Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA0467	23334	broad.mit.edu	37	1	43891307	43891307	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:43891307G>A	uc001cjk.1	+	5	744	c.282G>A	c.(280-282)CCG>CCA	p.P94P	KIAA0467_uc009vws.1_Silent_p.P936P	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	936						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGAGATCCCGCAAGCTGTGA	0.577000													6	362					0	0	0.001168	0	0
C1orf175	374977	broad.mit.edu	37	1	55172176	55172176	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:55172176G>A	uc010ooe.1	+	22	3957	c.3633G>A	c.(3631-3633)CGG>CGA	p.R1211R	C1orf175_uc001cxq.2_RNA|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Silent_p.R729R|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Silent_p.R412R	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	1211						integral to membrane	binding				0						AGAACTCACGGGCCTCCCTCC	0.557000													10	434					0	0	0.006214	0	0
LRRC7	57554	broad.mit.edu	37	1	70504178	70504178	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:70504178G>A	uc001dep.2	+	19	2587	c.2557G>A	c.(2557-2559)GAA>AAA	p.E853K	LRRC7_uc009wbg.2_Missense_Mutation_p.E137K|LRRC7_uc001deq.2_Missense_Mutation_p.E94K	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	853						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TAGTCCGTTTGAAGACAGGAC	0.478000													10	356					0	0	0.006214	0	0
NBPF10	100132406	broad.mit.edu	37	1	145296373	145296373	+	Missense_Mutation	SNP	G	T	T	rs3969711		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:145296373G>T	uc001end.3	+	3	330	c.295G>T	c.(295-297)GTT>TTT	p.V99F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.V99F|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	99											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TAAAGTCCTAGTTCACTCTCA	0.473000													7	773					4.7546e-09	5.17413e-09	0.004007	1	0
KPRP	448834	broad.mit.edu	37	1	152732254	152732254	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:152732254C>T	uc001fal.1	+	2	248	c.190C>T	c.(190-192)CCA>TCA	p.P64S		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	64	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCAGGCTCCATGCCAGTC	0.557000													19	447					0	0	0.007413	0	0
TRIM46	80128	broad.mit.edu	37	1	155149423	155149423	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:155149423G>A	uc001fhs.1	+	4	768	c.685G>A	c.(685-687)GAC>AAC	p.D229N	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Missense_Mutation_p.D216N|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Missense_Mutation_p.D229N|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Missense_Mutation_p.D103N|TRIM46_uc001fhu.1_Missense_Mutation_p.D206N|TRIM46_uc009wpg.1_Missense_Mutation_p.D216N|TRIM46_uc001fhv.3_Missense_Mutation_p.D216N|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	229	RING-type 2; degenerate.|B box-type.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TATGTGCCCAGACCACAAGGA	0.562000											OREG0013855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	519					0	0	0.012319	0	0
CD1D	912	broad.mit.edu	37	1	158153926	158153926	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:158153926C>T	uc001frr.2	+	7	1493	c.994C>T	c.(994-996)CAG>TAG	p.Q332*	CD1D_uc009wss.2_Nonsense_Mutation_p.Q239*	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	332	Cytoplasmic (Potential).|Internalization signal.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CAGTTCCTATCAGGGCGTCCT	0.512000													14	468					0	0	0.003163	0	0
GLUL	2752	broad.mit.edu	37	1	182355410	182355410	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:182355410G>A	uc001gpa.1	-	4	668	c.456C>T	c.(454-456)AAC>AAT	p.N152N	GLUL_uc010pnt.1_5'Flank|GLUL_uc001gpb.1_Silent_p.N152N|GLUL_uc001gpc.1_Silent_p.N152N|GLUL_uc001gpd.1_Silent_p.N152N	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	152					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	CTGGGAAGCCGTTGGAAGGCC	0.562000													28	552					0	0	0.006320	0	0
EDEM3	80267	broad.mit.edu	37	1	184692968	184692968	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:184692968T>A	uc010pok.1	-	8	1031	c.770A>T	c.(769-771)GAT>GTT	p.D257V	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.D257V|EDEM3_uc001gqy.2_Missense_Mutation_p.D180V	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	257					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						CCAGAGAAAATCAAGAGCTTT	0.318000													8	405					0	0	0.008291	0	0
PRG4	10216	broad.mit.edu	37	1	186275982	186275982	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:186275982C>T	uc001gru.3	+	7	1182	c.1131C>T	c.(1129-1131)ACC>ACT	p.T377T	PRG4_uc001grt.3_Silent_p.T336T|PRG4_uc009wyl.2_Silent_p.T284T|PRG4_uc009wym.2_Silent_p.T243T|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	377	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|4; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCCACCACCCCCAAGGAGC	0.637000													7	486					0	0	0.003080	0	0
IARS2	55699	broad.mit.edu	37	1	220320859	220320859	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:220320859C>A	uc001hmc.2	+	23	3025	c.2921C>A	c.(2920-2922)TCC>TAC	p.S974Y	IARS2_uc001hmd.2_Missense_Mutation_p.S310Y	NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	974					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	GAAGAGTCTTCCTATAAAGTA	0.388000													9	290					7.48243e-07	7.9669e-07	0.006214	1	0
MARK1	4139	broad.mit.edu	37	1	220825334	220825334	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:220825334G>A	uc001hmn.3	+	15	2175	c.1578G>A	c.(1576-1578)ACG>ACA	p.T526T	MARK1_uc009xdw.2_Silent_p.T526T|MARK1_uc010pun.1_Silent_p.T526T|MARK1_uc001hmm.3_Silent_p.T504T	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	526					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AAAGCCTTACGGAGATGTCTG	0.428000													9	424					0	0	0.010729	0	0
PCDH15	65217	broad.mit.edu	37	10	55944974	55944974	+	Missense_Mutation	SNP	C	T	T	rs61735473	byFrequency	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr10:55944974C>T	uc001jju.1	-	12	1755	c.1360G>A	c.(1360-1362)GTC>ATC	p.V454I	PCDH15_uc010qhq.1_Missense_Mutation_p.V459I|PCDH15_uc010qhr.1_Missense_Mutation_p.V454I|PCDH15_uc010qhs.1_Missense_Mutation_p.V466I|PCDH15_uc010qht.1_Missense_Mutation_p.V461I|PCDH15_uc010qhu.1_Missense_Mutation_p.V454I|PCDH15_uc001jjv.1_Missense_Mutation_p.V432I|PCDH15_uc010qhv.1_Missense_Mutation_p.V454I|PCDH15_uc010qhw.1_Missense_Mutation_p.V417I|PCDH15_uc010qhx.1_Missense_Mutation_p.V454I|PCDH15_uc010qhy.1_Missense_Mutation_p.V459I|PCDH15_uc010qhz.1_Missense_Mutation_p.V454I|PCDH15_uc010qia.1_Missense_Mutation_p.V432I|PCDH15_uc010qib.1_Missense_Mutation_p.V432I|PCDH15_uc001jjw.2_Missense_Mutation_p.V454I	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	454	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding	p.V454I(1)		pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GTCTGTGTGACGGTGAAGACT	0.393000										HNSCC(58;0.16)			6	302					0	0	0.001168	0	0
GRK5	2869	broad.mit.edu	37	10	121189945	121189945	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr10:121189945G>A	uc001led.2	+	7	825	c.592G>A	c.(592-594)GGG>AGG	p.G198R	GRK5_uc009xzh.2_Missense_Mutation_p.G93R|GRK5_uc010qta.1_Missense_Mutation_p.G93R	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	198	Protein kinase.|ATP (By similarity).				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		AGGGGGCTTCGGGGAGGTGAG	0.478000													16	484					0	0	0.007413	0	0
