGCCAT	0.552000													6	375					0	0	0.001984	0	0
EML5	161436	broad.mit.edu	37	14	89163192	89163192	+	Silent	SNP	T	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr14:89163192T>C	uc001xxg.2	-	16	2529	c.2343A>G	c.(2341-2343)TCA>TCG	p.S781S	EML5_uc001xxh.1_5'UTR	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	781	WD 12.					cytoplasm|microtubule				ovary(3)	3						CAGCCTTACCTGAGAAATCAA	0.398000													54	179					0	0	0.014410	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414132	22414132	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:22414132G>A	uc001yuf.2	+	1	431	c.431G>A	c.(430-432)CGC>CAC	p.R144H		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						ATTCTTTGTCGCATACGAGCG	0.463000													6	445					0	0	0.001168	0	0
OCA2	4948	broad.mit.edu	37	15	28171328	28171328	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:28171328T>C	uc001zbh.3	-	19	2134	c.2024A>G	c.(2023-2025)CAC>CGC	p.H675R	OCA2_uc010ayv.2_Missense_Mutation_p.H651R	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	675	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TTCCACTCTGTGTAGAATTAT	0.363000									Oculocutaneous_Albinism				105	302					0	0	0.014410	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102075	41102075	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:41102075C>G	uc001zmt.1	+	4	992	c.478C>G	c.(478-480)CAA>GAA	p.Q160E	DNAJC17_uc001zms.1_5'Flank|DNAJC17_uc010bbz.1_5'Flank|DNAJC17_uc010bca.1_5'Flank|DNAJC17_uc010bcb.1_5'Flank|ZFYVE19_uc001zmu.1_Missense_Mutation_p.Q160E|ZFYVE19_uc001zmv.1_5'UTR|ZFYVE19_uc001zmw.1_5'UTR|ZFYVE19_uc001zmx.1_5'UTR|ZFYVE19_uc010bcc.1_5'UTR	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	160							zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGAAGCCAAGCAAAAGCCCAG	0.567000													44	286					0	0	0.011902	0	0
VPS18	57617	broad.mit.edu	37	15	41195009	41195009	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:41195009A>G	uc001zne.2	+	5	2731	c.2392A>G	c.(2392-2394)ATC>GTC	p.I798V		NM_020857	NP_065908	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18	798					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			ovary(2)|large_intestine(1)	3		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TTTCGTCACCATCGACCACTT	0.557000													38	140					0	0	0.004289	0	0
ARID3B	10620	broad.mit.edu	37	15	74882198	74882198	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:74882198G>C	uc002aye.2	+	5	936	c.735G>C	c.(733-735)CAG>CAC	p.Q245H	ARID3B_uc002ayd.2_Missense_Mutation_p.Q245H|ARID3B_uc010bjs.1_5'Flank	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	245	ARID.|Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						TGGCCAAACAGATCCTGGACC	0.517000													79	267					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	15	85788521	85788521	+	RNA	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr15:85788521G>A	uc010upk.1	+	1		c.61G>A								Homo sapiens cDNA FLJ61448 complete cds, highly similar to Homo sapiens golgi autoantigen, golgin subfamily a-like, mRNA.																		GAGAGGCTGCGGGAGCTGGAG	0.672000													6	31					0	0	0.004007	0	0
TRAF7	84231	broad.mit.edu	37	16	2222247	2222247	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:2222247G>A	uc002cow.2	+	8	630	c.531G>A	c.(529-531)GTG>GTA	p.V177V		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	177					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						ACATCGCGGTGGCCGAGCAGA	0.667000													29	111					0	0	0.012213	0	0
BTBD12	84464	broad.mit.edu	37	16	3651029	3651029	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:3651029G>A	uc002cvp.2	-	5	1741	c.1114C>T	c.(1114-1116)CGG>TGG	p.R372W	BTBD12_uc002cvq.1_3'UTR	NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	372	Interaction with C20orf94, ERCC4 and MSH2.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GTCTGCAGCCGCACAGCCTGA	0.527000								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				4	229					0	0	0.009096	0	0
MYST1	84148	broad.mit.edu	37	16	31141454	31141454	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:31141454C>T	uc002eay.2	+	7	906	c.888C>T	c.(886-888)GCC>GCT	p.A296A	MYST1_uc002eax.2_Silent_p.A296A|MYST1_uc002eaz.2_Silent_p.A138A|MYST1_uc002eba.2_Silent_p.A80A|MYST1_uc002ebb.2_RNA	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	296					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						GGCAGGGGGCCCACATTGTTG	0.587000													167	599					0	0	0.014410	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:32890622T>G	uc002edh.1	-	5	440	c.264A>C	c.(262-264)AAA>AAC	p.K88N	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						CGTTGGTGTTTTTGTAGACCA	0.512000													5	84					0	0	0.001168	0	0
