Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MMEL1	79258	broad.mit.edu	37	1	2530110	2530110	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:2530110G>A	uc001ajy.2	-	12	1375	c.1161C>T	c.(1159-1161)ATC>ATT	p.I387I	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	387	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		AGTAGGTGTCGATGATGTTTT	0.542000													27	313					0	0	0.024334	0	0
UBR4	23352	broad.mit.edu	37	1	19455510	19455510	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:19455510G>A	uc001bbi.2	-	61	8969	c.8965C>T	c.(8965-8967)CGA>TGA	p.R2989*	UBR4_uc001bbk.1_Nonsense_Mutation_p.R636*	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2989					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCAACGTTTCGTAATTGAGGC	0.502000													23	433					0	0	0.016522	0	0
CSMD2	114784	broad.mit.edu	37	1	34209014	34209014	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:34209014G>A	uc001bxn.1	-	14	1949	c.1920C>T	c.(1918-1920)GCC>GCT	p.A640A	CSMD2_uc001bxm.1_Silent_p.A680A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	640	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CGGGCGCCTCGGCGGTGGCCC	0.612000													33	401					0	0	0.013726	0	0
C8A	731	broad.mit.edu	37	1	57378141	57378141	+	Missense_Mutation	SNP	C	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:57378141C>A	uc001cyo.2	+	10	1578	c.1446C>A	c.(1444-1446)AAC>AAA	p.N482K		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	482	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AGCGCCAGAACCTGCGCCGCG	0.622000													14	494					1.49906e-05	1.54449e-05	0.020292	1	0
HFM1	164045	broad.mit.edu	37	1	91851171	91851171	+	Missense_Mutation	SNP	G	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:91851171G>T	uc001doa.3	-	5	815	c.715C>A	c.(715-717)CCA>ACA	p.P239T	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Missense_Mutation_p.P239T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	239							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GAAAAAGATGGTGCTTTGAAC	0.338000													9	272					0.000442599	0.000451451	0.006214	1	0
SPAG17	200162	broad.mit.edu	37	1	118535130	118535130	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:118535130T>G	uc001ehk.2	-	36	5388	c.5320A>C	c.(5320-5322)ATA>CTA	p.I1774L		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1774						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCATTCTTTATGACCTCATGC	0.473000													13	547					0	0	0.020292	0	0
LCE1D	353134	broad.mit.edu	37	1	152770432	152770432	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:152770432C>T	uc009wnp.2	+	2	205	c.162C>T	c.(160-162)GGC>GGT	p.G54G		NM_178352	NP_848129	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	54	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm					0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGGGGGCGGCTGTGGCT	0.642000													41	495					0	0	0.039052	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:155887393T>G	uc001fmi.1	-	11	1361	c.1337A>C	c.(1336-1338)CAG>CCG	p.Q446P	KIAA0907_uc001fmj.1_Missense_Mutation_p.Q446P|KIAA0907_uc009wrk.1_Missense_Mutation_p.Q303P|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	446	Pro-rich.										0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.448000													12	111					0	0	0.024245	0	0
RGS21	431704	broad.mit.edu	37	1	192321195	192321195	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:192321195G>A	uc001gsh.2	+	4	281	c.107G>A	c.(106-108)CGA>CAA	p.R36Q		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	36	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						GATGCTTTTCGAATATTTCTA	0.299000													17	158					0	0	0.008871	0	0
MTPAP	55149	broad.mit.edu	37	10	30658075	30658075	+	Translation_Start_Site	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr10:30658075C>T	uc001ivb.3	-	4	346	c.-1026G>A	c.(-1028--1024)CCGTG>CCATG		LOC729668_uc001ivd.2_Intron|LOC729668_uc001ivf.1_Intron	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor						cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						GCCCAAAGCACGGGGGACAGG	0.587000													19	398					0	0	0.038395	0	0
NLRP10	338322	broad.mit.edu	37	11	7981305	7981305	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:7981305A>T	uc001mfv.1	-	2	1871	c.1854T>A	c.(1852-1854)TGT>TGA	p.C618*		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	618							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGACAGAAGGACATTTTTGCT	0.398000													14	333					0	0	0.016723	0	0
ST5	6764	broad.mit.edu	37	11	8724252	8724252	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:8724252G>A	uc001mgt.2	-	14	2773	c.2587C>T	c.(2587-2589)CGG>TGG	p.R863W	ST5_uc009yfr.2_Missense_Mutation_p.R443W|ST5_uc001mgu.2_Missense_Mutation_p.R443W|ST5_uc001mgv.2_Missense_Mutation_p.R863W|ST5_uc010rbp.1_Missense_Mutation_p.R376W|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	863	DENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TCCATGGGCCGCCGCAGCTCT	0.612000													13	288					0	0	0.016723	0	0
ANO3	63982	broad.mit.edu	37	11	26619970	26619970	+	Missense_Mutation	SNP	C	A	A	rs141900098		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:26619970C>A	uc001mqt.3	+	15	1651	c.1506C>A	c.(1504-1506)GAC>GAA	p.D502E	ANO3_uc010rdr.1_Missense_Mutation_p.D486E|ANO3_uc010rds.1_Missense_Mutation_p.D341E|ANO3_uc010rdt.1_Missense_Mutation_p.D356E	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	502	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						ATACTTGGGACCTTATCGAAT	0.388000													22	415					4.26978e-12	4.63316e-12	0.018920	1	0
FAT3	120114	broad.mit.edu	37	11	92616466	92616466	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:92616466G>A	uc001pdj.3	+	23	12861	c.12844G>A	c.(12844-12846)GTG>ATG	p.V4282M	FAT3_uc001pdi.3_Missense_Mutation_p.V722M	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4282	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGGCGTGGTCGTGTGCAGTGT	0.657000										TCGA Ovarian(4;0.039)			19	333					0	0	0.043863	0	0
