Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf187	374946	broad.mit.edu	37	1	11771907	11771907	+	Splice_Site	SNP	G	A	A	rs147444302		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:11771907G>A	uc001asr.1	+	4	783	c.643_splice	c.e4-1	p.Q215_splice		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor						axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		ACGGTCTCCAGCAGGCACAGC	0.552000													6	20					0	0	0.00116845	0	0
CROCCL1	84809	broad.mit.edu	37	1	16946396	16946396	+	RNA	SNP	C	T	T	rs367013	byFrequency	TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:16946396C>T	uc010ocf.1	-	3		c.502G>A			CROCCL1_uc009vov.1_RNA|CROCCL1_uc001aze.2_RNA|CROCCL1_uc001azf.2_RNA					Homo sapiens mRNA for FLJ00313 protein.												0						TGCTGCAGGGCAGCAATCTCC	0.667000													4	30					0	0	0.000602214	0	0
DDX20	11218	broad.mit.edu	37	1	112303729	112303729	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:112303729T>G	uc001ebs.2	+	6	1301	c.944T>G	c.(943-945)TTT>TGT	p.F315C	DDX20_uc010owf.1_Missense_Mutation_p.F77C|DDX20_uc001ebt.2_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	315	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTTTAGTCTTTTCTAATTTG	0.353000													32	47					0	0	0.000409698	0	0
RXFP4	339403	broad.mit.edu	37	1	155912175	155912175	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:155912175G>A	uc010pgs.1	+	1	696	c.675G>A	c.(673-675)CTG>CTA	p.L225L		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	225	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCAGCTACCTGCTGCTGCTGG	0.662000													7	77					0	0	0.000442599	0	0
DSTYK	25778	broad.mit.edu	37	1	205132071	205132071	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:205132071G>A	uc001hbw.2	-	5	1685	c.1621C>T	c.(1621-1623)CTA>TTA	p.L541L	DSTYK_uc001hbx.2_Silent_p.L541L|DSTYK_uc001hby.1_Silent_p.L2L	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	541						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						TGCTCCCATAGCATCCTTGTA	0.418000													53	66					0	0	0.000781405	0	0
LEFTY1	10637	broad.mit.edu	37	1	226075314	226075314	+	Silent	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:226075314G>A	uc001hpo.2	-	3	592	c.522C>T	c.(520-522)GGC>GGT	p.G174G	LEFTY1_uc010pvj.1_Silent_p.L283L|LEFTY1_uc009xej.1_3'UTR	NM_020997	NP_066277	O75610	LFTY1_HUMAN	left-right determination, factor B	174					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					AGGCCTTCCAGCCGCTCTCGT	0.701000													20	29					0	0	0.000586117	0	0
AGT	183	broad.mit.edu	37	1	230841791	230841791	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr1:230841791C>T	uc001hty.3	-	3	1520	c.1012G>A	c.(1012-1014)GAG>AAG	p.E338K	AGT_uc009xfe.2_Missense_Mutation_p.E338K|AGT_uc009xff.2_Missense_Mutation_p.E310K	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	338					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	CAGGCGCTCTCAGTGAAGGGC	0.557000													51	86					0	0	0.000781405	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													8	83					0	0	0.000157383	0	0
