Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17086000	17086001	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:17086000_17086001CC>TT	uc010ock.1	-	7	896_897	c.896_897GG>AA	c.(895-897)GGG>GAA	p.G299E	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						CGCCCGCCCCCCCGCCCACCTC	0.653000													6	5					0	0	6.4e-05	0	0
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800272	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:28800272T>C	uc001bpw.2	+	7	1312	c.1030T>C	c.(1030-1032)TCC>CCC	p.S344P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.S328P|PHACTR4_uc001bpy.2_Missense_Mutation_p.S354P	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACT	0.512000													4	139					0	0	1.23904e-05	0	0
HMGB4	127540	broad.mit.edu	37	1	34330054	34330054	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:34330054C>G	uc001bxp.2	+	2	2005	c.262C>G	c.(262-264)CGG>GGG	p.R88G	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Missense_Mutation_p.R14G	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	88						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				ACGGAGAAAGCGGGATCCCCA	0.517000													23	62					0	0	0.000117367	0	0
TEKT2	27285	broad.mit.edu	37	1	36550643	36550643	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:36550643G>A	uc001bzr.2	+	2	248	c.121G>A	c.(121-123)GAG>AAG	p.E41K	TEKT2_uc001bzs.2_5'UTR	NM_014466	NP_055281	Q9UIF3	TEKT2_HUMAN	tektin 2	41					cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GATCCGCCAGGAGGCCCGGGT	0.617000													13	20					0	0	0.000308642	0	0
GBP1	2633	broad.mit.edu	37	1	89523792	89523792	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:89523792G>A	uc001dmx.2	-	6	977	c.757C>T	c.(757-759)CTA>TTA	p.L253L		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	253					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCATCTTGTAGTTTCTCGAGC	0.448000													91	107					0	0	0.000147903	0	0
ABCD3	5825	broad.mit.edu	37	1	94964564	94964564	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:94964564C>T	uc001dqn.3	+	19	1696	c.1594C>T	c.(1594-1596)CAG>TAG	p.Q532*	ABCD3_uc010oto.1_Nonsense_Mutation_p.Q556*|ABCD3_uc010otp.1_Nonsense_Mutation_p.Q459*|ABCD3_uc009wdr.2_Nonsense_Mutation_p.Q422*|ABCD3_uc001dqo.3_Nonsense_Mutation_p.Q220*	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	532	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		ACGAGAAGATCAGAAAAGGAA	0.348000													76	90					0	0	0.000147903	0	0
NOTCH2	4853	broad.mit.edu	37	1	120497802	120497803	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:120497802_120497803CC>AA	uc001eik.2	-	13	2335_2336	c.2079_2080GG>TT	c.(2077-2082)AAGGGT>AATTGT	p.693_694KG>NC	NOTCH2_uc001eil.2_Missense_Mutation_p.693_694KG>NC|NOTCH2_uc001eim.3_Missense_Mutation_p.610_611KG>NC	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	693_694	EGF-like 18; calcium-binding (Potential).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATGTTGCACCCTTGCGACAGG	0.510000			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				15	538					0	0	6.4e-05	0	0
HRNR	388697	broad.mit.edu	37	1	152191323	152191323	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:152191323G>C	uc001ezt.1	-	3	2858	c.2782C>G	c.(2782-2784)CAG>GAG	p.Q928E		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	928	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGAAGACTGGCCTGAGCCA	0.607000													7	262					0	0	0.000295444	0	0
FLG2	388698	broad.mit.edu	37	1	152324257	152324257	+	Missense_Mutation	SNP	G	C	C	rs144200854	by1000genomes	TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:152324257G>C	uc001ezw.3	-	3	6078	c.6005C>G	c.(6004-6006)GCA>GGA	p.A2002G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2002	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGGTATCTGCTGTTTGTCC	0.517000													4	291					0	0	0.000157383	0	0
FLG2	388698	broad.mit.edu	37	1	152324262	152324262	+	Silent	SNP	T	C	C	rs144862791	by1000genomes	TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:152324262T>C	uc001ezw.3	-	3	6073	c.6000A>G	c.(5998-6000)CAA>CAG	p.Q2000Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2000	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TATCTGCTGTTTGTCCATGAG	0.512000													4	287					0	0	0.000157383	0	0
HCN3	57657	broad.mit.edu	37	1	155255641	155255641	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:155255641G>C	uc001fjz.1	+	6	1371	c.1363G>C	c.(1363-1365)GTG>CTG	p.V455L	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_Missense_Mutation_p.V150L	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	455	Cytoplasmic (Potential).|cAMP.					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGGGGATCTCGTGGTGCGTGA	0.652000													73	46					0	0	0.000147903	0	0
KCNK1	3775	broad.mit.edu	37	1	233802615	233802615	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:233802615G>A	uc010pxo.1	+	2	798	c.630G>A	c.(628-630)TGG>TGA	p.W210*	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	210						voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	AGGATGACTGGAACTTCCTGG	0.507000													71	45					0	0	0.000147903	0	0
RYR2	6262	broad.mit.edu	37	1	237947253	237947253	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:237947253G>A	uc001hyl.1	+	90	12361	c.12241G>A	c.(12241-12243)GAA>AAA	p.E4081K	RYR2_uc010pya.1_Missense_Mutation_p.E496K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4081					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCTCGACTACGAAGAGTTCGT	0.517000													7	26					0	0	2.17888e-05	0	0
OR2W5	441932	broad.mit.edu	37	1	247654438	247654438	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr1:247654438G>A	uc001icz.1	+	1	9	c.9G>A	c.(7-9)AAG>AAA	p.K3K		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTATGGGAAAGGACAATGCCA	0.453000													63	47					0	0	0.000147903	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													5	35					0	0	1.23904e-05	0	0
Unknown	0	broad.mit.edu	37	10	49218498	49218498	+	Silent	SNP	A	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr10:49218498A>G	uc001jgd.2	-	8	1800	c.1641T>C	c.(1639-1641)TCT>TCC	p.S547S	uc001jge.1_5'Flank					RecName: Full=Arf-GAP, GTPase, ANK repeat and PH domain-containing protein 11; AltName: Full=Centaurin-gamma-like protein KIAA1975;																		GCTGGCCCAGAGACAGCTCAG	0.582000													3	3					0	0	3.59834e-05	0	0
PGBD3	267004	broad.mit.edu	37	10	50724287	50724287	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr10:50724287G>A	uc001jht.2	-	2	1129	c.874C>T	c.(874-876)CGG>TGG	p.R292W	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.R760W|PGBD3_uc001jhu.2_Missense_Mutation_p.R760W	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	292										pancreas(1)|breast(1)|skin(1)	3						TAGCCAAACCGAATGGGCTTT	0.408000													19	2					0	0	0.000229342	0	0
PLCE1	51196	broad.mit.edu	37	10	96073071	96073071	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr10:96073071C>T	uc001kjk.2	+	28	6698	c.6064C>T	c.(6064-6066)CCA>TCA	p.P2022S	PLCE1_uc010qnx.1_Missense_Mutation_p.P2006S|PLCE1_uc001kjm.2_Missense_Mutation_p.P1714S|PLCE1_uc001kjp.2_Missense_Mutation_p.P380S	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	2022	Ras-associating 1.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GCATGGGGTCCCAGGGCCAGA	0.478000													55	6					0	0	0.000147903	0	0
CC2D2B	387707	broad.mit.edu	37	10	97775979	97775979	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr10:97775979G>A	uc001kll.2	+	6	629	c.430G>A	c.(430-432)GGA>AGA	p.G144R	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Missense_Mutation_p.G144R	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	144										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TTTAGCTATCGGAAATAAGGA	0.418000													24	4					0	0	5.49717e-05	0	0
CTSD	1509	broad.mit.edu	37	11	1774847	1774847	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:1774847G>A	uc001luc.1	-	9	1258	c.1125C>T	c.(1123-1125)ATC>ATT	p.I375I	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	375					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGGTGGCGGGATGTCCATGC	0.662000													30	22					0	0	0.000339439	0	0
KCNQ1	3784	broad.mit.edu	37	11	2869161	2869161	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:2869161C>T	uc001lwn.2	+	16	2067	c.1959C>T	c.(1957-1959)TTC>TTT	p.F653F	KCNQ1_uc001lwo.2_Silent_p.F526F	NM_000218	NP_000209	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like	653	Cytoplasmic (Potential).				blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			ovary(1)	1		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	CTGAGCTCTTCCTGCCCAGCA	0.736000													39	49					0	0	0.000106405	0	0