NUP93	9688	broad.mit.edu	37	16	56855453	56855453	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:56855453T>A	uc002eka.2	+	7	723	c.602T>A	c.(601-603)CTG>CAG	p.L201Q	NUP93_uc002ekb.2_Missense_Mutation_p.L78Q|NUP93_uc010vhi.1_Missense_Mutation_p.L78Q	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	201					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AATGGACACCTGCAGCCTAAC	0.403000													9	542					0	0	0.008291	0	0
MTSS1L	92154	broad.mit.edu	37	16	70697850	70697850	+	Silent	SNP	T	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:70697850T>C	uc002ezj.2	-	15	2234	c.1974A>G	c.(1972-1974)GCA>GCG	p.A658A		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	658					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						CCTCGGCCCCTGCCCCGGGGT	0.731000													4	18					0	0	0.009096	0	0
HYDIN	54768	broad.mit.edu	37	16	70977827	70977827	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:70977827C>A	uc002ezr.2	-	42	6682	c.6554G>T	c.(6553-6555)GGG>GTG	p.G2185V		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2186										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GTGGATGGGCCCCGGGGGGAG	0.383000													18	49					3.32936e-07	3.52377e-07	0.006122	1	0
DNAH9	1770	broad.mit.edu	37	17	11513860	11513860	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr17:11513860C>G	uc002gne.2	+	3	830	c.762C>G	c.(760-762)TTC>TTG	p.F254L	DNAH9_uc002gnd.1_Missense_Mutation_p.F254L	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	254	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGTTGGAGTTCTGGAAGAGCA	0.502000													45	118					0	0	0.011902	0	0
Unknown	0	broad.mit.edu	37	17	34233598	34233598	+	RNA	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr17:34233598G>C	uc010ctx.1	-	1		c.3356C>G								Homo sapiens cDNA FLJ43944 fis, clone TESTI4014392.																		GCCTCCTACTGTATTGGAGAG	0.522000													49	171					0	0	0.014410	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342197	60342197	+	RNA	SNP	T	C	C	rs76635225		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr17:60342197T>C	uc010woz.1	-	14		c.1932A>G				NR_027486				Homo sapiens cDNA FLJ60189 complete cds, highly similar to TBC1 domain family member 3.												0						TGGGAGGGGCTGGGCATGGTT	0.488000													5	167					0	0	0.003080	0	0
SCN4A	6329	broad.mit.edu	37	17	62029022	62029022	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr17:62029022T>C	uc002jds.1	-	14	2692	c.2615A>G	c.(2614-2616)GAG>GGG	p.E872G		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	872					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GGGGGCAGTCTCCCCCGCCTC	0.657000													5	50					0	0	0.006230	0	0
CARD14	79092	broad.mit.edu	37	17	78157817	78157817	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr17:78157817G>A	uc002jxw.1	+	4	650	c.455G>A	c.(454-456)CGG>CAG	p.R152Q	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.R152Q|CARD14_uc010wud.1_RNA	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	152	Potential.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTGCTGCGGCGGTGCCAGCAG	0.667000													16	44					0	0	0.004007	0	0
MYL12A	10627	broad.mit.edu	37	18	3253997	3253997	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr18:3253997C>T	uc002klr.2	+	3	687	c.292C>T	c.(292-294)CCT>TCT	p.P98S	MYL12A_uc002kls.2_Missense_Mutation_p.P104S	NM_006471	NP_006462	P19105	ML12A_HUMAN	myosin, light chain 12A, regulatory,	98	EF-hand 2.					myosin complex	calcium ion binding|protein binding				0						TGGCACAGATCCTGAAGATGT	0.383000													61	235					0	0	0.014410	0	0
PTPRS	5802	broad.mit.edu	37	19	5223252	5223252	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:5223252G>A	uc002mbv.2	-	18	2785	c.2551C>T	c.(2551-2553)CGC>TGC	p.R851C	PTPRS_uc002mbu.1_Intron|PTPRS_uc010xin.1_Intron|PTPRS_uc002mbw.2_Missense_Mutation_p.R829C|PTPRS_uc002mbx.2_Intron|PTPRS_uc002mby.2_Intron	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	851	Extracellular (Potential).|Fibronectin type-III 6.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGCTCCCAGCGTGCCAGCAGG	0.731000													8	20					0	0	0.004482	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7528746	7528746	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:7528746C>T	uc002mgi.2	+	12	2367	c.2114C>T	c.(2113-2115)GCC>GTC	p.A705V	ARHGEF18_uc010xjm.1_Missense_Mutation_p.A547V|ARHGEF18_uc002mgh.2_Missense_Mutation_p.A547V|ARHGEF18_uc002mgj.1_Missense_Mutation_p.A348V	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	705					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CTGGGCAGCGCCAACGGCCAG	0.662000													6	43					0	0	0.001168	0	0
FBN3	84467	broad.mit.edu	37	19	8173100	8173100	+	Silent	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:8173100C>A	uc002mjf.2	-	36	4662	c.4641G>T	c.(4639-4641)CCG>CCT	p.P1547P		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1547						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCTCACCACCCGGGCACAGGG	0.542000													105	298					1.15365e-47	1.31716e-47	0.014410	1	0
