Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R1	80835	broad.mit.edu	37	1	6639255	6639255	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:6639255C>T	uc001ant.2	+	6	2137	c.2137C>T	c.(2137-2139)CCC>TCC	p.P713S	TAS1R1_uc001anu.2_Missense_Mutation_p.P459S|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	713	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CCAGCGCTTCCCCCATCTGGT	0.567													21	221					0	0	0.592651	0	0
TAS1R1	80835	broad.mit.edu	37	1	6639422	6639422	+	Silent	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:6639422C>T	uc001ant.2	+	6	2304	c.2304C>T	c.(2302-2304)TTC>TTT	p.F768F	TAS1R1_uc001anu.2_Silent_p.F514F|TAS1R1_uc001anv.2_Missense_Mutation_p.S300L|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	768	Helical; Name=6; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		GCCTGCTCTTCAACTTCGTGT	0.577													17	268					0	0	0.557998	0	0
MST1P2	11209	broad.mit.edu	37	1	16976896	16976896	+	RNA	SNP	A	G	G	rs149376405	by1000genomes	TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:16976896A>G	uc010och.1	+	14		c.2617A>G			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						aaacagtaataaagaagagaa	0													4	48					0	0	0.150653	0	0
MST1P9	11223	broad.mit.edu	37	1	17086003	17086003	+	Silent	SNP	G	C	C	rs3982176		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:17086003G>C	uc010ock.1	-	7	894	c.894C>G	c.(892-894)GGC>GGG	p.G298G	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CCGCCCCCCCGCCCACCTCAC	0.657													3	29					0	0	0.184627	0	0
NBPF3	84224	broad.mit.edu	37	1	21806606	21806606	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:21806606T>G	uc001ber.2	+	11	1621	c.1271T>G	c.(1270-1272)TTT>TGT	p.F424C	NBPF3_uc001bes.2_Missense_Mutation_p.F368C|NBPF3_uc009vqb.2_Missense_Mutation_p.F412C|NBPF3_uc010odm.1_Missense_Mutation_p.F354C	NM_032264	NP_115640	Q9H094	NBPF3_HUMAN	neuroblastoma breakpoint family, member 3	424	NBPF 3.					cytoplasm				upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(284;2.16e-05)|Lung NSC(340;2.19e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|OV - Ovarian serous cystadenocarcinoma(117;7.53e-27)|COAD - Colon adenocarcinoma(152;1.18e-05)|GBM - Glioblastoma multiforme(114;3.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000143)|STAD - Stomach adenocarcinoma(196;0.00306)|KIRC - Kidney renal clear cell carcinoma(1967;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTGGATAGATTTTATTCAACT	0.468													3	47					0	0	0.115264	0	0
GBP6	163351	broad.mit.edu	37	1	89847396	89847396	+	Missense_Mutation	SNP	G	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:89847396G>T	uc001dnf.2	+	7	1289	c.1015G>T	c.(1015-1017)GCC>TCC	p.A339S	GBP6_uc010ost.1_Missense_Mutation_p.A209S	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	339							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		CCAGCAGATGGCCCAGCGAGT	0.587													7	294					0.00448238	0.00464439	0.307466	1	0
BNIPL	149428	broad.mit.edu	37	1	151015566	151015566	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:151015566G>A	uc001ewl.2	+	5	741	c.568G>A	c.(568-570)GTA>ATA	p.V190I	BNIPL_uc009wmi.2_Missense_Mutation_p.V108I|BNIPL_uc009wmj.2_RNA	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	190					apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGAGCAGCGCGTAGACATGAC	0.493													7	268					0	0	0.248553	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:155887393T>G	uc001fmi.1	-	11	1361	c.1337A>C	c.(1336-1338)CAG>CCG	p.Q446P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q446P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q303P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	446	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.448													14	125					0	0	0.539581	0	0
OLFML2B	25903	broad.mit.edu	37	1	161954024	161954024	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:161954024C>T	uc001gbu.2	-	8	2118	c.1694G>A	c.(1693-1695)GGC>GAC	p.G565D	OLFML2B_uc001gbt.2_Missense_Mutation_p.G48D|OLFML2B_uc010pkq.1_Missense_Mutation_p.G566D	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	565	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GTGGCCTGTGCCGATCCAGCT	0.592													5	284					0	0	0.184627	0	0