HBD	3045	broad.mit.edu	37	11	5255431	5255431	+	Silent	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:5255431G>C	uc001maf.1	-	2	300	c.105C>G	c.(103-105)GTC>GTG	p.V35V		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	35					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCAAGGGTAGACCACCAGTA	0.517000													7	305					0	0	0.001984	0	0
KBTBD4	55709	broad.mit.edu	37	11	47599155	47599155	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:47599155C>T	uc001nfx.2	-	2	568	c.397G>A	c.(397-399)GAA>AAA	p.E133K	NDUFS3_uc001nft.3_Intron|KBTBD4_uc001nfw.1_Missense_Mutation_p.E158K|KBTBD4_uc001nfz.2_Missense_Mutation_p.E149K|KBTBD4_uc001nfy.2_Missense_Mutation_p.E133K|NDUFS3_uc010rhn.1_5'Flank|NDUFS3_uc001nga.2_5'Flank	NM_016506	NP_057590	Q9NVX7	KBTB4_HUMAN	kelch repeat and BTB (POZ) domain containing 4	133										ovary(1)|central_nervous_system(1)	2						CGAGAGCATTCCTCAAAGAGA	0.498000													10	564					0	0	0.006214	0	0
OR5M10	390167	broad.mit.edu	37	11	56345085	56345085	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:56345085G>A	uc001niz.1	-	1	113	c.113C>T	c.(112-114)ACA>ATA	p.T38I		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	38	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCTGCCAGTGTGATTAGGTA	0.478000													7	485					0	0	0.003080	0	0
NXF1	10482	broad.mit.edu	37	11	62571300	62571300	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:62571300G>A	uc001nvf.1	-	2	315	c.179C>T	c.(178-180)GCA>GTA	p.A60V	NXF1_uc001nvg.1_Missense_Mutation_p.A60V|NXF1_uc009yog.1_Missense_Mutation_p.A103V|NXF1_uc010rmh.1_Intron	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	60	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						ATCACTCATTGCCACATCTCC	0.502000													14	669					0	0	0.004007	0	0
MYO7A	4647	broad.mit.edu	37	11	76867758	76867758	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:76867758C>T	uc001oyb.2	+	6	795	c.523C>T	c.(523-525)CTG>TTG	p.L175L	MYO7A_uc010rsl.1_Silent_p.L175L|MYO7A_uc010rsm.1_Silent_p.L164L|MYO7A_uc001oyc.2_Silent_p.L175L	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	175	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCTGCAGTTCCTGGCAGCCAT	0.622000													5	404					0	0	0.000602	0	0
BIRC3	330	broad.mit.edu	37	11	102195891	102195891	+	Silent	SNP	G	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:102195891G>T	uc001pgx.2	+	3	873	c.651G>T	c.(649-651)CCG>CCT	p.P217P		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	217	BIR 2.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		ATTGGGAACCGAAGGATAATG	0.428000			T	MALT1	MALT								17	487					1.33834e-09	1.46721e-09	0.007413	1	0
MMP1	4312	broad.mit.edu	37	11	102663365	102663365	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:102663365G>A	uc001phi.2	-	7	1147	c.1004C>T	c.(1003-1005)GCC>GTC	p.A335V	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.A269V	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	335	Hemopexin-like 2.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		ATCTCTGTCGGCAAATTCGTA	0.393000													5	434					0	0	0.001168	0	0
C11orf57	55216	broad.mit.edu	37	11	111953260	111953260	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:111953260G>A	uc001pmr.3	+	6	1124	c.443G>A	c.(442-444)CGC>CAC	p.R148H	C11orf57_uc001pmw.3_Missense_Mutation_p.R149H|C11orf57_uc001pmt.3_Missense_Mutation_p.R149H|C11orf57_uc001pmv.3_Missense_Mutation_p.R148H|C11orf57_uc001pms.3_Missense_Mutation_p.R120H	NM_001082970	NP_001076439	Q6ZUT1	CK057_HUMAN	hypothetical protein LOC55216 isoform b	148	Lys-rich.									breast(2)|ovary(1)	3		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		CATGAATCCCGCAAACACAAG	0.358000													4	192					0	0	0.000602	0	0
OR10G4	390264	broad.mit.edu	37	11	123886933	123886933	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:123886933G>C	uc010sac.1	+	1	652	c.652G>C	c.(652-654)GTG>CTG	p.V218L		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GCTGTCCTATGTGTCCATCGT	0.542000													8	402					0	0	0.004482	0	0
Unknown	0	broad.mit.edu	37	12	31353407	31353407	+	Missense_Mutation	SNP	T	C	C	rs150206667	by1000genomes	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr12:31353407T>C	uc010sjy.1	-	3	323	c.323A>G	c.(322-324)AAT>AGT	p.N108S						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		AAAGACCACATTCTCTCTGGA	0.443000													4	125					0	0	0.009096	0	0
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr12:106820987C>T	uc001tlp.2	+	13	1336	c.1114C>T	c.(1114-1116)CTT>TTT	p.L372F	POLR3B_uc001tlq.2_Missense_Mutation_p.L314F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCTTCTTTTTGAAGA	0.274000													18	39					0	0	0.010504	0	0
NAA25	80018	broad.mit.edu	37	12	112486222	112486222	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr12:112486222T>G	uc001ttm.2	-	16	1774	c.1754A>C	c.(1753-1755)TAC>TCC	p.Y585S	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.Y557S|NAA25_uc009zwa.1_Missense_Mutation_p.Y585S	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	585						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						ACCATATTTGTAAGCTTGAAT	0.393000													17	259					0	0	0.004990	0	0
DTX1	1840	broad.mit.edu	37	12	113515335	113515335	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr12:113515335T>G	uc001tuk.1	+	2	702	c.366T>G	c.(364-366)GAT>GAG	p.D122E		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	122	WWE 2.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CGGCCTACGATATGGACATCT	0.622000													6	210					0	0	0.001984	0	0
MED13L	23389	broad.mit.edu	37	12	116421998	116421998	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr12:116421998G>A	uc001tvw.2	-	20	4573	c.4518C>T	c.(4516-4518)TGC>TGT	p.C1506C		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1506					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGTGATGGCGGCAAACTTGCG	0.423000													4	148					0	0	0.001168	0	0
SALL2	6297	broad.mit.edu	37	14	21993517	21993517	+	Missense_Mutation	SNP	C	G	G	rs146823588		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr14:21993517C>G	uc001wbe.2	-	2	627	c.345G>C	c.(343-345)GAG>GAC	p.E115D	SALL2_uc010tly.1_Missense_Mutation_p.E113D|SALL2_uc010tlz.1_Missense_Mutation_p.E113D|SALL2_uc001wbf.3_Missense_Mutation_p.E113D|SALL2_uc010tma.1_Missense_Mutation_p.E115D|SALL2_uc001wbg.1_Missense_Mutation_p.E115D	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	115							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTCCTCTCCTCTCTGGGCCCC	0.637000													6	318					0	0	0.001168	0	0
HECTD1	25831	broad.mit.edu	37	14	31647374	31647374	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr14:31647374C>T	uc001wrc.1	-	3	716	c.227G>A	c.(226-228)CGT>CAT	p.R76H		NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	76					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TGTTATGGCACGGGCTGTCAC	0.428000													11	333					0	0	0.008291	0	0
KIF26A	26153	broad.mit.edu	37	14	104640097	104640097	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr14:104640097C>T	uc001yos.3	+	10	1922	c.1922C>T	c.(1921-1923)GCG>GTG	p.A641V		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	641	Kinesin-motor.				blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TGTGAGGCGGCGGCTGGCAGG	0.682000													7	91					0	0	0.001984	0	0
PIGQ	9091	broad.mit.edu	37	16	633183	633183	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr16:633183T>G	uc002cho.2	+	10	1934	c.1832T>G	c.(1831-1833)TTG>TGG	p.L611W	PIGQ_uc010bqw.2_3'UTR|PIGQ_uc002chn.2_3'UTR|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Missense_Mutation_p.L181W|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	611					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				TATCACACCTTGGGCTTGGAG	0.642000													30	622					0	0	0.013726	0	0