HAPLN4	404037	broad.mit.edu	37	19	19369455	19369455	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:19369455C>A	uc002nmb.2	-	4	749	c.694G>T	c.(694-696)GGC>TGC	p.G232C	HAPLN4_uc002nmc.2_Missense_Mutation_p.G232C	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	232	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			CCCCCCAGGCCGCCGCAGGGC	0.726000													32	76					1.06801e-11	1.16437e-11	0.009535	1	0
TBCB	1155	broad.mit.edu	37	19	36606509	36606509	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:36606509G>C	uc002odg.1	+	1	622	c.47G>C	c.(46-48)AGC>ACC	p.S16T	POLR2I_uc002ode.2_5'Flank|POLR2I_uc002odf.2_5'Flank|TBCB_uc002odh.1_5'Flank	NM_001281	NP_001272	Q99426	TBCB_HUMAN	cytoskeleton associated protein 1	16					'de novo' posttranslational protein folding|cell differentiation|nervous system development	cytoplasm|microtubule	protein binding				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTTTTCATCAGCAGCTCCCTC	0.682000													10	34					0	0	0.001855	0	0
ZNF229	7772	broad.mit.edu	37	19	44933836	44933836	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr19:44933836T>A	uc002oze.1	-	6	1554	c.1120A>T	c.(1120-1122)AGG>TGG	p.R374W	ZNF229_uc010ejk.1_Missense_Mutation_p.R28W|ZNF229_uc010ejl.1_Missense_Mutation_p.R368W	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				TAGGGTCTCCTTCCTGTGTGC	0.478000													56	546					0	0	0.014410	0	0
SLC4A5	57835	broad.mit.edu	37	2	74512976	74512976	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr2:74512976G>C	uc002sko.1	-	3	327	c.325C>G	c.(325-327)CCC>GCC	p.P109A	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.P109A|SLC4A5_uc010ffc.1_Missense_Mutation_p.P109A|SLC4A5_uc002skp.1_Missense_Mutation_p.P45A|SLC4A5_uc002sks.1_Missense_Mutation_p.P109A	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	109	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						GTGGGGTTGGGAGCCTCATCT	0.617000													22	62					0	0	0.010504	0	0
NEB	4703	broad.mit.edu	37	2	152477444	152477444	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr2:152477444T>A	uc010fnx.2	-	68	10011	c.9820A>T	c.(9820-9822)ATT>TTT	p.I3274F		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3274	Nebulin 89.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCACTGGCAATATCCCGAGAG	0.383000													26	60					0	0	0.008361	0	0
BARD1	580	broad.mit.edu	37	2	215657051	215657051	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr2:215657051G>A	uc002veu.2	-	3	469	c.334C>T	c.(334-336)CGA>TGA	p.R112*	BARD1_uc010zjm.1_Intron	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	112	Interaction with BRCA1.				cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGCAAATTTCGAAGCTTACTA	0.373000									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				56	169					0	0	0.014410	0	0
ACSL3	2181	broad.mit.edu	37	2	223797991	223797992	+	Nonsense_Mutation	DNP	GC	TG	TG			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr2:223797991_223797992GC>TG	uc002vni.2	+	15	2291_2292	c.1840_1841GC>TG	c.(1840-1842)GCA>TGA	p.A614*	ACSL3_uc002vnj.2_Nonsense_Mutation_p.A614*	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	614	Cytoplasmic (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	TTGTGCATATGCAAACAGGTAA	0.366000			T	ETV1	prostate								35	142					0	0	0.004672	0	0
SFRS6	6431	broad.mit.edu	37	20	42088476	42088476	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr20:42088476A>G	uc010zwg.1	+	3	492	c.322A>G	c.(322-324)ACA>GCA	p.T108A	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.T108A	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	108					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACCTGTTCGTACAGAATACAG	0.403000													15	497					0	0	0.002450	0	0
C20orf106	200232	broad.mit.edu	37	20	55099898	55099898	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr20:55099898C>T	uc002xxx.2	+	1	114	c.34C>T	c.(34-36)CTG>TTG	p.L12L	GCNT7_uc010zzg.1_Intron|C20orf107_uc010zzh.1_Silent_p.L12L	NM_001012971	NP_001012989	Q5JX71	CT106_HUMAN	hypothetical protein LOC200232 precursor	12						integral to membrane					0			Colorectal(105;0.202)			GGTCCTGCTTCTGTGCCTCAC	0.547000													209	357					0	0	0.014410	0	0
NRIP1	8204	broad.mit.edu	37	21	16338727	16338727	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr21:16338727G>A	uc002yjx.2	-	4	2385	c.1787C>T	c.(1786-1788)TCT>TTT	p.S596F		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	596	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TGAGTGGTTAGATGCAGTATT	0.453000													93	759					0	0	0.014410	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19713840	19713840	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr21:19713840T>G	uc002ykw.2	-	13	1485	c.1454A>C	c.(1453-1455)AAG>ACG	p.K485T		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	485	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						ACTCAGGATCTTGTTTTTAAA	0.403000													89	270					0	0	0.014410	0	0
