Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CALML6	163688	broad.mit.edu	37	1	1848280	1848280	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:1848280G>A	uc001aih.1	+	4	797	c.343G>A	c.(343-345)GCA>ACA	p.A115T		NM_138705	NP_619650	Q8TD86	CALL6_HUMAN	calmodulin-like 6	115	EF-hand 3.					cytoplasm|nucleus	calcium ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GCTGAGGGCGGCATTCCGTGT	0.597000													7	649					0	0	0.029380	0	0
CLCNKA	1187	broad.mit.edu	37	1	16356526	16356526	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:16356526G>A	uc001axu.2	+	14	1444	c.1364G>A	c.(1363-1365)GGA>GAA	p.G455E	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.G455E|CLCNKA_uc010obw.1_Missense_Mutation_p.G412E|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_Missense_Mutation_p.G102E|CLCNKA_uc010oby.1_Missense_Mutation_p.G191E	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	455	Helical; (Potential).				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	ATTGTGACTGGAGGGGTTACC	0.662000													15	298					0	0	0.028581	0	0
CSMD2	114784	broad.mit.edu	37	1	34285425	34285425	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:34285425C>T	uc001bxn.1	-	9	1122	c.1093G>A	c.(1093-1095)GTC>ATC	p.V365I	CSMD2_uc001bxm.1_Missense_Mutation_p.V405I	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	365	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGAACTGGACGCTGGATCCT	0.592000													13	246					0	0	0.016723	0	0
HMGB4	127540	broad.mit.edu	37	1	34329991	34329991	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:34329991G>A	uc001bxp.2	+	2	1942	c.199G>A	c.(199-201)GAC>AAC	p.D67N	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_5'UTR	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	67						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GGCCAAACTCGACAAAGCCCG	0.458000													62	584					0	0	0.048971	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110031576	110031576	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:110031576G>A	uc001dxr.2	+	7	906	c.891G>A	c.(889-891)GAG>GAA	p.E297E	ATXN7L2_uc001dxs.2_5'UTR|ATXN7L2_uc001dxt.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	297	SCA7.									ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTCCCAAGGAGAAGAGCCCAG	0.652000													12	268					0	0	0.010729	0	0
ZNF687	57592	broad.mit.edu	37	1	151259324	151259324	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:151259324G>A	uc001exq.2	+	2	655	c.557G>A	c.(556-558)CGG>CAG	p.R186Q	ZNF687_uc001exp.1_Missense_Mutation_p.R195Q|ZNF687_uc009wmo.2_Missense_Mutation_p.R186Q|ZNF687_uc009wmp.2_Missense_Mutation_p.R186Q	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	186	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCTCCCACTCGGGAGGGGGCT	0.622000													6	429					0	0	0.021553	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204416603	204416603	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:204416603C>T	uc001haw.2	-	16	2929	c.2450G>A	c.(2449-2451)CGC>CAC	p.R817H	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R817H	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	817					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TTTAAGCTTGCGCTGGTCTTC	0.557000													52	245					0	0	0.048971	0	0
LRRN2	10446	broad.mit.edu	37	1	204589069	204589069	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:204589069C>T	uc001hbe.1	-	3	440	c.52G>A	c.(52-54)GCC>ACC	p.A18T	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.A18T|LRRN2_uc009xbf.1_Missense_Mutation_p.A18T|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	18					cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GGCACAGCGGCAGTGGCACCA	0.647000													9	98					0	0	0.047766	0	0
USH2A	7399	broad.mit.edu	37	1	216144050	216144050	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:216144050G>A	uc001hku.1	-	36	7261	c.6874C>T	c.(6874-6876)CGT>TGT	p.R2292C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2292	Fibronectin type-III 9.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCGTAAGCACGATAGCTGAGT	0.418000										HNSCC(13;0.011)			6	433					0	0	0.021553	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													7	262					0	0	0.029380	0	0
MUC5B	727897	broad.mit.edu	37	11	1266085	1266085	+	Missense_Mutation	SNP	C	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:1266085C>G	uc009ycr.1	+	48	10015	c.9889C>G	c.(9889-9891)CCC>GCC	p.P3297A	MUC5B_uc001ltb.2_Missense_Mutation_p.P2662A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2659	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			P -> A (in Ref. 4; CAA96577).|Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCCACACCCCCACAGTGCT	0.562000													3	121					0	0	0.009096	0	0
DCHS1	8642	broad.mit.edu	37	11	6652947	6652947	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:6652947C>T	uc001mem.1	-	7	3985	c.3575G>A	c.(3574-3576)AGC>AAC	p.S1192N		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1192	Cadherin 11.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCTGTGGTGCTGCGGGGTGG	0.617000													5	93					0	0	0.021553	0	0
SLC6A5	9152	broad.mit.edu	37	11	20673951	20673951	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:20673951C>T	uc001mqd.2	+	15	2460	c.2187C>T	c.(2185-2187)ATC>ATT	p.I729I	SLC6A5_uc009yic.2_Silent_p.I494I	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	729	Helical; Name=12; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TCATCTGGATCCCAATTATGT	0.488000													25	770					0	0	0.024334	0	0
SVIP	258010	broad.mit.edu	37	11	22849412	22849412	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:22849412T>G	uc001mqp.3	-	2	151	c.63A>C	c.(61-63)AAA>AAC	p.K21N	uc001mqq.1_5'Flank	NM_148893	NP_683691	Q8NHG7	SVIP_HUMAN	small VCP/p97-interacting protein	21						Golgi membrane|plasma membrane|smooth endoplasmic reticulum membrane					0						GCTTTGCTCTTTTCTCTTCCT	0.259000													12	221					0	0	0.016723	0	0