OR51A2	401667	broad.mit.edu	37	11	4976682	4976682	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:4976682G>A	uc010qyt.1	-	1	262	c.262C>T	c.(262-264)CTG>TTG	p.L88L		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCATTGAACAGGAAGATGCTT	0.468000													47	4					0	0	0.000147903	0	0
ABCC8	6833	broad.mit.edu	37	11	17470088	17470088	+	Missense_Mutation	SNP	G	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:17470088G>T	uc001mnc.2	-	8	1433	c.1307C>A	c.(1306-1308)CCA>CAA	p.P436Q	ABCC8_uc010rcy.1_Missense_Mutation_p.P435Q	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	436	Helical; Name=8; (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCAGAGGTTTGGGCACAAGAA	0.532000													10	329					2.17888e-05	0.000525896	2.17888e-05	1	0
OR8I2	120586	broad.mit.edu	37	11	55860936	55860936	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:55860936G>A	uc010rix.1	+	1	153	c.153G>A	c.(151-153)ATG>ATA	p.M51I		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					TAATCAGAATGGATTCTCAGC	0.368000													69	87					0	0	0.000147903	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64594849	64594850	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr11:64594849_64594850GG>AA	uc001obs.3	-	33	4171_4172	c.4171_4172CC>TT	c.(4171-4173)CCG>TTG	p.P1391L		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1391					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GGTGAGGTCCGGGATGTCGAAC	0.634000													48	56					0	0	6.4e-05	0	0
CLEC4C	170482	broad.mit.edu	37	12	7882210	7882210	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:7882210C>T	uc001qtg.1	-	6	798	c.624G>A	c.(622-624)ATG>ATA	p.M208I	CLEC4C_uc001qth.1_Missense_Mutation_p.M208I|CLEC4C_uc001qti.1_Missense_Mutation_p.M177I	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	208	Extracellular (Potential).				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		AGATCTTCTTCATCTTGCAAA	0.363000													24	33					0	0	7.16444e-05	0	0
PZP	5858	broad.mit.edu	37	12	9322148	9322148	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:9322148G>A	uc001qvl.2	-	16	1908	c.1879C>T	c.(1879-1881)CCT>TCT	p.P627S	PZP_uc009zgl.2_Missense_Mutation_p.P496S|PZP_uc010sgo.1_5'Flank|PZP_uc009zgm.1_5'UTR	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						ACATTGTCAGGAAAATTGGTG	0.418000													18	33					0	0	0.000229342	0	0
LRP6	4040	broad.mit.edu	37	12	12334004	12334005	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:12334004_12334005CG>AT	uc001rah.3	-	6	1487_1488	c.1345_1346CG>AT	c.(1345-1347)CGG>ATG	p.R449M	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.R449M	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	449	Extracellular (Potential).|LDL-receptor class B 7.|Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CACAATAGCCCGGGGTTCCTCT	0.421000													14	346					0	0	6.4e-05	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18800840	18800840	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:18800840G>A	uc001rdt.2	+	32	4332	c.4216G>A	c.(4216-4218)GGA>AGA	p.G1406R	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.G1447R|PIK3C2G_uc010sic.1_Missense_Mutation_p.G1225R	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1406	C2.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AGAGCTCCAAGGACATGTCTT	0.338000													13	12					0	0	0.000308642	0	0
KIF21A	55605	broad.mit.edu	37	12	39760883	39760883	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:39760883G>A	uc001rly.2	-	5	830	c.684C>T	c.(682-684)GCC>GCT	p.A228A	KIF21A_uc001rlx.2_Silent_p.A228A|KIF21A_uc001rlz.2_Silent_p.A228A|KIF21A_uc010skl.1_Silent_p.A228A|KIF21A_uc001rma.1_Silent_p.A236A	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	228	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGGTAAAAATGGCATGTGAAC	0.393000													19	23					0	0	0.000132079	0	0
BAZ2A	11176	broad.mit.edu	37	12	56994245	56994245	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:56994245G>A	uc001slq.1	-	24	4832	c.4638C>T	c.(4636-4638)ACC>ACT	p.T1546T	BAZ2A_uc001slp.1_Silent_p.T1544T|BAZ2A_uc001slo.1_Silent_p.T352T|BAZ2A_uc009zov.1_Silent_p.T512T|BAZ2A_uc009zow.1_Silent_p.T1514T	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1546					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						AGTCTTCACGGGTAGAGTCTG	0.498000													35	48					0	0	0.000191422	0	0
SLC16A7	9194	broad.mit.edu	37	12	60098690	60098690	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:60098690C>T	uc001sqs.2	+	3	407	c.108C>T	c.(106-108)TTC>TTT	p.F36F	SLC16A7_uc001sqt.2_Silent_p.F36F|SLC16A7_uc001squ.2_Silent_p.F36F|SLC16A7_uc009zqi.2_5'UTR|SLC16A7_uc010ssi.1_5'UTR	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	36	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	CCTATGCATTCCCCAAAGCTG	0.448000													31	32					0	0	0.000339439	0	0
TXNRD1	7296	broad.mit.edu	37	12	104714898	104714899	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:104714898_104714899CG>AT	uc010swk.1	+	10	1041_1042	c.1019_1020CG>AT	c.(1018-1020)CCG>CAT	p.P340H	TXNRD1_uc010swl.1_Missense_Mutation_p.P190H|TXNRD1_uc010swm.1_Missense_Mutation_p.P242H|TXNRD1_uc010swn.1_Missense_Mutation_p.P190H|TXNRD1_uc010swo.1_Missense_Mutation_p.P190H|TXNRD1_uc010swp.1_Missense_Mutation_p.P152H|TXNRD1_uc010swq.1_Missense_Mutation_p.P240H|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.P256H	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	340					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						CCTTACTGCCCGGGTAAGACCC	0.371000													8	225					0	0	6.4e-05	0	0
SRRM4	84530	broad.mit.edu	37	12	119568628	119568628	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:119568628G>A	uc001txa.1	+	8	1052	c.760G>A	c.(760-762)GCC>ACC	p.A254T		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	254	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CTACCTGTCAGCCAGGGGTGT	0.607000													4	11					0	0	1.23904e-05	0	0
C12orf43	64897	broad.mit.edu	37	12	121442834	121442834	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:121442834G>A	uc001tzh.1	-	5	447	c.424C>T	c.(424-426)CGC>TGC	p.R142C	C12orf43_uc009zxa.1_Missense_Mutation_p.R173C|C12orf43_uc010szo.1_Missense_Mutation_p.R100C|C12orf43_uc010szp.1_Missense_Mutation_p.R131C|C12orf43_uc001tzi.1_Missense_Mutation_p.R142C	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	142											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CGCTTTCGGCGGGGTTGGGGA	0.413000													131	156					0	0	0.000147903	0	0
CAMKK2	10645	broad.mit.edu	37	12	121691221	121691222	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:121691221_121691222CC>AA	uc001tzu.2	-	10	1085_1086	c.961_962GG>TT	c.(961-963)GGA>TTA	p.G321L	CAMKK2_uc001tzt.2_Missense_Mutation_p.G321L|CAMKK2_uc001tzv.2_Missense_Mutation_p.G321L|CAMKK2_uc001tzw.2_Missense_Mutation_p.G321L|CAMKK2_uc001tzx.2_Missense_Mutation_p.G321L|CAMKK2_uc001tzy.2_Missense_Mutation_p.G321L|CAMKK2_uc001tzz.1_Missense_Mutation_p.G108L|CAMKK2_uc001uaa.1_Missense_Mutation_p.G321L|CAMKK2_uc001uab.2_Missense_Mutation_p.G321L|CAMKK2_uc001uac.2_Missense_Mutation_p.G321L	NM_006549	NP_006540	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase	321	Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			lung(1)|large_intestine(1)|stomach(1)	3	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCCATCTTCTCCGACCAGGAGG	0.559000													12	422					0	0	6.4e-05	0	0
NCOR2	9612	broad.mit.edu	37	12	124911200	124911200	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr12:124911200C>A	uc010tba.1	-	11	1413	c.1296G>T	c.(1294-1296)TGG>TGT	p.W432C	NCOR2_uc010tay.1_Missense_Mutation_p.W432C|NCOR2_uc010taz.1_Missense_Mutation_p.W432C|NCOR2_uc010tbb.1_Missense_Mutation_p.W432C|NCOR2_uc010tbc.1_Missense_Mutation_p.W431C|NCOR2_uc001ugj.1_Missense_Mutation_p.W432C|NCOR2_uc001ugk.1_Missense_Mutation_p.W432C	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	432	SANT 1.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCTGCTCACTCCACATGTTCA	0.597000													19	16					4.35082e-09	1.05637e-07	0.000175454	1	0