CBS	875	broad.mit.edu	37	21	44478982	44478982	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr21:44478982C>G	uc002zcu.2	-	14	1565	c.1320G>C	c.(1318-1320)GAG>GAC	p.E440D	CBS_uc002zcs.1_Missense_Mutation_p.E335D|CBS_uc002zct.2_Missense_Mutation_p.E440D|CBS_uc002zcw.3_Missense_Mutation_p.E440D|CBS_uc002zcv.2_Missense_Mutation_p.E440D|CBS_uc002zcx.2_Missense_Mutation_p.E59D	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	440	CBS.				cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	CGAAGCCCTTCTCCCGGAGGA	0.667000													4	20					0	0	0.009096	0	0
SBF1	6305	broad.mit.edu	37	22	50906347	50906347	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr22:50906347G>A	uc003blh.2	-	3	342	c.147C>T	c.(145-147)TGC>TGT	p.C49C	SBF1_uc011arx.1_5'Flank|SBF1_uc003bli.2_Silent_p.C49C	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	49	UDENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGCTGGGCTGGCAAAACTGCA	0.637000													5	179					0	0	0.001168	0	0
TTLL3	26140	broad.mit.edu	37	3	9868729	9868729	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:9868729G>A	uc003btg.2	+	9	1139	c.923G>A	c.(922-924)GGC>GAC	p.G308D	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.G275D|TTLL3_uc003btf.3_Missense_Mutation_p.G96D|TTLL3_uc010hco.1_Missense_Mutation_p.G244D|TTLL3_uc003bth.3_Missense_Mutation_p.G96D|TTLL3_uc011atj.1_Missense_Mutation_p.G244D|TTLL3_uc003btj.3_Missense_Mutation_p.G96D|TTLL3_uc003bti.3_Missense_Mutation_p.G96D|TTLL3_uc003btk.2_Missense_Mutation_p.G111D	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	308	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					CTGGTGAACGGCAACCCCGTG	0.582000													5	435					0	0	0.001168	0	0
CHST2	9435	broad.mit.edu	37	3	142841171	142841171	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:142841171G>A	uc003evm.2	+	2	2402	c.1513G>A	c.(1513-1515)GTC>ATC	p.V505I		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	505	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GCCCATGGCCGTCCTGGGCTA	0.607000													33	175					0	0	0.013726	0	0
PLOD2	5352	broad.mit.edu	37	3	145799644	145799644	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:145799644G>A	uc003evs.1	-	12	1745	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I	PLOD2_uc003evq.1_Silent_p.I73I|PLOD2_uc011bnm.1_Silent_p.I358I|PLOD2_uc003evr.1_Silent_p.I413I	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	413					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	GAGGAGCAATGATCTTTCTAA	0.368000													50	222					0	0	0.014410	0	0
ARPM1	84517	broad.mit.edu	37	3	169485632	169485632	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:169485632A>G	uc003ffs.1	-	2	1082	c.707T>C	c.(706-708)GTT>GCT	p.V236A	TERC_uc003ffr.1_5'Flank	NM_032487	NP_115876	Q9BYD9	ARPM1_HUMAN	actin related protein M1	236						cytoplasm|cytoskeleton					0	all_cancers(22;9.55e-22)|all_epithelial(15;2.04e-26)|all_lung(20;5.05e-16)|Lung NSC(18;2.19e-15)|Ovarian(172;0.000223)|Breast(254;0.197)		Epithelial(2;4.03e-64)|all cancers(2;5.01e-59)|Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			TAGTTGGTAAACTTTCTCTAG	0.463000													15	590					0	0	0.004007	0	0
MUC4	4585	broad.mit.edu	37	3	195508343	195508343	+	Missense_Mutation	SNP	A	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:195508343A>T	uc011bto.1	-	3	10184	c.9724T>A	c.(9724-9726)TCC>ACC	p.S3242T	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_5'Flank|MUC4_uc011btg.1_5'Flank|MUC4_uc011bth.1_5'Flank|MUC4_uc011bti.1_5'Flank|MUC4_uc011btj.1_5'Flank|MUC4_uc011btk.1_5'Flank|MUC4_uc011btl.1_5'Flank|MUC4_uc011btm.1_5'Flank|MUC4_uc011btn.1_5'Flank|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TCACCTGTGGAAGCTGAGGAA	0.587000													5	20					0	0	0.001984	0	0
MUC4	4585	broad.mit.edu	37	3	195508380	195508380	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:195508380G>A	uc011bto.1	-	3	10147	c.9687C>T	c.(9685-9687)CAC>CAT	p.H3229H	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_5'Flank|MUC4_uc011btg.1_5'Flank|MUC4_uc011bth.1_5'Flank|MUC4_uc011bti.1_5'Flank|MUC4_uc011btj.1_5'Flank|MUC4_uc011btk.1_5'Flank|MUC4_uc011btl.1_5'Flank|MUC4_uc011btm.1_5'Flank|MUC4_uc011btn.1_5'Flank|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.602000													4	19					0	0	0.001168	0	0
MUC4	4585	broad.mit.edu	37	3	195511815	195511815	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr3:195511815G>A	uc011bto.1	-	2	7096	c.6636C>T	c.(6634-6636)ACC>ACT	p.T2212T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGGGCTGGTGACAGGAA	0.602000													3	21					0	0	0.009096	0	0