CNTN5	53942	broad.mit.edu	37	11	100141958	100141958	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:100141958C>T	uc001pga.2	+	18	2638	c.2299C>T	c.(2299-2301)CGC>TGC	p.R767C	CNTN5_uc001pfz.2_Missense_Mutation_p.R767C|CNTN5_uc001pgb.2_Missense_Mutation_p.R693C|CNTN5_uc010ruk.1_Missense_Mutation_p.R38C	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	767					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCGAATGATCCGCACAAATGA	0.443000													4	137					0	0	0.009096	0	0
C11orf63	79864	broad.mit.edu	37	11	122805736	122805736	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr11:122805736C>T	uc001pym.2	+	5	1884	c.1587C>T	c.(1585-1587)CTC>CTT	p.L529L		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	529										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AGAAACAACTCAAACAGCCTT	0.368000													33	324					0	0	0.013726	0	0
DDX12	440081	broad.mit.edu	37	12	9571764	9571764	+	Missense_Mutation	SNP	T	G	G	rs117821635	by1000genomes	TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:9571764T>G	uc010sgs.1	-	25	2675	c.2480A>C	c.(2479-2481)CAC>CCC	p.H827P	DDX12_uc001qvx.3_Missense_Mutation_p.H49P|DDX12_uc001qvy.1_Missense_Mutation_p.H49P	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						CTTCCCTGGGTGTGCCTGGCC	0.642000													5	25					0	0	0.014758	0	0
Unknown	0	broad.mit.edu	37	12	9713413	9713413	+	RNA	SNP	A	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:9713413A>G	uc001qwb.1	+	5		c.608A>G								Homo sapiens mRNA; cDNA DKFZp686A1124 (from clone DKFZp686A1124).																		TGTATTACAGACTCAGTGCTC	0.358000													2	9					0	0	0.009096	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	T	T	rs121913529		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			12	125					0	0	0.020292	0	0
C12orf40	283461	broad.mit.edu	37	12	40044057	40044057	+	Missense_Mutation	SNP	G	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:40044057G>C	uc001rmc.2	+	7	754	c.587G>C	c.(586-588)TGT>TCT	p.C196S	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	196										ovary(6)	6						ACTGTTAACTGTTCTGATTCC	0.279000													3	149					0	0	0.004672	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771274	43771274	+	Missense_Mutation	SNP	C	T	T	rs112430320		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:43771274C>T	uc010skx.1	-	32	4889	c.4889G>A	c.(4888-4890)CGG>CAG	p.R1630Q		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1630	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AACTATAGGCCGAAGTCGATG	0.413000													7	162					0	0	0.004482	0	0
GLI1	2735	broad.mit.edu	37	12	57861870	57861870	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:57861870G>A	uc001snx.2	+	10	1249	c.1171G>A	c.(1171-1173)GCC>ACC	p.A391T	GLI1_uc009zpq.2_Missense_Mutation_p.A263T	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	391					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGGTCCTGACGCCCATGTGAC	0.572000													14	243					0	0	0.028581	0	0
NCOR2	9612	broad.mit.edu	37	12	124887093	124887093	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr12:124887093C>T	uc010tba.1	-	14	1614	c.1497G>A	c.(1495-1497)CAG>CAA	p.Q499Q	NCOR2_uc010tay.1_Silent_p.Q499Q|NCOR2_uc010taz.1_Silent_p.Q499Q|NCOR2_uc010tbb.1_Silent_p.Q499Q|NCOR2_uc010tbc.1_Silent_p.Q498Q|NCOR2_uc001ugj.1_Silent_p.Q499Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgct	0.328000													4	30					0	0	0.009096	0	0
LOC284232	284232	broad.mit.edu	37	13	19415655	19415655	+	RNA	SNP	C	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr13:19415655C>A	uc010tcj.1	-	1		c.30455G>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						ccaaacaaaacaaaaCAAAAC	0.184000													15	167					6.50621e-10	6.98562e-10	0.013726	1	0
DNAJC3	5611	broad.mit.edu	37	13	96416004	96416004	+	Splice_Site	SNP	T	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr13:96416004T>A	uc001vmq.2	+	8	1062	c.954_splice	c.e8+2	p.K318_splice	DNAJC3_uc001vmr.2_Splice_Site_p.K267_splice	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3						protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			TTTTCTAAGGTAACAGTTGAC	0.398000													56	421					0	0	0.014410	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21792810	21792810	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:21792810C>T	uc001wag.2	+	14	1796	c.1796C>T	c.(1795-1797)CCG>CTG	p.P599L	RPGRIP1_uc001wah.2_Missense_Mutation_p.P241L|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Missense_Mutation_p.P64L|RPGRIP1_uc001wak.2_Missense_Mutation_p.P74L|RPGRIP1_uc010aim.2_Intron|RPGRIP1_uc001wal.2_Missense_Mutation_p.R8C|RPGRIP1_uc001wam.2_5'UTR	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	599					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGCACCCGACCGTTGTCGTTA	0.473000													15	419					0	0	0.028581	0	0
PRKCH	5583	broad.mit.edu	37	14	61789073	61789073	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:61789073C>T	uc001xfn.2	+	1	559	c.254C>T	c.(253-255)GCC>GTC	p.A85V	PRKCH_uc010tsa.1_Intron|uc001xfm.2_Intron	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	85	C2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		CTCGAGTTGGCCGTCTTCCAC	0.642000													5	267					0	0	0.021553	0	0
GPR68	8111	broad.mit.edu	37	14	91700906	91700906	+	Silent	SNP	G	A	A	rs145413696		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:91700906G>A	uc001xzg.2	-	2	830	c.489C>T	c.(487-489)ATC>ATT	p.I163I	GPR68_uc001xzh.2_Silent_p.I173I	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	163	Extracellular (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		TCTCGTCCTCGATGACCTCCT	0.617000													9	138					0	0	0.008291	0	0
ATG2B	55102	broad.mit.edu	37	14	96790267	96790267	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:96790267C>T	uc001yfi.2	-	16	2871	c.2506G>A	c.(2506-2508)GAT>AAT	p.D836N		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	836										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GATGTTGTATCTCCATCTACT	0.348000													11	274					0	0	0.013537	0	0