AMBRA1	55626	broad.mit.edu	37	11	46568662	46568662	+	Splice_Site	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:46568662C>T	uc010rgu.1	-	4	738	c.378_splice	c.e4+1	p.H126_splice	AMBRA1_uc009ylc.1_Splice_Site_p.H126_splice|AMBRA1_uc001ncu.1_Splice_Site_p.H126_splice|AMBRA1_uc001ncv.2_Splice_Site_p.H126_splice|AMBRA1_uc001ncw.2_Splice_Site_p.H126_splice|AMBRA1_uc001ncx.2_Splice_Site_p.H126_splice	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated						autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GAAATACTCACGTGTAAATCC	0.323000													6	347					0	0	0.029380	0	0
SPTBN2	6712	broad.mit.edu	37	11	66454976	66454976	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:66454976G>A	uc001ojd.2	-	34	6716	c.6644C>T	c.(6643-6645)CCA>CTA	p.P2215L	SPTBN2_uc001ojc.1_Missense_Mutation_p.H76Y	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	2215					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTGGGCAGATGGCTCTGGGCC	0.667000													56	506					0	0	0.048971	0	0
YAP1	10413	broad.mit.edu	37	11	101984938	101984938	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr11:101984938C>T	uc001pgt.2	+	2	755	c.385C>T	c.(385-387)CCA>TCA	p.P129S	YAP1_uc001pgs.2_Missense_Mutation_p.P129S|YAP1_uc001pgu.2_Missense_Mutation_p.P129S|YAP1_uc001pgv.2_Missense_Mutation_p.P129S|YAP1_uc010ruo.1_5'UTR|YAP1_uc001pgw.2_5'UTR	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	129				P->D: No effect on phosphorylation but loss of interaction with YWHAB.	cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		TCATTCCTCTCCAGCTTCTCT	0.507000													10	295					0	0	0.058154	0	0
PTPRO	5800	broad.mit.edu	37	12	15673188	15673188	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:15673188G>A	uc001rcv.1	+	10	2007	c.1833G>A	c.(1831-1833)GTG>GTA	p.V611V	PTPRO_uc001rcw.1_Silent_p.V611V	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	611	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				TTACCATGGTGACGTGGGGAG	0.483000													121	463					0	0	0.048971	0	0
PTPRO	5800	broad.mit.edu	37	12	15673198	15673198	+	Missense_Mutation	SNP	G	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:15673198G>C	uc001rcv.1	+	10	2017	c.1843G>C	c.(1843-1845)GAT>CAT	p.D615H	PTPRO_uc001rcw.1_Missense_Mutation_p.D615H	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	615	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GACGTGGGGAGATCCAGAATT	0.478000													107	452					0	0	0.048971	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	rs121913529		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			21	117					0	0	0.062417	0	0
COL2A1	1280	broad.mit.edu	37	12	48372412	48372412	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:48372412C>T	uc001rqu.2	-	42	3044	c.2863G>A	c.(2863-2865)GAG>AAG	p.E955K	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.E886K	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	955	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCTCCCTTCTCGCCAGGGGGT	0.637000													24	241					0	0	0.016522	0	0
KRT7	3855	broad.mit.edu	37	12	52639214	52639214	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:52639214G>A	uc001saa.1	+	7	1130	c.1003G>A	c.(1003-1005)GCC>ACC	p.A335T	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	335	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GTTGGAGGCCGCCATTGCCGA	0.657000													4	134					0	0	0.009096	0	0
AVIL	10677	broad.mit.edu	37	12	58207947	58207947	+	Silent	SNP	G	A	A	rs141365699		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:58207947G>A	uc001sqj.1	-	2	158	c.129C>T	c.(127-129)TAC>TAT	p.Y43Y	AVIL_uc009zqe.1_Silent_p.Y36Y|AVIL_uc001sql.3_Silent_p.Y20Y	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	43	Gelsolin-like 1.|Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					AGAGGATGACGTAGCAGTCCC	0.607000													8	111					0	0	0.047766	0	0
CPM	1368	broad.mit.edu	37	12	69260780	69260780	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:69260780G>A	uc001sup.2	-	7	897	c.836C>T	c.(835-837)ACG>ATG	p.T279M	CPM_uc001sur.2_Missense_Mutation_p.T279M|CPM_uc001suq.2_Missense_Mutation_p.T279M	NM_198320	NP_938079	P14384	CBPM_HUMAN	carboxypeptidase M precursor	279					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding				0	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CAGCTCCAACGTAATTTCAAA	0.383000													50	404					0	0	0.048971	0	0
POLR3B	55703	broad.mit.edu	37	12	106820987	106820987	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:106820987C>T	uc001tlp.2	+	13	1336	c.1114C>T	c.(1114-1116)CTT>TTT	p.L372F	POLR3B_uc001tlq.2_Missense_Mutation_p.L314F	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	372					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TTTATCTCTTCTTTTTGAAGA	0.274000													13	85					0	0	0.049695	0	0
ATP2A2	488	broad.mit.edu	37	12	110765385	110765385	+	Missense_Mutation	SNP	A	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:110765385A>G	uc001tqk.3	+	8	1221	c.658A>G	c.(658-660)ATG>GTG	p.M220V	ATP2A2_uc001tql.3_Missense_Mutation_p.M220V|ATP2A2_uc010sxy.1_Missense_Mutation_p.M193V	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	220	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TGGGAAAGCTATGGGAGTGGT	0.463000													30	844					0	0	0.050027	0	0
AACS	65985	broad.mit.edu	37	12	125612743	125612743	+	Missense_Mutation	SNP	A	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr12:125612743A>C	uc001uhc.2	+	13	1552	c.1346A>C	c.(1345-1347)AAT>ACT	p.N449T	AACS_uc001uhd.2_Missense_Mutation_p.N449T|AACS_uc009zyh.2_Intron|AACS_uc009zyi.2_Missense_Mutation_p.N47T	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	449					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		ATGGGCCACAATTTTTCTCTT	0.493000													24	133					0	0	0.024334	0	0
COG3	83548	broad.mit.edu	37	13	46066374	46066374	+	Silent	SNP	A	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr13:46066374A>T	uc001vak.2	+	11	1277	c.1176A>T	c.(1174-1176)ACA>ACT	p.T392T	COG3_uc001vai.2_Silent_p.T392T|COG3_uc001vaj.1_Silent_p.T392T|COG3_uc010tfv.1_Silent_p.T229T|COG3_uc010aci.2_Silent_p.T168T	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	392					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CAAAACCAACATCAAAATTAG	0.353000													15	158					0	0	0.028581	0	0