PKMYT1	9088	broad.mit.edu	37	16	3024072	3024072	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr16:3024072C>T	uc002csn.2	-	7	1682	c.1239G>A	c.(1237-1239)CCG>CCA	p.P413P	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.P413P|PKMYT1_uc002cso.2_Silent_p.P344P|PKMYT1_uc002csp.2_Silent_p.P404P|PKMYT1_uc002csq.2_Silent_p.P404P|PKMYT1_uc010bsy.1_Silent_p.P404P	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	413	Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						GTGAGCCAGGCGGGGTGGCTG	0.677000													6	87					0	0	0.001168	0	0
DNAH3	55567	broad.mit.edu	37	16	21156640	21156640	+	Missense_Mutation	SNP	G	A	A	rs140968171		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr16:21156640G>A	uc010vbe.1	-	3	310	c.310C>T	c.(310-312)CGT>TGT	p.R104C	DNAH3_uc002die.2_Missense_Mutation_p.R75C	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	104	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTGGGTCCACGGTGGTGATGC	0.532000													6	220					0	0	0.001984	0	0
SPNS1	83985	broad.mit.edu	37	16	28995113	28995113	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr16:28995113G>A	uc010vdi.1	+	12	1467	c.1327G>A	c.(1327-1329)GAC>AAC	p.D443N	uc010vct.1_Intron|SPNS1_uc002drx.2_Missense_Mutation_p.D370N|SPNS1_uc002dsa.2_Missense_Mutation_p.D443N|SPNS1_uc002drz.2_Missense_Mutation_p.D391N|SPNS1_uc010byp.2_Missense_Mutation_p.D369N|SPNS1_uc010byq.1_Intron|LAT_uc010vdj.1_5'Flank|LAT_uc002dsb.2_5'Flank|LAT_uc002dsd.2_5'Flank|LAT_uc002dsc.2_5'Flank|LAT_uc010vdk.1_5'Flank|LAT_uc010vdl.1_5'Flank	NM_001142448	NP_001135920	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 isoform 1	443					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding				0						GCAGATCTCTGACCGCCTGCG	0.642000													9	335					0	0	0.010729	0	0
Unknown	0	broad.mit.edu	37	16	70268080	70268080	+	RNA	SNP	T	C	C	rs149244259	by1000genomes	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr16:70268080T>C	uc010cfp.1	-	3		c.335A>G								Homo sapiens cDNA, FLJ98908.																		GTCTTACTGTTGGCTAAAAGG	0.373000													3	43					0	0	0.004672	0	0
PLD2	5338	broad.mit.edu	37	17	4714240	4714240	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:4714240C>T	uc002fzc.2	+	10	1105	c.1004C>T	c.(1003-1005)GCC>GTC	p.A335V	PLD2_uc010vsj.1_Missense_Mutation_p.A192V|PLD2_uc002fzd.2_Missense_Mutation_p.A335V	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	335					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	GGGACCTTGGCCCGGTGGTGA	0.582000													4	232					0	0	0.000602	0	0
TP53	7157	broad.mit.edu	37	17	7578235	7578235	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:7578235T>A	uc002gim.2	-	6	808	c.614A>T	c.(613-615)TAT>TTT	p.Y205F	TP53_uc002gig.1_Missense_Mutation_p.Y205F|TP53_uc002gih.2_Missense_Mutation_p.Y205F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y73F|TP53_uc010cng.1_Missense_Mutation_p.Y73F|TP53_uc002gii.1_Missense_Mutation_p.Y73F|TP53_uc010cnh.1_Missense_Mutation_p.Y205F|TP53_uc010cni.1_Missense_Mutation_p.Y205F|TP53_uc002gij.2_Missense_Mutation_p.Y205F|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.Y112F|TP53_uc002gio.2_Missense_Mutation_p.Y73F|TP53_uc010vug.1_Missense_Mutation_p.Y166F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	205	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> N (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> C (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y205C(55)|p.Y205D(13)|p.Y205S(11)|p.Y205F(8)|p.0?(7)|p.Y205H(5)|p.Y205*(4)|p.Y205N(2)|p.K164_P219del(1)|p.Y205fs*42(1)|p.Y112C(1)|p.Y205fs*43(1)|p.E204fs*39(1)|p.Y73C(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCATCCAAATACTCCACACG	0.542000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	161					0	0	0.000602	0	0
GOSR1	9527	broad.mit.edu	37	17	28837900	28837900	+	Nonsense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:28837900C>G	uc002hfe.2	+	7	544	c.518C>G	c.(517-519)TCA>TGA	p.S173*	GOSR1_uc002hfd.2_Nonsense_Mutation_p.S171*|GOSR1_uc002hff.2_Nonsense_Mutation_p.S108*	NM_004871	NP_004862	O95249	GOSR1_HUMAN	golgi SNAP receptor complex member 1 isoform 1	173	Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|SNARE complex	SNAP receptor activity				0						ATTTGCAGCTCAGATCGTCTG	0.274000													14	462					0	0	0.002450	0	0
RDM1	201299	broad.mit.edu	37	17	34257132	34257132	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:34257132C>T	uc002hkh.2	-	2	273	c.224G>A	c.(223-225)AGA>AAA	p.R75K	RDM1_uc010cty.2_RNA|RDM1_uc010ctz.2_Missense_Mutation_p.R52K|RDM1_uc010cua.2_Missense_Mutation_p.R52K|RDM1_uc002hkg.3_Missense_Mutation_p.R52K|RDM1_uc010cub.2_RNA|RDM1_uc010cud.2_Missense_Mutation_p.R75K|RDM1_uc010cuf.2_RNA|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_RNA|RDM1_uc010cuc.2_Missense_Mutation_p.R75K|RDM1_uc010wco.1_Missense_Mutation_p.R52K|RDM1_uc010wcp.1_Missense_Mutation_p.R52K|RDM1_uc002hki.2_Missense_Mutation_p.R75K	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	75	RRM.|Necessary for nuclear localization and for nucleolar accumulation in response to heat shock.				DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTTTTGGGCTCTGTGGGCAGC	0.493000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					10	744					0	0	0.006214	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478657	42478657	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:42478657G>A	uc002igw.1	-	8	852	c.788C>T	c.(787-789)GCA>GTA	p.A263V	GPATCH8_uc002igv.1_Missense_Mutation_p.A185V|GPATCH8_uc010wiz.1_Missense_Mutation_p.A185V	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	263						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GATTTGTACTGCAGTGAAAGG	0.488000													13	486					0	0	0.013537	0	0
SCRN2	90507	broad.mit.edu	37	17	45916005	45916005	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:45916005C>T	uc002imd.2	-	6	956	c.830G>A	c.(829-831)TGT>TAT	p.C277Y	SCRN2_uc002imc.2_Missense_Mutation_p.C285Y|SCRN2_uc002imf.2_Missense_Mutation_p.C277Y|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	277					proteolysis		dipeptidase activity			ovary(1)	1						CGAGTCCATACAGATACCACT	0.622000													14	226					0	0	0.001855	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48597009	48597009	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:48597009G>A	uc010wmr.1	+	7	1068	c.906G>A	c.(904-906)GAG>GAA	p.E302E	MYCBPAP_uc002iqx.2_Silent_p.E302E|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	265					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			AGAGCTGGGAGAACAGTGGGT	0.532000													5	227					0	0	0.001168	0	0
HLF	3131	broad.mit.edu	37	17	53345301	53345301	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:53345301C>T	uc002iug.1	+	2	830	c.305C>T	c.(304-306)TCT>TTT	p.S102F	HLF_uc010dce.1_Missense_Mutation_p.S17F|HLF_uc002iuh.2_Missense_Mutation_p.S17F|HLF_uc010wni.1_Missense_Mutation_p.L51F	NM_002126	NP_002117	Q16534	HLF_HUMAN	hepatic leukemia factor	102					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CCCAGCCCATCTCAGCATGAC	0.577000			T	TCF3	ALL								41	539					0	0	0.008740	0	0
TEX14	56155	broad.mit.edu	37	17	56649402	56649402	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:56649402C>T	uc010dcz.1	-	25	3853	c.3735G>A	c.(3733-3735)TGG>TGA	p.W1245*	TEX14_uc002iwr.1_Nonsense_Mutation_p.W1239*|TEX14_uc002iws.1_Nonsense_Mutation_p.W1199*|TEX14_uc010dda.1_Nonsense_Mutation_p.W979*	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1245						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTGACTGTTCCAGCAAGAGG	0.423000													6	481					0	0	0.001984	0	0