CYP46A1	10858	broad.mit.edu	37	14	100182237	100182237	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:100182237C>T	uc001ygo.2	+	8	784	c.784C>T	c.(784-786)CGG>TGG	p.R262W	CYP46A1_uc001ygp.2_Missense_Mutation_p.R109W	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	262					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCAGCGCCGCCGGGAAGCCCT	0.657000													9	248					0	0	0.004482	0	0
RYR3	6263	broad.mit.edu	37	15	33962623	33962623	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr15:33962623T>G	uc001zhi.2	+	38	5796	c.5726T>G	c.(5725-5727)GTT>GGT	p.V1909G	RYR3_uc010bar.2_Missense_Mutation_p.V1909G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1909	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGCTAGGGGTTCCTTTggaa	0.398000													24	71					0	0	0.036044	0	0
CPEB1	64506	broad.mit.edu	37	15	83226611	83226611	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr15:83226611G>A	uc002bit.2	-	4	822	c.685C>T	c.(685-687)CGC>TGC	p.R229C	CPEB1_uc002biq.2_Missense_Mutation_p.R94C|CPEB1_uc002bir.2_Missense_Mutation_p.R94C|CPEB1_uc002bis.2_Missense_Mutation_p.R94C|CPEB1_uc010uod.1_Intron|CPEB1_uc010uoe.1_Missense_Mutation_p.R172C|CPEB1_uc002biu.2_Missense_Mutation_p.R196C|CPEB1_uc010uof.1_Missense_Mutation_p.R94C|CPEB1_uc002biv.2_Missense_Mutation_p.R169C|CPEB1_uc002bip.2_5'Flank	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	169					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GTGTCCAGGCGTGATCCTCTA	0.552000													12	327					0	0	0.010729	0	0
SRRM2	23524	broad.mit.edu	37	16	2817974	2817974	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr16:2817974C>T	uc002crk.2	+	11	7994	c.7445C>T	c.(7444-7446)ACG>ATG	p.T2482M	SRRM2_uc002crj.1_Missense_Mutation_p.T2386M|SRRM2_uc002crl.1_Missense_Mutation_p.T2482M|SRRM2_uc010bsu.1_Missense_Mutation_p.T2386M	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2482	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCAGTGGCAACGACCACGTCC	0.602000													12	333					0	0	0.013537	0	0
MEFV	4210	broad.mit.edu	37	16	3299561	3299561	+	Missense_Mutation	SNP	C	T	T	rs144998416		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr16:3299561C>T	uc002cun.1	-	3	1170	c.1130G>A	c.(1129-1131)CGC>CAC	p.R377H		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	377	B box-type.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CTTCAGGTGGCGCTTACACTG	0.647000													21	244					0	0	0.012319	0	0
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	T	T	rs28934576	by1000genomes	TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	145					0	0	0.028581	0	0
ALOX15B	247	broad.mit.edu	37	17	7942847	7942847	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:7942847G>A	uc002gju.2	+	2	407	c.291G>A	c.(289-291)CCG>CCA	p.P97P	ALOX15B_uc002gjv.2_Silent_p.P97P|ALOX15B_uc002gjw.2_Silent_p.P97P|ALOX15B_uc010vun.1_Silent_p.P97P|ALOX15B_uc010cnp.2_5'UTR	NM_001141	NP_001132	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, second type	97	PLAT.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			ovary(1)	1						TGACACCGCCGCGGGGCGGCC	0.746000													4	29					0	0	0.014758	0	0
TRIM16	10626	broad.mit.edu	37	17	15517181	15517181	+	Silent	SNP	A	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:15517181A>C	uc002gor.1	-	9	2104	c.1767T>G	c.(1765-1767)CGT>CGG	p.R589R	CDRT1_uc002gov.3_Silent_p.R279R			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;	Error:Variant_position_missing_in_O95361_after_alignment					histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		TGGGCAGGTAACGGATGAAGT	0.512000													17	399					0	0	0.018920	0	0
FLII	2314	broad.mit.edu	37	17	18154700	18154700	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:18154700G>A	uc002gsr.1	-	13	1526	c.1475C>T	c.(1474-1476)ACG>ATG	p.T492M	FLII_uc002gsq.1_Missense_Mutation_p.T363M|FLII_uc010cpy.1_Missense_Mutation_p.T481M|FLII_uc010vxn.1_Missense_Mutation_p.T461M|FLII_uc010vxo.1_Missense_Mutation_p.T437M|FLII_uc002gss.1_Missense_Mutation_p.T491M	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	492					multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					CACGTCCTCCGTGAAGAACTC	0.652000													51	513					0	0	0.014410	0	0
AP2B1	163	broad.mit.edu	37	17	33977630	33977630	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:33977630G>A	uc002hjr.2	+	13	1807	c.1618G>A	c.(1618-1620)GTA>ATA	p.V540I	AP2B1_uc002hjq.2_Missense_Mutation_p.V540I|AP2B1_uc010wci.1_Missense_Mutation_p.V502I|AP2B1_uc002hjs.2_Missense_Mutation_p.V483I|AP2B1_uc002hjt.2_Missense_Mutation_p.V540I|AP2B1_uc010ctv.2_Missense_Mutation_p.V540I|AP2B1_uc010wcj.1_Missense_Mutation_p.V277I	NM_001282	NP_001273	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1	540					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGCTAAAGAAGTAGTCTTGTC	0.473000													47	572					0	0	0.045515	0	0
KRT15	3866	broad.mit.edu	37	17	39673185	39673185	+	Missense_Mutation	SNP	C	T	T	rs138271368		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:39673185C>T	uc002hwy.2	-	3	804	c.613G>A	c.(613-615)GTT>ATT	p.V205I	KRT15_uc002hwz.2_Missense_Mutation_p.V107I|KRT15_uc002hxa.2_Missense_Mutation_p.V40I|KRT15_uc002hxb.1_Missense_Mutation_p.V40I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	205	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TCAGCCTCAACGCCCTGGCGC	0.612000													19	377					0	0	0.008871	0	0
KCNJ2	3759	broad.mit.edu	37	17	68172063	68172063	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:68172063G>A	uc010dfg.2	+	2	1284	c.883G>A	c.(883-885)GTG>ATG	p.V295M	KCNJ2_uc002jir.2_Missense_Mutation_p.V295M	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	295	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					CTTTGAAATCGTGGTCATACT	0.458000													13	303					0	0	0.016723	0	0