FAM10A4	145165	broad.mit.edu	37	13	50746695	50746695	+	Silent	SNP	A	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr13:50746695A>G	uc001vej.2	+	1	542	c.471A>G	c.(469-471)TTA>TTG	p.L157L	DLEU1_uc010adl.1_Intron|DLEU1_uc001vee.1_Intron|DLEU1_uc010adm.1_Intron|DLEU1_uc010adn.1_Intron|DLEU1_uc001vef.1_Intron|DLEU1_uc001veg.1_Intron|DLEU1_uc010tgn.1_Intron|DLEU1_uc001vei.1_Intron|DLEU1_uc010ado.1_Intron|DLEU1_uc010adp.1_Intron	NR_002183				SubName: Full=ST13 protein;												0						TCGTCAAATTACAGAAGCCAA	0.478000													30	680					0	0	0.045705	0	0
PCDH17	27253	broad.mit.edu	37	13	58208534	58208534	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr13:58208534C>T	uc001vhq.1	+	1	2746	c.1854C>T	c.(1852-1854)GGC>GGT	p.G618G	PCDH17_uc010aec.1_Silent_p.G618G	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	618	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCGACTTCGGCGAGAGCGGGC	0.657000													8	451					0	0	0.038147	0	0
DCT	1638	broad.mit.edu	37	13	95095781	95095781	+	Nonsense_Mutation	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr13:95095781G>T	uc001vlv.3	-	7	1717	c.1290C>A	c.(1288-1290)TAC>TAA	p.Y430*	DCT_uc010afh.2_Nonsense_Mutation_p.Y463*	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	430	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		GAACCATGTTGTACATCCGAT	0.463000													33	245					1.71298e-08	1.77584e-08	0.064281	1	0
FLRT2	23768	broad.mit.edu	37	14	86089264	86089264	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr14:86089264G>A	uc001xvr.2	+	2	2173	c.1406G>A	c.(1405-1407)CGC>CAC	p.R469H	FLRT2_uc010atd.2_Missense_Mutation_p.R469H	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	469	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTTCAGGAGCGCATAGTCAGC	0.507000													9	559					0	0	0.047766	0	0
ASB2	51676	broad.mit.edu	37	14	94405527	94405527	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr14:94405527T>G	uc001ycc.1	-	6	1889	c.1400A>C	c.(1399-1401)CAC>CCC	p.H467P	ASB2_uc001ycb.1_Missense_Mutation_p.H161P|ASB2_uc001ycd.2_Missense_Mutation_p.H515P|ASB2_uc001yce.1_Missense_Mutation_p.H413P	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	467					intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		GGCCGGCGGGTGCGGGCCGTT	0.692000													9	47					0	0	0.048971	0	0
ADAM6	8755	broad.mit.edu	37	14	107062359	107062359	+	RNA	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr14:107062359G>T	uc010tyt.1	-	131		c.6236C>A								Parts of antibodies, mostly variable regions.												0						AGACAGCGCAGATGAGGGACA	0.607000													6	214					2.68362e-12	2.8341e-12	0.013537	1	0
MEX3B	84206	broad.mit.edu	37	15	82335639	82335639	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr15:82335639G>A	uc002bgq.1	-	2	1887	c.1572C>T	c.(1570-1572)AGC>AGT	p.S524S		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	524	RING-type.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						CAATCACTTCGCTCTCGAAGC	0.493000													21	394					0	0	0.062417	0	0
SEPT12	124404	broad.mit.edu	37	16	4836091	4836091	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr16:4836091C>T	uc002cxq.2	-	3	323	c.182G>A	c.(181-183)GGC>GAC	p.G61D	SEPT12_uc002cxr.2_Missense_Mutation_p.G61D|SEPT12_uc010bty.2_RNA|uc002cxt.2_5'Flank	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	61	GTP (By similarity).				cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						CGTGGACTTGCCCAGCCCGCT	0.517000													16	172					0	0	0.049695	0	0
SMG1	23049	broad.mit.edu	37	16	18896929	18896929	+	Silent	SNP	A	G	G	rs140363576	by1000genomes	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr16:18896929A>G	uc002dfm.2	-	7	1245	c.882T>C	c.(880-882)TGT>TGC	p.C294C	SMG1_uc010bwb.2_Silent_p.C154C	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	294	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TAACACATTTACAAAGCAATT	0.373000													5	320					0	0	0.029380	0	0
APOB48R	55911	broad.mit.edu	37	16	28509280	28509280	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr16:28509280G>A	uc002dqb.1	+	3	2901	c.2891G>A	c.(2890-2892)GGC>GAC	p.G964D	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.G502D	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	964					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GAGGCCATGGGCAGTGCCAGA	0.672000													29	181					0	0	0.034045	0	0
CDYL2	124359	broad.mit.edu	37	16	80667060	80667060	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr16:80667060G>A	uc002ffs.2	-	3	795	c.690C>T	c.(688-690)TAC>TAT	p.Y230Y		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	230						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						TGTCAAAGACGTAGTCCTTCT	0.502000													22	650					0	0	0.014323	0	0
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr17:7578413C>G	uc002gim.2	-	5	711	c.517G>C	c.(517-519)GTG>CTG	p.V173L	TP53_uc002gig.1_Missense_Mutation_p.V173L|TP53_uc002gih.2_Missense_Mutation_p.V173L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41L|TP53_uc010cng.1_Missense_Mutation_p.V41L|TP53_uc002gii.1_Missense_Mutation_p.V41L|TP53_uc010cnh.1_Missense_Mutation_p.V173L|TP53_uc010cni.1_Missense_Mutation_p.V173L|TP53_uc002gij.2_Missense_Mutation_p.V173L|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80L|TP53_uc002gio.2_Missense_Mutation_p.V41L|TP53_uc010vug.1_Missense_Mutation_p.V134L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	239					0	0	0.059317	0	0
C17orf101	79701	broad.mit.edu	37	17	80361874	80361874	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr17:80361874C>T	uc002keu.1	-	7	739	c.638G>A	c.(637-639)CGC>CAC	p.R213H	C17orf101_uc002ket.1_Missense_Mutation_p.R213H|C17orf101_uc010dip.1_RNA	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	213	Fe2OG dioxygenase.|Lumenal (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						GCTGTTTATGCGGGAGAAGAA	0.642000													3	46					0	0	0.004672	0	0