THOC1	9984	broad.mit.edu	37	18	214689	214689	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr18:214689C>T	uc002kkj.3	-	21	1951	c.1911G>A	c.(1909-1911)CTG>CTA	p.L637L	THOC1_uc002kkk.3_RNA|THOC1_uc002kkh.3_Silent_p.L261L	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	637	Death.				apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				CAGACTTATTCAGTGCATTAA	0.378000													9	394					0	0	0.006214	0	0
SMAD4	4089	broad.mit.edu	37	18	48575152	48575152	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr18:48575152C>T	uc010xdp.1	+	3	884	c.346C>T	c.(346-348)CAG>TAG	p.Q116*	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	116	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)|p.Q116*(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TAAATATTGTCAGTATGCGTT	0.408000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				10	235					0	0	0.006214	0	0
MEX3C	51320	broad.mit.edu	37	18	48702760	48702760	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr18:48702760G>A	uc002lfc.3	-	2	1941	c.1941C>T	c.(1939-1941)TGC>TGT	p.C647C		NM_016626	NP_057710	Q5U5Q3	MEX3C_HUMAN	ring finger and KH domain containing 2	647	RING-type.					cytoplasm|nucleus	RNA binding|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		CAGCTGTCTGGCAAACTGGAC	0.403000													5	442					0	0	0.001168	0	0
ZNF516	9658	broad.mit.edu	37	18	74091560	74091560	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr18:74091560C>T	uc010dqx.1	-	3	2745	c.2510G>A	c.(2509-2511)CGC>CAC	p.R837H	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	837					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CACCTGAGTGCGGGTGAACCG	0.602000													5	429					0	0	0.001168	0	0
HNRNPM	4670	broad.mit.edu	37	19	8551181	8551181	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:8551181C>T	uc010dwe.2	+	14	1949	c.1869C>T	c.(1867-1869)ATC>ATT	p.I623I	HNRNPM_uc010xke.1_Silent_p.I569I|HNRNPM_uc010dwd.2_Silent_p.I584I|HNRNPM_uc002mka.2_Silent_p.I488I|HNRNPM_uc002mkb.1_5'Flank	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	623					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						ACCGTGCCATCGAGATGGAGC	0.662000													4	191					0	0	0.009096	0	0
MAST1	22983	broad.mit.edu	37	19	12979463	12979463	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:12979463G>A	uc002mvm.2	+	21	2701	c.2573G>A	c.(2572-2574)CGT>CAT	p.R858H		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	858					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GCAGCTGACCGTCCACGCCCA	0.448000													12	452					0	0	0.001855	0	0
GMIP	51291	broad.mit.edu	37	19	19749084	19749084	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:19749084C>T	uc002nnd.2	-	9	790	c.673G>A	c.(673-675)GAG>AAG	p.E225K	GMIP_uc010xrb.1_Missense_Mutation_p.E225K|GMIP_uc010xrc.1_Missense_Mutation_p.E225K	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	225					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						CGCAGGTCCTCGCTGCGTTGC	0.706000													4	86					0	0	0.000602	0	0
ZNF430	80264	broad.mit.edu	37	19	21240178	21240178	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:21240178A>G	uc002npj.2	+	5	1174	c.1064A>G	c.(1063-1065)AAC>AGC	p.N355S	ZNF430_uc002npk.2_Missense_Mutation_p.N354S	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	355	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						AAAGCTTTTAACCAATCCTCA	0.388000													4	347					0	0	0.001168	0	0
KIAA0355	9710	broad.mit.edu	37	19	34832997	34832997	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:34832997C>T	uc002nvd.3	+	10	3017	c.2158C>T	c.(2158-2160)CAG>TAG	p.Q720*		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	720										ovary(1)	1	Esophageal squamous(110;0.162)					ACTGGCACCTCAGCAGCAGTC	0.657000													13	501					0	0	0.013537	0	0
ZFP112	7771	broad.mit.edu	37	19	44840866	44840866	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:44840866G>A	uc010ejj.2	-	4	261	c.148C>T	c.(148-150)CAG>TAG	p.Q50*	ZFP112_uc002ozc.3_Nonsense_Mutation_p.Q44*|ZFP112_uc010xwy.1_Nonsense_Mutation_p.Q67*|ZFP112_uc010xwz.1_Nonsense_Mutation_p.Q49*	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	50	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTGAAGGGCTGATGTGCTGTA	0.338000													5	408					0	0	0.001168	0	0
NR1H2	7376	broad.mit.edu	37	19	50881940	50881940	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:50881940G>A	uc010enw.2	+	7	913	c.637G>A	c.(637-639)GGG>AGG	p.G213R	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.G212R|NR1H2_uc002psa.3_Missense_Mutation_p.G115R	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	212					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CCAGGGCTCCGGGGAAGGCGA	0.642000													4	145					0	0	0.009096	0	0
ZNF432	9668	broad.mit.edu	37	19	52538670	52538670	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:52538670G>A	uc002pyk.2	-	5	580	c.262C>T	c.(262-264)CTG>TTG	p.L88L		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TGATCCTGCAGATGATCATCA	0.353000													6	289					0	0	0.006214	0	0
ZNF836	162962	broad.mit.edu	37	19	52659049	52659049	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:52659049C>G	uc010ydi.1	-	5	2261	c.1887G>C	c.(1885-1887)AAG>AAC	p.K629N	ZNF836_uc010ydj.1_Missense_Mutation_p.K629N	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	629	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TATGAATTCTCTTATGATTTG	0.423000													9	839					0	0	0.004482	0	0
ZNF525	170958	broad.mit.edu	37	19	53884439	53884439	+	Missense_Mutation	SNP	A	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:53884439A>T	uc010eqn.2	+	4	692	c.499A>T	c.(499-501)ACA>TCA	p.T167S	ZNF525_uc002qbl.2_Intron|ZNF765_uc010ydx.1_Intron	NR_003699				Homo sapiens cDNA FLJ39718 fis, clone SMINT2013695.												0						TTCATTACTCACACAAAGACA	0.363000													34	361					0	0	0.012213	0	0
NLRP4	147945	broad.mit.edu	37	19	56388361	56388361	+	Splice_Site	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:56388361G>A	uc002qmd.3	+	8	2948	c.2526_splice	c.e8-1	p.C842_splice	NLRP4_uc002qmf.2_Splice_Site_p.C767_splice|NLRP4_uc010etf.2_Splice_Site_p.C617_splice	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4								ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTCCTTTGCAGTTTGGTAAAA	0.433000													35	765					0	0	0.003755	0	0
ZNF776	284309	broad.mit.edu	37	19	58265822	58265822	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr19:58265822C>T	uc002qpx.2	+	3	1547	c.1324C>T	c.(1324-1326)CAT>TAT	p.H442Y	ZNF587_uc002qqb.2_Intron|ZNF776_uc002qqa.2_Missense_Mutation_p.H442Y	NM_173632	NP_775903	Q68DI1	ZN776_HUMAN	zinc finger protein 776	442	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		GAAATGTTTTCATCAAAAGGG	0.433000													16	429					0	0	0.006122	0	0
FAM98A	25940	broad.mit.edu	37	2	33813518	33813518	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:33813518C>T	uc002rpa.1	-	4	480	c.406G>A	c.(406-408)GAA>AAA	p.E136K	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Missense_Mutation_p.E13K	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	136										ovary(1)	1	all_hematologic(175;0.115)					CCGCCTCCTTCTTGAGCTTTT	0.403000													7	384					0	0	0.003080	0	0
VWA3B	200403	broad.mit.edu	37	2	98916551	98916551	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:98916551T>C	uc002syo.2	+	25	3556	c.3292T>C	c.(3292-3294)TAT>CAT	p.Y1098H	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.Y755H|VWA3B_uc002syp.1_Missense_Mutation_p.Y490H|VWA3B_uc002syq.1_Missense_Mutation_p.Y374H|VWA3B_uc002syr.1_Missense_Mutation_p.Y415H|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1098										ovary(3)|large_intestine(2)|skin(1)	6						GGTTGGAGATTATGTGTTTGC	0.373000													21	686					0	0	0.003954	0	0