RNF213	57674	broad.mit.edu	37	17	78321227	78321227	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:78321227G>A	uc002jyh.1	+	4	3534	c.3311G>A	c.(3310-3312)GGT>GAT	p.G1104D		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AAGGTGCCGGGTGGAGAGCAG	0.547000													20	243					0	0	0.008871	0	0
PTPRM	5797	broad.mit.edu	37	18	7774244	7774244	+	Silent	SNP	G	A	A	rs145799313		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr18:7774244G>A	uc002knn.3	+	2	674	c.171G>A	c.(169-171)CCG>CCA	p.P57P	PTPRM_uc010dkv.2_Silent_p.P57P	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	57	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TGACTAAACCGACTTCTGATC	0.403000													12	444					0	0	0.024245	0	0
LOC644669	644669	broad.mit.edu	37	18	15316743	15316743	+	RNA	SNP	A	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr18:15316743A>G	uc002ktd.1	-	5		c.291T>C				NR_027417				Homo sapiens cDNA FLJ40312 fis, clone TESTI2029880.												0						AGCCTCATCAAGTGTTCCTTC	0.428000													6	22					0	0	0.020292	0	0
ADNP2	22850	broad.mit.edu	37	18	77896690	77896690	+	Nonstop_Mutation	SNP	T	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr18:77896690T>A	uc002lnw.2	+	4	3849	c.3394T>A	c.(3394-3396)TAA>AAA	p.*1132K		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	1132					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		ATATGAACCATAAAACTTGCA	0.303000													11	44					0	0	0.024245	0	0
FBN3	84467	broad.mit.edu	37	19	8206691	8206691	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr19:8206691G>A	uc002mjf.2	-	7	796	c.775C>T	c.(775-777)CAG>TAG	p.Q259*		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	259	EGF-like 2; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTGCCTCcctggcacaggcct	0.517000													18	262					0	0	0.010504	0	0
EMR2	30817	broad.mit.edu	37	19	14854232	14854232	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr19:14854232C>T	uc002mzp.1	-	20	2919	c.2463G>A	c.(2461-2463)ACG>ACA	p.T821T	EMR2_uc010dzs.1_Silent_p.T280T|EMR2_uc010xnw.1_Silent_p.T763T|EMR2_uc002mzo.1_Silent_p.T810T|EMR2_uc002mzq.1_Silent_p.T761T|EMR2_uc002mzr.1_Silent_p.T772T|EMR2_uc002mzs.1_Silent_p.T679T|EMR2_uc002mzt.1_Silent_p.T717T|EMR2_uc002mzu.1_Silent_p.T728T	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	821	Cytoplasmic (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						GTGATCTTACCGTGCTGGGTT	0.507000													10	754					0	0	0.013537	0	0
LILRA1	11024	broad.mit.edu	37	19	55106342	55106342	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr19:55106342C>T	uc002qgh.1	+	4	465	c.283C>T	c.(283-285)CGG>TGG	p.R95W	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.R95W	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	95	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		ACACACAGGGCGGTATCGCTG	0.572000													16	450					0	0	0.043863	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460205	107460205	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:107460205G>A	uc002tdq.2	-	2	348	c.229C>T	c.(229-231)CGC>TGC	p.R77C	ST6GAL2_uc002tdr.2_Missense_Mutation_p.R77C|ST6GAL2_uc002tds.3_Missense_Mutation_p.R77C	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	77	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						AGCGCCTGGCGTGCGTCCAGG	0.677000													25	240					0	0	0.016522	0	0
MIR10B	406903	broad.mit.edu	37	2	177015088	177015088	+	RNA	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:177015088G>A	hsa-mir-10b|MI0000267	+			c.58G>A			uc010zey.1_RNA|HOXD4_uc002uks.2_5'Flank																	0						TGTGGTATCCGTATAGTCACA	0.473000													29	328					0	0	0.037714	0	0
TTC30A	92104	broad.mit.edu	37	2	178482747	178482747	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:178482747C>T	uc002ulo.2	-	1	948	c.683G>A	c.(682-684)GGC>GAC	p.G228D		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	228					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			GGTGGTCATGCCCACACCTAG	0.527000													5	302					0	0	0.021553	0	0
DFNB59	494513	broad.mit.edu	37	2	179319081	179319081	+	Silent	SNP	G	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:179319081G>C	uc002umi.3	+	3	590	c.234G>C	c.(232-234)CTG>CTC	p.L78L	DFNB59_uc002umj.3_Silent_p.L78L	NM_001042702	NP_001036167	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	78					sensory perception of sound						0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			ATCAATTACTGAATTATGAAG	0.299000													18	328					0	0	0.010504	0	0
TTN	7273	broad.mit.edu	37	2	179569272	179569272	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:179569272C>T	uc010zfg.1	-	102	26419	c.26195G>A	c.(26194-26196)GGT>GAT	p.G8732D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G5393D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9659							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGTGTGGACCACAAACCAA	0.383000													8	185					0	0	0.038147	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492919	21492919	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:21492919G>A	uc002wsi.2	-	2	821	c.464C>T	c.(463-465)GCG>GTG	p.A155V		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	155	Homeobox.				brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						GCGCTCGGGCGCCGACAGGTA	0.672000													5	131					0	0	0.014758	0	0
REM1	28954	broad.mit.edu	37	20	30064350	30064350	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:30064350C>T	uc002wwa.2	+	2	386	c.102C>T	c.(100-102)AGC>AGT	p.S34S		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	34					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GCCGCCTGAGCACAGTGCCTT	0.642000													40	375					0	0	0.021022	0	0
NCOA6	23054	broad.mit.edu	37	20	33324555	33324555	+	Silent	SNP	C	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:33324555C>A	uc002xav.2	-	13	8472	c.5901G>T	c.(5899-5901)TCG>TCT	p.S1967S	NCOA6_uc002xaw.2_Silent_p.S1967S	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1967	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTAAATTCTGCGACGGGGCTA	0.418000													19	181					3.99206e-14	4.37839e-14	0.043863	1	0