CD209	30835	broad.mit.edu	37	19	7810584	7810584	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:7810584G>A	uc002mht.2	-	4	635	c.568C>T	c.(568-570)CAG>TAG	p.Q190*	CD209_uc010xju.1_Intron|CD209_uc010dvp.2_Nonsense_Mutation_p.Q166*|CD209_uc002mhr.2_Nonsense_Mutation_p.Q166*|CD209_uc002mhs.2_Nonsense_Mutation_p.Q166*|CD209_uc002mhu.2_Intron|CD209_uc010dvq.2_Nonsense_Mutation_p.Q190*|CD209_uc002mhq.2_Nonsense_Mutation_p.Q190*|CD209_uc002mhv.2_Nonsense_Mutation_p.Q166*|CD209_uc002mhx.2_Nonsense_Mutation_p.Q146*|CD209_uc002mhw.2_Intron|CD209_uc010dvr.2_Intron	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	190	Extracellular (Probable).|5.|7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						TAGATCTCCTGCTGCTTAGAT	0.547000													32	616					0	0	0.021022	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010294	24010294	+	Missense_Mutation	SNP	C	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:24010294C>G	uc002nrn.2	+	4	754	c.331C>G	c.(331-333)CAG>GAG	p.Q111E		NM_002295	NP_002286			ribosomal protein SA												0						CTTCACTAACCAGATCCAGGC	0.567000													6	216					0	0	0.058154	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316442	40316442	+	Silent	SNP	T	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:40316442T>G	uc002omj.2	-	11	2083	c.1803A>C	c.(1801-1803)CCA>CCC	p.P601P	DYRK1B_uc002omi.2_Silent_p.P573P|DYRK1B_uc002omk.2_Silent_p.P561P	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	601					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GCGGGAGGGGTGGACGACCTC	0.716000													8	55					0	0	0.013537	0	0
PSG6	5675	broad.mit.edu	37	19	43411981	43411981	+	Silent	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:43411981G>T	uc002ovj.1	-	4	784	c.732C>A	c.(730-732)ACC>ACA	p.T244T	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Silent_p.T251T|PSG6_uc002ovi.2_Silent_p.T245T|PSG6_uc010xwk.1_Silent_p.T84T|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Silent_p.T34T|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Silent_p.T244T	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	244	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				AGTTGTTGATGGTGATGTAAG	0.478000													81	814					4.01556e-35	4.49266e-35	0.048971	1	0
CNOT3	4849	broad.mit.edu	37	19	54646728	54646728	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:54646728G>A	uc002qdj.1	+	2	325	c.14G>A	c.(13-15)CGC>CAC	p.R5H	CNOT3_uc010yel.1_Missense_Mutation_p.R5H|CNOT3_uc002qdi.2_5'UTR|CNOT3_uc002qdk.1_Missense_Mutation_p.R5H|CNOT3_uc010ere.1_5'Flank	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	5					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCGGACAAGCGCAAACTCCAA	0.527000													8	536					0	0	0.047766	0	0
ZNF784	147808	broad.mit.edu	37	19	56133798	56133798	+	Silent	SNP	A	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:56133798A>C	uc002qll.1	-	2	305	c.291T>G	c.(289-291)GGT>GGG	p.G97G	ZNF784_uc010etb.1_RNA	NM_203374	NP_976308	Q8NCA9	ZN784_HUMAN	zinc finger protein 784	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		TCGGGTCCCCACCCTGCCCGC	0.711000													6	57					0	0	0.047766	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:58385762C>G	uc002qqo.2	-	3	1268	c.996G>C	c.(994-996)TCG>TCC	p.S332S	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332	C2H2-type 5.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						ATTTGCTAAACGATTTCCCAC	0.358000													4	35					0	0	0.014758	0	0
TTN	7273	broad.mit.edu	37	2	179576918	179576918	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:179576918C>T	uc010zfg.1	-	93	24131	c.23907G>A	c.(23905-23907)CCG>CCA	p.P7969P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.P4630P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8896							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACCTTAACCGGCTCCAACT	0.443000													15	328					0	0	0.020292	0	0
TTN	7273	broad.mit.edu	37	2	179643640	179643640	+	Missense_Mutation	SNP	G	A	A	rs144011561		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:179643640G>A	uc010zfg.1	-	24	4393	c.4169C>T	c.(4168-4170)CCG>CTG	p.P1390L	TTN_uc010zfh.1_Missense_Mutation_p.P1344L|TTN_uc010zfi.1_Missense_Mutation_p.P1344L|TTN_uc010zfj.1_Missense_Mutation_p.P1344L|TTN_uc002unb.2_Missense_Mutation_p.P1390L|uc002unc.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1390							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATGTAAGTCGGAGCTCCAAG	0.388000													17	318					0	0	0.033300	0	0
CPS1	1373	broad.mit.edu	37	2	211532923	211532923	+	Missense_Mutation	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:211532923G>T	uc002vee.3	+	34	4148	c.4016G>T	c.(4015-4017)GGT>GTT	p.G1339V	CPS1_uc010fur.2_Missense_Mutation_p.G1345V|CPS1_uc010fus.2_Missense_Mutation_p.G888V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1339					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GCTTGCTTTGGTGAAGGTATT	0.353000													26	366					2.44723e-14	2.60884e-14	0.024334	1	0
FERMT1	55612	broad.mit.edu	37	20	6093196	6093196	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr20:6093196T>G	uc002wmr.2	-	4	1249	c.460A>C	c.(460-462)AAA>CAA	p.K154Q	FERMT1_uc010gbt.2_5'UTR|FERMT1_uc002wms.2_Missense_Mutation_p.K154Q	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	154	Poly-Lys.|FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						TTATTATTTTTGTCTTTTTTC	0.318000													26	526					0	0	0.021523	0	0
TTLL9	164395	broad.mit.edu	37	20	30526969	30526969	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr20:30526969C>T	uc010gdx.1	+	14	1396	c.1143C>T	c.(1141-1143)GTC>GTT	p.V381V	TTLL9_uc002wwy.1_RNA|TTLL9_uc002wwz.1_Intron|TTLL9_uc002wxa.1_RNA|TTLL9_uc002wxb.1_RNA|TTLL9_uc010zto.1_RNA|TTLL9_uc002wxc.2_Silent_p.V283V|TTLL9_uc010ztp.1_Intron|TTLL9_uc010ztq.1_RNA	NM_001008409	NP_001008409	Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	381					protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			ovary(2)	2			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGAAGCGAGTCGGGGGCTTTG	0.577000													43	395					0	0	0.048971	0	0