RNF149	284996	broad.mit.edu	37	2	101911492	101911492	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:101911492C>T	uc002taz.1	-	2	714	c.612G>A	c.(610-612)GTG>GTA	p.V204V	RNF149_uc002tax.1_RNA	NM_173647	NP_775918	Q8NC42	RN149_HUMAN	ring finger protein 149 precursor	204	Helical; (Potential).					integral to membrane	ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AGGCAATGGCCACAAACACCA	0.458000													9	353					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179446372	179446372	+	Nonsense_Mutation	SNP	A	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:179446372A>C	uc010zfg.1	-	265	59143	c.58919T>G	c.(58918-58920)TTA>TGA	p.L19640*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.L13335*|TTN_uc010zfi.1_Nonsense_Mutation_p.L13268*|TTN_uc010zfj.1_Nonsense_Mutation_p.L13143*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20567							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCTGTGGTAAGTTGCACCT	0.473000													3	156					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179482926	179482926	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:179482926C>A	uc010zfg.1	-	201	39779	c.39555G>T	c.(39553-39555)AGG>AGT	p.R13185S	TTN_uc010zfh.1_Missense_Mutation_p.R6880S|TTN_uc010zfi.1_Missense_Mutation_p.R6813S|TTN_uc010zfj.1_Missense_Mutation_p.R6688S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14112							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATATTTACTCCTTGCTTCTA	0.388000													14	710					6.72482e-11	7.42742e-11	0.003163	1	0
TTN	7273	broad.mit.edu	37	2	179547505	179547505	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:179547505G>T	uc010zfg.1	-	132	29505	c.29281C>A	c.(29281-29283)CCA>ACA	p.P9761T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6422T|TTN_uc010fre.1_Missense_Mutation_p.P608T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10688							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTCTGTTGGTTCATACTCC	0.368000													16	652					4.96729e-08	5.36612e-08	0.008871	1	0
HJURP	55355	broad.mit.edu	37	2	234761262	234761262	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:234761262C>G	uc002vvg.2	-	3	255	c.189G>C	c.(187-189)TTG>TTC	p.L63F	HJURP_uc010znd.1_Missense_Mutation_p.L56F|HJURP_uc010zne.1_Missense_Mutation_p.L56F	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	63					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		CCCAAATTCTCAATCCTGAAG	0.383000													4	142					0	0	0.009096	0	0
PAK7	57144	broad.mit.edu	37	20	9546721	9546721	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr20:9546721G>A	uc002wnl.2	-	6	1846	c.1301C>T	c.(1300-1302)GCG>GTG	p.A434V	PAK7_uc002wnk.2_Missense_Mutation_p.A434V|PAK7_uc002wnj.2_Missense_Mutation_p.A434V|PAK7_uc010gby.1_Missense_Mutation_p.A434V	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	434	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CTGCAGGGCCGCCCGAAACTG	0.632000													10	283					0	0	0.006214	0	0
RIN2	54453	broad.mit.edu	37	20	19937318	19937318	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr20:19937318G>A	uc002wro.1	+	3	254	c.218G>A	c.(217-219)CGG>CAG	p.R73Q	RIN2_uc010gcu.1_Missense_Mutation_p.R73Q|RIN2_uc010gcv.1_5'UTR	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	73					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						ACCTGTGCCCGGGACTCAGGC	0.582000													4	98					0	0	0.000602	0	0
C21orf58	54058	broad.mit.edu	37	21	47735390	47735390	+	Missense_Mutation	SNP	G	A	A	rs140707382		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr21:47735390G>A	uc002zjf.2	-	5	1576	c.442C>T	c.(442-444)CGG>TGG	p.R148W	C21orf58_uc002ziz.2_Missense_Mutation_p.R65W|C21orf58_uc002zja.2_5'UTR|C21orf58_uc011afw.1_Missense_Mutation_p.R65W|C21orf58_uc002zjc.2_5'UTR|C21orf58_uc011afx.1_5'UTR|C21orf58_uc010gqj.1_RNA|C21orf58_uc002zjg.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	148										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		GGGCCTACCCGGAGTCTCTGC	0.582000													4	162					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	22	18844745	18844745	+	RNA	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr22:18844745C>T	uc002zoe.2	+	4		c.1999C>T			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		GTTCCCACACCTCACTTTTCA	0.572000													12	56					0	0	0.013537	0	0
LOC96610	96610	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr22:23006960C>G	uc011aim.1	+	119		c.7563C>G								Parts of antibodies, mostly variable regions.												0						GGGCTCTGCTCCTCCTCACCC	0.627000													5	49					0	0	0.000602	0	0
TRNT1	51095	broad.mit.edu	37	3	3182233	3182233	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:3182233G>C	uc003bpp.3	+	4	484	c.382G>C	c.(382-384)GAT>CAT	p.D128H	TRNT1_uc010hbv.2_Missense_Mutation_p.D128H|TRNT1_uc003bpm.2_RNA	NM_182916	NP_886552	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	128					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding				0				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		ACTACGGATTGATGTCACCAC	0.353000													8	273					0	0	0.003080	0	0
LMCD1	29995	broad.mit.edu	37	3	8607273	8607273	+	Silent	SNP	A	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:8607273A>C	uc003bqq.2	+	5	993	c.879A>C	c.(877-879)GCA>GCC	p.A293A	LMCD1_uc011atd.1_Silent_p.A220A|LMCD1_uc011ate.1_Silent_p.A181A	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	293	LIM zinc-binding 1.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AGGATGGTGCACCCTGGTGCG	0.632000													11	75					0	0	0.006320	0	0
ZNF860	344787	broad.mit.edu	37	3	32032244	32032244	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:32032244G>A	uc011axg.1	+	2	2222	c.1673G>A	c.(1672-1674)AGA>AAA	p.R558K		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	558	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACACATAAGAGAATTCATACT	0.388000													4	143					0	0	0.009096	0	0
UQCRC1	7384	broad.mit.edu	37	3	48641020	48641020	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:48641020C>T	uc003cub.1	-	6	728	c.683G>A	c.(682-684)CGA>CAA	p.R228Q	UQCRC1_uc003cua.1_Missense_Mutation_p.R113Q|UQCRC1_uc003cuc.1_Missense_Mutation_p.R228Q|UQCRC1_uc003cud.1_Missense_Mutation_p.R228Q	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	228					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	CAGCACCATTCGAGGGGCCTT	0.547000													5	106					0	0	0.000602	0	0
SYNPR	132204	broad.mit.edu	37	3	63466589	63466589	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:63466589G>A	uc003dlq.2	+	2	475	c.106G>A	c.(106-108)GAA>AAA	p.E36K	SYNPR_uc003dlp.2_Missense_Mutation_p.E56K|SYNPR_uc011bfk.1_Intron|SYNPR_uc011bfl.1_RNA|SYNPR_uc010hnt.2_Missense_Mutation_p.E45K|SYNPR_uc011bfm.1_RNA	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	36	MARVEL.|Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		CAACAAGACAGAAAGTAACCT	0.473000													11	597					0	0	0.010729	0	0
GOLGB1	2804	broad.mit.edu	37	3	121415295	121415295	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:121415295C>G	uc003eei.3	-	13	4186	c.4060G>C	c.(4060-4062)GAG>CAG	p.E1354Q	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1359Q|GOLGB1_uc003eej.3_Missense_Mutation_p.E1320Q|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1240Q|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1318Q	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1354	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTAGACTCTCGATTTCTAAA	0.388000													9	735					0	0	0.004482	0	0