SGK2	10110	broad.mit.edu	37	20	42198157	42198157	+	Splice_Site	SNP	G	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:42198157G>T	uc002xkv.2	+	5	759	c.540_splice	c.e5+1	p.E180_splice	SGK2_uc002xkt.2_Splice_Site|SGK2_uc002xkr.2_Splice_Site_p.E120_splice|SGK2_uc010ggm.2_Splice_Site_p.E120_splice|SGK2_uc002xks.2_Splice_Site_p.E119_splice|SGK2_uc002xku.2_Splice_Site_p.E120_splice	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform						intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CGGGGGAGAGGTGGGTGGGCC	0.602000													19	287					3.83957e-06	3.99629e-06	0.016522	1	0
MMP9	4318	broad.mit.edu	37	20	44641961	44641961	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:44641961G>A	uc002xqz.2	+	9	1417	c.1398G>A	c.(1396-1398)ACG>ACA	p.T466T		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	466					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CTCCCCCGACGGTCTGCCCCA	0.463000											OREG0025990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	463					0	0	0.014410	0	0
ZNF512B	57473	broad.mit.edu	37	20	62597787	62597787	+	Silent	SNP	G	A	A	rs142867495	byFrequency	TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr20:62597787G>A	uc002yhl.1	-	5	795	c.741C>T	c.(739-741)CCC>CCT	p.P247P		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCTTGGTGACGGGCATGGGCC	0.597000													69	885					0	0	0.014410	0	0
ULK4	54986	broad.mit.edu	37	3	41504591	41504591	+	Missense_Mutation	SNP	C	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:41504591C>A	uc003ckv.3	-	33	3581	c.3380G>T	c.(3379-3381)CGG>CTG	p.R1127L		NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	1127							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CAAAGCCAGCCGTACAATACC	0.443000													33	347					6.00712e-18	6.66007e-18	0.012213	1	0
C3orf63	23272	broad.mit.edu	37	3	56662562	56662562	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:56662562C>T	uc003did.3	-	18	3746	c.3645G>A	c.(3643-3645)TTG>TTA	p.L1215L	C3orf63_uc003dib.3_Silent_p.L334L|C3orf63_uc003dic.3_Silent_p.L839L|C3orf63_uc003die.3_Silent_p.L1276L	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	1276										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		GAATAATAATCAATAGTTTAT	0.274000													18	197					0	0	0.038395	0	0
KALRN	8997	broad.mit.edu	37	3	124103747	124103747	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:124103747C>T	uc003ehg.2	+	11	1947	c.1820C>T	c.(1819-1821)ACG>ATG	p.T607M	KALRN_uc010hrv.1_Missense_Mutation_p.T607M|KALRN_uc003ehf.1_Missense_Mutation_p.T607M|KALRN_uc011bjy.1_Missense_Mutation_p.T607M|KALRN_uc003ehh.1_Translation_Start_Site	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	607	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						TTGGCTCAGACGGGGGAATGT	0.577000													12	384					0	0	0.010729	0	0
TNIK	23043	broad.mit.edu	37	3	170912426	170912426	+	Splice_Site	SNP	T	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:170912426T>G	uc003fhh.2	-	5	652	c.307_splice	c.e5-1	p.L103_splice	TNIK_uc003fhi.2_Splice_Site_p.L103_splice|TNIK_uc003fhj.2_Splice_Site_p.L103_splice|TNIK_uc003fhk.2_Splice_Site_p.L103_splice|TNIK_uc003fhl.2_Splice_Site_p.L103_splice|TNIK_uc003fhm.2_Splice_Site_p.L103_splice|TNIK_uc003fhn.2_Splice_Site_p.L103_splice|TNIK_uc003fho.2_Splice_Site_p.L103_splice	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1						actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CATCACCAACTGGCAAAGGAA	0.443000													23	279					0	0	0.023175	0	0
CHRD	8646	broad.mit.edu	37	3	184104344	184104344	+	Missense_Mutation	SNP	T	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:184104344T>G	uc003fov.2	+	16	2243	c.1997T>G	c.(1996-1998)GTG>GGG	p.V666G	CHRD_uc003fow.2_Missense_Mutation_p.V296G|CHRD_uc003fox.2_Missense_Mutation_p.V666G|CHRD_uc003foy.2_Missense_Mutation_p.V296G|CHRD_uc010hyc.2_Missense_Mutation_p.V256G|CHRD_uc011brr.1_Intron	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	666					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCGAGGGGGTGCGGGCGCTG	0.726000													7	31					0	0	0.010504	0	0
NR2F1	7025	broad.mit.edu	37	5	92923762	92923762	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr5:92923762G>A	uc003kkj.2	+	2	2290	c.603G>A	c.(601-603)TCG>TCA	p.S201S		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	201					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		ACCCCACGTCGCGCTACGGCA	0.667000													14	393					0	0	0.033300	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559172	140559172	+	Silent	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr5:140559172G>A	uc011dai.1	+	1	1743	c.1557G>A	c.(1555-1557)TCG>TCA	p.S519S	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	519	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTCAGGTCGCTGGACTACG	0.687000													22	811					0	0	0.012319	0	0
FBXW11	23291	broad.mit.edu	37	5	171303381	171303381	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr5:171303381G>A	uc003mbm.1	-	8	1437	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C	FBXW11_uc011dey.1_Missense_Mutation_p.R324C|FBXW11_uc003mbl.1_Missense_Mutation_p.R343C|FBXW11_uc003mbn.1_Missense_Mutation_p.R322C	NM_012300	NP_036432	Q9UKB1	FBW1B_HUMAN	F-box and WD repeat domain containing 11 isoform	356					cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of circadian rhythm|positive regulation of proteolysis|positive regulation of transcription, DNA-dependent|protein dephosphorylation|protein destabilization|protein polyubiquitination|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	centrosome|cytosol|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)|breast(1)	2	Renal(175;0.000159)|Lung NSC(126;0.00384)|all_lung(126;0.00659)	Medulloblastoma(196;0.00853)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGGACACGGCGTAAAGTGATG	0.522000													4	131					0	0	0.009096	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775481	27775481	+	Missense_Mutation	SNP	G	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr6:27775481G>C	uc003njl.2	-	1	229	c.204C>G	c.(202-204)AAC>AAG	p.N68K	HIST1H3H_uc003njm.2_5'Flank	NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	68					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CGAAGATGTCGTTGACGAAGG	0.597000													69	749					0	0	0.014410	0	0