MN1	4330	broad.mit.edu	37	22	28194933	28194933	+	Silent	SNP	T	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr22:28194933T>C	uc003adj.2	-	1	2554	c.1599A>G	c.(1597-1599)CAA>CAG	p.Q533Q		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	533	Poly-Gln.						binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						gctgctgctgttgctgctgct	0.388000			T	ETV6	AML|meningioma								3	43					0	0	0.004672	0	0
MST1	4485	broad.mit.edu	37	3	49723522	49723522	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr3:49723522G>A	uc003cxg.2	-	9	1192	c.1120C>T	c.(1120-1122)CGT>TGT	p.R374C	MST1_uc011bcs.1_Silent_p.G412G|MST1_uc010hkx.2_3'UTR|MST1_uc011bct.1_3'UTR	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	360	Kringle 3.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTGTACAACGCCGGATCTGG	0.697000													7	115					0	0	0.010729	0	0
NISCH	11188	broad.mit.edu	37	3	52505887	52505887	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr3:52505887C>T	uc011beg.1	+	6	539	c.467C>T	c.(466-468)GCC>GTC	p.A156V	NISCH_uc003ded.3_Missense_Mutation_p.A156V|NISCH_uc003dec.1_Missense_Mutation_p.A156V	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	156	Necessary for homooligomerization and targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CAGCTGTATGCCGTCACGGAG	0.627000											OREG0015615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	318					0	0	0.021553	0	0
LRRC33	375387	broad.mit.edu	37	3	196387199	196387199	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr3:196387199C>T	uc003fwv.2	+	3	789	c.685C>T	c.(685-687)CGG>TGG	p.R229W		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	229	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CACGCGGCTGCGGGTCCTCAA	0.647000													13	305					0	0	0.020292	0	0
OTOP1	133060	broad.mit.edu	37	4	4228226	4228226	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr4:4228226G>A	uc003ghp.1	-	1	396	c.366C>T	c.(364-366)CGC>CGT	p.R122R		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	122					biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGTCCTTGAGGCGGAAGAGGC	0.716000													3	88					0	0	0.009096	0	0
WDR1	9948	broad.mit.edu	37	4	10080533	10080533	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr4:10080533C>T	uc003gmf.2	-	12	1660	c.1377G>A	c.(1375-1377)ACG>ACA	p.T459T	WDR1_uc003gmg.2_Silent_p.T319T|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	459	WD 8.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CAATTGCCACCGTGTCCCCGC	0.592000													5	259					0	0	0.021553	0	0
NPY2R	4887	broad.mit.edu	37	4	156135813	156135813	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr4:156135813G>A	uc003ioq.2	+	2	1217	c.722G>A	c.(721-723)CGC>CAC	p.R241H	NPY2R_uc003ior.2_Missense_Mutation_p.R241H	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	241	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				TCCTACACTCGCATTTGGAGT	0.448000													8	344					0	0	0.038147	0	0
RAD17	5884	broad.mit.edu	37	5	68669707	68669707	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr5:68669707C>T	uc003jwo.2	+	2	155	c.93C>T	c.(91-93)GGC>GGT	p.G31G	RAD17_uc003jwg.2_Silent_p.G20G|RAD17_uc003jwh.2_Silent_p.G20G|RAD17_uc003jwi.2_Silent_p.G20G|RAD17_uc003jwj.2_Silent_p.G20G|RAD17_uc003jwk.2_Silent_p.G20G|RAD17_uc003jwl.2_Silent_p.G20G|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Intron	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	31					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		AGTGTAGTGGCGTCTCTACTA	0.363000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					47	324					0	0	0.048971	0	0
GRM6	2916	broad.mit.edu	37	5	178413312	178413312	+	Missense_Mutation	SNP	G	A	A	rs61733863	byFrequency	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr5:178413312G>A	uc003mjr.2	-	8	2122	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	GRM6_uc003mjq.2_5'Flank|GRM6_uc010jla.1_Missense_Mutation_p.A231V|GRM6_uc003mjs.1_Missense_Mutation_p.A268V	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	648	Extracellular (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGCACAGACCGCGGCCCCAGG	0.642000													7	142					0	0	0.029380	0	0
ENPP5	59084	broad.mit.edu	37	6	46129388	46129388	+	Missense_Mutation	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:46129388G>T	uc003oxz.1	-	4	1317	c.1109C>A	c.(1108-1110)TCC>TAC	p.S370Y	ENPP5_uc003oya.1_Missense_Mutation_p.S370Y|ENPP5_uc011dvz.1_Missense_Mutation_p.S276Y|ENPP5_uc010jzc.1_3'UTR	NM_021572	NP_067547	Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	370						extracellular region|integral to membrane	hydrolase activity				0						CAAATCTGTGGAGTTCATGGC	0.448000													33	892					7.26314e-15	7.81652e-15	0.034045	1	0
C6orf138	442213	broad.mit.edu	37	6	47847402	47847402	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:47847402G>A	uc011dwm.1	-	3	1212	c.1127C>T	c.(1126-1128)GCT>GTT	p.A376V	C6orf138_uc011dwn.1_Missense_Mutation_p.A140V	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	393	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TAGTTGGCCAGCAAAGACCAG	0.453000													4	153					0	0	0.009096	0	0
RNGTT	8732	broad.mit.edu	37	6	89388128	89388128	+	Missense_Mutation	SNP	G	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:89388128G>C	uc003pmr.2	-	14	1670	c.1450C>G	c.(1450-1452)CAG>GAG	p.Q484E	RNGTT_uc003pms.2_Missense_Mutation_p.Q461E|RNGTT_uc011dzu.1_Missense_Mutation_p.Q401E|RNGTT_uc003pmt.2_Missense_Mutation_p.Q484E	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	484	GTase.			Q -> P (in Ref. 1; AAB91559).	interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		CCAACATTCTGAGGAAGTAAC	0.279000													6	164					0	0	0.021553	0	0
SHPRH	257218	broad.mit.edu	37	6	146207836	146207836	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:146207836C>T	uc003qlf.2	-	30	5442	c.5043G>A	c.(5041-5043)GAG>GAA	p.E1681E	SHPRH_uc003qld.2_Silent_p.E1685E|SHPRH_uc003qle.2_Intron	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1681					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TTCATTCAAGCTCTTCAGTTT	0.398000													6	215					0	0	0.029380	0	0