CHRD	8646	broad.mit.edu	37	3	184102459	184102459	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:184102459T>G	uc003fov.2	+	13	1821	c.1575T>G	c.(1573-1575)TGT>TGG	p.C525W	CHRD_uc003fow.2_Missense_Mutation_p.C155W|CHRD_uc003fox.2_Missense_Mutation_p.C525W|CHRD_uc003foy.2_Missense_Mutation_p.C155W|CHRD_uc010hyc.2_Missense_Mutation_p.C115W|CHRD_uc011brr.1_Missense_Mutation_p.C155W	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	525					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCCCTACTGTGGGCATAGCG	0.602000													9	171					0	0	0.001855	0	0
CLDN16	10686	broad.mit.edu	37	3	190122569	190122569	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:190122569G>C	uc003fsi.2	+	3	514	c.446G>C	c.(445-447)CGA>CCA	p.R149P	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	149	Extracellular (Potential).		R -> L (in HOMG3).		calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		GTGGTAACTCGAGCGTTGATG	0.448000													5	347					0	0	0.001168	0	0
MUC4	4585	broad.mit.edu	37	3	195508133	195508133	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:195508133G>A	uc011bto.1	-	3	10394	c.9934C>T	c.(9934-9936)CCT>TCT	p.P3312S	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_5'Flank|MUC4_uc011btg.1_5'Flank|MUC4_uc011bth.1_5'Flank|MUC4_uc011bti.1_5'Flank|MUC4_uc011btj.1_5'Flank|MUC4_uc011btk.1_5'Flank|MUC4_uc011btl.1_5'Flank|MUC4_uc011btm.1_5'Flank|MUC4_uc011btn.1_5'Flank|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACAGGAACAGGGGTGGCGTGA	0.592000													3	6					0	0	0.004672	0	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr4:140811099C>T	uc003ihz.1	-	2	2243	c.1491G>A	c.(1489-1491)CAG>CAA	p.Q497Q	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	497	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.279000													5	181					0	0	0.001168	0	0
TRIO	7204	broad.mit.edu	37	5	14504590	14504590	+	Missense_Mutation	SNP	C	T	T	rs56400458		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr5:14504590C>T	uc003jff.2	+	55	8506	c.8500C>T	c.(8500-8502)CGC>TGC	p.R2834C	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2834	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GTTGATGAAGCGCGACCAGGT	0.527000													20	725					0	0	0.008871	0	0
CDH18	1016	broad.mit.edu	37	5	19473661	19473661	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr5:19473661C>T	uc003jgc.2	-	12	2424	c.2047G>A	c.(2047-2049)GAG>AAG	p.E683K	CDH18_uc003jgd.2_Missense_Mutation_p.E683K|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	683	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTGAGCTCCTCAGCAGCAGAA	0.507000													11	459					0	0	0.002450	0	0
LMBRD2	92255	broad.mit.edu	37	5	36105233	36105233	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr5:36105233G>T	uc003jkb.1	-	17	2379	c.1964C>A	c.(1963-1965)GCA>GAA	p.A655E	uc003jka.1_5'Flank	NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	655	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAAAGGTTCTGCATCTTGGAG	0.423000													20	534					8.00594e-06	8.34422e-06	0.007413	1	0
OXCT1	5019	broad.mit.edu	37	5	41807486	41807486	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr5:41807486G>A	uc003jmn.2	-	8	1118	c.787C>T	c.(787-789)CAG>TAG	p.Q263*		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	263					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	ACATAAATCTGAGGAATATGG	0.348000													8	417					0	0	0.004482	0	0
ACSL6	23305	broad.mit.edu	37	5	131298258	131298258	+	Silent	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr5:131298258C>T	uc010jdo.1	-	18	1835	c.1752G>A	c.(1750-1752)GCG>GCA	p.A584A	ACSL6_uc003kvv.1_RNA|ACSL6_uc003kvx.1_Silent_p.A609A|ACSL6_uc003kvy.1_Silent_p.A609A|ACSL6_uc003kwb.2_Silent_p.A574A|ACSL6_uc003kvz.1_Silent_p.A509A|ACSL6_uc003kwa.1_Silent_p.A595A|ACSL6_uc003kvw.1_Silent_p.A230A|ACSL6_uc010jdn.1_Silent_p.A599A	NM_015256	NP_056071	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	584	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATAGATTTGCGCCACAGGTT	0.448000													10	180					0	0	0.010729	0	0
F13A1	2162	broad.mit.edu	37	6	6248563	6248563	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr6:6248563G>A	uc003mwv.2	-	6	903	c.780C>T	c.(778-780)AGC>AGT	p.S260S	F13A1_uc011dib.1_Silent_p.S197S	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	260					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ACCCCACACGGCTGACTTTGA	0.453000													4	228					0	0	0.009096	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333333	33333333	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr6:33333333G>A	uc003shx.2	-	1	807	c.673C>T	c.(673-675)CCT>TCT	p.P225S		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						AGTTAGACAGGAGGCAGCAGC	0.577000													3	52					0	0	0.000602	0	0
LYPLA2P1	653639	broad.mit.edu	37	6	33333342	33333342	+	Silent	SNP	G	A	A	rs140475230	by1000genomes	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr6:33333342G>A	uc003shx.2	-	1	798	c.664C>T	c.(664-666)CTG>TTG	p.L222L		NR_001444				SubName: Full=Lysophospholipase II; Flags: Fragment;												0						GGAGGCAGCAGCTTCTCAAGA	0.562000													3	61					0	0	0.000602	0	0
PIM1	5292	broad.mit.edu	37	6	37139190	37139190	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr6:37139190T>G	uc003onk.2	+	4	960	c.530T>G	c.(529-531)CTC>CGC	p.L177R	PIM1_uc011dtw.1_5'Flank	NM_002648	NP_002639	P11309	PIM1_HUMAN	non-specific serine/threonine protein kinase	268	Protein kinase.				cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CTTATCGACCTCAATCGCGGC	0.642000			T	BCL6	NHL								11	174					0	0	0.013537	0	0
MCM3	4172	broad.mit.edu	37	6	52144376	52144376	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr6:52144376C>T	uc003pan.1	-	5	663	c.553G>A	c.(553-555)GAG>AAG	p.E185K	MCM3_uc011dwu.1_Missense_Mutation_p.E139K	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	185					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					TATTCTGTCTCAAGGGGATTG	0.527000													12	458					0	0	0.001855	0	0
RADIL	55698	broad.mit.edu	37	7	4862126	4862126	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:4862126G>A	uc003snj.1	-	6	1687	c.1514C>T	c.(1513-1515)CCC>CTC	p.P505L	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Missense_Mutation_p.P10L|RADIL_uc011jwc.1_Missense_Mutation_p.P265L|RADIL_uc011jwd.1_Intron	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	505	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GAAAAGAATGGGCTGCAAGTC	0.542000													4	216					0	0	0.009096	0	0
DNAH11	8701	broad.mit.edu	37	7	21781758	21781758	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:21781758C>G	uc003svc.2	+	50	8180	c.8149C>G	c.(8149-8151)CTG>GTG	p.L2717V		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2717	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CATCTTTAATCTGAGAGATTT	0.353000									Kartagener_syndrome				8	324					0	0	0.004482	0	0
ZNF138	7697	broad.mit.edu	37	7	64276007	64276007	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:64276007G>C	uc011kdp.1	+	3	360	c.184G>C	c.(184-186)GAG>CAG	p.E62Q	ZNF138_uc003ttg.2_Missense_Mutation_p.E5Q|ZNF138_uc011kdq.1_Intron|ZNF138_uc003tth.2_Intron|ZNF138_uc010kzs.2_Intron	NM_001160183	NP_001153655	B4DFX2	B4DFX2_HUMAN	zinc finger protein 138 isoform 2	62					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0		Lung NSC(55;0.0795)|all_lung(88;0.18)				GAAGAGACATGAGATGGTGGT	0.413000													6	353					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	7	64528850	64528850	+	RNA	SNP	T	G	G	rs2949472	by1000genomes	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:64528850T>G	uc003ttt.1	+	5		c.644T>G			uc010kzt.1_RNA|uc003ttu.1_5'Flank					Homo sapiens cDNA clone IMAGE:4215179, partial cds.																		GAATTCTGGCTTTTTTTACAA	0.284000													4	83					0	0	0.001168	0	0