SLC46A3	283537	broad.mit.edu	37	13	29278231	29278231	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr13:29278231G>A	uc001usi.2	-	4	2120	c.1150C>T	c.(1150-1152)CTG>TTG	p.L384L	SLC46A3_uc001usg.2_Silent_p.L309L|SLC46A3_uc001usj.2_Silent_p.L384L|SLC46A3_uc001ush.2_Silent_p.L384L	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	384	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		CAAGCAAACAGGGTACCTGTT	0.388000													54	60					0	0	0.000147903	0	0
NEK5	341676	broad.mit.edu	37	13	52678636	52678636	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr13:52678636G>A	uc001vge.2	-	9	747	c.607C>T	c.(607-609)CCT>TCT	p.P203S	NEK5_uc001vgf.2_Missense_Mutation_p.P203S	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	203	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		ATACTTACAGGATGTTTAAGT	0.318000													95	116					0	0	0.000147903	0	0
PCDH20	64881	broad.mit.edu	37	13	61985483	61985483	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr13:61985483C>T	uc001vid.3	-	2	3113	c.2749G>A	c.(2749-2751)GAA>AAA	p.E917K	PCDH20_uc010thj.1_Missense_Mutation_p.E917K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	890	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGATGCTTTTCCCCTTTCCTT	0.418000													18	19					0	0	9.7654e-05	0	0
MYO16	23026	broad.mit.edu	37	13	109707920	109707920	+	Silent	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr13:109707920T>C	uc001vqt.1	+	27	3372	c.3246T>C	c.(3244-3246)CTT>CTC	p.L1082L	MYO16_uc010agk.1_Silent_p.L1104L|MYO16_uc001vqu.1_Silent_p.L882L|MYO16_uc010tjh.1_Silent_p.L594L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1082	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CTGTTCGCCTTTCCTTCTCGG	0.433000													3	146					0	0	0.00024832	0	0
ATP11A	23250	broad.mit.edu	37	13	113514656	113514656	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr13:113514656C>G	uc001vsi.3	+	24	2871	c.2783C>G	c.(2782-2784)CCC>CGC	p.P928R	ATP11A_uc001vsj.3_Missense_Mutation_p.P928R|ATP11A_uc001vsm.1_Missense_Mutation_p.P804R|ATP11A_uc010ago.2_Intron	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	928	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				ACCTCCCTCCCCATCCTCCTG	0.522000													3	111					0	0	6.4e-05	0	0
EDDM3A	10876	broad.mit.edu	37	14	21215867	21215867	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr14:21215867G>A	uc001vyb.2	+	2	195	c.128G>A	c.(127-129)CGA>CAA	p.R43Q	EDDM3A_uc001vyc.2_Missense_Mutation_p.R43Q	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	43					sperm displacement	extracellular space					0						AGTCCAAGTCGAGAATTCAAA	0.373000													41	4					0	0	0.000374591	0	0
Unknown	0	broad.mit.edu	37	15	20488878	20488878	+	RNA	SNP	G	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:20488878G>C	uc001ytf.1	+	2		c.361G>C								full-length cDNA clone CS0DI026YN18 of Placenta Cot 25-normalized of Homo sapiens (human).																		CCGTGCTGTGGACTGCTGGAG	0.433000													6	64					0	0	2.17888e-05	0	0
FBN1	2200	broad.mit.edu	37	15	48780580	48780580	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:48780580C>T	uc001zwx.1	-	26	3521	c.3193G>A	c.(3193-3195)GAA>AAA	p.E1065K		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1065	EGF-like 15; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CAGTTCCTTTCTTCAGAATCA	0.473000													54	64					0	0	0.000147903	0	0
CILP	8483	broad.mit.edu	37	15	65490487	65490487	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:65490487C>T	uc002aon.2	-	9	2318	c.2137G>A	c.(2137-2139)GAT>AAT	p.D713N		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	713					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						AATTTGAAATCACCTTCCTCC	0.493000													50	43					0	0	0.000147903	0	0
LMAN1L	79748	broad.mit.edu	37	15	75111605	75111605	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:75111605C>T	uc002ayt.1	+	6	712	c.710C>T	c.(709-711)ACC>ATC	p.T237I	LMAN1L_uc010bkd.2_Missense_Mutation_p.T165I|LMAN1L_uc010ulo.1_Missense_Mutation_p.T129I|LMAN1L_uc010bke.1_Missense_Mutation_p.T237I	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	237	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GCCACCGGCACCCTGGCAGGT	0.577000													41	45					0	0	8.96297e-05	0	0
CHRNA5	1138	broad.mit.edu	37	15	78885454	78885454	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:78885454C>T	uc002bdy.2	+	6	1428	c.1266C>T	c.(1264-1266)TTC>TTT	p.F422F	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Silent_p.*490*|CHRNA5_uc002bdz.2_Missense_Mutation_p.S160L|CHRNA3_uc010blg.1_RNA	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	422	Cytoplasmic (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATTGGAAATTCATAGCCCAGG	0.308000													56	73					0	0	0.000147903	0	0
STARD5	80765	broad.mit.edu	37	15	81615284	81615284	+	Silent	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr15:81615284T>C	uc002bgm.2	-	2	189	c.105A>G	c.(103-105)GGA>GGG	p.G35G	STARD5_uc002bgn.2_Intron	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	35	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						AAACTGAAACTCCATTCTGTC	0.368000													3	49					0	0	6.4e-05	0	0
OR1F1	4992	broad.mit.edu	37	16	3254585	3254585	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:3254585C>T	uc010uwu.1	+	1	339	c.339C>T	c.(337-339)TTC>TTT	p.F113F		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGACAATTTCCTCCTAGCTG	0.502000													75	91					0	0	0.000147903	0	0
CORO7	79585	broad.mit.edu	37	16	4412724	4412724	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:4412724G>A	uc002cwh.3	-	15	1411	c.1291C>T	c.(1291-1293)CCT>TCT	p.P431S	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.P431S|CORO7_uc002cwg.3_Missense_Mutation_p.P211S|CORO7_uc010uxh.1_Missense_Mutation_p.P413S|CORO7_uc010uxi.1_Missense_Mutation_p.P346S|CORO7_uc002cwi.1_Missense_Mutation_p.P211S|CORO7_uc010uxj.1_RNA|CORO7_uc010btp.1_Missense_Mutation_p.P211S	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	431						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GAACTGGGAGGGGAAGAGAAA	0.667000													5	6					0	0	1.23904e-05	0	0
ACSM1	116285	broad.mit.edu	37	16	20681305	20681305	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:20681305C>T	uc002dhm.1	-	5	824	c.756G>A	c.(754-756)AGG>AGA	p.R252R	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.R252R	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	252					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TCCGTAATTTCCTACTAACTC	0.423000													9	11					0	0	3.86212e-05	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32891002	32891002	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:32891002C>T	uc002edh.1	-	3	228	c.52G>A	c.(52-54)GCC>ACC	p.A18T	SLC6A10P_uc002edi.1_RNA					RecName: Full=Transporter;												0						GTGCCACTGGCTGAGTAGTAG	0.622000													20	19					0	0	0.000229342	0	0
CES2	8824	broad.mit.edu	37	16	66974501	66974501	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:66974501C>T	uc002eqr.2	+	5	1911	c.911C>T	c.(910-912)TCC>TTC	p.S304F	CES2_uc002eqq.2_Missense_Mutation_p.S304F|CES2_uc002eqs.2_Missense_Mutation_p.S147F	NM_003869	NP_003860	O00748	EST2_HUMAN	carboxylesterase 2 isoform 1	240					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CTTGTTGTGTCCCCCATATCC	0.592000													36	34					0	0	0.000191422	0	0
HYDIN	54768	broad.mit.edu	37	16	70926303	70926303	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:70926303C>T	uc002ezr.2	-	56	9503	c.9375G>A	c.(9373-9375)AAG>AAA	p.K3125K		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3126										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TCTTCACTTCCTTTTTTGCAT	0.473000													29	87					0	0	8.91981e-05	0	0
AP1G1	164	broad.mit.edu	37	16	71768553	71768554	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:71768553_71768554CC>AA	uc010cgg.2	-	22	2639_2640	c.2325_2326GG>TT	c.(2323-2328)ACGGGG>ACTTGG	p.G776W	AP1G1_uc002fba.2_Missense_Mutation_p.G779W|AP1G1_uc002fbb.2_Missense_Mutation_p.G799W|AP1G1_uc002faz.2_Missense_Mutation_p.G193W	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	776	GAE.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				GTGATGGTCCCCGTGTTAAATG	0.450000													11	274					0	0	6.4e-05	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501305	76501305	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr16:76501305G>A	uc002feu.1	+	12	1925	c.1540G>A	c.(1540-1542)GGA>AGA	p.G514R	CNTNAP4_uc002fev.1_Missense_Mutation_p.G378R|CNTNAP4_uc010chb.1_Missense_Mutation_p.G441R|CNTNAP4_uc002fex.1_Missense_Mutation_p.G517R|CNTNAP4_uc002few.2_Missense_Mutation_p.G489R	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	514	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGGATTTCAGGGATGTATGAG	0.428000													23	32					0	0	0.000375601	0	0