ASTN1	460	broad.mit.edu	37	1	177001910	177001910	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:177001910G>A	uc001glc.2	-	3	759	c.547C>T	c.(547-549)CGC>TGC	p.R183C	ASTN1_uc001glb.1_Missense_Mutation_p.R183C|ASTN1_uc001gld.1_Missense_Mutation_p.R183C|ASTN1_uc009wwx.1_Missense_Mutation_p.R183C|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	183					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						ACCCGGCGGCGTTTGCACCAG	0.602													7	246					0	0	0.307466	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200827083	200827083	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:200827083G>A	uc001gvl.2	+	18	4636	c.4366G>A	c.(4366-4368)GCT>ACT	p.A1456T	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.A1445T|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.A1429T	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1456	CKK.					cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCACATACCCGCTAAAACTTT	0.373													6	601					0	0	0.278610	0	0
ITIH5	80760	broad.mit.edu	37	10	7679259	7679259	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr10:7679259G>A	uc001ijq.2	-	5	663	c.584C>T	c.(583-585)GCG>GTG	p.A195V	ITIH5_uc001ijr.1_Missense_Mutation_p.A195V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	195					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TGCGATGCCCGCGCTCTCCAG	0.657													13	394					0	0	0.457914	0	0
TLL2	7093	broad.mit.edu	37	10	98144477	98144477	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr10:98144477G>A	uc001kml.1	-	16	2287	c.2061C>T	c.(2059-2061)GAC>GAT	p.D687D		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	687	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCAGCTTGGCGTCGGGGGACA	0.617													6	476					0	0	0.217242	0	0
TRUB1	142940	broad.mit.edu	37	10	116698112	116698112	+	Missense_Mutation	SNP	A	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr10:116698112A>C	uc001lcd.2	+	1	161	c.100A>C	c.(100-102)ACC>CCC	p.T34P	TRUB1_uc010qsl.1_Intron	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	34					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		AATGGCTGCGACCCCGTCAGC	0.637													10	32					0	0	0.760397	0	0
OR4A16	81327	broad.mit.edu	37	11	55111199	55111199	+	Missense_Mutation	SNP	T	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr11:55111199T>A	uc010rie.1	+	1	523	c.523T>A	c.(523-525)TCT>ACT	p.S175T		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TATTGACCACTCTGTCTGTGA	0.443													15	615					0	0	0.479597	0	0
UBXN1	51035	broad.mit.edu	37	11	62445435	62445435	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr11:62445435T>C	uc001nul.1	-	5	578	c.446A>G	c.(445-447)GAG>GGG	p.E149G	UBXN1_uc001nuj.2_Missense_Mutation_p.E149G|UBXN1_uc001num.1_Missense_Mutation_p.E149G|UBXN1_uc001nuk.2_Missense_Mutation_p.E114G|UBXN1_uc010rme.1_Missense_Mutation_p.E149G|UBXN1_uc010rmf.1_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	149	Potential.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						CCTCCGCCTCTCCTCAGCAGC	0.557													6	219					0	0	0.217242	0	0
SHANK2	22941	broad.mit.edu	37	11	70331622	70331622	+	Silent	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr11:70331622C>T	uc001oqc.2	-	21	4854	c.4776G>A	c.(4774-4776)GGG>GGA	p.G1592G	SHANK2_uc010rqn.1_Silent_p.G1004G|SHANK2_uc001opz.2_Silent_p.G997G|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1213					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCTTGGCCATCCCAGGCTGGG	0.433													18	373					0	0	0.520397	0	0
TECTA	7007	broad.mit.edu	37	11	120980206	120980206	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr11:120980206C>G	uc010rzo.1	+	3	485	c.485C>G	c.(484-486)CCT>CGT	p.P162R		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	162	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGCACCACACCTGTAATAATT	0.423													8	341					0	0	0.307466	0	0
NEDD1	121441	broad.mit.edu	37	12	97330427	97330427	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr12:97330427C>T	uc001teu.3	+	8	1097	c.758C>T	c.(757-759)GCG>GTG	p.A253V	NEDD1_uc001tev.3_Missense_Mutation_p.A253V|NEDD1_uc010svc.1_Missense_Mutation_p.A164V|NEDD1_uc001tew.2_Missense_Mutation_p.A260V|NEDD1_uc001tex.2_Missense_Mutation_p.A164V	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	253	WD 7.				cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						CCTCTAACTGCGGTAGATTTC	0.388													5	250					0	0	0.217242	0	0