SYNE1	23345	broad.mit.edu	37	6	152469332	152469332	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:152469332G>A	uc010kiw.2	-	137	25426	c.24824C>T	c.(24823-24825)CCG>CTG	p.P8275L	SYNE1_uc010kiv.2_Missense_Mutation_p.P2799L|SYNE1_uc003qos.3_Missense_Mutation_p.P2799L|SYNE1_uc003qot.3_Missense_Mutation_p.P8204L|SYNE1_uc003qou.3_Missense_Mutation_p.P8275L|SYNE1_uc003qop.3_Missense_Mutation_p.P437L|SYNE1_uc011eez.1_Missense_Mutation_p.P477L|SYNE1_uc003qoq.3_Missense_Mutation_p.P477L|SYNE1_uc003qor.3_Missense_Mutation_p.P1175L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8275	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CACACTAGCCGGGGTGTCTCG	0.617000										HNSCC(10;0.0054)			6	253					0	0	0.021553	0	0
SDK1	221935	broad.mit.edu	37	7	4153009	4153009	+	Missense_Mutation	SNP	G	A	A	rs149058628	byFrequency	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:4153009G>A	uc003smx.2	+	24	3662	c.3523G>A	c.(3523-3525)GTG>ATG	p.V1175M	SDK1_uc010kso.2_Missense_Mutation_p.V451M	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1175	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCACCCGACGTGGCTCCAAC	0.612000													200	689					0	0	0.048971	0	0
OCM	654231	broad.mit.edu	37	7	5923595	5923595	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:5923595C>T	uc003spe.3	+	3	361	c.269C>T	c.(268-270)GCG>GTG	p.A90V		NM_001097622	NP_001091091	P0CE72	ONCO_HUMAN	oncomodulin	90	EF-hand 2.						calcium ion binding				0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0978)|OV - Ovarian serous cystadenocarcinoma(56;2.11e-14)		ATGGCTGCGGCGGATAATGAT	0.498000													7	129					0	0	0.038147	0	0
GLI3	2737	broad.mit.edu	37	7	42005706	42005706	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:42005706G>A	uc011kbh.1	-	15	3056	c.2965C>T	c.(2965-2967)CGG>TGG	p.R989W	GLI3_uc011kbg.1_Missense_Mutation_p.R930W	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	989					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						AGGTGGCGCCGCCCGTAGCCG	0.766000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				12	60					0	0	0.010729	0	0
HECW1	23072	broad.mit.edu	37	7	43540839	43540839	+	Silent	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:43540839C>T	uc003tid.1	+	21	4154	c.3549C>T	c.(3547-3549)TAC>TAT	p.Y1183Y	HECW1_uc011kbi.1_Silent_p.Y1149Y	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1183					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TTATGTCCTACGTCCCCCTGC	0.423000													46	379					0	0	0.042209	0	0
Unknown	0	broad.mit.edu	37	7	64498737	64498737	+	RNA	SNP	C	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:64498737C>A	uc003ttt.1	+	1		c.6C>A			uc010kzt.1_RNA					Homo sapiens cDNA clone IMAGE:4215179, partial cds.																		gaggcggtggcggcggcggca	0.343000													8	62					9.70103e-10	1.01501e-09	0.008291	1	0
SPDYE7P	441251	broad.mit.edu	37	7	72338030	72338030	+	RNA	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:72338030G>A	uc010lal.1	-	1		c.1626C>T				NR_003666				Homo sapiens speedy homolog E7 (Xenopus laevis), pseudogene (SPDYE7P), non-coding RNA.												0						acttgaacccgggaggcatcg	0.005000													3	33					0	0	0.009096	0	0
LOC100132832	100132832	broad.mit.edu	37	7	76681226	76681226	+	RNA	SNP	G	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:76681226G>C	uc003ufy.2	+	5		c.1203G>C				NR_028058				Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0						TGTCACACTTGAAGGAGGCAG	0.453000													5	31					0	0	0.058154	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22960677	22960677	+	Missense_Mutation	SNP	G	A	A	rs147367612	byFrequency	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr8:22960677G>A	uc003xcy.2	+	1	244	c.43G>A	c.(43-45)GTC>ATC	p.V15I	TNFRSF10C_uc003xcx.2_RNA|TNFRSF10C_uc011kzr.1_RNA	NM_003841	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily,	15					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		CGTCGTCATCGTCGCGGTCCT	0.701000													6	60					0	0	0.021553	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr9:20414373G>A	uc003zoe.2	-	5	730	c.471C>T	c.(469-471)AGC>AGT	p.S157S	MLLT3_uc011lne.1_Silent_p.S125S|MLLT3_uc011lnf.1_Silent_p.S154S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Intron	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.134000			T	MLL	ALL								5	211					0	0	0.029380	0	0
GNE	10020	broad.mit.edu	37	9	36217507	36217507	+	Missense_Mutation	SNP	T	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr9:36217507T>C	uc010mlh.2	-	12	2239	c.2024A>G	c.(2023-2025)TAT>TGT	p.Y675C	CLTA_uc003zzf.1_Intron|GNE_uc010mlg.2_Missense_Mutation_p.Y601C|GNE_uc011lpl.1_Missense_Mutation_p.Y565C|GNE_uc010mli.2_Missense_Mutation_p.Y706C|GNE_uc010mlj.2_Missense_Mutation_p.Y670C	NM_005476	NP_005467	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	675	UDP-N-acetylglucosamine 2-epimerase.|N-acetylmannosamine kinase.		Y -> H (in IBM2).		cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			AATGTGGATATAGTGACTGGC	0.552000													8	229					0	0	0.047766	0	0
ZNF618	114991	broad.mit.edu	37	9	116812071	116812071	+	Missense_Mutation	SNP	G	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr9:116812071G>T	uc004bid.2	+	15	2588	c.2489G>T	c.(2488-2490)TGT>TTT	p.C830F	ZNF618_uc004bic.2_Missense_Mutation_p.C737F|ZNF618_uc011lxi.1_Missense_Mutation_p.C797F|ZNF618_uc011lxj.1_Missense_Mutation_p.C798F|ZNF618_uc010mvb.2_Missense_Mutation_p.C420F	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	830					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCAAGGTCTGTGAGCTCATC	0.652000													57	251					4.96213e-28	5.49727e-28	0.048971	1	0