ERLIN1	10613	broad.mit.edu	37	10	101911987	101911987	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr10:101911987A>G	uc001kqn.3	-	11	1299	c.948T>C	c.(946-948)TAT>TAC	p.Y316Y	ERLIN1_uc001kqm.3_Silent_p.Y81Y|ERLIN1_uc001kqo.3_Silent_p.Y316Y|ERLIN1_uc010qpm.1_Silent_p.Y232Y	NM_006459	NP_006450	O75477	ERLN1_HUMAN	ER lipid raft associated 1	314	Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding				0		Colorectal(252;0.234)		Epithelial(162;3.85e-10)|all cancers(201;3.25e-08)		TAATATCTGAATATTTCAAAG	0.443000													49	71					0	0	0.000680045	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7669667	7669667	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr11:7669667T>C	uc001mfj.3	+	18	2084	c.1696T>C	c.(1696-1698)TGG>CGG	p.W566R	PPFIBP2_uc010rbb.1_Missense_Mutation_p.W489R|PPFIBP2_uc001mfk.1_Intron|PPFIBP2_uc010rbc.1_Missense_Mutation_p.W500R|PPFIBP2_uc010rbe.1_Missense_Mutation_p.W454R|PPFIBP2_uc001mfl.3_Missense_Mutation_p.W423R|PPFIBP2_uc009yfj.1_Missense_Mutation_p.W210R	NM_003621	NP_003612	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2	566	SAM 1.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			ovary(2)|breast(2)	4				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TGTGTGTGCATGGCTGGAGGA	0.547000													38	61					0	0	0.00111076	0	0
KLRK1	22914	broad.mit.edu	37	12	10539567	10539567	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:10539567C>T	uc009zhj.2	-	3	247	c.83G>A	c.(82-84)AGT>AAT	p.S28N	uc001qya.1_Intron|KLRK1_uc001qyb.2_RNA|KLRK1_uc001qyc.2_Missense_Mutation_p.S28N|KLRK1_uc009zhk.2_Missense_Mutation_p.S28N|KLRK1_uc001qyd.2_Missense_Mutation_p.S28N	NM_007360	NP_031386	P26718	NKG2D_HUMAN	NKG2-D type II integral membrane protein	28	Cytoplasmic (Potential).				natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding				0						TGAAAAATCACTCTTCTTCAG	0.363000													16	28					0	0	0.000566183	0	0
STK38L	23012	broad.mit.edu	37	12	27468238	27468238	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:27468238C>A	uc001rhr.2	+	9	991	c.792C>A	c.(790-792)AAC>AAA	p.N264K	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.N171K|STK38L_uc010sjn.1_Missense_Mutation_p.N2K|STK38L_uc010sjo.1_5'Flank	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	264	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					AGAACATGAACTCAAAGAGGA	0.348000													22	66					1.85244e-09	1.46683e-08	0.00047179	1	0
KRT18	3875	broad.mit.edu	37	12	53344644	53344644	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:53344644A>G	uc001sbe.2	+	4	680	c.611A>G	c.(610-612)GAG>GGG	p.E204G	KRT18_uc009zmn.1_Missense_Mutation_p.E204G|KRT18_uc001sbf.1_Missense_Mutation_p.E31G|KRT18_uc001sbg.2_Missense_Mutation_p.E204G|KRT18_uc009zmo.2_Missense_Mutation_p.E204G|KRT8_uc009zml.1_5'Flank|KRT8_uc009zmm.1_5'Flank	NM_199187	NP_954657	P05783	K1C18_HUMAN	keratin 18	204	Coil 1B.|Rod.|Necessary for interaction with PNN.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			skin(1)	1						ACAGAGATCGAGGCTCTCAAG	0.577000													4	13					0	0	0.00024832	0	0
KRR1	11103	broad.mit.edu	37	12	75895546	75895546	+	Silent	SNP	T	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:75895546T>C	uc001sxt.2	-	9	1001	c.960A>G	c.(958-960)GCA>GCG	p.A320A	GLIPR1_uc001sxs.2_3'UTR|KRR1_uc009zsc.2_Silent_p.A263A	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	320	Lys-rich.				rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						GTGGAATAAATGCTTTGTTTC	0.259000													16	41					0	0	0.00121646	0	0
ACACB	32	broad.mit.edu	37	12	109692084	109692084	+	Silent	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:109692084C>T	uc001tob.2	+	44	6230	c.6111C>T	c.(6109-6111)CTC>CTT	p.L2037L	ACACB_uc001toc.2_Silent_p.L2037L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.L703L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2037	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	TTGAATTCCTCCCATCCAGAG	0.488000													79	123					0	0	0.000781405	0	0