MYH1	4619	broad.mit.edu	37	17	10411975	10411975	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:10411975G>A	uc002gmo.2	-	16	1696	c.1602C>T	c.(1600-1602)TTC>TTT	p.F534F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	534	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCAGGATGGAGAAGATGCCCA	0.393000													41	46					0	0	0.000106405	0	0
DNAH9	1770	broad.mit.edu	37	17	11511573	11511573	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:11511573G>A	uc002gne.2	+	2	613	c.545G>A	c.(544-546)GGA>GAA	p.G182E	DNAH9_uc002gnd.1_Missense_Mutation_p.G182E	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	182	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAAGTGAAGGGAAAAACTTTG	0.507000													70	90					0	0	0.000147903	0	0
CCT6B	10693	broad.mit.edu	37	17	33269603	33269603	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:33269603G>A	uc002hig.2	-	7	879	c.785C>T	c.(784-786)GCT>GTT	p.A262V	CCT6B_uc010ctg.2_Missense_Mutation_p.A225V|CCT6B_uc010wcc.1_Missense_Mutation_p.A217V	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	262					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TTTTCTTTCAGCTTTTACCAA	0.328000													15	13					0	0	0.000219431	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274368	39274368	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:39274368G>C	uc002hvz.2	-	1	239	c.200C>G	c.(199-201)CCC>CGC	p.P67R		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	67	9.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCATCTGGGGCGGCAGCA	0.637000													3	49					0	0	6.4e-05	0	0
MSI2	124540	broad.mit.edu	37	17	55752363	55752363	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:55752363C>T	uc002iuz.1	+	12	994	c.821C>T	c.(820-822)CCG>CTG	p.P274L	MSI2_uc010wnm.1_Missense_Mutation_p.P270L	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	274						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GGAGGCTTCCCGGGGGCCAAC	0.662000			T	HOXA9	CML								60	52					0	0	0.000147903	0	0
RNF43	54894	broad.mit.edu	37	17	56440957	56440957	+	Missense_Mutation	SNP	C	T	T	rs35219874	byFrequency	TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:56440957C>T	uc002iwf.2	-	3	2336	c.380G>A	c.(379-381)CGG>CAG	p.R127Q	RNF43_uc010wnv.1_Missense_Mutation_p.R86Q|RNF43_uc002iwh.3_Missense_Mutation_p.R127Q|RNF43_uc002iwg.3_Missense_Mutation_p.R127Q|RNF43_uc010dcw.2_5'UTR	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	127	Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACCCGCCATCCGAGCCTGCAG	0.592000													25	24					0	0	5.49717e-05	0	0
EVPL	2125	broad.mit.edu	37	17	74004305	74004306	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:74004305_74004306CC>TT	uc002jqi.2	-	22	5208_5209	c.4980_4981GG>AA	c.(4978-4983)CGGGAC>CGAAAC	p.D1661N	EVPL_uc010wss.1_Missense_Mutation_p.D1683N|EVPL_uc010wst.1_Missense_Mutation_p.D1131N	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1661	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						GCGTGGAGGTCCCGGAGCGTCC	0.668000													23	27					0	0	6.4e-05	0	0
BAHCC1	57597	broad.mit.edu	37	17	79412403	79412403	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr17:79412403G>A	uc002kaf.2	+	8	2859	c.2859G>A	c.(2857-2859)CTG>CTA	p.L953L	BAHCC1_uc002kae.2_Silent_p.L152L	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	953	Pro-rich.						DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			ACCAGCACCTGGATCTGGAGG	0.687000													8	4					0	0	2.17888e-05	0	0
ZADH2	284273	broad.mit.edu	37	18	72914190	72914190	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr18:72914190C>T	uc002llx.2	-	2	583	c.315G>A	c.(313-315)GTG>GTA	p.V105V	ZADH2_uc010dqv.2_5'UTR	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	105						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		GGCCTAGGGCCACCACCTCCC	0.527000													55	62					0	0	0.000147903	0	0
PQLC1	80148	broad.mit.edu	37	18	77679243	77679243	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr18:77679243G>A	uc002lnl.2	-	5	721	c.549C>T	c.(547-549)GCC>GCT	p.A183A	PQLC1_uc010dre.2_Silent_p.A100A|PQLC1_uc002lnk.2_Silent_p.A165A|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	183	PQ-loop 2.|Helical; (Potential).					integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CACCCAGCATGGCTTCGGTCA	0.647000													19	17					0	0	0.000229342	0	0
PLIN4	729359	broad.mit.edu	37	19	4511544	4511545	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:4511544_4511545CC>TT	uc002mar.1	-	3	2385_2386	c.2385_2386GG>AA	c.(2383-2388)GTGGCC>GTAACC	p.A796T	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	796	22.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						GCCCCCTTGGCCACATTCGCAG	0.614000													26	65					0	0	6.4e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9065721	9065721	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:9065721G>A	uc002mkp.2	-	3	21929	c.21725C>T	c.(21724-21726)TCC>TTC	p.S7242F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7244	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCTCAGGGAGGAAATTGACTC	0.468000													66	88					0	0	0.000147903	0	0
CPAMD8	27151	broad.mit.edu	37	19	17122526	17122526	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:17122526C>T	uc002nfb.2	-	4	482	c.450G>A	c.(448-450)TGG>TGA	p.W150*		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	103						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AGCCGCGGCCCCACACTTTCA	0.637000													19	19					0	0	9.7654e-05	0	0
ZNF99	7652	broad.mit.edu	37	19	22939345	22939345	+	Silent	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:22939345T>C	uc010xrh.1	-	7	2826	c.2826A>G	c.(2824-2826)AAA>AAG	p.K942K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATTTGTAGGGTTTCTCTCCAG	0.378000													18	18					0	0	0.000132079	0	0
ZNF468	90333	broad.mit.edu	37	19	53344878	53344878	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:53344878G>A	uc002qaf.2	-	4	820	c.669C>T	c.(667-669)TCC>TCT	p.S223S	ZNF468_uc002qae.2_Silent_p.S170S	NM_001008801	NP_001008801	Q5VIY5	ZN468_HUMAN	zinc finger protein ZNF468 isoform 2	223	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0358)		TGCAATTAAAGGATTTGAAGC	0.323000													37	35					0	0	0.000159656	0	0
VN1R2	317701	broad.mit.edu	37	19	53761927	53761927	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:53761927G>A	uc002qbi.2	+	1	383	c.299G>A	c.(298-300)GGA>GAA	p.G100E		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	100	Helical; Name=2; (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		GTAGTTGTTGGAATCCTGGGG	0.229000													10	19					0	0	2.17888e-05	0	0
ZNF749	388567	broad.mit.edu	37	19	57956103	57956103	+	Silent	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr19:57956103T>C	uc002qoq.2	+	3	1841	c.1587T>C	c.(1585-1587)CAT>CAC	p.H529H	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	529	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAGTTCAGCATGAGAAAATCC	0.453000													3	90					0	0	1.23904e-05	0	0
APOB	338	broad.mit.edu	37	2	21227542	21227543	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:21227542_21227543CC>AA	uc002red.2	-	27	11921_11922	c.11793_11794GG>TT	c.(11791-11796)TTGGGA>TTTTGA	p.3931_3932LG>F*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3931_3932					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGTGTGTTCCCAAAACTGTAT	0.361000													12	485					0	0	6.4e-05	0	0
APOB	338	broad.mit.edu	37	2	21234140	21234141	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:21234140_21234141CG>AT	uc002red.2	-	26	5727_5728	c.5599_5600CG>AT	c.(5599-5601)CGG>ATG	p.R1867M		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1867				R -> G (in Ref. 4; AAB04636).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTGTTGAGCCGATGGCTAAAC	0.441000													8	456					0	0	6.4e-05	0	0
RASGRP3	25780	broad.mit.edu	37	2	33745056	33745056	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:33745056C>T	uc002rox.2	+	6	838	c.211C>T	c.(211-213)CGA>TGA	p.R71*	RASGRP3_uc010ync.1_Nonsense_Mutation_p.R71*|RASGRP3_uc002roy.2_Nonsense_Mutation_p.R71*	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	71	N-terminal Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					CAATGAATTTCGATTAAAGAT	0.383000													15	13					0	0	0.000175454	0	0