TRIM40	135644	broad.mit.edu	37	6	30104878	30104878	+	Missense_Mutation	SNP	A	G	G			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr6:30104878A>G	uc003npk.2	+	2	451	c.65A>G	c.(64-66)AAG>AGG	p.K22R	TRIM40_uc003npl.1_RNA|TRIM40_uc003npm.2_Missense_Mutation_p.K22R	NM_138700	NP_619645	Q6P9F5	TRI40_HUMAN	tripartite motif-containing 40	22	RING-type.					intracellular	zinc ion binding			ovary(1)	1						GAGAGCCTGAAGGAGGCCGTG	0.602000													8	290					0	0	0.038147	0	0
QKI	9444	broad.mit.edu	37	6	163987788	163987788	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr6:163987788C>T	uc003qui.2	+	7	1521	c.970C>T	c.(970-972)CGT>TGT	p.R324C	QKI_uc003que.2_3'UTR|QKI_uc003quf.2_3'UTR|QKI_uc003qug.2_3'UTR|QKI_uc003quh.2_3'UTR|QKI_uc003quj.2_Missense_Mutation_p.R316C	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	324	Nuclear localization signal (By similarity).				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GCACGATATGCGTGTCCATCC	0.413000													10	156					0	0	0.008291	0	0
CPA2	1358	broad.mit.edu	37	7	129909574	129909574	+	Silent	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr7:129909574C>T	uc003vpq.2	+	3	238	c.219C>T	c.(217-219)AAC>AAT	p.N73N	CPA2_uc011kpc.1_Silent_p.N73N	NM_001869	NP_001860	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic) precursor	73					proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					CCTTCGTCAACGTCCAGGCAG	0.502000													20	351					0	0	0.043863	0	0
MCM4	4173	broad.mit.edu	37	8	48887486	48887486	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr8:48887486C>T	uc003xqk.1	+	15	2424	c.2329C>T	c.(2329-2331)CGG>TGG	p.R777W	MCM4_uc003xql.1_Missense_Mutation_p.R777W|MCM4_uc011ldi.1_Missense_Mutation_p.R764W	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	777					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				AACTGATCCCCGGACTGGCAT	0.408000													14	404					0	0	0.016723	0	0
SULF1	23213	broad.mit.edu	37	8	70512900	70512900	+	Missense_Mutation	SNP	C	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr8:70512900C>A	uc010lza.1	+	9	1514	c.797C>A	c.(796-798)CCA>CAA	p.P266Q	SULF1_uc003xyd.2_Missense_Mutation_p.P266Q|SULF1_uc003xye.2_Missense_Mutation_p.P266Q|SULF1_uc003xyf.2_Missense_Mutation_p.P266Q|SULF1_uc003xyg.2_Missense_Mutation_p.P266Q|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	266					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TACACAGGACCAATGCTGCCC	0.393000													18	533					5.35267e-07	5.62858e-07	0.043863	1	0
KIAA1797	54914	broad.mit.edu	37	9	20789554	20789554	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr9:20789554C>T	uc003zog.1	+	13	1765	c.1402C>T	c.(1402-1404)CTT>TTT	p.L468F		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	468						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		AGGACAAAATCTTCACCAAAT	0.438000													31	364					0	0	0.045705	0	0
COL5A1	1289	broad.mit.edu	37	9	137593108	137593108	+	Missense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr9:137593108G>A	uc004cfe.2	+	4	965	c.583G>A	c.(583-585)GAC>AAC	p.D195N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	195	TSP N-terminal.|Laminin G-like.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CGACCGCAGCGACCACCCCAT	0.527000													9	135					0	0	0.006214	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070111	141070111	+	Silent	SNP	T	C	C	rs139643347	by1000genomes	TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr9:141070111T>C	uc004com.2	+	3	270	c.9T>C	c.(7-9)TCT>TCC	p.S3S	TUBBP5_uc010ncq.2_Silent_p.S117S					RecName: Full=Putative tubulin beta-4q chain;												0						CCATGGACTCTGTGCGCTCGG	0.697000													7	320					0	0	0.008291	0	0
KDM6A	7403	broad.mit.edu	37	X	44936003	44936003	+	Nonsense_Mutation	SNP	A	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:44936003A>T	uc004dge.3	+	18	3139	c.2764A>T	c.(2764-2766)AGA>TGA	p.R922*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R888*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R974*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R877*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R929*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R626*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R561*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	922					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TCCACCTCCAAGACCACCATC	0.373000			D|N|F|S		renal|oesophageal SCC|MM								21	445					0	0	0.012319	0	0
UBA1	7317	broad.mit.edu	37	X	47058941	47058941	+	Silent	SNP	T	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:47058941T>C	uc004dhj.3	+	5	559	c.408T>C	c.(406-408)GCT>GCC	p.A136A	UBA1_uc004dhk.3_Silent_p.A136A	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	136	1-1.|2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						CCCGCCTCGCTGAGCTCAACA	0.547000													18	525					0	0	0.033300	0	0