C14orf115	55237	broad.mit.edu	37	14	74824923	74824923	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr14:74824923G>A	uc001xpw.3	+	2	1628	c.1437G>A	c.(1435-1437)GCG>GCA	p.A479A		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	479					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AGAGTGAGGCGGAAGAGGGGG	0.652													12	311					0	0	0.387290	0	0
NUBP2	10101	broad.mit.edu	37	16	1837999	1837999	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr16:1837999C>T	uc002cmw.3	+	5	636	c.547C>T	c.(547-549)CGG>TGG	p.R183W	NUBP2_uc002cmx.3_Missense_Mutation_p.R42W|NUBP2_uc010brx.2_Missense_Mutation_p.R123W	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	183						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						GACGGGCTTGCGGGTGATGGG	0.687													5	354					0	0	0.184627	0	0
RSL1D1	26156	broad.mit.edu	37	16	11933660	11933660	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr16:11933660T>G	uc002dbp.1	-	8	1111	c.1038A>C	c.(1036-1038)AAA>AAC	p.K346N	RSL1D1_uc010buv.1_Missense_Mutation_p.K345N|RSL1D1_uc010uyw.1_Missense_Mutation_p.K126N|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	346					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TGCCACGTTTTTTCTTCCCAT	0.428													34	797					0	0	0.779181	0	0
SCNN1B	6338	broad.mit.edu	37	16	23364206	23364206	+	Silent	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr16:23364206C>T	uc002dln.2	+	3	572	c.396C>T	c.(394-396)AGC>AGT	p.S132S		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	132	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CTGAGCTAAGCCATGCCAATG	0.537													10	434					0	0	0.335167	0	0
NCOR1	9611	broad.mit.edu	37	17	16024504	16024504	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr17:16024504G>A	uc002gpo.2	-	16	1954	c.1714C>T	c.(1714-1716)CGA>TGA	p.R572*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.R572*|NCOR1_uc002gpp.1_Nonsense_Mutation_p.R463*|NCOR1_uc002gpr.2_Nonsense_Mutation_p.R463*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	572					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCAGTCTTTCGCCCCCGGGGT	0.542													21	692					0	0	0.654019	0	0
MC2R	4158	broad.mit.edu	37	18	13884663	13884663	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr18:13884663G>A	uc002ksp.1	-	2	1032	c.855C>T	c.(853-855)GAC>GAT	p.D285D		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	285	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	TTTTGAATGCGTCCCTGAGCT	0.488													14	487					0	0	0.479597	0	0
CATSPERG	57828	broad.mit.edu	37	19	38851156	38851156	+	Missense_Mutation	SNP	C	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr19:38851156C>G	uc002oih.3	+	15	1723	c.1636C>G	c.(1636-1638)CGG>GGG	p.R546G	CATSPERG_uc002oig.3_Missense_Mutation_p.R506G|CATSPERG_uc002oif.3_Missense_Mutation_p.R186G|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	546	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GGGCAGCTACCGGGTCTACCA	0.577													12	289					0	0	0.387290	0	0
ZNF616	90317	broad.mit.edu	37	19	52620223	52620223	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr19:52620223G>C	uc002pym.2	-	4	477	c.194C>G	c.(193-195)ACA>AGA	p.T65R	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	65	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CCTTTCTCCTGTATTACTGTT	0.333													16	413					0	0	0.479597	0	0
ZNF534	147658	broad.mit.edu	37	19	52942423	52942423	+	Missense_Mutation	SNP	T	A	A	rs112113280		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr19:52942423T>A	uc002pzk.2	+	4	1810	c.1749T>A	c.(1747-1749)AAT>AAA	p.N583K	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.N570K	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	583	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GACATAGGAATATTCATACTG	0.438													4	61					0	0	0.150653	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331182	55331182	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr19:55331182C>A	uc002qhk.3	+	4	433	c.370C>A	c.(370-372)CCT>ACT	p.P124T	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.P66T|KIR3DL1_uc010esf.2_Missense_Mutation_p.P29T|KIR3DL1_uc010yfo.1_Missense_Mutation_p.P66T|KIR3DL1_uc002qhl.3_Missense_Mutation_p.P124T	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	124	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CCACAGAAAACCTTCCCTCCT	0.493													13	348					5.01169e-05	5.25617e-05	0.520397	1	0