UPK3B	80761	broad.mit.edu	37	7	76141063	76141063	+	Missense_Mutation	SNP	C	G	G	rs144200247		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:76141063C>G	uc003ufq.2	+	2	715	c.490C>G	c.(490-492)CTG>GTG	p.L164V	UPK3B_uc003ufo.2_Missense_Mutation_p.L109V|UPK3B_uc010ldk.1_Missense_Mutation_p.L109V	NM_030570	NP_085047	Q9BT76	UPK3B_HUMAN	uroplakin 3B isoform a	164	Lumenal (Potential).				negative regulation of gene expression	integral to membrane|plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(862;0.204)				GACGCTGCCCCTGTCTCCGGA	0.697000													4	78					0	0	0.000602	0	0
PCLO	27445	broad.mit.edu	37	7	82579081	82579081	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:82579081G>C	uc003uhx.2	-	6	11112	c.10823C>G	c.(10822-10824)TCC>TGC	p.S3608C	PCLO_uc003uhv.2_Missense_Mutation_p.S3608C|PCLO_uc010lec.2_Missense_Mutation_p.S573C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3539					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTGTACTGTGGAATCTGCCCG	0.488000													9	428					0	0	0.006214	0	0
PCLO	27445	broad.mit.edu	37	7	82579163	82579163	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:82579163G>C	uc003uhx.2	-	6	11030	c.10741C>G	c.(10741-10743)CTG>GTG	p.L3581V	PCLO_uc003uhv.2_Missense_Mutation_p.L3581V|PCLO_uc010lec.2_Missense_Mutation_p.L546V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3512					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTGGCACTCAGATATTGAGGA	0.443000													18	344					0	0	0.010504	0	0
PCLO	27445	broad.mit.edu	37	7	82580303	82580303	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:82580303G>C	uc003uhx.2	-	6	9890	c.9601C>G	c.(9601-9603)CTT>GTT	p.L3201V	PCLO_uc003uhv.2_Missense_Mutation_p.L3201V|PCLO_uc010lec.2_Missense_Mutation_p.L166V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3132					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACAATTAAAAGAGCACTTTCA	0.453000													9	247					0	0	0.006214	0	0
ASZ1	136991	broad.mit.edu	37	7	117003669	117003669	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:117003669A>G	uc003vjb.2	-	13	1472	c.1409T>C	c.(1408-1410)CTA>CCA	p.L470P	ASZ1_uc011kno.1_Missense_Mutation_p.L461P|ASZ1_uc011knp.1_Missense_Mutation_p.L262P	NM_130768	NP_570124	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper	470					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			CTGGAAAGTTAGCTTGCAAAT	0.313000													6	281					0	0	0.003080	0	0
OR6V1	346517	broad.mit.edu	37	7	142749918	142749918	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr7:142749918C>T	uc011ksv.1	+	1	481	c.481C>T	c.(481-483)CGA>TGA	p.R161*		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGTCCTCTCCCGAGCTCATCT	0.562000													11	515					0	0	0.010729	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585461	70585461	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr8:70585461G>A	uc003xyl.2	-	10	2897	c.2190C>T	c.(2188-2190)AAC>AAT	p.N730N	SLCO5A1_uc010lzb.2_Silent_p.N675N|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	730	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ACGACGTCACGTTGTACTCCC	0.453000													21	717					0	0	0.002780	0	0
ADCY8	114	broad.mit.edu	37	8	131949412	131949412	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr8:131949412T>C	uc003ytd.3	-	5	1644	c.1388A>G	c.(1387-1389)GAC>GGC	p.D463G	ADCY8_uc010mds.2_Missense_Mutation_p.D463G	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	463	Cytoplasmic (Potential).	Magnesium 2 (By similarity).|Magnesium 1 (By similarity).			activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTAGTAGCAGTCCCCCAGGAT	0.493000										HNSCC(32;0.087)			6	217					0	0	0.001168	0	0
KIAA0020	9933	broad.mit.edu	37	9	2831330	2831330	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:2831330G>A	uc003zhp.1	-	6	627	c.531C>T	c.(529-531)CAC>CAT	p.H177H	KIAA0020_uc010mhc.1_Silent_p.H176H|KIAA0020_uc003zhq.1_Silent_p.H177H	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	177	Pumilio 1.|PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		GAGTTGAATCGTGTGCAAATG	0.343000													14	295					0	0	0.001855	0	0
MLLT3	4300	broad.mit.edu	37	9	20414295	20414295	+	Silent	SNP	G	A	A	rs62637688		TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:20414295G>A	uc003zoe.2	-	5	808	c.549C>T	c.(547-549)AGC>AGT	p.S183S	MLLT3_uc011lne.1_Silent_p.S151S|MLLT3_uc011lnf.1_Silent_p.S180S|MLLT3_uc003zof.2_5'UTR	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	183	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.144000			T	MLL	ALL								6	367					0	0	0.004482	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:20414373G>A	uc003zoe.2	-	5	730	c.471C>T	c.(469-471)AGC>AGT	p.S157S	MLLT3_uc011lne.1_Silent_p.S125S|MLLT3_uc011lnf.1_Silent_p.S154S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Intron	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.134000			T	MLL	ALL								6	183					0	0	0.001168	0	0
TRPM3	80036	broad.mit.edu	37	9	73151305	73151305	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:73151305G>A	uc004aid.2	-	25	4932	c.4688C>T	c.(4687-4689)GCG>GTG	p.A1563V	TRPM3_uc004ahu.2_Missense_Mutation_p.A1405V|TRPM3_uc004ahv.2_Missense_Mutation_p.A1365V|TRPM3_uc004ahw.2_Missense_Mutation_p.A1435V|TRPM3_uc004ahx.2_Missense_Mutation_p.A1422V|TRPM3_uc004ahy.2_Missense_Mutation_p.A1425V|TRPM3_uc004ahz.2_Missense_Mutation_p.A1412V|TRPM3_uc004aia.2_Missense_Mutation_p.A1410V|TRPM3_uc004aib.2_Missense_Mutation_p.A1400V|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1588	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						AGCTCTGTCCGCAATTGCTTG	0.493000													6	437					0	0	0.001168	0	0
TNC	3371	broad.mit.edu	37	9	117846596	117846596	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:117846596T>C	uc004bjj.3	-	4	2385	c.2023A>G	c.(2023-2025)ACG>GCG	p.T675A	TNC_uc010mvf.2_Missense_Mutation_p.T675A	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	675	Fibronectin type-III 1.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						ATGGTGGACGTCTGGTCCCCA	0.572000													6	202					0	0	0.001168	0	0
PAPPA	5069	broad.mit.edu	37	9	118950123	118950123	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:118950123C>G	uc004bjn.2	+	2	1487	c.1106C>G	c.(1105-1107)ACG>AGG	p.T369R	PAPPA_uc011lxp.1_Missense_Mutation_p.T162R|PAPPA_uc011lxq.1_Missense_Mutation_p.T162R	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	369	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						AAGAACCCGACGGTGACGCGC	0.567000													6	160					0	0	0.001984	0	0
CEP110	11064	broad.mit.edu	37	9	123937354	123937354	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:123937354A>G	uc004bkx.1	+	41	6837	c.6806A>G	c.(6805-6807)CAG>CGG	p.Q2269R	CEP110_uc004blb.1_Missense_Mutation_p.Q938R|CEP110_uc010mvp.1_Missense_Mutation_p.Q219R	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	2269	Sufficient for interaction with HOOK2.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						GGAAAGCGGCAGACAGAGGGC	0.453000													13	591					0	0	0.001855	0	0
OR1N2	138882	broad.mit.edu	37	9	125315794	125315794	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr9:125315794G>A	uc011lyx.1	+	1	346	c.346G>A	c.(346-348)GCA>ACA	p.A116T		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	116	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TGGGTGTCTTGCACAGCTATA	0.488000													29	826					0	0	0.010818	0	0
DMD	1756	broad.mit.edu	37	X	32382821	32382821	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:32382821G>T	uc004dda.1	-	36	5276	c.5032C>A	c.(5032-5034)CAG>AAG	p.Q1678K	DMD_uc004dcw.2_Missense_Mutation_p.Q334K|DMD_uc004dcx.2_Missense_Mutation_p.Q337K|DMD_uc004dcz.2_Missense_Mutation_p.Q1555K|DMD_uc004dcy.1_Missense_Mutation_p.Q1674K|DMD_uc004ddb.1_Missense_Mutation_p.Q1670K|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1678	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATGTGTTTCTGGTATTCCTTA	0.343000													8	380					5.18039e-06	5.43757e-06	0.003080	1	0