CDAN1	146059	broad.mit.edu	37	15	43024004	43024004	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr15:43024004C>T	uc001zql.2	-	11	1670	c.1553G>A	c.(1552-1554)GGT>GAT	p.G518D	CDAN1_uc001zqj.2_5'Flank|CDAN1_uc001zqk.2_Translation_Start_Site	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	518						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCCCCCAGCACCACCAGGGCT	0.532000													25	53					0	0	0.000375601	0	0
TSC2	7249	broad.mit.edu	37	16	2138135	2138135	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:2138135G>A	uc002con.2	+	40	5261	c.5155G>A	c.(5155-5157)GCA>ACA	p.A1719T	TSC2_uc010bsd.2_Missense_Mutation_p.A1696T|TSC2_uc002coo.2_Missense_Mutation_p.A1652T|TSC2_uc010uvv.1_Missense_Mutation_p.A1616T|TSC2_uc010uvw.1_Missense_Mutation_p.A1604T|TSC2_uc002cop.2_Missense_Mutation_p.A1475T|TSC2_uc002coq.2_Missense_Mutation_p.A494T|TSC2_uc002cor.2_Missense_Mutation_p.A420T	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1719	Rap-GAP.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GGCCCTGCACGCAAATGTGAG	0.652000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				36	64					0	0	0.000814825	0	0
MGRN1	23295	broad.mit.edu	37	16	4731570	4731570	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:4731570C>A	uc002cwz.2	+	13	1287	c.1151C>A	c.(1150-1152)CCT>CAT	p.P384H	MGRN1_uc002cxa.2_Missense_Mutation_p.P384H|MGRN1_uc010btx.2_Missense_Mutation_p.P363H|MGRN1_uc010btw.2_Missense_Mutation_p.P363H|MGRN1_uc002cxb.2_Missense_Mutation_p.P423H|MGRN1_uc010uxo.1_Missense_Mutation_p.P362H|MGRN1_uc010uxp.1_Missense_Mutation_p.P362H|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	384					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						AGCGTCCCACCTGGCTACGAG	0.637000													23	47					3.5997e-14	3.03627e-13	0.000295444	1	0
PDXDC1	23042	broad.mit.edu	37	16	15130101	15130101	+	Nonsense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:15130101C>A	uc002dda.3	+	23	2560	c.2336C>A	c.(2335-2337)TCA>TAA	p.S779*	PDXDC1_uc010uzl.1_Nonsense_Mutation_p.S764*|PDXDC1_uc010uzm.1_Nonsense_Mutation_p.S688*|PDXDC1_uc002ddb.3_Nonsense_Mutation_p.S752*|PDXDC1_uc010uzn.1_Nonsense_Mutation_p.S751*|PDXDC1_uc002ddc.2_Intron	NM_015027	NP_055842	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain	779					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			skin(1)	1					Pyridoxal Phosphate(DB00114)	GATGACCACTCACAGGTAGAA	0.537000													43	100					1.00953e-15	8.70439e-15	0.000680045	1	0
ZFHX3	463	broad.mit.edu	37	16	72830449	72830449	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr16:72830449A>G	uc002fck.2	-	9	6805	c.6132T>C	c.(6130-6132)CCT>CCC	p.P2044P	ZFHX3_uc002fcl.2_Silent_p.P1130P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2044	Poly-Pro.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GAGGGGGTGGAGGGGGAGGTG	0.622000													5	116					0	0	0.00185496	0	0
STARD3	10948	broad.mit.edu	37	17	37817259	37817259	+	Nonsense_Mutation	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr17:37817259G>T	uc002hsd.2	+	13	1184	c.1060G>T	c.(1060-1062)GAG>TAG	p.E354*	STARD3_uc010weh.1_RNA|STARD3_uc002hse.2_Nonsense_Mutation_p.E336*|STARD3_uc010wei.1_Nonsense_Mutation_p.E354*|STARD3_uc002hsf.2_Nonsense_Mutation_p.E220*|STARD3_uc002hsg.2_Nonsense_Mutation_p.E187*	NM_006804	NP_006795	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain	354	START.|Cytoplasmic (Potential).				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCGGCGCATTGAGCGGCGCAG	0.602000													35	46					1.60099e-16	1.41178e-15	0.000953801	1	0