SMYD1	150572	broad.mit.edu	37	2	88387407	88387407	+	Missense_Mutation	SNP	T	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:88387407T>G	uc002ssr.2	+	3	343	c.341T>G	c.(340-342)GTG>GGG	p.V114G	SMYD1_uc002ssq.1_Intron	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						ATGTGGCGGGTGGAGAGAGAA	0.542													7	32					0	0	0.864702	0	0
Unknown	0	broad.mit.edu	37	2	89345703	89345703	+	RNA	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:89345703G>A	uc010ytr.1	-	63		c.5635C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GACTTGCCCGGCAAGTGATGG	0.507													6	551					0	0	0.248553	0	0
Unknown	0	broad.mit.edu	37	2	96521777	96521777	+	Missense_Mutation	SNP	T	C	C	rs77768218		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:96521777T>C	uc002suz.1	-	31	2790	c.1313A>G	c.(1312-1314)CAT>CGT	p.H438R						SubName: Full=Putative uncharacterized protein ENSP00000312008; Flags: Fragment;																		AAGGTCTTCATGCTTTCTTTT	0.383													5	157					0	0	0.278610	0	0
THSD7B	80731	broad.mit.edu	37	2	137988686	137988686	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:137988686G>A	uc002tva.1	+	7	1703	c.1703G>A	c.(1702-1704)CGA>CAA	p.R568Q	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.R458Q	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		ATTCCCTGCCGAATGGACTGT	0.488													10	252					0	0	0.361761	0	0
NEB	4703	broad.mit.edu	37	2	152352826	152352826	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:152352826C>A	uc010fnx.2	-	140	19073	c.18882G>T	c.(18880-18882)ATG>ATT	p.M6294I	NEB_uc002txr.2_Missense_Mutation_p.M2686I|RIF1_uc002txp.2_Intron|NEB_uc010zbz.1_Missense_Mutation_p.M94I|NEB_uc002txq.2_Missense_Mutation_p.M173I|NEB_uc010zca.1_Missense_Mutation_p.M125I|NEB_uc010zcb.1_Missense_Mutation_p.M94I	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	6294	Nebulin 173.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGACTCGCTCCATCTCGGGAG	0.363													5	114					3.59834e-05	3.82046e-05	0.217242	1	0
NEB	4703	broad.mit.edu	37	2	152410411	152410411	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:152410411G>A	uc010fnx.2	-	98	14645	c.14454C>T	c.(14452-14454)CAC>CAT	p.H4818H	NEB_uc002txr.2_Silent_p.H1241H	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4818	Nebulin 131.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AAATCCATTCGTGGAGGCGCA	0.488													13	432					0	0	0.411799	0	0
CCDC150	284992	broad.mit.edu	37	2	197583282	197583282	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr2:197583282G>A	uc002utp.1	+	18	2057	c.1922G>A	c.(1921-1923)CGT>CAT	p.R641H	CCDC150_uc010zgs.1_Missense_Mutation_p.R288H|CCDC150_uc010zgt.1_Missense_Mutation_p.R58H|CCDC150_uc002utq.1_5'Flank|CCDC150_uc002utr.1_5'Flank	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	641	Potential.										0						GTGAAGTGTCGTAATGCGGCC	0.428													5	168					0	0	0.184627	0	0
PRIC285	85441	broad.mit.edu	37	20	62200278	62200278	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr20:62200278G>A	uc002yfm.2	-	6	2055	c.1163C>T	c.(1162-1164)CCG>CTG	p.P388L	PRIC285_uc002yfl.1_5'Flank	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	388					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CAGTGCTCCCGGAGGCGCGAA	0.677													14	251					0	0	0.479597	0	0
DIP2A	23181	broad.mit.edu	37	21	47924304	47924304	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr21:47924304C>T	uc002zjo.2	+	6	869	c.686C>T	c.(685-687)ACG>ATG	p.T229M	DIP2A_uc011afy.1_Missense_Mutation_p.T165M|DIP2A_uc011afz.1_Missense_Mutation_p.T229M|DIP2A_uc002zjl.2_Missense_Mutation_p.T229M|DIP2A_uc002zjm.2_Missense_Mutation_p.T229M|DIP2A_uc010gql.2_Intron|DIP2A_uc002zjn.2_Missense_Mutation_p.T229M|DIP2A_uc002zjp.1_Translation_Start_Site	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	229					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		GATGTCACCACGGGCCTCGTG	0.502													8	97					0	0	0.307466	0	0
TTLL12	23170	broad.mit.edu	37	22	43575988	43575988	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr22:43575988G>A	uc003bdq.2	-	4	597	c.565C>T	c.(565-567)CCG>TCG	p.P189S	TTLL12_uc003bdr.1_Missense_Mutation_p.P189S	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	189					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				TACCACACCGGCATCTTCTCC	0.612													5	393					0	0	0.248553	0	0