LRBA	987	broad.mit.edu	37	4	151837875	151837875	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr4:151837875G>A	uc010ipj.2	-	6	1135	c.661C>T	c.(661-663)CCT>TCT	p.P221S	LRBA_uc003ilu.3_Missense_Mutation_p.P221S|LRBA_uc010ipk.1_Missense_Mutation_p.P140S	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	221						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TTGGCTATAGGAGGTAATGCA	0.323000													6	174					0	0	0.003080	0	0
FHDC1	85462	broad.mit.edu	37	4	153895991	153895991	+	Silent	SNP	C	G	G	rs150094379		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr4:153895991C>G	uc003inf.2	+	11	1623	c.1548C>G	c.(1546-1548)CTC>CTG	p.L516L		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	516					actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					AGGGCCTGCTCCCTTTCCTGC	0.687000													16	65					0	0	0.003163	0	0
TRIML1	339976	broad.mit.edu	37	4	189068520	189068520	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr4:189068520C>T	uc003izm.1	+	6	1516	c.1401C>T	c.(1399-1401)CAC>CAT	p.H467H	TRIML1_uc003izn.1_Silent_p.H191H	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	467	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TGAACAGCCACGTCTGAGGGG	0.542000													61	188					0	0	0.014410	0	0
PDZD2	23037	broad.mit.edu	37	5	32088593	32088593	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr5:32088593C>T	uc003jhl.2	+	20	5427	c.5039C>T	c.(5038-5040)GCG>GTG	p.A1680V	PDZD2_uc003jhm.2_Missense_Mutation_p.A1680V	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1680					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GAAACTCATGCGGACATAAGC	0.537000													5	359					0	0	0.001984	0	0
ISL1	3670	broad.mit.edu	37	5	50687253	50687253	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr5:50687253A>G	uc003jor.2	+	5	1459	c.911A>G	c.(910-912)GAT>GGT	p.D304G		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	304	Gln-rich.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				AGTGACATAGATCAGCCTGCT	0.488000													60	193					0	0	0.014410	0	0
ZNF608	57507	broad.mit.edu	37	5	123979375	123979375	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr5:123979375C>T	uc003ktq.1	-	6	4248	c.4125G>A	c.(4123-4125)GGG>GGA	p.G1375G	ZNF608_uc003ktr.1_RNA|ZNF608_uc003ktp.1_Silent_p.G70G	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1375						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		AGAGATATGCCCCTGCAGATA	0.388000													34	116					0	0	0.004878	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595866	140595866	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr5:140595866G>A	uc003lja.1	+	1	2358	c.2171G>A	c.(2170-2172)CGC>CAC	p.R724H		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	724	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTGGGTCGCTGCTTGGTG	0.642000													52	623					0	0	0.014410	0	0
EDN1	1906	broad.mit.edu	37	6	12294314	12294314	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr6:12294314C>A	uc003nae.3	+	3	708	c.374C>A	c.(373-375)GCA>GAA	p.A125E	EDN1_uc003nad.2_Missense_Mutation_p.A125E|EDN1_uc003naf.3_Missense_Mutation_p.A124E	NM_001955	NP_001946	P05305	EDN1_HUMAN	endothelin 1 precursor	125					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			skin(1)	1	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				TTTTGCCAAGCAGGAAAAGAA	0.433000													48	158					4.17463e-26	4.65632e-26	0.014410	1	0
RNF5	6048	broad.mit.edu	37	6	32147865	32147865	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr6:32147865C>T	uc003oaj.3	+	5	534	c.407C>T	c.(406-408)ACC>ATC	p.T136I	AGPAT1_uc003oaf.2_5'Flank|AGPAT1_uc003oag.2_5'Flank|AGPAT1_uc003oah.2_5'Flank	NM_006913	NP_008844	Q99942	RNF5_HUMAN	ring finger protein 5	136	Helical; (Potential).				ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						TTTTTCACCACCGTCTTCAAT	0.557000													6	456					0	0	0.001168	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333342	33333342	+	Silent	SNP	G	A	A	rs140475230	by1000genomes	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr6:33333342G>A	uc003shx.2	-	1	798	c.664C>T	c.(664-666)CTG>TTG	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GGAGGCAGCAGCTTCTCAAGA	0.562000													4	70					0	0	0.001168	0	0
REPS1	85021	broad.mit.edu	37	6	139266682	139266682	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr6:139266682C>T	uc003qii.2	-	3	1009	c.430G>A	c.(430-432)GTA>ATA	p.V144I	REPS1_uc003qig.3_Missense_Mutation_p.V144I|REPS1_uc011edr.1_Missense_Mutation_p.V144I|REPS1_uc003qij.2_Missense_Mutation_p.V144I|REPS1_uc003qik.2_5'UTR	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	144						coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		TCATGGCTTACGGATCCCTTT	0.468000													61	751					0	0	0.014410	0	0