NPAS2	4862	broad.mit.edu	37	2	101609880	101609880	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:101609880C>T	uc002tap.1	+	20	2469	c.2183C>T	c.(2182-2184)CCC>CTC	p.P728L	NPAS2_uc010yvt.1_Missense_Mutation_p.P793L|NPAS2_uc010fit.1_Silent_p.A145A	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	728					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						GCCCCGATGCCCGTCCTGCTG	0.657000													7	16					0	0	8.12818e-05	0	0
DPP10	57628	broad.mit.edu	37	2	116510813	116510813	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:116510813C>T	uc002tla.1	+	11	1471	c.1014C>T	c.(1012-1014)AAC>AAT	p.N338N	DPP10_uc002tlb.1_Silent_p.N288N|DPP10_uc002tlc.1_Silent_p.N334N|DPP10_uc002tle.2_Silent_p.N342N|DPP10_uc002tlf.1_Silent_p.N331N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	338	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GATGGTTAAACCGAGCTCAGA	0.348000													25	29					0	0	9.22233e-05	0	0
GTDC1	79712	broad.mit.edu	37	2	144710388	144710388	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:144710388A>G	uc002tvp.2	-	10	1432	c.1153T>C	c.(1153-1155)TGT>CGT	p.C385R	GTDC1_uc002tvo.2_Silent_p.G336G|GTDC1_uc002tvq.2_Missense_Mutation_p.C267R|GTDC1_uc002tvr.2_Missense_Mutation_p.C300R|GTDC1_uc010fnn.2_Missense_Mutation_p.C385R|GTDC1_uc002tvs.2_Missense_Mutation_p.C353R|GTDC1_uc010fno.2_Missense_Mutation_p.C256R	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	385					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		AGTGGGTAACACCCACAGTAC	0.333000													70	90					0	0	0.000147903	0	0
CCDC148	130940	broad.mit.edu	37	2	159035397	159035397	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:159035397C>T	uc002tzq.2	-	12	1745	c.1482G>A	c.(1480-1482)AGG>AGA	p.R494R	CCDC148_uc002tzr.2_Silent_p.R342R|CCDC148_uc010foh.2_Silent_p.R207R	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	494	Potential.									ovary(2)	2						ACACCTGTTTCCTAAGGGCTT	0.393000													28	42					0	0	0.000184323	0	0
KCNH7	90134	broad.mit.edu	37	2	163302839	163302839	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:163302839G>A	uc002uch.1	-	7	1455	c.1243C>T	c.(1243-1245)CTG>TTG	p.L415L	KCNH7_uc002uci.2_Silent_p.L408L	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	415	Helical; Name=Segment S1; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ACCAACAGCAGGATAAGCCAG	0.453000													20	38					0	0	0.000132079	0	0
LRP2	4036	broad.mit.edu	37	2	170002377	170002377	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:170002377C>T	uc002ues.2	-	70	13081	c.12868G>A	c.(12868-12870)GAA>AAA	p.E4290K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4290	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCTCCCTTTTCCTTAGATATC	0.398000													20	24					0	0	9.7654e-05	0	0
TTN	7273	broad.mit.edu	37	2	179644801	179644801	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:179644801C>T	uc010zfg.1	-	22	3879	c.3655G>A	c.(3655-3657)GAA>AAA	p.E1219K	TTN_uc010zfh.1_Missense_Mutation_p.E1173K|TTN_uc010zfi.1_Missense_Mutation_p.E1173K|TTN_uc010zfj.1_Missense_Mutation_p.E1173K|TTN_uc002unb.2_Missense_Mutation_p.E1219K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1219							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTtctttttcatactctttt	0.323000													43	53					0	0	0.000374591	0	0
SDPR	8436	broad.mit.edu	37	2	192701377	192701377	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:192701377C>T	uc002utb.2	-	2	880	c.550G>A	c.(550-552)GAG>AAG	p.E184K		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	184						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GGAAGCTCCTCCTTCCCTTCC	0.522000													17	22					0	0	7.07596e-05	0	0
CTDSP1	58190	broad.mit.edu	37	2	219266858	219266858	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:219266858C>T	uc002vhy.2	+	3	577	c.241C>T	c.(241-243)CCT>TCT	p.P81S	CTDSP1_uc002vhx.2_Missense_Mutation_p.P80S|CTDSP1_uc002vhz.2_5'UTR|uc010zkd.1_5'Flank|MIR26B_hsa-mir-26b|MI0000084_5'Flank	NM_021198	NP_067021	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	81					protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			ovary(1)	1		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATACCTGCTCCCTGAGGCCAA	0.652000													11	13					0	0	0.000308642	0	0
STK36	27148	broad.mit.edu	37	2	219538675	219538675	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:219538675A>G	uc002viu.2	+	4	565	c.299A>G	c.(298-300)GAC>GGC	p.D100G	STK36_uc002viv.2_Missense_Mutation_p.D100G|RNF25_uc002vit.2_5'Flank|RNF25_uc010fvw.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	100	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTTCCTGAAGACCAGGTATGC	0.502000													12	12					0	0	0.00010058	0	0
C2orf85	285093	broad.mit.edu	37	2	242814522	242814522	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr2:242814522G>A	uc010fzu.1	+	2	838	c.815G>A	c.(814-816)GGC>GAC	p.G272D		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	272						integral to membrane				ovary(1)	1						CTCTTCCACGGCCCCGGCCTC	0.672000													15	41					0	0	7.07596e-05	0	0
BMP2	650	broad.mit.edu	37	20	6759423	6759423	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr20:6759423A>C	uc002wmu.1	+	3	1663	c.878A>C	c.(877-879)AAG>ACG	p.K293T		NM_001200	NP_001191	P12643	BMP2_HUMAN	bone morphogenetic protein 2 preproprotein	293					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			ovary(1)|breast(1)	2					Simvastatin(DB00641)	AAACGCCTTAAGTCCAGCTGT	0.498000													14	30					0	0	0.000219431	0	0
TPTE	7179	broad.mit.edu	37	21	10996106	10996106	+	RNA	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr21:10996106C>T	uc002yis.1	-	12		c.2080G>A						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTGCCCAGTTCGACTTCTTTG	0.413000													15	51					0	0	0.000175454	0	0
RCAN1	1827	broad.mit.edu	37	21	35895913	35895913	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr21:35895913G>A	uc002yue.2	-	2	420	c.348C>T	c.(346-348)CCC>CCT	p.P116P	RCAN1_uc002yuc.2_Silent_p.P35P|RCAN1_uc002yud.2_5'UTR|RCAN1_uc002yub.2_Silent_p.P61P|RCAN1_uc011adx.1_Silent_p.P61P	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	116					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						CTGCGGAGAAGGGGTTGCTGA	0.438000													264	36					0	0	0.000147903	0	0
PRAME	23532	broad.mit.edu	37	22	22890563	22890563	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr22:22890563G>A	uc002zwf.2	-	5	1612	c.1456C>T	c.(1456-1458)CCC>TCC	p.P486S	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.P470S|PRAME_uc010gtr.2_Missense_Mutation_p.P486S|PRAME_uc002zwg.2_Missense_Mutation_p.P486S|PRAME_uc002zwh.2_Missense_Mutation_p.P486S|PRAME_uc002zwi.2_Missense_Mutation_p.P486S|PRAME_uc002zwj.2_Missense_Mutation_p.P486S|PRAME_uc002zwk.2_Missense_Mutation_p.P486S	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	486	Mediates interaction with RARA.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TGAGGACAGGGGTTGGCACTA	0.572000													49	55					0	0	0.000147903	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657755	46657755	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr22:46657755C>T	uc003bhh.2	-	1	1465	c.1465G>A	c.(1465-1467)GAT>AAT	p.D489N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	489	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TTATAGAAATCACGGCTTGCA	0.378000													94	114					0	0	0.000147903	0	0
ZNF385D	79750	broad.mit.edu	37	3	21467028	21467028	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:21467028C>T	uc003cce.2	-	6	1216	c.808G>A	c.(808-810)GAA>AAA	p.E270K		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	270	Matrin-type 3.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						TCACAGATTTCACAGTGAAAT	0.433000													63	58					0	0	0.000147903	0	0
CCR4	1233	broad.mit.edu	37	3	32995259	32995259	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:32995259G>A	uc003cfg.1	+	2	513	c.345G>A	c.(343-345)TGG>TGA	p.W115*		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	115	Helical; Name=3; (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						TGATTTCCTGGATGTACTTGG	0.483000													117	124					0	0	0.000147903	0	0