WAS	7454	broad.mit.edu	37	X	48542293	48542293	+	Silent	SNP	G	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:48542293G>A	uc004dkm.3	+	1	108	c.51G>A	c.(49-51)GCG>GCA	p.A17A		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	17					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				GAGCACCAGCGGTTCAGCAGA	0.607000			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				6	317					0	0	0.001168	0	0
ALAS2	212	broad.mit.edu	37	X	55051204	55051204	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:55051204A>G	uc004dua.3	-	3	389	c.251T>C	c.(250-252)ATT>ACT	p.I84T	ALAS2_uc004dub.3_Missense_Mutation_p.I108T|ALAS2_uc004dud.3_Missense_Mutation_p.I84T	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	84					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	CTTCTGCACAATCTTGCTCTT	0.493000													15	450					0	0	0.003163	0	0
KIF4A	24137	broad.mit.edu	37	X	69622526	69622526	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:69622526T>A	uc004dyg.2	+	23	2727	c.2600T>A	c.(2599-2601)CTG>CAG	p.L867Q	KIF4A_uc010nkw.2_Missense_Mutation_p.L867Q	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	867	Potential.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						AAGTGTGCCCTGAAATATTTG	0.448000													3	119					0	0	0.000602	0	0
PHKA1	5255	broad.mit.edu	37	X	71915684	71915684	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:71915684C>T	uc004eax.3	-	4	629	c.328G>A	c.(328-330)GAT>AAT	p.D110N	PHKA1_uc004eay.3_Missense_Mutation_p.D110N|PHKA1_uc011mqi.1_Missense_Mutation_p.D110N	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	110					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					TGGAGGCTATCCTTAGTACTC	0.413000													12	487					0	0	0.001855	0	0
PCDH19	57526	broad.mit.edu	37	X	99661960	99661960	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:99661960T>A	uc010nmz.2	-	1	3312	c.1636A>T	c.(1636-1638)AAC>TAC	p.N546Y	PCDH19_uc004efw.3_Missense_Mutation_p.N546Y|PCDH19_uc004efx.3_Missense_Mutation_p.N546Y	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	546	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						ACCGTAGCGTTGCTTTGCAGT	0.592000													17	592					0	0	0.007413	0	0
NOX1	27035	broad.mit.edu	37	X	100118551	100118551	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:100118551A>G	uc004egj.2	-	3	381	c.175T>C	c.(175-177)TGC>CGC	p.C59R	uc010nnf.2_Intron|NOX1_uc004egl.3_Missense_Mutation_p.C59R|NOX1_uc010nne.2_Intron	NM_007052	NP_008983	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1 isoform long	59	Ferric oxidoreductase.|Helical; (Potential).				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			ovary(1)	1						AAATTCAAGCAGAGAGCAGAC	0.522000													3	134					0	0	0.004672	0	0
ODZ1	10178	broad.mit.edu	37	X	123538943	123538943	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:123538943C>T	uc004euj.2	-	26	5372	c.5308G>A	c.(5308-5310)GAG>AAG	p.E1770K	ODZ1_uc011muj.1_Missense_Mutation_p.E1776K|ODZ1_uc010nqy.2_Missense_Mutation_p.E1777K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1770	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGCCGCCACTCGATGAGGTTT	0.512000													15	607					0	0	0.004990	0	0
MIR510	574515	broad.mit.edu	37	X	146353864	146353864	+	RNA	SNP	C	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:146353864C>G	hsa-mir-510|MI0003197	-			c.63C>G																				0						TGTTACTCCACTCTTAGAGGT	0.413000													4	183					0	0	0.009096	0	0
TMEM48	55706	broad.mit.edu	37	1	54298190	54298192	+	In_Frame_Del	DEL	TTA	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr1:54298190_54298192delTTA	uc001cvs.2	-	3	492_494	c.251_253delTAA	c.(250-255)ATAAGT>AGT	p.I84del	TMEM48_uc010onu.1_In_Frame_Del_p.I84del|TMEM48_uc001cvt.2_5'UTR|TMEM48_uc009vzk.2_RNA|TMEM48_uc010onv.1_5'UTR	NM_018087	NP_060557	Q9BTX1	NDC1_HUMAN	transmembrane protein 48	84	Helical; Name=2; (Potential).				mRNA transport|nuclear pore complex assembly|nuclear pore distribution|protein transport|transmembrane transport	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore			ovary(1)|pancreas(1)	2						TTGAAAATACTTATTATTATTAT	0.305													9	276	---	---	---	---					
ARFGAP2	84364	broad.mit.edu	37	11	47196853	47196853	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr11:47196853delA	uc001ndt.2	-	4	291	c.276delT	c.(274-276)TTTfs	p.F92fs	ARFGAP2_uc010rha.1_5'Flank|ARFGAP2_uc010rhb.1_Frame_Shift_Del_p.F92fs|ARFGAP2_uc001ndu.2_Intron|ARFGAP2_uc010rhc.1_Intron|ARFGAP2_uc010rhd.1_Frame_Shift_Del_p.F92fs|ARFGAP2_uc001ndv.1_3'UTR	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	92	Arf-GAP.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						CATGTTGGCGAAAAAAAGCCG	0.537													7	499	---	---	---	---					
NUFIP2	57532	broad.mit.edu	37	17	27620990	27620992	+	In_Frame_Del	DEL	GCT	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:27620990_27620992delGCT	uc002hdy.3	-	1	175_177	c.86_88delAGC	c.(85-90)CAGCCG>CCG	p.Q29del	NUFIP2_uc002hdx.3_In_Frame_Del_p.Q29del	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	29	His-rich.					nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			tggtggtgcggctgctgctgctg	0.251													9	300	---	---	---	---					
TMEM92	162461	broad.mit.edu	37	17	48356292	48356292	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:48356292delC	uc002iqn.1	+	4	331	c.301delC	c.(301-303)CCCfs	p.P101fs		NM_153229	NP_694961	Q6UXU6	TMM92_HUMAN	transmembrane protein 92 precursor	101	Pro-rich.|Cytoplasmic (Potential).					integral to membrane					0						CCTGGAACTGCCCTCCATCAT	0.627													10	252	---	---	---	---					
ERN1	2081	broad.mit.edu	37	17	62207360	62207362	+	In_Frame_Del	DEL	CAG	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr17:62207360_62207362delCAG	uc002jdz.2	-	1	141_143	c.28_30delCTG	c.(28-30)CTGdel	p.L10del		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	10					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						gcagcagcgtcagcagcagcagc	0.695													2	4	---	---	---	---					
CHRNG	1146	broad.mit.edu	37	2	233409154	233409154	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr2:233409154delG	uc002vsx.1	+	10	1134	c.1113delG	c.(1111-1113)CAGfs	p.Q371fs	CHRNG_uc010fye.1_Frame_Shift_Del_p.Q319fs	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	371	Cytoplasmic (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		AGGACACCCAGTCCCGGCTAC	0.642													19	488	---	---	---	---					
MUC4	4585	broad.mit.edu	37	3	195512373	195512374	+	In_Frame_Ins	INS	-	GAT	GAT	rs140335395	by1000genomes	TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chr3:195512373_195512374insGAT	uc011bto.1	-	2	6537_6538	c.6077_6078insATC	c.(6076-6078)TCC>TCATCC	p.2026_2026S>SS	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	798	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCACCAGTGGATGCTGAGGA	0.579													4	6	---	---	---	---					
EMD	2010	broad.mit.edu	37	X	153608098	153608099	+	Frame_Shift_Ins	INS	-	G	G			TCGA-FQ-6554-01A-11D-1795-08	TCGA-FQ-6554-11A-01D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	4fa4cdc2-c0eb-4401-9a95-1221b8f94042	a3203a77-16b7-4f19-9e54-0d8929f1b50d	g.chrX:153608098_153608099insG	uc004fkl.2	+	2	379_380	c.131_132insG	c.(130-132)CAGfs	p.Q44fs		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	44	LEM.				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACGAGACCCAGAGGCGGCGGC	0.683													7	308	---	---	---	---					