TAGAP	117289	broad.mit.edu	37	6	159461826	159461826	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr6:159461826G>T	uc003qrz.2	-	7	848	c.516C>A	c.(514-516)AGC>AGA	p.S172R	TAGAP_uc011eft.1_Missense_Mutation_p.S109R|TAGAP_uc003qsa.2_5'UTR|TAGAP_uc003qsb.2_Missense_Mutation_p.S172R|uc003qsc.2_5'Flank	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	172	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CAAAGAGGTCGCTTGAAAGTA	0.517000													88	238					1.63847e-34	1.85607e-34	0.014410	1	0
MYL7	58498	broad.mit.edu	37	7	44179123	44179123	+	Silent	SNP	A	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:44179123A>T	uc003tkg.2	-	6	435	c.423T>A	c.(421-423)GCT>GCA	p.A141A		NM_021223	NP_067046	Q01449	MLRA_HUMAN	myosin light chain 2a	141	EF-hand 3.				actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity				0						GCCTCACCTCAGCTGGAGAGA	0.587000													34	459					0	0	0.004289	0	0
PKD1L1	168507	broad.mit.edu	37	7	47867033	47867033	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:47867033G>T	uc003tny.1	-	45	6769	c.6769C>A	c.(6769-6771)CGC>AGC	p.R2257S	C7orf69_uc003toa.1_Intron|PKD1L1_uc003tob.2_5'UTR	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2257	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TGCGCCCAGCGCAGGTGGCGA	0.662000													40	140					4.92203e-23	5.44804e-23	0.006230	1	0
TBL2	26608	broad.mit.edu	37	7	72992802	72992802	+	Silent	SNP	C	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:72992802C>T	uc003tyh.2	-	1	212	c.78G>A	c.(76-78)GCG>GCA	p.A26A	TBL2_uc011kex.1_5'Flank|TBL2_uc010lbg.2_5'UTR|TBL2_uc003tyi.2_5'UTR|TBL2_uc011key.1_5'UTR|TBL2_uc010lbh.2_5'UTR	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	26											0		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCCGCGCTACCGCCGCCGTCG	0.736000													3	16					0	0	0.004672	0	0
TRIM74	378108	broad.mit.edu	37	7	75028265	75028265	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:75028265T>A	uc003udc.1	+	2	248	c.48T>A	c.(46-48)TGT>TGA	p.C16*	TRIM74_uc010ldc.2_Nonsense_Mutation_p.C16*|TRIM74_uc010ldd.2_Nonsense_Mutation_p.C16*	NM_198924	NP_944606	Q86UV6	TRI74_HUMAN	tripartite motif-containing 73	16	RING-type.					intracellular	zinc ion binding				0						GGCTTCAGTGTCCCATCTGCC	0.607000													62	482					0	0	0.014410	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100006188	100006188	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:100006188G>C	uc003uut.2	-	10	1211	c.963C>G	c.(961-963)ATC>ATG	p.I321M	ZCWPW1_uc011kjq.1_Missense_Mutation_p.I201M|ZCWPW1_uc003uur.2_Missense_Mutation_p.I201M|ZCWPW1_uc003uus.2_Missense_Mutation_p.I201M|ZCWPW1_uc011kjr.1_Missense_Mutation_p.I321M|ZCWPW1_uc003uuu.1_Missense_Mutation_p.I322M|ZCWPW1_uc011kjs.1_Missense_Mutation_p.I201M|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	321	PWWP.						zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCTTGGCCCAGATGATGGATC	0.512000													119	348					0	0	0.014410	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881419	142881419	+	Missense_Mutation	SNP	A	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:142881419A>C	uc011ksw.1	+	1	908	c.908A>C	c.(907-909)TAC>TCC	p.Y303S		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	303	Helical; Name=7; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					ATGGCTGCCTACCCTGCCAGC	0.458000													11	172					0	0	0.008361	0	0
ZNF746	155061	broad.mit.edu	37	7	149172440	149172440	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr7:149172440C>G	uc003wfw.2	-	7	1241	c.970G>C	c.(970-972)GCC>CCC	p.A324P	ZNF746_uc010lpi.2_Missense_Mutation_p.A325P	NM_152557	NP_689770	Q6NUN9	ZN746_HUMAN	zinc finger protein 746 isoform 2	324					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|breast(1)	3	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CCTTCCTGGGCAGGACTAGGG	0.652000													32	150					0	0	0.010818	0	0
UNC5D	137970	broad.mit.edu	37	8	35606156	35606156	+	Silent	SNP	C	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr8:35606156C>A	uc003xjr.1	+	12	2206	c.1878C>A	c.(1876-1878)GTC>GTA	p.V626V	UNC5D_uc003xjs.1_Silent_p.V621V|UNC5D_uc003xju.1_Silent_p.V202V	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	626	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GTGCAGATGTCAGTTCTGAGC	0.488000													8	583					1.12685e-05	1.18401e-05	0.004482	1	0
OSR2	116039	broad.mit.edu	37	8	99961496	99961496	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr8:99961496C>G	uc003yir.2	+	2	851	c.316C>G	c.(316-318)CTC>GTC	p.L106V	OSR2_uc010mbn.2_Missense_Mutation_p.L106V|OSR2_uc003yiq.2_Missense_Mutation_p.L106V|OSR2_uc011lgx.1_Missense_Mutation_p.L227V	NM_001142462	NP_001135934	Q8N2R0	OSR2_HUMAN	odd-skipped related 2 isoform a	106					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			central_nervous_system(1)	1	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			TGCCCACGTCCTCCCAGCCCT	0.657000													69	539					0	0	0.014410	0	0