TMC8	147138	broad.mit.edu	37	17	76133427	76133427	+	Silent	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr17:76133427T>G	uc002jup.2	+	10	1621	c.1239T>G	c.(1237-1239)GTT>GTG	p.V413V	TMC8_uc002juq.2_Silent_p.V190V|TMC8_uc010wtr.1_Intron|TMC8_uc002jur.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	413	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCTACAACGTTTGTGACTATC	0.587000									Epidermodysplasia_Verruciformis_Familial_Clustering_of				64	107					0	0	0.000781405	0	0
RAB3D	9545	broad.mit.edu	37	19	11447891	11447891	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr19:11447891T>A	uc002mqy.2	-	2	423	c.185A>T	c.(184-186)AAG>ATG	p.K62M		NM_004283	NP_004274	O95716	RAB3D_HUMAN	RAB3D, member RAS oncogene family	62					exocytosis|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(2)	2						GTAGACGGTCTTGACCTTGAA	0.577000													106	223					0	0	0.000781405	0	0
CXCR1	3577	broad.mit.edu	37	2	219029397	219029397	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr2:219029397G>C	uc002vhc.2	-	2	657	c.538C>G	c.(538-540)CCA>GCA	p.P180A		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	180	Extracellular (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						GAATTGTTTGGATGGTAAGCC	0.512000													12	20					0	0	0.00136819	0	0
CXCR1	3577	broad.mit.edu	37	2	219029403	219029403	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr2:219029403A>T	uc002vhc.2	-	2	651	c.532T>A	c.(532-534)TAC>AAC	p.Y178N		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	178	Extracellular (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						TTTGGATGGTAAGCCTGGCGG	0.512000													11	20					0	0	0.00136819	0	0
PTPRA	5786	broad.mit.edu	37	20	3016489	3016489	+	Silent	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr20:3016489G>T	uc010zqd.1	+	21	2450	c.2133G>T	c.(2131-2133)GTG>GTT	p.V711V	PTPRA_uc002whj.2_Silent_p.V700V|PTPRA_uc002whk.2_Silent_p.V691V|PTPRA_uc002whl.2_Silent_p.V691V|PTPRA_uc002whm.2_Silent_p.V467V|PTPRA_uc002whn.2_Silent_p.V691V|PTPRA_uc002who.2_Silent_p.V363V	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	700	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						GGCCTGAAGTGGGCATCCCCA	0.587000													31	73					1.88708e-17	1.70276e-16	0.001512	1	0
CST9L	128821	broad.mit.edu	37	20	23548869	23548869	+	Silent	SNP	G	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr20:23548869G>T	uc002wtk.3	-	1	518	c.219C>A	c.(217-219)ATC>ATA	p.I73I		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	73						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					AGGAATTCAAGATGTGCCCCA	0.547000													17	41					3.41278e-10	2.75867e-09	0.000566183	1	0
PFKL	5211	broad.mit.edu	37	21	45741733	45741733	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr21:45741733G>A	uc002zel.2	+	13	1372	c.1313G>A	c.(1312-1314)GGC>GAC	p.G438D	PFKL_uc002zek.2_Missense_Mutation_p.G485D|PFKL_uc002zem.2_Missense_Mutation_p.G25D|PFKL_uc002zen.2_Missense_Mutation_p.G25D	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	438					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GTGCACGATGGCTTCGAAGGC	0.642000													5	130					0	0	0.00116845	0	0
POTEH	23784	broad.mit.edu	37	22	16287673	16287673	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr22:16287673C>G	uc010gqp.2	-	1	265	c.213G>C	c.(211-213)TGG>TGC	p.W71C	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	71										skin(1)	1						TCCCCCTGCACCAGGGGAAGC	0.582000													4	185					0	0	8.12818e-05	0	0