HHATL	57467	broad.mit.edu	37	3	42734610	42734610	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:42734610A>G	uc003clw.2	-	12	1496	c.1349T>C	c.(1348-1350)CTC>CCC	p.L450P	HHATL_uc003clx.2_Missense_Mutation_p.L450P	NM_020707	NP_065758	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	450					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				ovary(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TGTGAATTTGAGGCTGTTCAG	0.582000													5	128					0	0	3.59834e-05	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917159	42917159	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:42917159C>T	uc003cmh.2	-	1	475	c.150G>A	c.(148-150)CGG>CGA	p.R50R	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Silent_p.R50R	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	50					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		ACATATTCTTCCGGAAAGCCA	0.582000													13	35					0	0	0.000308642	0	0
PXK	54899	broad.mit.edu	37	3	58395340	58395340	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:58395340C>T	uc003djz.1	+	15	1489	c.1390C>T	c.(1390-1392)CGA>TGA	p.R464*	PXK_uc003djx.1_Nonsense_Mutation_p.R464*|PXK_uc003djy.1_Nonsense_Mutation_p.R447*|PXK_uc003dka.1_Nonsense_Mutation_p.R464*|PXK_uc003dkb.1_Nonsense_Mutation_p.R381*|PXK_uc003dkc.1_Nonsense_Mutation_p.R447*|PXK_uc011bfe.1_Nonsense_Mutation_p.R431*|PXK_uc010hnj.1_Nonsense_Mutation_p.R431*|PXK_uc003dkd.1_Nonsense_Mutation_p.R327*|PXK_uc010hnk.1_Nonsense_Mutation_p.R238*	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	464	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		GATTTTAGCTCGAAAGGTAAG	0.418000													7	5					0	0	8.12818e-05	0	0
Unknown	0	broad.mit.edu	37	3	95374381	95374381	+	RNA	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:95374381C>T	uc003dro.1	-	5		c.1481G>A								Homo sapiens cDNA FLJ34909 fis, clone NT2RI2009301, moderately similar to BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR.																		GTCCTACATTCATTACAGGAA	0.463000													25	20					0	0	0.000117367	0	0
MORC1	27136	broad.mit.edu	37	3	108813812	108813812	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:108813812G>A	uc003dxl.2	-	7	614	c.527C>T	c.(526-528)CCA>CTA	p.P176L	MORC1_uc011bhn.1_Missense_Mutation_p.P176L	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	176					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AGTTTTAAATGGGGAGTATTT	0.343000													21	26					0	0	0.000175454	0	0
PIK3CB	5291	broad.mit.edu	37	3	138461467	138461468	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:138461467_138461468GG>TT	uc011bmq.1	-	3	553_554	c.553_554CC>AA	c.(553-555)CCT>AAT	p.P185N		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	185	PI3K-RBD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TAAGTTTTCAGGGATGGATGGT	0.366000													22	518					0	0	6.4e-05	0	0
OTOL1	131149	broad.mit.edu	37	3	161214696	161214696	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr3:161214696A>C	uc011bpb.1	+	1	101	c.101A>C	c.(100-102)AAA>ACA	p.K34T		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	34						collagen					0						TTTACGAAGAAATCTGAGGAA	0.413000													12	20					0	0	6.40141e-05	0	0
PDE6B	5158	broad.mit.edu	37	4	647869	647869	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr4:647869G>A	uc003gap.2	+	5	906	c.853G>A	c.(853-855)GAA>AAA	p.E285K	PDE6B_uc003gao.3_Missense_Mutation_p.E285K|PDE6B_uc011buy.1_Missense_Mutation_p.E6K|PDE6B_uc010ibg.2_Missense_Mutation_p.E6K|uc003gaq.1_RNA	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	285	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						CTCTGCCCAGGAATTTTTTGA	0.662000													23	29					0	0	0.000117367	0	0
YIPF7	285525	broad.mit.edu	37	4	44638040	44638040	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr4:44638040G>A	uc010ifx.1	-	3	268	c.251C>T	c.(250-252)TCG>TTG	p.S84L	YIPF7_uc010ify.1_Missense_Mutation_p.S84L	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	84						endoplasmic reticulum membrane|integral to membrane					0						TGCGTAACCCGATGACATGAG	0.408000													31	32					0	0	0.000339439	0	0
PCDH18	54510	broad.mit.edu	37	4	138451637	138451637	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr4:138451637C>T	uc003ihe.3	-	1	1993	c.1606G>A	c.(1606-1608)GAA>AAA	p.E536K	PCDH18_uc003ihf.3_Missense_Mutation_p.E529K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E316K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	536	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					CTCACTTCTTCATGATCAAAG	0.428000													47	73					0	0	0.000147903	0	0
FGA	2243	broad.mit.edu	37	4	155507077	155507077	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr4:155507077C>T	uc003iod.1	-	5	1562	c.1504G>A	c.(1504-1506)GGC>AGC	p.G502S	FGA_uc003ioe.1_Missense_Mutation_p.G502S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	502	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GTACCTATGCCAGACAATGTG	0.493000													41	58					0	0	0.000374591	0	0
DNAH5	1767	broad.mit.edu	37	5	13820543	13820543	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:13820543C>T	uc003jfd.2	-	41	6795	c.6753G>A	c.(6751-6753)ACG>ACA	p.T2251T		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2251	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GCACTCTCTGCGTTTCGAATA	0.507000									Kartagener_syndrome				19	26					0	0	9.7654e-05	0	0
CDH12	1010	broad.mit.edu	37	5	21842363	21842363	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:21842363C>T	uc010iuc.2	-	5	1179	c.721G>A	c.(721-723)GAT>AAT	p.D241N	CDH12_uc011cno.1_Missense_Mutation_p.D201N|CDH12_uc003jgk.2_Missense_Mutation_p.D241N	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	241	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CCTCCCATATCCTTGGCTTGG	0.413000										HNSCC(59;0.17)			42	54					0	0	0.000374591	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954490	35954490	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:35954490G>A	uc003jjv.1	-	7	1543	c.1386C>T	c.(1384-1386)ATC>ATT	p.I462I	UGT3A1_uc003jjw.1_RNA	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	462	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CAGTCTGGAGGATGTGGTCGA	0.612000													14	15					0	0	0.000219431	0	0
PIK3R1	5295	broad.mit.edu	37	5	67589664	67589664	+	Splice_Site	SNP	T	G	G			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:67589664T>G	uc003jva.2	+	11	1985	c.1425_splice	c.e11+2	p.Q475_splice	PIK3R1_uc003jvb.2_Splice_Site_p.Q475_splice|PIK3R1_uc003jvc.2_Splice_Site_p.Q175_splice|PIK3R1_uc003jvd.2_Splice_Site_p.Q205_splice|PIK3R1_uc003jve.2_Splice_Site_p.Q154_splice|PIK3R1_uc011crb.1_Splice_Site_p.Q145_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(2)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	ACATCCCAGGTGAGTTTTCTA	0.294000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			23	43					0	0	5.49717e-05	0	0
LIX1	167410	broad.mit.edu	37	5	96443096	96443096	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:96443096C>T	uc003kmy.3	-	3	595	c.355G>A	c.(355-357)GAA>AAA	p.E119K		NM_153234	NP_694966	Q8N485	LIX1_HUMAN	limb expression 1	119										ovary(1)	1		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		TGAACACTTTCCATAATGAAT	0.527000													51	51					0	0	0.000147903	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101709073	101709073	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:101709073C>T	uc003knn.2	-	13	2315	c.2143G>A	c.(2143-2145)GAA>AAA	p.E715K	SLCO6A1_uc003kno.2_Missense_Mutation_p.E462K|SLCO6A1_uc003knp.2_Missense_Mutation_p.E715K|SLCO6A1_uc003knq.2_Missense_Mutation_p.E653K	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	715	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TCAGTTTCTTCTTTTTTCTTA	0.269000													36	62					0	0	0.000106405	0	0
PPIC	5480	broad.mit.edu	37	5	122361653	122361653	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:122361653G>A	uc003kth.2	-	4	441	c.336C>T	c.(334-336)ATC>ATT	p.I112I		NM_000943	NP_000934	P45877	PPIC_HUMAN	peptidylprolyl isomerase C	112	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			ovary(1)	1		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	TCTCACCATAGATGCTCACAC	0.463000													12	16					0	0	6.40141e-05	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754153	140754153	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:140754153A>T	uc003ljy.1	+	1	503	c.503A>T	c.(502-504)CAG>CTG	p.Q168L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.Q168L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	168	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACTCCCTTCAGGGATTTAAG	0.507000													17	16					0	0	5.01169e-05	0	0