ATRIP	84126	broad.mit.edu	37	3	48495778	48495778	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr3:48495778C>T	uc003ctf.1	+	4	663	c.631C>T	c.(631-633)CGA>TGA	p.R211*	ATRIP_uc011bbj.1_Nonsense_Mutation_p.R84*|ATRIP_uc003ctg.1_Nonsense_Mutation_p.R211*	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	211	Potential.				DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GACCAGTGAACGAGCAAATAA	0.413								Other_conserved_DNA_damage_response_genes					16	359					0	0	0.479597	0	0
SDHAP2	727956	broad.mit.edu	37	3	195410627	195410627	+	Missense_Mutation	SNP	A	G	G	rs6583272	by1000genomes	TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr3:195410627A>G	uc003fuw.2	+	13	1718	c.524A>G	c.(523-525)CAG>CGG	p.Q175R	SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						CCTCAGGTGCAGATTGATGAG	0.473													6	59					0	0	0.387290	0	0
SDHAP2	727956	broad.mit.edu	37	3	195410640	195410640	+	Silent	SNP	T	C	C	rs6583273	by1000genomes	TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr3:195410640T>C	uc003fuw.2	+	13	1731	c.537T>C	c.(535-537)TAT>TAC	p.Y179Y	SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						TTGATGAGTATGATCACTCCA	0.468													3	66					0	0	0.278610	0	0
TEC	7006	broad.mit.edu	37	4	48140955	48140955	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr4:48140955G>A	uc003gxz.2	-	16	1711	c.1620C>T	c.(1618-1620)AGC>AGT	p.S540S		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	540	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						TGCTGAAGCGGCTGTAATTAA	0.448													4	242					0	0	0.150653	0	0
BTC	685	broad.mit.edu	37	4	75673355	75673355	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr4:75673355G>A	uc003hig.2	-	5	780	c.433C>T	c.(433-435)CTT>TTT	p.L145F		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	145	Cytoplasmic (Potential).				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			CGTTTCCGAAGAGGGCTTGGA	0.353													6	272					0	0	0.217242	0	0
MMRN1	22915	broad.mit.edu	37	4	90874335	90874335	+	Silent	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr4:90874335C>T	uc003hst.2	+	8	3524	c.3453C>T	c.(3451-3453)ATC>ATT	p.I1151I	MMRN1_uc010iku.2_Silent_p.I454I|MMRN1_uc011cds.1_Silent_p.I893I	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1151	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AGTACACCATCGAGTCATTTA	0.333													7	282					0	0	0.248553	0	0
IRX1	79192	broad.mit.edu	37	5	3599747	3599747	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr5:3599747G>A	uc003jde.2	+	2	737	c.685G>A	c.(685-687)GAC>AAC	p.D229N		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGAAAGCATCGACATTGACAA	0.642													9	198					0	0	0.335167	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54639161	54639161	+	Missense_Mutation	SNP	C	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr5:54639161C>A	uc003jpy.3	+	8	1050	c.784C>A	c.(784-786)CGT>AGT	p.R262S	SKIV2L2_uc011cqi.1_Missense_Mutation_p.R161S	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	262	Helicase ATP-binding.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTTTTCAGAACGTGGTGTAGT	0.338													7	352					2.0095e-06	2.16021e-06	0.248553	1	0
PDE8B	8622	broad.mit.edu	37	5	76624825	76624825	+	Missense_Mutation	SNP	C	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr5:76624825C>T	uc003kfa.2	+	4	638	c.593C>T	c.(592-594)TCG>TTG	p.S198L	PDE8B_uc003kfb.2_Missense_Mutation_p.S178L|PDE8B_uc003kfc.2_Missense_Mutation_p.S198L|PDE8B_uc003kfd.2_Missense_Mutation_p.S198L|PDE8B_uc003kfe.2_Missense_Mutation_p.S198L	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	198					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CATTGCAGGTCGATCCGGGCC	0.473													8	231					0	0	0.278610	0	0
RPS10	6204	broad.mit.edu	37	6	34386195	34386195	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr6:34386195G>A	uc003ojm.2	-	5	627	c.407C>T	c.(406-408)GCC>GTC	p.A136V	RPS10_uc003ojn.2_Missense_Mutation_p.A136V	NM_001014	NP_001005	P46783	RS10_HUMAN	ribosomal protein S10	136					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding				0						TTTCTTGTCGGCACCAGCTAG	0.438													4	183					0	0	0.150653	0	0
PRSS35	167681	broad.mit.edu	37	6	84233939	84233939	+	Missense_Mutation	SNP	C	T	T	rs141429310	byFrequency	TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr6:84233939C>T	uc003pjz.2	+	2	942	c.779C>T	c.(778-780)CCG>CTG	p.P260L	PRSS35_uc010kbm.2_Missense_Mutation_p.P260L	NM_153362	NP_699193	Q8N3Z0	PRS35_HUMAN	protease, serine, 35 precursor	260	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		ACCCACATTCCGAAGGGCTGG	0.537													7	219					0	0	0.248553	0	0