VPS13B	157680	broad.mit.edu	37	8	100654306	100654306	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr8:100654306G>T	uc003yiv.2	+	34	5674	c.5563G>T	c.(5563-5565)GCC>TCC	p.A1855S	VPS13B_uc003yiw.2_Missense_Mutation_p.A1830S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1855					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCCTGTATGGCCTTATCCAA	0.343000													72	198					1.74474e-33	1.96115e-33	0.014410	1	0
PHF20L1	51105	broad.mit.edu	37	8	133844624	133844624	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr8:133844624C>G	uc003ytt.2	+	15	2214	c.1889C>G	c.(1888-1890)TCC>TGC	p.S630C	PHF20L1_uc011lja.1_Missense_Mutation_p.S604C	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	630							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GCAATTCTATCCGTTGATCTT	0.398000													68	251					0	0	0.014410	0	0
DENND3	22898	broad.mit.edu	37	8	142151324	142151324	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr8:142151324G>A	uc003yvy.2	+	4	562	c.284G>A	c.(283-285)GGC>GAC	p.G95D	DENND3_uc003yvw.1_Missense_Mutation_p.G108D|DENND3_uc003yvx.2_Missense_Mutation_p.A174T|DENND3_uc010mep.2_Missense_Mutation_p.G108D	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	95										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TTCTACAATGGCAAAACGCAC	0.527000													5	404					0	0	0.001168	0	0
FREM1	158326	broad.mit.edu	37	9	14805125	14805125	+	Silent	SNP	G	A	A			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr9:14805125G>A	uc003zlm.2	-	19	3890	c.3300C>T	c.(3298-3300)AAC>AAT	p.N1100N	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1100	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TGTGAAAAGCGTTCATGTCTT	0.413000													147	464					0	0	0.014410	0	0
ANAPC2	29882	broad.mit.edu	37	9	140079505	140079505	+	Missense_Mutation	SNP	A	C	C			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr9:140079505A>C	uc004clr.1	-	4	981	c.908T>G	c.(907-909)GTG>GGG	p.V303G	ANAPC2_uc004clq.1_Missense_Mutation_p.V162G	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	303					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CTGCAGGAACACCTTGCCGAG	0.672000													9	30					0	0	0.010729	0	0
EHMT1	79813	broad.mit.edu	37	9	140637837	140637837	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr9:140637837G>T	uc011mfc.1	+	5	875	c.838G>T	c.(838-840)GTT>TTT	p.V280F	EHMT1_uc004coa.2_Missense_Mutation_p.V280F|EHMT1_uc004cob.1_Missense_Mutation_p.V249F|EHMT1_uc010ncn.1_RNA	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	280					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		cttgccttttgttttAGCAGC	0.264000													11	58					6.72482e-11	7.27686e-11	0.003163	1	0
GLOD5	392465	broad.mit.edu	37	X	48624287	48624287	+	Silent	SNP	A	G	G			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chrX:48624287A>G	uc011mmh.1	+	2	152	c.111A>G	c.(109-111)AGA>AGG	p.R37R	GLOD5_uc004dko.1_Silent_p.R37R	NM_001080489	NP_001073958			glyoxalase domain containing 5												0						TTATCCGTAGACTTGACCACA	0.458000													4	35					0	0	0.009096	0	0
TRO	7216	broad.mit.edu	37	X	54949027	54949027	+	Missense_Mutation	SNP	C	T	T	rs60180407		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chrX:54949027C>T	uc004dtq.2	+	3	169	c.62C>T	c.(61-63)CCG>CTG	p.P21L	TRO_uc011moj.1_5'UTR|TRO_uc004dts.2_Missense_Mutation_p.P21L|TRO_uc004dtr.2_Missense_Mutation_p.P21L|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	21					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CTGCCTCCCCCGGGGAGCCTG	0.577000													28	34					0	0	0.010818	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52991653	52991653	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:52991653delT	uc001ctx.2	-	2	534	c.300delA	c.(298-300)AAAfs	p.K100fs	ZCCHC11_uc001cty.2_Frame_Shift_Del_p.K100fs|ZCCHC11_uc001ctz.2_Frame_Shift_Del_p.K100fs|ZCCHC11_uc009vze.1_Frame_Shift_Del_p.K100fs|ZCCHC11_uc009vzf.1_Intron|ZCCHC11_uc001cub.2_Frame_Shift_Del_p.K100fs|ZCCHC11_uc001cuc.2_RNA|ZCCHC11_uc001cud.2_Frame_Shift_Del_p.K100fs	NM_015269	NP_056084	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11 isoform	100					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)|skin(1)	3						AATTAGGAAATTTTTTTGCTT	0.388													11	741	---	---	---	---					
POU2F1	5451	broad.mit.edu	37	1	167385016	167385018	+	In_Frame_Del	DEL	CCA	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:167385016_167385018delCCA	uc001gec.2	+	17	2363_2365	c.2201_2203delCCA	c.(2200-2205)TCCACC>TCC	p.T738del	POU2F1_uc001ged.2_In_Frame_Del_p.T736del|POU2F1_uc001gee.2_In_Frame_Del_p.T738del|POU2F1_uc010plh.1_In_Frame_Del_p.T675del|POU2F1_uc001gef.2_In_Frame_Del_p.T750del|POU2F1_uc001geg.2_Intron	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	738					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						GGGGCTGCGTCCACCACCACCAC	0.601													8	769	---	---	---	---					