BCOR	54880	broad.mit.edu	37	X	39933048	39933048	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:39933048G>A	uc004den.3	-	4	1843	c.1551C>T	c.(1549-1551)AAC>AAT	p.N517N	BCOR_uc004dep.3_Silent_p.N517N|BCOR_uc004deo.3_Silent_p.N517N|BCOR_uc004dem.3_Silent_p.N517N|BCOR_uc004deq.3_Silent_p.N517N	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	517					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						TGTTCTCTTCGTTAGGACTTG	0.527000													11	330					0	0	0.008291	0	0
PCSK1N	27344	broad.mit.edu	37	X	48690597	48690597	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:48690597C>T	uc004dkz.2	-	2	295	c.269G>A	c.(268-270)CGG>CAG	p.R90Q		NM_013271	NP_037403	Q9UHG2	PCSK1_HUMAN	proprotein convertase subtilisin/kexin type 1	90	ProSAAS(1-180) (By similarity).				neuropeptide signaling pathway	extracellular space|soluble fraction	receptor binding				0						GGCCCGCGCCCGCTCCTGACG	0.766000													3	40					0	0	0.009096	0	0
MED12	9968	broad.mit.edu	37	X	70356862	70356862	+	Missense_Mutation	SNP	A	C	C			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:70356862A>C	uc004dyy.2	+	38	5733	c.5534A>C	c.(5533-5535)AAC>ACC	p.N1845T	MED12_uc011mpq.1_Missense_Mutation_p.N1845T|MED12_uc004dyz.2_Missense_Mutation_p.N1845T|MED12_uc004dza.2_Missense_Mutation_p.N1692T|MED12_uc010nla.2_Missense_Mutation_p.N471T	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1845	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TACACCCAGAACCAGCCACTA	0.567000													15	60					0	0	0.024334	0	0
MAGT1	84061	broad.mit.edu	37	X	77112307	77112307	+	Missense_Mutation	SNP	T	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:77112307T>A	uc004fof.2	-	5	753	c.691A>T	c.(691-693)ATT>TTT	p.I231F	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	199	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						AGTCCACCAATAACAGCCAAA	0.363000													34	482					0	0	0.054565	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299463	125299463	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:125299463C>T	uc004euk.1	-	1	472	c.445G>A	c.(445-447)GGC>AGC	p.G149S		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	149	WD 1.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATGCCGCAGCCCTGGTGGGCC	0.642000													9	858					0	0	0.058154	0	0
GPC4	2239	broad.mit.edu	37	X	132458560	132458560	+	Silent	SNP	G	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:132458560G>A	uc004exc.1	-	3	536	c.324C>T	c.(322-324)TTC>TTT	p.F108F	GPC4_uc011mvg.1_Silent_p.F38F	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	108					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GTTCTTTGAAGAATTCTGAAA	0.284000													26	492					0	0	0.059317	0	0
EPS8L3	79574	broad.mit.edu	37	1	110300579	110300580	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr1:110300579_110300580insT	uc001dyr.1	-	9	963_964	c.818_819insA	c.(817-819)AACfs	p.N273fs	EPS8L3_uc001dys.1_Frame_Shift_Ins_p.N273fs|EPS8L3_uc001dyq.1_Frame_Shift_Ins_p.N274fs|EPS8L3_uc009wfm.1_Frame_Shift_Ins_p.N240fs|EPS8L3_uc009wfn.1_Frame_Shift_Ins_p.N248fs|EPS8L3_uc009wfo.1_Frame_Shift_Ins_p.N220fs	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	273						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CCTGGTCCTTGTTTTTTTTCCC	0.545													7	863	---	---	---	---					
LYZL1	84569	broad.mit.edu	37	10	29599965	29599965	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr10:29599965delA	uc001iul.2	+	5	619	c.562delA	c.(562-564)AAAfs	p.K188fs		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	142					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				GTCCGAGTGGAAAAAAGGCTG	0.512													7	1022	---	---	---	---					
PCDH15	65217	broad.mit.edu	37	10	55582841	55582842	+	Frame_Shift_Ins	INS	-	A	A			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr10:55582841_55582842insA	uc001jju.1	-	33	5039_5040	c.4644_4645insT	c.(4642-4647)TTTGTAfs	p.F1548fs	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Frame_Shift_Ins_p.F1545fs|PCDH15_uc010qhw.1_Frame_Shift_Ins_p.F1508fs|PCDH15_uc010qhx.1_Frame_Shift_Ins_p.F1479fs|PCDH15_uc010qhy.1_Frame_Shift_Ins_p.F1555fs|PCDH15_uc010qhz.1_Frame_Shift_Ins_p.F1550fs|PCDH15_uc010qia.1_Frame_Shift_Ins_p.F1528fs|PCDH15_uc010qib.1_Frame_Shift_Ins_p.F1525fs	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1548_1549	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AATGGGTCTACAAAATCTGTTC	0.411										HNSCC(58;0.16)			61	752	---	---	---	---					
MKI67	4288	broad.mit.edu	37	10	129904534	129904535	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr10:129904534_129904535insT	uc001lke.2	-	13	5764_5765	c.5569_5570insA	c.(5569-5571)ATAfs	p.I1857fs	MKI67_uc001lkf.2_Frame_Shift_Ins_p.I1497fs|MKI67_uc009yav.1_Frame_Shift_Ins_p.I1432fs|MKI67_uc009yaw.1_Frame_Shift_Ins_p.I1007fs	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1857	16 X 122 AA approximate repeats.|8.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTGCAGAGTATTTTTTTGGTA	0.480													7	1379	---	---	---	---					
USP36	57602	broad.mit.edu	37	17	76800004	76800004	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr17:76800004delT	uc002jvz.1	-	16	2598	c.2273delA	c.(2272-2274)CACfs	p.H758fs	USP36_uc002jwa.1_Frame_Shift_Del_p.H758fs|USP36_uc002jwb.1_Intron|USP36_uc002jwc.1_Frame_Shift_Del_p.H458fs|USP36_uc002jvy.1_5'Flank	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	758					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CAATGTGGGGTGGGGGCTGAA	0.627													7	341	---	---	---	---					
GRIN3B	116444	broad.mit.edu	37	19	1009186	1009188	+	In_Frame_Del	DEL	AGC	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:1009186_1009188delAGC	uc002lqo.1	+	9	2717_2719	c.2717_2719delAGC	c.(2716-2721)GAGCAG>GAG	p.Q912del	uc002lqp.1_RNA	NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	912	Cytoplasmic (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCCGAGGTGGagcagcagcagca	0.680													8	11	---	---	---	---					