ERGIC1	57222	broad.mit.edu	37	5	172315753	172315753	+	Silent	SNP	C	G	G	rs149114698		TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:172315753C>G	uc003mbw.3	+	2	266	c.72C>G	c.(70-72)ACC>ACG	p.T24T		NM_001031711	NP_001026881	Q969X5	ERGI1_HUMAN	endoplasmic reticulum-golgi intermediate	24	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAACGTACACCGGGGCCATTA	0.557000													3	39					0	0	6.4e-05	0	0
CDHR2	54825	broad.mit.edu	37	5	176016402	176016402	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:176016402C>T	uc003mem.1	+	23	3146	c.3080C>T	c.(3079-3081)TCC>TTC	p.S1027F	CDHR2_uc003men.1_Missense_Mutation_p.S1027F	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1027	Extracellular (Potential).|Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GACAGACCTTCCTTGGGTCCT	0.662000													36	54					0	0	0.000159656	0	0
AGXT2L2	85007	broad.mit.edu	37	5	177649539	177649539	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr5:177649539G>A	uc003miz.2	-	8	996	c.744C>T	c.(742-744)ATC>ATT	p.I248I	AGXT2L2_uc003miy.2_Intron|AGXT2L2_uc003mjc.2_Silent_p.I207I|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_Intron|AGXT2L2_uc003mjd.1_Silent_p.I106I	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	248						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AGCCAACCTGGATCTCATCTG	0.463000													32	49					0	0	0.000159656	0	0
FAM136B	387071	broad.mit.edu	37	6	3045940	3045941	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:3045940_3045941AC>TT	uc011dhr.1	+	1	323_324	c.323_324AC>TT	c.(322-324)GAC>GTT	p.D108V		NM_001012983	NP_001013001			hypothetical protein LOC387071												0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				CAGCAGCTGGACGGTTGTGTGA	0.480000													8	115					0	0	6.4e-05	0	0
FAM136B	387071	broad.mit.edu	37	6	3045944	3045944	+	Silent	SNP	T	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:3045944T>C	uc011dhr.1	+	1	327	c.327T>C	c.(325-327)GGT>GGC	p.G109G		NM_001012983	NP_001013001			hypothetical protein LOC387071												0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AGCTGGACGGTTGTGTGACCA	0.483000													8	108					0	0	0.000274275	0	0
LY86	9450	broad.mit.edu	37	6	6589096	6589096	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:6589096G>A	uc003mwy.1	+	1	163	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	LOC285780_uc003mww.3_Intron|LOC285780_uc003mwx.2_Intron	NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	43					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					TGCTCTACCAGAGTTGCGGTA	0.582000													16	65					0	0	5.01169e-05	0	0
HFE	3077	broad.mit.edu	37	6	26092986	26092986	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:26092986C>T	uc003nfx.1	+	4	850	c.690C>T	c.(688-690)TAC>TAT	p.Y230Y	HFE_uc003nfy.1_Silent_p.Y207Y|HFE_uc010jqe.1_Silent_p.Y227Y|HFE_uc003nfz.1_Silent_p.Y142Y|HFE_uc003ngd.1_Silent_p.Y128Y|HFE_uc003nga.1_Silent_p.Y216Y|HFE_uc003ngb.1_Silent_p.Y124Y|HFE_uc003ngc.1_Silent_p.Y138Y|HFE_uc003nge.1_Silent_p.Y50Y|HFE_uc003ngf.1_Intron	NM_000410	NP_000401	Q30201	HFE_HUMAN	hemochromatosis protein isoform 1 precursor	230	Alpha-3.|Ig-like C1-type.|Extracellular (Potential).			Y -> H (in Ref. 7; AAG29342).	antigen processing and presentation of peptide antigen via MHC class I|cellular iron ion homeostasis|immune response|iron ion transport|protein complex assembly|receptor-mediated endocytosis	apical part of cell|basal part of cell|cytoplasmic vesicle|early endosome|integral to plasma membrane|MHC class I protein complex|perinuclear region of cytoplasm|recycling endosome	protein binding				0						CCTTGAACTACTACCCCCAGA	0.512000									Hemochromatosis				6	148					0	0	8.12818e-05	0	0
TRIM26	7726	broad.mit.edu	37	6	30156976	30156976	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:30156976C>T	uc003npr.2	-	8	1114	c.905G>A	c.(904-906)GGG>GAG	p.G302E	TRIM26_uc003nps.2_Missense_Mutation_p.G302E|TRIM26_uc010jry.2_Missense_Mutation_p.G32E|TRIM26_uc003npt.2_Missense_Mutation_p.G302E	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	302	B30.2/SPRY.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						CAGCAGCTTCCCTGGGGAGAA	0.443000													37	118					0	0	0.000191422	0	0
BAT3	7917	broad.mit.edu	37	6	31610864	31610864	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:31610864C>T	uc003nvg.3	-	14	2009	c.1695G>A	c.(1693-1695)CCG>CCA	p.P565P	BAT3_uc003nvf.3_Silent_p.P559P|BAT3_uc003nvh.3_Silent_p.P559P|BAT3_uc003nvi.3_Silent_p.P559P|BAT3_uc011dnw.1_Silent_p.P559P|BAT3_uc011dnx.1_Intron	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	565	Pro-rich.|4 X 29 AA approximate repeats.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CAGGGGCTGGCGGTGGAGCCA	0.498000													42	162					0	0	0.000125731	0	0
ANKS1A	23294	broad.mit.edu	37	6	34985592	34985592	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:34985592C>T	uc003ojx.3	+	11	1908	c.1766C>T	c.(1765-1767)TCT>TTT	p.S589F	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.S129F|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	589						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						CACACAGCATCTCCGCACCCT	0.627000													77	123					0	0	0.000147903	0	0
MEP1A	4224	broad.mit.edu	37	6	46806764	46806764	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:46806764C>T	uc010jzh.1	+	14	2174	c.2132C>T	c.(2131-2133)GCC>GTC	p.A711V	MEP1A_uc011dwg.1_Missense_Mutation_p.A433V|MEP1A_uc011dwh.1_Missense_Mutation_p.A739V|MEP1A_uc011dwi.1_Missense_Mutation_p.A611V	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	711	Extracellular (Potential).			AVQ -> SAE (in Ref. 1; AAA21338 and 7; no nucleotide entry).	digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			CGCTGTCAGGCCGTGCAGGTG	0.592000													47	238					0	0	0.000147903	0	0
GPR115	221393	broad.mit.edu	37	6	47682279	47682279	+	Missense_Mutation	SNP	C	T	T	rs146828294	by1000genomes	TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:47682279C>T	uc003oza.1	+	6	1556	c.1298C>T	c.(1297-1299)ACG>ATG	p.T433M	GPR115_uc003oyz.1_Missense_Mutation_p.T490M|GPR115_uc003ozb.1_Missense_Mutation_p.T431M	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	433	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GTGGTTGTGACGGAGATATCA	0.478000													50	171					0	0	0.000147903	0	0
SNAP91	9892	broad.mit.edu	37	6	84303449	84303449	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:84303449G>A	uc011dze.1	-	17	1761	c.1444C>T	c.(1444-1446)CCG>TCG	p.P482S	SNAP91_uc011dzd.1_5'UTR|SNAP91_uc003pkb.2_Missense_Mutation_p.P445S|SNAP91_uc003pkc.2_Missense_Mutation_p.P480S|SNAP91_uc003pkd.2_Intron|SNAP91_uc003pka.2_Missense_Mutation_p.P480S	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	482	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CCTTCAGACGGGGCAAAGGGG	0.498000													26	38					0	0	0.000184323	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671403	112671403	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:112671403G>A	uc003pvx.1	+	3	805	c.493G>A	c.(493-495)GAG>AAG	p.E165K		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	165	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CGTCTGCAAGGAGCCGGCTGA	0.552000													32	43					0	0	0.000339439	0	0
RFX6	222546	broad.mit.edu	37	6	117248601	117248601	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr6:117248601C>T	uc003pxm.2	+	17	2360	c.2297C>T	c.(2296-2298)TCA>TTA	p.S766L		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	766					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GCCCAGGATTCACACAATATG	0.502000													25	29					0	0	5.49717e-05	0	0
CHST12	55501	broad.mit.edu	37	7	2472823	2472823	+	Silent	SNP	C	T	T	rs150939856		TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr7:2472823C>T	uc003smc.2	+	2	684	c.549C>T	c.(547-549)ATC>ATT	p.I183I	CHST12_uc003smd.2_Silent_p.I183I	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	183	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GCGTGATGATCGTGCTGAGCG	0.677000													26	27					0	0	0.000117367	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997096	82997096	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr7:82997096C>T	uc003uhy.1	-	17	2600	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	712					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TGCAAGAATTCCTTGTACCAT	0.458000													43	62					0	0	0.000437636	0	0