C6orf174	387104	broad.mit.edu	37	6	127837119	127837119	+	Missense_Mutation	SNP	G	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr6:127837119G>C	uc003qbd.2	-	2	1506	c.641C>G	c.(640-642)GCC>GGC	p.A214G		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	214	Gly-rich.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		AGAAGGGGAGGCCCCCTCCCC	0.741													12	51					0	0	0.639603	0	0
C6orf174	387104	broad.mit.edu	37	6	127837125	127837125	+	Missense_Mutation	SNP	T	C	C	rs75863720		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr6:127837125T>C	uc003qbd.2	-	2	1500	c.635A>G	c.(634-636)GAG>GGG	p.E212G		NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	212	Gly-rich.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GGAGGCCCCCTCCCCGCCGCT	0.741													16	30					0	0	0.827153	0	0
PKD1L1	168507	broad.mit.edu	37	7	47879176	47879176	+	Silent	SNP	G	A	A	rs138494625		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr7:47879176G>A	uc003tny.1	-	36	5637	c.5637C>T	c.(5635-5637)CAC>CAT	p.H1879H		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1879	PLAT.|Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCACCATCACGTGGCTGATGA	0.657													4	46					0	0	0.150653	0	0
POM121	9883	broad.mit.edu	37	7	72413896	72413896	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr7:72413896A>G	uc003twk.2	+	11	3364	c.3364A>G	c.(3364-3366)ACC>GCC	p.T1122A	POM121_uc003twj.2_Missense_Mutation_p.T857A|POM121_uc010lam.1_Missense_Mutation_p.T857A	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1122	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AGGCTCCAGCACCACCACCGG	0.637													4	135					0	0	0.184627	0	0
DPY19L2P2	349152	broad.mit.edu	37	7	102825947	102825947	+	Missense_Mutation	SNP	A	G	G			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr7:102825947A>G	uc003vbh.3	-	20	3239	c.1048T>C	c.(1048-1050)TGT>CGT	p.C350R	DPY19L2P2_uc003vbg.3_RNA|DPY19L2P2_uc010lit.2_RNA	NR_003561				RecName: Full=Protein dpy-19 homolog 2-like 2; AltName: Full=Dpy-19-like protein 2 pseudogene 2;												0						ACAGCTTGACACTTGCCATTG	0.373													8	410					0	0	0.335167	0	0
ST7	7982	broad.mit.edu	37	7	116869933	116869933	+	Missense_Mutation	SNP	A	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr7:116869933A>C	uc011knn.1	+	14	1465	c.1460A>C	c.(1459-1461)CAC>CCC	p.H487P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TCCTCCACTCACCTCACCCGC	0.522													30	189					0	0	0.870114	0	0
MLL3	58508	broad.mit.edu	37	7	151945524	151945524	+	Silent	SNP	T	C	C	rs80268686		TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr7:151945524T>C	uc003wla.2	-	14	2214	c.1995A>G	c.(1993-1995)GAA>GAG	p.E665E		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	665	Potential.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACTGCAGTTGTTCTTGCTGCA	0.408			N		medulloblastoma								4	306					0	0	0.150653	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr9:20414379G>A	uc003zoe.2	-	5	724	c.465C>T	c.(463-465)AGC>AGT	p.S155S	MLLT3_uc011lne.1_Silent_p.S123S|MLLT3_uc011lnf.1_Silent_p.S152S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Silent_p.S123S	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.149			T	MLL	ALL								6	225					0	0	0.278610	0	0
Unknown	0	broad.mit.edu	37	9	68413570	68413570	+	RNA	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr9:68413570G>A	uc004aex.2	+	1		c.125G>A								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		CCCCAGTGGCGCCGGATCTAG	0.562													3	19					0	0	0.184627	0	0
SLC35D2	11046	broad.mit.edu	37	9	99113436	99113436	+	Missense_Mutation	SNP	T	C	C			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr9:99113436T>C	uc004awc.2	-	6	513	c.437A>G	c.(436-438)AAC>AGC	p.N146S	SLC35D2_uc010msd.2_RNA|SLC35D2_uc010mse.2_Intron|SLC35D2_uc010msf.2_Missense_Mutation_p.N146S|SLC35D2_uc004awd.2_Intron|SLC35D2_uc004awe.2_3'UTR	NM_007001	NP_008932	Q76EJ3	S35D2_HUMAN	solute carrier family 35, member D2	146	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity				0		Acute lymphoblastic leukemia(62;0.0167)				GAGGATGATGTTGAGTGAATA	0.353													5	210					0	0	0.184627	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070116	141070116	+	Missense_Mutation	SNP	G	A	A	rs142836124	by1000genomes	TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr9:141070116G>A	uc004com.2	+	3	275	c.14G>A	c.(13-15)CGC>CAC	p.R5H	TUBBP5_uc010ncq.2_Missense_Mutation_p.R119H					RecName: Full=Putative tubulin beta-4q chain;												0						GACTCTGTGCGCTCGGGGCCC	0.687													11	297					0	0	0.387290	0	0