CTDSPL	10217	broad.mit.edu	37	3	38009318	38009318	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr3:38009318C>G	uc003chg.2	+	5	393	c.371C>G	c.(370-372)CCT>CGT	p.P124R	CTDSPL_uc003chh.2_Missense_Mutation_p.P113R|CTDSPL_uc003chi.2_RNA	NM_001008392	NP_001008393	O15194	CTDSL_HUMAN	small CTD phosphatase 3 isoform 1	124	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity				0		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		TTTCTCTAGCCTATTAGTAAT	0.308000											OREG0015472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	30					0	0	0.000978159	0	0
FYCO1	79443	broad.mit.edu	37	3	46008824	46008824	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr3:46008824C>T	uc003cpb.3	-	8	2208	c.2002G>A	c.(2002-2004)GCC>ACC	p.A668T	FYCO1_uc011bal.1_Missense_Mutation_p.A668T	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	668	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CGGATGCTGGCCTGCTCGGCC	0.632000													52	70					0	0	0.000781405	0	0
FNIP2	57600	broad.mit.edu	37	4	159825696	159825696	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr4:159825696A>G	uc003iqe.3	+	17	3528	c.3345A>G	c.(3343-3345)TAA>TAG	p.*1115*	C4orf45_uc003iqf.1_Intron|C4orf45_uc010iqt.1_Intron	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	1115					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TACTCTTATAAGCTAAAGCTC	0.388000													38	65					0	0	0.00128727	0	0
ZCCHC10	54819	broad.mit.edu	37	5	132334373	132334373	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:132334373A>G	uc003kyh.2	-	5	492	c.481T>C	c.(481-483)TCT>CCT	p.S161P	ZCCHC10_uc003kyg.2_Missense_Mutation_p.S139P|ZCCHC10_uc011cxl.1_Missense_Mutation_p.S125P	NM_017665	NP_060135	Q8TBK6	ZCH10_HUMAN	zinc finger, CCHC domain containing 10	161	Ser-rich.						nucleic acid binding|zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTGAATCAgaggaggaggaa	0.333000													19	55					0	0	0.000958276	0	0
RBM27	54439	broad.mit.edu	37	5	145610424	145610424	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:145610424C>A	uc003lnz.3	+	6	960	c.794C>A	c.(793-795)TCT>TAT	p.S265Y	RBM27_uc003lny.2_Missense_Mutation_p.S265Y	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	265					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATCATAGCTCTTCCAATTCT	0.428000													31	45					5.60225e-13	4.62484e-12	0.00178596	1	0
ARSI	340075	broad.mit.edu	37	5	149677576	149677576	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:149677576G>A	uc003lrv.2	-	2	1500	c.911C>T	c.(910-912)TCG>TTG	p.S304L		NM_001012301	NP_001012301	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I precursor	304						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGCCCCCCGAGAAAGTCTG	0.587000													26	37					0	0	0.000720815	0	0
F12	2161	broad.mit.edu	37	5	176830985	176830985	+	Silent	SNP	G	A	A	rs148322446		TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr5:176830985G>A	uc003mgo.3	-	10	1174	c.1125C>T	c.(1123-1125)GGC>GGT	p.G375G	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	375	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCACCAGCCCGCCAACGACGC	0.706000									Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	11					0	0	0.000308642	0	0
NDUFAF4	29078	broad.mit.edu	37	6	97344647	97344647	+	Silent	SNP	A	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr6:97344647A>G	uc003pow.2	-	2	303	c.213T>C	c.(211-213)GAT>GAC	p.D71D	NDUFAF4_uc003pov.2_RNA	NM_014165	NP_054884	Q9P032	NDUF4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	71					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			ovary(1)	1						GATCTTTGGAATCAACATACA	0.358000													27	69					0	0	0.001512	0	0