PIK3C2B	5287	broad.mit.edu	37	1	204438072	204438072	+	Frame_Shift_Del	DEL	G	-	-	rs115574296	by1000genomes	TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:204438072delG	uc001haw.2	-	3	1338	c.859delC	c.(859-861)CGCfs	p.R287fs	PIK3C2B_uc010pqv.1_Frame_Shift_Del_p.R287fs|PIK3C2B_uc001hax.1_Frame_Shift_Del_p.R287fs|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	287	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCATAGGTGCGGGGGGGCACC	0.622													8	614	---	---	---	---					
PLD5	200150	broad.mit.edu	37	1	242451806	242451814	+	In_Frame_Del	DEL	TCAGGAATA	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr1:242451806_242451814delTCAGGAATA	uc001hzn.1	-	3	472_480	c.345_353delTATTCCTGA	c.(343-354)AATATTCCTGAA>AAA	p.115_118NIPE>K	PLD5_uc001hzl.3_In_Frame_Del_p.53_56NIPE>K|PLD5_uc001hzm.3_Intron|PLD5_uc001hzo.1_In_Frame_Del_p.23_26NIPE>K			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	115_118						integral to membrane	catalytic activity	p.T115M(1)		ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GTTAAGGCCTTCAGGAATATTTTCCACCA	0.349													20	135	---	---	---	---					
ARAP1	116985	broad.mit.edu	37	11	72418409	72418411	+	In_Frame_Del	DEL	CAG	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr11:72418409_72418411delCAG	uc001osu.2	-	12	1721_1723	c.1532_1534delCTG	c.(1531-1536)GCTGAC>GAC	p.A511del	ARAP1_uc001osv.2_In_Frame_Del_p.A511del|ARAP1_uc001osr.2_In_Frame_Del_p.A271del|ARAP1_uc001oss.2_In_Frame_Del_p.A266del|ARAP1_uc009yth.2_In_Frame_Del_p.A266del|ARAP1_uc010rre.1_In_Frame_Del_p.A266del	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	511	PH 2.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						AGCTCTGAGTCAGCAGAGAAGCT	0.606													15	128	---	---	---	---					
PDXDC1	23042	broad.mit.edu	37	16	15102650	15102650	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr16:15102650delC	uc002dda.3	+	7	818	c.594delC	c.(592-594)TTCfs	p.F198fs	PDXDC1_uc010uzl.1_Frame_Shift_Del_p.F183fs|PDXDC1_uc010uzm.1_Frame_Shift_Del_p.F107fs|PDXDC1_uc010bvc.1_Frame_Shift_Del_p.F139fs|PDXDC1_uc002dcz.2_Intron|PDXDC1_uc002ddb.3_Frame_Shift_Del_p.F171fs|PDXDC1_uc010uzn.1_Frame_Shift_Del_p.F170fs|PDXDC1_uc002ddc.2_Frame_Shift_Del_p.F198fs	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	198					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GCTTGCCCTTCCCCTGCTTGT	0.463													168	1236	---	---	---	---					
UTP3	57050	broad.mit.edu	37	4	71554620	71554622	+	In_Frame_Del	DEL	GAG	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr4:71554620_71554622delGAG	uc003hfo.2	+	1	425_427	c.226_228delGAG	c.(226-228)GAGdel	p.E81del		NM_020368	NP_065101	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit processome component	81	Glu-rich.				brain development|chromatin modification|gene silencing	nucleolus					0			Lung(101;0.235)			ggaggatggcgaggaggaggagg	0.291													8	224	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr4:134073569_134073571delCTG	uc003iha.2	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)CTCTGC>CTC	p.C763del	PCDH10_uc003igz.2_In_Frame_Del_p.C763del	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	763	Cys-rich.|Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													8	214	---	---	---	---					
KIAA1432	57589	broad.mit.edu	37	9	5743708	5743708	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr9:5743708delA	uc003zji.2	+	9	922	c.829delA	c.(829-831)AAAfs	p.K277fs	KIAA1432_uc003zjh.2_Frame_Shift_Del_p.K277fs|KIAA1432_uc003zjl.3_Frame_Shift_Del_p.K277fs|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	356						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGATGGCACCAAAAAAGATCC	0.279													8	1064	---	---	---	---					
MPDZ	8777	broad.mit.edu	37	9	13247684	13247709	+	Frame_Shift_Del	DEL	AGAGAGGGCTCTGCAGGACTGACTTC	-	-	rs113647522		TCGA-FQ-6553-01A-11D-1795-08	TCGA-FQ-6553-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	8632b516-aa57-492f-b295-92b67113f7d8	4c246184-2309-45ce-bb69-f37f0a68ce52	g.chr9:13247684_13247709delAGAGAGGGCTCTGCAGGACTGACTTC	uc010mia.1	-	2	165_190	c.108_133delGAAGTCAGTCCTGCAGAGCCCTCTCT	c.(106-135)CTGAAGTCAGTCCTGCAGAGCCCTCTCTTCfs	p.L36fs	MPDZ_uc010mhy.2_Frame_Shift_Del_p.L36fs|MPDZ_uc010mhz.2_Frame_Shift_Del_p.L36fs|MPDZ_uc011lmn.1_Frame_Shift_Del_p.L36fs|MPDZ_uc003zlb.3_Frame_Shift_Del_p.L36fs	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	36_45	L27.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		ATCTGACTGAAGAGAGGGCTCTGCAGGACTGACTTCAGAAGGCTCA	0.500													16	475	---	---	---	---					