DDX26B	203522	broad.mit.edu	37	X	134681136	134681136	+	Missense_Mutation	SNP	G	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chrX:134681136G>A	uc004eyw.3	+	6	1051	c.688G>A	c.(688-690)GGT>AGT	p.G230S		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	230											0	Acute lymphoblastic leukemia(192;6.56e-05)					AGTTCAGAGTGGTGTAGTTAT	0.338													35	451					0	0	0.804634	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:22838561_22838563delAAG	uc001bft.2	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)AAGdel	p.K803del	ZBTB40_uc001bfu.2_In_Frame_Del_p.K803del|ZBTB40_uc009vqi.1_In_Frame_Del_p.K691del|ZBTB40_uc001bfv.1_In_Frame_Del_p.K432del	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													7	355	---	---	---	---					
GLMN	11146	broad.mit.edu	37	1	92737019	92737020	+	Splice_Site	INS	-	A	A			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr1:92737019_92737020insA	uc001dor.2	-	8	1038	c.923_splice	c.e8+1	p.S308_splice	GLMN_uc009wdg.2_Splice_Site|GLMN_uc001dos.2_Splice_Site_p.S308_splice	NM_053274	NP_444504	Q92990	GLMN_HUMAN	glomulin						muscle cell differentiation|negative regulation of T cell proliferation|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of phosphorylation|regulation of gene expression, epigenetic|vasculogenesis	intracellular	hepatocyte growth factor receptor binding			skin(1)	1		all_lung(203;0.00827)|Lung NSC(277;0.0295)		all cancers(265;0.00702)|GBM - Glioblastoma multiforme(16;0.0381)|Epithelial(280;0.0989)		CACTAACTCTTACCTTAAGACC	0.312									Multiple_Glomus_Tumors_(of_the_Skin)_Familial				10	509	---	---	---	---					
ACVR1B	91	broad.mit.edu	37	12	52387799	52387802	+	Frame_Shift_Del	DEL	GAGT	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr12:52387799_52387802delGAGT	uc001rzn.2	+	9	1465_1468	c.1423_1426delGAGT	c.(1423-1428)GAGTGTfs	p.E475fs	ACVR1B_uc010snn.1_Frame_Shift_Del_p.E516fs	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	475_476	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	GATGATGCGAGAGTGTTGGTATGC	0.608													7	352	---	---	---	---					
ZFC3H1	196441	broad.mit.edu	37	12	72057256	72057258	+	In_Frame_Del	DEL	GCT	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr12:72057256_72057258delGCT	uc001swo.2	-	1	492_494	c.133_135delAGC	c.(133-135)AGCdel	p.S45del	ZFC3H1_uc010sts.1_In_Frame_Del_p.S45del|ZFC3H1_uc001swp.2_In_Frame_Del_p.S45del|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	45	Ser-rich.				RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GCCCGCCGCCGCTGCTGCTGCTG	0.631											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	577	---	---	---	---					
AKAP6	9472	broad.mit.edu	37	14	33293966	33293969	+	Frame_Shift_Del	DEL	ATAT	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr14:33293966_33293969delATAT	uc001wrq.2	+	13	7117_7120	c.6947_6950delATAT	c.(6946-6951)AATATGfs	p.N2316fs		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2316_2317					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CGACATAGAAATATGCATAGGTAG	0.402													13	427	---	---	---	---					
RALGAPA1	253959	broad.mit.edu	37	14	36194270	36194270	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr14:36194270delT	uc001wti.2	-	14	2217	c.1826delA	c.(1825-1827)AATfs	p.N609fs	RALGAPA1_uc001wtj.2_Frame_Shift_Del_p.N609fs|RALGAPA1_uc010tpv.1_Frame_Shift_Del_p.N609fs|RALGAPA1_uc010tpw.1_Frame_Shift_Del_p.N609fs|RALGAPA1_uc001wtk.1_Frame_Shift_Del_p.N460fs	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	609					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CAAGGTCATATTTTTTTTCCC	0.363													7	337	---	---	---	---					