PLEKHA4	57664	broad.mit.edu	37	19	49355519	49355530	+	In_Frame_Del	DEL	GTCTCTCTTAAG	-	-	rs147150671	byFrequency	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr19:49355519_49355530delGTCTCTCTTAAG	uc002pkx.2	-	13	1931_1942	c.1380_1391delCTTAAGAGAGAC	c.(1378-1392)ACCTTAAGAGAGACG>ACG	p.460_464TLRET>T	PLEKHA4_uc002pkw.1_5'UTR|PLEKHA4_uc010eml.2_In_Frame_Del_p.435_439TLRET>T	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	460_464						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GTACTCCAGCGTCTCTCTTAAGGTGCCCAGCT	0.566													22	464	---	---	---	---					
ALMS1	7840	broad.mit.edu	37	2	73613032	73613037	+	In_Frame_Del	DEL	GGAGGA	-	-	rs72319667		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:73613032_73613037delGGAGGA	uc002sje.1	+	1	147_152	c.36_41delGGAGGA	c.(34-42)CTGGAGGAG>CTG	p.EE27del	ALMS1_uc002sjf.1_In_Frame_Del_p.EE27del	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	27_28	Glu-rich.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CGGGCGAGCTggaggaggaggaggag	0.403													5	3	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	95558422	95558423	+	RNA	INS	-	T	T	rs5832787		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:95558422_95558423insT	uc002stv.1	-	6		c.578_579insA								Homo sapiens cDNA FLJ44118 fis, clone TESTI4047069.																		ATCTGGACCCCGTTTGCAATCT	0.475													7	66	---	---	---	---					
DUSP2	1844	broad.mit.edu	37	2	96809973	96809973	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:96809973delA	uc002svk.3	-	3	736	c.650delT	c.(649-651)TTCfs	p.F217fs		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	217					endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				CTTGTAGCGGAAAAGGCCCTC	0.602													7	598	---	---	---	---					
PLA2R1	22925	broad.mit.edu	37	2	160801441	160801442	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr2:160801441_160801442insT	uc002ube.1	-	28	4326_4327	c.4119_4120insA	c.(4117-4122)AAAGGCfs	p.K1373fs	PLA2R1_uc010zcp.1_Frame_Shift_Ins_p.K1371fs	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1373_1374	Extracellular (Potential).|C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CATATAAAGCCTTTTTTTTCTT	0.401													9	835	---	---	---	---					
SORBS2	8470	broad.mit.edu	37	4	186544620	186544622	+	In_Frame_Del	DEL	GGT	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr4:186544620_186544622delGGT	uc003iyl.2	-	13	2807_2809	c.1949_1951delACC	c.(1948-1953)CACCGC>CGC	p.H650del	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_In_Frame_Del_p.H750del|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_In_Frame_Del_p.H554del|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_In_Frame_Del_p.H764del|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	650	His-rich.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ATGAggtggcggtggtggtggtg	0.384													8	370	---	---	---	---					
ZNF318	24149	broad.mit.edu	37	6	43323502	43323502	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr6:43323502delT	uc003oux.2	-	4	1648	c.1570delA	c.(1570-1572)AGGfs	p.R524fs	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	524					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTACGTCGCCTTTTTTCCTGT	0.493													8	1769	---	---	---	---					
HOXA11	3207	broad.mit.edu	37	7	27222462	27222462	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:27222462delT	uc003syx.2	-	2	967	c.895delA	c.(895-897)ATTfs	p.I299fs	HOXA10_uc003syw.3_5'Flank|HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	299	Homeobox.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						TCTCTGTTAATTTTTTTTTCC	0.448			T	NUP98	CML								7	743	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	31148360	31148361	+	RNA	INS	-	TG	TG	rs146476306	by1000genomes	TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:31148360_31148361insTG	uc003tcg.2	+	1		c.919_920insTG								Homo sapiens cDNA FLJ39226 fis, clone OCBBF2007232.																		TGATGAATATAtgtgtgtgtgt	0.347													4	3	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	-	-	rs11277659		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr7:131241030_131241035delGGCGAC	uc003vqw.3	-	1	342_347	c.84_89delGTCGCC	c.(82-90)CCGTCGCCC>CCC	p.28_30PSP>P	PODXL_uc003vqx.3_In_Frame_Del_p.28_30PSP>P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	28_30	Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.573													7	11	---	---	---	---					
STAU2	27067	broad.mit.edu	37	8	74507471	74507471	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr8:74507471delT	uc003xzm.2	-	11	1327	c.1091delA	c.(1090-1092)AATfs	p.N364fs	STAU2_uc011lfg.1_Frame_Shift_Del_p.N192fs|STAU2_uc003xzn.2_Frame_Shift_Del_p.N332fs|STAU2_uc011lfh.1_Frame_Shift_Del_p.N260fs|STAU2_uc003xzo.2_Frame_Shift_Del_p.N364fs|STAU2_uc003xzp.2_Frame_Shift_Del_p.N332fs|STAU2_uc011lfi.1_Frame_Shift_Del_p.N326fs|STAU2_uc003xzq.2_Frame_Shift_Del_p.N144fs|STAU2_uc010lzk.2_Frame_Shift_Del_p.N332fs|STAU2_uc010lzl.1_Frame_Shift_Del_p.N192fs	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	364	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TTCTGCAGCATTTTTTTTGGC	0.328													10	494	---	---	---	---					
GRHPR	9380	broad.mit.edu	37	9	37424907	37424908	+	Frame_Shift_Ins	INS	-	G	G	rs150805048		TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chr9:37424907_37424908insG	uc003zzu.1	+	2	190_191	c.149_150insG	c.(148-150)GCGfs	p.A50fs	GRHPR_uc010mlu.2_5'UTR|GRHPR_uc010mlv.1_5'UTR|GRHPR_uc003zzt.1_5'UTR	NM_012203	NP_036335	Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	50					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding				0				GBM - Glioblastoma multiforme(29;0.00687)		CGAGGTGTGGCGGGGGCCCACG	0.658													10	330	---	---	---	---					
PLXNA3	55558	broad.mit.edu	37	X	153688565	153688565	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FZ-5919-01A-11D-1609-08	TCGA-FZ-5919-11A-02D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	82303e3b-eeef-43ac-8d4a-85794482fd12	157c9dc6-2898-426a-b99e-03583bbff508	g.chrX:153688565delG	uc004flm.2	+	2	215	c.42delG	c.(40-42)GTGfs	p.V14fs		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	14					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTTGCCGTGGGGGGGGCCC	0.682													8	690	---	---	---	---					