CALU	813	broad.mit.edu	37	7	128407599	128407599	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:128407599C>A	uc003vns.2	+	6	885	c.733C>A	c.(733-735)CGT>AGT	p.R245S	CALU_uc003vnq.2_Missense_Mutation_p.R245S|CALU_uc003vnr.2_Missense_Mutation_p.R245S	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	245	EF-hand 5.|5 (Potential).				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						GGATAAGAACCGTGATGGGAA	0.488000													4	117					0.000602214	0.00458155	0.000602214	1	0
CHCHD3	54927	broad.mit.edu	37	7	132709362	132709362	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:132709362T>A	uc003vre.2	-	3	331	c.195A>T	c.(193-195)AGA>AGT	p.R65S	CHCHD3_uc010lmi.2_RNA|CHCHD3_uc003vrf.2_Missense_Mutation_p.R65S|CHCHD3_uc010lmj.2_5'UTR|CHCHD3_uc011kpn.1_Missense_Mutation_p.R65S	NM_017812	NP_060282	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain	65					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold				0						CCTCAGCTACTCTTCTTTTCA	0.383000													18	149					0	0	0.00074312	0	0
KRBA1	84626	broad.mit.edu	37	7	149416749	149416749	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr7:149416749C>T	uc003wfz.2	+	2	419	c.20C>T	c.(19-21)ACG>ATG	p.T7M	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	7										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AACTACGAGACGCTGGTCTCT	0.657000													9	26					0	0	0.000442599	0	0
TG	7038	broad.mit.edu	37	8	133931710	133931710	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr8:133931710T>G	uc003ytw.2	+	21	4509	c.4468T>G	c.(4468-4470)TGT>GGT	p.C1490G	TG_uc010mdw.2_Missense_Mutation_p.C249G|TG_uc011ljb.1_5'UTR|TG_uc003ytx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1490	Type II.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GAGCTTGGCCTGTGTCCCATG	0.478000													35	56					0	0	0.000953801	0	0
GNPTAB	79158	broad.mit.edu	37	12	102159058	102159058	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr12:102159058delA	uc001tit.2	-	13	1816	c.1637delT	c.(1636-1638)GTGfs	p.V546fs		NM_024312	NP_077288	Q3T906	GNPTA_HUMAN	N-acetylglucosamine-1-phosphate transferase	546					cell differentiation	Golgi membrane|integral to membrane|nucleus	metal ion binding|transcription factor binding|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity			ovary(1)|skin(1)	2						GAGAAGGATCACTTTATACAA	0.358													33	68	---	---	---	---					
LACTB	114294	broad.mit.edu	37	15	63414861	63414861	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr15:63414861delG	uc002alw.2	+	2	423	c.384delG	c.(382-384)GTGfs	p.V128fs	LACTB_uc002alv.2_Frame_Shift_Del_p.V128fs	NM_032857	NP_116246	P83111	LACTB_HUMAN	lactamase, beta isoform a	128						mitochondrion	hydrolase activity				0						CGGGCATAGTGGTTGGAGTTT	0.488													35	73	---	---	---	---					
KIAA1632	57724	broad.mit.edu	37	18	43464597	43464598	+	Frame_Shift_Ins	INS	-	AA	AA			TCGA-G7-6792-01A-21D-1961-08	TCGA-G7-6792-10A-01D-1962-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcb71dd8-5625-4d0c-9148-b70199b7f6f3	381c414c-def1-4d55-95b5-9071eaf29fa6	g.chr18:43464597_43464598insAA	uc002lbm.2	-	30	5388_5389	c.5288_5289insTT	c.(5287-5289)TTCfs	p.F1763fs	KIAA1632_uc010xcq.1_Frame_Shift_Ins_p.F317fs|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Frame_Shift_Ins_p.F638fs	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1763					autophagy						0						TTAGCAGCATGAAAATCATATC	0.421													39	83	---	---	---	---					