ADAM6	8755	broad.mit.edu	37	14	106993939	106993941	+	RNA	DEL	TAC	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr14:106993939_106993941delTAC	uc010tyt.1	-	187		c.8506_8508delGTA								Parts of antibodies, mostly variable regions.												0						TAGTATATGGTACTACTACTACT	0.502													7	967	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7576916	7576917	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr17:7576916_7576917insT	uc002gim.2	-	9	1123_1124	c.929_930insA	c.(928-930)AACfs	p.N310fs	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Frame_Shift_Ins_p.N310fs|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_Frame_Shift_Ins_p.N178fs|TP53_uc010cng.1_Frame_Shift_Ins_p.N178fs|TP53_uc002gii.1_Frame_Shift_Ins_p.N178fs|TP53_uc010cnh.1_Frame_Shift_Ins_p.N310fs|TP53_uc010cni.1_Frame_Shift_Ins_p.N310fs|TP53_uc002gij.2_Frame_Shift_Ins_p.N310fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	310	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		N -> T (in sporadic cancers; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.N310fs*27(2)|p.?(2)|p.N310T(2)|p.A307fs*34(1)|p.N310L(1)|p.L308fs*15(1)|p.L308fs*31(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGCTGGTGTTGTTGGGCAGTGC	0.480		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	325	---	---	---	---					
SPAG9	9043	broad.mit.edu	37	17	49077041	49077041	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr17:49077041delT	uc002itc.2	-	14	1854	c.1645delA	c.(1645-1647)AGGfs	p.R549fs	SPAG9_uc002itb.2_Frame_Shift_Del_p.R535fs|SPAG9_uc002itd.2_Frame_Shift_Del_p.R535fs|SPAG9_uc002itf.2_Frame_Shift_Del_p.R370fs|SPAG9_uc002ita.2_Frame_Shift_Del_p.R392fs|SPAG9_uc002ite.2_Frame_Shift_Del_p.R379fs	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	549					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			ATGCTTGACCTTTTTTTTTCC	0.323													12	224	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr3:5248941delT	uc003bqi.2	+	7	1453	c.1321delT	c.(1321-1323)TTTfs	p.F441fs	EDEM1_uc011asz.1_Frame_Shift_Del_p.F219fs|EDEM1_uc003bqh.2_Frame_Shift_Del_p.F441fs	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	441	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													8	693	---	---	---	---					
GUF1	60558	broad.mit.edu	37	4	44700615	44700615	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr4:44700615delA	uc003gww.3	+	17	2134	c.1927delA	c.(1927-1929)AAAfs	p.K643fs	GUF1_uc011bza.1_Frame_Shift_Del_p.K50fs	NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	643					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						AGCAGAAGGGAAAAAAAAGCT	0.328													7	295	---	---	---	---					
PKD2	5311	broad.mit.edu	37	4	88986559	88986559	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr4:88986559delA	uc003hre.2	+	11	2218	c.2152delA	c.(2152-2154)AAAfs	p.K718fs	PKD2_uc011cdf.1_Frame_Shift_Del_p.K136fs|PKD2_uc011cdg.1_Frame_Shift_Del_p.K44fs|PKD2_uc011cdh.1_5'UTR	NM_000297	NP_000288	Q13563	PKD2_HUMAN	polycystin 2	718	EF-hand domain.|Cytoplasmic (Potential).					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			skin(1)	1		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACTAAAACTGAAAAAAAATAC	0.348													7	598	---	---	---	---					
HEATR7B2	133558	broad.mit.edu	37	5	41004528	41004528	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr5:41004528delT	uc003jmj.3	-	37	4604	c.4114delA	c.(4114-4116)ATCfs	p.I1372fs	HEATR7B2_uc003jmi.3_Frame_Shift_Del_p.I927fs	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1372	HEAT 15.						binding	p.I1372T(1)		ovary(6)|central_nervous_system(2)	8						AGCTCCAGGATTTTTTTTAGA	0.438													7	623	---	---	---	---					
TSC1	7248	broad.mit.edu	37	9	135771988	135771990	+	In_Frame_Del	DEL	GCT	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chr9:135771988_135771990delGCT	uc004cca.2	-	23	3361_3363	c.3127_3129delAGC	c.(3127-3129)AGCdel	p.S1043del	TSC1_uc004ccb.3_In_Frame_Del_p.S1042del|TSC1_uc011mcq.1_In_Frame_Del_p.S992del|TSC1_uc011mcr.1_In_Frame_Del_p.235_236AA>A	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	1043	Poly-Ser.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.S1043N(1)|p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TAGAAAGCTCgctgctgctgctg	0.571			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				7	207	---	---	---	---					
SPANXN3	139067	broad.mit.edu	37	X	142605149	142605149	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FQ-6555-01A-11D-1795-08	TCGA-FQ-6555-11A-02D-1795-08									Somatic	Phase_I	Capture				Illumina GAIIx	32e14d29-f17e-4256-9666-ab6281bb6586	db326b1c-af00-43e7-9f9e-f8aea221b5d0	g.chrX:142605149delT	uc004fbw.2	-	1	159	c.71delA	c.(70-72)AATfs	p.N24fs		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	24										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TACCTCATCATTTTTTTTGTT	0.239													9	423	---	---	---	---					