NONO	4841	broad.mit.edu	37	X	70519912	70519912	+	Missense_Mutation	SNP	C	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:70519912C>T	uc004dzo.2	+	13	2112	c.1402C>T	c.(1402-1404)CGT>TGT	p.R468C	BCYRN1_uc011mpt.1_Intron|NONO_uc004dzn.2_Missense_Mutation_p.R468C|NONO_uc004dzp.2_Missense_Mutation_p.R468C|NONO_uc011mpv.1_Missense_Mutation_p.R379C|NONO_uc004dzq.2_Missense_Mutation_p.R337C|ITGB1BP2_uc004dzr.1_5'Flank|ITGB1BP2_uc004dzs.1_5'Flank	NM_001145408	NP_001138880	Q15233	NONO_HUMAN	non-POU domain containing, octamer-binding	468					DNA recombination|DNA repair|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|identical protein binding|nucleotide binding|RNA binding		NONO/TFE3(2)	ovary(2)|kidney(2)	4	Renal(35;0.156)					CCCAAACAAACGTCGCCGATA	0.468000			T	TFE3	papillary renal cancer								30	480					0	0	0.013726	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249463	119249463	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:119249463G>A	uc004esk.1	-	1	385	c.310C>T	c.(310-312)CGA>TGA	p.R104*	uc004esi.1_Intron	NM_139282	NP_644811	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	104	Homeobox.				gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGCCGAGTTCGTGGCTGCATG	0.652000													40	516					0	0	0.033182	0	0
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:7838212_7838214delTCA	uc001aol.2	+	4	381_383	c.266_268delTCA	c.(265-270)TTCATC>TTC	p.I94del		NM_004781	NP_004772	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	94	Helical; Anchor for type IV membrane protein; (Potential).				cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													9	1057	---	---	---	---					
WDR78	79819	broad.mit.edu	37	1	67390426	67390426	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr1:67390426delT	uc001dcx.2	-	1	145	c.89delA	c.(88-90)AAGfs	p.K30fs	WDR78_uc001dcy.2_Frame_Shift_Del_p.K30fs|WDR78_uc001dcz.2_Frame_Shift_Del_p.K30fs|MIER1_uc001dda.3_5'Flank|MIER1_uc010opf.1_5'Flank|MIER1_uc009way.2_5'Flank|MIER1_uc001ddc.2_5'Flank|MIER1_uc001ddh.2_5'Flank|MIER1_uc001ddf.2_5'Flank|MIER1_uc001ddg.2_5'Flank|MIER1_uc010opg.1_5'Flank|MIER1_uc001dde.2_5'Flank	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	30										ovary(2)	2						GCACCACCCCTTTTTTTGGCC	0.622													10	819	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24822125	24822127	+	In_Frame_Del	DEL	GAA	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr10:24822125_24822127delGAA	uc001iru.3	+	16	3776_3778	c.3373_3375delGAA	c.(3373-3375)GAAdel	p.E1129del	KIAA1217_uc001irs.2_In_Frame_Del_p.E1049del|KIAA1217_uc001irt.3_In_Frame_Del_p.E1094del|KIAA1217_uc010qcy.1_In_Frame_Del_p.E1093del|KIAA1217_uc010qcz.1_In_Frame_Del_p.E1094del|KIAA1217_uc001irw.2_In_Frame_Del_p.E812del|KIAA1217_uc001irz.2_In_Frame_Del_p.E812del|KIAA1217_uc001irx.2_In_Frame_Del_p.E812del|KIAA1217_uc001iry.2_In_Frame_Del_p.E812del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1129					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GGATGAGGAGGAAGAAGAAGAAG	0.552													8	293	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr10:98336475delT	uc001kmm.3	-	2	431	c.214delA	c.(214-216)AGTfs	p.S72fs	TM9SF3_uc010qot.1_Frame_Shift_Del_p.S72fs	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	72						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363													7	795	---	---	---	---					
C14orf4	64207	broad.mit.edu	37	14	77493647	77493648	+	In_Frame_Ins	INS	-	GCG	GCG	rs61991619		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr14:77493647_77493648insGCG	uc001xsy.2	-	1	1387_1388	c.488_489insCGC	c.(487-489)GCT>GCCGCT	p.163_163A>AA		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	163	Poly-Ala.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		GTTCCACCgcagcggcggcggc	0.579													9	58	---	---	---	---					
SPATA5L1	79029	broad.mit.edu	37	15	45710840	45710841	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr15:45710840_45710841insT	uc001zve.2	+	7	2163_2164	c.2054_2055insT	c.(2053-2055)TGTfs	p.C685fs	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	685						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GCAGAAACCTGTTTTTTTTCTG	0.356													7	451	---	---	---	---					
KRT12	3859	broad.mit.edu	37	17	39022893	39022894	+	Frame_Shift_Ins	INS	-	AGTG	AGTG			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr17:39022893_39022894insAGTG	uc002hvk.2	-	1	569_570	c.545_546insCACT	c.(544-546)CTGfs	p.L182fs		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	182	Rod.|Linker 1.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGTCTTCAATCAGTGGATAATA	0.371													25	855	---	---	---	---					
C18orf34	374864	broad.mit.edu	37	18	30913143	30913143	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr18:30913143delT	uc002kxn.2	-	9	1016	c.874delA	c.(874-876)ATGfs	p.M292fs	C18orf34_uc010xbr.1_Frame_Shift_Del_p.M292fs|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Frame_Shift_Del_p.M292fs|C18orf34_uc002kxp.2_Frame_Shift_Del_p.M292fs	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	292	Potential.									ovary(1)	1						TTTACCTCCATTTTTTTTTTA	0.318													8	286	---	---	---	---					
PLAUR	5329	broad.mit.edu	37	19	44174235	44174237	+	In_Frame_Del	DEL	AGC	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr19:44174235_44174237delAGC	uc002oxf.1	-	1	266_268	c.36_38delGCT	c.(34-39)CTGCTC>CTC	p.12_13LL>L	PLAUR_uc002oxd.1_In_Frame_Del_p.12_13LL>L|PLAUR_uc002oxe.1_5'Flank|PLAUR_uc002oxg.1_In_Frame_Del_p.12_13LL>L	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	12_13					attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	GCAGGTGTGGagcagcagcagca	0.562													7	546	---	---	---	---					
OTOF	9381	broad.mit.edu	37	2	26693554	26693556	+	In_Frame_Del	DEL	CTT	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:26693554_26693556delCTT	uc002rhk.2	-	32	4055_4057	c.3928_3930delAAG	c.(3928-3930)AAGdel	p.K1310del	OTOF_uc010yla.1_In_Frame_Del_p.K40del|OTOF_uc002rhh.2_In_Frame_Del_p.K543del|OTOF_uc002rhi.2_In_Frame_Del_p.K620del|OTOF_uc002rhj.2_In_Frame_Del_p.K543del	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1310	Cytoplasmic (Potential).|Poly-Lys.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCAGTGCCcttcttcttcttc	0.507													8	457	---	---	---	---					
GAD1	2571	broad.mit.edu	37	2	171702549	171702549	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr2:171702549delA	uc002ugi.2	+	10	1400	c.978delA	c.(976-978)GCAfs	p.A326fs		NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	326					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATTTTGAGGCAAAAATTCTTG	0.353													7	476	---	---	---	---					