CDK6	1021	broad.mit.edu	37	7	92355060	92355060	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr7:92355060G>A	uc011khw.1	-	4	829	c.417C>T	c.(415-417)CAC>CAT	p.H139H	CDK6_uc010lez.2_Silent_p.H139H	NM_001259	NP_001250	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	139	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			central_nervous_system(1)|skin(1)	2	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GCACTACTCGGTGTGAATGAA	0.423000			T	MLLT10	ALL								92	78					0	0	0.000147903	0	0
LRRC4	64101	broad.mit.edu	37	7	127669173	127669173	+	Silent	SNP	G	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr7:127669173G>C	uc003vmk.2	-	2	1658	c.1521C>G	c.(1519-1521)CCC>CCG	p.P507P	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	507	Thr-rich.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		TGTCTGTCGCGGGTACTGCCA	0.552000													3	42					0	0	6.4e-05	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				33	48					0	0	0.000159656	0	0
CSMD1	64478	broad.mit.edu	37	8	2823455	2823455	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:2823455C>T	uc011kwk.1	-	59	9515	c.9125G>A	c.(9124-9126)GGC>GAC	p.G3042D	CSMD1_uc011kwj.1_Missense_Mutation_p.G2371D|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3042	Extracellular (Potential).|Sushi 24.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCTAGTGTGCCTGGATCCCC	0.413000													5	9					0	0	3.59834e-05	0	0
MCM4	4173	broad.mit.edu	37	8	48883186	48883186	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:48883186C>T	uc003xqk.1	+	12	1645	c.1550C>T	c.(1549-1551)TCC>TTC	p.S517F	MCM4_uc003xql.1_Missense_Mutation_p.S517F|MCM4_uc011ldi.1_Missense_Mutation_p.S504F	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	517	ATP (Potential).|MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ACCAGCAAGTCCCAGCTGCTG	0.557000													21	21					0	0	0.000295444	0	0
SNTG1	54212	broad.mit.edu	37	8	51705237	51705237	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:51705237G>A	uc010lxy.1	+	20	1773	c.1402G>A	c.(1402-1404)GAA>AAA	p.E468K	SNTG1_uc003xqs.1_Missense_Mutation_p.E468K|SNTG1_uc010lxz.1_Missense_Mutation_p.E431K|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	468					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCAGGAGTTGGAATTTTCTAA	0.318000													42	76					0	0	0.000147903	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618106	77618106	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:77618106C>T	uc003yav.2	+	2	2170	c.1783C>T	c.(1783-1785)CCG>TCG	p.P595S	ZFHX4_uc003yat.1_Missense_Mutation_p.P595S|ZFHX4_uc003yau.1_Missense_Mutation_p.P595S|ZFHX4_uc003yaw.1_Missense_Mutation_p.P595S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	595						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGCTTTACCCCGAGTACTCC	0.587000										HNSCC(33;0.089)			25	25					0	0	7.16444e-05	0	0
CALB1	793	broad.mit.edu	37	8	91081382	91081382	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:91081382C>T	uc003yel.1	-	4	497	c.315G>A	c.(313-315)AAG>AAA	p.K105K	CALB1_uc011lge.1_Silent_p.K48K	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	105	EF-hand 3.					nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TTTCTTATACCTTCATGAATT	0.378000													29	39					0	0	0.000279167	0	0
INTS8	55656	broad.mit.edu	37	8	95862267	95862268	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:95862267_95862268CC>AA	uc003yhb.2	+	12	1581_1582	c.1455_1456CC>AA	c.(1453-1458)TCCCCT>TCAACT	p.P486T	INTS8_uc003yha.1_Missense_Mutation_p.P486T|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.P313T	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	486					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					GGAAGAGATCCCCTAGAGTAAA	0.391000													14	464					0	0	6.4e-05	0	0
GPR20	2843	broad.mit.edu	37	8	142367088	142367088	+	Silent	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr8:142367088G>A	uc003ywf.2	-	2	1025	c.936C>T	c.(934-936)TTC>TTT	p.F312F		NM_005293	NP_005284	Q99678	GPR20_HUMAN	G protein-coupled receptor 20	312	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(97;4.32e-16)|all_epithelial(106;6.61e-14)|Lung NSC(106;9.4e-06)|all_lung(105;1.35e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0415)			CGTGCTGGCCGAAGAGGCCTC	0.652000													30	44					0	0	0.000227799	0	0
Unknown	0	broad.mit.edu	37	9	66513864	66513864	+	RNA	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:66513864C>T	uc010mnh.1	-	6		c.884G>A								Homo sapiens cDNA FLJ20444 fis, clone KAT05128.																		TGACCTGCTCCTGCGGAAGGA	0.502000													17	81					0	0	7.16444e-05	0	0
PCSK5	5125	broad.mit.edu	37	9	78547391	78547391	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:78547391G>A	uc004ajz.2	+	2	827	c.289G>A	c.(289-291)GAA>AAA	p.E97K	PCSK5_uc004ajy.2_Missense_Mutation_p.E97K|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	97					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CATTTCAATGGAACCAAAGGT	0.478000													25	30					0	0	9.22233e-05	0	0
WNK2	65268	broad.mit.edu	37	9	95993351	95993351	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:95993351G>A	uc004ati.1	+	3	1036	c.1036G>A	c.(1036-1038)GCC>ACC	p.A346T	WNK2_uc011lud.1_Missense_Mutation_p.A346T|WNK2_uc004atj.2_Missense_Mutation_p.A346T|WNK2_uc010mrc.1_Missense_Mutation_p.A346T|WNK2_uc010mrd.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	346	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CTTGGGCCTGGCCACTCTGAA	0.537000													69	88					0	0	0.000147903	0	0
Unknown	0	broad.mit.edu	37	9	99884092	99884092	+	RNA	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:99884092C>T	uc004aww.1	-	2		c.1702G>A								Homo sapiens cDNA FLJ34611 fis, clone KIDNE2014112.																		ATGAATAAGCCTGCGGCTGAT	0.562000													6	8					0	0	0.000157383	0	0
PPP3R2	5535	broad.mit.edu	37	9	104356816	104356816	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:104356816G>A	uc004bbr.2	-	1	468	c.397C>T	c.(397-399)CAG>TAG	p.Q133*	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	130	EF-hand 4.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	ACCAGCTGCTGGAGCTGCCAG	0.512000													26	32					0	0	7.16444e-05	0	0
ST6GALNAC4	27090	broad.mit.edu	37	9	130672310	130672310	+	Silent	SNP	G	A	A	rs138532276		TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chr9:130672310G>A	uc004bss.2	-	5	915	c.639C>T	c.(637-639)ACC>ACT	p.T213T	ST6GALNAC4_uc004bst.2_Silent_p.T129T	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	213	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						TGAACCAGCCGGTGCTGAGGA	0.657000													19	23					0	0	0.000175454	0	0
CXorf59	286464	broad.mit.edu	37	X	36091273	36091273	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chrX:36091273G>A	uc004ddk.1	+	4	394	c.208G>A	c.(208-210)GAA>AAA	p.E70K		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	70						integral to membrane				central_nervous_system(1)	1						AGTACTGCCTGAAAATTTGCA	0.348000													25	0					0	0	5.49717e-05	0	0
ATRX	546	broad.mit.edu	37	X	76912109	76912109	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chrX:76912109C>T	uc004ecp.3	-	13	4387	c.4155G>A	c.(4153-4155)CAG>CAA	p.Q1385Q	ATRX_uc004ecq.3_Silent_p.Q1347Q|ATRX_uc004eco.3_Silent_p.Q1170Q|ATRX_uc004ecr.2_Silent_p.Q1317Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1385					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CTCCTGATTCCTGAAAATCAG	0.274000			Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						44	3					0	0	0.000147903	0	0
NRK	203447	broad.mit.edu	37	X	105167175	105167175	+	Silent	SNP	C	T	T			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chrX:105167175C>T	uc004emd.2	+	18	2979	c.2676C>T	c.(2674-2676)GGC>GGT	p.G892G	NRK_uc010npc.1_Silent_p.G560G	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	892							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						AATGGGTAGGCTATAATGCAC	0.423000										HNSCC(51;0.14)			67	8					0	0	0.000147903	0	0
RBMY1A3P	286557	broad.mit.edu	37	Y	9160442	9160442	+	RNA	SNP	A	C	C			TCGA-FS-A1ZN-01A-11D-A197-08	TCGA-FS-A1ZN-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	53bb4480-3c66-4998-bdba-a871ee0c1cd1	a9fd2e01-fa09-4103-b371-1da126c46528	g.chrY:9160442A>C	uc004frl.1	-	1		c.42T>G				NR_001547				Homo sapiens RBMY1A3P pseudogene, mRNA sequence.												0						TTGAGGCCACAAATGAAAAGC	0.313000													2	1					0	0	6.4e-05	0	0