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr21:10944697delA	uc002yip.1	-	11	905	c.537delT	c.(535-537)TTTfs	p.F179fs	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Frame_Shift_Del_p.F161fs|TPTE_uc002yir.1_Frame_Shift_Del_p.F141fs|TPTE_uc010gkv.1_Frame_Shift_Del_p.F41fs	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299													13	1239	---	---	---	---					
P2RY13	53829	broad.mit.edu	37	3	151046142	151046142	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr3:151046142delT	uc003eyv.2	-	2	723	c.702delA	c.(700-702)AAAfs	p.K234fs	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	234	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			AATCATATACTTTTTTTGCAA	0.338													7	375	---	---	---	---					
SCLT1	132320	broad.mit.edu	37	4	129864162	129864163	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr4:129864162_129864163insT	uc003igp.2	-	17	2126_2127	c.1620_1621insA	c.(1618-1623)AAAGCCfs	p.K540fs	SCLT1_uc003ign.2_Frame_Shift_Ins_p.K204fs|SCLT1_uc003igo.2_Frame_Shift_Ins_p.K150fs|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	540_541	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TTTACTTTGGCTTTTTTTTGAG	0.356													7	650	---	---	---	---					
BAT2	7916	broad.mit.edu	37	6	31597456	31597457	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr6:31597456_31597457insC	uc003nvb.3	+	14	2337_2338	c.2088_2089insC	c.(2086-2091)CCACCCfs	p.P696fs	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Frame_Shift_Ins_p.P696fs	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	696_697	Poly-Pro.|4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CACAGGCTCCACCCCCGCCCCC	0.594													8	153	---	---	---	---					
RELN	5649	broad.mit.edu	37	7	103629803	103629804	+	Translation_Start_Site	INS	-	GCCGCC	GCCGCC			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr7:103629803_103629804insGCCGCC	uc003vca.2	-	1					RELN_uc010liz.2_Translation_Start_Site	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCGCTCCATgccgccgccgc	0.569													10	48	---	---	---	---					
FGFR1	2260	broad.mit.edu	37	8	38285914	38285916	+	In_Frame_Del	DEL	TCA	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr8:38285914_38285916delTCA	uc003xlp.2	-	4	1338_1340	c.396_398delTGA	c.(394-399)GATGAC>GAC	p.132_133DD>D	FGFR1_uc011lbo.1_In_Frame_Del_p.132_133DD>D|FGFR1_uc011lbp.1_In_Frame_Del_p.43_44DD>D|FGFR1_uc011lbq.1_In_Frame_Del_p.43_44DD>D|FGFR1_uc010lwk.2_In_Frame_Del_p.124_125DD>D|FGFR1_uc011lbr.1_RNA|FGFR1_uc011lbs.1_5'UTR|FGFR1_uc011lbt.1_In_Frame_Del_p.43_44DD>D|FGFR1_uc011lbu.1_In_Frame_Del_p.165_166DD>D|FGFR1_uc011lbv.1_In_Frame_Del_p.132_133DD>D|FGFR1_uc011lbw.1_In_Frame_Del_p.43_44DD>D|FGFR1_uc011lbx.1_In_Frame_Del_p.43_44DD>D|FGFR1_uc003xlv.2_In_Frame_Del_p.43_44DD>D|FGFR1_uc003xlu.2_In_Frame_Del_p.43_44DD>D|FGFR1_uc003xlw.1_RNA	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	132_133	Extracellular (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity	p.D133N(3)|p.D44N(1)		lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	TGAAGAGGAGtcatcatcatcat	0.463		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						7	133	---	---	---	---					
C8orf59	401466	broad.mit.edu	37	8	86129664	86129664	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr8:86129664delT	uc010mac.1	-	3	305	c.65delA	c.(64-66)AACfs	p.N22fs	C8orf59_uc003ydd.2_Frame_Shift_Del_p.N22fs|C8orf59_uc010mad.1_Frame_Shift_Del_p.N22fs|C8orf59_uc003yde.2_Frame_Shift_Del_p.N22fs|C8orf59_uc011lfu.1_RNA	NM_001099670	NP_001093140	Q8N0T1	CH059_HUMAN	hypothetical protein LOC401466	22											0						AGCCTTAAAGTTTTTTTGGCT	0.343													9	891	---	---	---	---					
EIF2C2	27161	broad.mit.edu	37	8	141554345	141554345	+	Frame_Shift_Del	DEL	G	-	-	rs148575703	byFrequency	TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr8:141554345delG	uc003yvn.2	-	14	1846	c.1806delC	c.(1804-1806)CCCfs	p.P602fs	EIF2C2_uc010men.2_Frame_Shift_Del_p.P525fs|EIF2C2_uc010meo.2_Frame_Shift_Del_p.P602fs	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	602	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CATCCCCGGCGGGGGGGTGAG	0.647													8	998	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	68414118	68414118	+	RNA	DEL	G	-	-	rs71221469		TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr9:68414118delG	uc004aex.2	+	1		c.673delG								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		GCTCACGAAAGCCCCCTGTGG	0.667													8	120	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135946954	135946955	+	Frame_Shift_Ins	INS	-	C	C			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chr9:135946954_135946955insC	uc010naa.1	+	11	2090_2091	c.2074_2075insC	c.(2074-2076)GCCfs	p.A692fs		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	689	12.|17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).			A -> P (in Ref. 5; AAB35488).	cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TGACTCCGGCGCCCCCCCCGTG	0.589													4	8	---	---	---	---					
SSX8	280659	broad.mit.edu	37	X	52662823	52662824	+	RNA	DEL	AC	-	-			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:52662823_52662824delAC	uc011mob.1	+	8		c.1272_1273delAC				NR_027250				Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0						acaccacacaacacacacacac	0.391													4	3	---	---	---	---					
FAM155B	27112	broad.mit.edu	37	X	68725671	68725672	+	Frame_Shift_Ins	INS	-	A	A			TCGA-FZ-5926-01A-11D-1609-08	TCGA-FZ-5926-11A-01D-1609-08									Somatic	Phase_I	Capture				Illumina GAIIx	678f111c-8182-487b-bc63-cc2f7521fb3c	9ae69267-3357-4cdc-8308-413098f2a731	g.chrX:68725671_68725672insA	uc004dxk.2	+	1	594_595	c.546_547insA	c.(544-549)GCCAAAfs	p.A182fs		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	182_183						integral to membrane				ovary(1)|breast(1)	2						TCCCCTCCGCCAAAAAAAACTT	0.589													8	344	---	---	---	---					
